New plays in the p53 theater
Open accessAbstract
The p53 tumor suppressor and its paralogs p63 and p73 are at the crux of a network modulating cellular responses against potentially tumorigenic events. p53 acts primarily as a transcription factor, regulating the expression of both coding and non-coding RNAs, as well as the activity of RNA processing complexes. In line with their anti-tumorigenic function, p53 and p63 have recently been implicated in restricting tumor cell invasion. In parallel, a growing number of non-canonical target genes have been added to the p53 repertoire. These include genes encoding for proteins that impinge on a broad spectrum of cellular functions, from cell metabolism to stem cell renewal. The p53 story is still far from being fully told.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
A missense mutation in the p53 transcription factor can be held accountable for tumor initiation, development, and growth in more than half of solid tumor cancers.
“For instance, a missense mutation in the p53 transcription factor, which can be held accountable for tumor initiation, development, and growth in more than half of solid tumor cancers [32].”
From Microfluidic modelling of the tumor microenvironment for anti-cancer drug development (2019) · cites this paper as [32]
The Introduction (page unavailable) says p53 is mutated in approximately 50% of human cancers and describes its role in tumor prevention. The section on tumor cell invasion (page unavailable) says mutant p53 can promote cancer progression and metastasis. Neither passage establishes that the mutations are specifically missense mutations, that the figure exceeds half, or that it applies specifically to solid tumors. (LLM, conf=0.88)
Experimental — accuracy not yet measuredThe p53 protein acts as a tumor suppressor by inducing apoptosis when cellular mutations occur and initiating DNA repairs in healthy cells.
“Briefly, the p53 protein acts as a tumor suppressor as it induces apoptosis when cellular mutations occur and initiate DNA repairs in healthy cells [32].”
From Microfluidic modelling of the tumor microenvironment for anti-cancer drug development (2019) · cites this paper as [32]
The Introduction says that stress activates p53, which facilitates DNA repair and can instigate apoptosis; it also describes p53’s role in tumor prevention. It does not specifically say that mutations trigger apoptosis or distinguish DNA repair in healthy cells from repair in other cells. (LLM, conf=0.82)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours
Donehower, L. A., Harvey, M., Slagle, B. L., McArthur, M. J., Montgomery, C. A., Butel, J. S., & Bradley, A. (1992) · Nature · doi:10.1038/356215a0 · Cited by 4,649 · see citing works
Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals
Guttman, M., Amit, I., Garber, M., French, C., Lin, M. F., Feldser, D., Huarte, M., Zuk, O., Carey, B. W., Cassady, J. P., et al. (2009) · Nature · doi:10.1038/nature07672 · Cited by 4,098 · see citing works
Blinded by the Light: The Growing Complexity of p53
Vousden, K. H., & Prives, C. (2009) · Cell · doi:10.1016/j.cell.2009.04.037 · Cited by 3,163 · see citing works
Khalil, A. M., Guttman, M., Huarte, M., Garber, M., Raj, A., Rivea Morales, D., Thomas, K., Presser, A., Bernstein, B. E., van Oudenaarden, A., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0904715106 · Cited by 2,872 · see citing works
A microRNA component of the p53 tumour suppressor network
He, L., He, X., Lim, L. P., de Stanchina, E., Xuan, Z., Liang, Y., Xue, W., Zender, L., Magnus, J., Ridzon, D., et al. (2007) · Nature · doi:10.1038/nature05939 · Cited by 2,692 · see citing works
TIGAR, a p53-Inducible Regulator of Glycolysis and Apoptosis
Bensaad, K., Tsuruta, A., Selak, M. A., Vidal, M. N. C., Nakano, K., Bartrons, R., Gottlieb, E., & Vousden, K. H. (2006) · Cell · doi:10.1016/j.cell.2006.05.036 · Cited by 2,019 · see citing works
The first 30 years of p53: growing ever more complex.
Levine, A. J., & Oren, M. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2723 · Cited by 1,967 · see citing works
Self-citationAMP-activated protein kinase induces a p53-dependent metabolic checkpoint
Jones, R. G., Plas, D. R., Kubek, S., Buzzai, M., Mu, J., Xu, Y., Birnbaum, M. J., & Thompson, C. B. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.03.027 · Cited by 1,619 · see citing works
DRAM, a p53-Induced Modulator of Autophagy, Is Critical for Apoptosis
Crighton, D., Wilkinson, S., O'Prey, J., Syed, N., Smith, P., Harrison, P. R., Gasco, M., Garrone, O., Crook, T., & Ryan, K. M. (2006) · Cell · doi:10.1016/j.cell.2006.05.034 · Cited by 1,380 · see citing works
Transcriptional Activation of miR-34a Contributes to p53-Mediated Apoptosis
Raver-Shapira, N., Marciano, E., Meiri, E., Spector, Y., Rosenfeld, N., Moskovits, N. B.-C., Bentwich, Z., & Oren, M. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.05.017 · Cited by 1,352 · see citing works
Self-citationmiR-34a repression of SIRT1 regulates apoptosis
Yamakuchi, M., Ferlito, M., & Lowenstein, C. J. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0801613105 · Cited by 1,344 · see citing works
Suppression of induced pluripotent stem cell generation by the p53–p21 pathway
Hong, H., Takahashi, K., Ichisaka, T., Aoi, T., Kanagawa, O., Nakagawa, M., Okita, K., & Yamanaka, S. (2009) · Nature · doi:10.1038/nature08235 · Cited by 1,301 · see citing works
The coordinate regulation of the p53 and mTOR pathways in cells
Feng, Z., Zhang, H., Levine, A. J., & Jin, S. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0502857102 · Cited by 1,235 · see citing works
Regulation of autophagy by cytoplasmic p53
Tasdemir, E., Maiuri, M. C., Galluzzi, L., Vitale, I., Djavaheri-Mergny, M., D'Amelio, M., Criollo, A., Morselli, E., Zhu, C., Harper, F., et al. (2008) · Nature Cell Biology · doi:10.1038/ncb1730 · Cited by 1,132 · see citing works
Modulation of microRNA processing by p53
Suzuki, H. I., Yamagata, K., Sugimoto, K., Iwamoto, T., Kato, S., & Miyazono, K. (2009) · Nature · doi:10.1038/nature08199 · Cited by 1,125 · see citing works
Linking the p53 tumour suppressor pathway to somatic cell reprogramming
Kawamura, T., Suzuki, J., Wang, Y. V., Menendez, S., Morera, L. B., Raya, A., Wahl, G. M., & Belmonte, J. C. I. (2009) · Nature · doi:10.1038/nature08311 · Cited by 1,115 · see citing works
The antioxidant function of the p53 tumor suppressor
Sablina, A. A., Budanov, A. V., Ilyinskaya, G. V., Agapova, L. S., Kravchenko, J. E., & Chumakov, P. M. (2005) · Nature Medicine · doi:10.1038/nm1320 · Cited by 1,110 · see citing works
Brick by brick: metabolism and tumor cell growth
DeBerardinis, R. J., Sayed, N., Ditsworth, D., & Thompson, C. B. (2008) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2008.02.003 · Cited by 1,018 · see citing works
Chin, L., Artandi, S. E., Shen, Q., Tam, A., Lee, S.-L., Gottlieb, G. J., Greider, C. W., & DePinho, R. A. (1999) · Cell · doi:10.1016/s0092-8674(00)80762-x · Cited by 979 · cited 1× · see citing works
“Germline deletion of p53 in mice with critically short telomeres spares damaged SCs from apoptosis and protracts their survival [53,54].”
BackgroundThe Ink4/Arf locus is a barrier for iPS cell reprogramming
Li, H., Collado, M., Villasante, A., Strati, K., Ortega, S., Cañamero, M., Blasco, M. A., & Serrano, M. (2009) · Nature · doi:10.1038/nature08290 · Cited by 968 · see citing works
Immortalization eliminates a roadblock during cellular reprogramming into iPS cells
Utikal, J., Polo, J., Stadtfeld, M., Maherali, N., Kulalert, W., Walsh, R. M., Khalil, A., Rheinwald, J., & Hochedlinger, K. (2009) · Nature · doi:10.1038/nature08285 · Cited by 896 · see citing works
p53 induces differentiation of mouse embryonic stem cells by suppressing Nanog expression
Lin, T., Chao, C., Saito, S., Mazur, S. J., Murphy, M. E., Appella, E., & Xu, Y. (2004) · Nature Cell Biology · doi:10.1038/ncb1211 · Cited by 859 · see citing works
p53 represses c-Myc through induction of the tumor suppressor miR-145
Sachdeva, M., Zhu, S., Wu, F., Wu, H., Walia, V., Kumar, S. R., Elble, R. C., Watabe, K., & Mo, Y. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808042106 · Cited by 841 · see citing works
Mutant p53 drives invasion by promoting integrin recycling
Muller, P. A. J., Caswell, P. T., Doyle, B., Iwanicki, M. P., Tan, E. H., Karim, S., Lukashchuk, N., Gillespie, D. A., Ludwig, R. L., Gosselin, P., et al. (2009) · Cell · doi:10.1016/j.cell.2009.11.026 · Cited by 796 · see citing works
A Mutant-p53/Smad Complex Opposes p63 to Empower TGFβ-Induced Metastasis
Adorno, M., Cordenonsi, M., Montagner, M., Dupont, S., Wong, C., Hann, B. C., Solari, A., Bobisse, S., Rondina, M. B., Guzzardo, V., et al. (2009) · Cell · doi:10.1016/j.cell.2009.01.039 · Cited by 783 · see citing works
Mutant p53 Gain-of-Function in CancerPreprint
Oren, M., & Rotter, V. (2009) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a001107 · Cited by 753 · see citing works
Self-citationThe Tumor Suppressor p53 Regulates Polarity of Self-Renewing Divisions in Mammary Stem Cells
Cicalese, A., Bonizzi, G., Pasi, C. E., Faretta, M., Ronzoni, S., Giulini, B., Brisken, C., Minucci, S., Fiore, P. P. D., & Pelicci, P. G. (2009) · Cell · doi:10.1016/j.cell.2009.06.048 · Cited by 695 · see citing works
Senescence impairs successful reprogramming to pluripotent stem cells
Banito, A., Rashid, S. T., Acosta, J. C., Li, S., Pereira, C. F., Geti, I., Pinho, S., Silva, J. C., Azuara, V., Walsh, M., et al. (2009) · Genes & Development · doi:10.1101/gad.1811609 · Cited by 642 · see citing works
p53 regulates glucose metabolism through an IKK-NF-κB pathway and inhibits cell transformation
Kawauchi, K., Araki, K., Tobiume, K., & Tanaka, N. (2008) · Nature Cell Biology · doi:10.1038/ncb1724 · Cited by 635 · see citing works
Feng, Z., Hu, W., de Stanchina, E., Teresky, A. K., Jin, S., Lowe, S., & Levine, A. J. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-4149 · Cited by 633 · see citing works
p53 Regulates Hematopoietic Stem Cell Quiescence
Liu, Y., Elf, S. E., Miyata, Y., Sashida, G., Liu, Y., Huang, G., Di Giandomenico, S., Lee, J. M., Deblasio, A., Menendez, S., et al. (2009) · Cell Stem Cell · doi:10.1016/j.stem.2008.11.006 · Cited by 547 · see citing works
p53 controls cancer cell invasion by inducing the MDM2-mediated degradation of Slug
Wang, S.-P., Wang, W.-L., Chang, Y.-L., Wu, C.-T., Chao, Y.-C., Kao, S.-H., Yuan, A., Lin, C.-W., Yang, S.-C., Chan, W.-K., et al. (2009) · Nature Cell Biology · doi:10.1038/ncb1875 · Cited by 493 · see citing works
p53-Responsive MicroRNAs 192 and 215 Are Capable of Inducing Cell Cycle Arrest
Braun, C. J., Zhang, X., Savelyeva, I., Wolff, S., Moll, U. M., Schepeler, T., Orntoft, T. F., Andersen, C. L., & Dobbelstein, M. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-1569 · Cited by 467 · see citing works
Delayed ageing through damage protection by the Arf/p53 pathway
Matheu, A., Maraver, A., Klatt, P., Flores, I., Garcia-Cao, I., Borras, C., Flores, J. M., Viña, J., Blasco, M. A., & Serrano, M. (2007) · Nature · doi:10.1038/nature05949 · Cited by 466 · see citing works
Li, N., Fu, H., Tie, Y., Hu, Z., Kong, W., Wu, Y., & Zheng, X. (2008) · Cancer Letters · doi:10.1016/j.canlet.2008.09.035 · Cited by 418 · see citing works
p63 regulates an adhesion programme and cell survival in epithelial cells
Carroll, D. K., Carroll, J. S., Leong, C., Cheng, F., Brown, M. A., Mills, A. A., Brugge, J. S., & Ellisen, L. W. (2006) · Nature Cell Biology · doi:10.1038/ncb1420 · Cited by 403 · see citing works
The regulation of energy metabolism and the IGF-1/mTOR pathways by the p53 protein
Feng, Z., & Levine, A. J. (2010) · Trends in Cell Biology · doi:10.1016/j.tcb.2010.03.004 · Cited by 359 · see citing works
p53-independent upregulation of miR-34a during oncogene-induced senescence represses MYC
Christoffersen, N. R., Shalgi, R., Frankel, L. B., Leucci, E., Lees, M., Klausen, M., Pilpel, Y., Nielsen, F. C., Oren, M., & Lund, A. H. (2010) · Cell Death & Differentiation · doi:10.1038/cdd.2009.109 · Cited by 352 · see citing works
Self-citationp53-Mediated Hematopoietic Stem and Progenitor Cell Competition
Bondar, T., & Medzhitov, R. (2010) · Cell Stem Cell · doi:10.1016/j.stem.2010.03.002 · Cited by 342 · see citing works
Milyavsky, M., Gan, O. I., Trottier, M., Komosa, M., Tabach, O., Notta, F., Lechman, E. R., Hermans, K. G., Eppert, K., Konovalova, Z., et al. (2010) · Cell stem cell · doi:10.1016/j.stem.2010.05.016 · Cited by 280 · see citing works
Feng, Z., Hu, W., Teresky, A. K., Hernando, E., Cordon-Cardo, C., & Levine, A. J. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0708043104 · Cited by 264 · see citing works
Regulation of Apoptosis and Differentiation by p53 in Human Embryonic Stem Cells
Qin, H., Yu, T., Qing, T., Liu, Y., Zhao, Y., Cai, J., Li, J., Song, Z., Qu, X., Zhou, P., et al. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m610464200 · Cited by 244 · see citing works
Loss of p53 promotes RhoA–ROCK-dependent cell migration and invasion in 3D matrices
Gadéa, G., de Toledo, M., Anguille, C., & Roux, P. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200701120 · Cited by 244 · see citing works
Pang, R. T. K., Leung, C. O. N., Ye, T.-M., Liu, W., Chiu, P. C. N., Lam, K. K. W., Lee, C., & Yeung, W. S. B. (2010) · Carcinogenesis · doi:10.1093/carcin/bgq066 · Cited by 242 · see citing works
Barbieri, C. E., Tang, L. J., Brown, K., & Pietenpol, J. A. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-2020 · Cited by 232 · see citing works
Suppression of induced pluripotent stem cell generation by the p53-p21 pathway
洪, 炫. (2012) · Medical Entomology and Zoology · Cited by 198 · see citing works
p53 loss promotes acute myeloid leukemia by enabling aberrant self-renewalPreprint
Zhao, Z., Zuber, J. A., Díaz-Flores, E., Lintault, L., Kogan, S. C., Shannon, K., & Lowe, S. W. (2010) · Genes & Development · doi:10.1101/gad.1940710 · Cited by 167 · see citing works
p53 is balancing development, differentiation and de-differentiation to assure cancer prevention
Molchadsky, A., Rivlin, N., Brosh, R., Rotter, V., & Sarig, R. (2010) · Carcinogenesis · doi:10.1093/carcin/bgq101 · Cited by 156 · see citing works
Sarig, R., Rivlin, N., Brosh, R., Bornstein, C., Kamer, I., Ezra, O., Molchadsky, A., Goldfinger, N., Brenner, O. J., & Rotter, V. (2010) · The Journal of Experimental Medicine · doi:10.1084/jem.20100797 · Cited by 155 · see citing works
p53‐repressed miRNAs are involved with E2F in a feed‐forward loop promoting proliferation
Brosh, R., Shalgi, R., Liran, A., Landan, G., Korotayev, K., Nguyen, G. H., Enerly, E., Johnsen, H., Buganim, Y., Solomon, H., et al. (2008) · Molecular Systems Biology · doi:10.1038/msb.2008.65 · Cited by 152 · see citing works
Self-citationp53 and the Li-Fraumeni syndrome
Malkin, D. M. (1993) · Cancer Genetics and Cytogenetics · doi:10.1016/0165-4608(93)90233-c · Cited by 151 · see citing works
A pivotal role for p53: balancing aerobic respiration and glycolysis
Ma, W., Sung, H. J., Park, J., Matoba, S., & Hwang, P. M. (2007) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-007-9083-0 · Cited by 150 · see citing works
Induced pluripotent stem cells and senescence: learning the biology to improve the technology
Banito, A., & Gil, J. (2010) · EMBO Reports · doi:10.1038/embor.2010.47 · Cited by 117 · see citing works
Tumourigenesis associated with the p53 tumour suppressor gene
Chang, F., Syrjänen, S., Tervahauta, A. I., & Syrjänen, K. J. (1993) · British Journal of Cancer · doi:10.1038/bjc.1993.404 · Cited by 116 · see citing works
Begus‐Nahrmann, Y., Lechel, A., Obenauf, A. C., Nalapareddy, K., Peit, E., Hoffmann, E. M., Schlaudraff, F., Liss, B., Schirmacher, P., Kestler, H. A., et al. (2009) · Nature Genetics · doi:10.1038/ng.426 · Cited by 104 · see citing works
p53 inhibits tumor cell invasion via the degradation of snail protein in hepatocellular carcinoma
Lim, S., Kim, H., & Jung, G. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.04.006 · Cited by 102 · see citing works
Sankpal, N. V., Willman, M. W., Fleming, T. P., Mayfield, J. D., & Gillanders, W. E. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-2708 · Cited by 91 · see citing works
Flores, I., & Blasco, M. A. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004934 · Cited by 83 · see citing works
Dong, P., Xu, Z., Jia, N., Li, D., & Feng, Y. (2009) · Molecular Cancer · doi:10.1186/1476-4598-8-103 · Cited by 75 · see citing works
p63 contributes to cell invasion and migration in squamous cell carcinoma of the head and neck
Gu, X., Coates, P. J., Boldrup, L., & Nylander, K. (2008) · Cancer Letters · doi:10.1016/j.canlet.2007.12.011 · Cited by 49 · see citing works
Regulation of VDR by ΔNp63α is associated with inhibition of cell invasion
Kommagani, R., Leonard, M. K., Lewis, S., Romano, R., Sinha, S., & Kadakia, M. (2009) · Journal of Cell Science · doi:10.1242/jcs.049619 · Cited by 47 · see citing works
Moran, D. M., & Maki, C. G. (2010) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-09-1220 · Cited by 35 · see citing works
p53 Regulation Orchestrates the TGF-β Response
Piccolo, S. (2008) · Cell · doi:10.1016/j.cell.2008.05.013 · Cited by 27 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Ferroptosis as a p53-mediated activity during tumour suppression
Jiang, L., Kon, N., Li, T., Wang, S.-J., Su, T., Hibshoosh, H., Baer, R., & Gu, W. (2015) · Nature · doi:10.1038/nature14344 · Cited by 3,398 · see citing works
Rivlin, N., Brosh, R., Oren, M., & Rotter, V. (2011) · Genes & Cancer · doi:10.1177/1947601911408889 · Cited by 1,033 · see citing works
Self-citationInterleukin-1 Beta—A Friend or Foe in Malignancies?
Bent, R., Moll, L., Grabbe, S., & Bros, M. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19082155 · Cited by 451 · see citing works
Tumour-associated mutant p53 drives the Warburg effect
Zhang, C., Liu, J., Liang, Y., Wu, R., Zhao, Y., Hong, X., Lin, M., Yu, H., Liu, L., Levine, A. J., et al. (2013) · Nature Communications · doi:10.1038/ncomms3935 · Cited by 434 · see citing works
TP53 Mutations in Human Cancer: Database Reassessment and Prospects for the Next Decade
Leroy, B., Anderson, M., & Soussi, T. (2014) · Human Mutation · doi:10.1002/humu.22552 · Cited by 412 · see citing works
TERT—Regulation and Roles in Cancer Formation
Dratwa, M., Wysoczańska, B., Łacina, P., Kubik, T., & Bogunia‐Kubik, K. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.589929 · Cited by 314 · see citing works
Liao, M., Yao, D., Wu, L., Luo, C., Wang, Z., Zhang, J., & Liu, B. (2023) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2023.12.003 · Cited by 280 · see citing works
ZEB/miR‐200 feedback loop: At the crossroads of signal transduction in cancer
Hill, L., Browne, G. J., & Tulchinsky, E. M. (2012) · International Journal of Cancer · doi:10.1002/ijc.27708 · Cited by 261 · see citing works
Microfluidic modelling of the tumor microenvironment for anti-cancer drug development
Shang, M., Soon, R. H., Lim, C. T., Khoo, B. L., & Han, J. (2019) · Lab on a Chip · doi:10.1039/c8lc00970h · Cited by 227 · see citing works
Gain-of-Function Mutant p53: All the Roads Lead to Tumorigenesis
Stein, Y., Rotter, V., & Aloni-Grinstein, R. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20246197 · Cited by 161 · see citing works
Cui, Y. R., & Guo, G. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17111942 · Cited by 135 · see citing works
Werner, H. (2011) · Oncogene · doi:10.1038/onc.2011.447 · Cited by 127 · see citing works
de la Vega, L., Grishina, I., Moreno, R., Krüger, M., Braun, T. W., & Schmitz, M. L. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.03.003 · Cited by 106 · see citing works
Alterations of theTP53Gene in Gastric and Esophageal Carcinogenesis
Bellini, M. F., Cadamuro, A. C. T., Succi, M., Proença, M. A., & Silva, A. E. (2012) · BioMed Research International · doi:10.1155/2012/891961 · Cited by 104 · see citing works
Schauer, I. G., Zhang, J., Xing, Z., Guo, X. Q., Mercado‐Uribe, I., Sood, A. K., Huang, P., & Liu, J. (2013) · Neoplasia · doi:10.1593/neo.121228 · Cited by 97 · see citing works
Tumor suppressor p53 negatively regulates glycolysis stimulated by hypoxia through its target RRAD
Zhang, C., Liu, J., Wu, R., Liang, Y., 林美华, Liu, J., Chan, C. S., Hu, W., & Feng, Z. (2014) · Oncotarget · doi:10.18632/oncotarget.2137 · Cited by 97 · see citing works
Low-dose radiation exposure induces a HIF-1-mediated adaptive and protective metabolic response
Lall, R., Ganapathy, S., Yang, M., Xiao, S., Teng, X., Su, H., Shadfan, M., Asara, J. M., Ha, C. S., Ben‐Sahra, I., et al. (2014) · Cell Death and Differentiation · doi:10.1038/cdd.2014.24 · Cited by 92 · see citing works
Porter, J. R., Fisher, B. E., & Batchelor, E. (2016) · Cell Systems · doi:10.1016/j.cels.2016.03.006 · Cited by 92 · see citing works
Zampetidis, C., Galanos, P., Angelopoulou, A., Zhu, Y., Polyzou, A., Karamitros, T., Kotsinas, A., Lаgopati, N., Mourkioti, I., Mirzazadeh, R., et al. (2021) · Molecular Cell · doi:10.1016/j.molcel.2021.10.017 · Cited by 90 · see citing works
Alternative splicings on p53, BRCA1 and PTEN genes involved in breast cancer
Okumura, N., Yoshida, H., Kitagishi, Y., Nishimura, Y., & Matsuda, S. (2011) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2011.08.098 · Cited by 80 · see citing works
The p53 control of apoptosis and proliferation: lessons from Drosophila
Mollereau, B., & Ma, D. (2014) · APOPTOSIS · doi:10.1007/s10495-014-1035-7 · Cited by 71 · see citing works
ArhGAP30 promotes p53 acetylation and function in colorectal cancer
Wang, J., Qian, J., Hu, Y., Kong, X., Chen, H., Shi, Q., Jiang, L., Wu, C., Zou, W., Chen, Y., et al. (2014) · Nature Communications · doi:10.1038/ncomms5735 · Cited by 69 · see citing works
Marchese, E., Vignati, A., Albanese, A., Nucci, C. G., Sabatino, G., Tirpakova, B., Lofrese, G., Zelano, G., & Maira, G. (2010) · PubMed · Cited by 67 · see citing works
Melanocytes: A Window into the Nervous System
Yaar, M., & Park, H. (2011) · Journal of Investigative Dermatology · doi:10.1038/jid.2011.386 · Cited by 66 · see citing works
STEAP3 Affects Ferroptosis and Progression of Renal Cell Carcinoma Through the p53/xCT Pathway
Ye, C. L., Du, Y., Yu, X., Chen, Z. Y., Wang, L., Zheng, Y. F., & Liu, X. H. (2022) · Technology in Cancer Research & Treatment · doi:10.1177/15330338221078728 · Cited by 64 · see citing works
Liang, Y., Zhang, D., Zheng, T., Yang, G., Wang, J., Meng, F., Liu, Y., Zhang, G., Zhang, L., Han, J., et al. (2020) · Oncogenesis · doi:10.1038/s41389-020-0242-z · Cited by 60 · see citing works
Werner, H., & Sarfstein, R. (2014) · Growth Hormone & IGF Research · doi:10.1016/j.ghir.2014.03.006 · Cited by 57 · see citing works
Targeting Loss of Heterozygosity: A Novel Paradigm for Cancer Therapy
Zhang, X., & Sjöblom, T. (2021) · Pharmaceuticals · doi:10.3390/ph14010057 · Cited by 56 · see citing works
A comprehensive study of p53 protein
Patil, M. R., & Bihari, A. (2022) · Journal of Cellular Biochemistry · doi:10.1002/jcb.30331 · Cited by 55 · see citing works
Cyclin D mediates tolerance of genome-doubling in cancers with functional p53
Crockford, A., Zalmas, L., Gronroos, E. C., Dewhurst, S. M., McGranahan, N., Cuomo, M. E., Encheva, V., Snijders, A. P., Begum, J., Purewal, S., et al. (2016) · Annals of Oncology · doi:10.1093/annonc/mdw612 · Cited by 57 · see citing works
Regulation of skin aging and heart development by TAp63
Paris, M., Rouleau, M., Pucéat, M., & Aberdam, D. (2011) · Cell Death and Differentiation · doi:10.1038/cdd.2011.181 · Cited by 54 · see citing works
Craene, B. D., Denecker, G., Vermassen, P., Taminau, J., Mauch, C., Derore, A., Jonkers, J., Fuchs, E. V., & Berx, G. (2013) · Cell Death and Differentiation · doi:10.1038/cdd.2013.148 · Cited by 54 · see citing works
Role of the GH-IGF1 system in progression of cancer.
Werner, H., & Laron, Z. (2020) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2020.111003 · Cited by 42 · see citing works
PCDH10, a novel p53 transcriptional target in regulating cell migration
Shi, D., Murty, V. V. V. S., & Gu, W. J. (2015) · Cell Cycle · doi:10.1080/15384101.2015.1004935 · Cited by 51 · see citing works
Alternative Splicing in Breast Cancer and the Potential Development of Therapeutic Tools
Martínez-Montiel, N., Anaya-Ruı́z, M., Pérez-Santos, M., & Martínez-Contreras, R. D. (2017) · Genes · doi:10.3390/genes8100217 · Cited by 49 · see citing works
Denisenko, T. V., Pivnyuk, A. D., & Zhivotovsky, B. (2018) · Cancers · doi:10.3390/cancers10050148 · Cited by 49 · see citing works
Guo, G., & Cui, Y. R. (2015) · Journal for ImmunoTherapy of Cancer · doi:10.1186/s40425-015-0053-5 · Cited by 45 · see citing works
Modeling the Basal Dynamics of P53 System
Sun, T., Yang, W., Liu, J., & Shen, P. (2011) · PLoS ONE · doi:10.1371/journal.pone.0027882 · Cited by 42 · see citing works
TSPAN2 Is Involved in Cell Invasion and Motility during Lung Cancer Progression
Otsubo, C., Otomo, R., Miyazaki, M., Matsushima‐Hibiya, Y., Kohno, T., Iwakawa, R., Takeshita, F., Okayama, H., Ichikawa, H., Saya, H., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.03.027 · Cited by 41 · see citing works
Haque, E., Kamil, M., Hasan, A., Irfan, S., Sheikh, S., Khatoon, A., Nazir, A., & Mir, S. S. (2019) · Glycobiology · doi:10.1093/glycob/cwz073 · Cited by 41 · see citing works
The emerging functions of the p53-miRNA network in stem cell biology
Lin, C.-P., Choi, Y. J., Hicks, G. G., & He, L. (2012) · Cell Cycle · doi:10.4161/cc.20207 · Cited by 38 · see citing works
Fleury, H., Communal, L., Carmona, E., Portelance, L., Arcand, S. L., Rahimi, K., Tonin, P. N., Provencher, D. M., & Mes‐Masson, A. (2015) · Genes & Cancer · doi:10.18632/genesandcancer.76 · Cited by 36 · see citing works
Role of the promyelocytic leukaemia protein in cell death regulation
Salomoni, P., Dvorkina, M., & Michod, D. (2012) · Cell Death and Disease · doi:10.1038/cddis.2011.122 · Cited by 35 · see citing works
Zhao, Q., Fan, J., Wei, H., Li, L., & Wu, M. (2012) · SpringerPlus · doi:10.1186/2193-1801-1-65 · Cited by 33 · see citing works
Özdemir, E. S., Halakou, F., Nussinov, R., Gürsoy, A., & Keskin, Ö. (2018) · Methods in molecular biology · doi:10.1007/978-1-4939-8955-3_1 · Cited by 34 · see citing works
p53 balances between tissue hierarchy and anarchy
Koifman, G., Aloni-Grinstein, R., & Rotter, V. (2019) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjz022 · Cited by 33 · see citing works
Polato, F., Rusconi, P., Zangrossi, S., Morelli, F., Boeri, M., Musi, A., Marchini, S., Castiglioni, V., Scanziani, E., Torri, V., et al. (2014) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/dju053 · Cited by 30 · see citing works
Kim, J. Y., Han, S. Y., Yoo, J. H., Kim, G. W., Jeon, Y. H., Lee, S. W., Park, J., & Kwon, S. H. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23158645 · Cited by 28 · see citing works
p53 in cell invasion, podosomes, and invadopodia
Mak, A. S. (2014) · Cell Adhesion & Migration · doi:10.4161/cam.27841 · Cited by 27 · see citing works
Kim, J., Chang, J. W., Park, J. K., & Hwang, S. (2012) · Cancer Biology & Therapy · doi:10.4161/cbt.20081 · Cited by 27 · see citing works
Dioufa, N., Chatzistamou, I., Farmaki, E., Papavassiliou, A. G., & Kiaris, H. (2012) · Experimental Biology and Medicine · doi:10.1258/ebm.2012.012140 · Cited by 26 · see citing works
Pouladi, N., Montasser-Kouhsari, S., Feizi, M. A. H., Gavgani, R. R., & Azarfam, P. (2013) · Asian Pacific Journal of Cancer Prevention · doi:10.7314/apjcp.2013.14.6.3503 · Cited by 26 · see citing works
Recent progress in genetics of aging, senescence and longevity: focusing on cancer-related genes
Berman, A. E., Leontieva, O. V., Natarajan, V., McCubrey, J. A., Demidenko, Z. N., & Nikiforov, M. A. (2012) · Oncotarget · doi:10.18632/oncotarget.889 · Cited by 23 · see citing works
Overexpression of MCPH1 inhibits the migration and invasion of lung cancer cells
Wu, X., Liu, W., Liu, X., Ai, Q., & Yu, J. (2018) · OncoTargets and Therapy · doi:10.2147/ott.s156102 · Cited by 22 · see citing works
p53 controls CDC7 levels to reinforce G1 cell cycle arrest upon genotoxic stress
Tudzarova, S., Mulholland, P. J., Dey, A., Stoeber, K., Okorokov, A. L., & Williams, G. H. (2016) · Cell Cycle · doi:10.1080/15384101.2016.1231281 · Cited by 22 · see citing works
Yang, Y., Jiang, B., Shi, L., Wang, L., Yang, Y., Li, Y., Zhang, Y., Zhu, Z., Zhang, X., & Liu, X. (2025) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2025.119555 · Cited by 22 · see citing works
Silveira, H. S., Lupi, L. A., Romagnoli, G. G., Kaneno, R., Nunes, I. D. S., Fávaro, W. J., & Chuffa, L. G. D. A. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.117786 · Cited by 18 · see citing works
Disease association of human tumor suppressor genes
Das, A. B. (2019) · Molecular Genetics and Genomics · doi:10.1007/s00438-019-01557-9 · Cited by 16 · see citing works
Genome-wide analysis of the p53 gene regulatory network in the developing mouse kidney
Li, Y., Liu, J., McLaughlin, N., Bachvarov, D. R., Saifudeen, Z. R., & El-Dahr, S. S. (2013) · Physiological Genomics · doi:10.1152/physiolgenomics.00113.2013 · Cited by 16 · see citing works
Anitha, S., Digumarti, R., Waliyar, F., Sudini, H., Parveen, M., Rao, R., & Kumar, P. L. (2014) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2013.12.011 · Cited by 16 · see citing works
Payandeh, M., Sadeghi, M., Sadeghi, E., & Madani, S.-H. (2016) · Asian Pacific Journal of Cancer Prevention · doi:10.7314/apjcp.2015.17.3.1261 · Cited by 15 · see citing works
Vuong, L., Brobst, D. E., Saadi, A., Ivanovic, I., & Al‐Ubaidi, M. R. (2012) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.11-8681 · Cited by 13 · see citing works
Lucchesi, C. A., Zhang, J., Gao, M., Shaw, J. T., & Chen, X. (2023) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-22-0627 · Cited by 12 · see citing works
Chang, L.-J., & Eastman, A. R. (2012) · Cancer Biology & Therapy · doi:10.4161/cbt.21047 · Cited by 12 · see citing works
Tomas, F., Roux, P., & Gire, V. (2024) · Cell Death and Disease · doi:10.1038/s41419-024-07213-4 · Cited by 11 · see citing works
Ferreira, W. A. S., Burbano, R. M. R., Pessoa, C. D. Ó., Harada, M. L., Borges, B. D. N., & de Oliveira, E. H. C. (2020) · Anti-Cancer Agents in Medicinal Chemistry · doi:10.2174/1871520620666200203160117 · Cited by 10 · see citing works
Alaee, M., Padda, A., Mehrabani, V., Churchill, L., & Pasdar, M. (2016) · Oncotarget · doi:10.18632/oncotarget.8616 · Cited by 10 · see citing works
Hainaut, P. L., Wiman, K. G., & Olivier, M. (2012) · Springer eBooks · doi:10.1007/978-1-4614-3676-8 · Cited by 10 · see citing works
CDKL3 Targets ATG5 to Promote Carcinogenesis of Esophageal Squamous Cell Carcinoma
Zhou, S., Zhang, M., Chao Hui, Z. H. O. U., Wang, W., Yang, H., & Ye, W. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.01602 · Cited by 10 · see citing works
Liu, X., Wang, J., Wu, L., Trinh, B., & Tsai, R. Y. L. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25115992 · Cited by 9 · see citing works
Ci, X., Yu, Z., Tang, W., Tu, Q., Jiang, P., Xue, X., Saunders, N. A., Zhang, L., Zhu, X., & Zhao, K. (2020) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-020-10492-4 · Cited by 9 · see citing works
Alzaidi, M. A., Arab, H. A., Amanpour, S., Shirkoohi, R., Muhammadnejad, S., & Sasani, F. (2018) · Journal of Gastrointestinal Cancer · doi:10.1007/s12029-017-0050-7 · Cited by 8 · see citing works
TP53: Coordinator of the Processes That Underlie the Hallmarks of Cancer
Hainaut, P. L. (2012) · Springer eBooks · doi:10.1007/978-1-4614-3676-8_1 · Cited by 7 · see citing works
Progress and challenges in understanding the regulation and function of p53 dynamics
Yang, Z., Hanson, R. L., & Batchelor, E. (2021) · Biochemical Society Transactions · doi:10.1042/bst20210148 · Cited by 7 · see citing works
The Biological Function and Clinical Significance of miR-886-5p in Multiple Myeloma
Xiang, P., Liu, Y., Liu, L., Lin, Q., Liu, X., Zhang, H., Xu, J., & Fang, B. (2019) · Acta Haematologica · doi:10.1159/000499620 · Cited by 7 · see citing works
Xu, C., Yang, X., Wang, Y., Ding, N., Han, R., Sun, Y., & Wang, Y. (2017) · Cancer Gene Therapy · doi:10.1038/cgt.2017.17 · Cited by 6 · see citing works
Association of EGF and p53 gene polymorphisms and colorectal cancer risk in the Slovak population
Mahmood, S., Sivoňová, M. K., Matáková, T., Dobrota, D., Wsólová, L., Dzian, A., & Mistuna, D. (2014) · Open Medicine · doi:10.2478/s11536-013-0300-4 · Cited by 6 · see citing works
Les deux visages de p63, Janus de la famille p53
de Fromentel, C. C., Aberdam, É., & Aberdam, D. (2012) · médecine/sciences · doi:10.1051/medsci/2012284015 · Cited by 5 · see citing works
Bi, Y.-H., Wang, J., Guo, Z., & Jia, K. (2022) · Journal of Pain Research · doi:10.2147/jpr.s385228 · Cited by 5 · see citing works
Atox1-cyclin D1 loop activity is critical for survival of tumor cells with inactivated TP53
Kuchur, O. A., Pogodaeva, S. S., Shcherbakova, A. V., & Tsymbal, S. A. (2024) · Bioscience Reports · doi:10.1042/bsr20240389 · Cited by 5 · see citing works
Family matters: sibling rivalry and bonding between p53 and p63 in cancer
Romano, R., & Sinha, S. (2014) · Experimental Dermatology · doi:10.1111/exd.12356 · Cited by 5 · see citing works
Reddy, V. R., Annamalai, T., Narayanan, V., & Ramanathan, A. (2015) · Asian Pacific Journal of Cancer Prevention · doi:10.7314/apjcp.2015.16.4.1599 · Cited by 5 · see citing works
Lucchesi, C. A., Zhang, J., Vasilatis, D. M., Yip, E., & Chen, X. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.893062 · Cited by 5 · see citing works
Association Between TP53 Mutation and Prognosis in Wilms Tumor: A Meta-Analysis
Li, L., Rongdong, H., He, S., Yingquan, K., Xu, H., Lin, S., Tang, K., & Xu, D. (2020) · Fetal and Pediatric Pathology · doi:10.1080/15513815.2020.1725937 · Cited by 5 · see citing works
Status of p53 and p27KIP1 in Iranian Patients With Oral Squamous Cell Carcinoma
Etemad‐Moghadam, S., Keyhani, A., Yazdani, K., & Alaeddini, M. (2015) · Iranian Red Crescent Medical Journal · doi:10.5812/ircmj.19359 · Cited by 5 · see citing works
Fei, J.-W., & de Villiers, E. (2012) · PLoS ONE · doi:10.1371/journal.pone.0035540 · Cited by 4 · see citing works
Niknejad, A., Esmaealzadeh, N., Peyrovinasab, A., Sirouskabiri, S., Gholami, M., Pasha, A. V. K., Shahri, S., Büsselberg, D., & Abdolghaffari, A. H. (2025) · Phytotherapy Research · doi:10.1002/ptr.8522 · Cited by 3 · see citing works
Concurrent TP53 Mutation and Deletion in Refractory Low-grade Follicular Lymphoma
Khanlari, M., Wang, S. A., Fowler, N. H., Tang, G., Saluja, K., Muzzafar, T., Medeiros, L. J., & Thakral, B. (2021) · Clinical Lymphoma Myeloma & Leukemia · doi:10.1016/j.clml.2021.03.003 · Cited by 3 · see citing works
RETRACTED: UHRF2, another E3 ubiquitin ligase for p53
Bai, L., Wang, X., Jin, F., Yang, Y., Qian, G., & Duan, C. (2012) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2012.08.009 · Cited by 3 · see citing works
RetractedSun, Y., Myers, C. J., Dicker, A. P., & Lü, B. (2014) · PLoS ONE · doi:10.1371/journal.pone.0087492 · Cited by 3 · see citing works
Wasserman, J. K., AlGhamdi, D. A., de Almeida, J. R., Stockley, T. L., & Perez‐Ordoñez, B. (2018) · Head and Neck Pathology · doi:10.1007/s12105-018-0934-2 · Cited by 3 · see citing works
El-kott, A. F., ElBealy, E. R., Elsaid, F. G., El-Mekkawy, H. I., Abd-Lateif, A.-E.-K. M., Taweel, A., Khalifa, H. S., Kandeel, A. Y., Morsy, K., Ibrahim, E. H., et al. (2021) · Biocell · doi:10.32604/biocell.2021.012516 · Cited by 2 · see citing works
ANGEL2 Modulates Wild-type TP53 Translation and Doxorubicin Chemosensitivity in Colon Cancer
Lucchesi, C. A., Mantrala, S., Tran, D., Batra, N., Durve, A., Suen, C., Zhang, J., Ghosh, P., & Chen, X. (2025) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-24-0702 · Cited by 2 · see citing works
WITHDRAWN: MiR-200 family and cancer: Function, regulation and signaling
Chen, Y., & Zhang, L. (2014) · Surgical Oncology · doi:10.1016/j.suronc.2014.03.001 · Cited by 2 · see citing works
p53 as Batman: Using a Movie Plot to Understand Control of the Cell Cycle
Gadi, N., Foley, S. E., Nowey, M., & Plopper, G. E. (2013) · Science Signaling · doi:10.1126/scisignal.2003535 · Cited by 2 · see citing works
Rojas, M. L. (2011) · Digital Commons-TMC (Texas Medical Center) · Cited by 2 · see citing works
p53: Point Mutations, SNPs and Cancer
Fang, M., Simeonova, I., & Toledo, F. (2012) · InTech eBooks · doi:10.5772/33715 · Cited by 1 · see citing works
The Molecular Genetic Events in Colorectal Cancer and Diet
Naguib, A., Laura, J., Panagiota, N., & Mark, J. (2012) · InTech eBooks · doi:10.5772/29365
McEachin, R. C. (2011) · World Journal of Medical Genetics · doi:10.5496/wjmg.v1.i1.4
Regulation of Podosomes in Vascular Smooth Muscle Cell Invasion of the Extracellular Matrix
Mak, A. S. (2016) · WORLD SCIENTIFIC eBooks · doi:10.1142/9789813144064_0006
- Authors
- Aylon, Y., & Oren, M.
- Affiliations
- Weizmann Institute of Science (IL)
- Corresponding author
- Oren, Moshe
- Venue
- Current Opinion in Genetics & Development
- Publisher
- Elsevier BV
- Published
- 2011-02
- Volume
- 21
- Issue
- 1
- Pages
- 86-92
- ISSN
- 0959-437X (ISSN-L)
- PMC
- PMC3059112
- OpenAlex
- W1988733824
- Cited by
- 106
- References
- 63
- Citations by year
- 2025: 4 · 2024: 3 · 2023: 2 · 2022: 5 · 2021: 6 · 2020: 10 · 2019: 6 · 2018: 6 · 2017: 2 · 2016: 8 · 2015: 7 · 2014: 14 · 2013: 6 · 2012: 18
- FWCI
- 1.15
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Current Opinion in Genetics & Development (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (R37 CA40099, R37CA040099)
- Topics
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Keywords
- p53, p63, p73, tumor suppressor, transcription factors, non-coding RNA, RNA processing, tumor invasion, cellular metabolism, stem cell self-renewal
- MeSH terms
- Animals, Humans, Neoplasms, Stem Cells, Signal Transduction, Tumor Suppressor Protein p53, RNA, Untranslated
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
