The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.
Neocortical excitation/inhibition balance in information processing and social dysfunction
Open accessAbstract
Severe behavioural deficits in psychiatric diseases such as autism and schizophrenia have been hypothesized to arise from elevations in the cellular balance of excitation and inhibition (E/I balance) within neural microcircuitry. This hypothesis could unify diverse streams of pathophysiological and genetic evidence, but has not been susceptible to direct testing. Here we design and use several novel optogenetic tools to causally investigate the cellular E/I balance hypothesis in freely moving mammals, and explore the associated circuit physiology. Elevation, but not reduction, of cellular E/I balance within the mouse medial prefrontal cortex was found to elicit a profound impairment in cellular information processing, associated with specific behavioural impairments and increased high-frequency power in the 30-80 Hz range, which have both been observed in clinical conditions in humans. Consistent with the E/I balance hypothesis, compensatory elevation of inhibitory cell excitability partially rescued social deficits caused by E/I balance elevation. These results provide support for the elevated cellular E/I balance hypothesis of severe neuropsychiatric disease-related symptoms.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Conventionally used AAV backbones which include a commonly used neuronal expression cassette composed of 1.3 kb CaMKIIα promoter (which shows comparable expression efficiency with 0.4 kb CaMKIIα promoter [10] used in CWB), WPRE, and human growth hormone polyadenylation signal [23-25] has a capacity of 2.4 kb.”
From Optimization of AAV expression cassettes to improve packaging capacity and transgene expression in neurons (2014) · cites this paper as [24]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“Importantly, alterations in the balance between excitatory and inhibitory signalling in neural micro-circuitry have been implicated in social deficits as seen in ASD and SCZ (Yizhar et al. 2011).”
From Neurexin1α knockout in rats causes aberrant social behaviour: relevance for autism and schizophrenia (2025) · cites this paper as Yizhar et al. 2011
The cited source says what the claim attributes to it.
In the citing paper
“Changes in PFC network activity directly affect cognitive and social skills”
From Social Play Behavior Is Critical for the Development of Prefrontal Inhibitory Synapses and Cognitive Flexibility in Rats (2022) · cites this paper as Yizhar et al., 2011
The check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“Elevated levels of the repressive H3K27me3 mark, catalyzed by the histone methyltransferase EZH2, have also been observed in chronic stress models.”
From Histone modifications and depression: epigenetic mechanisms, therapeutic targets, and translational outlook (2026) · cites this paper as Yizhar et al., 2011
Experimental — accuracy not yet measuredThe check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“These increases are associated with reduced expression of neuroplasticity-related genes, including CREB and enzymes involved in GABA synthesis (Yizhar et al., 2011).”
From Histone modifications and depression: epigenetic mechanisms, therapeutic targets, and translational outlook (2026) · cites this paper as Yizhar et al., 2011
Experimental — accuracy not yet measured
The check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“Psychotic symptoms may be seen as attempts to garner some advantage, perhaps by convincing others of their veracity (113).”
From The Predictive Coding Account of Psychosis (2018) · cites this paper as [113]
Experimental — accuracy not yet measuredIn the citing paper
“Defective synaptic function leading to an excitation–inhibition (E/I) imbalance is commonly invoked as one possible explanation for ASD (Rubenstein and Merzenich 2003), and is supported by evidence in humans and rodents (Yizhar et al. 2011; Hashemi et al. 2017; Selimbeyoglu et al. 2017).”
From Dysfunctional Autism Risk Genes Cause Circuit-Specific Connectivity Deficits With Distinct Developmental Trajectories (2018) · cites this paper as Yizhar et al. 2011
In the citing paper
“Yizhar et al. (2011) have shown that increased neural excitability can lead to impairments in social interaction and cognitive functions in a mouse model of autism.”
From From early markers to neuro-developmental mechanisms of autism (2014) · cites this paper as Yizhar et al., 2011
In the citing paper
“changes in mTOR-autophagy signaling and spine pruning defects may represent a secondary mechanism in response to an imbalance between excitatory and inhibitory neurotransmission”
From Loss of mTOR-Dependent Macroautophagy Causes Autistic-like Synaptic Pruning Deficits (2014) · cites this paper as Yizhar et al., 2011
In the citing paper
“Recently, it was demonstrated that increasing neural excitation is sufficient to disrupt cognition and sociability”
From Pathogenic SYNGAP1 Mutations Impair Cognitive Development by Disrupting Maturation of Dendritic Spine Synapses (2012) · cites this paper as Yizhar et al., 2011
In the citing paper
“E/I imbalance is a defining neurophysiological feature of neurodevelopmental disorders (Rubenstein and Merzenich, 2003) and elevated excitation is sufficient to disrupt cognition and sociability (Yizhar et al., 2011).”
From Pathogenic SYNGAP1 Mutations Impair Cognitive Development by Disrupting Maturation of Dendritic Spine Synapses (2012) · cites this paper as Yizhar et al., 2011
In the citing paper
“both constant and high frequency laser stimulation of PV cINs expressing the red-shifted opsin C1V1 in brain slices40 resulted in firing time-locked to the stimulus.”
From Viral manipulation of functionally distinct interneurons in mice, non-human primates and humans (2020) · cites this paper as [40]
In the citing paper
“In mice, both congenital knockout and haploinsufficiency of Shank3 leads to diminished social interest in others and is associated with the disruption of cortical and subcortical circuits thought to be involved in ASD 22–26 and its ontogenesis 22,25,27,28.”
From Reduced sociability and social agency encoding in adult Shank3-mutant mice are restored through gene re-expression in real time (2021) · cites this paper as [26]
In the citing paper
“Here, we used microelectrode arrays that were implanted in the animal’s mPFC (Extended Data Fig. 1b), an area suggested to be involved in social behavior 1,7,12,26,34 and disorders such as ASD 14,21,35,36.”
From Reduced sociability and social agency encoding in adult Shank3-mutant mice are restored through gene re-expression in real time (2021) · cites this paper as [26]
In the citing paper
“we chose to use the Stabilized Step Function Opsin (SSFO), which upon activation by a single light pulse leads to prolonged (approximately 30 min) sub-threshold depolarization (Yizhar et al., 2011), sensitizing the cell to afferent inputs rather than inducing firing directly.”
From Wireless Optogenetic Stimulation of Oxytocin Neurons in a Semi-natural Setup Dynamically Elevates Both Pro-social and Agonistic Behaviors (2020) · cites this paper as Yizhar et al., 2011
In the citing paper
“This provided an estimated 1.75 mm3 of brain tissue being illuminated with light intensity above 8 microwatt×mm–2, the lowest reported functional light intensity for SSFO”
From Wireless Optogenetic Stimulation of Oxytocin Neurons in a Semi-natural Setup Dynamically Elevates Both Pro-social and Agonistic Behaviors (2020) · cites this paper as Yizhar et al., 2011
In the citing paper
“Neural circuit manipulation in combination with neural recordings provide direct evidence that elevated mPFC activity results in ASD-related phenotypes, whereas decreasing mPFC activity is sufficient to rescue abnormal behaviors in ASD models22,23,24.”
From Regulation of autism-relevant behaviors by cerebellar-prefrontal cortical circuits (2020) · cites this paper as [23]
In the citing paper
“Our integrative analyses have allowed us to: (a) identify disease-relevant cell types for a disorder; (b) identify unique dysfunctions in individual cohorts (due to impact on very specific subtypes); (c) deduce a potential functional basis of a disorder (such as excitatory/inhibitory balance48,49, lack of myelination50 etc.) based on the cells affected.”
From Cell type-specific transcriptional programs in mouse prefrontal cortex during adolescence and addiction (2019) · cites this paper as [49]
In the citing paper
“Disruption of the ratio of excitation and inhibition (E/I balance) can give rise to profound behavioral deficits and may play a key role in serious mental illnesses such as schizophrenia (Yizhar et al. 2011).”
From Linking microcircuit dysfunction to cognitive impairment: Effects of disinhibition associated with schizophrenia in a cortical working memory model (2014) · cites this paper as Yizhar et al. 2011
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Shrestha, S., & Offer, S. M. (2016) · Medical Epigenetics · doi:10.1159/000444713 · Cited by 8,951
Model of autism: increased ratio of excitation/inhibition in key neural systems
Rubenstein, J. L. R., & Merzenich, M. M. (2003) · Genes, Brain and Behavior · doi:10.1034/j.1601-183x.2003.00037.x · Cited by 2,768
Neurodegenerative Disorders: Parkinson's Disease and Huntington's Disease
Hague, S., Klaffke, S., & Bandmann, O. (2006) · IMPERIAL COLLEGE PRESS eBooks · doi:10.1142/9781860948961_0007 · Cited by 2,767
Parvalbumin neurons and gamma rhythms enhance cortical circuit performance
Sohal, V. S., Zhang, F., Yizhar, O., & Deisseroth, K. (2009) · Nature · doi:10.1038/nature07991 · Cited by 2,606
Self-citationCortical inhibitory neurons and schizophrenia
Lewis, D. A., Hashimoto, T., & Volk, D. W. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1648 · Cited by 2,297
Optogenetics in neural systems
Yizhar, O., Fenno, L. E., Davidson, T. J., Mogri, M., & Deisseroth, K. (2011) · Neuron · doi:10.1016/j.neuron.2011.06.004 · Cited by 1,881
Self-citationNeuroligins and neurexins link synaptic function to cognitive disease
Südhof, T. C. (2008) · Nature · doi:10.1038/nature07456 · Cited by 1,849
Rare Structural Variants Disrupt Multiple Genes in Neurodevelopmental Pathways in Schizophrenia
Walsh, T., McClellan, J. M., McCarthy, S. E., Addington, A. M., Pierce, S. B., Cooper, G. M., Nord, A. S., Kusenda, M., Malhotra, D., Bhandari, A., et al. (2008) · Science · doi:10.1126/science.1155174 · Cited by 1,800
Moy, S. S., Nadler, J. J., Perez, A., Barbaro, R. P., Johns, J. M., Magnuson, T. R., Piven, J., & Crawley, J. N. (2004) · Genes, Brain and Behavior · doi:10.1111/j.1601-1848.2004.00076.x · Cited by 1,522
Neural substrates of awakening probed with optogenetic control of hypocretin neurons
Adamantidis, A. R., Zhang, F., Aravanis, A. M., Deisseroth, K., & de Lecea, L. (2007) · Nature · doi:10.1038/nature06310 · Cited by 1,341
Self-citation
Cited by
Sorted by citations
Items 601–700 of 1,015
Optogenetics to study the circuits of fear- and depression-like behaviors: A critical analysis
Belzung, C., Turiault, M., & Griebel, G. (2014) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2014.04.002 · Cited by 65
Molecular Tools and Approaches for Optogenetics
Yuan, M., & Zhang, F. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.02.019 · Cited by 68
Sublinear integration underlies binocular processing in primary visual cortex
Longordo, F., To, M., Ikeda, K., & Stuart, G. J. (2013) · Nature Neuroscience · doi:10.1038/nn.3394 · Cited by 67
Cortical interneuron dysfunction in epilepsy associated with autism spectrum disorders
Jacob, J. (2015) · Epilepsia · doi:10.1111/epi.13272 · Cited by 65
Schmid, F., Wachsmuth, L., Schwalm, M., Prouvot, P.-H., Jubal, E. R., Fois, C., Pramanik, G. K., Zimmer, C., Faber, C., & Stroh, A. (2015) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x15619428 · Cited by 63
Optimal compensation for neuron loss
Barrett, D. G. T., Denève, S., & Machens, C. K. (2016) · eLife · doi:10.7554/elife.12454 · Cited by 68
Haam, J., Zhou, J., Cui, G., & Yakel, J. L. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1712538115 · Cited by 66
Sakaguchi, T., Iwasaki, S., Okada, M., Okamoto, K., & Ikegaya, Y. (2018) · Nature Communications · doi:10.1038/s41467-018-05894-y · Cited by 63
Pai, E. L.-L., Vogt, D. L., Clemente-Perez, A., McKinsey, G. L., Cho, F. S., Hu, J. S., Wimer, M., Paul, A., Darbandi, S. F., Pla, R., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.01.031 · Cited by 66
Self-citationRegional GABA Concentrations Modulate Inter-network Resting-state Functional Connectivity
Chen, X., Fan, X., Hu, Y., Zuo, C., Whitfield-Gabrieli, S., Holt, D., Gong, Q., Yang, Y., Pizzagalli, D. A., Du, F., et al. (2019) · Cerebral Cortex · doi:10.1093/cercor/bhy059 · Cited by 62
Cognition-Emotion Dysinteraction in Schizophrenia
Anticevic, A., & Corlett, P. R. (2012) · Frontiers in Psychology · doi:10.3389/fpsyg.2012.00392 · Cited by 66
Optogenetic micro-electrocorticography for modulating and localizing cerebral cortex activity
Richner, T. J., Thongpang, S., Brodnick, S. K., Schendel, A. A., Falk, R., Krugner-Higby, L. A., Pashaie, R., & Williams, J. C. (2014) · Journal of Neural Engineering · doi:10.1088/1741-2560/11/1/016010 · Cited by 63
Let There Be Light—Optoprobes for Neural Implants
Alt, M. T., Fiedler, E., Rudmann, L., Ordonez, J. S., Ruther, P., & Stieglitz, T. (2016) · Proceedings of the IEEE · doi:10.1109/jproc.2016.2577518 · Cited by 63
Optogenetics and its application in neural degeneration and regeneration
Xu, X., Ordaz, J. D., & Wu, W. (2017) · Neural Regeneration Research · doi:10.4103/1673-5374.213532 · Cited by 63
Presynaptic LRP4 promotes synapse number and function of excitatory CNS neurons
Mosca, T. J., Luginbuhl, D. J., Wang, I. E., & Luo, L. (2017) · eLife · doi:10.7554/elife.27347 · Cited by 65
Ohta, K., Suzuki, S., Warita, K., Sumitani, K., Tenkumo, C., Ozawa, T., Ujihara, H., Kusaka, T., & Miki, T. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.112306 · Cited by 64
Qin, L., Williams, J. B., Tan, T., Liu, T., Cao, Q., Ma, K., & Yan, Z. (2021) · Nature Communications · doi:10.1038/s41467-021-26972-8 · Cited by 64
Oxytocin Receptors Regulate Social Preference in Zebrafish
Landin, J., Hovey, D., Xu, B., Lagman, D., Zettergren, A., Larhammar, D., Kettunen, P., & Westberg, L. (2020) · Scientific Reports · doi:10.1038/s41598-020-61073-4 · Cited by 65
Ike, K. G. O., de Boer, S. F., Buwalda, B., & Kas, M. J. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.06.030 · Cited by 64
Han, Y. M. Y., Chan, M. M. Y., Shea, C. K., Lai, O. L.-H., Krishnamurthy, K., Cheung, M., & Chan, A. S.-Y. (2022) · Brain stimulation · doi:10.1016/j.brs.2022.02.004 · Cited by 64
The role of neuronavigation in TMS–EEG studies: Current applications and future perspectives
Lioumis, P., & Rosanova, M. (2022) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2022.109677 · Cited by 61
Anteromedial thalamus gates the selection and stabilization of long-term memories
Toader, A. C., Regalado, J. M., Li, Y. R., Terceros, A. A., Yadav, N., Kumar, S., Satow, S., Hollunder, F., Bonito-Oliva, A., & Rajasethupathy, P. (2023) · Cell · doi:10.1016/j.cell.2023.02.024 · Cited by 68
Makinodan, M., Ikawa, D., Yamamuro, K., Yamashita, Y., Toritsuka, M., Kimoto, S., Yamauchi, T., Okumura, K., Komori, T., Fukami, S.-I., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-05632-2 · Cited by 65
Dalton, B., Bartholdy, S., Campbell, I. C., & Schmidt, U. H. (2018) · Current Neuropharmacology · doi:10.2174/1570159x16666180108111532 · Cited by 61
In vivo sub-millisecond two-photon optogenetics with temporally focused patterned light
Chen, I.-W., Ronzitti, E., Lee, B. R., Daigle, T. L., Dalkara, D., Zeng, H., Emiliani, V., & Papagiakoumou, E. I. (2019) · Journal of Neuroscience · doi:10.1523/jneurosci.1785-18.2018 · Cited by 71
The Current View on the Paradox of Pain in Autism Spectrum Disorders
Bogdanova, O. V., Bogdanov, V. B., Pizano, A., Bouvard, M. P., Cazalets, J., Mellen, N. M., & Amestoy, A. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.910824 · Cited by 70
Yang, J., Zhang, J., Chen, X., Geng, H.-Y., Ye, M., Spitzer, N. C., Luo, J., Duan, S., & Li, X.-M. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.1584-13.2013 · Cited by 62
Combined transcranial magnetic stimulation and electroencephalography: Its past, present and future
Daskalakis, Z. J., Farzan, F., Radhu, N., & Fitzgerald, P. B. (2012) · Brain Research · doi:10.1016/j.brainres.2012.04.045 · Cited by 67
Donegan, J. J., Tyson, J. A., Branch, S. Y., Beckstead, M. J., Anderson, S. A., & Lodge, D. J. (2016) · Molecular Psychiatry · doi:10.1038/mp.2016.121 · Cited by 60
Simultaneous high-speed imaging and optogenetic inhibition in the intact mouse brain
Bovetti, S., Moretti, C., Zucca, S., Maschio, M. D., Bonifazi, P., & Fellin, T. (2017) · Scientific Reports · doi:10.1038/srep40041 · Cited by 65
Conserved features of anterior cingulate networks support observational learning across species
Burgos-Robles, A., Gothard, K. M., Monfils, M., Morozov, A., & Vicentic, A. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.09.009 · Cited by 64
Direct neural perturbations reveal a dynamical mechanism for robust computationPreprint
O’Shea, D. J., Duncker, L., Goo, W., Sun, X., Vyas, S., Trautmann, E. M., Diester, I., Ramakrishnan, C., Deisseroth, K. A., Sahani, M., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.12.16.520768 · Cited by 65
Self-citationMao, W., Watanabe, T., Cho, S., Frost, J. L., Truong, T., Zhao, X., & Futai, K. (2015) · European Journal of Neuroscience · doi:10.1111/ejn.12877 · Cited by 59
Layer‐specific excitation/inhibition balances during neuronal synchronization in the visual cortex
Adesnik, H. (2018) · The Journal of Physiology · doi:10.1113/jp274986 · Cited by 62
Anderson, E. M., Gomez, D. M., Caccamise, A. J., McPhail, D., & Hearing, M. C. (2019) · Neurobiology of Stress · doi:10.1016/j.ynstr.2019.100152 · Cited by 59
Hui, K. K., Takashima, N., Watanabe, A., Chater, T. E., Matsukawa, H., Nekooki-Machida, Y., Nilsson, P., Endo, R., Goda, Y., Saido, T. C., et al. (2019) · Science Advances · doi:10.1126/sciadv.aau8237 · Cited by 61
Concentrations of Cortical GABA and Glutamate in Young Adults With Autism Spectrum Disorder
Kolodny, T., Schallmo, M., Gerdts, J. A., Edden, R. A. E., Bernier, R., & Murray, S. O. (2020) · Autism Research · doi:10.1002/aur.2300 · Cited by 59
Canetta, S. E., Holt, E. S., Benoit, L. J., Teboul, E., Sahyoun, G. M., Ogden, R. T., Harris, A. Z., & Kellendonk, C. (2022) · eLife · doi:10.7554/elife.80324 · Cited by 59
Rein, B., Tan, T., Yang, F., Wang, W., Williams, J., Zhang, F., Mills, A., & Yan, Z. (2021) · Molecular Psychiatry · doi:10.1038/s41380-020-0693-9 · Cited by 58
Prospects for Optogenetic Augmentation of Brain Function
Jarvis, S., & Schultz, S. R. (2015) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2015.00157 · Cited by 58
Bianciardi, B., & Uhlhaas, P. J. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.02.005 · Cited by 59
Noh, K., Cho, W.-H., Lee, B. H., Kim, D. W., Kim, Y. S., Park, K., Hwang, M., Barcelon, E. E., Cho, Y. K., Lee, C. J., et al. (2023) · Nature Neuroscience · doi:10.1038/s41593-023-01406-4 · Cited by 58
Loss of α1,6-Fucosyltransferase Decreases Hippocampal Long Term Potentiation
Gu, W., Fukuda, T., Isaji, T., Hang, Q., Lee, H.-H., Sakai, S., Morise, J., Mitoma, J., Higashi, H., Taniguchi, N., et al. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.579938 · Cited by 58
Two-photon imaging of neural population activity in zebrafish
Renninger, S. L., & Orger, M. B. (2013) · Methods · doi:10.1016/j.ymeth.2013.05.016 · Cited by 62
Neuromodulation and neurofeedback treatments in eating disorders and obesity
Dalton, B., Campbell, I. C., & Schmidt, U. H. (2017) · Current Opinion in Psychiatry · doi:10.1097/yco.0000000000000361 · Cited by 58
Predictive learning: its key role in early cognitive development
Nagai, Y. (2019) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2018.0030 · Cited by 65
Improved Cognitive Promotion through Accelerated Magnetic Stimulation
Wu, X., Wang, L., Geng, Z., Wei, L., Yan, Y., Xie, C., Chen, X., Ji, G., Tian, Y., & Wang, K. (2021) · eNeuro · doi:10.1523/eneuro.0392-20.2020 · Cited by 57
Zemestani, M., hosseinpanahi, O., Salehinejad, M. A., & Nitsche, M. A. (2022) · Autism Research · doi:10.1002/aur.2803 · Cited by 57
Solving brain circuit function and dysfunction with computational modeling and optogenetic fMRI
Lee, J. H., Liu, Q., & Dadgar‐Kiani, E. (2022) · Science · doi:10.1126/science.abq3868 · Cited by 59
Dual Color Neural Activation and Behavior Control with Chrimson and CoChR in Caenorhabditis elegans
Schild, L. C., & Glauser, D. A. (2015) · Genetics · doi:10.1534/genetics.115.177956 · Cited by 57
Kohl, C., Riccio, O., Grosse, J., Zanoletti, O., Fournier, C., Schmidt, M. V., & Sandi, C. (2013) · PLoS ONE · doi:10.1371/journal.pone.0056871 · Cited by 59
ChR2 Mutants at L132 and T159 with Improved Operational Light Sensitivity for Vision Restoration
Pan, Z., Ganjawala, T. H., Lu, Q., Ivanova, E., & Zhang, Z. (2014) · PLoS ONE · doi:10.1371/journal.pone.0098924 · Cited by 57
Liao, W., Gandal, M. J., Ehrlichman, R. S., Siegel, S. J., & Carlson, G. C. (2012) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.12.048 · Cited by 60
Forebrain-specific ablation of phospholipase Cγ1 causes manic-like behavior
Yang, Y. R., Jung, J. H., Kim, S.-J., Hamada, K., Suzuki, A., Kim, H. J., Lee, J. H., Kwon, O.-B., Lee, Y. K., Kim, J., et al. (2017) · Molecular Psychiatry · doi:10.1038/mp.2016.261 · Cited by 57
Sobue, A., Ito, N., Nagai, T., Wei, S., Hada, K., Nakajima, A., Murakami, Y., Mouri, A., Yamamoto, Y., Nabeshima, T., et al. (2018) · Glia · doi:10.1002/glia.23299 · Cited by 57
Ankyrins: Roles in synaptic biology and pathology
Smith, K. R., & Penzes, P. (2018) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2018.04.010 · Cited by 57
Letellier, M., Szíber, Z., Chamma, I., Saphy, C., Papasideri, I., Tessier, B., Sainlos, M., Czöndör, K., & Thoumine, O. R. (2018) · Nature Communications · doi:10.1038/s41467-018-06220-2 · Cited by 59
Augmented Reticular Thalamic Bursting and Seizures in Scn1a-Dravet Syndrome
Makinson, S. R., Clemente-Perez, A., Higashikubo, B. T., Cho, F. S., Holden, S. S., Bennett, E., Chkhaidze, A., Rooda, O. H. J. E., Cornet, M., Hoebeek, F. E., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2018.12.018 · Cited by 57
Self-citationInvestigational and Therapeutic Applications of Transcranial Magnetic Stimulation in Schizophrenia
Mehta, U. M., Naik, S. S., Thanki, M. V., & Thirthalli, J. (2019) · Current Psychiatry Reports · doi:10.1007/s11920-019-1076-2 · Cited by 59
Olfactory modulation of the medial prefrontal cortex circuitry: Implications for social cognition
Bhattarai, J. P., Etyemez, S., Jaaro-Peled, H., Janke, E., Tolosa, U. D. L., Kamiya, A., Gottfried, J. A., Sawa, A., & Ma, M. (2021) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2021.03.022 · Cited by 57
Fereshetyan, K., Chavushyan, V. A., Danielyan, M., & Yenkoyan, K. B. (2021) · Scientific Reports · doi:10.1038/s41598-021-02994-6 · Cited by 58
Treating Schizophrenia With the Diuretic Bumetanide
Lemonnier, É., Lazartigues, A., & Ben‐Ari, Y. (2016) · Clinical Neuropharmacology · doi:10.1097/wnf.0000000000000136 · Cited by 56
Gu, H., Hu, Y., Chen, X., Yong He, A., & Yang, Y. (2018) · NeuroImage · doi:10.1016/j.neuroimage.2018.10.055 · Cited by 59
Inhibitory interneurons mediate autism-associated behaviors via 4E-BP2
Wiebe, S. A., Nagpal, A., Truong, V. T., Park, J., Skalecka, A., He, A. J., Gamache, K., Khoutorsky, A., Gantois, I., & Sonenberg, N. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1908126116 · Cited by 58
Wietek, J., Broser, M., Krause, B. S., & Hegemann, P. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.699637 · Cited by 55
Self-citationLeft brain cortical activity modulates stress effects on social behavior
Lee, E., Hong, J., Park, Y.-G., Chae, S., Kim, Y. D., & Kim, D. (2015) · Scientific Reports · doi:10.1038/srep13342 · Cited by 58
Optogenetic manipulation of neural and non‐neural functions
Yawo, H., Asano, T., Sakai, S., & Ishizuka, T. (2013) · Development Growth & Differentiation · doi:10.1111/dgd.12053 · Cited by 59
The Developing Utility of Zebrafish Models for Cognitive Enhancers Research
Stewart, A., & Kalueff, A. V. (2012) · Current Neuropharmacology · doi:10.2174/157015912803217323 · Cited by 56
Information gain in the brain's resting state: A new perspective on autism
Velázquez, J. L. P., & Galán, R. F. (2013) · Frontiers in Neuroinformatics · doi:10.3389/fninf.2013.00037 · Cited by 61
Optogenetics and Epilepsy: Past, Present and Future
Paz, J. T., & Huguenard, J. R. (2015) · Epiliepsy currents/Epilepsy currents · doi:10.5698/1535-7597-15.1.34 · Cited by 55
Self-citationKanner, A. M., Scharfman, H. E., Jetté, N., Anagnostou, E. A., Bernard, C., Camfield, C., CAMFIELD, P. R., Legg, K. T., Dinstein, I., Giacobbe, P., et al. (2017) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2017.09.014 · Cited by 57
Long-term all-optical interrogation of cortical neurons in awake-behaving nonhuman primates
Ju, N., Jiang, R., Macknik, S. L., Martínez‐Conde, S., & Tang, S. (2018) · PLoS Biology · doi:10.1371/journal.pbio.2005839 · Cited by 59
Morphometric analysis and neuroanatomical mapping of the zebrafish brain
Gupta, T., Marquart, G. D., Horstick, E. J., Tabor, K. M., Pajevic, S., & Burgess, H. A. (2018) · Methods · doi:10.1016/j.ymeth.2018.06.008 · Cited by 55
Malik, R., Pai, E. L.-L., Rubin, A. N., Stafford, A. M., Angara, K., Minasi, P., Rubenstein, J. L. R., Sohal, V. S., & Vogt, D. L. (2019) · Nature Communications · doi:10.1038/s41467-019-12962-4 · Cited by 55
Self-citationBijlsma, A., Omrani, A., Spoelder, M., Verharen, J. P. H., Bauer, L., Cornelis, C., de Zwart, B., van Dorland, R., Vanderschuren, L. J. M. J., & Wierenga, C. J. (2022) · The Journal of Neuroscience · doi:10.1523/jneurosci.0524-22.2022 · Cited by 54
Alcohol induces input-specific aberrant synaptic plasticity in the rat dorsomedial striatum
Ma, T., Barbee, B. R., Wang, X., & Wang, J. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.05.014 · Cited by 54
Port, R. G., Gajewski, C. R., Krizman, E. N., Dow, H. C., Hirano, S., Brodkin, E. S., Carlson, G. C., Robinson, M. B., Roberts, T. P. L., & Siegel, S. J. (2017) · Neurobiology of Disease · doi:10.1016/j.nbd.2017.08.013 · Cited by 55
Structural basis for ion selectivity in potassium-selective channelrhodopsins
Tajima, S., Kim, Y. S., Fukuda, M., Jo, Y., Wang, P. Y., Paggi, J. M., Inoue, M., Byrne, E. F. X., Kishi, K. E., Nakamura, S., et al. (2023) · Cell · doi:10.1016/j.cell.2023.08.009 · Cited by 56
Self-citationThe influence of cortical activity on perception depends on behavioral state and sensory context
Russell, L. E., Fişek, M., Yang, Z., Tan, L. P., Packer, A. M., Dalgleish, H. W. P., Chettih, S. N., Harvey, C. D., & Häusser, M. (2024) · Nature Communications · doi:10.1038/s41467-024-46484-5 · Cited by 59
Possible functional links among brain- and skull-related genes selected in modern humans
Benítez‐Burraco, A., & Boeckx, C. A. (2015) · Frontiers in Psychology · doi:10.3389/fpsyg.2015.00794 · Cited by 55
Jin, Z., Bhandage, A. K., Bazov, I., Kononenko, O., Bakalkin, G. Y., Korpi, E. R., & Birnir, B. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00011 · Cited by 54
Nakamura, T., Arima‐Yoshida, F., Sakaue, F., Nasu‐Nishimura, Y., Takeda, Y., Matsuura, K., Akshoomoff, N. A., Mattson, S. N., Grossfeld, P., Manabe, T., et al. (2016) · Nature Communications · doi:10.1038/ncomms10861 · Cited by 58
Bergs, A. C. F., Schultheis, C., Fischer, E., Tsunoda, S. P., Erbguth, K., Husson, S. J., Govorunova, E. G., Spudich, J. L., Nagel, G., GOTTSCHALK, A. R., et al. (2018) · PLoS ONE · doi:10.1371/journal.pone.0191802 · Cited by 54
Transient Cognitive Impairment in Epilepsy
Landi, S., Petrucco, L., Sicca, F., & Ratto, G. M. (2019) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00458 · Cited by 57
Hyperexcitability and homeostasis in fragile X Syndrome.
Liu, X., Kumar, V., Tsai, N.-P., & Auerbach, B. D. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2021.805929 · Cited by 53
Optogenetic reactivation of prefrontal social neural ensembles mimics social buffering of fear
Gutzeit, V. A., Ahuna, K., Santos, T. L., Cunningham, A. M., Rooney, M. S., Zamora, A., Denny, C. A., & Donaldson, Z. R. (2020) · Neuropsychopharmacology · doi:10.1038/s41386-020-0631-1 · Cited by 55
Sadeh, S., & Clopath, C. (2021) · Science Advances · doi:10.1126/sciadv.abg8411 · Cited by 57
Fiksinski, A., Hoftman, G. D., Vorstman, J. A. S., & Bearden, C. E. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01783-5 · Cited by 56
Mechanisms of Functional Hypoconnectivity in the Medial Prefrontal Cortex ofMecp2Null Mice
Sceniak, M. P., Lang, M., Enomoto, A. C., Howell, C., Hermes, D. J., & Katz, D. M. (2015) · Cerebral Cortex · doi:10.1093/cercor/bhv002 · Cited by 53
Tan, T., Wang, W., Xu, H., Huang, Z., Wang, Y. T., & Dong, Z. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00046 · Cited by 53
Nolan, A., Hennessy, E., Krukowski, K., Guglielmetti, C., Chaumeil, M. M., Sohal, V. S., & Rosi, S. (2018) · Journal of Neurotrauma · doi:10.1089/neu.2018.5731 · Cited by 53
Self-citationLee, S., Lee, E., Kim, R., Kim, J., Lee, S., Park, H., Yang, E., Kim, H., & Kim, E. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00209 · Cited by 54
Wilson, J. E., Trumbo, M., Wilson, J. K., & Tesche, C. D. (2018) · Journal of Neural Transmission · doi:10.1007/s00702-018-1938-5 · Cited by 55
Domanski, A. P. F., Booker, S. A., Wyllie, D. J. A., Isaac, J. T. R., & Kind, P. C. (2019) · Nature Communications · doi:10.1038/s41467-019-12736-y · Cited by 59
Camp, C. R., & Yuan, H. (2019) · European Journal of Paediatric Neurology · doi:10.1016/j.ejpn.2019.12.007 · Cited by 54
T‐Brain‐1 – A Potential Master Regulator in Autism Spectrum Disorders
Chuang, H., Huang, T., & Hsueh, Y. (2015) · Autism Research · doi:10.1002/aur.1456 · Cited by 56
Establishing causality for dopamine in neural function and behavior with optogenetics
Steinberg, E. E., & Janak, P. H. (2012) · Brain Research · doi:10.1016/j.brainres.2012.09.036 · Cited by 56
Natural photoreceptors and their application to synthetic biology
Schmidt, D., & Cho, Y. K. (2014) · Trends in biotechnology · doi:10.1016/j.tibtech.2014.10.007 · Cited by 53
Holographic imaging and photostimulation of neural activity
Yang, W., & Yuste, R. (2018) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2018.03.006 · Cited by 52
Thalman, C., Horta, G., Qiao, L., Endle, H., Tegeder, I., Cheng, H., Laube, G., Sigurdsson, T., Hauser, M. J., Tenzer, S., et al. (2018) · Molecular Psychiatry · doi:10.1038/s41380-018-0053-1 · Cited by 52
Metadata
- Authors
- Yizhar, O., Fenno, L. E., Prigge, M., Schneider, F., Davidson, T. J., O’Shea, D. J., Sohal, V. S., Goshen, I., Finkelstein, J., Paz, J. T., Stehfest, K., Fudim, R., Ramakrishnan, C., Huguenard, J. R., Hegemann, P., & Deisseroth, K.
- Affiliations
- Stanford University (US)
- Humboldt-Universität zu Berlin (DE)
- University of California, San Francisco (US)
- Stanford Medicine (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Yizhar, Ofer
- Hegemann, Peter
- Deisseroth, Karl
- ORCID
- Venue
- Nature
- Published
- 2011-07-27
- Volume
- 477
- Issue
- 7363
- Pages
- 171-178
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC4155501
- OpenAlex
- W2072652550
- Cited by
- 2,454
- References
- 52
- Citations by year
- 2026: 138 · 2025: 154 · 2024: 154 · 2023: 193 · 2022: 179 · 2021: 202 · 2020: 183 · 2019: 172 · 2018: 186 · 2017: 165 · 2016: 152 · 2015: 173 · 2014: 143 · 2013: 129 · 2012: 107
- FWCI
- 52.83
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institutes of Health (DP1OD000616)
- National Institute of Mental Health (R01MH075957, R01MH086373)
- National Institute of Neurological Disorders and Stroke (R01NS034774, R01NS006477)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- excitation-inhibition balance, medial prefrontal cortex, social dysfunction, autism spectrum disorder, schizophrenia, neuropsychiatric disorders, optogenetics, inhibitory interneurons, neuronal excitability, high-frequency oscillations, social behavior, learning behavior
- MeSH terms
- Animals, Autistic Disorder, Mental Disorders, Disease Models, Animal, Hippocampus, Humans, Learning, Models, Neurological, Motor Activity, Neural Inhibition, Neurons, Schizophrenia, Social Behavior, Prefrontal Cortex, Mice, Opsins, HEK293 Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
