Cited by 1,676Cancer, Hypoxia, and MetabolismAngiogenesis and VEGF in CancerFerroptosis and cancer prognosis

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Hypoxia signalling in cancer and approaches to enforce tumour regression

Pouysségur, Jacques, Dayan, Frédéric, Mazure, Nathalie M.·2006·Nature

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Abstract

Tumour cells emerge as a result of genetic alteration of signal circuitries promoting cell growth and survival, whereas their expansion relies on nutrient supply. Oxygen limitation is central in controlling neovascularization, glucose metabolism, survival and tumour spread. This pleiotropic action is orchestrated by hypoxia-inducible factor (HIF), which is a master transcriptional factor in nutrient stress signalling. Understanding the role of HIF in intracellular pH (pH(i)) regulation, metabolism, cell invasion, autophagy and cell death is crucial for developing novel anticancer therapies. There are new approaches to enforce necrotic cell death and tumour regression by targeting tumour metabolism and pH(i)-control systems.

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Authors: Pouysségur, J., Dayan, F., & Mazure, N. M.
Affiliations: Centre National de la Recherche Scientifique (FR)
Corresponding author: Pouysségur, Jacques
ORCID: Pouysségur, Jacques
Mazure, Nathalie M.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2006-05-24
Volume: 441
Issue: 7092
Pages: 437-443
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature04871
OpenAlex: W2082483448
Semantic Scholar: 5bbdcf74ee4cdf263a532b6dbae0b8dd5efb9722
Cited by: 1,676
References: 104
Citations by year: 2026: 19 · 2025: 39 · 2024: 48 · 2023: 75 · 2022: 85 · 2021: 97 · 2020: 87 · 2019: 77 · 2018: 81 · 2017: 68 · 2016: 85 · 2015: 80 · 2014: 103 · 2013: 104 · 2012: 89
FWCI: 6.91
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Funders: Ligue Contre le Cancer
Centre National de la Recherche Scientifique
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Ferroptosis and cancer prognosis
Keywords: hypoxia signaling, hypoxia-inducible factor, tumor hypoxia, tumor regression, cancer metabolism, intracellular pH regulation, tumor angiogenesis, glucose metabolism, necrosis, autophagy, cell invasion, cancer therapy, tumor oxygenation
MeSH terms: Animals, Humans, Neoplasms, Neovascularization, Pathologic, Oxygen, Protein Kinases, Signal Transduction, Cell Hypoxia, TOR Serine-Threonine Kinases

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Hypoxia signalling in cancer and approaches to enforce tumour regression

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