The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
CD38 is critical for social behaviour by regulating oxytocin secretion
Abstract
CD38, a transmembrane glycoprotein with ADP-ribosyl cyclase activity, catalyses the formation of Ca2+ signalling molecules, but its role in the neuroendocrine system is unknown. Here we show that adult CD38 knockout (CD38-/-) female and male mice show marked defects in maternal nurturing and social behaviour, respectively, with higher locomotor activity. Consistently, the plasma level of oxytocin (OT), but not vasopressin, was strongly decreased in CD38-/- mice. Replacement of OT by subcutaneous injection or lentiviral-vector-mediated delivery of human CD38 in the hypothalamus rescued social memory and maternal care in CD38-/- mice. Depolarization-induced OT secretion and Ca2+ elevation in oxytocinergic neurohypophysial axon terminals were disrupted in CD38-/- mice; this was mimicked by CD38 metabolite antagonists in CD38+/+ mice. These results reveal that CD38 has a key role in neuropeptide release, thereby critically regulating maternal and social behaviours, and may be an element in neurodevelopmental disorders.
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In the citing paper
“A seminal study showed that OTR and D2 receptor activation must occur concurrently for partner preference to develop in female prairie voles [66].”
From Oxytocin and the Neural Mechanisms Regulating Social Cognition and Affiliative Behavior (2009) · cites this paper as [66]
In the citing paper
“In addition, research has pointed to the central role of transmembrane glycoprotein CD38 in OT neuropathways and in the release of OT from axon terminalis (Jin et al., 2007), and recent findings showed associations between plasma OT, genetic variability in the CD38 rs3796863 SNP, and the degree of reciprocity and touch between parents and their infants (Feldman et al., in press), pointing to the”
From Oxytocin during the initial stages of romantic attachment: Relations to couples’ interactive reciprocity (2012) · cites this paper as Jin et al., 2007
In the citing paper
“Blockade of D2 receptors in the NAcc shell prevented OT-mediated partner preferences, while blockade of OTR in the NAcc shell prevented D2 receptor mediated partner preferences in female prairie voles.”
From Oxytocin and the Neural Mechanisms Regulating Social Cognition and Affiliative Behavior (2009) · cites this paper as [66]
In the citing paper
“Blockade of D2 receptors in the NAcc shell prevented OT-mediated partner preferences,”
From Oxytocin and the Neural Mechanisms Regulating Social Cognition and Affiliative Behavior (2009) · cites this paper as [66]
In the citing paper
“Blockade of D2 receptors in the NAcc shell prevented OT-mediated partner preferences, while blockade of OTR in the NAcc shell prevented D2 receptor mediated partner preferences in female prairie voles.”
From Oxytocin and the Neural Mechanisms Regulating Social Cognition and Affiliative Behavior (2009) · cites this paper as [66]
In the citing paper
“CD38 catalyzes the synthesis of the Ca2+-responsive messenger cyclic ADP-ribose (cADPR) by use of NAD+ and plays a key role in multiple physiological processes such as immunity, metabolism, inflammation, and even social behaviors (Jin et al., 2007).”
From NAD+ in Brain Aging and Neurodegenerative Disorders (2019) · cites this paper as Jin et al., 2007
In the citing paper
“CD38 was also reported to affect social behaviour, as was its homologue CD157 (REFS166,167)”
From NAD+ metabolism and its roles in cellular processes during ageing (2021) · cites this paper as [166]
In the citing paper
“Mice with impaired OT release or signalling display impairments in maternal responsiveness (3,4).”
From Comparative Perspectives on Oxytocin and Vasopressin Receptor Research in Rodents and Primates: Translational Implications (2016) · cites this paper as [3]
In the citing paper
“The role of the OXT system has been investigated in rodent models, but uniquely using OXT-related mutant mice and giving OXT through intracerebroventricular (ICV), intraperitoneal (IP) and subcutaneous (SC) injections (Bielsky and Young, 2004;Jin et al, 2007;Popik et al, 1996;Sala et al, 2012;Sala et al, 2011;Takayanagi et al, 2005;Winslow and Insel, 2002).”
From Chronic and acute intranasal oxytocin produce divergent social effects in mice (2014) · cites this paper as Jin et al, 2007
In the citing paper
“Specifically, CD38 is involved in oxytocin secretion via Ca2+ release15”
From Oxytocin pathway gene networks in the human brain (2019) · cites this paper as [15]
In the citing paper
“Normal maternal behaviour is restored by peripheral oxcytocin replacement in Oxt−/− and Cd38−/−, but not Oxtr−/− mice, implying that circulating oxcytocin crosses the blood-brain barrier.”
From Vascular RAGE transports oxytocin into the brain to elicit its maternal bonding behaviour in mice (2019) · cites this paper as [5]
In the citing paper
“Loss of maternal nurturing and social interactive behaviours in Cd38−/− mice have been restored following peripheral administration of oxytocin, consistent with transport of peripherally administered exogenous oxytocin into brain5.”
From Vascular RAGE transports oxytocin into the brain to elicit its maternal bonding behaviour in mice (2019) · cites this paper as [5]
In the citing paper
“Compared to placebo, oxytocin administered to eight adolescent and adult males with FXS significantly increased overall eye gaze during a brief social interaction.59 Interestingly, lower doses of oxytocin in this sample appeared to show a greater effect than the higher administered dose, consistent with a recent study in healthy adults.60”
From Beyond the hype and hope: critical considerations for intranasal oxytocin research in autism spectrum disorder (2017) · cites this paper as [60]
In the citing paper
“recent investigations into dose-dependent effects of oxytocin on social cognition have demonstrated superior effects at lower (8 IU) doses.60”
From Beyond the hype and hope: critical considerations for intranasal oxytocin research in autism spectrum disorder (2017) · cites this paper as [60]
In the citing paper
“Initial evidence suggests that lower dose (8IU) oxytocin delivered via this device is effective in modulating aspects of emotional behaviour.60”
From Beyond the hype and hope: critical considerations for intranasal oxytocin research in autism spectrum disorder (2017) · cites this paper as [60]
In the citing paper
“In comparison with wild-type mice, CD38 -/-mice have reduced OXT levels in the plasma and cerebrospinal fluid (CSF) (Jin et al., 2007) but elevated levels in the hypothalamus and pituitary tissues.”
From CD38 and its role in oxytocin secretion and social behavior (2012) · cites this paper as Jin et al., 2007
In the citing paper
“It is also required for normal social behavior in mice (Jin et al., 2007).”
From CD38 and its role in oxytocin secretion and social behavior (2012) · cites this paper as Jin et al., 2007
In the citing paper
“We have recently shown that CD38 is required, as shown by the decreased formation of cADPR and by CICR, for some social behaviors in mice via the regulation of OXT secretion from the hypothalamus and pituitary (Jin et al., 2007;Higashida et al., 2010;Salmina et al., 2010).”
From CD38 and its role in oxytocin secretion and social behavior (2012) · cites this paper as Jin et al., 2007
In the citing paper
“We used a genetic approach to re-express CD38 by infusing a virus carrying the human CD38 gene into the third ventricle of knockout mice.This procedure resulted in the normalization of the plasma and CSF OXT levels, thereby normalizing social memory (see Fig. 2 of Jin et al., 2007).”
From CD38 and its role in oxytocin secretion and social behavior (2012) · cites this paper as Jin et al., 2007
In the citing paper
“In addition, social amnesia was not rescued by the local expression of human R140W-CD38, via a lentiviral infection, in the hypothalamus of CD38 knockout mice (Fig. 2 of Jin et al., 2007).”
From CD38 and its role in oxytocin secretion and social behavior (2012) · cites this paper as Jin et al., 2007
In the citing paper
“The behavioral phenotype of CD38 -/-mice could be normalized by a single subcutaneous OXT injection because OXT is able to enter into the brain, probably through the blood-brain barrier (see Supplementary Fig. S7 of Jin et al., 2007).”
From CD38 and its role in oxytocin secretion and social behavior (2012) · cites this paper as Jin et al., 2007
In the citing paper
“In contrast, CD38 -/-males showed sustained high levels of investigation at every encounter with the same female (Jin et al., 2007).”
From CD38 and its role in oxytocin secretion and social behavior (2012) · cites this paper as Jin et al., 2007
In the citing paper
“These results suggested that CD38 may have an important role in OT release in the human hypothalamus, as in the mice (Jin et al., 2007;Liu et al., 2008).”
From Two genetic variants of CD38 in subjects with autism spectrum disorder and controls (2010) · cites this paper as Jin et al., 2007
In the citing paper
“They showed that CD38 regulates OT secretion in the mouse hypothalamus and posterior pituitary, which is critical for mouse social behavior (Jin et al., 2007;Liu et al., 2008).”
From Two genetic variants of CD38 in subjects with autism spectrum disorder and controls (2010) · cites this paper as Jin et al., 2007
In the citing paper
“Moreover, social amnesia was not rescued by local re-expression of human W140-CD38 in the hypothalamus in the Cd38 null mice (Jin et al., 2007).”
From Two genetic variants of CD38 in subjects with autism spectrum disorder and controls (2010) · cites this paper as Jin et al., 2007
Citations
Cites
Oxytocin increases trust in humans
Kosfeld, M., Heinrichs, M., Zak, P. J., Fischbacher, U., & Fehr, E. (2005) · Nature · doi:10.1038/nature03701 · Cited by 3,690
Cognitive neuroscience of emotional memory
LaBar, K. S., & Cabeza, R. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1825 · Cited by 1,834
Oxytocin Modulates Neural Circuitry for Social Cognition and Fear in Humans
Kirsch, P., Esslinger, C., Chen, Q., Mier, D., Lis, S., Siddhanti, S., Gruppe, H., Mattay, V. S., Gallhofer, B., & Meyer-Lindenberg, A. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.3984-05.2005 · Cited by 1,639
The neurobiology of pair bonding.
Young, L. J., & Wang, Z. (2004) · Nature Neuroscience · doi:10.1038/nn1327 · Cited by 1,523
The neural correlates of maternal and romantic love
Bartels, A., & Zeki, S. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2003.11.003 · Cited by 1,497
The neurobiology of attachment
Insel, T. R., & Young, L. J. (2001) · Nature Reviews Neuroscience · doi:10.1038/35053579 · Cited by 1,173
Social amnesia in mice lacking the oxytocin gene
Ferguson, J. N., Young, L. J., Hearn, E. F., Matzuk, M. M., Insel, T. R., & Winslow, J. T. (2000) · Nature Genetics · doi:10.1038/77040 · Cited by 1,130
Dendritic peptide release and peptide-dependent behaviours
Ludwig, M., & Leng, G. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1845 · Cited by 945
Pervasive social deficits, but normal parturition, in oxytocin receptor-deficient mice
Takayanagi, Y., Yoshida, M., Bielsky, I. F., Ross, H. E., Kawamata, M., Onaka, T., Yanagisawa, T., Kimura, T., Matzuk, M. M., Young, L. J., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0505312102 · Cited by 806
Formation and Hydrolysis of Cyclic ADP-Ribose Catalyzed by Lymphocyte Antigen CD38
Howard, M., Grimaldi, J. C., Bazán, J. F., Lund, F. E., Santos‐Argumedo, L., Parkhouse, R. M. E., Walseth, T. F., & Lee, H. C. (1993) · Science · doi:10.1126/science.8235624 · Cited by 737
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Gul, R., Kim, S.-Y., Park, K., Kim, B.-J., Kim, S.-J., Im, M., & Kim, U. (2008) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01355.2007 · Cited by 49
Glezer, I., Bittencourt, J. C., & Rivest, S. (2009) · The Journal of Comparative Neurology · doi:10.1002/cne.22185 · Cited by 49
Oxytocin—a social peptide? Deconstructing the evidence
Leng, G., Leng, R., & Ludwig, M. (2022) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2021.0055 · Cited by 51
Avraham, Y., Berry, E. M., Donskoy, M., Ahmad, W. A., Vorobiev, L., Albeck, A., & Mankuta, D. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.09.041 · Cited by 48
Role of oxytocin in parental behaviour
Olazábal, D. E. (2018) · Journal of Neuroendocrinology · doi:10.1111/jne.12594 · Cited by 49
Sauer, C., Montag, C., Reuter, M., & Kirsch, P. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2013.00045 · Cited by 49
Lopatina, O. L., Ивановна, И. А., Пичугина, Ю. А., Okamoto, H., Salmina, A. B., & Higashida, H. (2011) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2011.02136.x · Cited by 48
Self-citationZhang, X., He, T., Wu, Z., Wang, Y., Liu, H., Zhang, B., Yang, S., Wang, D., Huang, C., Duan, J., et al. (2023) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2023.09.026 · Cited by 46
Self-citationModulation/physiology of calcium channel sub-types in neurosecretory terminals
Lémos, J. R., Ortiz‐Miranda, S., Cuadra, A. E., Velázquez‐Marrero, C., Custer, E. E., Dad, T., & Dayanithi, G. (2012) · Cell Calcium · doi:10.1016/j.ceca.2012.01.008 · Cited by 46
Higashida, H., Furuhara, K., Yamauchi, A.-M., Deguchi, K., Harashima, A., Munesue, S., Lopatina, O. L., Gerasimenko, M., Salmina, A. B., Zhang, J., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-07949-4 · Cited by 46
Self-citationMacbeth, A. H., Edds, J. S., & Young, W. S. (2009) · Nature Protocols · doi:10.1038/nprot.2009.141 · Cited by 46
Muscatelli, F., Desarménien, M. G., Matarazzo, V. A., & Grinevich, V. (2017) · Current topics in behavioral neurosciences · doi:10.1007/7854_2017_16 · Cited by 48
Covalent and Noncovalent Intermediates of an NAD Utilizing Enzyme, Human CD38
Liu, Q., Kriksunov, I. A., Jiang, H., Graeff, R. M., Lin, H., Lee, H. C., & Hao, Q. (2008) · Chemistry & Biology · doi:10.1016/j.chembiol.2008.08.007 · Cited by 45
Lopatina, O. L., Liu, H.-X., Amina, S., Hashii, M., & Higashida, H. (2009) · Neuropharmacology · doi:10.1016/j.neuropharm.2009.06.012 · Cited by 45
Self-citationKiss, I., Levy‐Gigi, E., & Kéri, S. (2011) · Biological Psychology · doi:10.1016/j.biopsycho.2011.08.005 · Cited by 45
The link between autism spectrum disorder and gut microbiota: A scoping review
Nitschke, A. S., Deonandan, R., & Konkle, A. T. M. (2020) · Autism · doi:10.1177/1362361320913364 · Cited by 46
Factors that contribute to the maintenance or decline of relationship satisfaction
Righetti, F., Faure, R., Zoppolat, G., Meltzer, A. L., & McNulty, J. K. (2022) · Nature Reviews Psychology · doi:10.1038/s44159-022-00026-2 · Cited by 48
Chang, S.-C., Glymour, M. M., Rewak, M., Cornelis, M. C., Walter, S., Koenen, K. C., Kawachi, I. I., Liang, L., Tchetgen, E. J. T., & Kubzansky, L. D. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.09.024 · Cited by 47
Ruan, Q., Ruan, J., Zhang, W., Qian, F., & Yu, Z. (2017) · Pharmacological Research · doi:10.1016/j.phrs.2017.08.010 · Cited by 44
Boslett, J., Reddy, N., Alzarie, Y. A., & Zweier, J. L. (2019) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.118.254557 · Cited by 43
Mizuno, A., Михайлович, Ч. С., Kikuchi, Y., Fakhrul, A. A. K. M., Akther, S., Deguchi, K., Yoshihara, T., Ishihara, K., Shuto, S., & Higashida, H. (2015) · Brain Sciences · doi:10.3390/brainsci5010003 · Cited by 43
Self-citationZhong, J., Amina, S., Liang, M., Akther, S., Yuhi, T., Nishimura, T., Tsuji, C., Tsuji, T., Liu, H.-X., Hashii, M., et al. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00304 · Cited by 42
Self-citationAkther, S., Fakhrul, A. A. K. M., & Higashida, H. (2014) · Neuroscience Letters · doi:10.1016/j.neulet.2014.03.078 · Cited by 42
Self-citationLee, H. C., Deng, Q. W., & Zhao, Y. J. (2021) · Cell Calcium · doi:10.1016/j.ceca.2021.102514 · Cited by 42
Haram, M., Tesli, M., Bettella, F., Djurovic, S., Andreassen, O. A., & Melle, I. S. (2015) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2015.00009 · Cited by 43
Ma, W.-J., Hashii, M., Munesue, T., Hayashi, K., Yagi, K., Yamagishi, M., Higashida, H., & Yokoyama, S. (2013) · Molecular Autism · doi:10.1186/2040-2392-4-22 · Cited by 46
Self-citationAbnormal behaviours relevant to neurodevelopmental disorders in Kirrel3-knockout mice
Hisaoka, T., Komori, T., Kitamura, T., & Morikawa, Y. (2018) · Scientific Reports · doi:10.1038/s41598-018-19844-7 · Cited by 45
Seeley, S. H., Chou, Y., & O'Connor, M. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.09.011 · Cited by 43
Common variant in OXTR predicts growth in positive emotions from loving-kindness training
Isgett, S. F., Algoe, S. B., Boulton, A. J., Way, B. M., & Fredrickson, B. L. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.08.010 · Cited by 41
McQuaid, R. J., McInnis, O. A., Matheson, K., & Anisman, H. (2016) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2016.00358 · Cited by 42
Stohn, J. P., Martinez, M. E., Zafer, M., López-Espíndola, D., Keyes, L. M., & Hernández, A. (2017) · Genes Brain & Behavior · doi:10.1111/gbb.12400 · Cited by 41
Ma, Y., Cao, W. J., Wang, L., Jiang, J., Nie, H., Wang, B., Wei, X., & Ying, W. (2014) · Glia · doi:10.1002/glia.22651 · Cited by 40
Vaisitti, T., Audrito, V., Serra, S., Buonincontri, R., Sociali, G., Mannino, E., Pagnani, A., Zucchetto, A., Tissino, E., Vitale, C., et al. (2014) · Leukemia · doi:10.1038/leu.2014.207 · Cited by 40
Nyffeler, J., Walitza, S., Bobrowski, E., Gundelfinger, R., & Grünblatt, E. (2014) · Journal of Molecular Psychiatry · doi:10.1186/2049-9256-2-1 · Cited by 43
The ADP-ribosyl cyclases - the current evolutionary state of the ARCs
Enza, M. F. (2014) · Frontiers in bioscience · doi:10.2741/4262 · Cited by 40
Gerasimenko, M., Михайлович, Ч. С., Furuhara, K., Lopatina, O. L., Salmina, A. B., Shabalova, A. A., Tsuji, C., Yokoyama, S., Ishihara, K., Brenner, C., et al. (2020) · Scientific Reports · doi:10.1038/s41598-019-57236-7 · Cited by 40
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Horenstein, A. L., Faini, A. C., Morandi, F., Bracci, C., Lanza, F., Giuliani, N., Paulus, A., & Malavasi, F. (2020) · Molecules · doi:10.3390/molecules25204844 · Cited by 41
Missing and Possible Link between Neuroendocrine Factors, Neuropsychiatric Disorders, and Microglia
Kato, T. A., Hayakawa, K., Monji, A., & Kanba, S. (2013) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2013.00053 · Cited by 43
Manto, M. U., & Marmolino, D. (2009) · The Cerebellum · doi:10.1007/s12311-009-0127-3 · Cited by 40
Quintana, D. S., Dieset, I., Elvsåshagen, T., Westlye, L. T., & Andreassen, O. A. (2017) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2016.12.004 · Cited by 39
Yuhi, T., Ise, K., Iwashina, K., Terao, N., Yoshioka, S., Shomura, K., Maehara, T., Yazaki, A., Koichi, K., Furuhara, K., et al. (2018) · Behavioral Sciences · doi:10.3390/bs8110101 · Cited by 39
Self-citationA Novel Role of CD38 and Oxytocin as Tandem Molecular Moderators of Human Social Behavior
Tolomeo, S., Chiao, B., Lei, Z., Chew, S. H., & Ebstein, R. P. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.04.013 · Cited by 40
Oxytocin Signaling Pathway: From Cell Biology to Clinical Implications
Iovino, M., Messana, T., Tortora, A., Giusti, C., Lisco, G., Giagulli, V. A., Guastamacchia, E., Pergola, G. D., & Triggiani, V. (2020) · Endocrine Metabolic & Immune Disorders - Drug Targets · doi:10.2174/1871530320666200520093730 · Cited by 39
Zhong, J., Liang, M., Akther, S., Higashida, C., Tsuji, T., & Higashida, H. (2014) · Molecular Brain · doi:10.1186/s13041-014-0066-x · Cited by 38
Self-citationParticipatory Art Activities Increase Salivary Oxytocin Secretion of ASD Children
Tanaka, S., Komagome, A., Iguchi-Sherry, A., Nagasaka, A., Yuhi, T., Higashida, H., Rooksby, M., Kikuchi, M., Arai, O., Minami, K., et al. (2020) · Brain Sciences · doi:10.3390/brainsci10100680 · Cited by 38
Self-citationThe Role of Intranasal Oxytocin in the Treatment of Patients with Schizophrenia: A Systematic Review
Berardis, D. D., Marini, S., Iasevoli, F., Tomasetti, C., de Bartolomeis, A., Mazza, M., Valchera, A., Fornaro, M., Cavuto, M., Srinivasan, V., et al. (2013) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527311312020012 · Cited by 39
Shiraishi, M., Matsuzaki, M., Kurihara, S., Iwamoto, M., & Shimada, M. (2020) · BMC Pregnancy and Childbirth · doi:10.1186/s12884-020-03431-8 · Cited by 38
CD38 regulates oxytocin secretion and complex social behavior
Bartz, J. A., & McInnes, L. A. (2007) · BioEssays · doi:10.1002/bies.20623 · Cited by 39
Tabak, B. A., Vrshek‐Schallhorn, S., Zinbarg, R. E., Prenoveau, J. M., Mineka, S., Redei, E. E., Adam, E. K., & Craske, M. G. (2015) · Clinical Psychological Science · doi:10.1177/2167702615577470 · Cited by 38
Associations between oxytocin-related genes and autistic-like traits
Hovey, D., Zettergren, A., Jonsson, L., Melke, J., Anckarsäter, H., Lichtenstein, P., & Westberg, L. (2014) · Social Neuroscience · doi:10.1080/17470919.2014.897995 · Cited by 37
Design, synthesis and biological characterization of novel inhibitors of CD38
Dong, M., Si, Y.-Q., Sun, S.-Y., Pu, X., Yang, Z.-J., Zhang, L., Zhang, L., Leung, F. P., Lam, C. M. C., Kwong, A. K., et al. (2011) · Organic & Biomolecular Chemistry · doi:10.1039/c0ob00768d · Cited by 37
Metabolic aspects of neuronal degeneration: From a NAD+ point of view
Sasaki, Y. (2018) · Neuroscience Research · doi:10.1016/j.neures.2018.07.001 · Cited by 39
Shen, M., Guo, Y., Dong, Q., Gao, Y., Stockton, M. E., Li, M., Kannan, S., Korabelnikov, T., Schoeller, K. A., Sirois, C. L., et al. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01096-z · Cited by 38
Hara‐Yokoyama, M., Kukimoto‐Niino, M., Terasawa, K., Harumiya, S., Podyma‐Inoue, K. A., Hino, N., Sakamoto, K., Itoh, S., Hashii, N., Hiruta, Y., et al. (2012) · Structure · doi:10.1016/j.str.2012.06.017 · Cited by 37
Self-citationChen, D., Zhao, J.-H., Wang, H., An, N., Zhou, Y., Fan, J., Luo, J., Su, W., Liu, C., & Li, J. (2015) · Scientific Reports · doi:10.1038/srep11731 · Cited by 37
Oxytocin: The Neuropeptide of Love Reveals Some of Its Secrets
Neumann, I. D. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.03.008 · Cited by 37
Salmina, A. B., Lopatina, O., Ekimova, M. V., Mikhutkina, S. V., & Higashida, H. (2010) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2010.01970.x · Cited by 36
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Wagner, S., & Harony‐Nicolas, H. (2017) · Current topics in behavioral neurosciences · doi:10.1007/7854_2017_15 · Cited by 39
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Faulkes, C. G., & Bennett, N. C. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-65943-1_1 · Cited by 39
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Eapen, V. (2011) · InTech eBooks · doi:10.5772/974 · Cited by 36
Imamura, Y., Morita, S., Nakatani, Y., Okada, K., Ueshima, S., Matsuo, O., & Miyata, S. (2010) · Journal of Neuroscience Research · doi:10.1002/jnr.22370 · Cited by 36
Kim, S., & Strathearn, L. (2017) · The Psychoanalytic Study of the Child · doi:10.1080/00797308.2016.1277897 · Cited by 38
Althammer, F., Jirikowski, G. F., & Grinevich, V. (2018) · Peptides · doi:10.1016/j.peptides.2018.09.003 · Cited by 35
Zhang, K., Sun, W., Huang, L., Zhu, K., Pei, F., Zhu, L., Wang, Q., Lü, Y., Zhang, H., Jin, H., et al. (2016) · Journal of the American Chemical Society · doi:10.1021/jacs.6b08088 · Cited by 35
Cirnigliaro, M., Barbagallo, C., Gulisano, M., Domini, C., Barone, R. M. E., Barbagallo, D., Ragusa, M., Pietro, C. D., Rizzo, R., & Purrello, M. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00250 · Cited by 35
Ceroni, F., Sagar, A., Simpson, N. H., Gawthrope, A. J. T., Newbury, D. F., Pinto, D., Francis, S. M., Tessman, D. C., Cook, E. H., Monaco, A. P., et al. (2014) · Autism Research · doi:10.1002/aur.1365 · Cited by 34
Mechanism-Based Small Molecule Probes for Labeling CD38 on Live Cells
Jiang, H., Congleton, J., Liu, Q., Merchant, P., Malavasi, F., Lee, H. C., Hao, Q., Yen, A., & Lin, H. (2009) · Journal of the American Chemical Society · doi:10.1021/ja808387g · Cited by 34
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Funaro, A. (2009) · Frontiers in bioscience · doi:10.2741/3287 · Cited by 33
Regulating the Social Brain: A New Role for CD38
Young, L. J. (2007) · Neuron · doi:10.1016/j.neuron.2007.04.011 · Cited by 33
Progress in transduction of cerebellar Purkinje cells in vivo using viral vectors
Hirai, H. (2008) · The Cerebellum · doi:10.1007/s12311-008-0012-5 · Cited by 33
Self-citationYuhi, T., Kyuta, H., Mori, H.-A., Murakami, C., Furuhara, K., Okuno, M., Takahashi, M., Fuji, D., & Higashida, H. (2017) · Brain Sciences · doi:10.3390/brainsci7110152 · Cited by 32
Self-citationIs Oxytocin Application for Autism Spectrum Disorder Evidence-Based?
Lee, S. Y., Lee, A. R., Hwangbo, R., Han, J., Hong, M., & Bahn, G. H. (2015) · Experimental Neurobiology · doi:10.5607/en.2015.24.4.312 · Cited by 33
Iwasa, T., Matsuzaki, T., Mayila, Y., Yanagihara, R., Yamamoto, Y., Kawakita, T., Kuwahara, A., & Irahara, M. (2019) · Neuropeptides · doi:10.1016/j.npep.2019.03.002 · Cited by 33
Munesue, S., Liang, M., Harashima, A., Zhong, J., Furuhara, K., Boitsova, E. B., Михайлович, Ч. С., Gerasimenko, M., Yuhi, T., Yamamoto, Y., et al. (2021) · Journal of Neuroendocrinology · doi:10.1111/jne.12963 · Cited by 32
Self-citationDesign, Synthesis and SAR Studies of NAD Analogues as Potent Inhibitors towards CD38 NADase
Wang, S., Zhu, W., Wang, X., Li, J., Zhang, K., Zhang, L., Zhao, Y. J., Lee, H., & Zhang, L. (2014) · Molecules · doi:10.3390/molecules191015754 · Cited by 32
Catalysis-Based Inhibitors of the Calcium Signaling Function of CD38
Kwong, A. K., Chen, Z., Zhang, H., Leung, F. P., Lam, C. M. C., Ting, K. Y., Zhang, L., Hao, Q., Zhang, L., & Lee, H. C. (2011) · Biochemistry · doi:10.1021/bi201509f · Cited by 32
TNB-738, a biparatopic antibody, boosts intracellular NAD+ by inhibiting CD38 ecto-enzyme activity
Ugamraj, H. S., Dang, K. H., Ouisse, L., Buelow, B., Chini, E. N., Castello, G., Allison, J., Clarke, S., Davison, L. M., Buelow, R., et al. (2022) · mAbs · doi:10.1080/19420862.2022.2095949 · Cited by 31
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Ebstein, R. P., Mankuta, D., Yirmiya, N., & Malavasi, F. (2011) · FEBS Letters · doi:10.1016/j.febslet.2011.05.004 · Cited by 32
Uruno, A., Noguchi, N., Matsuda, K., Nata, K., Yoshikawa, T., Chikamatsu, Y., Kagechika, H., Harigae, H., Ito, S., Okamoto, H., et al. (2011) · Journal of Leukocyte Biology · doi:10.1189/jlb.0109025 · Cited by 31
Self-citationLopatina, O. L., Furuhara, K., Ishihara, K., Salmina, A. B., & Higashida, H. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00266 · Cited by 30
Self-citationInvestigating cADPR and NAADP in intact and broken cell preparations
Morgan, A. J., & Galione, A. (2008) · Methods · doi:10.1016/j.ymeth.2008.09.013 · Cited by 30
Ichinose, W., Михайлович, Ч. С., Shabalova, A. A., Yokoyama, S., Yuhi, T., Yamaguchi, H., Watanabe, A., Yamamoto, Y., Okamoto, H., Horike, S., et al. (2019) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.8b01691 · Cited by 30
Self-citationZhao, Y. J., Zhang, H. M., Lam, C. M. C., Hao, Q., & Lee, H. C. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.228379 · Cited by 30
CD38 and bone marrow microenvironment
Chillemi, A. (2014) · Frontiers in bioscience · doi:10.2741/4201 · Cited by 30
Ectoenzymes in leukocyte migration and their therapeutic potential
Salmi, M., & Jalkanen, S. (2014) · Seminars in Immunopathology · doi:10.1007/s00281-014-0417-9 · Cited by 30
Li, J., You, Y., Yue, W., Jia, M., Yu, H., Lu, T., Wu, Z., Ruan, Y., Wang, L., & Zhang, D. (2015) · PLoS ONE · doi:10.1371/journal.pone.0142887 · Cited by 30
Denda, S., Kumamoto, J., Takei, K., Tsutsumi, M., Aoki, H., & Denda, M. (2011) · Journal of Investigative Dermatology · doi:10.1038/jid.2011.256 · Cited by 30
Association Study between the CD157/BST1 Gene and Autism Spectrum Disorders in a Japanese Population
Yokoyama, S., Mahmuda, N. A., Munesue, T., Hayashi, K., Yagi, K., Yamagishi, M., & Higashida, H. (2015) · Brain Sciences · doi:10.3390/brainsci5020188 · Cited by 29
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Martucci, L. L., Amar, M., Chaussenot, R., Benet, G., Bauer, O., de Zélicourt, A., Nosjean, A., Launay, J., Callebert, J., Sebrié, C., et al. (2019) · The FASEB Journal · doi:10.1096/fj.201800489r · Cited by 30
CD38 regulates ovarian function and fecundity via NAD+ metabolism
Perrone, R., Kumaar, P. V. A., Haky, L., Hahn, C., Riley, R. R., Balough, J. L., Zaza, G., Soygur, B., Hung, K., Prado, L., et al. (2023) · iScience · doi:10.1016/j.isci.2023.107949 · Cited by 30
Gross Margolis, K., Vittorio, J., Talavera, M., Gluck, K., Li, Z., Iuga, A., Stevanovic, K., Saurman, V., Israelyan, N., Welch, M. G., et al. (2017) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00215.2017 · Cited by 28
The hidden life of NAD+-consuming ectoenzymes in the endocrine system
Malavasi, F., Deaglio, S., Zaccarello, G., Horenstein, A. L., Chillemi, A., Audrito, V., Serra, S., Gandione, M., Zitella, A., & Tizzani, A. (2010) · Journal of Molecular Endocrinology · doi:10.1677/jme-10-0082 · Cited by 28
Orexin action on oxytocin neurons in the paraventricular nucleus of the hypothalamus
Maejima, Y., Takahashi, S., Takasu, K., Takenoshita, S., Ueta, Y., & Shimomura, K. (2017) · Neuroreport · doi:10.1097/wnr.0000000000000773 · Cited by 28
Shi, Y., Li, S., Zhang, H., Zhu, J., Che, T., Yan, B., Li, J., & Liu, C. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02313-w · Cited by 28
Huang, M., Liu, K., Wei, Z., Feng, Z., Chen, J., Yang, J., Zhong, Q., Wan, G., & Kong, X. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.721884 · Cited by 28
CD38 Plays a Dual Role in Allergen-Induced Airway Hyperresponsiveness
Gally, F., Hartney, J. M., Janssen, W. J., & Perraud, A. (2008) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2007-0392oc · Cited by 28
Zhang, X., Li, L., Zhang, Q., Wei, Q., Lin, J., Jia, J., Zhang, J., Yan, T., Lv, Y., Jiang, X., et al. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00191 · Cited by 28
NAD metabolism in aging and cancer
Kincaid, J. W. R., & Berger, N. A. (2020) · Experimental Biology and Medicine · doi:10.1177/1535370220929287 · Cited by 29
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Takasawa, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23084306 · Cited by 29
Self-citationInhibition of ADP-ribosyl cyclase attenuates angiotensin II-induced cardiac hypertrophy
Gul, R., Park, J., Kim, S.-Y., Jang, K. Y., Chae, J.-K., Ko, J.-K., & Kim, U. (2008) · Cardiovascular Research · doi:10.1093/cvr/cvn232 · Cited by 27
Metadata
- Authors
- Jin, D., Liu, H.-X., Hirai, H., Torashima, T., Nagai, T., Lopatina, O., Shnayder, N. A., Yamada, K., Noda, M., Seike, T., Fujita, K., Takasawa, S., Yokoyama, S., Koizumi, K., Shiraishi, Y., Tanaka, S., Hashii, M., Yoshihara, T., Higashida, K., Islam, M. S., Yamada, N., Hayashi, K., Noguchi, N., Kato, I., Okamoto, H., Matsushima, A., Salmina, A., Munesue, T., Shimizu, N., Mochida, S., Asano, M., & Higashida, H.
- Affiliations
- Kanazawa University (JP)
- Kyushu University (JP)
- University of Toyama (JP)
- Tohoku University (JP)
- Nanao hospital (JP)
- Krasnoyarsk State Medical University (RU)
- Kanazawa University Hospital (JP)
- Tokyo Medical University (JP)
- Corresponding author
- Hirai, Hirokazu
- Higashida, Haruhiro
- ORCID
- Venue
- Nature
- Published
- 2007-02-07
- Volume
- 446
- Issue
- 7131
- Pages
- 41-45
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2048596172
- Cited by
- 665
- References
- 44
- Citations by year
- 2026: 11 · 2025: 19 · 2024: 34 · 2023: 26 · 2022: 30 · 2021: 44 · 2020: 47 · 2019: 31 · 2018: 34 · 2017: 53 · 2016: 40 · 2015: 42 · 2014: 45 · 2013: 39 · 2012: 36
- FWCI
- 41.65
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- CD38, oxytocin secretion, social behavior, maternal behavior, ADP-ribosyl cyclase, neuropeptide release, neuroendocrine regulation, hypothalamus, neurohypophysis, calcium signaling, CD38 knockout mice, social memory, neurodevelopmental disorders
- MeSH terms
- Amnesia, Animals, Calcium, Female, Gene Expression Regulation, Humans, Injections, Male, Maternal Behavior, Memory, Motor Activity, Oxytocin, Social Behavior, Vasopressins, Calcium Signaling, Mice, ADP-ribosyl Cyclase 1
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