Cited by 3,162Cancer Genomics and DiagnosticsCancer Cells and MetastasisEvolution and Genetic Dynamics

The DOI matches its Crossref record; 104 of the 107 references it cites were found in a registry or an index, and 3 are not checked yet.

Clonal evolution in cancer

Open access

Greaves, Mel, Maley, Carlo C.·2012·Nature

DOI 10.1038/nature10762PMC PMC3367003

Open this paper in CoChat — free account

Abstract

Cancers evolve by a reiterative process of clonal expansion, genetic diversification and clonal selection within the adaptive landscapes of tissue ecosystems. The dynamics are complex, with highly variable patterns of genetic diversity and resulting clonal architecture. Therapeutic intervention may destroy cancer clones and erode their habitats, but it can also inadvertently provide a potent selective pressure for the expansion of resistant variants. The inherently Darwinian character of cancer is the primary reason for this therapeutic failure, but it may also hold the key to more effective control.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1038/nature10762

Cites

104 of 107 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Hallmarks of Cancer: The Next Generation
Hanahan, D., & Weinberg, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.02.013 · Cited by 66,590
Cancer Statistics, 2008
Jemal, A., Siegel, R. L., Ward, E., Hao, Y., Xu, J., Murray, T., & Thun, M. J. (2008) · CA A Cancer Journal for Clinicians · doi:10.3322/ca.2007.0010 · Cited by 10,184
Stem cells, cancer, and cancer stem cells
Reya, T., Morrison, S. J., Clarke, M. F., & Weissman, I. L. (2001) · Nature · doi:10.1038/35102167 · Cited by 9,738
The Clonal Evolution of Tumor Cell Populations: Acquired genetic lability permits stepwise selection of variant sublines and underlies tumor progression.
Nowell, P. C. (1976) · Science · doi:10.1126/science.959840 · Cited by 6,471
A Chromatin-Mediated Reversible Drug-Tolerant State in Cancer Cell Subpopulations
Sharma, S. V., Lee, D. Y., Li, B., Quinlan, M. P., Takahashi, F., Maheswaran, S., McDermott, U., Azizian, N., Zou, L., Fischbach, M. A., et al. (2010) · Cell · doi:10.1016/j.cell.2010.02.027 · Cited by 2,770
Tumour evolution inferred by single-cell sequencing
Navin, N., Kendall, J., Troge, J., Andrews, P., Rodgers, L., McIndoo, J., Cook, K., Stepansky, A., Levy, D., Esposito, D., et al. (2011) · Nature · doi:10.1038/nature09807 · Cited by 2,598
Distant metastasis occurs late during the genetic evolution of pancreatic cancer
Yachida, S., Jones, S., Bozic, I., Antal, T., Leary, R., Fu, B., Kamiyama, M., Hruban, R. H., Eshleman, J. R., Nowak, M. A., et al. (2010) · Nature · doi:10.1038/nature09515 · Cited by 2,502
Identification of Selective Inhibitors of Cancer Stem Cells by High-Throughput Screening
Gupta, P. B., Önder, T. T., Jiang, G., Tao, K. X., Kuperwasser, C., Weinberg, R. A., & Lander, E. S. (2009) · Cell · doi:10.1016/j.cell.2009.06.034 · Cited by 2,429
Massive genomic rearrangement acquired in a single catastrophic event during cancer development
Stephens, P. J., Greenman, C. D., Fu, B., Yang, F., Bignell, G. R., Mudie, L. J., Pleasance, E. D., Lau, K. W., Beare, D., Stebbings, L. A., et al. (2011) · Cell · doi:10.1016/j.cell.2010.11.055 · Cited by 2,414
A Perivascular Niche for Brain Tumor Stem Cells
Calabrese, C. R., Poppleton, H., Koçak, M., Hogg, T. L., Fuller, C. E., Hamner, J. B., Oh, E. Y., Gaber, M. W., Finklestein, D., Allen, M., et al. (2007) · Cancer Cell · doi:10.1016/j.ccr.2006.11.020 · Cited by 2,253

Show all 104 references

Sorted by citations

Items 501–600 of 1,004

Evolutionary mechanism unifies the hallmarks of cancer
Horne, S. D., Pollick, S. A., & Heng, H. H. (2014) · International Journal of Cancer · doi:10.1002/ijc.29031 · Cited by 90
A framework for how environment contributes to cancer risk
Hochberg, M., & Noble, R. (2017) · Ecology Letters · doi:10.1111/ele.12726 · Cited by 86
NOTCH3 expression is linked to breast cancer seeding and distant metastasis
Leontovich, A. A., Jalalirad, M., Salisbury, J. L., Mills, L., Haddox, C. L., Schroeder, M. A., Tuma, A. C. M., Guicciardi, M. E., Zammataro, L. A., Gambino, M. W., et al. (2018) · Breast Cancer Research · doi:10.1186/s13058-018-1020-0 · Cited by 82
Applying ecological and evolutionary theory to cancer: a long and winding road
Frédéric Thomas, A., Fisher, D., Fort, P., Marie, J., Daoust, S. P., Roche, B., Grunau, C., Cosseau, C., Mitta, G., Baghdiguian, S., et al. (2012) · Evolutionary Applications · doi:10.1111/eva.12021 · Cited by 85
Molecular profiling of long-term survivors identifies a subgroup of glioblastoma characterized by chromosome 19/20 co-gain
Geisenberger, C., Möck, A., Warta, R., Rapp, C., Schwager, C., Korshunov, A., Nied, A.-K., Capper, D., Brors, B., Jungk, C., et al. (2015) · Acta Neuropathologica · doi:10.1007/s00401-015-1427-y · Cited by 78
The Role of SVZ Stem Cells in Glioblastoma
Altmann, C., Keller, S., & Schmidt, M. H. H. (2019) · Cancers · doi:10.3390/cancers11040448 · Cited by 81
Stem Cells and Cellular Origins of Breast Cancer: Updates in the Rationale, Controversies, and Therapeutic Implications
Zhou, J., Chen, Q., Zou, Y., Chen, H., Qi, L., & Chen, Y. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.00820 · Cited by 84
Convergent Evolution, Evolving Evolvability, and the Origins of Lethal Cancer
Pienta, K. J., Hammarlund, E. U., Axelrod, R., Amend, S. R., & Brown, J. S. (2020) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-19-1158 · Cited by 84
Genomic alterations driving precancerous to cancerous lesions in esophageal cancer development
Chang, J., Zhao, X., Wang, Y., Liu, T., Zhong, C., Lao, Y., Zhang, S., Liao, H., Bai, F., Lin, D., et al. (2023) · Cancer Cell · doi:10.1016/j.ccell.2023.11.003 · Cited by 85
A general framework for analyzing tumor subclonality using SNP array and DNA sequencing data
Li, B., & Li, J. Z. (2014) · Genome biology · doi:10.1186/s13059-014-0473-4 · Cited by 76
Deep Sequencing in Conjunction with Expression and Functional Analyses Reveals Activation of FGFR1 in Ewing Sarcoma
Agelopoulos, K., Richter, G. H. S., Schmidt, E. M., Dirksen, U., von Heyking, K., Moser, B., Klein, H., Kontny, U., Dugas, M., Poos, K., et al. (2015) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-14-2744 · Cited by 81
SF3B1 mutant MDS-initiating cells may arise from the haematopoietic stem cell compartment
Mian, S. A., Rouault‐Pierre, K., Smith, A., Seidl, T., Pizzitola, I., Kizilors, A., Kulasekararaj, A. G., Bonnet, D. A., & Mufti, G. J. (2015) · Nature Communications · doi:10.1038/ncomms10004 · Cited by 87
Challenges of deciphering gastric cancer heterogeneity
Hudler, P. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i37.10510 · Cited by 80
Acquired resistance to KRAS G12C small-molecule inhibitors via genetic/nongenetic mechanisms in lung cancer
Mohanty, A., Nam, A., Srivastava, S., Jones, J., Lomenick, B., Singhal, S. S., Guo, L., Cho, H., Li, A., Behal, A., et al. (2023) · Science Advances · doi:10.1126/sciadv.ade3816 · Cited by 79
Rewired Metabolism in Drug-resistant Leukemia Cells
Stäubert, C., Bhuiyan, H., Lindahl, A., Broom, O. J., Zhu, Y., Islam, S., Linnarsson, S., Lehtiö, J., & Nordström, A. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.618769 · Cited by 79
Pancreatic tumor microenvironment confers highly malignant properties on pancreatic cancer cells
Takahashi, K., Ehata, S., Koinuma, D., Morishita, Y., Soda, M., Mano, H., & Miyazono, K. (2018) · Oncogene · doi:10.1038/s41388-018-0144-0 · Cited by 79
Changing paradigms in diagnosis and treatment of monoclonal gammopathy of undetermined significance (MGUS) and smoldering multiple myeloma (SMM)
Ho, M., Patel, A. S., Goh, C. Y., Moscvin, M., Zhang, L., & Bianchi, G. (2020) · Leukemia · doi:10.1038/s41375-020-01051-x · Cited by 83
Analysis and Interpretation of the Impact of Missense Variants in Cancer
Petrosino, M., Novak, L., Pasquo, A., Chiaraluce, R., Turina, P., Capriotti, E., & Consalvi, V. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22115416 · Cited by 81
Targeting cholangiocarcinoma
Mertens, J. C., Ilyas, S. I., & Gores, G. J. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2017.08.027 · Cited by 80
Liquid biopsy and non-small cell lung cancer: are we looking at the tip of the iceberg?
Bonanno, L., Maso, A. D., Pavan, A., Zulato, E., Calvetti, L., Pasello, G., Guarneri, V., Conte, P., & Indraccolo, S. (2022) · British Journal of Cancer · doi:10.1038/s41416-022-01777-8 · Cited by 81
T-LAK Cell-Originated Protein Kinase (TOPK) as a Prognostic Factor and a Potential Therapeutic Target in Ovarian Cancer
Ikeda, Y., Park, J.-H., Miyamoto, T., Takamatsu, N., Kato, T., Akiko, I., Okabe, S., Imai, Y., Fujiwara, K., Nakamura, Y., et al. (2016) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-16-0207 · Cited by 79
CRISPR-Barcoding for Intratumor Genetic Heterogeneity Modeling and Functional Analysis of Oncogenic Driver Mutations
Guernet, A. A., Mungamuri, S. K., Cartier, D., Sachidanandam, R., Jayaprakash, A. D., Adriouch, S., Vézain, M., Charbonnier, F., Rohkin, G., Coutant, S., et al. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.06.017 · Cited by 85
Chromosome instability drives phenotypic switching to metastasis
Gao, C., Su, Y., Koeman, J. M., Haak, E. A., Dykema, K. J., Essenberg, C., Hudson, E., Petillo, D., Khoo, S. K., & Woude, G. F. V. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1618215113 · Cited by 79
Molecular Oncology of Breast Cancer
Joshi, H. N., & Press, M. F. (2017) · Elsevier eBooks · doi:10.1016/b978-0-323-35955-9.00022-2 · Cited by 85
A Sixth Modality of Infectious Disease: Contagious Cancer from Devils to Clams and Beyond
Metzger, M. J., & Goff, S. P. (2016) · PLoS Pathogens · doi:10.1371/journal.ppat.1005904 · Cited by 78
Copy-number analysis and inference of subclonal populations in cancer genomes using Sclust
Cun, Y., Yang, T.-P., Achter, V., Lang, U., & Peifer, M. (2018) · Nature Protocols · doi:10.1038/nprot.2018.033 · Cited by 78
A systematic review of the validity of patient derived xenograft (PDX) models: the implications for translational research and personalised medicine
Collins, A. T., & Lang, S. (2018) · PeerJ · doi:10.7717/peerj.5981 · Cited by 76
Cancer cells employ an evolutionarily conserved polyploidization program to resist therapy
Pienta, K. J., Hammarlund, E. U., Austin, R. H., Axelrod, R., Brown, J. S., & Amend, S. R. (2020) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2020.11.016 · Cited by 80
Understanding Drug Sensitivity and Tackling Resistance in Cancer
Tyner, J. W., Haderk, F., Kumaraswamy, A., Baughn, L. B., Ness, B. V., Liu, S., Marathe, H., Alumkal, J. J., Bivona, T. G., Chan, K. S., et al. (2022) · Cancer Research · doi:10.1158/0008-5472.can-21-3695 · Cited by 81
Genomic heterogeneity as a barrier to precision oncology in urothelial cancer
Clinton, T. N., Chen, Z., Wise, H. C., Lenis, A. T., Chavan, S. S., Donoghue, M. T. A., Almassi, N., Chu, C. E., Dason, S., Rao, P., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111859 · Cited by 79
Peto's paradox and the promise of comparative oncology
Nunney, L., Maley, C. C., Breen, M., Hochberg, M., & Schiffman, J. D. (2015) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2014.0177 · Cited by 78
Self-citation
Reconstructing the molecular life history of gliomas
Barthel, F. P., Wesseling, P., & Verhaak, R. G. W. (2018) · Acta Neuropathologica · doi:10.1007/s00401-018-1842-y · Cited by 86
Glioblastoma cancer stem cells: Biomarker and therapeutic advances
Pointer, K. B., Clark, P. A., Zorniak, M., Alrfaei, B. M., & Kuo, J. S. (2014) · Neurochemistry International · doi:10.1016/j.neuint.2014.03.005 · Cited by 82
Simultaneous evolutionary expansion and constraint of genomic heterogeneity in multifocal lung cancer
Ma, P., Fu, Y., Cai, M., Yan, Y., Jing, Y., Zhang, S., Chen, M., Wu, J., Shen, Y., Zhu, L. W., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-00963-0 · Cited by 75
Chemical carcinogenicity revisited 1: A unified theory of carcinogenicity based on contemporary knowledge
Wolf, D. C., Cohen, S. M., Boobis, A. R., Dellarco, V. L., Fenner-Crisp, P. A., Moretto, A., Pastoor, T. P., Schoeny, R. S., Seed, J. G., & Doe, J. E. (2019) · Regulatory Toxicology and Pharmacology · doi:10.1016/j.yrtph.2019.01.021 · Cited by 77
Stem cells in tissues, organoids, and cancers
Wang, X. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03199-x · Cited by 80
Genomic evidence supports a clonal diaspora model for metastases of esophageal adenocarcinoma
Noorani, A., Li, X., Goddard, M. J., Crawte, J., Alexandrov, L. B., Secrier, M., Eldridge, M., Bower, L., Weaver, J. M. J., Lao-Sirieix, P., et al. (2020) · Nature Genetics · doi:10.1038/s41588-019-0551-3 · Cited by 75
Multifaceted role of chemokines in solid tumors: From biology to therapy
Raza, S., Rajak, S., Tewari, A., Gupta, P., Chattopadhyay, N., Sinha, R. A., & Chakravarti, B. (2022) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2021.12.011 · Cited by 79
Drug resistance in cancer: molecular evolution and compensatory proliferation
Friedman, R. (2016) · Oncotarget · doi:10.18632/oncotarget.7459 · Cited by 77
Tracking the evolution of cancer cell populations through the mathematical lens of phenotype-structured equations
Lorenzi, T., Chisholm, R. H., & Clairambault, J. (2016) · Biology Direct · doi:10.1186/s13062-016-0143-4 · Cited by 75
Inducing cancer indolence by targeting mitochondrial Complex I is potentiated by blocking macrophage-mediated adaptive responses
Kurelac, I., Iommarini, L., Vatrinet, R., Amato, L. B., Luise, M. D., Leone, G., Girolimetti, G., Ganesh, N. U., Bridgeman, V. L., Ombrato, L., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-08839-1 · Cited by 75
Animal Models of Chemical Carcinogenesis: Driving Breakthroughs in Cancer Research for 100 YearsPreprint
Kemp, C. J. (2015) · Cold Spring Harbor Protocols · doi:10.1101/pdb.top069906 · Cited by 85
HIT'nDRIVE: patient-specific multidriver gene prioritization for precision oncologyPreprint
Shrestha, R., Hodzic, E., Sauerwald, T., Dao, P., Wang, K., Yeung, J., Anderson, S. A., Vandin, F., Haffari, G., Collins, C. C., et al. (2017) · Genome Research · doi:10.1101/gr.221218.117 · Cited by 77
Intratumoral Molecular Heterogeneity in a BRAF-Mutant, BRAF Inhibitor-Resistant Melanoma: A Case Illustrating the Challenges for Personalized Medicine
Wilmott, J. S., Tembe, V., Howle, J. R., Sharma, R. N., Thompson, J. F., Rizos, H., Lo, R. S., Kefford, R. F., Scolyer, R. A., & Long, G. V. (2012) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-12-0530 · Cited by 76
Switching off CD73: a way to boost the activity of conventional and targeted antineoplastic therapies
Antonioli, L., Novitskiy, S. V., Sachsenmeier, K. F., Fornai, M., Blandizzi, C., & Haskó, G. (2017) · Drug Discovery Today · doi:10.1016/j.drudis.2017.06.005 · Cited by 77
Capitalizing on competition: An evolutionary model of competitive release in metastatic castration resistant prostate cancer treatment
West, J., Ma, Y., & Newton, P. K. (2018) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2018.07.028 · Cited by 76
Multiple Myeloma: Molecular Pathogenesis and Disease Evolution
Heider, M., Nickel, K., Högner, M., & Bassermann, F. C. (2021) · Oncology Research and Treatment · doi:10.1159/000520312 · Cited by 85
Polyploid giant cancer cells and cancer progression
Zhou, X., Zhou, M., Zheng, M., Tian, S., Yang, X., Ning, Y., Li, Y., & Zhang, S. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.1017588 · Cited by 81
Genetic and Functional Diversity of Propagating Cells in Glioblastoma
Piccirillo, S. G. M., Colman, S., Potter, N. E., van Delft, F. W., Lillis, S., Carnicer, M.-J., Kearney, L., Watts, C., & Greaves, M. F. (2014) · Stem Cell Reports · doi:10.1016/j.stemcr.2014.11.003 · Cited by 77
Self-citation
Cancer Metabolism: A Modeling Perspective
Ghaffari, P., Mardinoğlu, A., & Nielsen, J. (2015) · Frontiers in Physiology · doi:10.3389/fphys.2015.00382 · Cited by 76
Smart Drug Delivery System
Sezer, A. D. (2016) · InTech eBooks · doi:10.5772/60475 · Cited by 78
Polymerase-mediated ultramutagenesis in mice produces diverse cancers with high mutational load
Li, H., Cuevas, I., Zhang, M., Lu, C., Alam, M. M., Fu, Y., You, M., Akbay, E. A., Zhang, H., & Castrillón, D. H. (2018) · Journal of Clinical Investigation · doi:10.1172/jci122095 · Cited by 80
Deep Sequencing Reveals Occurrence of Subclonal ALK Mutations in Neuroblastoma at Diagnosis
Bellini, A., Bernard, V., Leroy, Q., Frio, T. R., Pierron, G., Combaret, V., Lapouble, E., Clément, N., Rubie, H., Thébaud, E., et al. (2015) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-15-0423 · Cited by 78
Asymptotic analysis and optimal control of an integro-differential system modelling healthy and cancer cells exposed to chemotherapy
Pouchol, C., Clairambault, J., Lorz, A., & Trélat, E. (2017) · Journal de Mathématiques Pures et Appliquées · doi:10.1016/j.matpur.2017.10.007 · Cited by 75
Epidermal Growth Factor Receptor: Key to Selective Intracellular Delivery
Rosenkranz, A. A., & Slastnikova, T. A. (2020) · Biochemistry (Moscow) · doi:10.1134/s0006297920090011 · Cited by 76
Integrative single-cell analysis of allele-specific copy number alterations and chromatin accessibility in cancer
Wu, C.-Y., Lau, B. T., Kim, H. S., Sathe, A., Grimes, S. M., Ji, H. P., & Zhang, N. R. (2021) · Nature Biotechnology · doi:10.1038/s41587-021-00911-w · Cited by 75
Mixed strain pathogen populations accelerate the evolution of antibiotic resistance in patients
Caballero, J. D., Wheatley, R. M., Kapel, N., López-Causapé, C., van der Schalk, T. E., Quinn, A., Shaw, L. P., Ogunlana, L., Recanatini, C., Xavier, B. B., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-39416-2 · Cited by 88
IgG subclass switching and clonal expansion in cutaneous melanoma and normal skin
Saul, L., Ilieva, K. M., Bax, H. J., Karagiannis, P., Corrêa, I., Rodríguez‐Hernández, I., Josephs, D. H., Tosi, I., Egbuniwe, I. U., Lombardi, S., et al. (2016) · Scientific Reports · doi:10.1038/srep29736 · Cited by 75
High expression of PD-1 ligands is associated with kataegis mutational signature and APOBEC3 alterations
Boichard, A., Tsigelny, I. F., & Kurzrock, R. (2017) · OncoImmunology · doi:10.1080/2162402x.2017.1284719 · Cited by 75
Metabolism in cancer metastasis: bioenergetics, biosynthesis, and beyond
Teoh, S. T., & Lunt, S. Y. (2017) · WIREs Systems Biology and Medicine · doi:10.1002/wsbm.1406 · Cited by 77
Contribution of pks+ E. coli mutations to colorectal carcinogenesis
Chen, B., Ramazzotti, D., Heide, T., Spiteri, I., Fernandez-Mateos, J., James, C., Magnani, L., Graham, T. A., & Sottoriva, A. (2023) · Nature Communications · doi:10.1038/s41467-023-43329-5 · Cited by 74
Novel Insights on Lipid Metabolism Alterations in Drug Resistance in Cancer
Yang, R., Yi, M., & Xiang, B. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.875318 · Cited by 80
Application of single-cell genomics in cancer: promise and challenges
Wills, Q. F., & Mead, A. J. (2015) · Human Molecular Genetics · doi:10.1093/hmg/ddv235 · Cited by 77
Advances for studying clonal evolution in cancer
Ding, L., Raphael, B. J., Chen, F., & Wendl, M. C. (2013) · Cancer Letters · doi:10.1016/j.canlet.2012.12.028 · Cited by 74
Measuring intratumor heterogeneity by network entropy using RNA-seq data
Park, Y., Lim, S., Nam, J., & Kim, S. (2016) · Scientific Reports · doi:10.1038/srep37767 · Cited by 77
One microenvironment does not fit all: heterogeneity beyond cancer cells
Kim, I. S., & Zhang, X. H.-F. (2016) · Cancer and Metastasis Reviews · doi:10.1007/s10555-016-9643-z · Cited by 75
The role of autophagy in the cross-talk between epithelial-mesenchymal transitioned tumor cells and cancer stem-like cells
Marcucci, F., Ghezzi, P., & Rumio, C. (2017) · Molecular Cancer · doi:10.1186/s12943-016-0573-8 · Cited by 76
High prevalence of focal and multi-focal somatic genetic variants in the human brain
Keogh, M. J., Wei, W., Aryaman, J., Walker, L., van den Ameele, J., Coxhead, J., Wilson, I., Bashton, M., Beck, J., West, J., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-06331-w · Cited by 74
Evolutionary Conflict
Queller, D. C., & Strassmann, J. E. (2018) · Annual Review of Ecology Evolution and Systematics · doi:10.1146/annurev-ecolsys-110617-062527 · Cited by 76
Tumor evolutionary directed graphs and the history of chronic lymphocytic leukemia
Wang, J., Khiabanian, H., Rossi, D., Fabbri, G., Gattei, V., Forconi, F., Laurenti, L., Marasca, R., Poeta, G. D., Foà, R., et al. (2014) · eLife · doi:10.7554/elife.02869 · Cited by 71
A novel route to cyclic dominance in voluntary social dilemmas
Guo, H., Song, Z., Geček, S., Li, X., Jusup, M., Perc, M., Moreno, Y., Boccaletti, S., & Wang, Z. (2020) · Journal of The Royal Society Interface · doi:10.1098/rsif.2019.0789 · Cited by 70
Breast cancer stem cells: Obstacles to therapy
Smalley, M. J., Piggott, L., & Clarkson, R. W. E. (2012) · Cancer Letters · doi:10.1016/j.canlet.2012.04.023 · Cited by 75
Assessing the order of critical alterations in prostate cancer development and progression by IHC: further evidence that PTEN loss occurs subsequent to ERG gene fusion
Gümüşkaya, B., Gürel, B., Fedor, H. L., Tan, H.-L., Weier, C. A., Hicks, J. L., Haffner, M. C., Lotan, T. L., & Marzo, A. M. D. (2013) · Prostate Cancer and Prostatic Diseases · doi:10.1038/pcan.2013.8 · Cited by 72
Heterogeneity and Targeting of Pancreatic Cancer Stem Cells
Penchev, V. R., Rasheed, Z. A., Maitra, A., & Matsui, W. H. (2012) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-11-3112 · Cited by 72
Cancer stem cells, cancer-initiating cells and methods for their detection
Akbari‐Birgani, S., Paranjothy, T., Zuse, A., Janikowski, T., Cieślar‐Pobuda, A., Likus, W., Urasińska, E., Schweizer, F., Ghavami, S., Klonisch, T. C., et al. (2016) · Drug Discovery Today · doi:10.1016/j.drudis.2016.03.004 · Cited by 72
Towards the Interpretability of Machine Learning Predictions for Medical Applications Targeting Personalised Therapies: A Cancer Case Survey
Banegas‐Luna, A. J., Peña-García, J. J., Iftene, A., Guadagni, F., Ferroni, P., Scarpato, N., Zanzotto, F. M., Bueno-Crespo, A., & Pérez‐Sánchez, H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094394 · Cited by 77
Ferroptosis and Tumor Drug Resistance: Current Status and Major Challenges
Nie, Z., Chen, M., Gao, Y., Huang, D., Cao, H., Peng, Y., Guo, N., Wang, F., & Zhang, S. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.879317 · Cited by 83
Development and validation of a new high-throughput method to investigate the clonality of HTLV-1-infected cells based on provirus integration sites
Firouzi, S., López, Y., Suzuki, Y., Nakai, K., Sugano, S., Yamochi, T., & Watanabe, T. (2014) · Genome Medicine · doi:10.1186/gm568 · Cited by 74
The evolutionary ecology of transmissible cancers
Újvári, B., Gatenby, R. A., & Frédéric Thomas, A. (2016) · Infection Genetics and Evolution · doi:10.1016/j.meegid.2016.02.005 · Cited by 77
The 3' to 5' Exoribonuclease DIS3: From Structure and Mechanisms to Biological Functions and Role in Human Disease
Robinson, S., Oliver, A., Chevassut, T., & Newbury, S. (2015) · Biomolecules · doi:10.3390/biom5031515 · Cited by 71
Resolving the stem-cell debate
Gilbertson, R. J., & Graham, T. A. (2012) · Nature · doi:10.1038/nature11480 · Cited by 72
Development of synchronous VHL syndrome tumors reveals contingencies and constraints to tumor evolution
Fisher, R. A., Horswell, S. D., Rowan, A., Salm, M. P., de Bruin, E. C., Gulati, S., McGranahan, N., Stares, M., Gerlinger, M., Varela, I., et al. (2014) · Genome biology · doi:10.1186/s13059-014-0433-z · Cited by 77
The pancreatic cancer microenvironment: A true double agent
Melstrom, L. G., Salazar, M. D., & Diamond, D. J. (2017) · Journal of Surgical Oncology · doi:10.1002/jso.24643 · Cited by 74
Targeting cancer stem cells in the clinic: Current status and perspectives
Annett, S., & Robson, T. (2018) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2018.02.001 · Cited by 76
Single-Molecule Genomic Data Delineate Patient-Specific Tumor Profiles and Cancer Stem Cell Organization
Sottoriva, A., Spiteri, I., Shibata, D. K., Curtis, C. N., & Tavaré, S. (2012) · Cancer Research · doi:10.1158/0008-5472.can-12-2273 · Cited by 71
The Convergent Cancer Evolution toward a Single Cellular Destination
Chen, H., & He, X. (2015) · Molecular Biology and Evolution · doi:10.1093/molbev/msv212 · Cited by 71
Centrosome amplification, chromosomal instability and cancer: mechanistic, clinical and therapeutic issues
Cosenza, M. R., & Krämer, A. (2015) · Chromosome Research · doi:10.1007/s10577-015-9505-5 · Cited by 72
Pharmacokinetics and Drug Interactions Determine Optimum Combination Strategies in Computational Models of Cancer Evolution
Chakrabarti, S., & Michor, F. (2017) · Cancer Research · doi:10.1158/0008-5472.can-16-2871 · Cited by 71
ANKRD22 promotes progression of non-small cell lung cancer through transcriptional up-regulation of E2F1
Yin, J., Fu, W., Dai, L., Jiang, Z., Liao, H., Chen, W., Pan, L., & Zhao, J. (2017) · Scientific Reports · doi:10.1038/s41598-017-04818-y · Cited by 71
Neutral tumor evolution?
The PCAWG Evolution and Heterogeneity Working Group, Tarabichi, M., Martincorena, I., Gerstung, M., Leroi, A. M., Markowetz, F. M., Spellman, P. T., Morris, Q., Lingjærde, O. C., Wedge, D. C., et al. (2018) · Nature Genetics · doi:10.1038/s41588-018-0258-x · Cited by 67
Patterns of somatic alterations between matched primary and metastatic colorectal tumors characterized by whole-genome sequencing
Xie, T., Cho, Y. B., Wang, K., Huang, D., Hong, H. K., Choi, Y., Ko, Y. H., Nam, D., Jin, J., Yang, H., et al. (2014) · Genomics · doi:10.1016/j.ygeno.2014.07.012 · Cited by 70
A Single-Nucleotide Substitution Mutator Phenotype Revealed by Exome Sequencing of Human Colon Adenomas
Nikolaev, S. I., Sotiriou, S. K., Pateras, I. S., Santoni, F. A., Sougioultzis, S., Edgren, H., Almusa, H., Robyr, D., Guipponi, M., Saarela, J., et al. (2012) · Cancer Research · doi:10.1158/0008-5472.can-12-3869 · Cited by 70
The roots of cancer: Stem cells and the basis for tumor heterogeneity
Shibata, M., & Shen, M. M. (2012) · BioEssays · doi:10.1002/bies.201200101 · Cited by 72
A high-content image-based method for quantitatively studying context-dependent cell population dynamics
Garvey, C. M., Spiller, E. R., Lindsay, D., Chiang, C.-T., Choi, N. C., Agus, D. B., Mallick, P., Foo, J., & Mumenthaler, S. M. (2016) · Scientific Reports · doi:10.1038/srep29752 · Cited by 69
Difference Makers: Chromosomal Instability versus Aneuploidy in Cancer
van Jaarsveld, R. H., & Kops, G. J. P. L. (2016) · Trends in cancer · doi:10.1016/j.trecan.2016.09.003 · Cited by 71
Intratumoral heterogeneity of oxygen metabolism and neovascularization uncovers 2 survival-relevant subgroups of IDH1 wild-type glioblastoma
Stadlbauer, A., Zimmermann, M., Doerfler, A., Oberndorfer, S., Buchfelder, M., Coras, R., Kitzwögerer, M., & Rössler, K. (2018) · Neuro-Oncology · doi:10.1093/neuonc/noy066 · Cited by 69
Role of circulating tumor cells in future diagnosis and therapy of cancer
Potdar, P. D., & Lotey, N. (2015) · Journal of Cancer Metastasis and Treatment · doi:10.4103/2394-4722.158803 · Cited by 72
The molecular spectrum and clinical impact of DIS 3 mutations in multiple myeloma
Weißbach, S., Langer, C., Puppe, B., Nedeva, T., Bach, E., Kull, M., Bargou, R. C., Einsele, H., Rosenwald, A., Knop, S. T., et al. (2014) · British Journal of Haematology · doi:10.1111/bjh.13256 · Cited by 67
SPARC mediates metastatic cooperation between CSC and non-CSC prostate cancer cell subpopulations
Mateo, F., Meca‐Cortés, Ó., Celià-Terrassa, T., Fernández, Y., Abasolo, I., Sánchez‐Cid, L., Bermudo, R., Sagasta, A., Rodríguez‐Carunchio, L., Pons, M., et al. (2014) · Molecular Cancer · doi:10.1186/1476-4598-13-237 · Cited by 69
Clonal selection and asymmetric distribution of human leukemia in murine xenografts revealed by cellular barcoding
Belderbos, M. E., Koster, T., Dethmers-Ausema, B., Jacobs, S., Sowdagar, S., Zwart, E., de Bont, E. S., de Haan, G., & Bystrykh, L. V. (2017) · Blood · doi:10.1182/blood-2016-12-758250 · Cited by 68

Authors: Greaves, M., & Maley, C. C.
Affiliations: University of California, San Francisco (US)
ORCID: Maley, Carlo C.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2012-01
Volume: 481
Issue: 7381
Pages: 306-313
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature10762
PMC: PMC3367003
OpenAlex: W2023560061
Cited by: 3,162
References: 104
Citations by year: 2026: 180 · 2025: 160 · 2024: 181 · 2023: 225 · 2022: 204 · 2021: 253 · 2020: 229 · 2019: 211 · 2018: 247 · 2017: 296 · 2016: 247 · 2015: 238 · 2014: 221 · 2013: 164 · 2012: 101
FWCI: 17.27
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Funders: National Cancer Institute (R01CA149566, P01CA091955, U54CA143803, P01CA91955, R01CA140657)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer Genomics and Diagnostics
Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
Keywords: clonal evolution, cancer, clonal expansion, genetic diversification, clonal selection, fitness landscape, tumor microenvironment, clonal architecture, drug resistance
MeSH terms: Animals, Clone Cells, Humans, Mutation, Neoplasms, Neoplastic Stem Cells, Genomics, Tumor Microenvironment, Clonal Evolution

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Clonal evolution in cancer

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks