Hypoxia signalling in cancer and approaches to enforce tumour regression

The biology of VEGF and its receptors

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Targeting HIF-1 for cancer therapy

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Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O 2 -Regulated Prolyl Hydroxylation

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Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene

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Angiopoietin-2, a Natural Antagonist for Tie2 That Disrupts in vivo Angiogenesis

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C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

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VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia

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AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism

Kahn, B. B., Alquier, T., Carling, D., & Hardie, D. G. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2004.12.003 · Cited by 2,799

Angiogenesis as a therapeutic target

Ferrara, N., & Kerbel, R. S. (2005) · Nature · doi:10.1038/nature04483 · Cited by 2,653

Impact of cyclic hypoxia on HIF‐1α regulation in endothelial cells – new insights for anti‐tumor treatments

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HIF-1α stimulates the progression of oesophageal squamous cell carcinoma by activating the Wnt/β-catenin signalling pathway

Tang, K. L., Toyozumi, T., Murakami, K., Sakata, H., Kano, M., Endo, S., Matsumoto, Y., Suito, H., Takahashi, M., Sekino, N., et al. (2022) · British Journal of Cancer · doi:10.1038/s41416-022-01825-3 · Cited by 43

The Role of the Hypoxia-Related Unfolded Protein Response (UPR) in the Tumor Microenvironment

Bartoszewska, S., Collawn, J. F., & Bartoszewski, R. (2022) · Cancers · doi:10.3390/cancers14194870 · Cited by 43

Hypoxic conditions differentially regulate TAZ and YAP in cancer cells

Yan, L., Cai, Q., & Xu, Y. (2014) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2014.07.024 · Cited by 43

Doxorubicin and Fe 3 O 4 loaded albumin nanoparticles with folic acid modified dextran surface for tumor diagnosis and therapy

Hao, H., Ma, Q., He, F., & Yao, P. (2014) · Journal of Materials Chemistry B · doi:10.1039/c4tb01359j · Cited by 43

Intracellular Carbonic Anhydrase Activity Sensitizes Cancer Cell pH Signaling to Dynamic Changes in CO2 Partial Pressure

Hulı́ková, A., Aveyard, N., Harris, A. L., Vaughan‐Jones, R. D., & Swietach, P. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.547844 · Cited by 43

ZEB1 transcriptionally regulated carbonic anhydrase 9 mediates the chemoresistance of tongue cancer via maintaining intracellular pH

Zheng, G., Peng, C., Jia, X., Gu, Y., Zhang, Z., Deng, Y., Wang, C., Li, N., Yin, J., Liu, X., et al. (2015) · Molecular Cancer · doi:10.1186/s12943-015-0357-6 · Cited by 43

Targeting Angiogenesis in Esophagogastric Adenocarcinoma

Okines, A. F. C., Reynolds, A. R., & Cunningham, D. (2011) · The Oncologist · doi:10.1634/theoncologist.2010-0387 · Cited by 43

Novel approaches for designing drugs that interfere with pH regulation

Berrino, E., & Supuran, C. T. (2019) · Expert Opinion on Drug Discovery · doi:10.1080/17460441.2019.1567488 · Cited by 43

Downregulation of Hypoxia-Inducible Factor-1α by RNA Interference Alleviates the Development of Collagen-Induced Arthritis in Rats

Hu, Y., Zhang, T., Chen, J., Cheng, W., Chen, J., Zheng, Z., Lin, J., Zhu, G., Zhang, Y., Bai, X., et al. (2020) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2020.01.014 · Cited by 43

Jet‐Lagged Nanoparticles Enhanced Immunotherapy Efficiency through Synergistic Reconstruction of Tumor Microenvironment and Normalized Tumor Vasculature

Jiang, Z., Xiong, H., Yang, S., Lü, Y., Deng, Y., Yao, J., & Yao, J. (2020) · Advanced Healthcare Materials · doi:10.1002/adhm.202000075 · Cited by 42

Understanding the Role of Innate Immune Cells and Identifying Genes in Breast Cancer Microenvironment

Shihab, I., Khalil, B. A., Elemam, N. M., Hachim, I. Y., Hachim, M. Y., Hamoudi, R., & Maghazachi, A. A. (2020) · Cancers · doi:10.3390/cancers12082226 · Cited by 42

Design strategies and applications of smart optical probes in the second near-infrared window

Chang, B., Chen, J., Bao, J., Dong, K., Chen, S., & Cheng, Z. (2022) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2022.114637 · Cited by 46

Hypoxia Inducible Factor-1α Inactivation Unveils a Link between Tumor Cell Metabolism and Hypoxia-Induced Cell Death

Favaro, E., Nardo, G., Persano, L., Masiero, M., Moserle, L., Zamarchi, R., Rossi, E. M. C., Esposito, G., Plebani, M., Sattler, U. G. A., et al. (2008) · American Journal Of Pathology · doi:10.2353/ajpath.2008.071183 · Cited by 42

Pioglitazone enhances collateral blood flow in ischemic hindlimb of diabetic mice through an Akt-dependent VEGF-mediated mechanism, regardless of PPARγ stimulation

Biscetti, F., Straface, G., Arena, V., Stigliano, E., Pecorini, G., Rizzo, P., Angelis, G. D., Iuliano, L., Ghirlanda, G., & Flex, A. (2009) · Cardiovascular Diabetology · doi:10.1186/1475-2840-8-49 · Cited by 43

Biosensors to Monitor Cell Activity in 3D Hydrogel-Based Tissue Models

Fedi, A., Vitale, C., Giannoni, P., Caluori, G., & Marrella, A. (2022) · Sensors · doi:10.3390/s22041517 · Cited by 46

The emerging role of mammalian target of rapamycin inhibitors in the treatment of sarcomas

Vemulapalli, S., Mita, A. C., Alvarado, Y., Sankhala, K. K., & Mita, M. M. (2011) · Targeted Oncology · doi:10.1007/s11523-011-0179-4 · Cited by 42

Hypoxia-inducible factor inhibitors: a survey of recent patented compounds (2004 - 2010)

Ban, H. S., Uto, Y., & Nakamura, H. (2011) · Expert Opinion on Therapeutic Patents · doi:10.1517/13543776.2011.547477 · Cited by 42

Pathophysiological Response to Hypoxia — From the Molecular Mechanisms of Malady to Drug Discovery: Epigenetic Regulation of the Hypoxic Response via Hypoxia-Inducible Factor and Histone Modifying Enzymes

Mimura, I., Tanaka, T., Wada, Y., Kodama, T., & Nangaku, M. (2011) · Journal of Pharmacological Sciences · doi:10.1254/jphs.10r19fm · Cited by 42

Parallel In Vivo and In Vitro Melanoma RNAi Dropout Screens Reveal Synthetic Lethality between Hypoxia and DNA Damage Response Inhibition

Possik, P. A., Müller, J., Gerlach, C., Kenski, J. C. N., Huang, X., Shahrabi, A., Krijgsman, O., Song, J., Smit, M. A., Gerritsen, B., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.10.024 · Cited by 43

Interaction with ErbB4 Promotes Hypoxia-inducible Factor-1α Signaling

Paatero, I., Jokilammi, A., Heikkinen, P. T., Iljin, K., Kallioniemi, O., Jones, F. E., Jaakkola, P., & Elenius, K. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.299537 · Cited by 46

The VHL/HIF Axis in the Development and Treatment of Pheochromocytoma/Paraganglioma

Song, P., Zhang, J., Tan, X., Huang, Y., Xu, J., Silk, N., Zhang, D., Liu, Q., & Jiang, J. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.586857 · Cited by 42

Vascular Endothelial Growth Factor: A Translational View in Oral Non-Communicable Diseases

Niklander, S. E., Bordagaray, M. J., Fernández, A., V, & Hernández, M. (2021) · Biomolecules · doi:10.3390/biom11010085 · Cited by 47

Oncostatic effects of fluoxetine in experimental colon cancer models

Kannen, V., Garcia, S. B., Silva, W. A., Gasser, M., Moench, R., Alho, E. J. L., Heinsen, H., Scholz, C. J., Friedrich, M., Heinze, K. G., et al. (2015) · Cellular Signalling · doi:10.1016/j.cellsig.2015.05.008 · Cited by 42

Ferrocene‐Containing Nucleic Acid‐Based Energy‐Storage Nanoagent for Continuously Photo‐Induced Oxidative Stress Amplification

Ji, C., Li, H., Zhang, L., Wang, P., Lv, Y., Sun, Z., Tan, J., Yuan, Q., & Tan, W. (2022) · Angewandte Chemie International Edition · doi:10.1002/anie.202200237 · Cited by 42

Hypoxia induced overexpression of PrPC in gastric cancer cell lines

Liang, J., Bai, F., Luo, G., Wang, J., Liu, J., Ge, F., Pan, Y., Yao, L., Du, R., Li, X., et al. (2007) · Cancer Biology & Therapy · doi:10.4161/cbt.6.5.4001 · Cited by 41

HIF mediated and DNA damage independent histone H2AX phosphorylation in chronic hypoxia

Wrann, S., Kaufmann, M. R., Wirthner, R., Stiehl, D. P., & Wenger, R. H. (2012) · Biological Chemistry · doi:10.1515/hsz-2012-0311 · Cited by 41

HS-1793, a resveratrol analogue, downregulates the expression of hypoxia-induced HIF-1 and VEGF and inhibits tumor growth of human breast cancer cells in a nude mouse xenograft model

Kim, D. H., Sung, B., Kim, J.-A., Kang, Y. J., Hwang, S. Y., Hwang, N. L., Suh, H., Choi, Y. H., Im, E., Chung, H. Y., et al. (2017) · International Journal of Oncology · doi:10.3892/ijo.2017.4058 · Cited by 42

Hypoxia, hypoxia-inducible factors and fibrogenesis in chronic liver diseases.

Cannito, S., Paternostro, C., Busletta, C., Bocca, C., Colombatto, S., Miglietta, A., Novo, E., & Parola, M. (2014) · PubMed · doi:10.14670/hh-29.33 · Cited by 41

Cancer cell-associated cytoplasmic B7–H4 is induced by hypoxia through hypoxia-inducible factor-1α and promotes cancer cell proliferation

Jeon, Y.-K., Park, S.-G., Choi, I.-W., Lee, S.-W., Lee, S. M., & Choi, I. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.02.098 · Cited by 41

Oct‐3/4 promotes migration and invasion of glioblastoma cells

Kobayashi, K., Takahashi, H., Inoue, A., Harada, H., Toshimori, S., Kobayashi, Y., Katsuhiro, G. O. T. O., Sugimoto, K., Yano, H., Ohnishi, T., et al. (2011) · Journal of Cellular Biochemistry · doi:10.1002/jcb.23374 · Cited by 43

Apolipoprotein A-I Mimetic Peptides Inhibit Expression and Activity of Hypoxia-Inducible Factor-1α in Human Ovarian Cancer Cell Lines and a Mouse Ovarian Cancer Model

Gao, F., Chattopadhyay, A., Navab, M., Grijalva, V. R., Su, F., Fogelman, A. M., Reddy, S. T., & Farias‐Eisner, R. (2012) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.112.191544 · Cited by 41

Bisecting N-Acetylglucosamine Structures Inhibit Hypoxia-Induced Epithelial-Mesenchymal Transition in Breast Cancer Cells

Tan, Z., Wang, C., Li, X., & Guan, F. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00210 · Cited by 42

Inhibition of miR-135b by SP-1 promotes hypoxia-induced vascular endothelial cell injury via HIF-1α

Yang, S., Yin, J. Y., & Hou, X. (2018) · Experimental Cell Research · doi:10.1016/j.yexcr.2018.06.001 · Cited by 41

Targeting the Tumor Microenvironment: A Literature Review of the Novel Anti-Tumor Mechanism of Statins

Zhu, P., Wang, M., Chen, Z.-L., & Yang, L. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.761107 · Cited by 45

Resveratrol Reduces the Hypoxia-Induced Resistance to Doxorubicin in Breast Cancer Cells

Mitani, T., Ito, Y., Harada, N., Nakano, Y., Inui, H., Ashida, H., & Yamaji, R. (2014) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.60.122 · Cited by 41

Patterns of tumor oxygenation and their influence on the cellular hypoxic response and hypoxia-directed therapies

Magagnin, M. G., Koritzinsky, M., & Wouters, B. G. (2006) · Drug Resistance Updates · doi:10.1016/j.drup.2006.07.002 · Cited by 41

Assessment of Hypoxia Inducible Factor Levels in Cancer Cell Lines upon Hypoxic Induction Using a Novel Reporter Construct

Zhou, W., Dosey, T. L., Biechele, T. L., Moon, R. T., Horwitz, M. S., & Ruohola‐Baker, H. (2011) · PLoS ONE · doi:10.1371/journal.pone.0027460 · Cited by 41

Role of Carcinoma-Associated Fibroblasts and Hypoxia in Tumor Progression

Giaccia, A. J., & Schipani, E. (2010) · Current topics in microbiology and immunology · doi:10.1007/82_2010_73 · Cited by 43

Loss of fatty acid synthase suppresses the malignant phenotype of colorectal cancer cells by down-regulating energy metabolism and mTOR signaling pathway

Chang, L., Wu, P., Senthilkumar, R., Tian, X., Liu, H., Shen, X., Tao, Z., & Huang, P. (2015) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-015-2000-8 · Cited by 39

Dermcidin expression confers a survival advantage in prostate cancer cells subjected to oxidative stress or hypoxia

Stewart, G. D., Lowrie, A. G., Riddick, A. C. P., Fearon, K. C. H., Habib, F. K., & Ross, J. A. (2007) · The Prostate · doi:10.1002/pros.20618 · Cited by 41

Hypoxia-induced autophagic response is associated with aggressive phenotype and elevated incidence of metastasis in orthotopic immunocompetent murine models of head and neck squamous cell carcinomas (HNSCC)

Vigneswaran, N., Wu, J. G., Song, A., Annapragada, A., & Zacharias, W. (2011) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2010.11.011 · Cited by 40

Increased adipose tissue hypoxia and capacity for angiogenesis and inflammation in young diet-sensitive C57 mice compared with diet-resistant FVB mice

Kim, D.-H., Gutiérrez‐Aguilar, R., Kim, H.-J., Woods, S. C., & Seeley, R. J. (2012) · International Journal of Obesity · doi:10.1038/ijo.2012.141 · Cited by 42

Immunohistochemical study of VEGF expression in oral squamous cell carcinomas: correlation with the mTOR-HIF-1α pathway.

Naruse, T., Kawasaki, G., Yanamoto, S., Mizuno, A., & Umeda, M. (2011) · PubMed · Cited by 40

Resistance of glioma cells to nutrient-deprived microenvironment can be enhanced by CD133-mediated autophagy

Sun, H., Zhang, M., Cheng, K., Li, P., Han, S., Li, R., Su, M., Zeng, W., Liu, J., Guo, J., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.12803 · Cited by 40

Glucose Metabolism Reprogrammed by Overexpression of IKKϵ Promotes Pancreatic Tumor Growth

Zubair, H., Azim, S., Srivastava, S. K., Ahmad, A., Bhardwaj, A., Khan, M. A., Patel, G. K., Arora, S., Carter, J. E., Singh, S., et al. (2016) · Cancer Research · doi:10.1158/0008-5472.can-16-1666 · Cited by 40

Cellular Phenotype Plasticity in Cancer Dormancy and Metastasis

Yang, X., Liang, X., Zheng, M. H., & Tang, Y. (2018) · Frontiers in Oncology · doi:10.3389/fonc.2018.00505 · Cited by 42

Together we stand, apart we fall: how cell-to-cell contact/interplay provides resistance to ferroptosis

Vučetić, M., Daher, B., Cassim, S., Meira, W., & Pouysségur, J. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-02994-w · Cited by 40

Caspase-Independent Regulated Necrosis Pathways as Potential Targets in Cancer Management

Lou, J., Zhou, Y., Feng, Z., Ma, M., Yao, Y., Wang, Y., Deng, Y., & Wu, Y. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2020.616952 · Cited by 39

Erratum to: A Phase 1 dose-escalation study of the safety and pharmacokinetics of once-daily oral foretinib, a multi-kinase inhibitor, in patients with solid tumors

Shapiro, G. I., McCallum, S. W., Adams, L. M., Sherman, L. J., Weller, S., Swann, S., Keer, H. N., Miles, D., Müller, T. R., Rabe, D. C., et al. (2015) · Investigational New Drugs · doi:10.1007/s10637-015-0287-6 · Cited by 40

Perspectives on Hypoxia Signaling in Tumor Stroma

Zhang, Y., Coleman, M., & Brekken, R. A. (2021) · Cancers · doi:10.3390/cancers13123070 · Cited by 39

Proton-coupled monocarboxylate transporters in cancer: From metabolic crosstalk, immunosuppression and anti-apoptosis to clinical applications

Duan, Q., Zhang, S., Wang, Y., Lu, D., Sun, Y., & Wu, Y. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.1069555 · Cited by 40

Fatty liver creates a pro‐metastatic microenvironment for hepatocellular carcinoma through activation of hepatic stellate cells

Mikuriya, Y., Tashiro, H., Kuroda, S., Nambu, J., Kobayashi, T., Amano, H., Tanaka, Y., & Ohdan, H. (2014) · International Journal of Cancer · doi:10.1002/ijc.29096 · Cited by 38

Erythropoietin gene expression in renal carcinoma is considerably more frequent than paraneoplastic polycythemia

Wiesener, M. S., Münchenhagen, P., Gläser, M., Sobottka, B., Knaup, K. X., Jozefowski, K., Jürgensen, J. S., Roigas, J., Warnecke, C., Gröne, H., et al. (2007) · International Journal of Cancer · doi:10.1002/ijc.22961 · Cited by 40

Angiogenesis and tumor microenvironment: bevacizumab in the breast cancer model

Trédan, O., Lacroix‐Triki, M., Guiu, S., Mouret‐Reynier, M., Barrière, J., Bidard, F., Braccini, A.-L., Mir, O., Villanueva, C., & Barthélémy, P. (2014) · Targeted Oncology · doi:10.1007/s11523-014-0334-9 · Cited by 42

Hypoxia-Mediated Impairment of the Mitochondrial Respiratory Chain Inhibits the Bactericidal Activity of Macrophages

Wiese, M., Gerlach, R. G., Popp, I., Matuszak, J., Mahapatro, M., Castiglione, K., Chakravortty, D., Willam, C., Hensel, M., Bogdan, C., et al. (2012) · Infection and Immunity · doi:10.1128/iai.05972-11 · Cited by 39

Active autophagy in the tumor microenvironment: A novel mechanism for cancer metastasis

Xu, Y., Xia, X., & Pan, H. (2012) · Oncology Letters · doi:10.3892/ol.2012.1015 · Cited by 39

Cell physiology regulation by hypoxia inducible factor-1: Targeting oxygen-related nanomachineries of hypoxic cells

Eskandani, M., Vandghanooni, S., Barar, J., Nazemiyeh, H., & Omidi, Y. (2017) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2016.10.113 · Cited by 40

Cardiac glycosides suppress the maintenance of stemness and malignancy via inhibiting HIF-1α in human glioma stem cells

Lee, D.-H., Oh, S. C., Giles, A. J., Jung, J., Gilbert, M. R., & Park, D. M. (2017) · Oncotarget · doi:10.18632/oncotarget.16714 · Cited by 40

Reduced production and uptake of lactate are essential for the ability of WNT5A signaling to inhibit breast cancer cell migration and invasion

Prasad, C. P., Södergren, K., & Andersson, T. (2017) · Oncotarget · doi:10.18632/oncotarget.17277 · Cited by 39

Stimuli-Regulated Smart Polymeric Systems for Gene Therapy

Mathew, A. P., Cho, K., Uthaman, S., Cho, C., & Park, I. (2017) · Polymers · doi:10.3390/polym9040152 · Cited by 39

Cardiovascular adaptation to hypoxia and the role of peripheral resistance

Cowburn, A., Macías, D., Summers, C., Chilvers, E., & Johnson, R. (2017) · eLife · doi:10.7554/elife.28755 · Cited by 33

Anti-Invasion and Antiangiogenic Effects of Stellettin B through Inhibition of the Akt/Girdin Signaling Pathway and VEGF in Glioblastoma Cells

Cheng, S.-Y., Chen, N., Lin, P., Su, J., Chen, B., Kuo, H., Sung, C., Sung, P., Wen, Z., & Chen, W.-F. (2019) · Cancers · doi:10.3390/cancers11020220 · Cited by 39

miR‐210 Participates in Hepatic Ischemia Reperfusion Injury by Forming a Negative Feedback Loop With SMAD4

Pan, W., Wang, H., Zhang, X., Xu, P., Wang, G., Li, Y., Huang, K., Zhang, Y., Zhao, H., Du, R., et al. (2020) · Hepatology · doi:10.1002/hep.31221 · Cited by 40

Associations of self-reported obstructive sleep apnea with total and site-specific cancer risk in older women: a prospective study

Huang, T., Lin, B. M., Stampfer, M. J., Schernhammer, E. S., Saxena, R., Tworoger, S. S., & Redline, S. S. (2020) · SLEEP · doi:10.1093/sleep/zsaa198 · Cited by 41

Radiation-induced modifications of the tumor microenvironment promote metastasis

Rüegg, C., Monnier, Y., Kuonen, F., & Imaizumi, N. (2011) · Bulletin du Cancer · doi:10.1684/bdc.2011.1372 · Cited by 39

Dissecting the roles and clinical potential of YY1 in the tumor microenvironment

Li, M., Wei, J., Xue, C., Zhou, X., Chen, S., Zheng, L., Duan, Y., Deng, H., Xiong, W., Tang, F., et al. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1122110 · Cited by 39

The asparaginyl hydroxylase factor-inhibiting HIF is essential for tumor growth through suppression of the p53–p21 axis

Pelletier, J., Dayan, F., Durivault, J., Ilc, K., Pécou, E., Pouysségur, J., & Mazure, N. M. (2011) · Oncogene · doi:10.1038/onc.2011.471 · Cited by 41

Pharmacological insights into antioxidants against colorectal cancer: A detailed review of the possible mechanisms

Gothai, S., Muniandy, K., Gnanaraj, C., Ibrahim, I. A. A., Shahzad, N., Alghamdi, S., Ayoub, N., Veeraraghavan, V. P., Kumar, S. S., Norhaizan, M. E., et al. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.08.112 · Cited by 38

Exploiting Nanomaterial‐Mediated Autophagy for Cancer Therapy

Wei, W., Rosenkrans, Z. T., Luo, Q., Lan, X., & Cai, W. (2018) · Small Methods · doi:10.1002/smtd.201800365 · Cited by 41

Autophagy: A Key Player in Pancreatic Cancer Progression and a Potential Drug Target

Gillson, J., El-Aziz, Y. S. A., Leck, L. Y. W., Jansson, P. J., Pavlakis, N., Samra, J. S., Mittal, A., & Sahni, S. (2022) · Cancers · doi:10.3390/cancers14143528 · Cited by 38

Prolidase-dependent regulation of TGF c and TGF β receptor expressions in human skin fibroblasts

Surażyński, A., Miltyk, W., Prokop, I., & Palka, J. A. (2010) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2010.09.034 · Cited by 38

Impact of hexavalent chromium on mammalian cell bioenergetics: phenotypic changes, molecular basis and potential relevance to chromate-induced lung cancer

Abreu, P. L., Ferreira, L. M. R., Alpoim, M. C., & Urbano, A. M. (2014) · BioMetals · doi:10.1007/s10534-014-9726-7 · Cited by 39

Effect of HIF-1 modulation on the response of two- and three-dimensional cultures of human colon cancer cells to 5-fluorouracil

Ravizza, R., Molteni, R., Gariboldi, M. B., Marras, E., Perletti, G., & Monti, E. (2009) · European Journal of Cancer · doi:10.1016/j.ejca.2008.12.021 · Cited by 38

Vascular endothelial growth factor and angiopoietin-2 play a major role in the pathogenesis of vascular leakage in cirrhotic rats

Melgar‐Lesmes, P., Tugues, S., Ros, J., Fernández‐Varo, G., Morales‐Ruiz, M., Rodés, J., & Jiménez, W. (2008) · Gut · doi:10.1136/gut.2008.155028 · Cited by 38

FBP1 modulates cell metabolism of breast cancer cells by inhibiting the expression of HIF-1α

Shi, L., He, C., Li, Z., Wang, Z., & Zhang, Q. (2017) · Neoplasma · doi:10.4149/neo_2017_407 · Cited by 39

Inhibitor of nuclear factor‐kappaB alpha derepresses hypoxia‐inducible factor‐1 during moderate hypoxia by sequestering factor inhibiting hypoxia‐inducible factor from hypoxia‐inducible factor 1α

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Targeting vasculature in urologic tumors: Mechanistic and therapeutic significance

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