Cited by 3,162Cancer Genomics and DiagnosticsCancer Cells and MetastasisEvolution and Genetic Dynamics

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Clonal evolution in cancer

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Greaves, Mel, Maley, Carlo C.·2012·Nature

DOI 10.1038/nature10762PMC PMC3367003

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Abstract

Cancers evolve by a reiterative process of clonal expansion, genetic diversification and clonal selection within the adaptive landscapes of tissue ecosystems. The dynamics are complex, with highly variable patterns of genetic diversity and resulting clonal architecture. Therapeutic intervention may destroy cancer clones and erode their habitats, but it can also inadvertently provide a potent selective pressure for the expansion of resistant variants. The inherently Darwinian character of cancer is the primary reason for this therapeutic failure, but it may also hold the key to more effective control.

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Self-citation

Authors: Greaves, M., & Maley, C. C.
Affiliations: University of California, San Francisco (US)
ORCID: Maley, Carlo C.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2012-01
Volume: 481
Issue: 7381
Pages: 306-313
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature10762
PMC: PMC3367003
OpenAlex: W2023560061
Cited by: 3,162
References: 104
Citations by year: 2026: 180 · 2025: 160 · 2024: 181 · 2023: 225 · 2022: 204 · 2021: 253 · 2020: 229 · 2019: 211 · 2018: 247 · 2017: 296 · 2016: 247 · 2015: 238 · 2014: 221 · 2013: 164 · 2012: 101
FWCI: 17.27
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Funders: National Cancer Institute (R01CA149566, P01CA091955, U54CA143803, P01CA91955, R01CA140657)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer Genomics and Diagnostics
Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
Keywords: clonal evolution, cancer, clonal expansion, genetic diversification, clonal selection, fitness landscape, tumor microenvironment, clonal architecture, drug resistance
MeSH terms: Animals, Clone Cells, Humans, Mutation, Neoplasms, Neoplastic Stem Cells, Genomics, Tumor Microenvironment, Clonal Evolution

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