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Cited by 1,215

The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.

A putative flip–flop switch for control of REM sleep

Lu, Jun, Sherman, David, Devor, Marshall, Saper, Clifford B.·2006·Nature
DOI 10.1038/nature04767
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Show all 7 references

Research works printed but not linked: 32

  1. McCarley, R. W. Mechanisms and models of REM sleep control. Arch. Ital. Biol. 142, 429–467 (2004)
  2. Steriade, M., Pare, D., Datta, S., Oakson, G. & Curro Dossi, R. Different cellular types in mesopontine cholinergic nuclei related to ponto-geniculo-occipital waves. J. Neurosci. 10, 2560–2579 (1990) · DOI
  3. Wu, M. F. et al. Activity of dorsal raphe cells across the wake–sleep cycle and during cataplexy in narcoleptic dogs. J. Physiol. (Lond.) 554, 202–215 (2004) · DOI
  4. Hobson, J. A., McCarley, R. W. & Nelson, J. P. Location and spike-train characteristics of cells in anterodorsal pons having selective decreases in firing rate during desynchronized sleep. J. Neurophysiol. 50, 770–783 (1983) · DOI
  5. Kubin, L. Carbachol models of REM sleep: recent developments and new directions. Arch. Ital. Biol. 139, 147–168 (2001)
  6. Coleman, C. G., Lydic, R. & Baghdoyan, H. A. M2 muscarinic receptors in pontine reticular formation of C57BL/6J mouse contribute to rapid eye movement sleep generation. Neuroscience 126, 821–830 (2004) · DOI
  7. Wilson, S. & Argyropoulos, S. Antidepressants and sleep: a qualitative review of the literature. Drugs 65, 927–947 (2005) · DOI · Paper page
  8. Jones, B. E., Harper, S. T. & Halaris, A. E. Effects of locus coeruleus lesions upon cerebral monoamine content, sleep–wakefulness states and the response to amphetamine in the cat. Brain Res. 124, 473–496 (1977) · DOI · Paper page
  9. Mouret, J. & Coindet, J. Polygraphic evidence against a critical role of the raphe nuclei in sleep in the rat. Brain Res. 186, 273–287 (1980) · DOI
  10. Shouse, M. N. & Siegel, J. M. Pontine regulation of REM sleep components in cats: integrity of the pedunculopontine tegmentum (PPT) is important for phasic events but unnecessary for atonia during REM sleep. Brain Res. 571, 50–63 (1992) · DOI
  11. Lee, M. G., Hassani, O. K. & Jones, B. E. Discharge of identified orexin/hypocretin neurons across the wake–sleep cycle. J. Neurosci. 25, 6716–6720 (2005) · DOI · Paper page
  12. Mileykovskiy, B. Y., Kiyashchenko, L. I. & Siegel, J. M. Behavioral correlates of activity in identified hypocretin/orexin neurons. Neuron 46, 787–798 (2005) · DOI · Paper page
  13. Thannickal, T. C. et al. Reduced number of hypocretin neurons in human narcolepsy. Neuron 27, 469–474 (2000) · DOI · Paper page
  14. Lu, J. et al. Selective activation of the extended ventrolateral preoptic nucleus during rapid eye movement sleep. J. Neurosci. 22, 4568–4576 (2002) · DOI · Paper page
  15. Sastre, J. P., Buda, C., Kitahama, K. & Jouvet, M. Importance of the ventrolateral region of the periaqueductal gray and adjacent tegmentum in the control of paradoxical sleep as studied by muscimol microinjections in the cat. Neuroscience 74, 415–426 (1996) · DOI
  16. Boissard, R. et al. The rat ponto-medullary network responsible for paradoxical sleep onset and maintenance: a combined microinjection and functional neuroanatomical study. Eur. J. Neurosci. 16, 1959–1973 (2002) · DOI · Paper page
  17. Sakai, K., Crochet, S. & Onoe, H. Pontine structures and mechanisms involved in the generation of paradoxical (REM) sleep. Arch. Ital. Biol. 139, 93–107 (2001)
  18. Onoe, H. & Sakai, K. Kainate receptors: a novel mechanism in paradoxical (REM) sleep generation. Neuroreport 6, 353–356 (1995) · DOI
  19. Boissard, R. et al. Localization of the GABAergic and non-GABAergic neurons projecting to the sublaterodorsal nucleus and potentially gating paradoxical sleep onset. Eur. J. Neurosci. 18, 1627–1639 (2003) · DOI
  20. Saper, C. B., Chou, T. C. & Scammell, T. E. The sleep switch: hypothalamic control of sleep and wakefulness. Trends Neurosci. 24, 726–731 (2001) · DOI · Paper page
  21. Sastre, J. P. & Jouvet, M. Oneiric behavior in cats. Physiol. Behav. 22, 979–989 (1979) · DOI
  22. Sanford, L. D. et al. Sleep patterning and behaviour in cats with pontine lesions creating REM without atonia. J. Sleep Res. 3, 233–240 (1994) · DOI
  23. Plazzi, G. et al. Pontine lesions in idiopathic narcolepsy. Neurology 46, 1250–1254 (1996) · DOI
  24. Rye, D. B. et al. Medullary and spinal efferents of the pedunculopontine tegmental nucleus and adjacent mesopontine tegmentum in the rat. J. Comp. Neurol. 269, 315–341 (1988) · DOI · Paper page
  25. Sastre, J. P., Sakai, K. & Jouvet, M. Are the gigantocellular tegmental field neurons responsible for paradoxical sleep? Brain Res. 229, 147–161 (1981) · DOI
  26. Taal, W. & Holstege, J. C. GABA and glycine frequently colocalize in terminals on cat spinal motoneurons. Neuroreport 5, 2225–2228 (1994) · DOI
  27. Chase, M. H., Soja, P. J. & Morales, F. R. Evidence that glycine mediates the postsynaptic potentials that inhibit lumbar motoneurons during the atonia of active sleep. J. Neurosci. 9, 743–751 (1989) · DOI
  28. Kapas, L. et al. The effects of immunolesions of nerve growth factor-receptive neurons by 192 IgG–saporin on sleep. Brain Res. 712, 53–59 (1996) · DOI
  29. Gerashchenko, D., Salin-Pascual, R. & Shiromani, P. J. Effects of hypocretin–saporin injections into the medial septum on sleep and hippocampal theta. Brain Res. 913, 106–115 (2001) · DOI
  30. Manford, M. & Andermann, F. Complex visual hallucinations. Clinical and neurobiological insights. Brain 21, 1819–1840 (1998) · DOI · Paper page
  31. Kimura, K. et al. A discrete pontine ischemic lesion could cause REM sleep behavior disorder. Neurology 55, 894–895 (2000) · DOI
  32. Braak, H. et al. Parkinson's disease: affection of brain stem nuclei controlling premotor and motor neurons of the somatomotor system. Acta Neuropathol. (Berl.) 99, 489–495 (2000) · DOI

Cited by

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Metadata

Authors
Lu, J., Sherman, D., Devor, M., & Saper, C. B.
Venue
Nature
Publisher
Springer Science and Business Media LLC
Published
2006-05-10
Volume
441
Issue
7093
Pages
589-594
ISSN
  • 0028-0836 (ISSN-L)
  • 1476-4687
DOI
10.1038/nature04767
OpenAlex
W2027429673
Cited by
1,215
References
7
FWCI
30.40
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)

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Lu, J., Sherman, D., Devor, M., & Saper, C. B. (2006). A putative flip–flop switch for control of REM sleep. Nature. https://doi.org/10.1038/nature04767

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