The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
CD38 is critical for social behaviour by regulating oxytocin secretion
Abstract
CD38, a transmembrane glycoprotein with ADP-ribosyl cyclase activity, catalyses the formation of Ca2+ signalling molecules, but its role in the neuroendocrine system is unknown. Here we show that adult CD38 knockout (CD38-/-) female and male mice show marked defects in maternal nurturing and social behaviour, respectively, with higher locomotor activity. Consistently, the plasma level of oxytocin (OT), but not vasopressin, was strongly decreased in CD38-/- mice. Replacement of OT by subcutaneous injection or lentiviral-vector-mediated delivery of human CD38 in the hypothalamus rescued social memory and maternal care in CD38-/- mice. Depolarization-induced OT secretion and Ca2+ elevation in oxytocinergic neurohypophysial axon terminals were disrupted in CD38-/- mice; this was mimicked by CD38 metabolite antagonists in CD38+/+ mice. These results reveal that CD38 has a key role in neuropeptide release, thereby critically regulating maternal and social behaviours, and may be an element in neurodevelopmental disorders.
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In the citing paper
“A seminal study showed that OTR and D2 receptor activation must occur concurrently for partner preference to develop in female prairie voles [66].”
From Oxytocin and the Neural Mechanisms Regulating Social Cognition and Affiliative Behavior (2009) · cites this paper as [66]
In the citing paper
“In addition, research has pointed to the central role of transmembrane glycoprotein CD38 in OT neuropathways and in the release of OT from axon terminalis (Jin et al., 2007), and recent findings showed associations between plasma OT, genetic variability in the CD38 rs3796863 SNP, and the degree of reciprocity and touch between parents and their infants (Feldman et al., in press), pointing to the”
From Oxytocin during the initial stages of romantic attachment: Relations to couples’ interactive reciprocity (2012) · cites this paper as Jin et al., 2007
In the citing paper
“Blockade of D2 receptors in the NAcc shell prevented OT-mediated partner preferences, while blockade of OTR in the NAcc shell prevented D2 receptor mediated partner preferences in female prairie voles.”
From Oxytocin and the Neural Mechanisms Regulating Social Cognition and Affiliative Behavior (2009) · cites this paper as [66]
In the citing paper
“Blockade of D2 receptors in the NAcc shell prevented OT-mediated partner preferences,”
From Oxytocin and the Neural Mechanisms Regulating Social Cognition and Affiliative Behavior (2009) · cites this paper as [66]
In the citing paper
“Blockade of D2 receptors in the NAcc shell prevented OT-mediated partner preferences, while blockade of OTR in the NAcc shell prevented D2 receptor mediated partner preferences in female prairie voles.”
From Oxytocin and the Neural Mechanisms Regulating Social Cognition and Affiliative Behavior (2009) · cites this paper as [66]
In the citing paper
“CD38 catalyzes the synthesis of the Ca2+-responsive messenger cyclic ADP-ribose (cADPR) by use of NAD+ and plays a key role in multiple physiological processes such as immunity, metabolism, inflammation, and even social behaviors (Jin et al., 2007).”
From NAD+ in Brain Aging and Neurodegenerative Disorders (2019) · cites this paper as Jin et al., 2007
In the citing paper
“CD38 was also reported to affect social behaviour, as was its homologue CD157 (REFS166,167)”
From NAD+ metabolism and its roles in cellular processes during ageing (2021) · cites this paper as [166]
In the citing paper
“Mice with impaired OT release or signalling display impairments in maternal responsiveness (3,4).”
From Comparative Perspectives on Oxytocin and Vasopressin Receptor Research in Rodents and Primates: Translational Implications (2016) · cites this paper as [3]
In the citing paper
“The role of the OXT system has been investigated in rodent models, but uniquely using OXT-related mutant mice and giving OXT through intracerebroventricular (ICV), intraperitoneal (IP) and subcutaneous (SC) injections (Bielsky and Young, 2004;Jin et al, 2007;Popik et al, 1996;Sala et al, 2012;Sala et al, 2011;Takayanagi et al, 2005;Winslow and Insel, 2002).”
From Chronic and acute intranasal oxytocin produce divergent social effects in mice (2014) · cites this paper as Jin et al, 2007
In the citing paper
“Specifically, CD38 is involved in oxytocin secretion via Ca2+ release15”
From Oxytocin pathway gene networks in the human brain (2019) · cites this paper as [15]
In the citing paper
“Normal maternal behaviour is restored by peripheral oxcytocin replacement in Oxt−/− and Cd38−/−, but not Oxtr−/− mice, implying that circulating oxcytocin crosses the blood-brain barrier.”
From Vascular RAGE transports oxytocin into the brain to elicit its maternal bonding behaviour in mice (2019) · cites this paper as [5]
In the citing paper
“Loss of maternal nurturing and social interactive behaviours in Cd38−/− mice have been restored following peripheral administration of oxytocin, consistent with transport of peripherally administered exogenous oxytocin into brain5.”
From Vascular RAGE transports oxytocin into the brain to elicit its maternal bonding behaviour in mice (2019) · cites this paper as [5]
In the citing paper
“Compared to placebo, oxytocin administered to eight adolescent and adult males with FXS significantly increased overall eye gaze during a brief social interaction.59 Interestingly, lower doses of oxytocin in this sample appeared to show a greater effect than the higher administered dose, consistent with a recent study in healthy adults.60”
From Beyond the hype and hope: critical considerations for intranasal oxytocin research in autism spectrum disorder (2017) · cites this paper as [60]
In the citing paper
“recent investigations into dose-dependent effects of oxytocin on social cognition have demonstrated superior effects at lower (8 IU) doses.60”
From Beyond the hype and hope: critical considerations for intranasal oxytocin research in autism spectrum disorder (2017) · cites this paper as [60]
In the citing paper
“Initial evidence suggests that lower dose (8IU) oxytocin delivered via this device is effective in modulating aspects of emotional behaviour.60”
From Beyond the hype and hope: critical considerations for intranasal oxytocin research in autism spectrum disorder (2017) · cites this paper as [60]
In the citing paper
“In comparison with wild-type mice, CD38 -/-mice have reduced OXT levels in the plasma and cerebrospinal fluid (CSF) (Jin et al., 2007) but elevated levels in the hypothalamus and pituitary tissues.”
From CD38 and its role in oxytocin secretion and social behavior (2012) · cites this paper as Jin et al., 2007
In the citing paper
“It is also required for normal social behavior in mice (Jin et al., 2007).”
From CD38 and its role in oxytocin secretion and social behavior (2012) · cites this paper as Jin et al., 2007
In the citing paper
“We have recently shown that CD38 is required, as shown by the decreased formation of cADPR and by CICR, for some social behaviors in mice via the regulation of OXT secretion from the hypothalamus and pituitary (Jin et al., 2007;Higashida et al., 2010;Salmina et al., 2010).”
From CD38 and its role in oxytocin secretion and social behavior (2012) · cites this paper as Jin et al., 2007
In the citing paper
“We used a genetic approach to re-express CD38 by infusing a virus carrying the human CD38 gene into the third ventricle of knockout mice.This procedure resulted in the normalization of the plasma and CSF OXT levels, thereby normalizing social memory (see Fig. 2 of Jin et al., 2007).”
From CD38 and its role in oxytocin secretion and social behavior (2012) · cites this paper as Jin et al., 2007
In the citing paper
“In addition, social amnesia was not rescued by the local expression of human R140W-CD38, via a lentiviral infection, in the hypothalamus of CD38 knockout mice (Fig. 2 of Jin et al., 2007).”
From CD38 and its role in oxytocin secretion and social behavior (2012) · cites this paper as Jin et al., 2007
In the citing paper
“The behavioral phenotype of CD38 -/-mice could be normalized by a single subcutaneous OXT injection because OXT is able to enter into the brain, probably through the blood-brain barrier (see Supplementary Fig. S7 of Jin et al., 2007).”
From CD38 and its role in oxytocin secretion and social behavior (2012) · cites this paper as Jin et al., 2007
In the citing paper
“In contrast, CD38 -/-males showed sustained high levels of investigation at every encounter with the same female (Jin et al., 2007).”
From CD38 and its role in oxytocin secretion and social behavior (2012) · cites this paper as Jin et al., 2007
In the citing paper
“These results suggested that CD38 may have an important role in OT release in the human hypothalamus, as in the mice (Jin et al., 2007;Liu et al., 2008).”
From Two genetic variants of CD38 in subjects with autism spectrum disorder and controls (2010) · cites this paper as Jin et al., 2007
In the citing paper
“They showed that CD38 regulates OT secretion in the mouse hypothalamus and posterior pituitary, which is critical for mouse social behavior (Jin et al., 2007;Liu et al., 2008).”
From Two genetic variants of CD38 in subjects with autism spectrum disorder and controls (2010) · cites this paper as Jin et al., 2007
In the citing paper
“Moreover, social amnesia was not rescued by local re-expression of human W140-CD38 in the hypothalamus in the Cd38 null mice (Jin et al., 2007).”
From Two genetic variants of CD38 in subjects with autism spectrum disorder and controls (2010) · cites this paper as Jin et al., 2007
Citations
Cites
Oxytocin increases trust in humans
Kosfeld, M., Heinrichs, M., Zak, P. J., Fischbacher, U., & Fehr, E. (2005) · Nature · doi:10.1038/nature03701 · Cited by 3,690
Cognitive neuroscience of emotional memory
LaBar, K. S., & Cabeza, R. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1825 · Cited by 1,834
Oxytocin Modulates Neural Circuitry for Social Cognition and Fear in Humans
Kirsch, P., Esslinger, C., Chen, Q., Mier, D., Lis, S., Siddhanti, S., Gruppe, H., Mattay, V. S., Gallhofer, B., & Meyer-Lindenberg, A. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.3984-05.2005 · Cited by 1,639
The neurobiology of pair bonding.
Young, L. J., & Wang, Z. (2004) · Nature Neuroscience · doi:10.1038/nn1327 · Cited by 1,523
The neural correlates of maternal and romantic love
Bartels, A., & Zeki, S. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2003.11.003 · Cited by 1,497
The neurobiology of attachment
Insel, T. R., & Young, L. J. (2001) · Nature Reviews Neuroscience · doi:10.1038/35053579 · Cited by 1,173
Social amnesia in mice lacking the oxytocin gene
Ferguson, J. N., Young, L. J., Hearn, E. F., Matzuk, M. M., Insel, T. R., & Winslow, J. T. (2000) · Nature Genetics · doi:10.1038/77040 · Cited by 1,130
Dendritic peptide release and peptide-dependent behaviours
Ludwig, M., & Leng, G. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1845 · Cited by 945
Pervasive social deficits, but normal parturition, in oxytocin receptor-deficient mice
Takayanagi, Y., Yoshida, M., Bielsky, I. F., Ross, H. E., Kawamata, M., Onaka, T., Yanagisawa, T., Kimura, T., Matzuk, M. M., Young, L. J., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0505312102 · Cited by 806
Formation and Hydrolysis of Cyclic ADP-Ribose Catalyzed by Lymphocyte Antigen CD38
Howard, M., Grimaldi, J. C., Bazán, J. F., Lund, F. E., Santos‐Argumedo, L., Parkhouse, R. M. E., Walseth, T. F., & Lee, H. C. (1993) · Science · doi:10.1126/science.8235624 · Cited by 737
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Functional identification of soluble uric acid as an endogenous inhibitor of CD38
Wen, S., Arakawa, H., Yokoyama, S., Shirasaka, Y., Higashida, H., & Tamai, I. (2024) · eLife · doi:10.7554/elife.96962.3 · Cited by 13
Self-citationHidema, S., Sato, K., Mizukami, H., Takahashi, Y., Maejima, Y., Shimomura, K., & Nishimori, K. (2023) · Neuroendocrinology · doi:10.1159/000535362 · Cited by 12
Ramakrishnan, L., Muller‐Steffner, H., Bosc, C., Vacquier, V. D., Schuber, F. J., Moutin, M., Dale, L., & Patel, S. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.105312 · Cited by 12
Gleason, G., Zupan, B., & Tóth, M. (2011) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2011.00025 · Cited by 12
Sex-Specific Social Behavior and Amygdala Proteomic Deficits in Foxp2+/− Mutant Mice
Herrero, M. J., Wang, L., Hernandez‐Pineda, D., Banerjee, P., Matos, H. Y., Goodrich, M., Panigrahi, A. K., Smith, N., & Corbin, J. G. (2021) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2021.706079 · Cited by 12
D’Aniello, B., Mastellone, V., Pinelli, C., Scandurra, A., Musco, N., Tudisco, R., Pero, M. E., Infascelli, F., Lucrezia, A. D., & Lombardi, P. (2022) · Animals · doi:10.3390/ani12030276 · Cited by 12
Modulation of the thermosensory system by oxytocin
Zayan, U., Prato, L. C. D., Muscatelli, F., & Matarazzo, V. A. (2023) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.1075305 · Cited by 14
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Fujimoto, H., Liu, H.-X., Lopatina, O., Brown, D. A., & Higashida, H. (2013) · Neuroscience Letters · doi:10.1016/j.neulet.2013.04.059 · Cited by 12
Self-citationD’Errico, S., Borbone, N., Catalanotti, B., Secondo, A., Petrozziello, T., Piccialli, I., Pannaccione, A., Costantino, V., Mayol, L., Piccialli, G., et al. (2018) · Marine Drugs · doi:10.3390/md16030089 · Cited by 12
Handley, E. D., Warmingham, J. M., Rogosch, F. A., & Cicchetti, D. (2019) · Journal of Affective Disorders · doi:10.1016/j.jad.2019.06.051 · Cited by 14
COVID-19: Are We Facing Secondary Pellagra Which Cannot Simply Be Cured by Vitamin B3?
Kujundžić, R. N. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23084309 · Cited by 12
CD38 is Required for Dendritic Organization in Visual Cortex and Hippocampus
Nelissen, T. P., Bamford, R. A., Tochitani, S., Akkus, K., Kudzinskas, A., Yokoi, K., Okamoto, H., Yamamoto, Y., Burbach, J. P. H., Matsuzaki, H., et al. (2018) · Neuroscience · doi:10.1016/j.neuroscience.2017.12.050 · Cited by 14
Self-citationQuintana, D. S., Rokicki, J., van der Meer, D., Alnæs, D., Kaufmann, T., Córdova‐Palomera, A., Dieset, I., Andreassen, O. A., & Westlye, L. T. (2017) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/149526 · Cited by 12
Quintana, D. S. (2018) · OSF Preprints (OSF Preprints) · Cited by 12
Lémos, J. R. (2012) · Wiley eBooks · doi:10.1002/9780470015902.a0000176.pub2 · Cited by 12
The Neurobiology of Affiliation; Maternal-Infant Bonding to Life Within Social Groups
Feldman, R. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-819641-0.00058-x · Cited by 12
Yokoyama, S. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1197265 · Cited by 11
Self-citationMaejima, Y., Yokota, S., Hidema, S., Nishimori, K., de Wet, H., & Shimomura, K. (2024) · Neuroendocrinology · doi:10.1159/000538792 · Cited by 12
Sex differences in the effects of aromatherapy on anxiety and salivary oxytocin levels
Nakajima, D., Yamachi, M., Misaka, S., Shimomura, K., & Maejima, Y. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1380779 · Cited by 11
Kawasaki, M., Sakai, A., & Ueta, Y. (2024) · Peptides · doi:10.1016/j.peptides.2024.171263 · Cited by 11
Human social behavior and oxytocin: Molecular and neuronal mechanisms
Matsushita, H., & Nishiki, T. (2025) · Neuroscience · doi:10.1016/j.neuroscience.2025.02.026 · Cited by 11
Oxytocin and autism: Insights from clinical trials and animal models
Xing, C., & Yu, X. (2025) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2025.103015 · Cited by 11
Characteristics of cerebrospinal fluid in autism spectrum disorder – A systematic review
Srivastava, V., & O’Reilly, C. (2025) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2025.106202 · Cited by 11
The Neurobiology and Genetics of Affiliation and Social Bonding in Animal Models
Donaldson, Z. R., & Young, L. J. (2016) · Springer eBooks · doi:10.1007/978-1-4939-3777-6_4 · Cited by 12
Fu, P., Luo, S., Liu, Z., Furuhara, K., Tsuji, T., Higashida, H., Yokoyama, S., Zhong, J., & Tsuji, C. (2023) · Brain Sciences · doi:10.3390/brainsci13020316 · Cited by 11
Self-citationDudas, A., Nakahara, T. S., Pellissier, L. P., & Chamero, P. (2024) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105686 · Cited by 11
A Complicated Picture of Oxytocin Action in the Central Nervous System Revealed
Ring, R. H. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.03.020 · Cited by 11
Brain areas affected by intranasal oxytocin show higher oxytocin receptor expression
Habets, P. C., Mclain, C., & Meijer, O. C. (2021) · European Journal of Neuroscience · doi:10.1111/ejn.15447 · Cited by 11
Neurophysiological functions and pharmacological tools of acidic and non-acidic Ca2+ stores
Martucci, L. L., & Cancela, J. (2022) · Cell Calcium · doi:10.1016/j.ceca.2022.102582 · Cited by 11
Basic Research on Cerebellar Gene Therapy Using Lentiviral Vectors
Hirai, H. (2011) · The Cerebellum · doi:10.1007/s12311-011-0330-x · Cited by 11
Self-citationDevelopment of a highly specific enzyme immunoassay for oxytocin and its use in plasma samples
Haraya, S., Karasawa, K., Sano, Y., Ozawa, K., Kato, N., & Arakawa, H. (2016) · Annals of Clinical Biochemistry International Journal of Laboratory Medicine · doi:10.1177/0004563216645122 · Cited by 11
McInnis, O. A., McQuaid, R. J., Matheson, K., & Anisman, H. (2017) · Stress · doi:10.1080/10253890.2017.1286326 · Cited by 11
Zhang, L., Xu, X., Luo, Z., Shen, D., & Wu, H. (2008) · Biochimie · doi:10.1016/j.biochi.2008.09.003 · Cited by 10
Lagergren, K., Ek, W. E., Levine, D., Chow, W. H., Bernstein, L., Casson, A. G., Risch, H. A., Shaheen, N. J., Bird, N. C., Reid, B. J., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0138738 · Cited by 10
Dobewall, H., Saarinen, A. I. L., Lyytikäinen, L., Keltikangas‐Järvinen, L., Lehtimäki, T. J., & Hintsanen, M. (2021) · Frontiers in Psychology · doi:10.3389/fpsyg.2021.576346 · Cited by 13
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Tsukamoto, H., Olesen, N. D., Petersen, L. G., Suga, T., Sørensen, H., Nielsen, H. B., Ogoh, S., Secher, N. H., & Hashimoto, T. (2023) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000003360 · Cited by 10
Munk, A. J. L., Hermann, A., El‐Shazly, J., Grant, P. S., & Hennig, J. (2016) · PLoS ONE · doi:10.1371/journal.pone.0151991 · Cited by 11
Okamoto, H., Takasawa, S., & Yamamoto, Y. (2017) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2017.07.009 · Cited by 10
Self-citationRybicka, M., Kaźmierczak, M., Pawlicka, P., Łada‐Maśko, A., Anikiej‐Wiczenbach, P., & Bielawski, K. P. (2021) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2021.105294 · Cited by 10
Nominalism, realism and objectivity
Elgin, C. Z. (2016) · Synthese · doi:10.1007/s11229-016-1114-0 · Cited by 10
Cheong, R. Y., Tonetto, S., von Hörsten, S., & Petersén, Å. (2020) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2020.104773 · Cited by 11
Tapias-Espinosa, C., Cañete, T., Sampedro-Viana, D., Brudek, T., Kaihøj, A., Oliveras, I., Tobeña, A., Aznar, S., & Fernández‐Teruel, A. (2021) · Physiology & Behavior · doi:10.1016/j.physbeh.2021.113547 · Cited by 10
Pascut, D., Giraudi, P. J., Banfi, C., Ghilardi, S., Tiribelli, C., Bondesan, A., Caroli, D., Grugni, G., & Sartório, A. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13195697 · Cited by 9
Oliveras, I., Soria-Ruiz, O. J., Sampedro-Viana, D., Cañete, T., Tobeña, A., & Fernández‐Teruel, A. (2022) · Physiology & Behavior · doi:10.1016/j.physbeh.2022.113722 · Cited by 11
Chang, Y.-P., Way, B. M., Sheeran, P., Kurtz, L. E., Baucom, D. H., & Algoe, S. B. (2022) · Scientific Reports · doi:10.1038/s41598-022-15650-4 · Cited by 9
Paracrine ADP Ribosyl Cyclase-Mediated Regulation of Biological Processes
Astigiano, C., Benzi, A., Laugieri, M. E., Piacente, F., Sturla, L., Guida, L., Bruzzone, S., & FLORA, A. D. (2022) · Cells · doi:10.3390/cells11172637 · Cited by 9
Higashida, H., Oshima, Y., & Yamamoto, Y. (2024) · Peptides · doi:10.1016/j.peptides.2024.171230 · Cited by 10
Self-citationDeciphering autism heterogeneity: a molecular stratification approach in four mouse models
Gora, C., Dudas, A., Vaugrente, O., Drobecq, L., Pecnard, E., Lefort, G., & Pellissier, L. P. (2024) · Translational Psychiatry · doi:10.1038/s41398-024-03113-5 · Cited by 9
Epigenomic-Basis of Preemptive Medicine for Neurodevelopmental Disorders
Kubota, T., Miyake, K., Hariya, N., & Mochizuki, K. (2015) · Current Genomics · doi:10.2174/1389202916666150216221312 · Cited by 9
Vargas-Martínez, F., Schanler, R. J., Abrams, S. A., Hawthorne, K. M., Landers, S., Guzmán-Bárcenas, J., Muñoz, O., Henriksen, T., Petersson, M., Uvnäs‐Moberg, K., et al. (2016) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2016.09.020 · Cited by 9
Yang, X., Tang, Y., Wei, Q., Lang, B., Tao, H., Zhang, X., Liu, Y., & Tang, A. (2017) · Oncotarget · doi:10.18632/oncotarget.20252 · Cited by 9
Akahoshi, N., Handa, H., Takemoto, R., Kamata, S., Yoshida, M., Onaka, T., & Ishii, I. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20143507 · Cited by 9
Dual Nature of RAGE in Host Reaction and Nurturing the Mother–Infant Bond
Oshima, Y., Harashima, A., Munesue, S., Kimura, K., Leerach, N., Goto, H., Tanaka, M. H., Niimura, A., Hayashi, K., Yamamoto, H., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23042086 · Cited by 9
Self-citationNeuroendocrinology and Behavior
Sumiyoshi, T. (2012) · InTech eBooks · doi:10.5772/1666 · Cited by 9
Neumann, I. D., & van den Burg, E. H. (2013) · Cambridge University Press eBooks · doi:10.1017/cbo9781139017855.004 · Cited by 10
Custer, E. E., Knott, T., Ortiz‐Miranda, S., & Lémos, J. R. (2018) · Journal of Neuroendocrinology · doi:10.1111/jne.12605 · Cited by 9
Interactions Between the Neuroendocrine System and T Lymphocytes in Diabetes
Andreone, L., Gimeno, M. L., & Perone, M. J. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00229 · Cited by 9
Persico, A. M. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-397267-5.00045-5 · Cited by 9
Fisher, E. R., Rocha, N. P., Morales-Scheihing, D. A., Venna, V. R., Furr-Stimming, E. E., Teixeira, A. L., & Rossetti, M. A. (2021) · Journal of Huntington's disease · doi:10.3233/jhd-210467 · Cited by 8
Zhang, C.-Y., Zhu, X., Sun, W.-D., Bi, S.-Z., Lai, S.-Y., An-Liu, & Li, J.-H. (2025) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2025.110558 · Cited by 8
Maejima, Y., Yokota, S., Yamachi, M., Hidema, S., Ono, T., Taira, S., Nishimori, K., de Wet, H., & Shimomura, K. (2025) · Aging Cell · doi:10.1111/acel.70198 · Cited by 8
Reframing oxytocin as a behavioral flexibility hormone
Walle, K. M., Sartorius, A. M., Deilhaug, E., Kang, H., Nærland, T., Andreassen, O. A., Westlye, L. T., & Quintana, D. S. (2026) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2026.106628 · Cited by 10
Chong, A., Chew, S. H., Lai, P. S., Ebstein, R. P., & Gouin, J. (2018) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2018.02.015 · Cited by 8
Yang, J., Wang, C., Zhang, Y., Cheng, S., Wu, M., Gu, S., Xu, S., Wu, Y., Sheng, J., Voon, D. C., et al. (2023) · Cancer Cell International · doi:10.1186/s12935-023-03040-3 · Cited by 8
Takano, S., Tsuzuki, T., Murayama, T., Kameda, T., Kumaki, Y., Sakurai, T., Fukuda, H., Watanabe, M., Arisawa, M., & Shuto, S. (2017) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.7b00540 · Cited by 8
Khavari, B., Mahmoudi, E., Geaghan, M. P., & Cairns, M. J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21239182 · Cited by 8
Kunimi, Y., Minami, M., Muchanga, S. M. J., Eitoku, M., Hayashi, K., Fujieda, M., Suganuma, N., & Maeda, N. (2021) · Journal of Affective Disorders · doi:10.1016/j.jad.2021.11.058 · Cited by 8
Self-citationChronic Cocaine Exposure During Pregnancy Increases Postpartum Neuroendocrine Stress Responses
Williams, S. K., Barber, J. S., Jamieson‐Drake, A. W., Enns, J. A., Townsend, L. B., Walker, C. H., & Johns, J. M. (2012) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2012.02291.x · Cited by 8
Mahmuda, N. A., Yokoyama, S., Munesue, T., Hayashi, K., Yagi, K., Tsuji, C., & Higashida, H. (2020) · Diseases · doi:10.3390/diseases8010004 · Cited by 8
Self-citationSato, T., Watanabe, M., Tsuzuki, T., Takano, S., Murayama, T., Sakurai, T., Kameda, T., Fukuda, H., Arisawa, M., & Shuto, S. (2016) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.6b00437 · Cited by 8
Sun, J.-Y., Wang, Z., Xu, W., & Zhao, J. (2025) · Biochemical Pharmacology · doi:10.1016/j.bcp.2025.117050 · Cited by 8
Hirosawa, T., Kikuchi, M., Okumura, E., Yoshimura, Y., Hiraishi, H., Munesue, T., Takesaki, N., Furutani, N., Ono, Y., Higashida, H., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0116918 · Cited by 7
Self-citationMoridera, K., Uchida, S., Tanaka, S., Menuki, K., Utsunomiya, H., Yamaoka, K., Sonomoto, K., Tanaka, Y., & Sakai, A. (2019) · Journal of Orthopaedic Science · doi:10.1016/j.jos.2019.03.023 · Cited by 7
Self-citationHouldsworth, A. (2020) · MedEdPublish · doi:10.15694/mep.2020.000184.1 · Cited by 7
Sheng, W., Harden, S. W., Tan, Y., Krause, E. G., & Frazier, C. J. (2021) · eLife · doi:10.7554/elife.63486 · Cited by 7
A monoclonal antibody raised against a synthetic oxytocin peptide stains mouse hypothalamic neurones
Kogami, Y., Tsuji, T., Tsuji, C., Yokoyama, S., Furuhara, K., Lopatina, O. L., Shabalova, A. A., Salmina, A. B., Watanabe, Y., Hattori, T., et al. (2019) · Journal of Neuroendocrinology · doi:10.1111/jne.12815 · Cited by 7
Self-citationAbsence of M-Ras modulates social behavior in mice
Ehrhardt, A., Wang, B., Leung, M., & Schrader, J. W. (2015) · BMC Neuroscience · doi:10.1186/s12868-015-0209-8 · Cited by 7
Михайлович, Ч. С., Gerasimenko, M., Yuhi, T., Shabalova, A. A., Zhu, H., Yokoyama, S., Salmina, A. B., Munesue, S.-I., Harashima, A., Yamamoto, Y., et al. (2021) · Peptides · doi:10.1016/j.peptides.2021.170649 · Cited by 7
Self-citationSeshadri, A. J., & Hayashi‐Takagi, A. (2009) · Progress in brain research · doi:10.1016/s0079-6123(09)17903-7 · Cited by 7
Oxytocin facilitates human touch-induced play behavior in rats
Hayashi, H., Tateishi, S., Inutsuka, A., Maejima, S., Hagiwara, D., Sakuma, Y., Onaka, T., Grinevich, V., & Sakamoto, H. (2025) · Current Biology · doi:10.1016/j.cub.2025.05.034 · Cited by 6
Variability in the expression and perception of positive affect in human infancy
Großmann, T., & Wood, A. (2023) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsad049 · Cited by 6
Wakuda, T., Benner, S., Uemura, Y., Nishimura, T., Kojima, M., Kuroda, M., Matsumoto, K., Kanai, C., Inada, N., Harada, T., et al. (2024) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2024.03.013 · Cited by 6
Self-citationNeuropeptides affecting social behavior in mammals: Oxytocin
Zhou, H., Zhu, R., Xia, Y., Zhang, X., Wang, Z., Lorimer, G. H., Ghiladi, R. A., Bayram, H., & Wang, J. (2024) · Peptides · doi:10.1016/j.peptides.2024.171223 · Cited by 6
The Signaling Protein CD38 Is Essential for Early Embryonic Development
Churamani, D., Geach, T. J., Ramakrishnan, L., Prideaux, N., Patel, S., & Dale, L. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.c111.323618 · Cited by 6
Seervai, R. N. H., Friske, S. K., Chu, E. Y., Phillips, R. M., Nelson, K. C., Huen, A., Cho, W. C., Aung, P. P., Torres-Cabala, C. A., Prieto, V. G., et al. (2022) · Journal of Cutaneous Pathology · doi:10.1111/cup.14327 · Cited by 6
Camerini, L., Zurchimitten, G., Bock, B. B., Xavier, J., Bastos, C. R., Martins, E., Ardais, A. P., Motta, J. V. D. S., Pires, A. J., de Matos, M. B., et al. (2022) · Child Psychiatry & Human Development · doi:10.1007/s10578-022-01419-3 · Cited by 6
Walker, M. A. (2008) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.12.8.949 · Cited by 6
Hara‐Yokoyama, M., Kimura, T., Kaku, H., Wakiyama, M., Kaitsu, Y., Inoue, M., Kusano, S., Shirouzu, M., Yokoyama, S., Katada, T., et al. (2007) · International Immunopharmacology · doi:10.1016/j.intimp.2007.10.010 · Cited by 6
Self-citationHigashida, H., Kamimura, S.-Y., Inoue, T., Hori, O., Islam, M. S., Lopatina, O. L., & Tsuji, C. (2016) · Journal of Neural Transmission · doi:10.1007/s00702-016-1666-7 · Cited by 6
Self-citationPurinergic receptor types in the hypothalamic‐neurohypophysial system
Lémos, J. R., Custer, E. E., & Ortiz‐Miranda, S. (2018) · Journal of Neuroendocrinology · doi:10.1111/jne.12588 · Cited by 6
Михайлович, Ч. С., Miura, R., Shabalova, A. A., Ichinose, W., Yokoyama, S., Fukuda, H., Watanabe, M., Higashida, H., & Shuto, S. (2019) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2019.06.018 · Cited by 6
Self-citationLemche, E. (2020) · acta ethologica · doi:10.1007/s10211-020-00346-7 · Cited by 6
Experience-Regulated Neuronal Signaling in Maternal Behavior
Fuentes, I., Morishita, Y., González-Salinas, S., Champagne, F. A., Uchida, S., & Shumyatsky, G. P. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.844295 · Cited by 8
ATF6β Deficiency Elicits Anxiety-like Behavior and Hyperactivity Under Stress Conditions
Tanaka, T., Nguyen, D. T., Kwankaew, N., Sumizono, M., Shinoda, R., Ishii, H., Takarada‐Iemata, M., Hattori, T., Oyadomari, S., Kato, N., et al. (2023) · Neurochemical Research · doi:10.1007/s11064-023-03900-4 · Cited by 6
Yonekura, H., Kato, I., Yamamoto, Y., Ikeda, T., Higashida, H., & Okamoto, H. (2023) · Endocrinology · doi:10.1210/endocr/bqad121 · Cited by 6
Self-citationTereshchenko, S. Y., & Smolnikova, M. V. (2019) · S S Korsakov Journal of Neurology and Psychiatry · doi:10.17116/jnevro2019119121148 · Cited by 6
Takasawa, S., Makino, M., Uchiyama, T., Yamauchi, A., Sakuramoto‐Tsuchida, S., Itaya‐Hironaka, A., Takeda, Y., Asai, K., Shobatake, R., & Ota, H. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23158782 · Cited by 6
Self-citationKudoh, T., Murayama, T., Hashii, M., Higashida, H., Sakurai, T., Maechling, C., Spiess, B., Weber, K., Guse, A. H., Potter, B. V. L., et al. (2008) · Tetrahedron · doi:10.1016/j.tet.2008.07.068 · Cited by 6
Self-citationTom, N., & Assinder, S. J. (2010) · BioMolecular Concepts · doi:10.1515/bmc.2010.036 · Cited by 7
Khani, P., Dezfouli, M. A., Nasri, F., Rahemi, M., Ahmadloo, S., Afkhami, H., Saeidi, F., Tereshchenko, S. Y., Bigdeli, M. R., & Modarressi, M. H. (2023) · Frontiers in Genetics · doi:10.3389/fgene.2023.1002048 · Cited by 8
Metadata
- Authors
- Jin, D., Liu, H.-X., Hirai, H., Torashima, T., Nagai, T., Lopatina, O., Shnayder, N. A., Yamada, K., Noda, M., Seike, T., Fujita, K., Takasawa, S., Yokoyama, S., Koizumi, K., Shiraishi, Y., Tanaka, S., Hashii, M., Yoshihara, T., Higashida, K., Islam, M. S., Yamada, N., Hayashi, K., Noguchi, N., Kato, I., Okamoto, H., Matsushima, A., Salmina, A., Munesue, T., Shimizu, N., Mochida, S., Asano, M., & Higashida, H.
- Affiliations
- Kanazawa University (JP)
- Kyushu University (JP)
- University of Toyama (JP)
- Tohoku University (JP)
- Nanao hospital (JP)
- Krasnoyarsk State Medical University (RU)
- Kanazawa University Hospital (JP)
- Tokyo Medical University (JP)
- Corresponding author
- Hirai, Hirokazu
- Higashida, Haruhiro
- ORCID
- Venue
- Nature
- Published
- 2007-02-07
- Volume
- 446
- Issue
- 7131
- Pages
- 41-45
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2048596172
- Cited by
- 665
- References
- 44
- Citations by year
- 2026: 11 · 2025: 19 · 2024: 34 · 2023: 26 · 2022: 30 · 2021: 44 · 2020: 47 · 2019: 31 · 2018: 34 · 2017: 53 · 2016: 40 · 2015: 42 · 2014: 45 · 2013: 39 · 2012: 36
- FWCI
- 41.65
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- CD38, oxytocin secretion, social behavior, maternal behavior, ADP-ribosyl cyclase, neuropeptide release, neuroendocrine regulation, hypothalamus, neurohypophysis, calcium signaling, CD38 knockout mice, social memory, neurodevelopmental disorders
- MeSH terms
- Amnesia, Animals, Calcium, Female, Gene Expression Regulation, Humans, Injections, Male, Maternal Behavior, Memory, Motor Activity, Oxytocin, Social Behavior, Vasopressins, Calcium Signaling, Mice, ADP-ribosyl Cyclase 1
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