Cited by 1,676Cancer, Hypoxia, and MetabolismAngiogenesis and VEGF in CancerFerroptosis and cancer prognosis

The DOI matches its Crossref record; 103 of the 104 references it cites were found in a registry or an index.

Hypoxia signalling in cancer and approaches to enforce tumour regression

Pouysségur, Jacques, Dayan, Frédéric, Mazure, Nathalie M.·2006·Nature

Open this paper in CoChat — free account

Abstract

Tumour cells emerge as a result of genetic alteration of signal circuitries promoting cell growth and survival, whereas their expansion relies on nutrient supply. Oxygen limitation is central in controlling neovascularization, glucose metabolism, survival and tumour spread. This pleiotropic action is orchestrated by hypoxia-inducible factor (HIF), which is a master transcriptional factor in nutrient stress signalling. Understanding the role of HIF in intracellular pH (pH(i)) regulation, metabolism, cell invasion, autophagy and cell death is crucial for developing novel anticancer therapies. There are new approaches to enforce necrotic cell death and tumour regression by targeting tumour metabolism and pH(i)-control systems.

Integrity signals

Registry

Crossref · 10.1038/nature04871

Cites

103 of 103 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

1 retracted

Lysyl oxidase is essential for hypoxia-induced metastasis
Erler, J. T., Bennewith, K. L., Nicolau, M., Dornhöfer, N., Kong, C., Le, Q.-T., Chi, J.-T. A., Jeffrey, S. S., & Giaccia, A. J. (2006) · Nature · doi:10.1038/nature04695 · Cited by 1,309
Retracted
The biology of VEGF and its receptors
Ferrara, N., Gerber, H.-P., & LeCouter, J. (2003) · Nature Medicine · doi:10.1038/nm0603-669 · Cited by 9,591
Targeting HIF-1 for cancer therapy
Semenza, G. L. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1187 · Cited by 6,717
Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O 2 -Regulated Prolyl Hydroxylation
Jaakkola, P., Mole, D. R., Tian, Y.-M., Wilson, M. I., Gielbert, J., Gaskell, S. J., Kriegsheim, A. V., Hebestreit, H. F., Mukherji, M., Schofield, C. J., et al. (2001) · Science · doi:10.1126/science.1059796 · Cited by 5,535
Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene
Ferrara, N., Carver-Moore, K., Chen, H., Dowd, M., Lu, L., O’Shea, K. S., Powell-Braxton, L., Hillan, K. J., & Moore, M. W. (1996) · Nature · doi:10.1038/380439a0 · Cited by 3,661
Angiopoietin-2, a Natural Antagonist for Tie2 That Disrupts in vivo Angiogenesis
Maisonpierre, P. C., Suri, C., Jones, P. F., Bartunkova, S., Wiegand, S. J., Radziejewski, C., Compton, D., McClain, J., Aldrich, T. H., Papadopoulos, N., et al. (1997) · Science · doi:10.1126/science.277.5322.55 · Cited by 3,570
C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation
Epstein, A. C. R., Gleadle, J. M., McNeill, L. A., Hewitson, K. S., O'Rourke, J., Mole, D. R., Mukherji, M., Metzen, E., Wilson, M. I., Dhanda, A., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00507-4 · Cited by 3,333
VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia
Gerhardt, H., Golding, M., Fruttiger, M., Ruhrberg, C., Lundkvist, A., Abramsson, A., Jeltsch, M., Mitchell, C., Alitalo, K., Shima, D., et al. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200302047 · Cited by 2,894
AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism
Kahn, B. B., Alquier, T., Carling, D., & Hardie, D. G. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2004.12.003 · Cited by 2,799
Angiogenesis as a therapeutic target
Ferrara, N., & Kerbel, R. S. (2005) · Nature · doi:10.1038/nature04483 · Cited by 2,653

Show all 104 references

Sorted by citations

Items 101–200 of 1,002

Label-free oxygen-metabolic photoacoustic microscopy in vivo
Yao, J., Maslov, K., Zhang, Y. S., Younan Xia, A., & Wang, L. V. (2011) · Journal of Biomedical Optics · doi:10.1117/1.3594786 · Cited by 332
PHD2 Mutation and Congenital Erythrocytosis with Paraganglioma
Ladroue, C., Carcenac, R., Leporrier, M., Gad, S., Le Hello, C., Galateau-Salle, F., Feunteun, J., Pouysségur, J., Richard, S., & Gardie, B. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0806277 · Cited by 323
Self-citation
RSUME, a Small RWD-Containing Protein, Enhances SUMO Conjugation and Stabilizes HIF-1α during Hypoxia
Carbia-Nagashima, A., Gerez, J., Perez-Castro, C., Paez-Pereda, M., Silberstein, S., Stalla, G. K., Holsboer, F., & Arzt, E. (2007) · Cell · doi:10.1016/j.cell.2007.07.044 · Cited by 318
Metastasis: cancer cell’s escape from oxidative stress
Pani, G., Galeotti, T., & Chiarugi, P. (2010) · Cancer and Metastasis Reviews · doi:10.1007/s10555-010-9225-4 · Cited by 328
Hypoxia regulates global membrane protein endocytosis through caveolin-1 in cancer cells
Bourseau-Guilmain, E., Menard, J. A., Lindqvist, E., Chandran, V. I., Christianson, H. C., Cerezo-Magaña, M., Lidfeldt, J., Marko‐Varga, G., Welinder, C., & Belting, M. (2016) · Nature Communications · doi:10.1038/ncomms11371 · Cited by 308
Heme Oxygenase-1 and Carbon Monoxide in Vascular Pathobiology
Dulak, J., Deshane, J. S., Józkowicz, A., & Agarwal, A. (2008) · Circulation · doi:10.1161/circulationaha.107.698316 · Cited by 306
Biology of glucose metabolization in cancer cells
Fadaka, A. O., Ajiboye, B. O., Ojo, O. A., Adewale, O. B., Olayide, I., & Emuowhochere, R. (2017) · Journal of Oncological Sciences · doi:10.1016/j.jons.2017.06.002 · Cited by 309
Hypoxia, cancer metabolism and the therapeutic benefit of targeting lactate/H(+) symporters
Marchiq, I., & Pouysségur, J. (2016) · Journal of Molecular Medicine · doi:10.1007/s00109-015-1307-x · Cited by 300
Self-citation
Hypoxia-driven pathways in bone development, regeneration and disease
Maes, C., Carmeliet, G., & Schipani, E. (2012) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2012.36 · Cited by 307
Mitochondrial gateways to cancer
Galluzzi, L., Morselli, E., Kepp, O., Vitale, I., Rigoni, A., Vacchelli, E., Michaud, M., Zischka, H., Castedo, M., & Kroemer, G. (2009) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2009.08.002 · Cited by 303
Hypoxia signalling controls metabolic demand
Brahimi-Horn, M. C., Chiche, J., & Pouysségur, J. (2007) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2007.02.003 · Cited by 298
Self-citation
Hypoxia signaling pathways in cancer metabolism: the importance of co-selecting interconnected physiological pathways
Masson, N., & Ratcliffe, P. J. (2014) · Cancer & Metabolism · doi:10.1186/2049-3002-2-3 · Cited by 305
The role of vascular endothelial growth factor in ossification
Yang, Y., Tan, Y., Wong, R., Wenden, A., Zhang, L.-K., & Rabie, A. B. M. (2012) · International Journal of Oral Science · doi:10.1038/ijos.2012.33 · Cited by 304
Extracellular vesicles: mediators of intercellular communication in tissue injury and disease
Sánchez, G. B., Bunn, K. E., Pua, H. H., & Rafat, M. (2021) · Cell Communication and Signaling · doi:10.1186/s12964-021-00787-y · Cited by 297
Oxygen Sensors at the Crossroad of Metabolism
Aragonés, J., Fraisl, P., Baes, M. I., & Carmeliet, P. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2008.10.001 · Cited by 293
Hypoxia induced EMT: A review on the mechanism of tumor progression and metastasis in OSCC
Joseph, J. P., Harishankar, M. K., Pillai, A. A., & Devi, A. (2018) · Oral Oncology · doi:10.1016/j.oraloncology.2018.03.004 · Cited by 282
RNA-Binding Proteins HuR and PTB Promote the Translation of Hypoxia-Inducible Factor 1α
Galbán, S., Kuwano, Y., Pullmann, R., Martindale, J. L., Kim, H. H., Lal, A., Abdelmohsen, K., Yang, X., Dang, Y., Liu, J. O., et al. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.00973-07 · Cited by 288
Overcoming chemotherapy drug resistance by targeting inhibitors of apoptosis proteins (IAPs)
Rathore, R., McCallum, J. E., Varghese, E., Florea, A.-M., & Büsselberg, D. (2017) · APOPTOSIS · doi:10.1007/s10495-017-1375-1 · Cited by 288
Tailoring photosensitive ROS for advanced photodynamic therapy
Sai, D. L., Lee, J., Nguyen, D. L., & Kim, Y. (2021) · Experimental & Molecular Medicine · doi:10.1038/s12276-021-00599-7 · Cited by 287
Advances in Application of Azobenzene as a Trigger in Biomedicine: Molecular Design and Spontaneous Assembly
Cheng, H., Zhang, S., Qi, J., Liang, X., & Yoon, J. (2021) · Advanced Materials · doi:10.1002/adma.202007290 · Cited by 286
A Bifunctional Photosensitizer for Enhanced Fractional Photodynamic Therapy: Singlet Oxygen Generation in the Presence and Absence of Light
Turan, I. S., Yıldız, D., Türksoy, A., Günaydın, G., & Akkaya, E. U. (2016) · Angewandte Chemie International Edition · doi:10.1002/anie.201511345 · Cited by 276
Mitophagy and cancer
Chourasia, A. H., Boland, M. L., & Macleod, K. F. (2015) · Cancer & Metabolism · doi:10.1186/s40170-015-0130-8 · Cited by 284
The mechanisms by which polyamines accelerate tumor spread
Soda, K. (2011) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/1756-9966-30-95 · Cited by 276
Reciprocal influence of the p53 and the hypoxic pathways
Sermeus, A., & Michiels, C. (2011) · Cell Death and Disease · doi:10.1038/cddis.2011.48 · Cited by 278
Hypoxia regulates Hippo signalling through the SIAH2 ubiquitin E3 ligase
Ma, B., Chen, Y., Chen, L., Cheng, H., Mu, C., Li, J., Gao, R., Zhou, C., Cao, L., Liu, J., et al. (2015) · Nature Cell Biology · doi:10.1038/ncb3073 · Cited by 266
A nanotherapeutic strategy to overcome chemotherapeutic resistance of cancer stem-like cells
Shen, S., Xu, X., Lin, S., Zhang, Y., Liu, H., Zhang, C., & Mo, R. (2021) · Nature Nanotechnology · doi:10.1038/s41565-020-00793-0 · Cited by 274
Pyruvate dehydrogenase kinase regulatory mechanisms and inhibition in treating diabetes, heart ischemia, and cancer
Roche, T. E., & Hiromasa, Y. (2007) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-007-6380-z · Cited by 265
Tumor Angiogenic and Hypoxic Profiles Predict Radiographic Response and Survival in Malignant Astrocytoma Patients Treated With Bevacizumab and Irinotecan
Sathornsumetee, S., Cao, Y., Marcello, J. E., Herndon, J. E., McLendon, R. E., Desjardins, A., Friedman, H. S., Dewhirst, M. W., Vredenburgh, J. J., & Rich, J. N. (2008) · Journal of Clinical Oncology · doi:10.1200/jco.2007.13.3652 · Cited by 262
Randomized Phase II Study Comparing Two Schedules of Everolimus in Patients With Recurrent/Metastatic Breast Cancer: NCIC Clinical Trials Group IND.163
Ellard, S. L., Clemons, M. J., Gelmon, K. A., Norris, B. D., Kennecke, H. F., Chia, S., Pritchard, K. I., Eisen, A. F., Vandenberg, T. A., Taylor, M., et al. (2009) · Journal of Clinical Oncology · doi:10.1200/jco.2008.21.3033 · Cited by 259
Carbonic anhydrase inhibitors as emerging agents for the treatment and imaging of hypoxic tumors
Supuran, C. T. (2018) · Expert Opinion on Investigational Drugs · doi:10.1080/13543784.2018.1548608 · Cited by 262
The multiple roles of amphiregulin in human cancer
Busser, B., Sancey, L., Brambilla, E. M., Coll, J., & Hurbin, A. (2011) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2011.05.003 · Cited by 261
Three-gene prognostic classifier for early-stage non small-cell lung cancer
Lau, S. K., Boutros, P. C., Pintilie, M., Blackhall, F. H., Zhu, C.-Q., Strumpf, D., Johnston, M. R., Darling, G., Keshavjee, S., Waddell, T. K., et al. (2007) · Journal of Clinical Oncology · doi:10.1200/jco.2007.12.0352 · Cited by 255
The Lysyl Oxidases LOX and LOXL2 Are Necessary and Sufficient to Repress E-cadherin in Hypoxia
Schietke, R. E., Warnecke, C., Wacker, I., Schödel, J., Mole, D. R., Câmpean, V., Amann, K., Goppelt‐Struebe, M., Behrens, J., Eckardt, K., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.042424 · Cited by 266
Dynamic Change of Chromatin Conformation in Response to Hypoxia Enhances the Expression of GLUT3 (SLC2A3) by Cooperative Interaction of Hypoxia-Inducible Factor 1 and KDM3A
Mimura, I., Nangaku, M., Kanki, Y., Tsutsumi, S., Inoue, T., Kohro, T., Yamamoto, S., Fujita, T., Shimamura, T., Suehiro, J.-I., et al. (2012) · Molecular and Cellular Biology · doi:10.1128/mcb.06643-11 · Cited by 251
New frontiers in immune checkpoint B7-H3 (CD276) research and drug development
Getu, A. A., Tigabu, A., Zhou, M., Lu, J., Fodstad, Ø., & Tan, M. (2023) · Molecular Cancer · doi:10.1186/s12943-023-01751-9 · Cited by 260
Co-delivery of HIF1α siRNA and gemcitabine via biocompatible lipid-polymer hybrid nanoparticles for effective treatment of pancreatic cancer
Zhao, X. L., Li, F., Li, Y., Wang, H., Ren, H., Chen, J., Nie, G., & Hao, J. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2014.12.028 · Cited by 249
Mitophagy in tumorigenesis and metastasis
Poole, L. P., & Macleod, K. F. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-021-03774-1 · Cited by 257
Reactive oxygen species stabilize hypoxia-inducible factor-1 alpha protein and stimulate transcriptional activity via AMP-activated protein kinase in DU145 human prostate cancer cells
Jung, S., Yang, W. K., Kim, J., Kim, H. S., Kim, E. J., Yun, H., Park, H., Kim, S. S., Choe, W., Kang, I., et al. (2008) · Carcinogenesis · doi:10.1093/carcin/bgn032 · Cited by 257
A RNA antagonist of hypoxia-inducible factor-1α, EZN-2968, inhibits tumor cell growth
Greenberger, L. M., Horak, I. D., Filpula, D., Sapra, P., Westergaard, M., Frydenlund, H. F., Albæk, C., Schrøder, H., & Ørum, H. (2008) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-08-0510 · Cited by 245
Glycolysis, tumor metabolism, cancer growth and dissemination. A new pH-based etiopathogenic perspective and therapeutic approach to an old cancer question
Alfarouk, K. O., Verduzco, D., Rauch, C., Muddathir, A. K., Bashir, A. H. H., Elhassan, G. O., Ibrahim, M. E., Orozco, J. D. P., Cardone, R. A., Reshkin, S. J., et al. (2014) · Oncoscience · doi:10.18632/oncoscience.109 · Cited by 255
Tumor stroma: a complexity dictated by the hypoxic tumor microenvironment
Casazza, A., Conza, G. D., Wenes, M., Finisguerra, V., Deschoemaeker, S., & Mazzone, M. (2013) · Oncogene · doi:10.1038/onc.2013.121 · Cited by 254
Advances in nanomedicine for cancer starvation therapy
Yu, S., Chen, Z., Zeng, X., Chen, X., & Gu, Z. (2019) · Theranostics · doi:10.7150/thno.38261 · Cited by 241
Epithelial-to-mesenchymal transition: What is the impact on breast cancer stem cells and drug resistance
Mallini, P., Lennard, T. W. J., Kirby, J. A., & Meeson, A. P. (2013) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2013.09.008 · Cited by 247
Carbonic Anhydrase IX Promotes Tumor Growth and Necrosis In Vivo and Inhibition Enhances Anti-VEGF Therapy
McIntyre, A., Patiar, S., Wigfield, S., Li, J.-L., Ledaki, I., Turley, H., Leek, R., Snell, C., Gatter, K., Sly, W. S., et al. (2012) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-11-1877 · Cited by 239
Physiologic Oxygen Concentration Enhances the Stem-Like Properties of CD133+ Human Glioblastoma Cells In vitro
McCord, A. M., Jamal, M., Shankavarum, U. T., Lang, F. F., Camphausen, K. A., & Tofilon, P. J. (2009) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-08-0360 · Cited by 239
Leptin signaling in breast cancer: An overview
Cirillo, D., Rachiglio, A. M., Montagna, R. L., Giordano, A., & Normanno, N. (2008) · Journal of Cellular Biochemistry · doi:10.1002/jcb.21911 · Cited by 240
Cellular Functions of Tissue Transglutaminase
Nurminskaya, M. V., & Belkin, A. M. (2012) · International review of cytology · doi:10.1016/b978-0-12-394305-7.00001-x · Cited by 246
RETRACTED ARTICLE: Yes-associated protein (YAP) binds to HIF-1α and sustains HIF-1α protein stability to promote hepatocellular carcinoma cell glycolysis under hypoxic stress
Zhang, X., Li, Y., Ma, Y., Yang, L., Wang, T., Meng, X., Zong, Z., Sun, X., Hua, X., & Li, H. (2018) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-018-0892-2 · Cited by 240
Retracted
Carbonic Anhydrase Inhibition and the Management of Hypoxic Tumors
Supuran, C. T. (2017) · Metabolites · doi:10.3390/metabo7030048 · Cited by 234
New insights into the physiological role of carbonic anhydrase IX in tumour pH regulation
Swietach, P., Hulı́ková, A., Vaughan‐Jones, R. D., & Harris, A. L. (2010) · Oncogene · doi:10.1038/onc.2010.455 · Cited by 240
Nasopharyngeal carcinoma ecology theory: cancer as multidimensional spatiotemporal “unity of ecology and evolution” pathological ecosystem
Luo, W. (2023) · Theranostics · doi:10.7150/thno.82690 · Cited by 242
Hypoxia-Inducible Factor as an Angiogenic Master Switch
Hashimoto, T., & Shibasaki, F. (2015) · Frontiers in Pediatrics · doi:10.3389/fped.2015.00033 · Cited by 242
Hypoxia-triggered single molecule probe for high-contrast NIR II/PA tumor imaging and robust photothermal therapy
Meng, X., Zhang, J., Sun, Z., Zhou, L., Deng, G., Li, S., Li, W., Gong, P., & Cai, L. (2018) · Theranostics · doi:10.7150/thno.26607 · Cited by 231
Inorganic Biomaterials for Regenerative Medicine
Brokesh, A. M., & Gaharwar, A. K. (2020) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.9b17801 · Cited by 233
The anti-cancer drug lenalidomide inhibits angiogenesis and metastasis via multiple inhibitory effects on endothelial cell function in normoxic and hypoxic conditions
Lu, L., Payvandi, F., Wu, L., Zhang, L., HARIRI, R. J., Man, H., Chen, R. S., Muller, G. W., Hughes, C. C. W., Stirling, D., et al. (2008) · Microvascular Research · doi:10.1016/j.mvr.2008.08.003 · Cited by 228
Hypoxia and energetic tumour metabolism
Brahimi-Horn, M. C., Bellot, G. L., & Pouysségur, J. (2010) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2010.10.006 · Cited by 247
Self-citation
HIF at a glance
Brahimi-Horn, M. C., & Pouysségur, J. (2009) · Journal of Cell Science · doi:10.1242/jcs.035022 · Cited by 236
Self-citation
Cardamonin inhibits breast cancer growth by repressing HIF-1α-dependent metabolic reprogramming
Jin, J., Qiu, S., Wang, P., Liang, X., Huang, F., Wu, H., Zhang, B., Zhang, W., Tian, X.-H., Xu, R., et al. (2019) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-019-1351-4 · Cited by 226
Cancer Cell MetabolismPreprint
Cairns, R. A., Harris, I. S., McCracken, S. A., & Mak, T. W. (2011) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2011.76.012856 · Cited by 229
Efficient NIR-II Type-I AIE Photosensitizer for Mitochondria-Targeted Photodynamic Therapy through Synergistic Apoptosis–Ferroptosis
Zhuang, J., Wang, B., Chen, H., Zhang, K., Li, N., Zhao, N., & Tang, B. Z. (2023) · ACS Nano · doi:10.1021/acsnano.2c12319 · Cited by 226
Taking advantage of tumor cell adaptations to hypoxia for developing new tumor markers and treatment strategies
Ebbesen, P., Pettersen, E. O., Gorr, T. A., Jobst, G., Williams, K. J., Kieninger, J., Wenger, R. H., Pastoreková, S., Dubois, L. J., Lambin, P., et al. (2009) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.1080/14756360902784425 · Cited by 221
Hypoxia-induced Jagged2 promotes breast cancer metastasis and self-renewal of cancer stem-like cells
Xing, F., Okuda, H., Watabe, M., Kobayashi, A., Pai, S., Liu, W., Pandey, P., Fukuda, K., Hirota, S., Sugai, T., et al. (2011) · Oncogene · doi:10.1038/onc.2011.122 · Cited by 219
Carbonic anhydrase IX: Biochemical and crystallographic characterization of a novel antitumor target
Simone, G. D., & Supuran, C. T. (2009) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2009.07.027 · Cited by 218
DJ-1/PARK7 is an important mediator of hypoxia-induced cellular responses
Vasseur, S., Afzal, S., Tardivel‐Lacombe, J., Park, D. S., Iovanna, J., & Mak, T. W. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0812745106 · Cited by 217
Lysyl Oxidase Mediates Hypoxic Control of Metastasis
Erler, J. T., & Giaccia, A. J. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-3197 · Cited by 214
Hypoxia and hepatocellular carcinoma: The therapeutic target for hepatocellular carcinoma
Wu, X., Xie, G. R., & Chen, D. (2007) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2007.04997.x · Cited by 213
RETRACTED: Monodispersed Copper(I)‐Based Nano Metal–Organic Framework as a Biodegradable Drug Carrier with Enhanced Photodynamic Therapy Efficacy
Cai, X., Xie, Z., Ding, B., Shao, S., Liang, S., Pang, M., & Lin, J. (2019) · Advanced Science · doi:10.1002/advs.201900848 · Cited by 209
Retracted
Adaptive Mechanisms of Tumor Therapy Resistance Driven by Tumor Microenvironment
Wu, P., Gao, W. Q., Su, M., Nice, E. C., Zhang, W., Lin, J., & Xie, N. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.641469 · Cited by 218
Cancer stem cells and human malignant melanoma
Schatton, T., & Frank, M. H. (2008) · Pigment Cell & Melanoma Research · doi:10.1111/j.1755-148x.2007.00427.x · Cited by 219
Methylation-dependent regulation of HIF-1α stability restricts retinal and tumour angiogenesis
Kim, Y., Nam, H. J., Lee, J., Park, D. Y., Kim, C., Yu, Y. S., Kim, D., Park, S. W., Bhin, J., Hwang, D., et al. (2016) · Nature Communications · doi:10.1038/ncomms10347 · Cited by 218
Thioredoxin and Cancer: A Role for Thioredoxin in all States of Tumor Oxygenation
Karlenius, T., & Tonissen, K. F. (2010) · Cancers · doi:10.3390/cancers2020209 · Cited by 215
Macrophage Migration Inhibitory Factor: A Probable Link between Inflammation and Cancer
Bucala, R., & Donnelly, S. C. (2007) · Immunity · doi:10.1016/j.immuni.2007.03.005 · Cited by 210
Hypoxia-Inducible Factors Have Distinct and Stage-Specific Roles during Reprogramming of Human Cells to Pluripotency
Mathieu, J., Zhou, W., Xing, Y., Sperber, H., Ferreccio, A., Agoston, Z., Kuppusamy, K. T., Moon, R. T., & Ruohola‐Baker, H. (2014) · Cell stem cell · doi:10.1016/j.stem.2014.02.012 · Cited by 217
Targeted therapy for cancer using pH-responsive nanocarrier systems
Manchun, S., Dass, C. R., & Sriamornsak, P. (2012) · Life Sciences · doi:10.1016/j.lfs.2012.01.008 · Cited by 208
Hypoxia as a barrier to immunotherapy in pancreatic adenocarcinoma
Daniel, S. K., Sullivan, K. M., Labadie, K. P., & Pillarisetty, V. G. (2019) · Clinical and Translational Medicine · doi:10.1186/s40169-019-0226-9 · Cited by 215
Autophagy in cancer development, immune evasion, and drug resistance
Niu, X., You, Q., Hou, K., Tian, Y., Wei, P., Zhu, Y., Gao, B., Ashrafizadeh, M., Aref, A. R., Kalbasi, A., et al. (2024) · Drug Resistance Updates · doi:10.1016/j.drup.2024.101170 · Cited by 244
Genetic Disruption of the Multifunctional CD98/LAT1 Complex Demonstrates the Key Role of Essential Amino Acid Transport in the Control of mTORC1 and Tumor Growth
Cormerais, Y., Giuliano, S., LeFloch, R., Front, B., Durivault, J., Tambutté, É., Massard, P.-A., de la Ballina, L. R., Endou, H., Wempe, M. F., et al. (2016) · Cancer Research · doi:10.1158/0008-5472.can-15-3376 · Cited by 216
Self-citation
Carbonic anhydrase IX, a hypoxia-induced catalytic component of the pH regulating machinery in tumors
Sedlakova, O. (2014) · Frontiers in Physiology · doi:10.3389/fphys.2013.00400 · Cited by 213
Advanced Near‐Infrared Light for Monitoring and Modulating the Spatiotemporal Dynamics of Cell Functions in Living Systems
Chen, G., Cao, Y., Tang, Y., Yang, X., Liu, Y., Huang, D., Zhang, Y., Li, C., & Wang, Q. (2020) · Advanced Science · doi:10.1002/advs.201903783 · Cited by 203
How does cancer cell metabolism affect tumor migration and invasion?
Han, T., Kang, D., Ji, D., Wang, X., Zhan, W., Fu, M., Xin, H.-B., & Wang, J.-B. (2013) · Cell Adhesion & Migration · doi:10.4161/cam.26345 · Cited by 198
Autophagy: Regulation and role in disease
Meijer, A. J., & Codogno, P. (2009) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408360903044068 · Cited by 215
Glucose metabolism in cancer cells
Annibaldi, A., & Widmann, C. (2010) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e32833a5577 · Cited by 202
The role of cancer-associated fibroblasts, solid stress and other microenvironmental factors in tumor progression and therapy resistance
Kharaishvili, G., Simkova, D., Bouchalova, K., Gachechiladze, M., Narsia, N., & Bouchal, J. (2014) · Cancer Cell International · doi:10.1186/1475-2867-14-41 · Cited by 197
Regulation of HIF-1α and VEGF by miR-20b Tunes Tumor Cells to Adapt to the Alteration of Oxygen Concentration
Zhang, L., Li, B., Yang, Z., Fang, H., Zhang, G., Feng, Z., & Huang, B. (2009) · PLoS ONE · doi:10.1371/journal.pone.0007629 · Cited by 198
Oncolytic virotherapy: Molecular targets in tumor-selective replication and carrier cell-mediated delivery of oncolytic viruses
Guo, Z. S., Thorne, S. H., & Bartlett, D. L. (2008) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2008.02.001 · Cited by 198
Extracellular acidity, a “reappreciated” trait of tumor environment driving malignancy: perspectives in diagnosis and therapy
Peppicelli, S., Bianchini, F., & Calorini, L. (2014) · Cancer and Metastasis Reviews · doi:10.1007/s10555-014-9506-4 · Cited by 195
Optical Redox Ratio Differentiates Breast Cancer Cell Lines Based on Estrogen Receptor Status
Ostrander, J. H., McMahon, C. M., Lem, S., Millon, S. R., Brown, J. Q., Seewaldt, V. L., & Ramanujam, N. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-2572 · Cited by 193
Nonlinear simulation of the effect of microenvironment on tumor growth
Macklin, P., & Lowengrub, J. S. (2006) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2006.12.004 · Cited by 192
LC3, an autophagosome marker, is highly expressed in gastrointestinal cancers
Yoshioka (1992) · International Journal of Oncology · doi:10.3892/ijo_00000028 · Cited by 192
Nitric Oxide, Cytochrome C Oxidase, and the Cellular Response to Hypoxia
Taylor, C. T., & Moncada, S. (2010) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.108.181628 · Cited by 220
The role of microRNA deregulation in the pathogenesis of adrenocortical carcinoma
Özata, D. M., Caramuta, S., Velázquez‐Fernández, D., Akçakaya, P., Xie, H. Y., Höög, A., Zedenius, J., Bäckdahl, M., Larsson, C., & Lui, W. (2011) · Endocrine Related Cancer · doi:10.1530/erc-11-0082 · Cited by 199
Carbonic Anhydrase IX Interacts with Bicarbonate Transporters in Lamellipodia and Increases Cell Migration via Its Catalytic Domain
Švastová, E., Witarski, W., Csáderová, L., Košík, I., Škvarková, L., Hulı́ková, A., Zaťovičová, M., Baráthová, M., Kopáček, J., Pastorek, J., et al. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.286062 · Cited by 190
Detection and isolation of circulating tumor cells: Principles and methods
Esmaeilsabzali, H., Beischlag, T. V., Cox, M., Parameswaran, A. M., & Park, E. J. (2013) · Biotechnology Advances · doi:10.1016/j.biotechadv.2013.08.016 · Cited by 194
CD73 on cancer-associated fibroblasts enhanced by the A2B-mediated feedforward circuit enforces an immune checkpoint
Yu, M., Guo, G. F., Huang, L., Deng, L., Chang, C.-S., Achyut, B. R., Canning, M. T., Xu, N., Arbab, A. S., Bollag, R. J., et al. (2020) · Nature Communications · doi:10.1038/s41467-019-14060-x · Cited by 196
HIF2α–arginase axis is essential for the development of pulmonary hypertension
Cowburn, A. S., Crosby, A., Macías, D., Branco, C. M., Colaço, R., Southwood, M. R., Toshner, M. R., Alexander, L. E. C., Morrell, N. W., Chilvers, E. R., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1602978113 · Cited by 187
O 2 -Cu/ZIF-8@Ce6/ZIF-8@F127 Composite as a Tumor Microenvironment-Responsive Nanoplatform with Enhanced Photo-/Chemodynamic Antitumor Efficacy
Xie, Z., Liang, S., Cai, X., Ding, B., Huang, S., Hou, Z., Ma, P., Cheng, Z., & Lin, J. (2019) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.9b10685 · Cited by 188
Carbonic Anhydrase Inhibitors Targeting Metabolism and Tumor Microenvironment
Angeli, A., Carta, F., Nocentini, A., Winum, J., Žalubovskis, R., Akdemir, A., Onnis, V., Eldehna, W. M., Capasso, C., Simone, G. D., et al. (2020) · Metabolites · doi:10.3390/metabo10100412 · Cited by 187
Redox regulation of the hypoxia-inducible factor
Pouysségur, J., & Mechta-Grigoriou, F. (2006) · Biological Chemistry · doi:10.1515/bc.2006.167 · Cited by 186
Self-citation
Increased Oxidative Stress as a Selective Anticancer Therapy
Liu, J., & Wang, Z. (2015) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2015/294303 · Cited by 191
Role of hypoxia-inducible factor-1α in angiogenic–osteogenic coupling
Riddle, R. C., Khatri, R., Schipani, E., & Clemens, T. L. (2009) · Journal of Molecular Medicine · doi:10.1007/s00109-009-0477-9 · Cited by 186

Authors: Pouysségur, J., Dayan, F., & Mazure, N. M.
Affiliations: Centre National de la Recherche Scientifique (FR)
Corresponding author: Pouysségur, Jacques
ORCID: Pouysségur, Jacques
Mazure, Nathalie M.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2006-05-24
Volume: 441
Issue: 7092
Pages: 437-443
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature04871
OpenAlex: W2082483448
Semantic Scholar: 5bbdcf74ee4cdf263a532b6dbae0b8dd5efb9722
Cited by: 1,676
References: 104
Citations by year: 2026: 19 · 2025: 39 · 2024: 48 · 2023: 75 · 2022: 85 · 2021: 97 · 2020: 87 · 2019: 77 · 2018: 81 · 2017: 68 · 2016: 85 · 2015: 80 · 2014: 103 · 2013: 104 · 2012: 89
FWCI: 6.91
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Funders: Ligue Contre le Cancer
Centre National de la Recherche Scientifique
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Ferroptosis and cancer prognosis
Keywords: hypoxia signaling, hypoxia-inducible factor, tumor hypoxia, tumor regression, cancer metabolism, intracellular pH regulation, tumor angiogenesis, glucose metabolism, necrosis, autophagy, cell invasion, cancer therapy, tumor oxygenation
MeSH terms: Animals, Humans, Neoplasms, Neovascularization, Pathologic, Oxygen, Protein Kinases, Signal Transduction, Cell Hypoxia, TOR Serine-Threonine Kinases

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Hypoxia signalling in cancer and approaches to enforce tumour regression

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks