Hypoxia signalling in cancer and approaches to enforce tumour regression

The biology of VEGF and its receptors

Ferrara, N., Gerber, H.-P., & LeCouter, J. (2003) · Nature Medicine · doi:10.1038/nm0603-669 · Cited by 9,591

Targeting HIF-1 for cancer therapy

Semenza, G. L. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1187 · Cited by 6,717

Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O 2 -Regulated Prolyl Hydroxylation

Jaakkola, P., Mole, D. R., Tian, Y.-M., Wilson, M. I., Gielbert, J., Gaskell, S. J., Kriegsheim, A. V., Hebestreit, H. F., Mukherji, M., Schofield, C. J., et al. (2001) · Science · doi:10.1126/science.1059796 · Cited by 5,535

Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene

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Angiopoietin-2, a Natural Antagonist for Tie2 That Disrupts in vivo Angiogenesis

Maisonpierre, P. C., Suri, C., Jones, P. F., Bartunkova, S., Wiegand, S. J., Radziejewski, C., Compton, D., McClain, J., Aldrich, T. H., Papadopoulos, N., et al. (1997) · Science · doi:10.1126/science.277.5322.55 · Cited by 3,570

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

Epstein, A. C. R., Gleadle, J. M., McNeill, L. A., Hewitson, K. S., O'Rourke, J., Mole, D. R., Mukherji, M., Metzen, E., Wilson, M. I., Dhanda, A., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00507-4 · Cited by 3,333

VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia

Gerhardt, H., Golding, M., Fruttiger, M., Ruhrberg, C., Lundkvist, A., Abramsson, A., Jeltsch, M., Mitchell, C., Alitalo, K., Shima, D., et al. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200302047 · Cited by 2,894

AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism

Kahn, B. B., Alquier, T., Carling, D., & Hardie, D. G. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2004.12.003 · Cited by 2,799

Angiogenesis as a therapeutic target

Ferrara, N., & Kerbel, R. S. (2005) · Nature · doi:10.1038/nature04483 · Cited by 2,653

Dolastatin 15 from a Marine Cyanobacterium Suppresses HIF‐1α Mediated Cancer Cell Viability and Vascularization

Ratnayake, R., Gunasekera, S. P., Ma, J., Dang, L. H., Carney, T. J., Paul, V. J., & Luesch, H. (2020) · ChemBioChem · doi:10.1002/cbic.202000180 · Cited by 27

Heparin modified photosensitizer-loaded liposomes for tumor treatment and alleviating metastasis in phototherapy

Cao, D., Li, H., Luo, Y., Feng, N., & Ci, T. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.12.043 · Cited by 27

A vasculature-centric approach to developing novel treatment options for glioblastoma

Wirsching, H., Roth, P., & Weller, M. (2021) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2021.1881062 · Cited by 26

Hypoxia Induced by Cobalt Chloride Triggers Autophagic Apoptosis of Human and Mouse Drug‐Resistant Glioblastoma Cells through Targeting the PI3K‐AKT‐mTOR Signaling Pathway

Lee, Y., Cherng, Y., Yang, S., Liu, S., Chen, T.-L., & Chen, R. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/5558618 · Cited by 28

Understanding the role of potential pathways and its components including hypoxia and immune system in case of oral cancer

Bajrai, L. H., Sohrab, S. S., Mobashir, M., Kamal, M. A., Rizvi, M. M. A., & Azhar, E. I. (2021) · Scientific Reports · doi:10.1038/s41598-021-98031-7 · Cited by 30

Novel Thiopyrano[2,3- d ]thiazole-pyrazole Hybrids as Potential Nonsulfonamide Human Carbonic Anhydrase IX and XII Inhibitors: Design, Synthesis, and Biochemical Studies

Metwally, N. H., & El-Desoky, E. A. (2023) · ACS Omega · doi:10.1021/acsomega.2c06954 · Cited by 27

Interaction of gut microbiota with the tumor microenvironment: A new strategy for antitumor treatment and traditional Chinese medicine in colorectal cancer

Li, T., Han, L., Ma, S., Lin, W., Ba, X. W., Yan, J., Huang, Y., Tu, S., & Qin, K. (2023) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2023.1140325 · Cited by 27

The Effect of Cell–Matrix Interactions and Aging on the Malignant Process

Labat‐Robert, J., & Robert, L. (2007) · Advances in cancer research · doi:10.1016/s0065-230x(06)98007-5 · Cited by 27

Hypoxia attenuates the proinflammatory response in colon cancer cells by regulating IκB

Müller-Edenborn, K., Léger, K., Garzon, J. F. G., Oertli, C., Mirsaidi, A., Richards, P. J., Rehrauer, H., Spielmann, P., Hoogewijs, D., Borsig, L., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.3961 · Cited by 27

Prognostic Impacts of Hypoxic Markers in Soft Tissue Sarcoma

Smeland, E., Kilvaer, T. K., Sørbye, S. W., Valkov, A., Andersen, S., Bremnes, R. M., Busund, L., & Dønnem, T. (2012) · Sarcoma · doi:10.1155/2012/541650 · Cited by 27

HIF-1–Dependent Stromal Adaptation to Ischemia Mediates In Vivo Tumor Radiation Resistance

Schwartz, D. L., Bankson, J. A., Bidaut, L. M., He, Y., Williams, R. R., Lemos, R., Thitai, A. K., Oh, J., Volgin, A., Soghomonyan, S., et al. (2011) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-10-0469 · Cited by 27

Cancer cell aggregate hypoxia visualized in vitro via biocompatible fiber sensors

Xue, R., Nelson, M. T., Teixeira, S. A., Viapiano, M. S., & Lannutti, J. J. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2015.10.055 · Cited by 27

Hypoxia inducible factor-1 alpha and multiple myeloma.

Bhaskar, A., & Tiwary, B. N. (2016) · PubMed · Cited by 27

Respiratory stress in mitochondrial electron transport chain complex mutants of Candida albicans activates Snf1 kinase response

Zhang, P., Li, H., Cheng, J., Sun, A., Wang, L., Мирчевска, Г., Calderone, R., & Li, D. (2017) · Fungal Genetics and Biology · doi:10.1016/j.fgb.2017.11.002 · Cited by 26

Blood and Tissue Enzymatic Activities of GDH and LDH, Index of Glutathione, and Oxidative Stress among Breast Cancer Patients Attending Referral Hospitals of Addis Ababa, Ethiopia: Hospital‐Based Comparative Cross‐Sectional Study

Mehdi, M., Menon, M. K. C., Seyoum, N., Bekele, M., Tigeneh, W., & Seifu, D. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/6039453 · Cited by 27

Reciprocal loop of hypoxia‐inducible factor‐1α (HIF‐1α) and metastasis‐associated protein 2 (MTA2) contributes to the progression of pancreatic carcinoma by suppressing E‐cadherin transcription

Zhu, S., Deng, S.-J., He, C., Liu, M., Chen, H., Zeng, Z., Zhong, J., Zeng, Y., Deng, S., Wu, H., et al. (2018) · The Journal of Pathology · doi:10.1002/path.5089 · Cited by 27

Reactive Oxygen Species Signaling Promotes Hypoxia-Inducible Factor 1 α Stabilization in Sonic Hedgehog-Driven Cerebellar Progenitor Cell Proliferation

Eyrich, N. W., Potts, C. R., Robinson, M. H., Maximov, V. D., & Kenney, A. M. (2019) · Molecular and Cellular Biology · doi:10.1128/mcb.00268-18 · Cited by 27

Anti‐angiogenic properties of myo‐inositol trispyrophosphate in ovo and growth reduction of implanted glioma

Sihn, G., Walter, T., Klein, J.-C., Quéguiner, I., Iwao, H., Nicolau, C. S., Lehn, J., Corvol, P. L., & Gasc, J. (2007) · FEBS Letters · doi:10.1016/j.febslet.2007.01.079 · Cited by 27

Imaging of hypoxia-driven gene expression in an orthotopic liver tumor model

Brader, P., Riedl, C. C., Woo, Y., Ponomarev, V., ZANZONICO, P. B., Wen, B., Cai, S., Hricak, H., Fong, Y., Blasberg, R., et al. (2007) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-07-0432 · Cited by 27

Polyacetal-stilbene conjugates — The first examples of polymer therapeutics for the inhibition of HIF-1 in the treatment of solid tumours

England, R., Masiá, E., Giménez, V., Lucas-Domínguez, R., & Vicent, M. J. (2012) · Journal of Controlled Release · doi:10.1016/j.jconrel.2012.08.017 · Cited by 26

An Early Diagnostic Tool for Diabetic Peripheral Neuropathy in Rats

Kambiz, S., van Neck, J. W., Cosgun, S. G., van Velzen, M. H. N., Janssen, J. A. M. J. L., Avazverdi, N., Hovius, S. E. R., & Walbeehm, E. T. (2015) · PLoS ONE · doi:10.1371/journal.pone.0126892 · Cited by 26

Isoliquiritin Apioside Suppresses in vitro Invasiveness and Angiogenesis of Cancer Cells and Endothelial Cells

Kim, A., & Yeul, J. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.01455 · Cited by 26

Activation of amino acid metabolic program in cardiac HIF1-alpha-deficient mice

Menendez-Montes, I., Escobar, B., Gómez, M. J., Albendea-Gomez, T., Palacios, B., Bonzón‐Kulichenko, E., Izquierdo-García, J. L., Alonso, A. V., Ferrarini, A., Jiménez‐Borreguero, L. J., et al. (2021) · iScience · doi:10.1016/j.isci.2021.102124 · Cited by 25

Phase Ib dose-escalation study of the hypoxia-modifier Myo-inositol trispyrophosphate in patients with hepatopancreatobiliary tumors

Schneider, M. A., Linecker, M., Fritsch, R., Muehlematter, U. J., Stocker, D., Pestalozzi, B. C., Samaras, P., Jetter, A., Kron, P., Petrowsky, H., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-24069-w · Cited by 26

Electrogenic sodium bicarbonate cotransporter NBCe1 regulates pancreatic β cell function in type 2 diabetes

Brown, M., Holmes, H. L., Rakshit, K., Javeed, N., Her, T. K., Stiller, A. A., Sen, S., Shull, G. E., Prakash, Y. S., Romero, M. F., et al. (2021) · Journal of Clinical Investigation · doi:10.1172/jci142365 · Cited by 26

NeuroD1 promotes tumor cell proliferation and tumorigenesis by directly activating the pentose phosphate pathway in colorectal carcinoma

Li, Z., He, Y., Li, Y., Li, J., Zhao, H., Guan-bing, S., Miyagishi, M., Wu, S., & Kasim, V. (2021) · Oncogene · doi:10.1038/s41388-021-02063-2 · Cited by 26

Five hypoxia and immunity related genes as potential biomarkers for the prognosis of osteosarcoma

Liu, D., Hu, Z., Jiang, J., Zhang, J., Hu, C., Huang, J., & Wei, Q. (2022) · Scientific Reports · doi:10.1038/s41598-022-05103-3 · Cited by 24

Recent Advancements on Self‐Immolative System Based on Dynamic Covalent Bonds for Delivering Heterogeneous Payloads

Wang, Q., Serda, M., Li, Q., & Sun, T. (2023) · Advanced Healthcare Materials · doi:10.1002/adhm.202300138 · Cited by 26

HIF-1α suppressing small molecule, LW6, inhibits cancer cell growth by binding to calcineurin b homologous protein 1

Kim, B. S., Lee, K., Jung, H. J., Bhattarai, D., & Kwon, H. J. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.01.031 · Cited by 26

PHD4 Stimulates Tumor Angiogenesis in Osteosarcoma Cells via TGF-α

Ameln, A. K., Prade, I., Großer, M., Kettelhake, A., Rezaei, M., Chavakis, T., Flamme, I., Wielockx, B., & Breier, G. (2013) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-13-0201 · Cited by 26

Interaction of HIF and USF Signaling Pathways in Human Genes Flanked by Hypoxia-Response Elements and E-box Palindromes

Hu, J., Stiehl, D. P., Setzer, C., Wichmann, D., Shinde, D. A., Rehrauer, H., Hradecky, P., Gassmann, M., & Gorr, T. A. (2011) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-11-0090 · Cited by 28

Inhibition of Carbonic Anhydrase IX by Ureidosulfonamide Inhibitor U104 Reduces Prostate Cancer Cell Growth, But Does Not Modulate Daunorubicin or Cisplatin Cytotoxicity

Riemann, A., Güttler, A., Haupt, V., Wichmann, H., Reime, S., Bache, M., Vordermark, D., & Thews, O. (2017) · Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics · doi:10.3727/096504017x14965111926391 · Cited by 26

Orexin A affects HepG2 human hepatocellular carcinoma cells glucose metabolism via HIF-1α-dependent and -independent mechanism

Wan, X., Liu, Y., Zhao, Y., Sun, X., Fan, D., & Guo, L. (2017) · PLoS ONE · doi:10.1371/journal.pone.0184213 · Cited by 27

The molecular rationale for therapeutic targeting of glutamine metabolism in pulmonary hypertension

Bertero, T., Perk, D., & Chan, S. Y. (2019) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2019.1615438 · Cited by 26

Combination of immunotherapy with anaerobic bacteria for immunogene therapy of solid tumours

Xu, J., Liu, X. S., Zhou, S., & Wei, M. Q. (2009) · Griffith Research Online · Cited by 26

Onconeuronal cerebellar degeneration-related antigen, Cdr2, is strongly expressed in papillary renal cell carcinoma and leads to attenuated hypoxic response

Balamurugan, K., Luu, V.-D., Kaufmann, M., Hofmann, V. S., Boysen, G., Barth, S., Bordoli, M. R., Stiehl, D. P., Moch, H., Schraml, P., et al. (2009) · Oncogene · doi:10.1038/onc.2009.186 · Cited by 26

Hypoxia-induced Wnt5a-secreting fibroblasts promote colon cancer progression

Harada, A., Yasumizu, Y., Harada, T., Fumoto, K., Sato, A., Maehara, N., Sada, R., Matsumoto, S., Nishina, T., Takeda, K., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-58748-9 · Cited by 25

The paradox of elongation factor 4: highly conserved, yet of no physiological significance?

Zhang, D., & Qin, Y. (2013) · Biochemical Journal · doi:10.1042/bj20121792 · Cited by 25

Cancer Exosomes as Mediators of Drug Resistance

André, M. D. R., Pedro, A. B. P., & Lyden, D. C. (2016) · Methods in molecular biology · doi:10.1007/978-1-4939-3347-1_13 · Cited by 25

Vasohibin1, a new mouse cardiomyocyte IRES trans-acting factor that regulates translation in early hypoxia

Hantelys, F., Godet, A.-C., David, F., Tatin, F., Renaud-Gabardos, E., Pujol, F., Diallo, L. H., Ader, I., Ligat, L., Henras, A. K., et al. (2019) · eLife · doi:10.7554/elife.50094 · Cited by 25

HDAC6-specific inhibitor suppresses Th17 cell function via the HIF-1α pathway in acute lung allograft rejection in mice

Zhou, W., Yang, J., Saren, G., Zhao, H., Cao, K., Fu, S., Pan, X., Zhang, H., Wang, A., & Chen, X. (2020) · Theranostics · doi:10.7150/thno.44961 · Cited by 26

Crosstalk between hypoxia-sensing ULK1/2 and YAP-driven glycolysis fuels pancreatic ductal adenocarcinoma development

Jia, Y., Li, H., Wang, Y., Wang, J., Zhu, J., Wei, Y., Lu, L., Chen, X., & Mo, S. (2021) · International Journal of Biological Sciences · doi:10.7150/ijbs.60018 · Cited by 26

On the Evaluation of a Novel Hypoxic 3D Pancreatic Cancer Model as a Tool for Radiotherapy Treatment Screening

Wishart, G., Gupta, P., Nisbet, A., Schettino, G., & Velliou, E. G. (2021) · Cancers · doi:10.3390/cancers13236080 · Cited by 26

How germline genes promote malignancy in cancer cells

Bruggeman, J. W., Köster, J., van Pelt, A. M. M., Speijer, D., & Hamer, G. (2022) · BioEssays · doi:10.1002/bies.202200112 · Cited by 28

Long non-coding RNA Neat1 and paraspeckle components are translational regulators in hypoxia

Godet, A.-C., Roussel, É., David, F., Hantelys, F., Morfoisse, F., Alves, J., Pujol, F., Ader, I., Bertrand, É., Burlet‐Schiltz, O., et al. (2022) · eLife · doi:10.7554/elife.69162 · Cited by 27

PBX3 promotes pentose phosphate pathway and colorectal cancer progression by enhancing G6PD expression

Luo, X., Wei, M., Li, W., Zhao, H., Kasim, V., & Wu, S. (2023) · International Journal of Biological Sciences · doi:10.7150/ijbs.86279 · Cited by 26

KS900: A hypoxia-directed, reductively activated methylating antitumor prodrug that selectively ablates O6-alkylguanine-DNA alkyltransferase in neoplastic cells

Baumann, R. P., Ishiguro, K., Penketh, P. G., Shyam, K., Zhu, R., & Sartorelli, A. C. (2011) · Biochemical Pharmacology · doi:10.1016/j.bcp.2011.02.019 · Cited by 25

Validation of an immunohistochemical signature predictive of 8‐year outcome for patients with breast carcinoma

Charpin, C., Tavassoli, F. A., Secq, V., Giusiano, S., Villeret, J., Garcia, S., Birnbaum, D., Bonnier, P., Lavaut, M., Boubli, L., et al. (2011) · International Journal of Cancer · doi:10.1002/ijc.27371 · Cited by 25

Transcriptional adaptation of neuroblastoma cells to hypoxia

Fredlund, E., Ovenberger, M., Borg, Å., & Påhlman, S. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.12.074 · Cited by 25

Prognostic impact of SUMO-specific protease 1 (SENP1) in prostate cancer patients undergoing radical prostatectomy

Li, T., Huang, S., Dong, M., Gui, Y., & Wu, D. (2012) · Urologic Oncology Seminars and Original Investigations · doi:10.1016/j.urolonc.2012.03.007 · Cited by 25

In papillary thyroid carcinoma, TIMP-1 expression correlates with BRAF V600E mutation status and together with hypoxia-related proteins predicts aggressive behavior

Ilié, M., Lassalle, S., Long-Mira, É., Hofman, V., Zangari, J., Benaïm, G., Bozec, A., Guevara, N., Haudebourg, J., Birtwisle‐Peyrottes, I., et al. (2013) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/s00428-013-1453-x · Cited by 25

Metabolic effects of antiangiogenic drugs in tumors: Therapeutic implications

Quintieri, L., Selmy, M., & Indraccolo, S. (2014) · Biochemical Pharmacology · doi:10.1016/j.bcp.2014.02.018 · Cited by 25

The Roles of Hypoxia-Inducible Factors in Regulating Neural Stem Cells Migration to Glioma Stem Cells and Determinating Their Fates

Zhang, S., Luo, X., Wan, F., & Lei, T. (2012) · Neurochemical Research · doi:10.1007/s11064-012-0879-x · Cited by 27

Retinoic acid receptor‐related orphan receptor RORα regulates differentiation and survival of keratinocytes during hypoxia

Li, H., Zhou, L., & Dai, J. (2017) · Journal of Cellular Physiology · doi:10.1002/jcp.25924 · Cited by 25

Delanzomib Interacts with Ritonavir Synergistically to Cause Endoplasmic Reticulum Stress in Renal Cancer Cells

Isono, M., Sato, A., Asano, T., Okubo, K., & Asano, T. (2018) · Anticancer Research · doi:10.21873/anticanres.12620 · Cited by 25

Epithelial and Mesenchymal Tumor Compartments Exhibit In Vivo Complementary Patterns of Vascular Perfusion and Glucose Metabolism

Galiè, M., Farace, P., Nanni, C., Spinelli, A. E., Nicolato, E., Boschi, F., Magnani, P., Trespidi, S., Ambrosini, V., Fanti, S., et al. (2007) · Neoplasia · doi:10.1593/neo.07541 · Cited by 25

Response of CAIX and CAXII to in vitro re-oxygenation and clinical significance of the combined expression in NSCLC patients

Ilié, M., Hofman, V., Zangari, J., Chiche, J., Mouroux, J., Mazure, N. M., Pouysségur, J., Brest, P., & Hofman, P. M. (2013) · Lung Cancer · doi:10.1016/j.lungcan.2013.07.005 · Cited by 25

Conditional Inactivation of HIF-1 Using Intrabodies

Groot, A. J., Gort, E. H., van der Wall, E., van Diest, P. J., & Vooijs, M. (2008) · Analytical Cellular Pathology · doi:10.1155/2008/384945 · Cited by 25

Dihydroartemisinin inhibits melanoma migration and metastasis by affecting angiogenesis

Li, Z., Zhang, Q., Zhang, X., Jin, Q., Yue, Q., Li, N., Liu, H., Fujimoto, M., & Jin, G. (2023) · Phytotherapy Research · doi:10.1002/ptr.8065 · Cited by 24

Sensor-based cell and tissue screening for personalized cancer chemotherapy

Kleinhans, R., Brischwein, M., Wang, P., Becker, B., Demmel, F., Schwarzenberger, T., Zottmann, M., Wolf, P. S., Niendorf, A., & Wolf, B. A. (2012) · Medical & Biological Engineering & Computing · doi:10.1007/s11517-011-0855-7 · Cited by 24

Comparing progression molecular mechanisms between lung adenocarcinoma and lung squamous cell carcinoma based on genetic and epigenetic networks: big data mining and genome-wide systems identification

Yeh, S., Chang, C.-A., Li, C., Wang, L. H.-C., & Chen, B. (2019) · Oncotarget · doi:10.18632/oncotarget.26940 · Cited by 24

Role of Bladder Cancer Metabolic Reprogramming in the Effectiveness of Immunotherapy

Scholtes, M., de Jong, F. C., Zuiverloon, T. C. M., & Theodorescu, D. (2021) · Cancers · doi:10.3390/cancers13020288 · Cited by 24

Tau Protein as Therapeutic Target for Cancer? Focus on Glioblastoma

Hedna, R., Kovacic, H., Pagano, A., Peyrot, V., Robin, M., Devred, F., & Breuzard, G. (2022) · Cancers · doi:10.3390/cancers14215386 · Cited by 25

Involvement of redox signalling in tumour cell dormancy and metastasis

Puente-Cobacho, B., Varela‐López, A., Quiles, J. L., & Ramírez, L. V. (2023) · Cancer and Metastasis Reviews · doi:10.1007/s10555-022-10077-9 · Cited by 25

Hypoxia and HIFs in Ewing sarcoma: new perspectives on a multi-facetted relationship

Ceranski, A. K., Carreño-Gonzalez, M. J., Ehlers, A. C., Colombo, M. V., Cidre‐Aranaz, F., & Grünewald, T. G. P. (2023) · Molecular Cancer · doi:10.1186/s12943-023-01750-w · Cited by 25

Diagnostic, Prognostic, and Therapeutic Role for Angiogenesis Markers in Head and Neck Squamous Cell Carcinoma: A Narrative Review

Alessandrini, L., Astolfi, L., Daloiso, A., Sbaraglia, M., Mondello, T., Zanoletti, E., Franz, L., & Marioni, G. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241310733 · Cited by 24

Acidosis-induced regulation of adipocyte G0S2 promotes crosstalk between adipocytes and breast cancer cells as well as tumor progression

Crémer, J., Brohée, L., Dupont, L., Lefevre, C., Peiffer, R., Saarinen, A. M., Peulen, O., Bindels, L. B., Liu, J., Colige, A., et al. (2023) · Cancer Letters · doi:10.1016/j.canlet.2023.216306 · Cited by 24

Bioactive food components, cancer cell growth limitation and reversal of glycolytic metabolism

Keijer, J., Bekkenkamp‐Grovenstein, M., Venema, D. P., & Dommels, Y. E. M. (2010) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2010.08.007 · Cited by 25

Germline prognostic markers for urinary bladder cancer: Obstacles and opportunities

Chang, D. W., Gu, J. H., & Wu, X. (2012) · Urologic Oncology Seminars and Original Investigations · doi:10.1016/j.urolonc.2012.04.003 · Cited by 24

Sumoylation of hypoxia inducible factor-1α and its significance in cancer

Li, J., Xu, Y., Jiao, H., Wang, W., Mei, Z., & Chen, G. (2014) · Science China Life Sciences · doi:10.1007/s11427-014-4685-3 · Cited by 25

Protein arginine methyltransferase 5 is an essential component of the hypoxia-inducible factor 1 signaling pathway

Lim, J.-H., Choi, Y.-J., Cho, C., & Park, J. (2012) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2012.01.006 · Cited by 24

Silencing of hypoxia-inducible factor-1α promotes thyroid cancer cell apoptosis and inhibits invasion by downregulating WWP2, WWP9, VEGF and VEGFR2

Ding, Z., Huang, Y.-J., Tang, J., Li, G., Jiang, P.-Q., & Wu, H. (2016) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2016.3826 · Cited by 24

Plasminogen kringle 5 suppresses gastric cancer via regulating HIF-1α and GRP78

Fang, S., Hong, H., Li, L., He, D., Xu, Z., Shaoyuan, Z., Han, J., Wu, Q., Dai, Z., Cai, W., et al. (2017) · Cell Death and Disease · doi:10.1038/cddis.2017.528 · Cited by 24

Construction of a chromosome 17 transcriptome in serous ovarian cancer identifies differentially expressed genes

Wojnarowicz, P. M., Breznan, A., Arcand, S. L., Filali-Mouhim, A., Provencher, D. M., Mes‐Masson, A., & Tonin, P. N. (2007) · International Journal of Gynecological Cancer · doi:10.1111/j.1525-1438.2007.01134.x · Cited by 24

Systemic administration of attenuated Salmonella typhimurium in combination with interleukin-21 for cancer therapy

Wang, Y., Chen, J., Tang, B., Zhang, X., & Hua, Z. (2013) · Molecular and Clinical Oncology · doi:10.3892/mco.2013.90 · Cited by 24

Visualization of Hypoxia-Inducible Factor-1 Transcriptional Activation in C6 Glioma Using Luciferase and Sodium Iodide Symporter Genes

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Hypoxia in health and disease

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