The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Genome sequencing reveals insights into physiology and longevity of the naked mole rat
Open accessAbstract
The mouse-sized naked mole rat (Heterocephalus glaber) is a very unusual mammal. It is a social animal, living in groups in burrows beneath arid African deserts. It can live for 30 or more years in atmospheres with low oxygen and high carbon dioxide, and is remarkably resistant to cancer. So the genome sequence, published in this issue, might be expected to contain some intriguing characteristics. Analysis of the genome and its transcriptome reveals unusual genomic features and molecular adaptations including strategies for improved genome stability, low mutation rate and improved protein maintenance. The data also reveal molecular adaptations consistent with poor visual function, poikilothermy, hairlessness, circadian rhythms, taste sensing and insensitivity to low oxygen. The naked mole rat (Heterocephalus glaber) is a strictly subterranean, extraordinarily long-lived eusocial mammal1. Although it is the size of a mouse, its maximum lifespan exceeds 30 years, making this animal the longest-living rodent. Naked mole rats show negligible senescence, no age-related increase in mortality, and high fecundity until death2. In addition to delayed ageing, they are resistant to both spontaneous cancer and experimentally induced tumorigenesis3,4. Naked mole rats pose a challenge to the theories that link ageing, cancer and redox homeostasis. Although characterized by significant oxidative stress5, the naked mole rat proteome does not show age-related susceptibility to oxidative damage or increased ubiquitination6. Naked mole rats naturally reside in large colonies with a single breeding female, the ‘queen’, who suppresses the sexual maturity of her subordinates7. They also live in full darkness, at low oxygen and high carbon dioxide concentrations8, and are unable to sustain thermogenesis9 nor feel certain types of pain10,11. Here we report the sequencing and analysis of the naked mole rat genome, which reveals unique genome features and molecular adaptations consistent with cancer resistance, poikilothermy, hairlessness and insensitivity to low oxygen, and altered visual function, circadian rythms and taste sensing. This information provides insights into the naked mole rat’s exceptional longevity and ability to live in hostile conditions, in the dark and at low oxygen. The extreme traits of the naked mole rat, together with the reported genome and transcriptome information, offer opportunities for understanding ageing and advancing other areas of biological and biomedical research.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Interestingly, the genome of the longest-lived rodent, the naked mole rat, contains fewer retrotransposons than other rodent genomes108; whereas the genomes of long-lived bats are replete with transposable elements109.”
From The role of retrotransposable elements in ageing and age-associated diseases (2021) · cites this paper as [108]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Shelterin: the protein complex that shapes and safeguards human telomeres
de Lange, T. (2005) · Genes & Development · doi:10.1101/gad.1346005 · Cited by 3,056
RING Domain E3 Ubiquitin Ligases
Deshaies, R. J., & Joazeiro, C. A. P. (2009) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.78.101807.093809 · Cited by 2,679
Control of telomere length by the human telomeric protein TRF1
van Steensel, B., & de Lange, T. (1997) · Nature · doi:10.1038/385740a0 · Cited by 1,219
Meta-analysis of age-related gene expression profiles identifies common signatures of aging
de Magalhães, J. P., Curado, J., & Church, G. M. (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp073 · Cited by 737
Eusociality in a Mammal: Cooperative Breeding in Naked Mole-Rat Colonies
Jarvis, J. U. M. (1981) · Science · doi:10.1126/science.7209555 · Cited by 698
Buffenstein, R. (2008) · Journal of Comparative Physiology B · doi:10.1007/s00360-007-0237-5 · Cited by 487
Self-citationPérez, V. I., Buffenstein, R., Masamsetti, V., Leonard, S., Salmon, A. B., Mele, J., Andziak, B., Yang, T., Edrey, Y., Friguet, B., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0809620106 · Cited by 418
Self-citationAfrican mole-rats: ecology and eusociality
(2000) · Choice Reviews Online · doi:10.5860/choice.38-0940 · Cited by 397
Hypersensitivity to contact inhibition provides a clue to cancer resistance of naked mole-rat
Seluanov, A., Hine, C., Azpurua, J., Feigenson, M., Bozzella, M. J., Mao, Z., Catania, K. C., & Gorbunova, V. A. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0905252106 · Cited by 381
High oxidative damage levels in the longest‐living rodent, the naked mole‐rat
Andziak, B., O’Connor, T. P., Qi, W., deWaal, E., Pierce, A. P., Chaudhuri, A. R., Remmen, H. V., & Buffenstein, R. (2006) · Aging Cell · doi:10.1111/j.1474-9726.2006.00237.x · Cited by 351
Self-citation
Cited by
Sorted by citations
Items 101–200 of 577
Lu, J. Y., Simon, M. A., Zhao, Y., Ablaeva, J., Corson, N., Choi, Y., Yamada, K. Y. H., Schork, N. J., Hood, W. R., Hill, G. E., et al. (2022) · Cell Metabolism · doi:10.1016/j.cmet.2022.04.011 · Cited by 82
Rapamycin extends life- and health span because it slows aging
Blagosklonny, M. V. (2013) · Aging · doi:10.18632/aging.100591 · Cited by 82
Contrasting Gene Decay in Subterranean Vertebrates: Insights from Cavefishes and Fossorial Mammals
Policarpo, M., Fumey, J., Lafargeas, P., Naquin, D., Thermes, C., Naville, M., Dechaud, C., Volff, J., Cabau, C., Klopp, C., et al. (2020) · Molecular Biology and Evolution · doi:10.1093/molbev/msaa249 · Cited by 82
Seim, I., Ma, S., Zhou, X., Gerashchenko, M. V., Lee, S., SUYDAM, R. S., George, J. C., Bickham, J. W., & Gladyshev, V. N. (2014) · Aging · doi:10.18632/aging.100699 · Cited by 85
Self-citationŠumbera, R. (2018) · Journal of Thermal Biology · doi:10.1016/j.jtherbio.2018.11.003 · Cited by 80
Lidzbarsky, G. A., Gutman, D., Shekhidem, H. A., Sharvit, L. E., & Atzmon, G. (2018) · Frontiers in Medicine · doi:10.3389/fmed.2018.00104 · Cited by 85
Keane, M. P., Craig, T., Alföldi, J., Berlin, A. M., Johnson, J., Seluanov, A., Gorbunova, V. A., Palma, F. D., Lindblad‐Toh, K., Church, G. M., et al. (2014) · Bioinformatics · doi:10.1093/bioinformatics/btu579 · Cited by 77
Adaptation to Extreme Antarctic Environments Revealed by the Genome of a Sea Ice Green Alga
Zhang, Z., Qu, C., Zhang, K., He, Y., Zhao, X., Yang, L., Zheng, Z., Ma, X., Wang, X., Wang, W., et al. (2020) · Current Biology · doi:10.1016/j.cub.2020.06.029 · Cited by 79
Self-citationHayakawa, T., Suzuki–Hashido, N., Matsui, A., & Go, Y. (2014) · Molecular Biology and Evolution · doi:10.1093/molbev/msu144 · Cited by 77
Triplett, J. C., Tramutola, A., Swomley, A. M., Kirk, J. M., Grimes, K. M., Hardell, K. N. L., Orr, M. E., Rodriguez, K. A., Cai, J., Klein, J. B., et al. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2015.08.002 · Cited by 73
Self-citationNaked mole rat cells display more efficient excision repair than mouse cells
Evdokimov, A. N., Kutuzov, M. M., Petruseva, I. O., Lukjanchikova, N., Kashina, E. V., Kolova, E., Zemerova, T., Romanenko, S. A., Perelman, P. L., Prokopov, D., et al. (2018) · Aging · doi:10.18632/aging.101482 · Cited by 73
Hypofunctional TrkA Accounts for the Absence of Pain Sensitization in the African Naked Mole-Rat
Omerbašić, D., Smith, E. S. J., Moroni, M., Homfeld, J., Eigenbrod, O., Bennett, N. C., Reznick, J., Faulkes, C. G., Selbach, M., & Lewin, G. R. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.09.035 · Cited by 72
Prudent, X., Parra, G., Schwede, P., Roscito, J. G., & Hiller, M. (2016) · Molecular Biology and Evolution · doi:10.1093/molbev/msw098 · Cited by 71
Genetic adaptations of the plateau zokor in high-elevation burrows
Shao, Y., Li, J., Ge, R., Li, Z., Irwin, D. M., Murphy, R. W., & Zhang, Y. (2015) · Scientific Reports · doi:10.1038/srep17262 · Cited by 71
Sokolova, I. M., Sokolov, E. P., & Haider, F. (2019) · Integrative and Comparative Biology · doi:10.1093/icb/icz047 · Cited by 73
Turning the Oxygen Dial: Balancing the Highs and Lows
Baik, A. H., & Jain, I. H. (2020) · Trends in Cell Biology · doi:10.1016/j.tcb.2020.04.005 · Cited by 70
Mitochondria: a multimodal hub of hypoxia tolerance
Pamenter, M. E. (2014) · Canadian Journal of Zoology · doi:10.1139/cjz-2013-0247 · Cited by 69
The Intersection of Aging Biology and the Pathobiology of Lung Diseases: A Joint NHLBI/NIA Workshop
Budinger, G. R. S., Kohanski, R. A., Gan, W., Kobor, M. S., Amaral, L. A. N., Armanios, M. Y., Kelsey, K. T., Pardo, A., Tuder, R. M., Macián, F., et al. (2017) · The Journals of Gerontology Series A · doi:10.1093/gerona/glx090 · Cited by 69
Blunted Neuronal Calcium Response to Hypoxia in Naked Mole-Rat Hippocampus
Peterson, B. L., Larson, J., Buffenstein, R., Park, T. J., & Fall, C. P. (2012) · PLoS ONE · doi:10.1371/journal.pone.0031568 · Cited by 68
Self-citationComparative analysis of genome maintenance genes in naked mole rat, mouse, and human
MacRae, S. L., Zhang, Q., Lemetre, C., Seim, I., Calder, R. B., Hoeijmakers, J. H. J., Suh, Y., Gladyshev, V. N., Seluanov, A., Gorbunova, V. A., et al. (2015) · Aging Cell · doi:10.1111/acel.12314 · Cited by 68
Self-citationMa, S., Lee, S., Kim, E. B., Park, T. J., Seluanov, A., Gorbunova, V. A., Buffenstein, R., Seravalli, J., & Gladyshev, V. N. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.10.014 · Cited by 69
Self-citationSpecies comparison of liver proteomes reveals links to naked mole-rat longevity and human aging
Heinze, I., Bens, M., Calzia, E., Holtze, S., Dakhovnik, O., Sahm, A., Kirkpatrick, J. M., Szafranski, K., Romanov, N., Sama, S. N., et al. (2018) · BMC Biology · doi:10.1186/s12915-018-0547-y · Cited by 65
Local diffusion in the extracellular space of the brain
Tønnesen, J., Hrabětová, S., & Soria, F. N. (2022) · Neurobiology of Disease · doi:10.1016/j.nbd.2022.105981 · Cited by 66
Zhang, C., Cao, S., Toole, B. P., & Xu, Y. (2014) · International Journal of Cancer · doi:10.1002/ijc.28975 · Cited by 63
Davies, K. T. J., Bennett, N. C., Tsagkogeorga, G., Rossiter, S. J., & Faulkes, C. G. (2015) · Molecular Biology and Evolution · doi:10.1093/molbev/msv175 · Cited by 65
Aging, Metabolism, and Cancer Development: from Peto’s Paradox to the Warburg Effect
Tidwell, T., Søreide, K., & Hagland, H. R. (2017) · Aging and Disease · doi:10.14336/ad.2017.0713 · Cited by 64
Circadian regulation of cancer stem cells and the tumor microenvironment during metastasis
Wang, Y., Narasimamurthy, R., Qu, M., Shi, N., Guo, H.-D., Xue, Y., & Barker, N. (2024) · Nature Cancer · doi:10.1038/s43018-024-00759-4 · Cited by 62
Rapid molecular evolution across amniotes of the IIS/TOR network
McGaugh, S. E., Bronikowski, A. M., Kuo, C., Reding, D. M., Addis, E. A., Flagel, L., Janzen, F. J., & Schwartz, T. S. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1419659112 · Cited by 65
Oliver, K. R., & Greene, W. K. (2012) · Ecology and Evolution · doi:10.1002/ece3.400 · Cited by 62
Evolutionary Genetics of the Cavefish Astyanax mexicanus
Casañe, D., & Rétaux, S. (2016) · Advances in genetics · doi:10.1016/bs.adgen.2016.03.001 · Cited by 62
Long-lived rodents reveal signatures of positive selection in genes associated with lifespan
Sahm, A., Bens, M., Szafranski, K., Holtze, S., Groth, M., Görlach, M., Calkhoven, C. F., Müller, C., Schwab, M. G., Kraus, J. M., et al. (2018) · PLoS Genetics · doi:10.1371/journal.pgen.1007272 · Cited by 65
Li, Y., & de Magalhães, J. P. (2011) · AGE · doi:10.1007/s11357-011-9361-y · Cited by 61
Rodriguez, K. A., Osmulski, P. A., Pierce, A. P., Weintraub, S. T., Gaczynska, M. E., & Buffenstein, R. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2014.07.005 · Cited by 60
Self-citationChen, L., Tang, L., Xiang, H., Jin, L., Li, Q., Dong, Y., Wang, W., & Zhang, G. (2014) · GigaScience · doi:10.1186/2047-217x-3-24 · Cited by 62
Self-citationProtracted brain development in a rodent model of extreme longevity
Penz, O. K., Fuzik, J., Kurek, A. B., Romanov, R. A., Larson, J., Park, T. J., Harkany, T., & Keimpema, E. (2015) · Scientific Reports · doi:10.1038/srep11592 · Cited by 61
Self-citationHuang, Z., Jebb, D., & Teeling, E. C. (2016) · BMC Genomics · doi:10.1186/s12864-016-3227-8 · Cited by 61
Self-citationThe Naked Mole-Rat as a Model for Healthy Aging
Oka, K., Yamakawa, M., Kawamura, Y., Kutsukake, N., & Miura, K. (2022) · Annual Review of Animal Biosciences · doi:10.1146/annurev-animal-050322-074744 · Cited by 59
Zhavoronkov, A. A., Buzdin, A. A., Garazha, A., Borisov, N., & Moskalev, A. (2014) · Frontiers in Genetics · doi:10.3389/fgene.2014.00049 · Cited by 56
The companion dog as a unique translational model for aging
Mazzatenta, A., Carluccio, A., Robbe, D., Giulio, C. D., & Cellerino, A. (2017) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2017.08.024 · Cited by 59
Orr, M. E., Garbarino, V. R., Salinas, A., & Buffenstein, R. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00504 · Cited by 58
Self-citationNegligible senescence in naked mole rats may be a consequence of well-maintained splicing regulation
Lee, B. P., Smith, M., Buffenstein, R., & Harries, L. W. (2020) · GeroScience · doi:10.1007/s11357-019-00150-7 · Cited by 61
Self-citationSurprisingly long survival of premature conclusions about naked mole‐rat biology
Braude, S. H., Holtze, S., Begall, S., Brenmoehl, J., Burda, H., Dammann, P., del Marmol, D., Gorshkova, E. A., Henning, Y., Hoeflich, A., et al. (2020) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/brv.12660 · Cited by 57
The naked mole-rat as an animal model in biomedical research: current perspectives
Smith, E. S. J., Schuhmacher, L.-N., & Husson, Z. (2015) · Open Access Animal Physiology · doi:10.2147/oaap.s50376 · Cited by 26
Evolution of cancer suppression as revealed by mammalian comparative genomics
Tollis, M., Schiffman, J. D., & Boddy, A. M. (2017) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2016.12.004 · Cited by 58
A Limited Habitable Zone for Complex Life
Schwieterman, E. W., Reinhard, C. T., Olson, S. L., Harman, C. E., & Lyons, T. W. (2019) · The Astrophysical Journal · doi:10.3847/1538-4357/ab1d52 · Cited by 62
Marcovitz, A., Turakhia, Y., Chen, H. I., Gloudemans, M. J., Braun, B. A., Wang, H., & Bejerano, G. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1818532116 · Cited by 60
Adaptations to a hypoxic lifestyle in naked mole-rats
Pamenter, M. E. (2022) · Journal of Experimental Biology · doi:10.1242/jeb.196725 · Cited by 57
Evolutionary Constraint on Visual and Nonvisual Mammalian Opsins
Upton, B. A., Díaz, N. M., Gordon, S. A., Gelder, R. N. V., Buhr, E. D., & Lang, R. A. (2021) · Journal of Biological Rhythms · doi:10.1177/0748730421999870 · Cited by 54
Construction of Pseudomolecules for the Chinese Chestnut (Castanea mollissima) Genome
Wang, J., Tian, S., Sun, X., Cheng, X.-C., Duan, N., Tao, J., & GuangNing, S. (2020) · G3 Genes Genomes Genetics · doi:10.1534/g3.120.401532 · Cited by 52
Self-citationUnraveling the message: insights into comparative genomics of the naked mole-rat
Lewis, K. N., Soifer, I., Melamud, E., Roy, M. A., McIsaac, R. S., Hibbs, M., & Buffenstein, R. (2016) · Mammalian Genome · doi:10.1007/s00335-016-9648-5 · Cited by 53
Self-citationKaplinski, L., Lepamets, M., & Remm, M. (2015) · GigaScience · doi:10.1186/s13742-015-0097-y · Cited by 56
Li, C.-X., Zhao, S., Zhang, T., Xian, L., Liao, L., Liu, J., & Feng, J. (2017) · Scientific Reports · doi:10.1038/s41598-017-00567-0 · Cited by 50
HIF-1α contributes to hypoxia adaptation of the naked mole rat
Xiao, B., Wang, S., Yang, G., Sun, X., Zhao, S., Lin, L., Cheng, J., Yang, W., Cong, W., Sun, W., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.22767 · Cited by 52
Self-citationLv, H., Wang, Y., Han, F., Ji, J., Fang, Z., Zhuang, M., Li, Z., Zhang, Y., & Yang, L. (2020) · Scientific Reports · doi:10.1038/s41598-020-69389-x · Cited by 50
Self-citationBuffenstein, R., & Craft, W. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-65943-1_8 · Cited by 52
Self-citationPyott, S. J., van Tuinen, M., Screven, L. A., Schrode, K. M., Bai, J.-P., Barone, C. M., Price, S. D., Lysakowski, A., Sanderford, M. D., Kumar, S., et al. (2020) · Current Biology · doi:10.1016/j.cub.2020.08.035 · Cited by 48
Self-citationWang, B., Ekblom, R., Bunikis, I., Siitari, H., & Höglund, . (2014) · BMC Genomics · doi:10.1186/1471-2164-15-180 · Cited by 48
Self-citationSahu, S., Dattani, A., & Aboobaker, A. A. (2017) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2017.08.028 · Cited by 52
Ageing and sociality: why, when and how does sociality change ageing patterns?
Korb, J., & Heınze, J. (2021) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2019.0727 · Cited by 48
Epigenetic aging of the demographically non-aging naked mole-rat
Kerepesi, C., Meer, M. V., Ablaeva, J., Amoroso, V. G., Lee, S., Zhang, B., Gerashchenko, M. V., Trapp, A., Yim, S. H., Lu, A. T.-H., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-27959-9 · Cited by 53
Self-citationAdult neurogenesis and its anatomical context in the hippocampus of three mole-rat species
Amrein, I., Becker, A. S., Engler, S., Huang, S., ller, J. M. ⁄., Slomianka, L., & Oosthuizen, M. K. (2014) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2014.00039 · Cited by 46
Riera, C. E., & Dillin, A. G. (2015) · Nature Medicine · doi:10.1038/nm.4005 · Cited by 48
Exposure to cocaine and its main metabolites altered the protein profile of zebrafish embryos
Parolini, M., Bini, L., Magni, S., Rizzo, A., Ghilardi, A., Landi, C., Armini, A., Giacco, L. D., & Binelli, A. (2017) · Environmental Pollution · doi:10.1016/j.envpol.2017.09.097 · Cited by 46
The use of non-traditional models in the study of cancer resistance—the case of the naked mole rat
Shepard, A., & Kissil, J. L. (2020) · Oncogene · doi:10.1038/s41388-020-1355-8 · Cited by 48
Genome survey sequencing of red swamp crayfish Procambarus clarkii
Shi, L., Yi, S., & Li, Y. (2018) · Molecular Biology Reports · doi:10.1007/s11033-018-4219-3 · Cited by 46
Transformation of naked mole-rat cells
Hadi, F., Kulaberoglu, Y., Lazarus, K. A., Bach, K., Ugur, R., Beattie, P., Smith, E. S. J., & Khaled, W. T. (2020) · Nature · doi:10.1038/s41586-020-2410-x · Cited by 47
Stress, adaptation, and speciation in the evolution of the blind mole rat, Spalax, in Israel
Nevo, E. (2012) · Molecular Phylogenetics and Evolution · doi:10.1016/j.ympev.2012.09.008 · Cited by 44
Li, B., & Kimmel, M. (2013) · Genetics · doi:10.1534/genetics.113.154161 · Cited by 44
Grimes, K. M., Lindsey, M. L., Gelfond, J., & Buffenstein, R. (2012) · The Journals of Gerontology Series A · doi:10.1093/gerona/glr222 · Cited by 47
Self-citationTowards an integrated approach to understand Mexican cavefish evolution
Torres‐Paz, J., Hyacinthe, C., Pierre, C., & Rétaux, S. (2018) · Biology Letters · doi:10.1098/rsbl.2018.0101 · Cited by 44
Skulachev, M. V., & Skulachev, V. P. (2017) · Biochemistry (Moscow) · doi:10.1134/s000629791712001x · Cited by 43
As Blind as a Bat? Opsin Phylogenetics Illuminates the Evolution of Color Vision in Bats
Simões, B. F., Foley, N. M., Hughes, G. M., Zhao, H., Zhang, S., Rossiter, S. J., & Teeling, E. C. (2018) · Molecular Biology and Evolution · doi:10.1093/molbev/msy192 · Cited by 43
Hinaux, H., Blin, M., Fumey, J., Legendre, L., Heuzé, A., Casañe, D., & Rétaux, S. (2014) · Developmental Neurobiology · doi:10.1002/dneu.22239 · Cited by 41
Malik, A., Korol, A. B., Weber, M., Hankeln, T., Avivi, A., & Band, M. (2012) · BMC Genomics · doi:10.1186/1471-2164-13-615 · Cited by 41
Emerling, C. A. (2017) · Molecular Phylogenetics and Evolution · doi:10.1016/j.ympev.2017.07.014 · Cited by 40
Ortiz‐Prado, E., Espinosa, P. S., Borrero, A., Cordovez, S., Vásconez-González, J., Barreto-Grimaldos, A., Coral-Almeida, M., Henriquez-Trujillo, A. R., Simbaña‐Rivera, K., Gómez‐Barreno, L., et al. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.733928 · Cited by 41
Lewis, K. N., & Buffenstein, R. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-411596-5.00006-x · Cited by 42
Self-citationProbing Pedomorphy and Prolonged Lifespan in Naked Mole-Rats and Dwarf Mice
Buffenstein, R., Lewis, K. N., Gibney, P. A., Narayan, V., Grimes, K. M., Smith, M., Lin, T., & Brown‐Borg, H. M. (2020) · Physiology · doi:10.1152/physiol.00032.2019 · Cited by 39
Self-citationFaulkes, C. G., Eykyn, T. R., Miljković, J. L., Gilbert, J. D., Charles, R. L., Prag, H. A., Patel, N., Hart, D. W., Murphy, M. P., Bennett, N. C., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-46470-x · Cited by 39
Naked Mole Rat Induced Pluripotent Stem Cells and Their Contribution to Interspecific Chimera
Lee, S., Mikhalchenko, A. E., Yim, S. H., Lobanov, A. V., Park, J., Choi, K., Bronson, R. T., Lee, C.-K., Park, T. J., & Gladyshev, V. N. (2017) · Stem Cell Reports · doi:10.1016/j.stemcr.2017.09.013 · Cited by 38
Self-citationDomankevich, V., Eddini, H., Odeh, A., & Shams, I. (2018) · Journal of Experimental Biology · doi:10.1242/jeb.174540 · Cited by 37
Advancing human disease research with fish evolutionary mutant models
Beck, E. A., Healey, H. M., Small, C. M., Currey, M. C., Desvignes, T., Cresko, W. A., & Postlethwait, J. H. (2021) · Trends in Genetics · doi:10.1016/j.tig.2021.07.002 · Cited by 38
Comparative Analysis of Mammal Genomes Unveils Key Genomic Variability for Human Life Span
Farré, X., Molina-Fernández, R., Barteri, F., Timmers, P. R. H. J., Joshi, P. K., Oliva, B., Acosta, S., Esteve‐Altava, B., Navarro, A., & Muntané, G. (2021) · Molecular Biology and Evolution · doi:10.1093/molbev/msab219 · Cited by 38
Learning of nature: The curious case of the naked mole rat
Lagunas‐Rangel, F. A., & Chávez‐Valencia, V. (2017) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2017.04.010 · Cited by 37
Hypoxia potentially promotes Tibetan longevity
Li, Y., Wang, M., Otecko, N. O., Wang, W., Shi, P., Wu, D., & Zhang, Y. (2016) · Cell Research · doi:10.1038/cr.2016.105 · Cited by 36
Ma, L., Gore, A. V., Castranova, D., Shi, J., Ng, M., Tomins, K. A., van der Weele, C. M., Weinstein, B. M., & Jeffery, W. R. (2020) · Nature Communications · doi:10.1038/s41467-020-16497-x · Cited by 36
Social Evolution in African Mole-Rats – A Comparative Overview
Faulkes, C. G., & Bennett, N. C. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-65943-1_1 · Cited by 39
Zhou, S., Holmes, M. M., Forger, N. G., Goldman, B. D., Lovern, M. B., Caraty, A., Kalló, I., Faulkes, C. G., & Coen, C. W. (2013) · The Journal of Comparative Neurology · doi:10.1002/cne.23327 · Cited by 36
Slow aging in mammals—Lessons from African mole-rats and bats
Dammann, P. (2017) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2017.07.006 · Cited by 35
Nest Carbon Dioxide Masks GABA-Dependent Seizure Susceptibility in the Naked Mole-Rat
Zions, M., Meehan, E. F., Kress, M., Thevalingam, D., Jenkins, E. C., Kaila, K., Puskarjov, M., & McCloskey, D. P. (2020) · Current Biology · doi:10.1016/j.cub.2020.03.071 · Cited by 37
Ingram, C. M., Troendle, N. J., Gill, C. A., Braude, S. H., & Honeycutt, R. L. (2015) · Molecular Ecology · doi:10.1111/mec.13358 · Cited by 35
Herrera‐Álvarez, S., Karlsson, E. K., Ryder, O. A., Lindblad‐Toh, K., & Crawford, A. J. (2020) · Molecular Biology and Evolution · doi:10.1093/molbev/msaa285 · Cited by 36
Transcriptomic Insights into the Loss of Vision in Molnár János Cave’s Crustaceans
Pérez‐Moreno, J. L., Balázs, G., & Bracken‐Grissom, H. D. (2018) · Integrative and Comparative Biology · doi:10.1093/icb/icy071 · Cited by 34
Evolutionary Genetics of Hypoxia and Cold Tolerance in Mammals
Zhu, K., Ge, D., Wen, Z., Xia, L., & Yang, Q. (2018) · Journal of Molecular Evolution · doi:10.1007/s00239-018-9870-8 · Cited by 35
The Singularity of Cetacea Behavior Parallels the Complete Inactivation of Melatonin Gene Modules
Lopes‐Marques, M., Ruivo, R., Alves, L. Q., Sousa, N., Machado, A. M., & Castro, L. F. C. (2019) · Genes · doi:10.3390/genes10020121 · Cited by 34
Bens, M., Szafranski, K., Holtze, S., Sahm, A., Groth, M., Kestler, H. A., Hildebrandt, T. B., & Platzer, M. (2018) · BMC Biology · doi:10.1186/s12915-018-0546-z · Cited by 34
Hadj‐Moussa, H., Pamenter, M. E., & Storey, K. B. (2020) · Journal of Cellular Physiology · doi:10.1002/jcp.30216 · Cited by 36
Lifespan Extension in Long-Lived Vertebrates Rooted in Ecological Adaptation
Omotoso, O., Gladyshev, V. N., & Zhou, X. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.704966 · Cited by 35
Self-citationOrr, M. E., Garbarino, V. R., Salinas, A., & Buffenstein, R. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.12.004 · Cited by 34
Self-citationNdhlovu, L. C., Bendall, M. L., Dwaraka, V. B., Pang, A. P. S., Dopkins, N., Carreras-Gallo, N., Smith, R. C., Nixon, D. F., & Corley, M. J. (2024) · Aging Cell · doi:10.1111/acel.14288 · Cited by 38
Metadata
- Authors
- Kim, E. B., Fang, X., Fushan, A. A., Huang, Z., Lobanov, A. V., Han, L., Marino, S. M., Sun, X., Turanov, A. A., Yang, P., Yim, S. H., Zhao, X., Kasaikina, M. V., Stoletzki, N., Peng, C., Polak, P., Xiong, Z., Kiezun, A., Zhu, Y., Chen, Y., Kryukov, G. V., Zhang, Q., Peshkin, L., Yang, L., Bronson, R. T., Buffenstein, R., Wang, B., Han, C., Li, Q., Chen, L., Zhao, W., Sunyaev, S. R., Park, T. J., Zhang, G., Wang, J., & Gladyshev, V. N.
- Affiliations
- Ewha Womans University (KR)
- BGI Group (China) (CN)
- Brigham and Women's Hospital (US)
- Broad Institute (US)
- Harvard University (US)
- The University of Texas at San Antonio Health Science Center (US)
- University of Illinois Chicago (US)
- Corresponding author
- Zhang, Guojie
- Wang, Jun
- Gladyshev, Vadim N.
- ORCID
- Kim, Eun Bae
- Fang, Xiaodong
- Huang, Zhiyong
- Lobanov, Alexei V.
- Han, Lijuan
- Marino, Stefano M.
- Sun, Xiaoqing
- Yang, Pengcheng
- Yim, Sun Hee
- Zhao, Xiang
- Stoletzki, Nina
- Polak, Paz
- Xiong, Zhiqiang
- Zhu, Yabing
- Chen, Yuanxin
- Kryukov, Gregory V.
- Peshkin, Leonid
- Bronson, Roderick T.
- Buffenstein, Rochelle
- Wang, Bo
- Li, Qiye
- Chen, Li
- Zhao, Wei
- Sunyaev, Shamil R.
- Park, Thomas J.
- Zhang, Guojie
- Wang, Jun
- Gladyshev, Vadim N.
- Venue
- Nature
- Published
- 2011-10-12
- Volume
- 479
- Issue
- 7372
- Pages
- 223-227
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC3319411
- OpenAlex
- W2026944808
- Semantic Scholar
- f13611166eb11cefa0156fe963647ed6e0952741
- Cited by
- 576
- References
- 30
- Citations by year
- 2026: 17 · 2025: 18 · 2024: 23 · 2023: 34 · 2022: 41 · 2021: 50 · 2020: 71 · 2019: 31 · 2018: 41 · 2017: 34 · 2016: 41 · 2015: 56 · 2014: 43 · 2013: 44 · 2012: 30
- FWCI
- 13.43
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Nature (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- National Science Foundation (0744979)
- National Natural Science Foundation of China (30725008)
- National Institutes of Health
- National Institute on Aging (R01AG038004, R01AG021518)
- National Cancer Institute (R01CA080946)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Chromosomal and Genetic Variations
- Keywords
- naked mole-rat, genome sequence, tumor resistance, longevity, aging, low oxygen tolerance, poikilothermy, hairlessness, visual function, circadian rhythm, taste sensing, eusociality, genome stability, oxidative stress, ubiquitination, subterranean mammals
- MeSH terms
- Uncoupling Protein 1, Adaptation, Physiological, Aging, Amino Acid Sequence, Animals, Body Temperature Regulation, Carbon Dioxide, Circadian Rhythm, Darkness, Genes, Humans, Ion Channels, Longevity, Male, Molecular Sequence Data, Oxygen, Taste, Visual Perception, Mutagenesis, Genome, Mole Rats, Genomics, Mitochondrial Proteins, Genomic Instability, Transcriptome
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
