Cited by 693Estrogen and related hormone effectsCancer Cells and MetastasisBreast Cancer Treatment Studies

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Control of mammary stem cell function by steroid hormone signalling

Asselin-Labat, Marie-Liesse, Vaillant, François, Sheridan, Julie M., Pal, Bhupinder, Wu, Di, Simpson, Evan R., Yasuda, Hisataka, Smyth, Gordon K., Martin, T. John, Lindeman, Geoffrey J., Visvader, Jane E.·2010·Nature

DOI 10.1038/nature09027

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Abstract

The ovarian hormones oestrogen and progesterone profoundly influence breast cancer risk, underpinning the benefit of endocrine therapies in the treatment of breast cancer. Modulation of their effects through ovarian ablation or chemoprevention strategies also significantly decreases breast cancer incidence. Conversely, there is an increased risk of breast cancer associated with pregnancy in the short term. The cellular mechanisms underlying these observations, however, are poorly defined. Here we demonstrate that mouse mammary stem cells (MaSCs) are highly responsive to steroid hormone signalling, despite lacking the oestrogen and progesterone receptors. Ovariectomy markedly diminished MaSC number and outgrowth potential in vivo, whereas MaSC activity increased in mice treated with oestrogen plus progesterone. Notably, even three weeks of treatment with the aromatase inhibitor letrozole was sufficient to reduce the MaSC pool. In contrast, pregnancy led to a transient 11-fold increase in MaSC numbers, probably mediated through paracrine signalling from RANK ligand. The augmented MaSC pool indicates a cellular basis for the short-term increase in breast cancer incidence that accompanies pregnancy. These findings further indicate that breast cancer chemoprevention may be achieved, in part, through suppression of MaSC function.

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Background
Progesterone regulation of stem and progenitor cells in normal and malignant breast
Axlund, S. D., & Sartorius, C. A. (2011) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.09.021 · Cited by 57
“Whereas paracrine signaling appears to be an important mechanism in progesterone-driven expansion and modulation of MaSCs in rodent mammary glands (Asselin-Labat et al., 2010; Gonzalez-Suarez et al., 2010; Joshi et al., 2010; Kariagina et al., 2010a; Schramek et al., 2010), and possibly the human breast (judging by th…”
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Beyond the Niche: Tissue-Level Coordination of Stem Cell Dynamics
O’Brien, L. E., & Bilder, D. H. (2013) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-101512-122319 · Cited by 60
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Zhao, C., Cai, S., Shin, K., Lim, A. Y.-L., Tomer Kalisky, C., Lu, W.-J., Clarke, M. F., & Beachy, P. A. (2017) · Science · doi:10.1126/science.aal3485 · Cited by 55
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Background
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Casey, A. E., Sinha, A., Singhania, R., Livingstone, J. M., Waterhouse, P. D., Tharmapalan, P., Cruickshank, J., Shehata, M., Drysdale, E., Fang, H., et al. (2018) · The Journal of Cell Biology · doi:10.1083/jcb.201804042 · Cited by 54
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“Furthermore, progesterone stimulation has been shown to promote mammary epithelial proliferation by activation of RANKL in mice [21, 62].”
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Background
Hypoxia induces RANK and RANKL expression by activating HIF-1α in breast cancer cells
Tang, Z.-N., Zhang, F., Tang, P., Qi, X., & Jiang, J. (2011) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2011.04.035 · Cited by 49
“Although the expression of RANK and RANKL in mammary epithelial cells has been shown to be influenced by prolactin [10] and ovarian hormones [11,12], less is known about the mecha-”
Background
RANKL expression in normal and malignant breast tissue responds to progesterone and is up-regulated during the luteal phase
Hu, H., Wang, J., Gupta, A., Shidfar, A., Branstetter, D. G., Lee, O., Ivancic, D. Z., Sullivan, M. E., Chatterton, R. T., Dougall, W. C., et al. (2014) · Breast Cancer Research and Treatment · doi:10.1007/s10549-014-3049-9 · Cited by 49
“Samples with adequate RNA quality (RNA integrity number RIN [8) were selected for further analysis.”
BackgroundMethod
Concise Review: Breast Cancer Stem Cells: Regulatory Networks, Stem Cell Niches, and Disease Relevance
Guo, W. (2014) · Stem Cells Translational Medicine · doi:10.5966/sctm.2014-0020 · Cited by 52
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“To explore whether this developmental function for αvβ3 in activated MaSCs may be related to its (21, 22) and highlight the coexpression of αvβ3 and Slug as markers of activated MaSCs.”
Background
Motherhood after breast cancer: searching for la dolce vita
Azim, H. A., Peccatori, F. A., de Azambuja, E., & Piccart, M. J. (2011) · Expert Review of Anticancer Therapy · doi:10.1586/era.10.208 · Cited by 48
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Background
A positive cross-regulation of HER2 and ER-α36 controls ALDH1 positive breast cancer cells
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Background
The WNT-controlled transcriptional regulator LBH is required for mammary stem cell expansion and maintenance of the basal lineage
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BackgroundInfluential
Progesterone and estrogen receptors segregate into different cell subpopulations in the normal human breast
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“For instance, in mammals, hematopoietic stem cells, mammary stem cells, muscle stem cells, and neural stem cells are influenced by sex hormones such as estrogen (Asselin-Labat et al., 2010; Bramble et al., 2019; Kim et al., 2016; Nakada et al., 2014).”
Background
Follicle-stimulating hormone inhibits apoptosis in ovarian cancer cells by regulating the OCT4 stem cell signaling pathway
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“In addition, hormones, such as estrogen and progesterone can augment mammary stem cells, which profoundly influence breast cancer risk (11,12).”
Background
Duration of tamoxifen use and the risk of contralateral breast cancer in BRCA1 and BRCA2 mutation carriers
Gronwald, J., Robidoux, A., Kim‐Sing, C., Tung, N., Lynch, H. T., Foulkes, W. D., Manoukian, S., Ainsworth, P., Neuhausen, S. L., Demsky, R., et al. (2014) · Breast Cancer Research and Treatment · doi:10.1007/s10549-014-3026-3 · Cited by 44
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From the ranks of mammary progesterone mediators, RANKL takes the spotlight
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“…of ER and PR expression (Asselin-Labat et al., 2006) and resides in the myoepithelial/basal compartment rather than in the luminal epithelium (Asselin-Labat et al., 2010; Joshi et al., 2010) frames this question in more specific terms: Does the MaSC represent a distinct responder cell for…”
BackgroundInfluential
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Obesity reversibly depletes the basal cell population and enhances mammary epithelial cell estrogen receptor alpha expression and progenitor activity
Chamberlin, T., D’Amato, J. V., & Arendt, L. M. (2017) · Breast Cancer Research · doi:10.1186/s13058-017-0921-7 · Cited by 43
“Since we observed changes in the luminal to basal/ myoepithelial cell ratios and luminal epithelial cell populations in human breast tissue using flow cytometry, we examined expression of the luminal cell marker ERα, which is enriched in the mature luminal cell population in mice and humans [18, 19, 41, 46, 47].”
The Proto-Oncogene Myc Is Essential for Mammary Stem Cell Function
Moumen, M., Chiche, A., Deugnier, M., Petit, V., Gandarillas, A., Glukhova, M. A., & Faraldo, M. M. (2012) · Stem Cells · doi:10.1002/stem.1090 · Cited by 44
Pubertal Bisphenol A Exposure Alters Murine Mammary Stem Cell Function Leading to Early Neoplasia in Regenerated Glands
Wang, D., Gao, H., Bandyopadhyay, A. M., Wu, A., Yeh, I., Chen, Y., Zou, Y., Huang, C., Walter, C. A., Dong, Q., et al. (2014) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-13-0260 · Cited by 45
“induced changes such as increased TEBs, prolonged diestrus stage, and increased progesterone receptor (PR) expression have all been linked to the induction of MaSC expansion (39, 42).”
Identification of novel human receptor activator of nuclear factor-kB isoforms generated through alternative splicing: implications in breast cancer cell survival and migration
Papanastasiou, A. D., Sirinian, C., & Kalofonos, H. P. (2012) · Breast Cancer Research · doi:10.1186/bcr3234 · Cited by 41
“The upregulation of the TNFRSF11A_Δ7,8,9 variant observed in breast cancer tissues may reflect either major changes in the mammary cell compartment at the molecular level [4,39] and/or changes in the tumor microenvironment, such as immune cell infiltration (T cells, macrophages, and so on) [39], occurring from early s…”
Background
Prolactin suppresses a progestin-induced CK5-positive cell population in luminal breast cancer through inhibition of progestin-driven BCL6 expression
Sato, T., Tran, T. H., Peck, A. R., Girondo, M. A., Liu, C., Goodman, C. R., Neilson, L. M., Freydin, B., Chervoneva, I., Hyslop, T., et al. (2013) · Oncogene · doi:10.1038/onc.2013.172 · Cited by 41
“Intriguingly, recent studies have demonstrated progesterone-induced up-regulation of mammary epithelial stem cells in mice (41, 42), raising the possibility that some luminal breast cancers exploit progesterone receptor signaling to up-regulate stem cell populations.”
Active allies: hormones, stem cells and the niche in adult mammopoiesis
Joshi, P. A., Grappa, M. A. D., & Khokha, R. (2012) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2012.04.002 · Cited by 42
Stem Cells as Hormone Targets That Lead to Increased Cancer Susceptibility
Prins, G. S., Calderon-Gierszal, E. L., & Hu, W.-Y. (2015) · Endocrinology · doi:10.1210/en.2015-1357 · Cited by 41
Ubiquitin ligase RNF8 suppresses Notch signaling to regulate mammary development and tumorigenesis
Li, L., Guturi, K. K. N., Gautreau, B., Patel, P. S., Saad, A., Morii, M., Mateo, F., Palomero, L., Barbour, H., Gómez, A., et al. (2018) · Journal of Clinical Investigation · doi:10.1172/jci120401 · Cited by 41
Birth Weight, Breast Cancer and the Potential Mediating Hormonal Environment
Bukowski, R. K., Chlebowski, R. T., Thune, I., Furberg, A.-S., Hankins, G. D. V., Malone, F. D., & D’Alton, M. E. (2012) · PLoS ONE · doi:10.1371/journal.pone.0040199 · Cited by 41
“Recently, preclinical studies have suggested that breast stem cells population may expand or contract, retaining a ‘‘memory’’ of prior hormone exposure [46] providing a potential mechanism for long term effects on breast cancer risk of such exposures during pregnancy.”
Background
Embryonic cells contribute directly to the quiescent stem cell population in the adult mouse mammary gland
Boras-Granic, K., Dann, P. R., & Wysolmerski, J. J. (2014) · Breast Cancer Research · doi:10.1186/s13058-014-0487-6 · Cited by 42
“Furthermore, it has been shown that MaSCs are hormonally regulated and proliferate in response to estrogen and progesterone [34,35].”
Background
Micronized progesterone and its impact on the endometrium and breast vs. progestogens
Gompel, A. (2012) · Climacteric · doi:10.3109/13697137.2012.669584 · Cited by 40
The development of denosumab for the treatment of diseases of bone loss and cancer‐induced bone destruction
Goessl, C. D., Katz, L., Dougall, W. C., Kostenuik, P. J., Zoog, H. B., Braun, A., Dansey, R., & Wagman, R. B. (2012) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2012.06674.x · Cited by 40
Dual roles for Id4 in the regulation of estrogen signaling in the mammary gland and ovary
Best, S. A., Hutt, K. J., Fu, N. Y., Vaillant, F., Liew, S. H., Hartley, L., Scott, C. L., Lindeman, G. J., & Visvader, J. E. (2014) · Development · doi:10.1242/dev.108498 · Cited by 38
“Indeed, MaSCs from ovariectomized females show significantly reduced activity (Asselin-Labat et al., 2010).”
Background
Efficient drug delivery of β-estradiol encapsulated in Zn-metal–organic framework nanostructures by microwave-assisted coprecipitation method
Ranjbar, M., Pardakhty, A., Amanatfard, A., & Asadipour, A. (2018) · Drug Design Development and Therapy · doi:10.2147/dddt.s173324 · Cited by 40
Response of Estrogen Receptor-Positive Breast Cancer Tumorspheres to Antiestrogen Treatments
Ao, A. S., Morrison, B. J., Wang, H., López, J. A., Reynolds, B. A., & Lu, J. (2011) · PLoS ONE · doi:10.1371/journal.pone.0018810 · Cited by 39
Novel Insight into KLF4 Proteolytic Regulation in Estrogen Receptor Signaling and Breast Carcinogenesis
Hu, D. G., Zhou, Z., Davidson, N. E., Huang, Y., & Wan, Y. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.343566 · Cited by 39
“Most recent studies suggest that estrogen is involved in the control of mammary stem cell function, including number and regenerative activity (63, 64).”
Background
Mammospheres from murine mammary stem cell-enriched basal cells: Clonal characteristics and repopulating potential
Dong, Q., Wang, D., Bandyopadhyay, A. M., Gao, H., Gorena, K. M., Hildreth, K., Rebel, V. I., Walter, C. A., Huang, C., & Sun, L. (2013) · Stem Cell Research · doi:10.1016/j.scr.2013.01.007 · Cited by 38
“Thus, our SFD assay recapitulated the difference in MaSC numbers between virgin and pregnant mice (Asselin-Labat et al., 2010), even though the magnitude of the difference was much lower.”
BackgroundMethodInfluential
Progestin effects on cell proliferation pathways in the postmenopausal mammary gland
Wood, C. E., Branstetter, D. G., Jacob, A. P., Cline, J. M., Register, T. C., Rohrbach, K., Huang, L., Borgerink, H. M., & Dougall, W. C. (2013) · Breast Cancer Research · doi:10.1186/bcr3456 · Cited by 38
“…have shown that RANKL is an essential paracrine mediator of progesterone function in the mouse mammary gland, leading to both mammary epithelial proliferation [43] and the transient expansion and increased regenerative potential of mammary stem cells [44,45] during pregnancy and the estrous cycle.”
Minireview: Progesterone Regulation of Proliferation in the Normal Human Breast and in Breast Cancer: A Tale of Two Scenarios?
Hilton, H. N., Graham, J. D., & Clarke, C. L. (2015) · Molecular Endocrinology · doi:10.1210/me.2015-1152 · Cited by 39
“Data derived from mouse models and using fluorescence-activated cell sorting-based approaches have also shown that P stimulates the MaSC compartment, specifically during pregnancy as well as during the luteal dioestrous phase of the reproductive cycle, a mechanism suggested to account for the increased window of susce…”
BackgroundMethod
14-3-3 σ: A potential biomolecule for cancer therapy
Huang, Y., Yang, M., & Huang, W. (2020) · Clinica Chimica Acta · doi:10.1016/j.cca.2020.09.009 · Cited by 39
Proliferative heterogeneity of murine epithelial cells in the adult mammary gland
Shehata, M., Waterhouse, P. D., Casey, A. E., Fang, H., Hazelwood, L. D., & Khokha, R. (2018) · Communications Biology · doi:10.1038/s42003-018-0114-7 · Cited by 38
Poor prognosis of patients with triple-negative breast cancer can be stratified by RANK and RANKL dual expression
Reyes, M. E., Fujii, T., Branstetter, D. G., Krishnamurthy, S., Masuda, H., Wang, X., Reuben, J. M., Woodward, W. A., Edwards, B. J.-A., Hortobágyi, G. N., et al. (2017) · Breast Cancer Research and Treatment · doi:10.1007/s10549-017-4233-5 · Cited by 38
The Nuclear Factor-Kappa B Pathway and Response to Treatment in Breast Cancer
Park, Y. H. (2017) · Pharmacogenomics · doi:10.2217/pgs-2017-0044 · Cited by 38
Elf5, hormones and cell fate
Lee, H. J., & Ormandy, C. J. (2012) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2012.02.006 · Cited by 38
Hormonal Control of Stem Cell Systems
Gancz, D., & Gilboa, L. (2013) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-101512-122331 · Cited by 37
Plasma osteoprotegerin and breast cancer risk in BRCA1 and BRCA2 mutation carriers
Odén, L., Akbari, M. R., Zaman, T., Singer, C. F., Sun, P., Narod, S. A., Salmena, L., & Kotsopoulos, J. (2016) · Oncotarget · doi:10.18632/oncotarget.13417 · Cited by 37
Cytokine chemokine network in tumor microenvironment: Impact on CSC properties and therapeutic applications
Nengroo, M. A., Verma, A., & Datta, D. B. (2022) · Cytokine · doi:10.1016/j.cyto.2022.155916 · Cited by 39
Aging is associated with an expansion of CD49fhi mammary stem cells that show a decline in function and increased transformation potential
Dong, Q., Gao, H., Shi, Y., Zhang, F., Gu, X., Wu, A., Wang, D., Chen, Y., Bandyopadhyay, A., Yeh, I.-T., et al. (2016) · Aging · doi:10.18632/aging.101082 · Cited by 29
“MaSCs and increased tertiary branching in aged glands phenocopy mammary glands at diestrus of the estrus cycle and those at pregnancy [19, 43].”
Endocrine disruptor chlorpyrifos promotes migration, invasion, and stemness phenotype in 3D cultures of breast cancer cells and induces a wide range of pathways involved in cancer progression
Lasagna, M., Ventura, C., Hielpos, M. S., Mardirosian, M. N., Martín, G., Miret, N. V., Randi, A. S., Núñez, M., & Cocca, C. (2021) · Environmental Research · doi:10.1016/j.envres.2021.111989 · Cited by 36
Investigating core genetic-and-epigenetic cell cycle networks for stemness and carcinogenic mechanisms, and cancer drug design using big database mining and genome-wide next-generation sequencing data
Li, C., & Chen, B. (2016) · Cell Cycle · doi:10.1080/15384101.2016.1198862 · Cited by 36
“It has been demonstrated that mammary stem cells are highly responsive to steroid hormone signaling.(78) One of the earliest changes in gene expression affecting the steroid hormone-mediated signaling pathway in response to a differentiation signal has been observed in mammary stem cells, supporting our findings.”
Result
Steroid Hormones and the Physiological Regulation of Tissue-Resident Stem Cells: Lessons from the Drosophila Ovary
Ables, E. T., & Drummond‐Barbosa, D. (2017) · Current Stem Cell Reports · doi:10.1007/s40778-017-0070-z · Cited by 37
Breast cancer stem cells: the role of sex steroid receptors
Giovannelli, P., Donato, M. D., Galasso, G., Zazzo, E. D., Medici, N., Bilancio, A., Migliaccio, A., & Castoria, G. (2019) · World Journal of Stem Cells · doi:10.4252/wjsc.v11.i9.594 · Cited by 36
The unique transcriptional response produced by concurrent estrogen and progesterone treatment in breast cancer cells results in upregulation of growth factor pathways and switching from a Luminal A to a Basal-like subtype
Need, E. F., Selth, L. A., Trotta, A. P., Leach, D. A., Giorgio, L., O'Loughlin, M. A., Smith, E., Gill, P. G., Ingman, W. V., Graham, J. D., et al. (2015) · BMC Cancer · doi:10.1186/s12885-015-1819-3 · Cited by 34
“More recently PR is emerging as a key mediator of normal mammary gland development and tumorigenesis in mice, promoting mammary stem cell expansion and directing the immune microenvironment [5–10].”
Background
An Immunohistochemical Method to Study Breast Cancer Cell Subpopulations and Their Growth Regulation by Hormones in Three-Dimensional Cultures
Pinto, M. P., Jacobsen, B. M., & Horwitz, K. B. (2011) · Frontiers in Endocrinology · doi:10.3389/fendo.2011.00015 · Cited by 36
Use of a MCL-1 inhibitor alone to de-bulk melanoma and in combination to kill melanoma initiating cells
Mukherjee, N., Lü, Y., Almeida, A. R., Lambert, K. A., Shiau, C., Su, J.-C., Luo, Y., Fujita, M., Robinson, W. A., Robinson, S. E., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.8695 · Cited by 37
“Data for tumor incidence was analyzed using ELDA software (WEHI bioinformatic resources) and significance was determined by chi-square analysis as described in [93, 94].”
Method
Generation of Induced Pluripotent Stem Cells from Bovine Epithelial Cells and Partial Redirection Toward a Mammary Phenotype In Vitro
Cravero, D., Martignani, E., Miretti, S., Accornero, P., Pauciullo, A., Sharma, R., Donadeu, F. X., & Baratta, M. (2015) · Cellular Reprogramming · doi:10.1089/cell.2014.0087 · Cited by 35
“In fact, ovariectomy markedly diminished the mammary stem cell number and outgrowth potential in vivo , whereas stem cell activity increased in mice treated with estrogen plus progesterone (Asselin-Labat et al., 2010).”
Rankl Impairs Lactogenic Differentiation Through Inhibition of the Prolactin/Stat5 Pathway at Midgestation
Cordero, Á., Pellegrini, P., Sanz‐Moreno, A., Trinidad, E. M., Serra-Musach, J., Deshpande, C., Dougall, W. C., Pujana, M. Á., & González‐Suárez, E. (2015) · Stem Cells · doi:10.1002/stem.2271 · Cited by 35
Breast cancer in pregnant patients: A review of the literature
Martínez, M. T., Bermejo, B., Hernándo, C., Gambardella, V., Cejalvo, J. M., & Lluch, A. M. (2018) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2018.04.029 · Cited by 35
Mechanosensitive hormone signaling promotes mammary progenitor expansion and breast cancer risk
Northey, J. J., Hayward, M.-K., Yui, Y., Stashko, C., Kai, F., Mouw, J. K., Thakar, D., Lakins, J. N., Ironside, A. J., Samson, S. M., et al. (2024) · Cell stem cell · doi:10.1016/j.stem.2023.12.002 · Cited by 36
The role of steroid hormones in breast cancer stem cells
Simões, B. M., Alférez, D., Howell, S. J., & Clarke, R. B. (2015) · Endocrine Related Cancer · doi:10.1530/erc-15-0350 · Cited by 35
“Studies in mice have shown that mammary gland development results from progesterone-induced expansion of the mam- mary stem cell pool and have also shown that PR is important for carcinogen-induced mammary tumor for- mation (Lydon et al. 1999, Asselin-Labat et al. 2010, Joshi et al. 2010).”
Background

Authors: Asselin-Labat, M.-L., Vaillant, F., Sheridan, J. M., Pal, B., Wu, D., Simpson, E. R., Yasuda, H., Smyth, G. K., Martin, T. J., Lindeman, G. J., & Visvader, J. E.
Affiliations: Walter and Eliza Hall Institute of Medical Research (AU)
The University of Melbourne (AU)
Monash Medical Centre (AU)
Oriental Yeast Co., Ltd. (Japan) (JP)
St Vincents Institute of Medical Research (AU)
The Royal Melbourne Hospital (AU)
Corresponding author: Lindeman, Geoffrey J.
Visvader, Jane E.
ORCID: Asselin-Labat, Marie-Liesse
Vaillant, François
Sheridan, Julie M.
Pal, Bhupinder
Wu, Di
Simpson, Evan R.
Yasuda, Hisataka
Smyth, Gordon K.
Lindeman, Geoffrey J.
Visvader, Jane E.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2010-04-11
Volume: 465
Issue: 7299
Pages: 798-802
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature09027
OpenAlex: W2117963341
Cited by: 693
References: 38
Citations by year: 2026: 8 · 2025: 16 · 2024: 29 · 2023: 22 · 2022: 29 · 2021: 30 · 2020: 30 · 2019: 32 · 2018: 40 · 2017: 44 · 2016: 45 · 2015: 63 · 2014: 53 · 2013: 64 · 2012: 76
FWCI: 45.37
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Breast Cancer Treatment Studies
Keywords: mammary stem cells, steroid hormone signaling, estrogen, progesterone, RANKL, breast cancer risk, pregnancy, ovariectomy, letrozole, aromatase inhibition, chemoprevention, paracrine signaling, mammary gland development
MeSH terms: Letrozole, Animals, Aromatase, Cell Count, Estrogens, Female, Humans, Mammary Glands, Animal, Nitriles, Ovariectomy, Pregnancy, Pregnancy, Animal, Progesterone, Receptors, Estrogen, Receptors, Progesterone, Stem Cells, Triazoles, Signal Transduction, Integrin beta1, Paracrine Communication, Integrin beta3, Aromatase Inhibitors, Mice, CD24 Antigen, RANK Ligand, ErbB Receptors

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Control of mammary stem cell function by steroid hormone signalling

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