Chitin induces accumulation in tissue of innate immune cells associated with allergy

Alternative activation of macrophages

Gordon, S. (2003) · Nature Reviews Immunology · doi:10.1038/nri978 · Cited by 6,189

Exploring the full spectrum of macrophage activation

Mosser, D. M., & Edwards, J. P. (2008) · Nature Reviews Immunology · doi:10.1038/nri2448 · Cited by 9,144

Macrophage plasticity and polarization: in vivo veritas

Sica, A., & Mantovani, A. (2012) · Journal of Clinical Investigation · doi:10.1172/jci59643 · Cited by 6,335

Protective and pathogenic functions of macrophage subsets

Murray, P. J., & Wynn, T. A. (2011) · Nature Reviews Immunology · doi:10.1038/nri3073 · Cited by 5,269

Alternative activation of macrophages: mechanism and functions

Gordon, S., & Martinez, F. O. (2010) · Immunity · doi:10.1016/j.immuni.2010.05.007 · Cited by 4,197

Recognition of microorganisms and activation of the immune response

Medzhitov, R. (2007) · Nature · doi:10.1038/nature06246 · Cited by 2,862

Overview of the immune response

Chaplin, D. D. (2010) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2009.12.980 · Cited by 2,235

The Fungal Cell Wall: Structure, Biosynthesis, and Function

Gow, N. A. R., Latge, J.-P., & Munro, C. A. (2017) · Microbiology Spectrum · doi:10.1128/microbiolspec.funk-0035-2016 · Cited by 1,423

Macrophages: master regulators of inflammation and fibrosis

Wynn, T., & Barron, L. (2010) · Seminars in Liver Disease · doi:10.1055/s-0030-1255354 · Cited by 1,392

The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection

Satoh, T., Takeuchi, O., Vandenbon, A., Yasuda, K., Tanaka, Y., Kumagai, Y., Miyake, T., Matsushita, K., Okazaki, T., Saitoh, T., et al. (2010) · Nature Immunology · doi:10.1038/ni.1920 · Cited by 1,156

Type 2 immunity in tissue repair and fibrosis

Gieseck, R. L., Wilson, M. S., & Wynn, T. A. (2018) · Nature Reviews Immunology · doi:10.1038/nri.2017.90 · Cited by 1,055

An integrated model of the recognition of Candida albicans by the innate immune system

Netea, M. G., Brown, G. D., Kullberg, B. J., & Gow, N. A. R. (2008) · Nature Reviews Microbiology · doi:10.1038/nrmicro1815 · Cited by 946

Role of Chitin and Chitinase/Chitinase-Like Proteins in Inflammation, Tissue Remodeling, and Injury

Lee, C. G., Da Silva, C. A., Dela Cruz, C. S., Ahangari, F., Ma, B., Kang, M.-J., He, C.-H., Takyar, S., & Elias, J. A. (2011) · Annual Review of Physiology · doi:10.1146/annurev-physiol-012110-142250 · Cited by 896

Towards an understanding of the adjuvant action of aluminium

Marrack, P., McKee, A. S., & Munks, M. W. (2009) · Nature Reviews Immunology · doi:10.1038/nri2510 · Cited by 887

Type 2 Innate Signals Stimulate Fibro/Adipogenic Progenitors to Facilitate Muscle Regeneration

Heredia, J. E., Mukundan, L., Chen, F. M., Mueller, A. A., Deo, R. C., Locksley, R. M., Rando, T. A., & Chawla, A. (2013) · Cell · doi:10.1016/j.cell.2013.02.053 · Cited by 818

Arginase-1–Expressing Macrophages Suppress Th2 Cytokine–Driven Inflammation and Fibrosis

Pesce, J. T., Ramalingam, T. R., Mentink-Kane, M. M., Wilson, M. S., El Kasmi, K. C., Smith, A. M., Thompson, R. W., Cheever, A. W., Murray, P. J., & Wynn, T. A. (2009) · PLoS Pathogens · doi:10.1371/journal.ppat.1000371 · Cited by 816

Protective immune mechanisms in helminth infection

Anthony, R. M., Rutitzky, L. I., Urban, J. F., Stadecker, M. J., & Gause, W. C. (2007) · Nature Reviews Immunology · doi:10.1038/nri2199 · Cited by 779

Current views on fungal chitin/chitosan, human chitinases, food preservation, glucans, pectins and inulin: A tribute to Henri Braconnot, precursor of the carbohydrate polymers science, on the chitin bicentennial

Muzzarelli, R. A. A., Boudrant, J., Meyer, D., Manno, N., DeMarchis, M., & Paoletti, M. G. (2012) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2011.09.063 · Cited by 694

Tolerance and M2 (alternative) macrophage polarization are related processes orchestrated by p50 nuclear factor κB

Porta, C., Rimoldi, M., Raes, G., Brys, L., Ghezzi, P., Di Liberto, D., Dieli, F., Ghisletti, S., Natoli, G., De Baetselier, P., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0809784106 · Cited by 627

Control of Macrophage Activation and Function by PPARs

Chawla, A. (2010) · Circulation Research · doi:10.1161/circresaha.110.216523 · Cited by 531

Chitin synthesis and fungal pathogenesis

Lenardon, M. D., Munro, C. A., & Gow, N. A. (2010) · Current Opinion in Microbiology · doi:10.1016/j.mib.2010.05.002 · Cited by 502

C-type lectin receptors orchestrate antifungal immunity

Hardison, S. E., & Brown, G. D. (2012) · Nature Immunology · doi:10.1038/ni.2369 · Cited by 460

Allergic host defences

Palm, N. W., Rosenstein, R. K., & Medzhitov, R. (2012) · Nature · doi:10.1038/nature11047 · Cited by 352

Importance of the Candida albicans cell wall during commensalism and infection

Gow, N. A., & Hube, B. (2012) · Current Opinion in Microbiology · doi:10.1016/j.mib.2012.04.005 · Cited by 347

Fibrosis is regulated by Th2 and Th17 responses and by dynamic interactions between fibroblasts and macrophages

Barron, L., & Wynn, T. A. (2011) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00414.2010 · Cited by 304

Alternatively activated macrophages in helminth infections

Kreider, T., Anthony, R. M., Urban, J. F., & Gause, W. C. (2007) · Current Opinion in Immunology · doi:10.1016/j.coi.2007.07.002 · Cited by 304

Alternative activation is an innate response to injury that requires CD4+ T cells to be sustained during chronic infection

Loke, P., Gallagher, I., Nair, M. G., Zang, X., Brombacher, F., Mohrs, M., Allison, J. P., & Allen, J. E. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.6.3926 · Cited by 274

Chitin activates parallel immune modules that direct distinct inflammatory responses via innate lymphoid type 2 and γδ T cells

Van Dyken, S. J., Mohapatra, A., Nussbaum, J. C., Molofsky, A. B., Thornton, E. E., Ziegler, S. F., McKenzie, A. N. J., Krummel, M. F., Liang, H.-E., & Locksley, R. M. (2014) · Immunity · doi:10.1016/j.immuni.2014.02.003 · Cited by 251

Chitin Recognition via Chitotriosidase Promotes Pathologic Type-2 Helper T Cell Responses to Cryptococcal Infection

Wiesner, D. L., Specht, C. A., Lee, C. K., Smith, K. D., Mukaremera, L., Lee, S. T., Lee, C. G., Elias, J. A., Nielsen, J. N., Boulware, D. R., et al. (2015) · PLOS Pathogens · doi:10.1371/journal.ppat.1004701 · Cited by 214

Proteins induced by telomere dysfunction and DNA damage represent biomarkers of human aging and disease

Jiang, H., Schiffer, E., Song, Z., Wang, J., Zürbig, P., Thedieck, K., Moes, S., Bantel, H., Saal, N., Jantos, J., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0801457105 · Cited by 169

The m6A Reader IGF2BP2 Regulates Macrophage Phenotypic Activation and Inflammatory Diseases by Stabilizing TSC1 and PPAR γ

Wang, X., Ji, Y., Feng, P., Liu, R., Li, G., Zheng, J., Xue, Y., Wei, Y., Ji, C., Chen, D., et al. (2021) · Advanced Science · doi:10.1002/advs.202100209 · Cited by 147

The role of chitin detection in plant–pathogen interactions

Kombrink, A., Sánchez-Vallet, A., & Thomma, B. P. H. J. (2011) · Microbes and Infection · doi:10.1016/j.micinf.2011.07.010 · Cited by 121

Alternatively Activated Macrophages in Intestinal Helminth Infection: Effects on Concurrent Bacterial Colitis

Weng, M., Huntley, D., Huang, I.-F., Foye-Jackson, O., Wang, L., Sarkissian, A., Zhou, Q., Walker, W. A., Cherayil, B. J., & Shi, H. N. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.7.4721 · Cited by 116

ARG1-expressing microglia show a distinct molecular signature and modulate postnatal development and function of the mouse brain

Stratoulias, V., Ruiz, R., Kanatani, S., Osman, A. M., Keane, L., Armengol, J. A., Rodríguez-Moreno, A., Murgoci, A.-N., García-Domínguez, I., Alonso-Bellido, I., et al. (2023) · Nature Neuroscience · doi:10.1038/s41593-023-01326-3 · Cited by 96

Chitinases and chitinase-like proteins as biomarkers in neurologic disorders

Pinteac, R., Montalban, X., & Comabella, M. (2021) · Neurology Neuroimmunology & Neuroinflammation · doi:10.1212/nxi.0000000000000921 · Cited by 87

Pattern recognition pathways leading to a Th2 cytokine bias in allergic bronchopulmonary aspergillosis patients

Becker, K. L., Gresnigt, M. S., Smeekens, S. P., Jacobs, C. W., Magis‐Escurra, C., Jaeger, M., Wang, X., Lubbers, R., Oosting, M., Joosten, L. A. B., et al. (2015) · Clinical & Experimental Allergy · doi:10.1111/cea.12354 · Cited by 83

Keeping track of the growing number of biological functions of chitin and its interaction partners in biomedical research

Koch, B. E., Stougaard, J., & Spaink, H. P. (2015) · Glycobiology · doi:10.1093/glycob/cwv005 · Cited by 72

Aspergillus Cell Wall Chitin Induces Anti- and Proinflammatory Cytokines in Human PBMCs via the Fc-γ Receptor/Syk/PI3K Pathway

Becker, K. L., Aimanianda, V., Wang, X., Gresnigt, M. S., Ammerdorffer, A., Jacobs, C. W., Gazendam, R. P., Joosten, L. A. B., Netea, M. G., Latgé, J. P., et al. (2016) · mBio · doi:10.1128/mbio.01823-15 · Cited by 73

Polarization of host immune responses by helminth‐expressed glycans

Tundup, S., Srivastava, L., & Harn, Jr. (2012) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2012.06618.x · Cited by 71

Innate immunostimulatory properties of allergens and their relevance to food allergy

Ruiter, B., & Shreffler, W. G. (2012) · Seminars in Immunopathology · doi:10.1007/s00281-012-0334-8 · Cited by 47

Immune and genetic aspects of asthma, allergy and parasitic worm infections: evolutionary links

HOPKIN, J. (2009) · Parasite Immunology · doi:10.1111/j.1365-3024.2009.01104.x · Cited by 35

Immune responses to airborne fungi and non-invasive airway diseases

Vacher, G., Niculita-Hirzel, H., & Roger, T. (2015) · Seminars in Immunopathology · doi:10.1007/s00281-014-0471-3 · Cited by 33

Effect of antibiotic use and mold exposure in infancy on allergic rhinitis in susceptible adolescents

Yang, S.-I., Lee, E., Jung, Y.-H., Kim, H. Y., Seo, J.-H., Kwon, J.-W., Kim, B.-J., Kim, H.-B., Lee, S.-Y., Jang, G. C., et al. (2014) · Annals of Allergy, Asthma & Immunology · doi:10.1016/j.anai.2014.05.019 · Cited by 29

Assessment of Environmental Cockroach Allergen Exposure

Chew, G. L. (2012) · Current Allergy and Asthma Reports · doi:10.1007/s11882-012-0287-y · Cited by 17

Hypoxia Sensing in Resident Cardiac Macrophages Regulates the Arg1 Macrophage Lineage During Ischemic Heart Injury

Kadyrov, F. F., Koenig, A. L., Amrute, J. M., Dun, H., Li, W., Weinheimer, C. J., Nigro, J. M., Kovacs, A., Bredemeyer, A. L., Lai, L., et al. (2022) · doi:10.1101/2022.08.04.502542 · Cited by 3