Hypoxia signalling in cancer and approaches to enforce tumour regression

The biology of VEGF and its receptors

Ferrara, N., Gerber, H.-P., & LeCouter, J. (2003) · Nature Medicine · doi:10.1038/nm0603-669 · Cited by 9,591

Targeting HIF-1 for cancer therapy

Semenza, G. L. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1187 · Cited by 6,717

Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O 2 -Regulated Prolyl Hydroxylation

Jaakkola, P., Mole, D. R., Tian, Y.-M., Wilson, M. I., Gielbert, J., Gaskell, S. J., Kriegsheim, A. V., Hebestreit, H. F., Mukherji, M., Schofield, C. J., et al. (2001) · Science · doi:10.1126/science.1059796 · Cited by 5,535

Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene

Ferrara, N., Carver-Moore, K., Chen, H., Dowd, M., Lu, L., O’Shea, K. S., Powell-Braxton, L., Hillan, K. J., & Moore, M. W. (1996) · Nature · doi:10.1038/380439a0 · Cited by 3,661

Angiopoietin-2, a Natural Antagonist for Tie2 That Disrupts in vivo Angiogenesis

Maisonpierre, P. C., Suri, C., Jones, P. F., Bartunkova, S., Wiegand, S. J., Radziejewski, C., Compton, D., McClain, J., Aldrich, T. H., Papadopoulos, N., et al. (1997) · Science · doi:10.1126/science.277.5322.55 · Cited by 3,570

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

Epstein, A. C. R., Gleadle, J. M., McNeill, L. A., Hewitson, K. S., O'Rourke, J., Mole, D. R., Mukherji, M., Metzen, E., Wilson, M. I., Dhanda, A., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00507-4 · Cited by 3,333

VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia

Gerhardt, H., Golding, M., Fruttiger, M., Ruhrberg, C., Lundkvist, A., Abramsson, A., Jeltsch, M., Mitchell, C., Alitalo, K., Shima, D., et al. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200302047 · Cited by 2,894

AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism

Kahn, B. B., Alquier, T., Carling, D., & Hardie, D. G. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2004.12.003 · Cited by 2,799

Angiogenesis as a therapeutic target

Ferrara, N., & Kerbel, R. S. (2005) · Nature · doi:10.1038/nature04483 · Cited by 2,653

Activated heme synthesis regulates glycolysis and oxidative metabolism in breast and ovarian cancer cells

Kaur, P., Nagar, S., Bhagwat, M., Uddin, M., Zhu, Y. B., Vancurova, I., & Vančura, A. (2021) · PLoS ONE · doi:10.1371/journal.pone.0260400 · Cited by 37

LDH-A influences hypoxia-inducible factor 1α (HIF1 α) and is critical for growth of HT29 colon carcinoma cells in vivo

Langhammer, S., Najjar, M., Hess‐Stumpp, H., & Thierauch, K. (2011) · Targeted Oncology · doi:10.1007/s11523-011-0184-7 · Cited by 36

Update on hypoxia-inducible factors and hydroxylases in oxygen regulatory pathways: from physiology to therapeutics

Ratcliffe, P. J., Koivunen, P., Myllyharju, J., Ragoussis, J., Bovée, J. V. M. G., Batinic̈‐Haberle, I., Vinatier, C. S., Trichet, V., Robriquet, F., Oliver, L., et al. (2017) · Hypoxia · doi:10.2147/hp.s127042 · Cited by 35

Diverse activity of miR-150 in Tumor development: shedding light on the potential mechanisms

Ameri, A., Ahmed, H. M., Pecho, R. D. C., Arabnozari, H., Sarabadani, H., Esbati, R., Mirabdali, S., & Yazdani, O. (2023) · Cancer Cell International · doi:10.1186/s12935-023-03105-3 · Cited by 35

Autophagy takes place in mutated p53 neuroblastoma cells in response to hypoxia mimetic CoCl2

Naves, T., Jawhari, S., Jauberteau, M., Ratinaud, M., & Verdier, M. (2013) · Biochemical Pharmacology · doi:10.1016/j.bcp.2013.01.022 · Cited by 39

Hypoxia Inducible Factor 3α Plays a Critical Role in Alveolarization and Distal Epithelial Cell Differentiation during Mouse Lung Development

Huang, Y., Ochieng, J. K., Kempen, M. B., Munck, A. B., Swagemakers, S. M. A., van IJcken, W. F. J., Grosveld, F. G., Tibboel, D., & Rottier, R. J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0057695 · Cited by 37

Hypoxia-driven splicing into noncoding isoforms regulates the DNA damage response

Memon, D., Dawson, K., Smowton, C., Wei, X., Dive, C., & Miller, C. J. (2016) · npj Genomic Medicine · doi:10.1038/npjgenmed.2016.20 · Cited by 36

HIF‐1α‐mediated BMP6 down‐regulation leads to hyperproliferation and abnormal differentiation of keratinocytes in vitro

Kim, J. H., Bae, H. C., Kim, J., Lee, H., Ryu, W., Son, E. D., Lee, T. R., Jeong, S. H., & Son, S. W. (2018) · Experimental Dermatology · doi:10.1111/exd.13785 · Cited by 35

Rapid effects of acute anoxia on spindle kinetochore interactions activate the mitotic spindle checkpoint

Pandey, R. K., Heeger, S., & Lehner, C. F. (2007) · Journal of Cell Science · doi:10.1242/jcs.007690 · Cited by 37

Iron and colorectal cancer: evidence from in vitro and animal studies

Padmanabhan, H., Brookes, M., & Iqbal, T. H. (2015) · Nutrition Reviews · doi:10.1093/nutrit/nuu015 · Cited by 35

Targeting carbonic anhydrase IX improves the anti-cancer efficacy of mTOR inhibitors

Faes, S., Planche, A., Uldry, É., Santoro, T., Pythoud, C., Stehle, J., Horlbeck, J., Letovanec, I., Riggi, N., Datta, D. B., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.9134 · Cited by 33

Harnessing cancer cell metabolism for theranostic applications using metabolic glycoengineering of sialic acid in breast cancer as a pioneering example

Badr, H. A., AlSadek, D. M. M., El-Houseini, M. E., Saeui, C. T., Mathew, M. P., Yarema, K. J., & Ahmed, H. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.11.044 · Cited by 34

Engineering biological gradients

Sardelli, L., Pacheco, D. P., Zorzetto, L., Rinoldi, C., Święszkowski, W., & Petrini, P. (2019) · Journal of Applied Biomaterials & Functional Materials · doi:10.1177/2280800019829023 · Cited by 35

Global extracellular vesicle proteomic signature defines U87-MG glioma cell hypoxic status with potential implications for non-invasive diagnostics

Chandran, V. I., Welinder, C., de Oliveira, K. G., Cerezo-Magaña, M., Månsson, A., Johansson, M. C., Marko‐Varga, G., & Belting, M. (2019) · Journal of Neuro-Oncology · doi:10.1007/s11060-019-03262-4 · Cited by 36

The transcription factor ZFHX3 is crucial for the angiogenic function of hypoxia-inducible factor 1α in liver cancer cells

Fu, C., An, N., Liu, J., Jun, A., Zhang, B., Liu, M., Zhang, Z., Fu, L., Tian, X., Wang, D., et al. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.012131 · Cited by 37

A Photosensitive Polymeric Carrier with a Renewable Singlet Oxygen Reservoir Regulated by Two NIR Beams for Enhanced Antitumor Phototherapy

Yang, C. F., Su, M., Luo, P., Liu, Y., Yang, F., & Li, C. (2021) · Small · doi:10.1002/smll.202101180 · Cited by 34

Hypoxia‐inducible factor‐1α blocks differentiation of malignant gliomas

Lu, H., Li, Y., Shu, M., Tang, J., Huang, Y., Zhou, Y., Liang, Y., & Yan, G. (2009) · FEBS Journal · doi:10.1111/j.1742-4658.2009.07441.x · Cited by 34

Uncovering the role of hypoxia inducible factor-1α in skin carcinogenesis

Nys, K., Maes, H., Dudek, A. M., & Agostinis, P. (2011) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2011.02.001 · Cited by 36

MicroRNA-513a-5p mediates TNF-α and LPS induced apoptosis via downregulation of X-linked inhibitor of apoptotic protein in endothelial cells

Shin, S.-J., Moon, K. C., Park, K. U., & Ha, E. (2012) · Biochimie · doi:10.1016/j.biochi.2012.03.023 · Cited by 34

Role Of Hif2α Oxygen Sensing Pathway In Bronchial Epithelial Club Cell Proliferation

Torres‐Capelli, M., Marsboom, G., Li, Q. O. Y., Tello, D., Meléndez‐Rodríguez, F., Alonso, T., Sánchez‐Madrid, F., Rio, F. G., Ancochea, J., & Aragonés, J. (2016) · Scientific Reports · doi:10.1038/srep25357 · Cited by 33

Hypoxia and the Presence of Human Vascular Endothelial Cells Affect Prostate Cancer Cell Invasion and Metabolism

Ackerstaff, E., Artemov, D., Gillies, R. J., & Bhujwalla, Z. M. (2007) · Neoplasia · doi:10.1593/neo.07568 · Cited by 34

Inhibition of aberrant Hif1α activation delays intervertebral disc degeneration in adult mice

Wang, Z., Chen, H., Tan, Q., Huang, J., Zhou, S., Luo, F., Zhang, D., Yang, J., Li, C., Chen, B., et al. (2022) · Bone Research · doi:10.1038/s41413-021-00165-x · Cited by 35

Immunogenic Radiation Therapy for Enhanced Antitumor Immunity via a Core–Shell Nanosensitizer-Mediated Immunosuppressive Tumor Microenvironment Modulation

Huang, N.-H., Tang, X., Meng, W., Lai, Y.-H., Zhou, X., Yu, X.-Z., Zhang, W., & Chen, J.-X. (2023) · ACS Nano · doi:10.1021/acsnano.3c04189 · Cited by 33

CD133 as a Marker for Regulation and Potential for Targeted Therapies in Glioblastoma Multiforme

Choy, W., Nagasawa, D. T., Trang, A., Thill, K., Spasić, M., & Yang, I. (2012) · Neurosurgery Clinics of North America · doi:10.1016/j.nec.2012.04.011 · Cited by 33

Hypoxia Promotes Nuclear Translocation and Transcriptional Function in the Oncogenic Tyrosine Kinase RON

Chang, H., Liu, H., Lai, M.-D., Tsai, Y., Tzai, T., Cheng, H.-L., & Chow, N.-H. (2014) · Cancer Research · doi:10.1158/0008-5472.can-13-3730 · Cited by 33

The clinicopathological and gene expression patterns associated with ulceration of primary melanoma

Jewell, R., Elliott, F., Laye, J. P., Nsengimana, J., Davies, J., Walker, C., Conway, C., Mitra, A., Harland, M., Cook, M. G., et al. (2014) · Pigment Cell & Melanoma Research · doi:10.1111/pcmr.12315 · Cited by 33

Tumor microenvironment conditions alter Akt and Na+/H+ exchanger NHE1 expression in endothelial cells more than hypoxia alone: implications for endothelial cell function in cancer

Pedersen, A. K., de Melo, J. M. L., Mørup, N., Tritsaris, K., & Pedersen, S. F. (2017) · BMC Cancer · doi:10.1186/s12885-017-3532-x · Cited by 34

CD133 positive U87 glioblastoma cells-derived exosomal microRNAs in hypoxia- versus normoxia-microenviroment

Zhang, G., Zhang, Y., Cheng, S., Wu, Z., Liu, F., & Zhang, J. (2017) · Journal of Neuro-Oncology · doi:10.1007/s11060-017-2566-x · Cited by 35

Structure‐Activity Relationship and Crystallographic Studies on 4‐Hydroxypyrimidine HIF Prolyl Hydroxylase Domain Inhibitors

Holt‐Martyn, J. P., Chowdhury, R., Tumber, A., Yeh, T., Abboud, M. I., Lippl, K., Lohans, C. T., Langley, G. W., Figg, W. D., McDonough, M. A., et al. (2019) · ChemMedChem · doi:10.1002/cmdc.201900557 · Cited by 33

Metal–organic framework tethering pH- and thermo-responsive polymer for ON–OFF controlled release of guest molecules

Nagata, S., Kokado, K., & Sada, K. (2019) · CrystEngComm · doi:10.1039/c9ce01731c · Cited by 33

Recent development of gene therapy for pancreatic cancer using non-viral nanovectors

Liu, Y., Wu, W., Wang, Y., Han, S., Yuan, Y., Huang, J., Shuai, X., & Peng, Z. M. (2021) · Biomaterials Science · doi:10.1039/d1bm00748c · Cited by 35

Cervical cancer-derived exosomal miR-663b promotes angiogenesis by inhibiting vinculin expression in vascular endothelial cells

You, X., Sun, W., Wang, Y., Liu, X., Wang, A., Liu, L., Han, S., Sun, Y., Zhang, J., Guo, L., et al. (2021) · Cancer Cell International · doi:10.1186/s12935-021-02379-9 · Cited by 34

Role of Hypoxia-inducible factor-1α and Survivin in colorectal carcinoma progression

Fan, L., Dong, W., Jiang, C., Qian, Q., & Yu, Q. (2008) · International Journal of Colorectal Disease · doi:10.1007/s00384-008-0511-3 · Cited by 33

Robust metabolic adaptation underlying tumor progression

Vizán, P., Mazurek, S., & Cascante, M. (2008) · Metabolomics · doi:10.1007/s11306-007-0101-3 · Cited by 35

ARDent about acetylation and deacetylation in hypoxia signalling

Bilton, R. L., Trottier, E., Pouysségur, J., & Brahimi-Horn, M. C. (2006) · Trends in Cell Biology · doi:10.1016/j.tcb.2006.10.002 · Cited by 34

Photoacid Generators for Biomedical Applications

Sun, T., Kang, L., Zhao, H., Zhao, Y., & Gu, Y. (2023) · Advanced Science · doi:10.1002/advs.202302875 · Cited by 34

Screening for possible miRNA–mRNA associations in a colon cancer cell line

Kanematsu, S., Tanimoto, K., Suzuki, Y., & Sugano, S. (2013) · Gene · doi:10.1016/j.gene.2013.08.005 · Cited by 32

Lactate transporters and vascular factors in HPV-induced squamous cell carcinoma of the uterine cervix

Pinheiro, C. M., Garcia, E. A., Morais-Santos, F., Scapulatempo‐Neto, C., da Costa, A. M., Steenbergen, R. D. M., Boccardo, E., Villa, L. L., Baltazar, F., & Longatto‐Filho, A. (2014) · BMC Cancer · doi:10.1186/1471-2407-14-751 · Cited by 32

Hypoxia activates the IGF-1 expression through STAT5b in human HepG2 cells

Joung, Y.-H., Lee, M. Y., Lim, E.-J., Kim, M., Hwang, T. S., Kim, S., Ye, S., Lee, J.-D., Park, T., Woo, Y.-S., et al. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.04.201 · Cited by 32

Insights into the therapeutic potential of hypoxia-inducible factor-1α small interfering RNA in malignant melanoma delivered via folate-decorated cationic liposomes

Zhang, X., Chen, Z., Zhang, T., & Wu, B. (2016) · International Journal of Nanomedicine · doi:10.2147/ijn.s101872 · Cited by 32

Autophagy and TrkC/NT-3 signaling joined forces boost the hypoxic glioblastoma cell survival

Jawhari, S., Bessette, B., Hombourger, S., Durand, K., Lacroix, A., Labrousse, F., Jauberteau, M., Ratinaud, M., & Verdier, M. (2017) · Carcinogenesis · doi:10.1093/carcin/bgx029 · Cited by 34

HIF-1α Promotes the Metastasis of Esophageal Squamous Cell Carcinoma by Targeting SP1

Hu, X., Lin, J., Jiang, M., He, X., Wang, K., Wang, W., Hu, C., Shen, Z., He, Z., Lin, H., et al. (2019) · Journal of Cancer · doi:10.7150/jca.35537 · Cited by 32

Hypoxia in Lung Cancer Management: A Translational Approach

Ancel, J., Perotin, J., Dewolf, M., Launois, C., Mulette, P., Nawrocki‐Raby, B., Dalstein, V., Gilles, C., Deslée, G., Polette, M., et al. (2021) · Cancers · doi:10.3390/cancers13143421 · Cited by 32

Photosubstitution in a trisheteroleptic ruthenium complex inhibits conjunctival melanoma growth in a zebrafish orthotopic xenograft model

Chen, Q., Cuello‐Garibo, J., Bretin, L., Zhang, L., Ramu, V., Aydar, Y., Batsiun, Y., Bronkhorst, S., Husiev, Y., Beztsinna, N., et al. (2022) · Chemical Science · doi:10.1039/d2sc01646j · Cited by 32

Pentachlorophenol exposure causes Warburg-like effects in zebrafish embryos at gastrulation stage

Xu, T., Zhao, J., Hu, P., Dong, Z., Li, J., Zhang, H., Yin, D., & Zhao, Q. (2014) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2014.03.004 · Cited by 32

Artemin is hypoxia responsive and promotes oncogenicity and increased tumor initiating capacity in hepatocellular carcinoma

Zhang, M., Zhang, W., Wu, Z., Liu, S., Sun, L., Zhong, Y., Zhang, X., Kong, X., Qian, P., Zhang, H., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.6572 · Cited by 31

Cancer cell migration and cancer drug screening in oxygen tension gradient chip

Nam, H., Funamoto, K., & Jeon, J. S. (2020) · Biomicrofluidics · doi:10.1063/5.0011216 · Cited by 34

Lactic acid in alternative polarization and function of macrophages in tumor microenvironment

Goswami, K. K., Banerjee, S., Bose, A., & Baral, R. (2022) · Human Immunology · doi:10.1016/j.humimm.2022.02.007 · Cited by 31

EXPRESSION OF CONCERN: Prolyl hydroxylase‐2 ( PHD2 ) exerts tumor‐suppressive activity in pancreatic cancer

Su, Y. Y., Loos, M., Giese, N., Metzen, E., Büchler, M. W., Frieß, H., Kornberg, A., & Büchler, P. (2011) · Cancer · doi:10.1002/cncr.26344 · Cited by 31

Expected clinical applications of circulating tumor cells in breast cancer

Park, Y. (2011) · World Journal of Clinical Oncology · doi:10.5306/wjco.v2.i8.303 · Cited by 31

Hypoxia Triggers Major Metabolic Changes in AML Cells without Altering Indomethacin-Induced TCA Cycle Deregulation

Lodi, A., Tiziani, S., Khanim, F. L., Drayson, M. T., Günther, U. L., Bunce, C. M., & Viant, M. R. (2010) · ACS Chemical Biology · doi:10.1021/cb900300j · Cited by 31

Spermine accelerates hypoxia-initiated cancer cell migration

Soda (2010) · International Journal of Oncology · doi:10.3892/ijo.2010.849 · Cited by 31

Macrophage migration inhibitory factor: a potential driver and biomarker for head and neck squamous cell carcinoma

Wang, S., Cen, X. B., Liang, X., & Tang, Y. (2016) · Oncotarget · doi:10.18632/oncotarget.12890 · Cited by 31

Hypoxia, a Targetable Culprit to Counter Pancreatic Cancer Resistance to Therapy

Khouzam, R. A., Lehn, J., Mayr, H., Clavien, P., Wallace, M. B., Ducreux, M. P., Limani, P., & Chouaïb, S. (2023) · Cancers · doi:10.3390/cancers15041235 · Cited by 33

Functional Imaging of Hypoxia: PET and MRI

Perez, R. C., Kim, D., Maxwell, A. W. P., & Camacho, J. C. (2023) · Cancers · doi:10.3390/cancers15133336 · Cited by 30

Isogambogenic acid induces apoptosis-independent autophagic cell death in human non-small-cell lung carcinoma cells

Yang, J., Zhou, Y., Cheng, X., Fan, Y., He, S., Li, S., Ye, H., Xie, C., Wu, W., Li, C., et al. (2015) · Scientific Reports · doi:10.1038/srep07697 · Cited by 30

Whole transcriptome RNA-seq analysis: tumorigenesis and metastasis of melanoma

Zhao, H., Li, Y., Wang, S., Yang, Y., Wang, J., Ruan, X., Yang, Y., Cai, K., Zhang, B., Cui, P., et al. (2014) · Gene · doi:10.1016/j.gene.2014.07.038 · Cited by 30

Kinome Sirna Screen Identifies SMG-1 as a Negative Regulator of Hypoxia-inducible Factor-1α in Hypoxia

Chen, R.-Q., Yang, Q., Chen, Y., Oliveira, V. A., Dalton, W. S., Fearns, C., & Lee, J. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.014316 · Cited by 30

Effect of hypoxia on tissue factor pathway inhibitor expression in breast cancer

Cui, X., Tinholt, M., Stavik, B., Dahm, A. E. A., Kanse, S. M., Jin, Y., Seidl, S., Sahlberg, K. K., Iversen, N., Skretting, G., et al. (2015) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.13206 · Cited by 31

Characterization of the expression of the pro-metastatic MenaINV isoform during breast tumor progression

Oudin, M. J., Hughes, S. K., Rohani, N., Moufarrej, M. N., Jones, J. G., Condeelis, J. S., Lauffenburger, D. A., & Gertler, F. B. (2015) · Clinical & Experimental Metastasis · doi:10.1007/s10585-015-9775-5 · Cited by 30

Impaired Neovascularization in Aging

Bonham, C. A., Kuehlmann, B. A., & Gurtner, G. C. (2019) · Advances in Wound Care · doi:10.1089/wound.2018.0912 · Cited by 31

Uniform Noting for International Application of the Tumor-Stroma Ratio as an Easy Diagnostic Tool: Protocol for a Multicenter Prospective Cohort Study

Smit, M. A., van Pelt, G. W., Roodvoets, A. G. H., Kranenbarg, E. M., Putter, H., Tollenaar, R. A. �. �., van Krieken, J. H., & Mesker, W. E. (2019) · JMIR Research Protocols · doi:10.2196/13464 · Cited by 30

Metformin Inhibits Epithelial-to-Mesenchymal Transition of Keloid Fibroblasts via the HIF-1α/PKM2 Signaling Pathway

Lei, R., Zhang, S., Wang, Y., Dai, S., Sun, J., & Zhu, C. (2019) · International Journal of Medical Sciences · doi:10.7150/ijms.32157 · Cited by 32

An intelligent persistent luminescence nanoplatform with high-efficiency O2 utilization for continuous hypoxic tumors treatment

Lin, P., Shi, J., Ming, L., Sheng, Y., Song, L., Hong, M., & Zhang, Y. (2022) · Chemical Engineering Journal · doi:10.1016/j.cej.2022.135638 · Cited by 30

Nonlinear Modeling and Simulation of Tumor Growth

Vittorio Cristini, C., Frieboes, H. B., Li, X., Lowengrub, J. S., Macklin, P., Sanga, S., Wise, S. M., & Zheng, X. (2008) · Modeling and simulation in science, engineering & technology · doi:10.1007/978-0-8176-4713-1_6 · Cited by 31

Hypoxia Negatively Regulates Antimetastatic PEDF in Melanoma Cells by a Hypoxia Inducible Factor-Independent, Autophagy Dependent Mechanism

Fernández‐Barral, A., Orgaz, J. L., Gómez, V., del Peso, L., Calzada, M. J., & Jiménez, B. (2012) · PLoS ONE · doi:10.1371/journal.pone.0032989 · Cited by 30

Organellar (Na+, K+)/H+ exchanger NHE7 regulates cell adhesion, invasion and anchorage-independent growth of breast cancer MDA-MB-231 cells

Numata, M. (2011) · Oncology Reports · doi:10.3892/or.2011.1542 · Cited by 29

Modulation of cell surface density of carbonic anhydrase IX by shedding of the ectodomain and endocytosis

Zaťovičová, M., & Pastoreková, S. (2013) · Acta Virologica · doi:10.4149/av_2013_02_257 · Cited by 30

Serum total IgE and specific IgE to Dermatophagoides pteronyssinus, but not eosinophil cationic protein, are more likely to be elevated in elderly asthmatic patients.

King, M. J., Bukantz, S. C., Phillips, S. E., Mohapatra, S. S., Tamulis, T., & Lockey, R. F. (2004) · PubMed · Cited by 30

Identification of carbonic anhydrase 9 as a contributor to pingyangmycin‐induced drug resistance in human tongue cancer cells

Zheng, G., Zhou, M., Ou, X.-R., Peng, B., Yu, Y., Kong, F., Ouyang, Y., & He, Z. (2010) · FEBS Journal · doi:10.1111/j.1742-4658.2010.07836.x · Cited by 29

Components of cancer metabolism and therapeutic interventions

Singleterry, J., Sreedhar, A., & Zhao, Y. (2014) · Mitochondrion · doi:10.1016/j.mito.2014.05.010 · Cited by 28

Diosmin induce apoptosis through modulation of STAT-3 signaling in 7,12 dimethylbenz(a)anthracene induced harmster buccal pouch carcinogenesis

Rajasekar, M., Kathiresan, S., & Sivakumar, K. (2016) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2016.08.019 · Cited by 29

Caveolin-3 plays a critical role in autophagy after ischemia-reperfusion

Kassan, A., Pham, U., Nguyen, Q., Reichelt, M. E., Cho, E., Patel, P. M., Roth, D. M., Head, B. P., & Patel, H. H. (2016) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00147.2016 · Cited by 27

Structural characterizations of human periostin dimerization and cysteinylation

Liu, J., Zhang, J., Xu, F., Lin, Z., Li, Z., & Liu, H. (2018) · FEBS Letters · doi:10.1002/1873-3468.13091 · Cited by 29

HIF1α-dependent upregulation of ATAD2 promotes proliferation and migration of stomach cancer cells in response to hypoxia

Nayak, A., Roy, A. D., Rout, N., Singh, S. P., Bhattacharyya, A., & Roychowdhury, A. (2020) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.12.130 · Cited by 29

Modulation of the Pharmacokinetics of a Radioligand Targeting Carbonic Anhydrase-IX with Albumin-Binding Moieties

Iikuni, S., Okada, Y., Shimizu, Y., Watanabe, H., & Ono, M. (2021) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.0c00953 · Cited by 29

Hypoxia disrupt tight junctions and promote metastasis of oral squamous cell carcinoma via loss of par3

Kim, S., Park, S., Moon, E.-H., Kim, G. J., & Choi, J. (2023) · Cancer Cell International · doi:10.1186/s12935-023-02924-8 · Cited by 30

Akt signaling is required for glioblastoma maintenance in vivo.

Robinson, J. P., VanBrocklin, M. W., McKinney, A. J., Gach, H. M., & Holmen, S. L. (2011) · Europe PMC (PubMed Central) · Cited by 29

Identification of the Hypoxia-inducible Factor 2α Nuclear Interactome in Melanoma Cells Reveals Master Proteins Involved in Melanoma Development

Steunou, A., Ducoux‐Petit, M., Lazar, I., Monsarrat, B., Érard, M., Muller, C., Clottes, E., Burlet‐Schiltz, O., & Nieto, L. (2012) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m112.020727 · Cited by 35

Hypoxia promotes migration/invasion and glycolysis in head and neck squamous cell carcinoma via an HIF-1α-MTDH loop

Zhu, G., Peng, F., Gong, W. J., She, L., Wei, M., Tan, H., Chen, C., Zhang, D., Guo, L., Huang, D., et al. (2017) · Oncology Reports · doi:10.3892/or.2017.5949 · Cited by 30

An explorative analysis of the prognostic value of lactate dehydrogenase for survival and the chemotherapeutic response in patients with advanced triple-negative breast cancer

Jia, Z., Zhang, J., Wang, Z., Wang, B., Wang, L., Cao, J., Tao, Z., & Hu, X. (2018) · Oncotarget · doi:10.18632/oncotarget.24246 · Cited by 29

Carbonic anhydrase IX is a prognostic biomarker in glioblastoma multiforme

Çetin, B., Gönül, İ. I., Gümüşay, Ö., Bilgetekin, İ., Algın, E., Özet, A., & Üner, A. (2018) · Neuropathology · doi:10.1111/neup.12485 · Cited by 29

Lysyl oxidase (LOX) and hypoxia-induced metastases

Mingo-Sion, A. M., & Figg, W. D. (2006) · Cancer Biology & Therapy · doi:10.4161/cbt.5.8.3230 · Cited by 29

Carbonic anhydrase IX

Švastová, E., & Pastoreková, S. (2013) · Cell Adhesion & Migration · doi:10.4161/cam.23257 · Cited by 29

Metabolic consequences of treatment with AKT inhibitor perifosine in breast cancer cells

Su, J. S., Woods, S. M., & Ronen, S. M. (2011) · NMR in Biomedicine · doi:10.1002/nbm.1764 · Cited by 28

Gankyrin is essential for hypoxia enhanced metastatic potential in breast cancer cells

Gao, L., Xie, H., Dong, L., Zou, J., Fu, J., GAO, X., Ou, L., Xiang, S., & Song, H. (2013) · Molecular Medicine Reports · doi:10.3892/mmr.2013.1860 · Cited by 28

Protein kinase D2: a versatile player in cancer biology

Azoitei, N., Cobbaut, M., Becher, A., Lint, J. V., & Seufferlein, T. T. W. (2017) · Oncogene · doi:10.1038/s41388-017-0052-8 · Cited by 28

Mechanochemical generation of singlet oxygen

Türksoy, A., Yıldız, D., Aydonat, S., Bedük, T., Canyurt, M., Baytekin, B., & Akkaya, E. U. (2020) · RSC Advances · doi:10.1039/d0ra00831a · Cited by 28

Transcriptomic analysis reveals dynamic molecular changes in skin induced by mechanical forces secondary to tissue expansion

Ledwon, J. K., Kelsey, L. J., Vaca, E. E., & Gosain, A. K. (2020) · Scientific Reports · doi:10.1038/s41598-020-71823-z · Cited by 28

Hypoxic stress suppresses lung tumor-secreted exosomal miR101 to activate macrophages and induce inflammation

Li, J., Xu, P., Wu, D., Guan, M.-J., Weng, X., Lu, Y., Zeng, Y., & Chen, R. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-04030-x · Cited by 28

Overcoming Radiation Resistance in Gliomas by Targeting Metabolism and DNA Repair Pathways

Meng, W., Palmer, J. D., Siedow, M. R., Haque, S. J., & Chakravarti, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23042246 · Cited by 34

Overcoming cancer-associated fibroblast-induced immunosuppression by anti-interleukin-6 receptor antibody

Nishiwaki, N., Noma, K., Ohara, T., Kunitomo, T., Kawasaki, K., Akai, M., Kobayashi, T., Narusaka, T., Kashima, H., Sato, H., et al. (2023) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-023-03378-7 · Cited by 28

Supramolecular nanoparticles constructed by orthogonal assembly of pillar[5]arene-cyclodextrin dimacrocycle for chemo-photodynamic combination therapy

Yin, Y., Sun, P., Dong, H., Chen, Y., Chen, S., & Wang, L. (2023) · Chinese Chemical Letters · doi:10.1016/j.cclet.2023.108594 · Cited by 28

Oxygen Sensing: A Common Crossroad in Cancer and Neurodegeneration

Quaegebeur, A., & Carmeliet, P. (2010) · Current topics in microbiology and immunology · doi:10.1007/82_2010_83 · Cited by 27

Arsenic Trioxide Inhibits CXCR4-Mediated Metastasis by Interfering miR-520h/PP2A/NF-κB Signaling in Cervical Cancer

Chang, Y.-W., Chen, M.-W., Chiu, C., Hong, C., Cheng, C.-C., Hsiao, M., Chen, C., Wei, L., & Su, J.-L. (2014) · Annals of Surgical Oncology · doi:10.1245/s10434-014-3812-5 · Cited by 28

Hypoxia-inducible factor-1: A possible link between inhalational anesthetics and tumor progression?

Zhao, H., Iwasaki, M., Yang, J., Savage, S., & Ma, D. (2014) · Acta anaesthesiologica Taiwanica · doi:10.1016/j.aat.2014.05.008 · Cited by 28

The hypoxia-mimetic agent CoCl2 induces chemotherapy resistance in LOVO colorectal cancer cells

YANG, G., XU, S., PENG, L., Li, H., Zhao, Y., & Hu, Y. (2016) · Molecular Medicine Reports · doi:10.3892/mmr.2016.4836 · Cited by 29

OTUB2 silencing promotes ovarian cancer via mitochondrial metabolic reprogramming and can be synthetically targeted by CA9 inhibition

Nan, Y., Wu, X., Luo, Q., Chang, W., Zhao, P., Zhang, L., & Liu, Z. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2315348121 · Cited by 27

Benzothiazole derivatives in the design of antitumor agents

Paoletti, N., & Supuran, C. T. (2024) · Archiv der Pharmazie · doi:10.1002/ardp.202400259 · Cited by 27

Potential signaling pathway involved in sphingosine-1-phosphate-induced epithelial-mesenchymal transition in cancer

Zeng, Y., Yao, X., Yan, Z., Liu, J., & Liu, X. (2016) · Oncology Letters · doi:10.3892/ol.2016.4661 · Cited by 27

The role of the hypoxia-inducible factor in tumor metabolism growth and invasion.

Brahimi‐Horn, C., & Pouysségur, J. (2006) · PubMed · Cited by 154

Hypoxia and energetic tumour metabolism

Brahimi-Horn, M. C., Bellot, G. L., & Pouysségur, J. (2010) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2010.10.006 · Cited by 247

Hypoxia in cancer cell metabolism and pH regulation

Brahimi-Horn, M. C., & Pouysségur, J. (2007) · Essays in Biochemistry · doi:10.1042/bse0430165 · Cited by 113

The role of hypoxic signalling in metastasis: towards translating knowledge of basic biology into novel anti-tumour strategies

Henríquez, J. A., Sleeman, J. P., & Garvalov, B. K. (2018) · Clinical & Experimental Metastasis · doi:10.1007/s10585-018-9930-x · Cited by 37

Tumour hypoxia induces a metabolic shift causing acidosis: a common feature in cancer

Chiche, J., Brahimi-Horn, M. C., & Pouysségur, J. (2010) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2009.00994.x · Cited by 700