Structure and expression of conserved Wnt pathway components in the demosponge Amphimedon queenslandica

Wnt/β-Catenin Signaling in Development and Disease

Clevers, H. (2006) · Cell · doi:10.1016/j.cell.2006.10.018 · Cited by 5,568 · see citing works

The Wnt Signaling Pathway in Development and Disease

Logan, C. Y., & Nusse, R. (2004) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.20.010403.113126 · Cited by 5,325 · see citing works

Functional interaction of β-catenin with the transcription factor LEF-1

Behrens, J., von Kries, J. P., Kühl, M., Bruhn, L., Wedlich, D., Grosschedl, R., & Birchmeier, W. (1996) · Nature · doi:10.1038/382638a0 · Cited by 2,912 · see citing works

Control of β-Catenin Phosphorylation/Degradation by a Dual-Kinase Mechanism

Liu, C., Li, Y., Semënov, M. V., Han, C., Baeg, G., Tan, Y., Zhang, Z., Lin, X., & He, X. (2002) · Cell · doi:10.1016/s0092-8674(02)00685-2 · Cited by 2,066 · see citing works

PHYLIP (Phylogeny Inference Package)

Cummings, M. P. (2004) · Dictionary of Bioinformatics and Computational Biology · doi:10.1002/0471650129.dob0534 · Cited by 1,967 · see citing works

Sea Anemone Genome Reveals Ancestral Eumetazoan Gene Repertoire and Genomic Organization

Putnam, N. H., Srivastava, M., Hellsten, U., Dirks, B., Chapman, J., Salamov, A., Terry, A., Shapiro, H., Lindquist, E., Kapitonov, V. V., et al. (2007) · Science · doi:10.1126/science.1139158 · Cited by 1,555 · see citing works

A new member of the frizzled family from Drosophila functions as a Wingless receptor

Bhanot, P., van den Brink, M. R. M., Samos, C. H., Hsieh, J.-C., Wang, Y., Macke, J. P., Andrew, D. J., Nathans, J., & Nusse, R. (1996) · Nature · doi:10.1038/382225a0 · Cited by 1,504 · see citing works

PHYML Online--a web server for fast maximum likelihood-based phylogenetic inference

Guindon, S., Lethiec, F., Duroux, P., & Gascuel, O. (2005) · Nucleic Acids Research · doi:10.1093/nar/gki352 · Cited by 1,498 · see citing works

The genome of the social amoeba Dictyostelium discoideum

Eichinger, L., Pachebat, J. A., Glöckner, G., Rajandream, M.-A., Sucgang, R., Berriman, M., Song, J., Olsen, R., Szafranski, K., Xu, Q., et al. (2005) · Nature · doi:10.1038/nature03481 · Cited by 1,351 · see citing works

LDL-receptor-related proteins in Wnt signal transduction

Tamai, K., Semënov, M. V., Kato, Y., Spokony, R. F., Liu, C., Katsuyama, Y., Hess, F. J., Saint‐Jeannet, J., & He, X. (2000) · Nature · doi:10.1038/35035117 · Cited by 1,334 · see citing works

Functional Interaction of an Axin Homolog, Conductin, with β-Catenin, APC, and GSK3β

Behrens, J., Jerchow, B., Würtele, M., Grimm, J., Asbrand, C., Wirtz, R. M., Kühl, M., Wedlich, D., & Birchmeier, W. (1998) · Science · doi:10.1126/science.280.5363.596 · Cited by 1,255 · see citing works

Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK‐3β and β‐catenin and promotes GSK‐3β‐dependent phosphorylation of β‐catenin

Ikeda, S., Kishida, S., Yamamoto, H., Murai, H., Koyama, S., & Kikuchi, A. (1998) · The EMBO Journal · doi:10.1093/emboj/17.5.1371 · Cited by 1,248 · see citing works

The axis-inducing activity, stability, and subcellular distribution of beta-catenin is regulated in Xenopus embryos by glycogen synthase kinase 3.Preprint

Yost, C., Torres, M., Miller, J., Huang, E., Kimelman, D., & Moon, R. T. (1996) · Genes & Development · doi:10.1101/gad.10.12.1443 · Cited by 1,167 · see citing works

The genome of the choanoflagellate Monosiga brevicollis and the origin of metazoans

King, N., Westbrook, M. J., Young, S. L., Kuo, A., Abedin, M., Chapman, J., Fairclough, S., Hellsten, U., Isogai, Y., Letunic, I., et al. (2008) · Nature · doi:10.1038/nature06617 · Cited by 1,139 · see citing works

The Genome of the Sea Urchin <i>Strongylocentrotus purpuratus</i>

Sodergren, E., Weinstock, G. M., Davidson, E. H., Cameron, R. A., Gibbs, R. A., Angerer, R. C., Angerer, L. M., Arnone, M. I., Burgess, D. R., Burke, R. D., et al. (2006) · Science · doi:10.1126/science.1133609 · Cited by 1,132 · see citing works

The Amphimedon queenslandica genome and the evolution of animal complexity

Srivastava, M., Simakov, O., Chapman, J., Fahey, B., Gauthier, M. E. A., Mitros, T., Richards, G. S., Conaco, C., Dacre, M., Hellsten, U., et al. (2010) · Nature · doi:10.1038/nature09201 · Cited by 1,049 · see citing works

A dual-kinase mechanism for Wnt co-receptor phosphorylation and activation

Zeng, X., Tamai, K., Doble, B. W., Li, S., Huang, H., Habas, R., Okamura, H., Woodgett, J. R., & He, X. (2005) · Nature · doi:10.1038/nature04185 · Cited by 849 · see citing works

Low-Density Lipoprotein Receptor-Related Protein-5 Binds to Axin and Regulates the Canonical Wnt Signaling Pathway

Mao, J., Wang, J., Liu, B., Pan, W., Farr, G. H., Flynn, C., Yuan, H., Takada, S., Kimelman, D., Li, L., et al. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00224-6 · Cited by 839 · see citing works

Downregulation of β-catenin by human Axin and its association with the APC tumor suppressor, β-catenin and GSK3β

Hart, M. J., Santos, R. D. L., Albert, I., Rubinfeld, B., & Polakis, P. G. (1998) · Current Biology · doi:10.1016/s0960-9822(98)70226-x · Cited by 836 · see citing works

Assessing the root of bilaterian animals with scalable phylogenomic methods

Hejnol, A., Obst, M., Stamatakis, A., Ott, M., Rouse, G. W., Edgecombe, G. D., Martinez, P., Baguñà, J., Bailly, X., Jondelius, U., et al. (2009) · Proceedings of the Royal Society B: Biological Sciences · doi:10.1098/rspb.2009.0896 · Cited by 747 · see citing works

Drosophila Tcf and Groucho interact to repress Wingless signalling activity

Cavallo, R. A., Cox, R. T., Moline, M. M., Roose, J., Polevoy, G. A., Clevers, H., Peifer, M., & Bejsovec, A. (1998) · Nature · doi:10.1038/26982 · Cited by 730 · see citing works

Serine Phosphorylation-regulated Ubiquitination and Degradation of β-Catenin

Orford, K. W., Crockett, C., Jensen, J. P., Weissman, A. M., & Byers, S. W. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.40.24735 · Cited by 714 · see citing works

Phylogenomics Revives Traditional Views on Deep Animal Relationships

Philippe, H., Derelle, R., Lopez, P., Pick, K., Borchiellini, C., Boury-Esnault, N., Vacelet, J., Renard, E., Houliston, E., Quéinnec, E., et al. (2009) · Current Biology · doi:10.1016/j.cub.2009.02.052 · Cited by 695 · see citing works

The Xenopus Wnt effector XTcf-3 interacts with Groucho-related transcriptional repressors

Roose, J. P., Molenaar, M., Peterson, J., Hurenkamp, J., Brantjes, H., Moerer, P., van de Wetering, M., Destrée, O., & Clevers, H. C. (1998) · Nature · doi:10.1038/26989 · Cited by 674 · see citing works

Differential recruitment of Dishevelled provides signaling specificity in the planar cell polarity and Wingless signaling pathwaysPreprint

Axelrod, J. D., Miller, J. R., Shulman, J. M., Moon, R. T., & Perrimon, N. (1998) · Genes & Development · doi:10.1101/gad.12.16.2610 · Cited by 659 · see citing works

LEF-1, a gene encoding a lymphoid-specific protein with an HMG domain, regulates T-cell receptor alpha enhancer function [corrected]Preprint

Travis, A., Amsterdam, A., Bélanger, C., & Grosschedl, R. (1991) · Genes & Development · doi:10.1101/gad.5.5.880 · Cited by 614 · see citing works

β-catenin directly displaces Groucho/TLE repressors from Tcf/Lef in Wnt-mediated transcription activation

Daniels, D., & Weis, W. (2005) · Nature Structural &Molecular Biology · doi:10.1038/nsmb912 · Cited by 614 · see citing works

Unexpected complexity of the Wnt gene family in a sea anemone

Kusserow, A., Pang, K., Sturm, C., Hrouda, M., Lentfer, J., Schmidt, H. A., Technau, U., von Haeseler, A., Hobmayer, B., Martindale, M. Q., et al. (2005) · Nature · doi:10.1038/nature03158 · Cited by 599 · see citing works

Casein kinase 1 γ couples Wnt receptor activation to cytoplasmic signal transduction

Davidson, G. R., Wu, W., Shen, J., Bilić, J., Fenger, U., Stannek, P., Glinka, A., & Niehrs, C. (2005) · Nature · doi:10.1038/nature04170 · Cited by 581 · see citing works

A family of secreted proteins contains homology to the cysteine-rich ligand-binding domain of frizzled receptors

Rattner, A., Hsieh, J.-C., Smallwood, P. M., Gilbert, D. J., Copeland, N. G., Jenkins, N. A., & Nathans, J. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.7.2859 · Cited by 574 · see citing works

A Mechanism for Wnt Coreceptor Activation

Tamai, K., Zeng, X., Liu, C., Zhang, X., Harada, Y., Chang, Z., & He, X. (2004) · Molecular Cell · doi:10.1016/s1097-2765(03)00484-2 · Cited by 556 · see citing works

Direct Binding of the PDZ Domain of Dishevelled to a Conserved Internal Sequence in the C-Terminal Region of Frizzled

Wong, H.-C., Bourdelas, A., Krauss, A., Lee, H., Shao, Y., Wu, D., Mlodzik, M., Shi, D., & Zheng, J. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00427-1 · Cited by 531 · see citing works

Maternal Wnt11 Activates the Canonical Wnt Signaling Pathway Required for Axis Formation in Xenopus Embryos

Tao, Q., Yokota, C., Puck, H., Kofron, M., Birsoy, B., Yan, D., Asashima, M., Wylie, C. C., Lin, X., & Heasman, J. (2005) · Cell · doi:10.1016/j.cell.2005.01.013 · Cited by 510 · see citing works

Functional Redundancy of GSK-3α and GSK-3β in Wnt/β-Catenin Signaling Shown by Using an Allelic Series of Embryonic Stem Cell Lines

Doble, B. W., Patel, S., Wood, G. A., Kockeritz, L. K., & Woodgett, J. R. (2007) · Developmental Cell · doi:10.1016/j.devcel.2007.04.001 · Cited by 449 · see citing works

Groucho/TLE family proteins and transcriptional repression.

Chen, G.-Q., & Courey, A. (2000) · Gene · doi:10.1016/s0378-1119(00)00161-x · Cited by 437 · see citing works

Wnt/β-catenin signaling

Akiyama, T. (2000) · Cytokine & Growth Factor Reviews · doi:10.1016/s1359-6101(00)00011-3 · Cited by 426 · see citing works

Crystal Structure of a β-Catenin/Tcf Complex

Graham, T. A., Weaver, C. I., Mao, F., Kimelman, D., & Xu, W. (2000) · Cell · doi:10.1016/s0092-8674(00)00192-6 · Cited by 406 · see citing works

DIX Domains of Dvl and Axin Are Necessary for Protein Interactions and Their Ability To Regulate β-Catenin Stability

Kishida, S., Yamamoto, H., Hino, S.-I., Ikeda, S., Kishida, M., & Kikuchi, A. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.6.4414 · Cited by 400 · see citing works

Formation of protein kinase recognition sites by covalent modification of the substrate. Molecular mechanism for the synergistic action of casein kinase II and glycogen synthase kinase 3.

Fiol, C. J., Mahrenholz, A. M., Wang, Y., Roeske, R. W., & Roach, P. J. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)47901-x · Cited by 367 · see citing works

A Large Family of Putative Transmembrane Receptors Homologous to the Product of the Drosophila Tissue Polarity Gene frizzled

Wang, Y., Macke, J. P., Abella, B. S., Andreasson, K. I., Worley, P. F., Gilbert, D. J., Copeland, N. G., Jenkins, N. A., & Nathans, J. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.8.4468 · Cited by 364 · see citing works

Wnt signals across the plasma membrane to activate the β-catenin pathway by forming oligomers containing its receptors, Frizzled and LRP

Cong, F., Schweizer, L., & VARMUS, H. E. (2004) · Development · doi:10.1242/dev.01318 · Cited by 364 · see citing works

All Tcf HMG box transcription factors interact with Groucho-related co-repressors

Brantjes, H. (2001) · Nucleic Acids Research · doi:10.1093/nar/29.7.1410 · Cited by 361 · see citing works

Early evolution of animal cell signaling and adhesion genes

Nichols, S., Dirks, W., Pearse, J. S., & King, N. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604065103 · Cited by 327 · see citing works

An ancient role for nuclear β-catenin in the evolution of axial polarity and germ layer segregation

Wikramanayake, A. H., Hong, M., Lee, P. N., Pang, K., Byrum, C. A., Bince, J. M., Xu, R., & Martindale, M. Q. (2003) · Nature · doi:10.1038/nature02113 · Cited by 324 · see citing works

Human homologs of a Drosophila Enhancer of Split gene product define a novel family of nuclear proteins

Stifani, S., Blaumueller, C. M., Redhead, N. J., et al. (1992) · Nature Genetics · doi:10.1038/ng1092-119 · Cited by 308 · see citing works

Mechanism of Phosphorylation-Dependent Binding of APC to β-Catenin and Its Role in β-Catenin Degradation

Ha, N., Tonozuka, T., Stamos, J. L., Choi, H., & Weis, W. I. (2004) · Molecular Cell · doi:10.1016/j.molcel.2004.08.010 · Cited by 304 · see citing works

The C‐terminal cytoplasmic Lys‐Thr‐X‐X‐X‐Trp motif in frizzled receptors mediates Wnt/β‐catenin signalling

Umbhauer, M., Djiane, A., Goisset, C., Penzo‐Méndez, A., Riou, J., Boucaut, J., & Shi, D. (2000) · The EMBO Journal · doi:10.1093/emboj/19.18.4944 · Cited by 303 · see citing works

Axin, an inhibitor of the Wnt signalling pathway, interacts with β‐catenin, GSK‐3β and APC and reduces the β‐catenin level

Nakamura, T., Hamada, F., Ishidate, T., Anai, K., Kawahara, K., Toyoshima, K., & Akiyama, T. (1998) · Genes to Cells · doi:10.1046/j.1365-2443.1998.00198.x · Cited by 295 · see citing works

Wg/Wnt Signal Can Be Transmitted through Arrow/LRP5,6 and Axin Independently of Zw3/Gsk3β Activity

Tolwinski, N. S., Wehrli, M., Rives, A., Erdeniz, N., DiNardo, S., & Wieschaus, E. (2003) · Developmental Cell · doi:10.1016/s1534-5807(03)00063-7 · Cited by 286 · see citing works

Genesis and Expansion of Metazoan Transcription Factor Gene Classes

Larroux, C., Luke, G. N., Koopman, P. A., Rokhsar, D. S., Shimeld, S. M., & Degnan, B. M. (2008) · Molecular Biology and Evolution · doi:10.1093/molbev/msn047 · Cited by 275 · see citing works

Domains of Axin Involved in Protein–Protein Interactions, Wnt Pathway Inhibition, and Intracellular Localization

Fagotto, F., Jho, E., Zeng, L., Kurth, T., Joos, T., Kaufmann, C. M., & Costantini, F. D. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.145.4.741 · Cited by 269 · see citing works

Wnt and TGF-β Expression in the Sponge Amphimedon queenslandica and the Origin of Metazoan Embryonic Patterning

Adamska, M., Degnan, S. M., Green, K. M., Adamski, M., Craigie, A., Larroux, C., & Degnan, B. M. (2007) · PLoS ONE · doi:10.1371/journal.pone.0001031 · Cited by 257 · see citing works

The cysteine-rich frizzled domain of Frzb-1 is required and sufficient for modulation of Wnt signaling

Lin, K., Wang, S., Julius, M. A., Kitajewski, J., Moos, M. C., & Luyten, F. P. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.21.11196 · Cited by 251 · see citing works

Frizzled signalling and cell polarisation inDrosophilaand vertebrates

Strutt, D. I. (2003) · Development · doi:10.1242/dev.00695 · Cited by 243 · see citing works

Crystal structure of a β-catenin/Axin complex suggests a mechanism for the β-catenin destruction complex

Xing, Y., Clements, W. K., Kimelman, D., & Xu, W. (2003) · Genes &amp; Development · doi:10.1101/gad.1142603 · Cited by 237 · cited 3× · see citing works

Cytological Basis of Photoresponsive Behavior in a Sponge Larva

Leys, S. P., & Degnan, B. M. (2001) · The Biological Bulletin · doi:10.2307/1543611 · Cited by 212 · see citing works

Structural basis of the Axin–adenomatous polyposis coli interaction

Spink, K. E., Polakis, P. G., & Weis, W. I. (2000) · The EMBO Journal · doi:10.1093/emboj/19.10.2270 · Cited by 211 · see citing works

The evolution of metazoan axial properties

Martindale, M. Q. (2005) · Nature Reviews Genetics · doi:10.1038/nrg1725 · Cited by 204 · see citing works

Nuclear-cytoplasmic shuttling of Axin regulates subcellular localization of β-catenin

Cong, F., & VARMUS, H. E. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0307344101 · Cited by 189 · see citing works

A maternally localised Wnt ligand required for axial patterning in the cnidarian Clytia hemisphaerica

Momose, T., Derelle, R., & Houliston, E. (2008) · Development · doi:10.1242/dev.021543 · Cited by 170 · see citing works

Two Oppositely Localised Frizzled RNAs as Axis Determinants in a Cnidarian Embryo

Momose, T., & Houliston, E. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050070 · Cited by 163 · see citing works

Planar cell polarity signaling in vertebrates

Jones, C., & Chen, P. (2007) · BioEssays · doi:10.1002/bies.20526 · Cited by 161 · see citing works

Crystal Structure of a β-Catenin/APC Complex Reveals a Critical Role for APC Phosphorylation in APC Function

Xing, Y., Clements, W. K., Trong, I. L., Hinds, T. R., Stenkamp, R. E., Kimelman, D., & Xu, W. (2004) · Molecular Cell · doi:10.1016/j.molcel.2004.08.001 · Cited by 156 · see citing works

Asymmetric Localization of Frizzled and the Determination of Notch-Dependent Cell Fate in the Drosophila Eye

Strutt, D. I., Johnson, R. I., Cooper, K., & Bray, S. J. (2002) · Current Biology · doi:10.1016/s0960-9822(02)00841-2 · Cited by 148 · see citing works

Adherens junctions and β-catenin-mediated cell signalling in a non-metazoan organism

Grimson, M. J., Coates, J. C., Reynolds, J. P., Shipman, M., Blanton, R. L., & Harwood, A. J. (2000) · Nature · doi:10.1038/35047099 · Cited by 140 · see citing works

The ‘Marx’ of Groucho on development and disease

Buscarlet, M., & Stifani, S. (2007) · Trends in Cell Biology · doi:10.1016/j.tcb.2007.07.002 · Cited by 138 · see citing works

The Axin-like protein PRY-1 is a negative regulator of a canonical Wnt pathway in C. elegansPreprint

Korswagen, H. C., Coudreuse, D., Betist, M. C., van de Water, S., Zivkovic, D., & Jc, C. (2002) · Genes & Development · doi:10.1101/gad.981802 · Cited by 135 · see citing works

Asymmetric developmental potential along the animal–vegetal axis in the anthozoan cnidarian, Nematostella vectensis, is mediated by Dishevelled

Lee, P. N., Kumburegama, S., Marlow, H. Q., Martindale, M. Q., & Wikramanayake, A. H. (2007) · Developmental Biology · doi:10.1016/j.ydbio.2007.05.040 · Cited by 135 · see citing works

The Wnt/β-Catenin Signaling Pathway as a Target in Drug Discovery

Takahashi‐Yanaga, F., & Sasaguri, T. (2007) · Journal of Pharmacological Sciences · doi:10.1254/jphs.cr0070024 · Cited by 133 · see citing works

Molecular mechanisms of β‐catenin recognition by adenomatous polyposis coli revealed by the structure of an APC–β‐catenin complex

Spink, K. E., Fridman, S. G., & Weis, W. I. (2001) · The EMBO Journal · doi:10.1093/emboj/20.22.6203 · Cited by 133 · see citing works

Wnt/Wingless signaling through β-catenin requires the function of both LRP/Arrow and frizzled classes of receptors

Schweizer, L., & VARMUS, H. E. (2003) · BMC Cell Biology · doi:10.1186/1471-2121-4-4 · Cited by 125 · see citing works

Wnt signaling in ovarian tumorigenesis

Gatcliffe, T. A., Monk, B. J., Planutis, K., & Holcombe, R. F. (2007) · International Journal of Gynecological Cancer · doi:10.1111/j.1525-1438.2007.01127.x · Cited by 124 · see citing works

The Dawn of Developmental Signaling in the MetazoaPreprint

Richards, G. S., & Degnan, B. M. (2009) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2009.74.028 · Cited by 117 · see citing works

Adenomatous polyposis coli (APC) plays multiple roles in the intestinal and colorectal epithelia

Senda, T., Iizuka‐Kogo, A., Onouchi, T., & Shimomura, A. (2007) · Medical Molecular Morphology · doi:10.1007/s00795-006-0352-5 · Cited by 103 · see citing works

Wnt Signal Amplification via Activity, Cooperativity, and Regulation of Multiple Intracellular PPPSP Motifs in the Wnt Co-receptor LRP6

MacDonald, B. T., Yokota, C., Tamai, K., Zeng, X., & He, X. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m800327200 · Cited by 102 · see citing works

A GSK3β Phosphorylation Site in Axin Modulates Interaction with β-Catenin and Tcf-Mediated Gene Expression

Jho, E., Lomvardas, S., & Costantini, F. D. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.1760 · Cited by 95 · see citing works

Wnt11/β-catenin signaling in both oocytes and early embryos acts through LRP6-mediated regulation of axin

Kofron, M. J., Birsoy, B., Houston, D. W., Tao, Q., Wylie, C. C., & Heasman, J. (2007) · Development · doi:10.1242/dev.02739 · Cited by 95 · see citing works

Identification of a brain-specific APC homologue, APCL, and its interaction with beta-catenin.

Nakagawa, H., Murata, Y., Koyama, K., Fujiyama, A., Miyoshi, Y., Monden, M., Akiyama, T., & Nakamura, Y. (1998) · PubMed · Cited by 94 · see citing works

DrosophilaApc1 and Apc2 regulate Wingless transduction throughout development

Ahmed, Y. F., Nouri, A., & Wieschaus, E. F. (2002) · Development · doi:10.1242/dev.129.7.1751 · Cited by 93 · see citing works

WNT/β-Catenin Signalling and Epithelial Patterning in the Homoscleromorph Sponge Oscarella

Lapébie, P., Gazave, E., Ereskovsky, A. V., Derelle, R., Bézac, C., Renard, E., Houliston, E., & Borchiellini, C. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005823 · Cited by 91 · see citing works

The Dictyostelium repertoire of seven transmembrane domain receptors

Prabhu, Y., & Eichinger, L. (2006) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2006.04.003 · Cited by 87 · see citing works

The Divergent <i>Caenorhabditis elegans</i> β-Catenin Proteins BAR-1, WRM-1 and HMP-2 Make Distinct Protein Interactions but Retain Functional Redundancy <i>in Vivo</i>

Natarajan, L., Witwer, N. E., & Eisenmann, D. M. (2001) · Genetics · doi:10.1093/genetics/159.1.159 · Cited by 75 · see citing works

Glycogen synthase kinase-3 (GSK-3) is regulated during Dictyostelium development via the serpentine receptor cAR3

Plyte, S. E., O’Donovan, E., Woodgett, J. R., et al. (1999) · Development · doi:10.1242/dev.126.2.325 · Cited by 68 · see citing works

The canonical Wnt pathway in embryonic axis polarity

Croce, J. C., & McClay, D. R. (2006) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2006.04.004 · Cited by 67 · see citing works

Direct interaction of Frizzled‐1, ‐2, ‐4, and ‐7 with PDZ domains of PSD‐95

Hering, H., & Sheng, M. (2002) · FEBS Letters · doi:10.1016/s0014-5793(02)02831-4 · Cited by 65 · see citing works

Isolation and characterization of Wnt pathway‐related genes from Porifera

Adell, T., Thakur, A. N., & Müller, W. E. G. (2007) · Cell Biology International · doi:10.1016/j.cellbi.2007.03.003 · Cited by 60 · see citing works

Receptor-Dependent and Tyrosine Phosphatase-Mediated Inhibition of GSK3 Regulates Cell Fate Choice

Kim, L., Harwood, A. J., & Kimmel, A. R. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00269-1 · Cited by 56 · see citing works

Unexpectedly robust assembly of the Axin destruction complex regulates Wnt/Wg signaling in Drosophila as revealed by analysis in vivo

Peterson-Nedry, W., Erdeniz, N., Kremer, S., Yu, J., Baig-Lewis, S., & Wehrli, M. (2008) · Developmental Biology · doi:10.1016/j.ydbio.2008.05.521 · Cited by 54 · see citing works

Sponge Development and Antiquity of Animal Pattern Formation

Degnan, B. M. (2005) · Integrative and Comparative Biology · doi:10.1093/icb/45.2.335 · Cited by 54 · see citing works

Nuclear β‐catenin promotes non‐neural ectoderm and posterior cell fates in amphioxus embryos

Holland, L. Z., Panfilio, K. A., Chastain, R. A., Schubert, M., & Holland, N. D. (2005) · Developmental Dynamics · doi:10.1002/dvdy.20473 · Cited by 47 · see citing works

Dimerization Choices Control the Ability of Axin and Dishevelled to Activate c-Jun N-terminal Kinase/Stress-activated Protein Kinase

Zhang, Y., Neo, S. Y., Lin, S., & Han, J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m002491200 · Cited by 47 · see citing works

The DIX Domain Protein Coiled-coil-DIX1 Inhibits c-Jun N-terminal Kinase Activation by Axin and Dishevelled through Distinct Mechanisms

Wong, C. K., Luo, W., Deng, Y., Zou, H., Ye, Z., & Lin, S. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m404598200 · Cited by 44 · see citing works

Analysis of dishevelled localization and function in the early sea urchin embryo

Leonard, J. D., & Ettensohn, C. A. (2007) · Developmental Biology · doi:10.1016/j.ydbio.2007.02.041 · Cited by 39 · see citing works

Loss of the β-catenin homologue aardvark causes ectopic stalk formation in Dictyostelium

Coates, J. C., Grimson, M., Williams, R. S. B., Bergman, W., Blanton, R., & Harwood, A. (2002) · Mechanisms of Development · doi:10.1016/s0925-4773(02)00152-1 · Cited by 36 · see citing works

Identification and characterization of E‐APC, a novel Drosophila homologue of the tumour suppressor APC

Hamada, F., Murata, Y., Nishida, A., Fujita, F., Tomoyasu, Y., Nakamura, M., Toyoshima, K., Tabata, T., Ueno, N., & Akiyama, T. (1999) · Genes to Cells · doi:10.1046/j.1365-2443.1999.00272.x · Cited by 30 · see citing works

Two functionally distinct Axin-like proteins regulate canonical Wnt signaling in C. elegans

Oosterveen, T., Coudreuse, D. Y. M., Yang, P., Fraser, E., Bergsma, J., Dale, T. C., & Korswagen, H. C. (2007) · Developmental Biology · doi:10.1016/j.ydbio.2007.05.043 · Cited by 28 · see citing works

Wnt Signaling in Stem Cells and Lung Cancer

He, B., & Jablons, D. M. (2007) · Springer eBooks · doi:10.1007/2789_2007_043 · Cited by 26 · see citing works

Whole-Mount In Situ Hybridization in AmphimedonPreprint

Larroux, C., Fahey, B., Adamska, M., Richards, G. S., Gauthier, M., Green, K., Lovas, E. M., & Degnan, B. M. (2008) · Cold Spring Harbor Protocols · doi:10.1101/pdb.prot5096 · Cited by 21 · see citing works

Analysis of Cell Movement in Amphimedon Embryos by Injection of Fluorescent TracersPreprint

Adamska, M., & Degnan, B. M. (2008) · Cold Spring Harbor Protocols · doi:10.1101/pdb.prot5097 · Cited by 5 · see citing works

The Analysis of Eight Transcriptomes from All Poriferan Classes Reveals Surprising Genetic Complexity in Sponges

Riesgo, A., Farrar, N., Windsor, P. J., Giribet, G., & Leys, S. P. (2014) · Molecular Biology and Evolution · doi:10.1093/molbev/msu057 · Cited by 266 · see citing works

Independent evolution of striated muscles in cnidarians and bilaterians

Steinmetz, P. R. H., Kraus, J. E. M., Larroux, C., Hammel, J. U., Amon-Hassenzahl, A., Houliston, E., Wörheide, G., Nickel, M., Degnan, B. M., & Technau, U. (2012) · Nature · doi:10.1038/nature11180 · Cited by 252 · see citing works

The hidden biology of sponges and ctenophores

Dunn, C. W., Leys, S. P., & Haddock, S. H. D. (2015) · Trends in Ecology &amp; Evolution · doi:10.1016/j.tree.2015.03.003 · Cited by 212 · see citing works

The Genomic and Cellular Foundations of Animal Origins

Richter, D. J., & King, N. (2013) · Annual Review of Genetics · doi:10.1146/annurev-genet-111212-133456 · Cited by 196 · see citing works

The Evolutionary History of YAP and the Hippo/YAP Pathway

Hilman, D., & Gat, U. (2011) · Molecular Biology and Evolution · doi:10.1093/molbev/msr065 · Cited by 166 · see citing works

Deep Phylogeny and Evolution of Sponges (Phylum Porifera)

Wörheide, G., Dohrmann, M., Erpenbeck, D., Larroux, C., Maldonado, M., Voigt, O., Borchiellini, C., & Lavrov, D. V. (2012) · Advances in Marine Biology · doi:10.1016/b978-0-12-387787-1.00007-6 · Cited by 166 · see citing works

Elements of a ‘nervous system’ in sponges

Leys, S. P. (2015) · Journal of Experimental Biology · doi:10.1242/jeb.110817 · Cited by 138 · see citing works

Neuroglialpharmacology: Myelination as a shared mechanism of action of psychotropic treatments

Bartzokis, G. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.01.015 · Cited by 142 · see citing works

Developmental gene expression provides clues to relationships between sponge and eumetazoan body plans

Leininger, S., Adamski, M., Bergum, B., Guder, C., Liu, J., Laplante, M., Bråte, J., Hoffmann, F., Fortunato, S., Jordal, S., et al. (2014) · Nature Communications · doi:10.1038/ncomms4905 · Cited by 136 · see citing works

Origin of Metazoan Developmental Toolkits and Their Expression in the Fossil Record

Tweedt, S. M., & Erwin, D. H. (2015) · Advances in Marine Genomics · doi:10.1007/978-94-017-9642-2_3 · Cited by 27 · see citing works

Frizzled and LRP5/6 Receptors for Wnt/ -Catenin SignalingPreprint

MacDonald, B. T., & He, X. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a007880 · Cited by 610 · see citing works

Oligomerization of Frizzled and LRP5/6 protein initiates intracellular signaling for the canonical WNT/β-catenin pathway

Hua, Y., Yang, Y., Li, Q., He, X., Zhu, W., Wang, J., & Gan, X. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.004434 · Cited by 75 · see citing works

Disruption of thetalin gene arrests mouse development at the gastrulation stage

Monkley, S. J., Zhou, X.-H., Kinston, S., Giblett, S. M., Hemmings, L., Priddle, H., Brown, J., Pritchard, C. A., Critchley, D. R., & F�ssler, R. (2000) · Developmental Dynamics · doi:10.1002/1097-0177(2000)9999:9999 · Cited by 218 · see citing works

Faculty Opinions recommendation of Initiation of Wnt signaling: control of Wnt coreceptor Lrp6 phosphorylation/activation via frizzled, dishevelled and axin functions.

Kimelman, D. (2007) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.1097375.553421

Cholesterol Binding is a Determinant of Canonical Wnt Signaling Activity of Dishevelled

Sheng, R. (2013) · The FASEB Journal · doi:10.1096/fasebj.27.1_supplement.813.10