Cited by 693Estrogen and related hormone effectsCancer Cells and MetastasisBreast Cancer Treatment Studies

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Control of mammary stem cell function by steroid hormone signalling

Asselin-Labat, Marie-Liesse, Vaillant, François, Sheridan, Julie M., Pal, Bhupinder, Wu, Di, Simpson, Evan R., Yasuda, Hisataka, Smyth, Gordon K., Martin, T. John, Lindeman, Geoffrey J., Visvader, Jane E.·2010·Nature

DOI 10.1038/nature09027

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Abstract

The ovarian hormones oestrogen and progesterone profoundly influence breast cancer risk, underpinning the benefit of endocrine therapies in the treatment of breast cancer. Modulation of their effects through ovarian ablation or chemoprevention strategies also significantly decreases breast cancer incidence. Conversely, there is an increased risk of breast cancer associated with pregnancy in the short term. The cellular mechanisms underlying these observations, however, are poorly defined. Here we demonstrate that mouse mammary stem cells (MaSCs) are highly responsive to steroid hormone signalling, despite lacking the oestrogen and progesterone receptors. Ovariectomy markedly diminished MaSC number and outgrowth potential in vivo, whereas MaSC activity increased in mice treated with oestrogen plus progesterone. Notably, even three weeks of treatment with the aromatase inhibitor letrozole was sufficient to reduce the MaSC pool. In contrast, pregnancy led to a transient 11-fold increase in MaSC numbers, probably mediated through paracrine signalling from RANK ligand. The augmented MaSC pool indicates a cellular basis for the short-term increase in breast cancer incidence that accompanies pregnancy. These findings further indicate that breast cancer chemoprevention may be achieved, in part, through suppression of MaSC function.

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Gentleman, R. C., Carey, V. J., Bates, D. M., Bolstad, B., Dettling, M., Dudoit, S., Ellis, B., Gautier, L., Ge, Y., Gentry, J., et al. (2004) · Genome biology · doi:10.1186/gb-2004-5-10-r80 · Cited by 12,082
Linear Models and Empirical Bayes Methods for Assessing Differential Expression in Microarray Experiments
Smyth, G. K. (2004) · Statistical Applications in Genetics and Molecular Biology · doi:10.2202/1544-6115.1027 · Cited by 11,829
Self-citation
Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials
(2005) · The Lancet · doi:10.1016/s0140-6736(05)66544-0 · Cited by 7,626
In vitro propagation and transcriptional profiling of human mammary stem/progenitor cellsPreprint
Dontu, G., Abdallah, W. M., Foley, J. M., Jackson, K. W., Clarke, M. F., Kawamura, M., & Wicha, M. S. (2003) · Genes & Development · doi:10.1101/gad.1061803 · Cited by 2,413
ELDA: Extreme limiting dilution analysis for comparing depleted and enriched populations in stem cell and other assays
Hu, Y., & Smyth, G. K. (2009) · Journal of Immunological Methods · doi:10.1016/j.jim.2009.06.008 · Cited by 2,084
Generation of a functional mammary gland from a single stem cell
Shackleton, M., Vaillant, F., Simpson, K. J., Stingl, J., Smyth, G. K., Asselin-Labat, M.-L., Wu, L., Lindeman, G. J., & Visvader, J. E. (2006) · Nature · doi:10.1038/nature04372 · Cited by 2,005
Self-citation
Mice lacking progesterone receptor exhibit pleiotropic reproductive abnormalities.Preprint
Lydon, J. P., DeMayo, F. J., Funk, C. R., Mani, S. K., Hughes, A. R., Montgomery, C. A., Shyamala, G., Conneely, O. M., & O’Malley, B. W. (1995) · Genes & Development · doi:10.1101/gad.9.18.2266 · Cited by 1,862
Effect of anastrozole and tamoxifen as adjuvant treatment for early-stage breast cancer: 10-year analysis of the ATAC trial
Cuzick, J., Sestak, I., Baum, M., Buzdar, A., Howell, A., Dowsett, M., & Forbes, J. F. (2010) · The Lancet Oncology · doi:10.1016/s1470-2045(10)70257-6 · Cited by 1,674
Purification and unique properties of mammary epithelial stem cells
Stingl, J., Eirew, P. D., Ricketson, I., Shackleton, M. J., Vaillant, F., Choi, D., Li, H. I., & Eaves, C. J. (2006) · Nature · doi:10.1038/nature04496 · Cited by 1,581
Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers
kConFab, Lim, E., Vaillant, F., Wu, D., Forrest, N. C., Pal, B., Hart, A. H., Asselin-Labat, M.-L., Gyorki, D. E., Ward, T., et al. (2009) · Nature Medicine · doi:10.1038/nm.2000 · Cited by 1,492

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Breast Cancer Risk: Role of Somatic Breast Stem Cells
Eden, J. (2011) · Springer eBooks · doi:10.1007/978-94-007-2016-9_24
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Park, S. (2011) · Illinois Digital Environment for Access to Learning and Scholarship (University of Illinois at Urbana-Champaign)
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Catalano, F., Scandurra, G., Ravalli, C., Fraggetta, F., & Catanuto, G. (2014) · Updates in surgery/Updates in surgery series · doi:10.1007/978-88-470-5438-7_10
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“An increase in proliferation coupled with alterations to the hormone receptor status in the mammary gland may impact the MaSC population, as this population is hormone receptor negative [50, 51].”
Background
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Additional file 5 of Atypical cell cycle regulation promotes mammary stem cell expansion during mammary development and tumourigenesis
Fifield, B.-A., Vusich, J., Haberfellner, E., Andrechek, E. R., & Porter, L. A. (2024) · Figshare · doi:10.6084/m9.figshare.26740640
Additional file 1 of Atypical cell cycle regulation promotes mammary stem cell expansion during mammary development and tumourigenesis
Fifield, B.-A., Vusich, J., Haberfellner, E., Andrechek, E. R., & Porter, L. A. (2024) · Figshare · doi:10.6084/m9.figshare.26129656
Additional file 7 of Atypical cell cycle regulation promotes mammary stem cell expansion during mammary development and tumourigenesis
Fifield, B.-A., Vusich, J., Haberfellner, E., Andrechek, E. R., & Porter, L. A. (2024) · Figshare · doi:10.6084/m9.figshare.26740646
Additional file 6 of Atypical cell cycle regulation promotes mammary stem cell expansion during mammary development and tumourigenesis
Fifield, B.-A., Vusich, J., Haberfellner, E., Andrechek, E. R., & Porter, L. A. (2024) · Figshare · doi:10.6084/m9.figshare.26740643
Additional file 10 of Atypical cell cycle regulation promotes mammary stem cell expansion during mammary development and tumourigenesis
Fifield, B.-A., Vusich, J., Haberfellner, E., Andrechek, E. R., & Porter, L. A. (2024) · Figshare · doi:10.6084/m9.figshare.26740655
Additional file 1 of Postdiagnosis circulating osteoprotegerin and TRAIL concentrations and survival and recurrence after a breast cancer diagnosis: results from the MARIE patient cohort
Cornet, C. L., Jung, A. Y., Johnson, T., Behrens, S., Obi, N., Becher, H., Chang-Claude, J., & Fortner, R. T. (2023) · Figshare · doi:10.6084/m9.figshare.22649158
Additional file 1 of Progesterone receptor antagonists reverse stem cell expansion and the paracrine effectors of progesterone action in the mouse mammary gland
Ranjan, M., Lee, O., Cottone, G., Mehrabad, E. M., Spike, B. T., Zeng, Z., Yadav, S., Chatterton, R. T., Kim, J. J., Clare, S. E., et al. (2021) · Figshare · doi:10.6084/m9.figshare.15102511
Additional file 3 of Atypical cell cycle regulation promotes mammary stem cell expansion during mammary development and tumourigenesis
Fifield, B.-A., Vusich, J., Haberfellner, E., Andrechek, E. R., & Porter, L. A. (2024) · Figshare · doi:10.6084/m9.figshare.26740634
Additional file 4 of Atypical cell cycle regulation promotes mammary stem cell expansion during mammary development and tumourigenesis
Fifield, B.-A., Vusich, J., Haberfellner, E., Andrechek, E. R., & Porter, L. A. (2024) · Figshare · doi:10.6084/m9.figshare.26740637
Additional file 6 of Progesterone receptor antagonists reverse stem cell expansion and the paracrine effectors of progesterone action in the mouse mammary gland
Ranjan, M., Lee, O., Cottone, G., Mehrabad, E. M., Spike, B. T., Zeng, Z., Yadav, S., Chatterton, R. T., Kim, J. J., Clare, S. E., et al. (2021) · Figshare · doi:10.6084/m9.figshare.15102538
Additional file 12 of Atypical cell cycle regulation promotes mammary stem cell expansion during mammary development and tumourigenesis
Fifield, B.-A., Vusich, J., Haberfellner, E., Andrechek, E. R., & Porter, L. A. (2024) · Figshare · doi:10.6084/m9.figshare.26740661
Additional file 2 of Progesterone receptor antagonists reverse stem cell expansion and the paracrine effectors of progesterone action in the mouse mammary gland
Ranjan, M., Lee, O., Cottone, G., Mehrabad, E. M., Spike, B. T., Zeng, Z., Yadav, S., Chatterton, R. T., Kim, J. J., Clare, S. E., et al. (2021) · Figshare · doi:10.6084/m9.figshare.15102526
Additional file 4 of Progesterone receptor antagonists reverse stem cell expansion and the paracrine effectors of progesterone action in the mouse mammary gland
Ranjan, M., Lee, O., Cottone, G., Mehrabad, E. M., Spike, B. T., Zeng, Z., Yadav, S., Chatterton, R. T., Kim, J. J., Clare, S. E., et al. (2021) · Figshare · doi:10.6084/m9.figshare.15102532
Additional file 8 of Atypical cell cycle regulation promotes mammary stem cell expansion during mammary development and tumourigenesis
Fifield, B.-A., Vusich, J., Haberfellner, E., Andrechek, E. R., & Porter, L. A. (2024) · Figshare · doi:10.6084/m9.figshare.26740649
Additional file 3 of Progesterone receptor antagonists reverse stem cell expansion and the paracrine effectors of progesterone action in the mouse mammary gland
Ranjan, M., Lee, O., Cottone, G., Mehrabad, E. M., Spike, B. T., Zeng, Z., Yadav, S., Chatterton, R. T., Kim, J. J., Clare, S. E., et al. (2021) · Figshare · doi:10.6084/m9.figshare.15102529
Additional file 9 of Atypical cell cycle regulation promotes mammary stem cell expansion during mammary development and tumourigenesis
Fifield, B.-A., Vusich, J., Haberfellner, E., Andrechek, E. R., & Porter, L. A. (2024) · Figshare · doi:10.6084/m9.figshare.26740652
Additional file 5 of Progesterone receptor antagonists reverse stem cell expansion and the paracrine effectors of progesterone action in the mouse mammary gland
Ranjan, M., Lee, O., Cottone, G., Mehrabad, E. M., Spike, B. T., Zeng, Z., Yadav, S., Chatterton, R. T., Kim, J. J., Clare, S. E., et al. (2021) · Figshare · doi:10.6084/m9.figshare.15102535
Additional file 2 of Atypical cell cycle regulation promotes mammary stem cell expansion during mammary development and tumourigenesis
Fifield, B.-A., Vusich, J., Haberfellner, E., Andrechek, E. R., & Porter, L. A. (2024) · Figshare · doi:10.6084/m9.figshare.26129821
Additional file 1 of Multiple roles for Bcl-3 in mammary gland branching, stromal collagen invasion, involution and tumor pathology
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Additional file 11 of Atypical cell cycle regulation promotes mammary stem cell expansion during mammary development and tumourigenesis
Fifield, B.-A., Vusich, J., Haberfellner, E., Andrechek, E. R., & Porter, L. A. (2024) · Figshare · doi:10.6084/m9.figshare.26740658
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TOX3 – A candidate breast cancer predisposition gene
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“Several recent studies have shown that progesterone signalling induces proliferation of MaSC as well as tumour cells in a paracrine fashion that is mediated by the osteoclast differentiation factor RANKL (Asselin-Labat et al., 2010; Beleut et al., 2010; Fernandez-Gonzalez et al., 2010; Joshi et al., 2010; Schramek et…”
Background
Régulation des cellules initiatrices de tumeurs dans le cancer colorectal par la Progastrine
Giraud, J. (2013) · theses.fr (ABES) · doi:10.70675/4e0f05c4z6aaez40faz89a5z451a3e609f9b
Régulation de l’érythropoïèse : rôle des récepteurs à la transferrine et d’un phytoestrogène
Fouquet, G. (2019) · theses.fr (ABES) · doi:10.70675/ea62edc1z4e80z4d30z8220zdc73652aa716
Rôle de la GTPase golgienne RAB6 dans la fonction du lignage sécrétoire mammaire
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Gagniac, L. (2018) · theses.fr (ABES) · doi:10.70675/e3a481e5z03b7z41dfzbf49z0c775cc06c86
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Bailleul, J. (2018) · theses.fr (ABES) · doi:10.70675/7b7ed1e6za3c1z4b91za502z4e457adadd45
Plasticité cellulaire et initiation tumorale dans le modèle du cancer du sein
Blander, H. D. (2020) · theses.fr (ABES) · doi:10.70675/c6b4eda8z19a5z4b3dzb7d9zacc5fd814b21
Dissection of nuclear and membrane actions of estrogen receptor ERalpha in murine reproduction : placental vascular physiology and ovarian function
Rusidzé, M. (2021) · theses.fr (ABES) · doi:10.70675/23689fd3z104dz430cz8aefzda827fddeddd
Population-associated molecular variation in histologically normal breast tissue is context-dependent and associated with distinct transcriptional statesPreprint
Hulsy, W. D., Salazar, K., Chalkia, D., Chavez, Y., Zhao, Y., Halkia, G., Razorenova, O. V., & Nikolaidis, N. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.06.16.732684
“Larger, deeply characterized, and cell-type-resolved studies will be required to determine whether these context-dependent differences have functional consequences for breast cancer susceptibility, tumor characteristics, progression, or population-associated disparities [1-9”
Single-cell multi-omic profiling of heterogeneous PROCR+ cells in mouse mammary gland and its implication for breast cancer
Yan, K., Nekritz, E. A., Xie, Z., Ju, B., Dong, X., Werner, R., Alsina‐Beauchamp, D., Rosencrance, C. D., Mukhopadhyay, P., Pan, Q., et al. (2026) · iScience · doi:10.1016/j.isci.2026.117410
Population-Associated Molecular Variation in Histologically Normal Breast Tissue Is Associated with Distinct Baseline Transcriptional States
Hulsy, W. D., Salazar, K., Chalkia, D., Chavez, Y., Zhao, Y., Halkia, G., Razorenova, O. V., & Nikolaidis, N. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27188279
Epithelial and mesenchymal stem cell biology in the mammary gland: mechanisms, comparative insights, and translational perspectives
Barash, I. (2026) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2026.1982804
Translating Mammary Stem Cell and Cancer Stem Cell Biology to the Clinics
Pathania, R., Ganapathy, V., & Thangaraju, M. (2011) · Springer eBooks · doi:10.1007/978-94-007-2801-1_19

Authors: Asselin-Labat, M.-L., Vaillant, F., Sheridan, J. M., Pal, B., Wu, D., Simpson, E. R., Yasuda, H., Smyth, G. K., Martin, T. J., Lindeman, G. J., & Visvader, J. E.
Affiliations: Walter and Eliza Hall Institute of Medical Research (AU)
The University of Melbourne (AU)
Monash Medical Centre (AU)
Oriental Yeast Co., Ltd. (Japan) (JP)
St Vincents Institute of Medical Research (AU)
The Royal Melbourne Hospital (AU)
Corresponding author: Lindeman, Geoffrey J.
Visvader, Jane E.
ORCID: Asselin-Labat, Marie-Liesse
Vaillant, François
Sheridan, Julie M.
Pal, Bhupinder
Wu, Di
Simpson, Evan R.
Yasuda, Hisataka
Smyth, Gordon K.
Lindeman, Geoffrey J.
Visvader, Jane E.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2010-04-11
Volume: 465
Issue: 7299
Pages: 798-802
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature09027
OpenAlex: W2117963341
Cited by: 693
References: 38
Citations by year: 2026: 8 · 2025: 16 · 2024: 29 · 2023: 22 · 2022: 29 · 2021: 30 · 2020: 30 · 2019: 32 · 2018: 40 · 2017: 44 · 2016: 45 · 2015: 63 · 2014: 53 · 2013: 64 · 2012: 76
FWCI: 45.37
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Breast Cancer Treatment Studies
Keywords: mammary stem cells, steroid hormone signaling, estrogen, progesterone, RANKL, breast cancer risk, pregnancy, ovariectomy, letrozole, aromatase inhibition, chemoprevention, paracrine signaling, mammary gland development
MeSH terms: Letrozole, Animals, Aromatase, Cell Count, Estrogens, Female, Humans, Mammary Glands, Animal, Nitriles, Ovariectomy, Pregnancy, Pregnancy, Animal, Progesterone, Receptors, Estrogen, Receptors, Progesterone, Stem Cells, Triazoles, Signal Transduction, Integrin beta1, Paracrine Communication, Integrin beta3, Aromatase Inhibitors, Mice, CD24 Antigen, RANK Ligand, ErbB Receptors

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Control of mammary stem cell function by steroid hormone signalling

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