TET1 and hydroxymethylcytosine in transcription and DNA methylation fidelity

Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1

Tahiliani, M., Koh, K. P., Shen, Y., Pastor, W. A., Bandukwala, H., Brudno, Y., Agarwal, S., Iyer, L. M., Liu, D. R., Aravind, L., et al. (2009) · Science · doi:10.1126/science.1170116 · Cited by 5,836

Genome-wide maps of chromatin state in pluripotent and lineage-committed cells

Mikkelsen, T. S., Ku, M., Jaffe, D. B., Issac, B., Lieberman, E., Giannoukos, G., Alvarez, P., Brockman, W., Kim, T.-K., Koche, R. P., et al. (2007) · Nature · doi:10.1038/nature06008 · Cited by 4,129

DNA methylation landscapes: Provocative insights from epigenomics

Suzuki, M. M., & Bird, A. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2341 · Cited by 3,039

The Nuclear DNA Base 5-Hydroxymethylcytosine Is Present in Purkinje Neurons and the Brain

Kriaucionis, S., & Heintz, N. (2009) · Science · doi:10.1126/science.1169786 · Cited by 2,700

Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification

Ito, S., D’Alessio, A. C., Taranova, O., Hong, K., Sowers, L. C., & Zhang, Y. (2010) · Nature · doi:10.1038/nature09303 · Cited by 2,628

Genome-scale DNA methylation maps of pluripotent and differentiated cells

Meissner, A., Mikkelsen, T. S., Gu, H., Wernig, M., Hanna, J., Sivachenko, A., Zhang, X., Bernstein, B. E., Nusbaum, C., Jaffe, D. B., et al. (2008) · Nature · doi:10.1038/nature07107 · Cited by 2,536

Linking DNA methylation and histone modification: patterns and paradigms

Cedar, H., & Bergman, Y. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2540 · Cited by 2,267

Chromosome-wide and promoter-specific analyses identify sites of differential DNA methylation in normal and transformed human cells

Weber, M., Davies, J. J., Wittig, D., Oakeley, E. J., Haase, M., Lam, W. L., & Schübeler, D. (2005) · Nature Genetics · doi:10.1038/ng1598 · Cited by 1,785

Mutation in TET2 in Myeloid Cancers

Delhommeau, F., Dupont, S., Valle, V. D., James, C., Trannoy, S., Massé, A., Kosmider, O., Le Couedic, J.-P., Robert, F., Alberdi, A., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0810069 · Cited by 1,776

Conserved role of intragenic DNA methylation in regulating alternative promoters

Maunakea, A. K., Nagarajan, R. P., Bilenky, M., Ballinger, T. J., D’Souza, C., Fouse, S. D., Johnson, B. E., Hong, C., Nielsen, C., Zhao, Y., et al. (2010) · Nature · doi:10.1038/nature09165 · Cited by 1,743

Isocitrate dehydrogenases in physiology and cancer: biochemical and molecular insight

Al‐Khallaf, H. (2017) · Cell & Bioscience · doi:10.1186/s13578-017-0165-3 · Cited by 133

Tet1 and Tet2 maintain mesenchymal stem cell homeostasis via demethylation of the P2rX7 promoter

Yang, R., Yu, T., Kou, X., Gao, X., Chen, C., Liu, D., Zhou, Y., & Shi, S. (2018) · Nature Communications · doi:10.1038/s41467-018-04464-6 · Cited by 125

Effects ofTET2mutations on DNA methylation in chronic myelomonocytic leukemia

Yamazaki, J., Taby, R. F., Vasanthakumar, A., Macrae, T. A., Ostler, K. R., Shen, L., Kantarjian, H. M., Estecio, M. R., Jelı́nek, J., Godley, L. A., et al. (2012) · Epigenetics · doi:10.4161/epi.7.2.19015 · Cited by 125

Upregulation of TET1 and downregulation of APOBEC3A and APOBEC3C in the parietal cortex of psychotic patients

Dong, E., Gavin, D. P., Chen, Y., & Davis, J. M. (2012) · Translational Psychiatry · doi:10.1038/tp.2012.86 · Cited by 121

Regulation of DNA methylation turnover at LTR retrotransposons and imprinted loci by the histone methyltransferase Setdb1

Leung, D., Du, T., Wagner, U., Xie, W., Lee, A. Y., Goyal, P., Li, Y., Szulwach, K. E., Jin, P., Lorincz, M. C., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1322273111 · Cited by 125

Isoform‐specific localization of DNMT3A regulates DNA methylation fidelity at bivalent CpG islands

Manzo, M., Wirz, J., Ambrosi, C. M., Villaseñor, R., Roschitzki, B., & Baubec, T. (2017) · The EMBO Journal · doi:10.15252/embj.201797038 · Cited by 128

An Epigenetic Role of Mitochondria in Cancer

Liu, Y., Chen, C., Wang, X., Sun, Y., Zhang, J., Chen, J., & Shi, Y. (2022) · Cells · doi:10.3390/cells11162518 · Cited by 131

Reprogramming the epigenome with vitamin C

Lee Chong, T., Ahearn, E. L., & Cimmino, L. (2019) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2019.00128 · Cited by 120

Alteration of genic 5-hydroxymethylcytosine patterning in olfactory neurons correlates with changes in gene expression and cell identity

Colquitt, B. M., Allen, W. E., Barnea, G., & Lomvardas, S. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1302759110 · Cited by 118

Dynamic DNA methylation of matrix metalloproteinase-9 in the development of diabetic retinopathy

Kowluru, R. A., Shan, Y., & Mishra, M. (2016) · Laboratory Investigation · doi:10.1038/labinvest.2016.78 · Cited by 120

Crosstalk between metabolism and epigenetics during macrophage polarization

Zhang, K., & Jagannath, C. (2025) · Epigenetics & Chromatin · doi:10.1186/s13072-025-00575-9 · Cited by 137

TET Enzymes in the Immune System: From DNA Demethylation to Immunotherapy, Inflammation, and Cancer

López-Moyado, I. F., Ko, M., Hogan, P. G., & Rao, A. (2024) · Annual Review of Immunology · doi:10.1146/annurev-immunol-080223-044610 · Cited by 121

Playing TETris with DNA modifications

Delatte, B., Deplus, R., & Fuks, F. (2014) · The EMBO Journal · doi:10.15252/embj.201488290 · Cited by 118

Nuclear Exclusion of TET1 Is Associated with Loss of 5-Hydroxymethylcytosine in IDH1 Wild-Type Gliomas

Müller, T., Gessi, M., Waha, A., Isselstein, L., Luxen, D., Freihoff, D., Freihoff, J., Becker, A. J., Simon, M., Hammes, J., et al. (2012) · American Journal Of Pathology · doi:10.1016/j.ajpath.2012.04.017 · Cited by 116

The role of 5-hydroxymethylcytosine in human cancer

Pfeifer, G. P., Xiong, W., Hahn, M. A., & Jin, S. (2014) · Cell and Tissue Research · doi:10.1007/s00441-014-1896-7 · Cited by 118

The Dynamics and Prognostic Potential of DNA Methylation Changes at Stem Cell Gene Loci in Women's Cancer

Zhuang, J. J., Jones, A., Lee, S., Ng, E., Fiegl, H., Zikán, M., Cibula, D., Sargent, A., Salvesen, H. B., Jacobs, I. J., et al. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002517 · Cited by 117

Function determinants of TET proteins: the arrangements of sequence motifs with specific codes

Liu, D., Li, G., & Zuo, Y. (2018) · Briefings in Bioinformatics · doi:10.1093/bib/bby053 · Cited by 115

Orphan CpG islands amplify poised enhancer regulatory activity and determine target gene responsiveness

Pachano, T., Sánchez-Gaya, V., Ealo, T., Mariner-Faulí, M., Bleckwehl, T., Asenjo, H. G., Respuela, P., Cruz-Molina, S., Muñoz-San Martín, M., Haro, E., et al. (2021) · Nature Genetics · doi:10.1038/s41588-021-00888-x · Cited by 116

5-Hydroxymethylcytosine localizes to enhancer elements and is associated with survival in glioblastoma patients

Johnson, K. C., Houseman, E. A., King, J. E., von Herrmann, K. M., Fadul, C. E., & Christensen, B. C. (2016) · Nature Communications · doi:10.1038/ncomms13177 · Cited by 123

Epigenetics

Tollervey, J. R., & Lunyak, V. V. (2012) · Epigenetics · doi:10.4161/epi.21141 · Cited by 124

Distinct and overlapping control of 5-methylcytosine and 5-hydroxymethylcytosine by the TET proteins in human cancer cells

Putiri, E. L., Tiedemann, R. L., Thompson, J. J., Liu, C., Ho, T. H., Choi, J.-H., & Robertson, K. D. (2014) · Genome biology · doi:10.1186/gb-2014-15-6-r81 · Cited by 111

OGG1 is essential in oxidative stress induced DNA demethylation

Zhou, X.-L., Zhuang, Z., Wang, W., He, L., Wu, H., Cao, Y., Pan, F., Zhao, J., Hu, Z., Sekhar, C., et al. (2016) · Cellular Signalling · doi:10.1016/j.cellsig.2016.05.021 · Cited by 121

Lineage-specific functions of TET1 in the postimplantation mouse embryo

Khoueiry, R., Sohni, A., Thienpont, B., Luo, X., Velde, J. V., Bartoccetti, M., Boeckx, B., Zwijsen, A., Rao, A., Lambrechts, D., et al. (2017) · Nature Genetics · doi:10.1038/ng.3868 · Cited by 112

Genome-wide comparison of DNA hydroxymethylation in mouse embryonic stem cells and neural progenitor cells by a new comparative hMeDIP-seq method

Tan, L., Xiong, L., Xu, W., Wu, F., Huang, N., Xu, Y., Kong, L., Zheng, L., Schwartz, L., Shi, Y., et al. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt091 · Cited by 115

Isoform Switch of TET1 Regulates DNA Demethylation and Mouse Development

Zhang, W., Xia, W., Wang, Q., Towers, A. J., Chen, J., Gao, R., Zhang, Y., Yen, C., Lee, A. Y., Li, Y., et al. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.10.030 · Cited by 114

Fetal DNA Methylation Associates with Early Spontaneous Preterm Birth and Gestational Age

Parets, S. E., Conneely, K. N., Kilaru, V., Fortunato, S. J., Syed, T. A., Saade, G. R., Smith, A. K., & Menon, R. (2013) · PLoS ONE · doi:10.1371/journal.pone.0067489 · Cited by 109

Non-catalytic Roles of Tet2 Are Essential to Regulate Hematopoietic Stem and Progenitor Cell Homeostasis

Ito, K., Lee, J., Chrysanthou, S., Zhao, Y., Josephs, K. S., Sato, H., Teruya‐Feldstein, J., Zheng, D., Dawlaty, M. M., & Ito, K. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.07.094 · Cited by 113

Structural Basis for Hydroxymethylcytosine Recognition by the SRA Domain of UHRF2

Zhou, T., Xiong, J., Wang, M., Yang, N., Wong, J., Zhu, B., & Xu, R.-M. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.04.003 · Cited by 106

Epigenetic Modifications and Diabetic Retinopathy

Kowluru, R. A., dos Santos, J. M., & Mishra, M. (2013) · BioMed Research International · doi:10.1155/2013/635284 · Cited by 110

Next generation sequencing in epigenetics: Insights and challenges

Meaburn, E. L., & Schulz, R. (2011) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2011.10.010 · Cited by 110

Lin28A Binds Active Promoters and Recruits Tet1 to Regulate Gene Expression

Zeng, Y., Yao, B., Shin, J., Lin, L., Kim, N., Song, Q., Liu, S., Su, Y., Guo, J. U., Huang, L., et al. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.11.020 · Cited by 102

Tissue-specific DNA demethylation is required for proper B-cell differentiation and function

Orlanski, S., Labi, V., Reizel, Y., Spiro, A., Lichtenstein, M., Levin-Klein, R., Koralov, S. B., Skversky‐Blocq, Y., Rajewsky, K., Cedar, H., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1604365113 · Cited by 103

The role of α-ketoglutarate–dependent proteins in pluripotency acquisition and maintenance

Tran, K. A., Dillingham, C. M., & Sridharan, R. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.tm118.000831 · Cited by 110

Clinical, molecular, and prognostic correlates of number, type, and functional localization of TET2 mutations in chronic myelomonocytic leukemia (CMML)—a study of 1084 patients

Coltro, G., Mangaonkar, A. A., Lasho, T. L., Finke, C. M., Pophali, P. A., Carr, R. M., Gangat, N., Binder, M., Pardanani, A. D., Fernández-Zapico, M. E., et al. (2019) · Leukemia · doi:10.1038/s41375-019-0690-7 · Cited by 107

Epigenetic Regulation of Genomic Stability by Vitamin C

Brabson, J. P., Leesang, T. E., Mohammad, S., & Cimmino, L. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.675780 · Cited by 111

The male germ cell gene regulator CTCFL is functionally different from CTCF and binds CTCF-like consensus sites in a nucleosome composition-dependent manner

Sleutels, F., Soochit, W., Bartkuhn, M., Heath, H., Dienstbach, S., Bergmaier, P., Franke, V., Rosa-Garrido, M., van de Nobelen, S., Caesar, L., et al. (2012) · Epigenetics & Chromatin · doi:10.1186/1756-8935-5-8 · Cited by 96

C/EBPα Is Required for Long-Term Self-Renewal and Lineage Priming of Hematopoietic Stem Cells and for the Maintenance of Epigenetic Configurations in Multipotent Progenitors

Hasemann, M. S., Lauridsen, F. K. B., Waage, J., Jakobsen, J. S., Frank, A.-K., Schuster, M. B., Rapin, N., Bagger, F. O., Hoppe, P. S., Schroeder, T., et al. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004079 · Cited by 115

A reassessment of DNA-immunoprecipitation-based genomic profiling

Lentini, A., Lagerwall, C., Vikingsson, S., Mjoseng, H. K., Douvlataniotis, K., Vogt, H., Gréen, H., Meehan, R. R., Benson, M., & Nestor, C. E. (2018) · Nature Methods · doi:10.1038/s41592-018-0038-7 · Cited by 105

Versatile Electrochemiluminescence and Electrochemical “On–Off” Assays of Methyltransferases and Aflatoxin B1 Based on a Novel Multifunctional DNA Nanotube

Ge, J., Zhao, Y., Li, C., & Jie, G. (2019) · Analytical Chemistry · doi:10.1021/acs.analchem.8b05362 · Cited by 103

TET-Mediated Hypermethylation Primes SDH-Deficient Cells for HIF2α-Driven Mesenchymal Transition

Morin, A., Goncalves, J., Moog, S., Castro‐Vega, L. J., Job, S., Buffet, A., Fontenille, M., Woszczyk, J., Gimenez‐Roqueplo, A., Letouzé, É., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.03.022 · Cited by 110

Combined Loss of Tet1 and Tet2 Promotes B Cell, but Not Myeloid Malignancies, in Mice

Zhao, Z., Chen, L., Dawlaty, M. M., Pan, F., Weeks, O. I., Zhou, Y., Cao, Z., Shi, H., Wang, J., Lin, L., et al. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.10.037 · Cited by 104

The concurrence of DNA methylation and demethylation is associated with transcription regulation

Shi, J., Xu, J., Chen, Y. E., Li, J. S., Cui, Y., Shen, L., Li, J. J., & Li, W. (2021) · Nature Communications · doi:10.1038/s41467-021-25521-7 · Cited by 102

Different Roles for Tet1 and Tet2 Proteins in Reprogramming-Mediated Erasure of Imprints Induced by EGC Fusion

Piccolo, F. M., Bagci, H., Brown, K. E., Landeira, D., Soza-Ried, J., Feytout, A., Mooijman, D., Hájková, P., Leitch, H. G., Tada, T., et al. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.01.032 · Cited by 99

The GLIB technique for genome-wide mapping of 5-hydroxymethylcytosine

Pastor, W. A., Huang, Y., Henderson, H. R., Agarwal, S., & Rao, A. (2012) · Nature Protocols · doi:10.1038/nprot.2012.104 · Cited by 98

Hydroxymethylation at Gene Regulatory Regions Directs Stem/Early Progenitor Cell Commitment during Erythropoiesis

Madžo, J., Liu, H., Rodriguez, A., Vasanthakumar, A., Sundaravel, S., Caces, D. B., Looney, T. J., Zhang, L., Lepore, J. B., Macrae, T. A., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2013.11.044 · Cited by 99

Dynamic changes in DNA methylation and hydroxymethylation when hES cells undergo differentiation toward a neuronal lineage

Kim, M., Park, Y.-K., Kang, T.-W., Lee, S.-H., Rhee, Y.-H., Park, J.-L., Kim, H.-J., Lee, D., Lee, D., Kim, S.-Y., et al. (2014) · Human Molecular Genetics · doi:10.1093/hmg/ddt453 · Cited by 98

Acute depletion of Tet1-dependent 5-hydroxymethylcytosine levels impairs LIF/Stat3 signaling and results in loss of embryonic stem cell identity

Freudenberg, J., Ghosh, S., Lackford, B. L., Yellaboina, S., Zheng, X., Li, R., Cuddapah, S., Wade, P. A., Hu, G., & Jothi, R. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr1253 · Cited by 98

TET2 Regulates Mast Cell Differentiation and Proliferation through Catalytic and Non-catalytic Activities

Montagner, S., Leoni, C., Emming, S., Chiara, G. D., Balestrieri, C., Barozzi, I., Piccolo, V., Togher, S., Ko, M., Rao, A., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.04.044 · Cited by 102

Glucocorticoid-induced loss of DNA methylation in non-neuronal cells and potential involvement of DNMT1 in epigenetic regulation of Fkbp5

Yang, X., Ewald, E. R., Huo, Y., Tamashiro, K. L., Salvatori, R., Sawa, A., Wand, G. S., & Lee, R. S. (2012) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2012.03.035 · Cited by 99

Subtelomeric hotspots of aberrant 5-hydroxymethylcytosine-mediated epigenetic modifications during reprogramming to pluripotency

Wang, T., Wu, H., Li, Y., Szulwach, K. E., Lin, L., Li, X., Chen, I., Goldlust, I. S., Chamberlain, S. J., Dodd, A., et al. (2013) · Nature Cell Biology · doi:10.1038/ncb2748 · Cited by 97

The anti-CMS technique for genome-wide mapping of 5-hydroxymethylcytosine

Huang, Y., Pastor, W. A., Zepeda-Martínez, J. A., & Rao, A. (2012) · Nature Protocols · doi:10.1038/nprot.2012.103 · Cited by 96

Cell Cycle-Dependent Turnover of 5-Hydroxymethyl Cytosine in Mouse Embryonic Stem Cells

Otani, J., Kimura, H., Sharif, J., Endo, T. A., Mishima, Y., Kawakami, T., Koseki, H., Shirakawa, M., Suetake, I., & Tajima, S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0082961 · Cited by 103

The role of 5-hydroxymethylcytosine in development, aging and age-related diseases

López, V., Fernández, A. F., & Fraga, M. F. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2017.05.002 · Cited by 101

Short-term memory of danger signals and environmental stimuli in immune cells

Monticelli, S., & Natoli, G. (2013) · Nature Immunology · doi:10.1038/ni.2636 · Cited by 92

TET2 binding to enhancers facilitates transcription factor recruitment in hematopoietic cells

Rasmussen, K. D., Berest, I., Keβler, S., Nishimura, K., Simón-Carrasco, L., Vassiliou, G. S., Pedersen, M. T., Christensen, J., Zaugg, J. B., & Helin, K. (2019) · Genome Research · doi:10.1101/gr.239277.118 · Cited by 95

Tet2 Facilitates the Derepression of Myeloid Target Genes during CEBPα-Induced Transdifferentiation of Pre-B Cells

Kallin, E. M., Rodríguez-Ubreva, J., Christensen, J., Cimmino, L., Aifantis, I., Helin, K., Ballestar, E., & Graf, T. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.08.007 · Cited by 92

Regulation of the Methylation and Expression Levels of the BMPR2 Gene by SIN3a as a Novel Therapeutic Mechanism in Pulmonary Arterial Hypertension

Bisserier, M., Mathiyalagan, P., Zhang, S., Elmastour, F., Dorfmüller, P., Humbert, M. J. C., David, G., Tarzami, S. T., Weber, T., Perros, F., et al. (2021) · Circulation · doi:10.1161/circulationaha.120.047978 · Cited by 96

Comprehensive evaluation of genome-wide 5-hydroxymethylcytosine profiling approaches in human DNA

Skvortsova, K., Zotenko, E., Luu, P., Gould, C. M., Nair, S. S., Clark, S. J., & Stirzaker, C. (2017) · Epigenetics & Chromatin · doi:10.1186/s13072-017-0123-7 · Cited by 98

Time-dependent effect of 1,6-hexanediol on biomolecular condensates and 3D chromatin organization

Liu, X., Jiang, S., Ma, L., Qu, J., Zhao, L., Zhu, X. Q., & Ding, J. (2021) · Genome biology · doi:10.1186/s13059-021-02455-3 · Cited by 100

Oxidized C5-methyl cytosine bases in DNA: 5-Hydroxymethylcytosine; 5-formylcytosine; and 5-carboxycytosine

Klungland, A., & Robertson, A. B. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.11.038 · Cited by 97

Unlocking epigenetic codes in neurogenesisPreprint

Yao, B., & Jin, P. (2014) · Genes & Development · doi:10.1101/gad.241547.114 · Cited by 97

Age-Related Increase in Levels of 5-Hydroxymethylcytosine in Mouse Hippocampus is Prevented by Caloric Restriction

Chouliaras, L., L.A. van den Hove, D., Kenis, G., Keitel, S., R. Hof, P., van Os, J., W.M. Steinbusch, H., Schmitz, C., & P.F. Rutten, B. (2012) · Current Alzheimer Research · doi:10.2174/156720512800618035 · Cited by 91

DNA methylation and methylcytosine oxidation in cell fate decisions

Koh, K. P., & Rao, A. (2013) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2013.02.014 · Cited by 96

The SIN3A/HDAC Corepressor Complex Functionally Cooperates with NANOG to Promote Pluripotency

Saunders, A., Huang, X., Fidalgo, M., Reimer, M. H., Faiola, F., Ding, J., Sánchez-Priego, C., Guallar, D., Sáenz, C., Li, D., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.01.055 · Cited by 92

Sequence determinants, function, and evolution of CpG islands

Angeloni, A., & Bogdanović, O. (2021) · Biochemical Society Transactions · doi:10.1042/bst20200695 · Cited by 101

DNA (de)methylation in embryonic stem cells controls CTCF-dependent chromatin boundariesPreprint

Wiehle, L., Thorn, G. J., Raddatz, G., Clarkson, C. T., Rippe, K., Lyko, F., Breiling, A., & Teif, V. B. (2019) · Genome Research · doi:10.1101/gr.239707.118 · Cited by 92

TET enzymes, DNA demethylation and pluripotency

Ross, S. E., & Bogdanović, O. (2019) · Biochemical Society Transactions · doi:10.1042/bst20180606 · Cited by 95

Developmental enhancers revealed by extensive DNA methylome maps of zebrafish early embryos

Lee, H. J., Lowdon, R. F., Maricque, B. B., Zhang, B., Stevens, M. W., Li, D., Johnson, S. L., & Wang, T. (2015) · Nature Communications · doi:10.1038/ncomms7315 · Cited by 92

Improved Synthesis and Mutagenicity of Oligonucleotides Containing 5‐Hydroxymethylcytosine, 5‐Formylcytosine and 5‐Carboxylcytosine

Münzel, M., Lischke, U., Stathis, D., Pfaffeneder, T., Gnerlich, F. A., Deiml, C. A., Koch, S. C., Karaghiosoff, K., & Carell, T. (2011) · Chemistry - A European Journal · doi:10.1002/chem.201102782 · Cited by 90

The Discovery of 5‐Formylcytosine in Embryonic Stem Cell DNA

Pfaffeneder, T., Hackner, B., Truß, M., Münzel, M., Müller, M., Deiml, C. A., Hagemeier, C., & Carell, T. (2011) · Angewandte Chemie · doi:10.1002/ange.201103899 · Cited by 90

TET2 Mutations Affect Non-CpG Island DNA Methylation at Enhancers and Transcription Factor–Binding Sites in Chronic Myelomonocytic Leukemia

Yamazaki, J., Jelı́nek, J., Lu, Y., Cesaroni, M., Madžo, J., Neumann, F., He, R. L., Taby, R. F., Vasanthakumar, A., Macrae, T. A., et al. (2015) · Cancer Research · doi:10.1158/0008-5472.can-14-0739 · Cited by 90

Ten-eleven translocation (Tet) and thymine DNA glycosylase (TDG), components of the demethylation pathway, are direct targets of miRNA-29a

Zhang, P., Huang, B., Xu, X. Z. S., & Sessa, W. C. (2013) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2013.06.082 · Cited by 88

Dynamic changes in 5-hydroxymethylation signatures underpin early and late events in drug exposed liver

Thomson, J. P., Hunter, J. M., Lempiäinen, H., Müller, A., Terranova, R., Moggs, J. G., & Meehan, R. R. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt232 · Cited by 87

5-Hydroxymethylcytosine – the elusive epigenetic mark in mammalian DNA

Kriukienė, E., Liutkevičiūtė, Z., & Klimašauskas, S. (2012) · Chemical Society Reviews · doi:10.1039/c2cs35104h · Cited by 92

TET-dependent regulation of retrotransposable elements in mouse embryonic stem cells

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Epigenetic Modifications in the Biology of Nonalcoholic Fatty Liver Disease

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