The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Local generation of glia is a major astrocyte source in postnatal cortex
Open accessAbstract
Glial cells constitute nearly 50% of the cells in the human brain. Astrocytes, which make up the largest glial population, are crucial to the regulation of synaptic connectivity during postnatal development. Because defects in astrocyte generation are associated with severe neurological disorders such as brain tumours, it is important to understand how astrocytes are produced. Astrocytes reportedly arise from two sources: radial glia in the ventricular zone and progenitors in the subventricular zone, with the contribution from each region shifting with time. During the first three weeks of postnatal development, the glial cell population, which contains predominantly astrocytes, expands 6-8-fold in the rodent brain. Little is known about the mechanisms underlying this expansion. Here we show that a major source of glia in the postnatal cortex in mice is the local proliferation of differentiated astrocytes. Unlike glial progenitors in the subventricular zone, differentiated astrocytes undergo symmetric division, and their progeny integrate functionally into the existing glial network as mature astrocytes that form endfeet with blood vessels, couple electrically to neighbouring astrocytes, and take up glutamate after neuronal activity.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Astrocytes being the most abundant type of glial cells within cortical areas, are generated from the radial glial cells in the VZ and from the intermediate progenitors in the SVZ after the peak of neurogenesis [53].”
From Development of prefrontal cortex (2022) · cites this paper as [53]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
A robust and high-throughput Cre reporting and characterization system for the whole mouse brain
Madisen, L., Zwingman, T. A., Sunkin, S. M., Oh, S. W., Zariwala, H. A., Gu, H., Ng, L. L., Palmiter, R. D., Hawrylycz, M. J., Jones, A. R., et al. (2010) · Nature Neuroscience · doi:10.1038/nn.2467 · Cited by 6,907
Subventricular zone astrocytes are neural stem cells in the adult mammalian brain
Doetsch, F., Caillé, I., Lim, D. A., García-Verdugo, J. M., & Alvarez-Buylla, A. (1999) · Cell · doi:10.1016/s0092-8674(00)80783-7 · Cited by 3,898
The Glial Nature of Embryonic and Adult Neural Stem Cells
Kriegstein, A., & Alvarez-Buylla, A. (2009) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.051508.135600 · Cited by 2,475
Azevedo, F. A. C., Carvalho, L. R. B., Grinberg, L. T., Farfel, J. M., Ferretti, R. E. L., Leite, R. E. P., Filho, W. J., Lent, R., & Herculano‐Houzel, S. (2009) · Journal of Comparative Neurology · doi:10.1002/cne.21974 · Cited by 2,337
Visualizing Spatiotemporal Dynamics of Multicellular Cell-Cycle Progression
Sakaue-Sawano, A., Kurokawa, H., Morimura, T., Hanyu, A., Hama, H., Osawa, H., Kashiwagi, S., Fukami, K., Miyata, T., Miyoshi, H., et al. (2008) · Cell · doi:10.1016/j.cell.2007.12.033 · Cited by 2,194
Self-citationCell death and control of cell survival in the oligodendrocyte lineage
Barres, B. A., Hart, I. K., Coles, H. S. R., Burne, J. F., Voyvodic, J. T., Richardson, W. D., & Raff, M. C. (1992) · Cell · doi:10.1016/0092-8674(92)90531-g · Cited by 1,345
Astrocyte-mediated control of cerebral blood flow
Takano, T., Tian, G.-F., Peng, W., Lou, N., Libionka, W., Han, X., & Nedergaard, M. (2005) · Nature Neuroscience · doi:10.1038/nn1623 · Cited by 1,137
Epidemiology and molecular pathology of glioma
Schwartzbaum, J., Fisher, J. L., Aldape, K., & Wrensch, M. (2006) · Nature Clinical Practice Neurology · doi:10.1038/ncpneuro0289 · Cited by 951
Astroglial Metabolic Networks Sustain Hippocampal Synaptic Transmission
Rouach, N., Koulakoff, A., Abudara, V., Willecke, K., & Giaume, C. (2008) · Science · doi:10.1126/science.1164022 · Cited by 912
Suh, H., Consiglio, A., Ray, J., Sawai, T., D’Amour, K. A., & Gage, F. H. (2007) · Cell stem cell · doi:10.1016/j.stem.2007.09.002 · Cited by 851
Self-citationMosaic Organization of Neural Stem Cells in the Adult Brain
Merkle, F. T., Mirzadeh, Z., & Álvarez-Buylla, A. (2007) · Science · doi:10.1126/science.1144914 · Cited by 821
Regulation of synaptic connectivity by glia.
Eroglu, C., & Barres, B. A. (2010) · Nature · doi:10.1038/nature09612 · Cited by 813
Origin and progeny of reactive gliosis: A source of multipotent cells in the injured brain
Buffo, A., Rite, I., Tripathi, P., Lepier, A., Colak, D., Horn, A.-P., Mori, T., & Götz, M. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0709002105 · Cited by 789
Levison, S. W., & Goldman, J. E. (1993) · Neuron · doi:10.1016/0896-6273(93)90311-e · Cited by 725
NG2 cells generate both oligodendrocytes and gray matter astrocytes
Zhu, X., Bergles, D. E., & Nishiyama, A. (2007) · Development · doi:10.1242/dev.004895 · Cited by 699
Synaptic Activation of Glutamate Transporters in Hippocampal Astrocytes
Bergles, D. E., & Jahr, C. E. (1997) · Neuron · doi:10.1016/s0896-6273(00)80420-1 · Cited by 523
Age-dependent fate and lineage restriction of single NG2 cells
Zhu, X., Hill, R. A., Dietrich, D., Komitova, M., Suzuki, R., & Nishiyama, A. (2011) · Development · doi:10.1242/dev.047951 · Cited by 464
Matthias, K., Kirchhoff, F., Seifert, G., Hüttmann, K., Matyash, M., Kettenmann, H., & Steinhäuser, C. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-05-01750.2003 · Cited by 436
Changing numbers of neuronal and non-neuronal cells underlie postnatal brain growth in the rat
Bandeira, F., Lent, R., & Herculano‐Houzel, S. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804650106 · Cited by 427
Choice of cranial window type for in vivo imaging affects dendritic spine turnover in the cortex
Xu, H., Pan, F., Yang, G., & Gan, W. (2007) · Nature Neuroscience · doi:10.1038/nn1883 · Cited by 412
Glial cell lineage in the cerebral cortex: A review and synthesis
Cameron, R. S., & RAKIC, P. T. (1991) · Glia · doi:10.1002/glia.440040204 · Cited by 407
Live Astrocytes Visualized by Green Fluorescent Protein in Transgenic Mice
Zhuo, L., Sun, B., Zhang, C.-L., Fine, A., Chiu, S. Y., & Messing, A. (1997) · Developmental Biology · doi:10.1006/dbio.1997.8601 · Cited by 364
Smart, I. H. M., & Leblond, C. P. (1961) · The Journal of Comparative Neurology · doi:10.1002/cne.901160307 · Cited by 274
Li, G., Adesnik, H., Li, J., Long, J., Nicoll, R. A., Rubenstein, J. L. R., & Pleasure, S. J. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.4602-07.2008 · Cited by 209
Long-Term Potentiation of Neuron-Glia Synapses Mediated by Ca 2+ -Permeable AMPA Receptors
Ge, W., Yang, X.-J., Zhang, Z., Wang, H.-K., Shen, W., Deng, Q.-D., & Duan, S. (2006) · Science · doi:10.1126/science.1124669 · Cited by 208
Self-citationZerlin, M., Levison, S. W., & Goldman, J. E. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-11-07238.1995 · Cited by 191
Dye-coupling between glial cells in the guinea pig neocortical slice
Gutnick, M. J., Connors, B. W., & Ransom, B. R. (1981) · Brain Research · doi:10.1016/0006-8993(81)90259-6 · Cited by 158
Marshall, C. A. G., Suzuki, S. O., & Goldman, J. E. (2003) · Glia · doi:10.1002/glia.10213 · Cited by 144
Retrovirus-mediated single-cell gene knockout technique in adult newborn neurons in vivo
Tashiro, A., Zhao, C., & Gage, F. H. (2006) · Nature Protocols · doi:10.1038/nprot.2006.473 · Cited by 139
Self-citationEarly Postnatal Proteolipid Promoter-Expressing Progenitors Produce Multilineage CellsIn Vivo
Guo, F., Ma, J., McCauley, E., Bannerman, P. G. C., & Pleasure, D. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.5653-08.2009 · Cited by 131
Evidence for large-scale astrocyte death in the developing cerebellum
Krueger, B., Burne, J., & Raff, M. C. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-05-03366.1995 · Cited by 120
Ge, W., Zhou, W., Luo, Q., Jan, L. Y., & Jan, Y. N. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0811353106 · Cited by 108
Self-citationCharacterization of astrocyte‐specific conditional knockouts
Casper, K. B., Jones, K. A., & McCarthy, K. D. (2007) · genesis · doi:10.1002/dvg.20287 · Cited by 105
Wang, D. D., Krueger‐Burg, D., & Bordey, A. (2003) · Journal of Neurophysiology · doi:10.1152/jn.01116.2002 · Cited by 76
Burns, K. A., Murphy, B. L., Danzer, S. C., & Kuan, C.-Y. (2008) · Glia · doi:10.1002/glia.20835 · Cited by 69
Ge, W., & Duan, S. (2006) · Journal of Neurophysiology · doi:10.1152/jn.00146.2006 · Cited by 36
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Zhang, Y., Sloan, S. A., Clarke, L. E., Caneda, C., Plaza, C. A., Blumenthal, P. D., Vogel, H., Steinberg, G. K., Edwards, M. S. B., Li, G., et al. (2016) · Neuron · doi:10.1016/j.neuron.2015.11.013 · Cited by 2,295
Verkhratsky, A., & Nedergaard, M. (2018) · Physiological Reviews · doi:10.1152/physrev.00042.2016 · Cited by 1,678
Astrocyte Crosstalk in CNS Inflammation
Linnerbauer, M., Wheeler, M. A., & Quintana, F. J. (2020) · Neuron · doi:10.1016/j.neuron.2020.08.012 · Cited by 989
Astrocyte reactivity and reactive astrogliosis: costs and benefits
Pekny, M., & Pekna, M. (2014) · Physiological Reviews · doi:10.1152/physrev.00041.2013 · Cited by 934
Guo, Z., Zhang, L., Wu, Z., Chen, Y., Wang, F., & Chen, G. (2013) · Cell stem cell · doi:10.1016/j.stem.2013.12.001 · Cited by 849
Metadata
- Authors
- Ge, W.-P., Miyawaki, A., Gage, F. H., Jan, Y. N., & Jan, L. Y.
- Affiliations
- Howard Hughes Medical Institute (US)
- Japan Science and Technology Agency (JP)
- Salk Institute for Biological Studies (US)
- Corresponding author
- Jan, Lily Yeh
- Venue
- Nature
- Published
- 2012-03-28
- Volume
- 484
- Issue
- 7394
- Pages
- 376-380
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC3777276
- OpenAlex
- W2163958669
- Cited by
- 507
- References
- 36
- Citations by year
- 2026: 20 · 2025: 30 · 2024: 44 · 2023: 47 · 2022: 44 · 2021: 40 · 2020: 40 · 2019: 37 · 2018: 30 · 2017: 21 · 2016: 32 · 2015: 42 · 2014: 29 · 2013: 36 · 2012: 14
- FWCI
- 13.02
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institute on Aging (P01AG010435)
- National Institute of Mental Health (R01MH090258, R01MH084234, R37MH065334, MH090258)
- National Institute of Neurological Disorders and Stroke (R00NS073735, K99NS073735)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- astrocyte proliferation, astrocyte endfeet, glutamate uptake, radial glia, symmetric cell division, astrocyte development, mouse brain
- MeSH terms
- Animals, Animals, Newborn, Astrocytes, Cell Differentiation, Cell Division, Cerebral Cortex, Mice, Transgenic, Neuroglia, Glutamic Acid, Cell Lineage, Cell Proliferation, Mice, Time-Lapse Imaging
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
