Delayed ageing through damage protection by the Arf/p53 pathway

Structure, mechanism and regulation of peroxiredoxins

Wood, Z. A., Schröder, E., Harris, J. R., & Poole, L. B. (2003) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(02)00003-8 · Cited by 2,546

p53 in health and disease

Vousden, K. H., & Lane, D. P. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2147 · Cited by 2,351

Statistical analysis of real-time PCR data

Yuan, J. S., Reed, A., Chen, F., & Stewart, C. N. (2006) · BMC Bioinformatics · doi:10.1186/1471-2105-7-85 · Cited by 2,231

The p53 pathway: positive and negative feedback loops

Harris, S. L., & Levine, A. J. (2005) · Oncogene · doi:10.1038/sj.onc.1208615 · Cited by 1,967

Extension of murine life span by overexpression of catalase targeted to mitochondria

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p53 mutant mice that display early ageing-associated phenotypes

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Intrinsic tumour suppression

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The antioxidant function of the p53 tumor suppressor

Sablina, A. A., Budanov, A. V., Ilyinskaya, G. V., Agapova, L. S., Kravchenko, J. E., & Chumakov, P. M. (2005) · Nature Medicine · doi:10.1038/nm1320 · Cited by 1,137

Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a

Janzen, V., Forkert, R., Fleming, H. E., Saito, Y., Waring, M. T., Dombkowski, D. M., Cheng, T., DePinho, R. A., Sharpless, N. E., & Scadden, D. T. (2006) · Nature · doi:10.1038/nature05159 · Cited by 1,106

Cellular Senescence in Aging Primates

Herbig, U., Ferreira, M., Condel, L., Carey, D., & Sedivy, J. M. (2006) · Science · doi:10.1126/science.1122446 · Cited by 1,101

TXNIP maintains the hematopoietic cell pool by switching the function of p53 under oxidative stress

Jung, H., Kim, M. J., Kim, D. O., Kim, W. S., Yoon, S.-J., Park, Y.-J., Yoon, S. R., Kim, T.-D., Suh, H.-W., Yun, S., et al. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.06.002 · Cited by 132

Small extracellular vesicles from young adipose-derived stem cells prevent frailty, improve health span, and decrease epigenetic age in old mice

Sanz-Ros, J., Romero-García, N., Mas-Bargues, C., Monleón, D., Gordevicius, J., Brooke, R. T., Dromant, M., Díaz, A., Derevyanko, A., Guío-Carrión, A., et al. (2022) · Science Advances · doi:10.1126/sciadv.abq2226 · Cited by 131

p21 Both Attenuates and Drives Senescence and Aging in BubR1 Progeroid Mice

Baker, D. J., Weaver, R. L., & van Deursen, J. M. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.03.028 · Cited by 130

Biology of Cancer and Aging: A Complex Association With Cellular Senescence

Falandry, C., Bonnefoy, M., Freyer, G., & Gilson, É. (2014) · Journal of Clinical Oncology · doi:10.1200/jco.2014.55.1432 · Cited by 133

The regulation of p53 by phosphorylation: a model for how distinct signals integrate into the p53 pathway

MacLaine, N. J., & Hupp, T. R. (2009) · Aging · doi:10.18632/aging.100047 · Cited by 134

The Arf/p53 Pathway in Cancer and Aging

Matheu, A., Maraver, A., & Serrano, M. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-6851 · Cited by 132

The role of p53 in cell metabolism

Zhang, X., Qin, Z.-H., & Wang, J. (2010) · Acta Pharmacologica Sinica · doi:10.1038/aps.2010.151 · Cited by 135

Genetic inactivation of Cdk7 leads to cell cycle arrest and induces premature aging due to adult stem cell exhaustion

Ganuza, M., Sáiz-Ladera, C., Cañamero, M., Goméz-López, G., Schneider, R. P., Blasco, M. A., Pisano, D. G., Paramio, J. M., Santamarı́a, D., & Barbacid, M. (2012) · The EMBO Journal · doi:10.1038/emboj.2012.94 · Cited by 131

Heightened uterine mammalian target of rapamycin complex 1 (mTORC1) signaling provokes preterm birth in mice

Hirota, Y., Cha, J., Yoshie, M., Daikoku, T., & Dey, S. K. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1108180108 · Cited by 125

Sestrin2 prevents age‐related intolerance to ischemia and reperfusion injury by modulating substrate metabolism

Quan, N., Sun, W., Wang, L., Xu, C., Bogan, J. S., Zhou, X., Cates, C. A., Liu, Q., Zheng, Y., & Li, J. (2017) · The FASEB Journal · doi:10.1096/fj.201700063r · Cited by 124

MicroRNA Regulation of Oxidative Stress‐Induced Cellular Senescence

Bu, H., Wedel, S., Cavinato, M. S., & Jansen‐Dürr, P. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/2398696 · Cited by 127

Nuclear DNA Damage as a Direct Cause of Aging

Best, B. P. (2009) · Rejuvenation Research · doi:10.1089/rej.2009.0847 · Cited by 129

Targeting the “hallmarks of aging” to slow aging and treat age-related disease: fact or fiction?

Keshavarz, M., Xie, K., Schaaf, K., Bano, D., & Ehninger, D. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01680-x · Cited by 130

Requirement of the ATM/p53 Tumor Suppressor Pathway for Glucose Homeostasis

Armata, H. L., Golebiowski, D., Jung, D. Y., Ko, H. J., Kim, J. K., & Sluss, H. K. (2010) · Molecular and Cellular Biology · doi:10.1128/mcb.00347-10 · Cited by 121

Systemic DNA damage responses in aging and diseases

Ribezzo, F., Shiloh, Y., & Schumacher, B. (2016) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2015.12.005 · Cited by 116

Puma is required for p53-induced depletion of adult stem cells

Liu, D., Ou, L. Y., Clemenson, G. D., Chao, C., Lutske, M. E., Zambetti, G. P., Gage, F. H., & Xu, Y. (2010) · Nature Cell Biology · doi:10.1038/ncb2100 · Cited by 114

Mouse Models to Disentangle the Hallmarks of Human Aging

Folgueras, A. R., Freitas-Rodríguez, S., Velasco, G., & López-Otín, C. (2018) · Circulation Research · doi:10.1161/circresaha.118.312204 · Cited by 113

Cellular senescence: Its role in tumor suppression and aging

Ohtani, N., Mann, D. J., & Hara, E. (2009) · Cancer Science · doi:10.1111/j.1349-7006.2009.01123.x · Cited by 119

p53/CEP‐1 increases or decreases lifespan, depending on level of mitochondrial bioenergetic stress

Ventura, N., Rea, S. L., Schiavi, A., Torgovnick, A., Testi, R., & Johnson, T. E. (2009) · Aging Cell · doi:10.1111/j.1474-9726.2009.00482.x · Cited by 114

Single-gene mutations and healthy ageing in mammals

Bartke, A. (2010) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2010.0281 · Cited by 110

Exercise: the lifelong supplement for healthy ageing and slowing down the onset of frailty

Viña, J., Rodríguez‐Mañas, L., Salvador‐Pascual, A., Tarazona‐Santabalbina, F. J., & Gómez‐Cabrera, M. C. (2016) · The Journal of Physiology · doi:10.1113/jp270536 · Cited by 113

New plays in the p53 theater

Aylon, Y., & Oren, M. (2011) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2010.10.002 · Cited by 106

Anti‐aging activity of the Ink4/Arf locus

Matheu, A., Maraver, A., Collado, M., Garcia‐Cao, I., Cañamero, M., Borras, C., Flores, J. M., Klatt, P., Viña, J., & Serrano, M. (2009) · Aging Cell · doi:10.1111/j.1474-9726.2009.00458.x · Cited by 94

Xanthine oxidase-induced oxidative stress causes activation of NF-κB and inflammation in the liver of type I diabetic rats

Romagnoli, M., Gómez‐Cabrera, M. C., Perrelli, M.-G., Biasi, F., Pallardó, F. V., Sastre, J., Poli, G., & Viña, J. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.03.024 · Cited by 106

PML is a ROS sensor activating p53 upon oxidative stress

Niwa-Kawakita, M., Ferhi, O., Soilihi, H., Le Bras, M., Lallemand-Breitenbach, V., & de Thé, H. (2017) · Journal of Experimental Medicine · doi:10.1084/jem.20160301 · Cited by 104

Tissue regenerative delays and synthetic lethality in adult mice after combined deletion of Atr and Trp53

Ruzankina, Y., Schoppy, D. W., Asare, A., Clark, C. E., Vonderheide, R. H., & Brown, E. J. (2009) · Nature Genetics · doi:10.1038/ng.441 · Cited by 97

p53 deletion impairs clearance of chromosomal-instable stem cells in aging telomere-dysfunctional mice

Begus-Nahrmann, Y., Lechel, A., Obenauf, A. C., Nalapareddy, K., Peit, E., Hoffmann, E., Schlaudraff, F., Liss, B., Schirmacher, P., Kestler, H., et al. (2009) · Nature Genetics · doi:10.1038/ng.426 · Cited by 88

Life-long spontaneous exercise does not prolong lifespan but improves health span in mice

Garcia-Valles, R., Gómez‐Cabrera, M. C., Rodríguez‐Mañas, L., García‐García, F. J., Díaz, A., Noguera, I., González, G. O., & Viña, J. (2013) · Longevity & Healthspan · doi:10.1186/2046-2395-2-14 · Cited by 107

Does Damage to DNA and Other Macromolecules Play a Role in Aging? If So, How?

Campisi, J., & Vijg, J. (2009) · The Journals of Gerontology Series A · doi:10.1093/gerona/gln065 · Cited by 104

The uric acid transporter SLC2A9 is a direct target gene of the tumor suppressor p53 contributing to antioxidant defense

Itahana, Y., Han, R., Barbier, S., Lei, Z., Rozen, S., & Itahana, K. (2014) · Oncogene · doi:10.1038/onc.2014.119 · Cited by 102

Yeast-like chronological senescence in mammalian cells: phenomenon, mechanism and pharmacological suppression

Leontieva, O. V., & Blagosklonny, M. V. (2011) · Aging · doi:10.18632/aging.100402 · Cited by 101

Ink4‐Arf locus in cancer and aging

Sherr, C. J. (2012) · Wiley Interdisciplinary Reviews Developmental Biology · doi:10.1002/wdev.40 · Cited by 104

Signaling networks in aging

Greer, E. L., & Brunet, A. (2008) · Journal of Cell Science · doi:10.1242/jcs.021519 · Cited by 102

Cellular life span and the Warburg effect

Kondoh, H. (2008) · Experimental Cell Research · doi:10.1016/j.yexcr.2008.03.007 · Cited by 98

A free radical theory of frailty

Viña, J., Borrás, C., & Gómez‐Cabrera, M. C. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.06.028 · Cited by 97

p53 at the crossroads between cancer and neurodegeneration

Lanni, C., Racchi, M., Memo, M., Govoni, S., & Uberti, D. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.02.034 · Cited by 95

p53/MDM2 signaling pathway in aging, senescence and tumorigenesis

Huang, Y., Che, X., Wang, P., & Qu, X. (2024) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2024.05.001 · Cited by 99

Biological mechanisms of aging predict age-related disease co-occurrence in patients

Fraser, H. C., Kuan, V., Johnen, R., Zwierzyna, M., Hingorani, A. D., Beyer, A., & Partridge, L. (2022) · Aging Cell · doi:10.1111/acel.13524 · Cited by 90

The role of hydrogen sulfide in aging and age-related pathologies

Perridon, B. W., Leuvenink, H. G. D., Hillebrands, J., van Goor, H., & Bos, E. M. (2016) · Aging · doi:10.18632/aging.101026 · Cited by 90

In vivo analysis of p53 tumor suppressor function using genetically engineered mouse models

Brož, D. K., & Attardi, L. D. (2010) · Carcinogenesis · doi:10.1093/carcin/bgp331 · Cited by 92

Physical Exercise as an Epigenetic Modulator

Sanchis‐Gomar, F., García‐Giménez, J. L., Pérez-Quilis, C., Gómez‐Cabrera, M. C., Pallardó, F. V., & Lippi, G. (2012) · The Journal of Strength and Conditioning Research · doi:10.1519/jsc.0b013e31825bb594 · Cited by 88

The Regulation of Aging and Longevity: A New and Complex Role of p53

Feng, Z., Lin, M., & Wu, R. (2011) · Genes & Cancer · doi:10.1177/1947601911410223 · Cited by 88

Connecting autophagy to senescence in pathophysiology

Young, A. R. J., & Narita, M. (2010) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2009.12.005 · Cited by 98

Why do centenarians escape or postpone cancer? The role of IGF-1, inflammation and p53

Salvioli, S., Capri, M., Bucci, L., Lanni, C., Racchi, M., Uberti, D. L., Memo, M., Mari, D., Govoni, S. M., & Franceschi, C. (2009) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-008-0639-6 · Cited by 87

Combinatory approaches prevent preterm birth profoundly exacerbated by gene-environment interactions

Cha, J., Bartos, A., Egashira, M., Haraguchi, H., Saito‐Fujita, T., Leishman, E., Bradshaw, H. B., Dey, S. K., & Hirota, Y. (2013) · Journal of Clinical Investigation · doi:10.1172/jci70098 · Cited by 84

A metabolic signature predicts biological age in mice

Tomás‐Loba, A., de Jesus, B. B., Mato, J. M., & Blasco, M. A. (2012) · Aging Cell · doi:10.1111/acel.12025 · Cited by 83

Loss of p53-mediated cell-cycle arrest, senescence and apoptosis promotes genomic instability and premature aging

Li, T., Liu, X., Jiang, L., Manfredi, J. J., Zha, S., & Gu, W. (2016) · Oncotarget · doi:10.18632/oncotarget.7864 · Cited by 84

Dysfunction of the MDM2/p53 axis is linked to premature aging

Lessel, D., Wu, D., Trujillo, C., Ramezani, T., Lessel, I., Alwasiyah, M. K., Saha, B., Hisama, F. M., Rading, K., Goebel, I., et al. (2017) · Journal of Clinical Investigation · doi:10.1172/jci92171 · Cited by 84

Nutrition for Healthy Skin

Krutmann, J., & Humbert, P. G. (2010) · Springer eBooks · doi:10.1007/978-3-642-12264-4 · Cited by 82

A New Frailty Score for Experimental Animals Based on the Clinical Phenotype: Inactivity as a Model of Frailty

Gómez‐Cabrera, M. C., Garcia-Valles, R., Rodríguez‐Mañas, L., García‐García, F. J., González, G. O., Salvador‐Pascual, A., Tarazona‐Santabalbina, F. J., & Viña, J. (2017) · The Journals of Gerontology Series A · doi:10.1093/gerona/glw337 · Cited by 81

Antagonistic pleiotropy and p53

Ungewitter, E. K., & Scrable, H. J. (2008) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2008.06.002 · Cited by 88

Hormesis does not make sense except in the light of TOR-driven aging

Blagosklonny, M. V. (2011) · Aging · doi:10.18632/aging.100411 · Cited by 83

The p53 family orchestrates the regulation of metabolism: physiological regulation and implications for cancer therapy

Napoli, M., & Flores, E. R. (2016) · British Journal of Cancer · doi:10.1038/bjc.2016.384 · Cited by 80

Endothelial sprouting, proliferation, or senescence: tipping the balance from physiology to pathology

Mühleder, S., Fernández-Chacón, M., García-Gónzalez, I., & Benedito, R. (2020) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03664-y · Cited by 84

DNA Lesions Induced by Replication Stress Trigger Mitotic Aberration and Tetraploidy Development

Ichijima, Y., Yoshioka, K., Yoshioka, Y., Shinohe, K., Fujimori, H., Unno, J., Takagi, M., Goto, H., Inagaki, M., Mizutani, S., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0008821 · Cited by 83

Therapeutic targeting of p53 by small molecules

Selivanova, G. (2010) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2010.02.006 · Cited by 84

Molecular cloning, characterization and expression analysis of tumor suppressor protein p53 from orange-spotted grouper, Epinephelus coioides in response to temperature stress

Qi, Z., Liu, Y., Luo, S., Chen, C.-X., Liu, Y., & Wang, W.-N. (2013) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2013.08.011 · Cited by 78

Biology of frailty: Modulation of ageing genes and its importance to prevent age-associated loss of function

Viña, J., Tarazona‐Santabalbina, F. J., Pérez‐Ros, P., Martínez‐Arnau, F. M., Borrás, C., González, G. O., Salvador‐Pascual, A., & Gómez‐Cabrera, M. C. (2016) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2016.04.005 · Cited by 79

DNA double-strand breaks: A potential causative factor for mammalian aging?

Li, H., Mitchell, J. R., & Hasty, P. (2008) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2008.02.002 · Cited by 76

Significant correlation of species longevity with DNA double strand break recognition but not with telomere length

Lorenzini, A., Johnson, F. B., Oliver, A., Tresini, M., Smith, J. S., Hdeib, M., Sell, C., Cristofalo, V. J., & Stamato, T. D. (2009) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2009.10.004 · Cited by 73

Mitochondria as sources and targets of damage in cellular aging

Gómez‐Cabrera, M. C., Sanchis‐Gomar, F., Garcia-Valles, R., Pareja-Galeano, H., Gambini, J., Borrás, C., & Viña, J. (2012) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2011-0795 · Cited by 79

REGγ deficiency promotes premature aging via the casein kinase 1 pathway

Li, L., Zhao, D., Wei, H., Yao, L., Dang, Y., Amjad, A., Xu, J., Liu, J., Guo, L., Li, D., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1308497110 · Cited by 72

Replicative stress, stem cells and aging

Ruzankina, Y., Asare, A., & Brown, E. J. (2008) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2008.03.009 · Cited by 73

SirT3 and p53 Deacetylation in Aging and Cancer

Chen, J., Wang, A., & Chen, Q. (2017) · Journal of Cellular Physiology · doi:10.1002/jcp.25669 · Cited by 73

Cdk2: a key regulator of the senescence control function of Myc

Hydbring, P., & Larsson, L. (2010) · Aging · doi:10.18632/aging.100140 · Cited by 71

Models of reactive oxygen species in cancer

Lu, W., Ogasawara, M. A., & Huang, P. (2007) · Drug Discovery Today Disease Models · doi:10.1016/j.ddmod.2007.10.005 · Cited by 72

Telomerase gene therapy ameliorates the effects of neurodegeneration associated to short telomeres in mice

Whittemore, K., Derevyanko, A., Martinez, P., Serrano, R., Pumarola, M., Bosch, F., & Blasco, M. A. (2019) · Aging · doi:10.18632/aging.101982 · Cited by 69

Early, But Not Late Onset Estrogen Replacement Therapy Prevents Oxidative Stress and Metabolic Alterations Caused by Ovariectomy

López-Grueso, R., Gambini, J., Abdelaziz, K. M., Monleón, D., Díaz, A., Alami, M. E., Bonet-Costa, V., Borrás, C., & Viña, J. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2012.5112 · Cited by 69

Induction of DNA double-strand breaks and cellular senescence by human respiratory syncytial virus

Martínez, I., García-Carpizo, V., Guijarro, T., García-Gomez, A., Navarro, D., Aranda, A., & Zambrano, A. (2016) · Virulence · doi:10.1080/21505594.2016.1144001 · Cited by 68

Sestrin2: Its Potential Role and Regulatory Mechanism in Host Immune Response in Diseases

Wang, L., Zhu, X.-M., & Yao, Y.-M. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02797 · Cited by 68

Timed Somatic Deletion of p53 in Mice Reveals Age-Associated Differences in Tumor Progression

Hinkal, G. W., Parikh, N., & Donehower, L. A. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006654 · Cited by 68

Human exceptional longevity: transcriptome from centenarians is distinct from septuagenarians and reveals a role of Bcl-xL in successful aging

Borrás, C., Abdelaziz, K. M., Gambini, J., Serna, E., Inglés, M., la Fuente, M. D., García, I., Matheu, A., Sanchís, P., Belenguer‐Varea, Á., et al. (2016) · Aging · doi:10.18632/aging.101078 · Cited by 67

Downregulation of APE1/Ref-1 Is Involved in the Senescence of Mesenchymal Stem Cells

Heo, J. Y., Jing, K., Song, K., Seo, K.-S., Park, J., Kim, J.-S., Jung, Y.-J., Hur, G.-M., Jo, D.-Y., Kweon, G.-R., et al. (2009) · Stem Cells · doi:10.1002/stem.54 · Cited by 67

Genetic Pathways of Aging and Their Relevance in the Dog as a Natural Model of Human Aging

Sándor, S., & Kubinyi, E. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.00948 · Cited by 68

Genetics vs. entropy: Longevity factors suppress the NF-κB-driven entropic aging process

Salminen, A., & Kaarniranta, K. (2009) · Ageing Research Reviews · doi:10.1016/j.arr.2009.11.001 · Cited by 67

Regulation of p53 function by lysine methylation

West, L. E., & Gozani, O. (2011) · Epigenomics · doi:10.2217/epi.11.21 · Cited by 65

Sestrins at the crossroad between stress and aging

Lee, J. H., Bodmer, R., Bier, E., & Karin, M. (2010) · Aging · doi:10.18632/aging.100157 · Cited by 65

RasGrf1 deficiency delays aging in mice

Borrás, C., Monleón, D., López-Grueso, R., Gambini, J., Orlando, L., Pallardó, F. V., Santos, E., Viña, J., & de Mora, J. F. (2011) · Aging · doi:10.18632/aging.100279 · Cited by 64

Differentiation-induced skin cancer suppression by FOS, p53, and TACE/ADAM17

Guinea‐Viniegra, J., Zenz, R., Scheuch, H., Jiménez, M., Bakiri, L., Petzelbauer, P., & Wagner, E. F. (2012) · Journal of Clinical Investigation · doi:10.1172/jci63103 · Cited by 64

Radioprotection.

Greenberger, J. S. (2009) · PubMed · Cited by 62

Misexpression screen delineates novel genes controlling Drosophila lifespan

Paik, D., Jang, Y., Lee, Y. E., Lee, Y. N., Yamamoto, R., Gee, H. Y., Yoo, S., Bae, E., Min, K., Tatar, M., et al. (2012) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2012.02.001 · Cited by 62

Cellular Mechanisms of Somatic Stem Cell Aging

Jung, Y., & Brack, A. S. (2014) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/b978-0-12-416022-4.00014-7 · Cited by 63

Agephagy – Adapting Autophagy for Health During Aging

Stead, E. R., Castillo-Quan, J. I., Martinez-Miguel, V. E., Lujan, C., Ketteler, R., Kinghorn, K. J., & Bjedov, I. (2019) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2019.00308 · Cited by 61

The dual role of p53: DNA protection and antioxidant

Borrás, C., Gómez‐Cabrera, M. C., & Viña, J. (2011) · Free Radical Research · doi:10.3109/10715762.2011.571685 · Cited by 58

Women Live Longer than Men: Understanding Molecular Mechanisms Offers Opportunities to Intervene by Using Estrogenic Compounds

Viña, J., & Borrás, C. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.2952 · Cited by 58

The yin and yang of the Cdkn2a locus in senescence and aging

Baker, D. J., Jin, F., & van Deursen, J. M. (2008) · Cell Cycle · doi:10.4161/cc.7.18.6687 · Cited by 56

Balancing DNA repair to prevent ageing and cancer

Stead, E. R., & Bjedov, I. (2021) · Experimental Cell Research · doi:10.1016/j.yexcr.2021.112679 · Cited by 62

p53 as an intervention target for cancer and aging

Hasty, P., & Christy, B. A. (2013) · Pathobiology of Aging & Age-related Diseases · doi:10.3402/pba.v3i0.22702 · Cited by 57

Radiation and SN38 treatments modulate the expression of microRNAs, cytokines and chemokines in colon cancer cells in a p53-directed manner

Pathak, S., Meng, W., Nandy, S. K., Ping, J., Bişgin, A., Helmfors, L., Waldmann, P., & Sun, X.-F. (2015) · Oncotarget · doi:10.18632/oncotarget.5815 · Cited by 56

Emerging roles of nucleolar and ribosomal proteins in cancer, development, and aging

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