Cited by 507Neurogenesis and neuroplasticity mechanismsNeuroinflammation and Neurodegeneration MechanismsNeuroscience and Neuropharmacology Research

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Local generation of glia is a major astrocyte source in postnatal cortex

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Ge, Woo-Ping, Miyawaki, Atsushi, Gage, Fred H., Jan, Yuh Nung, Jan, Lily Yeh·2012·Nature

DOI 10.1038/nature10959PMC PMC3777276

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Abstract

Glial cells constitute nearly 50% of the cells in the human brain. Astrocytes, which make up the largest glial population, are crucial to the regulation of synaptic connectivity during postnatal development. Because defects in astrocyte generation are associated with severe neurological disorders such as brain tumours, it is important to understand how astrocytes are produced. Astrocytes reportedly arise from two sources: radial glia in the ventricular zone and progenitors in the subventricular zone, with the contribution from each region shifting with time. During the first three weeks of postnatal development, the glial cell population, which contains predominantly astrocytes, expands 6-8-fold in the rodent brain. Little is known about the mechanisms underlying this expansion. Here we show that a major source of glia in the postnatal cortex in mice is the local proliferation of differentiated astrocytes. Unlike glial progenitors in the subventricular zone, differentiated astrocytes undergo symmetric division, and their progeny integrate functionally into the existing glial network as mature astrocytes that form endfeet with blood vessels, couple electrically to neighbouring astrocytes, and take up glutamate after neuronal activity.

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Authors: Ge, W.-P., Miyawaki, A., Gage, F. H., Jan, Y. N., & Jan, L. Y.
Affiliations: Howard Hughes Medical Institute (US)
Japan Science and Technology Agency (JP)
Salk Institute for Biological Studies (US)
Corresponding author: Jan, Lily Yeh
ORCID: Ge, Woo-Ping
Miyawaki, Atsushi
Gage, Fred H.
Jan, Yuh Nung
Jan, Lily Yeh
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2012-03-28
Volume: 484
Issue: 7394
Pages: 376-380
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature10959
PMC: PMC3777276
OpenAlex: W2163958669
Cited by: 507
References: 36
Citations by year: 2026: 20 · 2025: 30 · 2024: 44 · 2023: 47 · 2022: 44 · 2021: 40 · 2020: 40 · 2019: 37 · 2018: 30 · 2017: 21 · 2016: 32 · 2015: 42 · 2014: 29 · 2013: 36 · 2012: 14
FWCI: 13.02
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Funders: Howard Hughes Medical Institute
National Institute on Aging (P01AG010435)
National Institute of Mental Health (R01MH090258, R01MH084234, R37MH065334, MH090258)
National Institute of Neurological Disorders and Stroke (R00NS073735, K99NS073735)
Topics: Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: astrocyte proliferation, astrocyte endfeet, glutamate uptake, radial glia, symmetric cell division, astrocyte development, mouse brain
MeSH terms: Animals, Animals, Newborn, Astrocytes, Cell Differentiation, Cell Division, Cerebral Cortex, Mice, Transgenic, Neuroglia, Glutamic Acid, Cell Lineage, Cell Proliferation, Mice, Time-Lapse Imaging

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Local generation of glia is a major astrocyte source in postnatal cortex

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