TET1 and hydroxymethylcytosine in transcription and DNA methylation fidelity

Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1

Tahiliani, M., Koh, K. P., Shen, Y., Pastor, W. A., Bandukwala, H., Brudno, Y., Agarwal, S., Iyer, L. M., Liu, D. R., Aravind, L., et al. (2009) · Science · doi:10.1126/science.1170116 · Cited by 5,836

Genome-wide maps of chromatin state in pluripotent and lineage-committed cells

Mikkelsen, T. S., Ku, M., Jaffe, D. B., Issac, B., Lieberman, E., Giannoukos, G., Alvarez, P., Brockman, W., Kim, T.-K., Koche, R. P., et al. (2007) · Nature · doi:10.1038/nature06008 · Cited by 4,129

DNA methylation landscapes: Provocative insights from epigenomics

Suzuki, M. M., & Bird, A. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2341 · Cited by 3,039

The Nuclear DNA Base 5-Hydroxymethylcytosine Is Present in Purkinje Neurons and the Brain

Kriaucionis, S., & Heintz, N. (2009) · Science · doi:10.1126/science.1169786 · Cited by 2,700

Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification

Ito, S., D’Alessio, A. C., Taranova, O., Hong, K., Sowers, L. C., & Zhang, Y. (2010) · Nature · doi:10.1038/nature09303 · Cited by 2,628

Genome-scale DNA methylation maps of pluripotent and differentiated cells

Meissner, A., Mikkelsen, T. S., Gu, H., Wernig, M., Hanna, J., Sivachenko, A., Zhang, X., Bernstein, B. E., Nusbaum, C., Jaffe, D. B., et al. (2008) · Nature · doi:10.1038/nature07107 · Cited by 2,536

Linking DNA methylation and histone modification: patterns and paradigms

Cedar, H., & Bergman, Y. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2540 · Cited by 2,267

Chromosome-wide and promoter-specific analyses identify sites of differential DNA methylation in normal and transformed human cells

Weber, M., Davies, J. J., Wittig, D., Oakeley, E. J., Haase, M., Lam, W. L., & Schübeler, D. (2005) · Nature Genetics · doi:10.1038/ng1598 · Cited by 1,785

Mutation in TET2 in Myeloid Cancers

Delhommeau, F., Dupont, S., Valle, V. D., James, C., Trannoy, S., Massé, A., Kosmider, O., Le Couedic, J.-P., Robert, F., Alberdi, A., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0810069 · Cited by 1,776

Conserved role of intragenic DNA methylation in regulating alternative promoters

Maunakea, A. K., Nagarajan, R. P., Bilenky, M., Ballinger, T. J., D’Souza, C., Fouse, S. D., Johnson, B. E., Hong, C., Nielsen, C., Zhao, Y., et al. (2010) · Nature · doi:10.1038/nature09165 · Cited by 1,743

Epigenetic remodelling under hypoxia

Verdikt, R., & Thienpont, B. (2023) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2023.10.005 · Cited by 24

TET enzyme driven epigenetic reprogramming in early embryos and its implication on long-term health

Montgomery, T., Uh, K., & Lee, K. (2024) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2024.1358649 · Cited by 23

5-Formylcytosine is an activating epigenetic mark for RNA Pol III during zygotic reprogramming

Parasyraki, E., Mallick, M., Hatch, V., Vastolo, V., Musheev, M. U., Karaulanov, E., Gopanenko, A. V., Moxon, S., Méndez-Lago, M., Han, D., et al. (2024) · Cell · doi:10.1016/j.cell.2024.08.011 · Cited by 23

αα-Hub domains and intrinsically disordered proteins: A decisive combo

Bugge, K., Staby, L., Salladini, E., Falbe-Hansen, R. G., Kragelund, B. B., & Skriver, K. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.rev120.012928 · Cited by 23

MicroRNAs mediated targeting on the Yin-yang dynamics of DNA methylation in disease and development

Tu, J., Liao, J., Luk, A. C. S., Tang, N. L. S., Chan, W., & Lee, T. (2015) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2015.05.002 · Cited by 23

DNA Hydroxymethylation in Smoking-Associated Cancers

Nia, A. B., Caceres, A., & Tommasi, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23052657 · Cited by 25

G-quadruplexes Mark Sites of Methylation Instability Associated with Ageing and Cancer

Rauchhaus, J., Robinson, J., Monti, L., & Antonio, M. D. (2022) · Genes · doi:10.3390/genes13091665 · Cited by 23

Structure and Function of TET Enzymes

Yin, X., Hu, L., & Xu, Y. (2022) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-11454-0_10 · Cited by 24

Catalytic-dependent and -independent roles of TET3 in the regulation of specific genetic programs during neuroectoderm specification

Ketchum, H. C., Suzuki, M., & Dawlaty, M. M. (2024) · Communications Biology · doi:10.1038/s42003-024-06120-w · Cited by 23

TET family proteins: new players in gliomas

Bian, E., Zong, G., Xie, Y., Meng, X., Huang, C., Li, J., & Zhao, B. (2014) · Journal of Neuro-Oncology · doi:10.1007/s11060-013-1328-7 · Cited by 24

Developmental Functions of the Dynamic DNA Methylome and Hydroxymethylome in the Mouse and Zebrafish: Similarities and Differences

Jessop, P., Ruzov, A. S., & Gering, M. (2018) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2018.00027 · Cited by 23

The Role of Stochasticity in the Origin of Epigenetic Variation in Animal Populations

Biwer, C., Kawam, B., Chapelle, V., & Silvestre, F. (2020) · Integrative and Comparative Biology · doi:10.1093/icb/icaa047 · Cited by 25

Endonuclease G preferentially cleaves 5-hydroxymethylcytosine-modified DNA creating a substrate for recombination

Robertson, A. B., Robertson, J., Fußer, M., & Klungland, A. (2014) · Nucleic Acids Research · doi:10.1093/nar/gku1032 · Cited by 23

The extended pluripotency protein interactome and its links to reprogramming

Huang, X., & Wang, J. (2014) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2014.08.003 · Cited by 25

Endogenous epitope-tagging of Tet1, Tet2 and Tet3 identifies TET2 as a naïve pluripotency marker

Pantier, R., Tatar, T., Colby, D., & Chambers, I. (2019) · Life Science Alliance · doi:10.26508/lsa.201900516 · Cited by 22

Exploring Epigenetic and Genetic Modulation in Animal Responses to Thermal Stress

Wang, J., Raza, S. H. A., Pant, S. D., Juan, Z., Prakash, A., Abdelnour, S. A., Aloufi, B. H., Mahasneh, Z. M. H., Amin, A. A., Shokrollahi, B., et al. (2024) · Molecular Biotechnology · doi:10.1007/s12033-024-01126-5 · Cited by 23

Methods for Cancer Epigenome Analysis

Nagarajan, R. P., Fouse, S. D., Bell, R. J. A., & Costello, J. (2012) · Advances in experimental medicine and biology · doi:10.1007/978-1-4419-9967-2_15 · Cited by 22

Promises and challenges of anticancer drugs that target the epigenome

Verbrugge, I., Johnstone, R. W., & Bots, M. L. (2011) · Epigenomics · doi:10.2217/epi.11.82 · Cited by 22

Thioether Macrocyclic Peptides Selected against TET1 Compact Catalytic Domain Inhibit TET1 Catalytic Activity

Nishio, K., Belle, R., Katoh, T., Kawamura, A., Sengoku, T., Hanada, K., Ohsawa, N., Shirouzu, M., Yokoyama, S., & Suga, H. (2018) · ChemBioChem · doi:10.1002/cbic.201800047 · Cited by 22

Sulforaphane‐induced metabolomic responses with epigenetic changes in estrogen receptor positive breast cancer cells

Cao, S., Wang, L., Zhang, Z., Chen, F., Wu, Q., & Li, L. (2018) · FEBS Open Bio · doi:10.1002/2211-5463.12543 · Cited by 22

Altering TET dioxygenase levels within physiological range affects DNA methylation dynamics of HEK293 cells

Großer, C., Wagner, N., Grothaus, K., & Horsthemke, B. (2015) · Epigenetics · doi:10.1080/15592294.2015.1073879 · Cited by 22

'Memory and molecular turnover,’ 30 years after inception

Meagher, R. B. (2014) · Epigenetics & Chromatin · doi:10.1186/1756-8935-7-37 · Cited by 21

Gestational Diabetes Epigenetically Reprograms the Cart Promoter in Fetal Ovary, Causing Subfertility in Adult Life

Sinha, N., Biswas, A., Nave, O., Seger, C., & Sen, A. (2019) · Endocrinology · doi:10.1210/en.2019-00319 · Cited by 21

Investigating 5-Hydroxymethylcytosine (5hmC): The State of the Art

Nestor, C. E., Reddington, J. P., Benson, M., & Meehan, R. R. (2013) · Methods in molecular biology · doi:10.1007/978-1-62703-706-8_19 · Cited by 20

Ten-eleven translocation methyl-cytosine dioxygenase 2 deficiency exacerbates renal ischemia-reperfusion injury

Yan, H., Tan, L., Liu, Y., Huang, N., Cang, J., & Wang, H. (2020) · Clinical Epigenetics · doi:10.1186/s13148-020-00892-8 · Cited by 20

Epigenetic Changes and Chromatin Reorganization in Brain Function: Lessons from Fear Memory Ensemble and Alzheimer’s Disease

van Zundert, B., & Montecino, M. A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232012081 · Cited by 21

Multiple Functions of Ten-eleven Translocation 1 during Tumorigenesis

Tian, Y., Zhu, Y., Sun, X., & Lai, M. (2016) · Chinese Medical Journal · doi:10.4103/0366-6999.185873 · Cited by 20

The role of TET-mediated DNA hydroxymethylation in prostate cancer

Smeets, E., Lynch, A. G., Preković, S., den Broeck, T. V., Moris, L., Helsen, C., Joniau, S., Claessens, F., & Massie, C. E. (2017) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2017.08.021 · Cited by 20

A mutation in the tuft mouse disrupts TET1 activity and alters the expression of genes that are crucial for neural tube closure

Fong, K. S. K., Hufnagel, R. B., Khadka, V. S., Corley, M. J., Maunakea, A. K., Fogelgren, B., Ahmed, Z. M., & Lozanoff, S. (2016) · Disease Models & Mechanisms · doi:10.1242/dmm.024109 · Cited by 20

Functional Annotation of Proteins Encoded by the Minimal Bacterial Genome Based on Secondary Structure Element Alignment

Yang, Z., & Tsui, S. K.-W. (2018) · Journal of Proteome Research · doi:10.1021/acs.jproteome.8b00262 · Cited by 19

Structural Basis for the Recognition of Non-methylated DNA by the CXXC Domain

Liu, K., & Min, J. (2019) · Journal of Molecular Biology · doi:10.1016/j.jmb.2019.09.025 · Cited by 20

Understanding the Molecular Circuitry of Cell Lineage Specification in the Early Mouse Embryo

Bergsmedh, A., Donohoe, M. E., Hughes, R., & Hadjantonakis, A. (2011) · Genes · doi:10.3390/genes2030420 · Cited by 18

Epigenetic mechanisms involved in the effects of stress exposure: focus on 5-hydroxymethylcytosine: Table 1:

Hack, L. M., Dick, A. L. W., & Provençal, N. (2016) · Environmental Epigenetics · doi:10.1093/eep/dvw016 · Cited by 18

Metformin: A Promising Antidiabetic Medication for Cancer Treatment

Mu, W., Jiang, Y., Liang, G., Feng, Y., & Qu, F. (2022) · Current Drug Targets · doi:10.2174/1389450124666221104094918 · Cited by 18

Increasing Specificity of Targeted DNA Methylation Editing by Non-Enzymatic CRISPR/dCas9-Based Steric Hindrance

Sapozhnikov, D. M., & Szyf, M. (2023) · Biomedicines · doi:10.3390/biomedicines11051238 · Cited by 18

Epigenetic reprogramming: preparing the epigenome for the next generation

Rose, C. M., van den Driesche, S., Meehan, R. R., & Drake, A. J. (2013) · Biochemical Society Transactions · doi:10.1042/bst20120356 · Cited by 18

Epigenetics Primer: Why the Clinician Should Care About Epigenetics

Duarte, J. D. (2013) · Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy · doi:10.1002/phar.1325 · Cited by 18

Coregulator Sin3a Promotes Postnatal Murine β-Cell Fitness by Regulating Genes in Ca2+ Homeostasis, Cell Survival, Vesicle Biosynthesis, Glucose Metabolism, and Stress Response

Yang, X., Graff, S. M., Heiser, C. N., Ho, K., Chen, B., Simmons, A. J., Southard-Smith, A. N., David, G., Jacobson, D. A., Kaverina, I., et al. (2020) · Diabetes · doi:10.2337/db19-0721 · Cited by 16

EIF2S3Y suppresses the pluripotency state and promotes the proliferation of mouse embryonic stem cells

Li, N., Mu, H., Zheng, L., Li, B., Wu, C., Niu, B., Shen, Q., He, X., & Hua, J. (2016) · Oncotarget · doi:10.18632/oncotarget.7187 · Cited by 18

A Lexicon of DNA Modifications: Their Roles in Embryo Development and the Germline

Zhu, Q., Stöger, R. J., & Alberio, R. (2018) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2018.00024 · Cited by 21

New directions in treating peripheral T-cell lymphomas (PTCL): leveraging epigenetic modifiers alone and in combination

Ma, H., O’Connor, O. A., & Marchi, E. (2019) · Expert Review of Hematology · doi:10.1080/17474086.2019.1583102 · Cited by 18

Bend family proteins mark chromatin boundaries and synergistically promote early germ cell differentiation

Shi, G. W., Bai, Y., Zhang, X., Su, J., Pang, J., He, Q., Zeng, P., Ding, J., Xiong, Y., Zhang, J., et al. (2021) · Protein & Cell · doi:10.1007/s13238-021-00884-1 · Cited by 15

Phosphorylation stabilized TET1 acts as an oncoprotein and therapeutic target in B cell acute lymphoblastic leukemia

Chen, Z., Zhou, K., Xue, J., Small, A., Xiao, G., Nguyen, L. X. T., Zhang, Z., Prince, E. A., Weng, H., Huang, H., et al. (2023) · Science Translational Medicine · doi:10.1126/scitranslmed.abq8513 · Cited by 17

JBP1-seq: A fast and efficient method for genome-wide profiling of 5hmC

Cui, L., Chung, T. H., Tan, D., Sun, X., & Jia, X.-Y. (2014) · Genomics · doi:10.1016/j.ygeno.2014.08.023 · Cited by 17

Deciphering the multifaceted roles of TET proteins in T‐cell lineage specification and malignant transformation

Tsagaratou, A. (2021) · Immunological Reviews · doi:10.1111/imr.12940 · Cited by 16

Intra-Gene DNA Methylation Variability Is a Clinically Independent Prognostic Marker in Women’s Cancers

Bartlett, T. E., Jones, A., Goode, E. L., Fridley, B. L., Cunningham, J. M., Berns, E. M. J. J., Wik, E., Salvesen, H. B., Davidson, B., Trope, C. G., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0143178 · Cited by 16

5-Hydroxymethylcytosine and 5-formylcytosine containing deoxyoligonucleotides: Facile syntheses and melting temperature studies

Xuan, S., Wu, Q., Liang, C., Zhang, D., & Shao, F. (2015) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2015.01.070 · Cited by 17

Shoring up DNA methylation and H3K27me3 domain demarcation at developmental genes

Meehan, R. R., & Pennings, S. (2017) · The EMBO Journal · doi:10.15252/embj.201798498 · Cited by 16

Epigenetic Regulation of Cardiomyocyte Differentiation from Embryonic and Induced Pluripotent Stem Cells

Kim, Y. J., Tamadon, A., Kim, Y. Y., Kang, B.-C., & Ku, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22168599 · Cited by 19

Tet2 regulates Sin3a recruitment at active enhancers in embryonic stem cells

Flores, J. C., Sidoli, S., & Dawlaty, M. M. (2023) · iScience · doi:10.1016/j.isci.2023.107170 · Cited by 16

Analysis of Epigenetic Modifications of DNA in Human Cells

Kristensen, L. S., Treppendahl, M. B., & Grønbæk, K. (2013) · Current Protocols in Human Genetics · doi:10.1002/0471142905.hg2002s77 · Cited by 16

Prolonged Treatment with DNMT Inhibitors Induces Distinct Effects in Promoters and Gene-Bodies

Wong, Y. F., Jakt, L. M., & Nishikawa, S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0071099 · Cited by 16

Interrogating genomic and epigenomic data to understand prostate cancer

Kim, J., & Yu, J. (2012) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2011.12.003 · Cited by 16

Crosstalk Between DNA and Histones: Tet’s New Role in Embryonic Stem Cells

Sui, X., Price, C. O., Li, Z., & Chen, J. (2012) · Current Genomics · doi:10.2174/138920212803759730 · Cited by 17

Nucleosome dynamics and maintenance of epigenetic states of CpG islands

Dodd, I. B., & Sneppen, K. (2016) · Physical review. E · doi:10.1103/physreve.93.062417 · Cited by 16

Sequence features of retrotransposons allow for epigenetic variability

Costello, K. R., Leung, A., Trac, C., Lee, M., Basam, M., Pospisilik, J. A., & Schones, D. E. (2021) · eLife · doi:10.7554/elife.71104 · Cited by 16

Dysregulated TET Family Genes and Aberrant 5mC Oxidation in Breast Cancer: Causes and Consequences

Xu, B., Wang, H., & Tan, L. (2021) · Cancers · doi:10.3390/cancers13236039 · Cited by 16

Current and Emerging Technologies for the Analysis of the Genome-Wide and Locus-Specific DNA Methylation Patterns

Tost, J. (2022) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-11454-0_16 · Cited by 15

Mechanisms of human germ cell development

Saitou, M., Nagano, M., & Mizuta, K. (2025) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-025-00893-6 · Cited by 15

Peripheral T-cell lymphoma: From biology to practice to the future

O’Connor, O. A., Ma, H., Chan, J. Y., Kim, S. J., Yoon, S. E., & Kim, W. S. (2024) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2024.102793 · Cited by 15

Effects of TET1 knockdown on gene expression and DNA methylation in porcine induced pluripotent stem cells

Fan, A., Ma, K., An, X., Ding, Y., An, P., Song, G., Tang, L., Zhang, S., Zhang, P., Tan, W., et al. (2013) · Reproduction · doi:10.1530/rep-13-0212 · Cited by 15

Histone Demethylase Kdm2a Regulates Germ Cell Genes and Endogenous Retroviruses in Embryonic Stem Cells

Fu, E., Shen, J., Dong, Z., Zhang, W., Zhang, Y., Chen, F., Cheng, Z., Zhao, X. J., Shuai, L., & Lu, X. (2019) · Epigenomics · doi:10.2217/epi-2018-0126 · Cited by 15

TET3 controls the expression of the H3K27me3 demethylase Kdm6b during neural commitment

Montibus, B., Cercy, J., Bouschet, T., Charras, A., Maupetit‐Mehouas, S., Nury, D., Gonthier‐Guéret, C., Chauveau, S., Allègre, N., Chariau, C., et al. (2020) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03541-8 · Cited by 15

Tet1 Suppresses p21 to Ensure Proper Cell Cycle Progression in Embryonic Stem Cells

Chrysanthou, S., Flores, J. C., & Dawlaty, M. M. (2022) · Cells · doi:10.3390/cells11081366 · Cited by 15

High-throughput single nucleotide variant discovery in E14 mouse embryonic stem cells provides a new reference genome assembly

Incarnato, D., Křepelová, A., & Neri, F. (2014) · Genomics · doi:10.1016/j.ygeno.2014.06.007 · Cited by 15

The dynamic changes of DNA methylation in primordial germ cell differentiation

Duan, L., Liu, Y., Wang, J., Liao, J., & Hu, J. (2016) · Gene · doi:10.1016/j.gene.2016.06.036 · Cited by 14

Competitive binding of TET1 and DNMT3A/B cooperates the DNA methylation pattern in human embryonic stem cells

Chao, L., Yang, S., Li, H., Long, C., Xi, Q., & Zuo, Y. (2022) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2022.194861 · Cited by 14

Adora2A downregulation promotes caffeine neuroprotective effect against LPS-induced neuroinflammation in the hippocampus

Sanna, P. L. D. S., Carvalho, L. B., Afonso, C. C. D. S., de Carvalho, K., Aires, R., Souza, J., Ferreira, M. R., Birbrair, A., Bernardi, M. M., Latini, A., et al. (2024) · Brain Research · doi:10.1016/j.brainres.2024.148866 · Cited by 14

CTCF demarcates chicken embryonic α-globingene autonomous silencing and contributes to adult stage-specific gene expression

Valdes‐Quezada, C., Arriaga-Canon, C., Fonseca-Guzmán, Y., Guerrero, G., & Targa, F. R. (2013) · Epigenetics · doi:10.4161/epi.25472 · Cited by 14

The Tet1 and histone methylation expression pattern in dairy goat testis

Zheng, L., Zhu, H., Tang, F., Mu, H., Li, N., Wu, J., & Hua, J. (2015) · Theriogenology · doi:10.1016/j.theriogenology.2014.12.020 · Cited by 14

Dynamic heterogeneity of DNA methylation and hydroxymethylation in embryonic stem cell populations captured by single-cell 3D high-content analysis

Tajbakhsh, J., Stefanovski, D., Tang, G., Wawrowsky, K., Liu, N., & Fair, J. H. (2015) · Experimental Cell Research · doi:10.1016/j.yexcr.2015.02.004 · Cited by 14

DNA hydroxymethylation is associated with disease severity and persists at enhancers of oncogenic regions in multiple myeloma

Alberge, J.-B., Magrangeas, F., Wagner, M., Denié, S., Guérin‐Charbonnel, C., Campion, L., Attal, M., Avet‐Loiseau, H., Carell, T., Moreau, P., et al. (2020) · Clinical Epigenetics · doi:10.1186/s13148-020-00953-y · Cited by 14

Soft repression: Subtle transcriptional regulation with global impact

Mitra, A., Raicu, A., Hickey, S. L., Pile, L. A., & Arnosti, D. N. (2020) · BioEssays · doi:10.1002/bies.202000231 · Cited by 14

Role of DNA De-methylation intermediate ‘5-hydroxymethylcytosine’ in ovarian cancer management: A comprehensive review

Bisht, D., Arora, A., & Sachan, M. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113674 · Cited by 16

Dual functions of TET1 in germ layer lineage bifurcation distinguished by genomic context and dependence on 5-methylcytosine oxidation

van der Veer, B. K., Chen, L., Custers, C., Athanasouli, P., Schroiff, M., Cornelis, R., Chui, J. S., Finnell, R. H., Lluís, F., & Koh, K. P. (2023) · Nucleic Acids Research · doi:10.1093/nar/gkad231 · Cited by 17

Epigenetic modification in gliomas: role of the histone methyltransferase EZH2

Bian, E.-B., Li, J., He, X.-J., Zong, G., Jiang, T., Li, J., & Zhao, B. (2014) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2014.941807 · Cited by 12

A Bisulfite-free Approach for Base-Resolution Analysis of Genomic 5-Carboxylcytosine

Ličytė, J., Gibas, P., Skardžiūtė, K., Stankevičius, V., Rukšėnaitė, A., & Kriukienė, E. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.108155 · Cited by 15

Conflicts of CpG density and DNA methylation are proximally and distally involved in gene regulation in human and mouse tissues

Chen, F., Zhang, Q., Deng, X., Zhang, X., Chen, C., Lv, D., Li, Y., Li, D., Zhang, Y., Li, P., et al. (2018) · Epigenetics · doi:10.1080/15592294.2018.1500057 · Cited by 13

Crosstalk within and beyond the Polycomb repressive system

Shi, T., Sugishita, H., & Gotoh, Y. (2024) · The Journal of Cell Biology · doi:10.1083/jcb.202311021 · Cited by 12

Role for Tet in Hyperglycemia-Induced Demethylation: A Novel Mechanism of Diabetic Metabolic Memory

Ding, G., & Huang, H. (2014) · Diabetes · doi:10.2337/db14-0675 · Cited by 13

Oxidation Products of 5-Methylcytosine are Decreased in Senescent Cells and Tissues of Progeroid Mice

Zarakowska, E., Czerwińska, J., Tupalska, A., Yousefzadeh, M., Gregg, S. Q., Croix, C. M. S., Niedernhofer, L. J., Foksiński, M., Gackowski, D., Szpila, A., et al. (2018) · The Journals of Gerontology Series A · doi:10.1093/gerona/gly012 · Cited by 12

Deletion of Tet proteins results in quantitative disparities during ESC differentiation partially attributable to alterations in gene expression

Reimer, M. H., Pulakanti, K., Shi, L., Abel, A. M., Liang, M., Malarkannan, S., & Rao, S. (2019) · BMC Developmental Biology · doi:10.1186/s12861-019-0196-6 · Cited by 13

Alterations in 5hmC Level and Genomic Distribution in Aging-Related Epigenetic Drift in Human Adipose Stem Cells

Borkowska, J., Domaszewska-Szostek, A., Kołodziej, P., Wicik, Z., Połosak, J., Buyanovskaya, O. A., Charzewski, Ł., Stańczyk, M., Noszczyk, B. H., & Puzianowska‐Kuźnicka, M. (2020) · Epigenomics · doi:10.2217/epi-2019-0131 · Cited by 14

Immunoprecipitation and mass spectrometry define TET1 interactome during oligodendrocyte differentiation

Zhang, M., Zhang, K., Wang, J., Liu, Y., Liu, G., Jin, W., Wu, S., & Zhao, X. (2020) · Cell & Bioscience · doi:10.1186/s13578-020-00473-5 · Cited by 13

Reprogramming chromatin

Ehrensberger, A. H., & Svejstrup, J. Q. (2012) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409238.2012.697125 · Cited by 14

The Epigenetic Effect of Trematode Infection on the Snail Host Zeacumantus subcarinatus

Joe, M. (2013) · Otago University Research Archive (University of Otago) · Cited by 13

Coordination of germ layer lineage choice by TET1 during primed pluripotencyPreprint

Luo, X., van der Veer, B. K., Sun, L., Bartoccetti, M., Boretto, M., Vankelecom, H. E. J., Khoueiry, R., & Koh, K. P. (2020) · Genes & Development · doi:10.1101/gad.329474.119 · Cited by 13

Tracing TET1 expression in prostate cancer: discovery of malignant cells with a distinct oncogenic signature

Schagdarsurengin, U., Luo, C., Slanina, H., Sheridan, D., Fuessel, S., Böğürcü, N., Gattenloehner, S., Baretton, G., Hofbauer, L. C., Wagenlehner, F. R. A., et al. (2021) · Clinical Epigenetics · doi:10.1186/s13148-021-01201-7 · Cited by 12

Epigenetics of cell fate reprogramming and its implications for neurological disorders modelling

Grzybek, M., Golonko, A., Walczak, M., & Lisowski, P. (2016) · Neurobiology of Disease · doi:10.1016/j.nbd.2016.11.007 · Cited by 12

Electrogenerated chemiluminescence biosensing method for DNA hydroxymethylation detection via glycosylation and a new multi-functional ECL signal compound

Sun, H., Zhang, J., Bai, W., & Li, Y. (2020) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2020.128582 · Cited by 12

Outer membrane vesicles from bacteria: Role and potential value in the pathogenesis of chronic respiratory diseases

Han, F., Wang, W., Shi, M. Q., Zhou, H., Yao, Y., Li, C., & Shang, A. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.1093327 · Cited by 12

Loss of Fam60a, a Sin3a subunit, results in embryonic lethality and is associated with aberrant methylation at a subset of gene promoters

Nabeshima, R., Nishimura, O., Maeda, T., Shimizu, N., Ide, T., Yashiro, K., Sakai, Y., Meno, C., Kadota, M., Shiratori, H., et al. (2018) · eLife · doi:10.7554/elife.36435 · Cited by 12

Transcriptomic analysis of pluripotent stem cells: insights into health and disease

Yeo, J.-C., & Ng, H. (2011) · Genome Medicine · doi:10.1186/gm284 · Cited by 12

Modification of Tet1 and histone methylation dynamics in dairy goat male germline stem cells

Zheng, L., Zhai, Y., Li, N., Wu, C., Zhu, H., Wei, Z., Bai, C., Li, G., & Hua, J. (2016) · Cell Proliferation · doi:10.1111/cpr.12245 · Cited by 12

Unraveling the epigenetic landscape of glomerular cells in kidney disease

Pereira, B. M. V., Katakia, Y. T., Majumder, S., & Thieme, K. (2021) · Journal of Molecular Medicine · doi:10.1007/s00109-021-02066-2 · Cited by 11

The emerging role of TET enzymes in the immune microenvironment at the maternal-fetal interface during decidualization and early pregnancy

Jin, M., Ji, J., Chen, X., Zhou, Y. Y., Wang, D., & Liu, A.-X. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1066599 · Cited by 11

Tet methylcytosine dioxygenase 1 modulates Porphyromonas gingivalis–triggered pyroptosis by regulating glycolysis in cementoblasts

Peng, Y., Wang, H., Huang, X., Liu, H., Xiao, J., Wang, C., Ma, L., Wang, X., & Cao, Z. (2023) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.14979 · Cited by 11

Active DNA Demethylase, TET1, Increases Oxidative Phosphorylation and Sensitizes Ovarian Cancer Stem Cells to Mitochondrial Complex I Inhibitor

Chen, L., Shen, Y., Chu, L.-H., Su, P., Wang, H.-C., Weng, Y., Lin, S., Wen, K., Liew, P., & Lai, H. (2024) · Antioxidants · doi:10.3390/antiox13060735 · Cited by 11

Embracing change to remain the same: conservation of polycomb functions despite divergence of binding motifs among species

Sharif, J., Endo, T. A., Ito, S., Ohara, O., & Koseki, H. (2013) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2013.02.009 · Cited by 12

Integrative analysis of DNA methylation and mRNA expression during differentiation of umbilical cord blood derived mononuclear cells to endothelial cells

Jeong, Y., Jun, Y., Kim, J., Park, H., Choi, K.-S., Zhang, H., Park, J. A., Kwon, J., Kim, Y., Lee, S., et al. (2017) · Gene · doi:10.1016/j.gene.2017.09.006 · Cited by 11

Dual functions of Tet1 in transcriptional regulation in mouse embryonic stem cells

Wu, H., D’Alessio, A. C., Ito, S., Xia, K., Wang, Z., Cui, K., Zhao, K., Eve Sun, Y., & Zhang, Y. (2011) · Nature · doi:10.1038/nature09934 · Cited by 646

Tet proteins in the limelight

Véron, N., & Peters, A. H. F. M. (2011) · Nature · doi:10.1038/473293a · Cited by 34

Genome-wide Regulation of 5hmC, 5mC, and Gene Expression by Tet1 Hydroxylase in Mouse Embryonic Stem Cells

Xu, Y., Wu, F., Tan, L., Kong, L., Xiong, L., Deng, J., Barbera, A. J., Zheng, L., Zhang, H., Huang, S., et al. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.04.005 · Cited by 647

Dynamic regulation of 5-hydroxymethylcytosine in mouse ES cells and during differentiation

Ficz, G., Branco, M. R., Seisenberger, S., Santos, F., Krueger, F., Hore, T. A., Marques, C. J., Andrews, S., & Reik, W. (2011) · Nature · doi:10.1038/nature10008 · Cited by 1,160

Cytosine hydroxymethylation by TET enzymes: From the control of gene expression to the regulation of DNA repair mechanisms, and back

Lejart, A., Univ Rennes, C., Salbert, G., & Huet, S. (2018) · AIMS Biophysics · doi:10.3934/biophy.2018.3.182 · Cited by 3