Oxytocin signal and social behaviour: comparison among adult and infant oxytocin, oxytocin receptor and CD38 gene knockout mice
Open accessAbstract
Oxytocin in the hypothalamus is the biological basis of social recognition, trust, love and bonding. Previously, we showed that CD38, a proliferation marker in leukaemia cells, plays an important role in the hypothalamus in the process of oxytocin release in adult mice. Disruption of Cd38 (Cd38 (-/-)) elicited impairment of maternal behaviour and male social recognition in adult mice, similar to the behaviour observed in Oxt and oxytocin receptor (Oxtr) gene knockout (Oxt (-/-) and Oxtr (-/-), respectively) mice. Locomotor activity induced by separation from the dam was higher and the number of ultrasonic vocalisation calls was lower in Cd38 (-/-) than Cd38( +/+) pups. However, these behavioural changes were much milder than those observed in Oxt (-/-) and Oxtr (-/-) mice, indicating less impairment of social behaviour in Cd38 (-/-) pups. These phenotypes appeared to be caused by the high plasma oxytocin levels during development from the neonatal period to 3-week-old juvenile mice. ADP-ribosyl cyclase activity was markedly lower in the knockout mice from birth, suggesting that weaning for mice is a critical time window of plasma oxytocin differentiation. Breastfeeding was an important exogenous source of plasma oxytocin regulation before weaning as a result of the presence of oxytocin in milk and the dam's mammary glands. The dissimilarity between Cd38 (-/-) infant behaviour and those of Oxt (-/-) or Oxtr (-/-) mice can be explained partly by this exogenous source of oxytocin. These results suggest that secretion of oxytocin into the brain in a CD38-dependent manner may play an important role in the development of social behaviour.
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CD38 is required for some social behaviors in mice via the regulation of OXT secretion from the hypothalamus and pituitary.
“We have recently shown that CD38 is required, as shown by the decreased formation of cADPR and by CICR, for some social behaviors in mice via the regulation of OXT secretion from the hypothalamus and pituitary (Jin et al., 2007;Higashida et al., 2010;Salmina et al., 2010).”
From CD38 and its role in oxytocin secretion and social behavior (2012) · cites this paper as Higashida et al., 2010
ADP-ribosyl cyclase activity in the hypothalamus is significantly higher in CD38 +/+ than in CD38 -/- mice from the second week of life onward.
“CD38 +/+ mice showed significantly higher levels of ADP-ribosyl cyclase activity in the hypothalamus from the second week of life onward, and the difference in comparison with CD38 -/-mice increased markedly (Higashida et al., 2010).”
From CD38 and its role in oxytocin secretion and social behavior (2012) · cites this paper as Higashida et al., 2010
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- Authors
- Higashida, H., Lopatina, O., Yoshihara, T., Pichugina, Y. A., Soumarokov, A. A., Munesue, T., Minabe, Y., Kikuchi, M., Ono, Y., Korshunova, N., & Salmina, A. B.
- Affiliations
- Kanazawa University (JP)
- Krasnoyarsk State Medical University (RU)
- Corresponding author
- Higashida, H.
- Venue
- Journal of Neuroendocrinology
- Publisher
- Wiley
- Published
- 2010-04-19
- Volume
- 22
- Issue
- 5
- Pages
- 373-379
- ISSN
- 0953-8194 (ISSN-L)
- 1365-2826
- OpenAlex
- W1969024362
- Cited by
- 98
- References
- 51
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 2 · 2023: 4 · 2022: 3 · 2021: 7 · 2020: 5 · 2019: 6 · 2018: 8 · 2017: 4 · 2016: 4 · 2015: 10 · 2014: 8 · 2013: 8 · 2012: 12
- FWCI
- 13.99
- Type
- journal article
- Language
- en
- Open access
- Licence
- Locations
- Journal of Neuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- Institutional Repositories DataBase (IRDB) (submittedVersion, cc-by-nc-nd)
- Kanazawa University Repository for Academic Resources (DSpace) (Kanazawa University) (submittedVersion, cc-by-nc-nd)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Human-Animal Interaction Studies
- Keywords
- oxytocin, CD38, ADP-ribosyl cyclase, oxytocin receptor, hypothalamus, social behavior, maternal behavior, social recognition, ultrasonic vocalizations, weaning, breastfeeding, plasma oxytocin, knockout mice, infant development
- MeSH terms
- Animals, Central Nervous System, Female, Locomotion, Male, Oxytocin, Social Behavior, Signal Transduction, Receptors, Oxytocin, ADP-ribosyl Cyclase, Mice, ADP-ribosyl Cyclase 1
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