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Puzzles, promises and a cure for ageing
Open accessAbstract
Recent discoveries in the science of ageing indicate that lifespan in model organisms such as yeast, nematodes, flies and mice is plastic and can be manipulated by genetic, nutritional or pharmacological intervention. A better understanding of the targets of such interventions, as well as the proximate causes of ageing-related degeneration and disease, is essential before we can evaluate if abrogation of human senescence is a realistic prospect.
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“The time-dependent accumulation of cellular damage is widely considered the general cause of aging (Gems and Partridge, 2013; Kirkwood, 2005; Vijg and Campisi, 2008).”
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“Although there is no scientific reason why such efforts could not be successful, the possibility is essentially constrained by the myriad of genetic variants that collectively determine species-specific lifespan16.”
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“These pathologies likely arise from a loss of tissue homeostasis driven by one or more basic aging process, together with stochastic, genetic, and environmental factors (Vijg and Campisi, 2008).”
BackgroundSelf-citation
Metadata
- Authors
- Vijg, J., & Campisi, J.
- Affiliations
- Buck Institute for Research on Aging (US)
- Corresponding author
- Vijg, Jan
- Campisi, Judith
- Venue
- Nature
- Published
- 2008-08
- Volume
- 454
- Issue
- 7208
- Pages
- 1065-1071
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC2774752
- OpenAlex
- W2006287843
- Cited by
- 407
- References
- 76
- Citations by year
- 2026: 6 · 2025: 14 · 2024: 10 · 2023: 14 · 2022: 19 · 2021: 20 · 2020: 16 · 2019: 21 · 2018: 14 · 2017: 14 · 2016: 23 · 2015: 28 · 2014: 24 · 2013: 32 · 2012: 31
- FWCI
- 3.47
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- National Institute on Aging (P30AG025708, P01AG017242)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Keywords
- aging, human lifespan, senescence, anti-aging interventions, model organisms, dietary intervention, pharmacological interventions, age-related diseases
- MeSH terms
- Aging, Animals, Disease, Biological Evolution, Humans, Life Expectancy, Longevity, Phenotype
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