The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Glycolytic oligodendrocytes maintain myelin and long-term axonal integrity
Open accessAbstract
Oligodendrocytes, the myelin-forming glial cells of the central nervous system, maintain long-term axonal integrity. However, the underlying support mechanisms are not understood. Here we identify a metabolic component of axon-glia interactions by generating conditional Cox10 (protoheme IX farnesyltransferase) mutant mice, in which oligodendrocytes and Schwann cells fail to assemble stable mitochondrial cytochrome c oxidase (COX, also known as mitochondrial complex IV). In the peripheral nervous system, Cox10 conditional mutants exhibit severe neuropathy with dysmyelination, abnormal Remak bundles, muscle atrophy and paralysis. Notably, perturbing mitochondrial respiration did not cause glial cell death. In the adult central nervous system, we found no signs of demyelination, axonal degeneration or secondary inflammation. Unlike cultured oligodendrocytes, which are sensitive to COX inhibitors, post-myelination oligodendrocytes survive well in the absence of COX activity. More importantly, by in vivo magnetic resonance spectroscopy, brain lactate concentrations in mutants were increased compared with controls, but were detectable only in mice exposed to volatile anaesthetics. This indicates that aerobic glycolysis products derived from oligodendrocytes are rapidly metabolized within white matter tracts. Because myelinated axons can use lactate when energy-deprived, our findings suggest a model in which axon-glia metabolic coupling serves a physiological function.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source doesn’t support the claim as written.
In the citing paper
“However, there is so far no experimental approach to the question of whether oligodendrocytes release lactate or pyruvate (Fünfschilling et al., 2012) for the support of axonal energy metabolism.”
From Downregulated expression of lactate dehydrogenase in adult oligodendrocytes and its implication for the transfer of glycolysis products to axons (2024) · cites this paper as Fünfschilling et al., 2012
Checked by a reasoning model — may be wrong.
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Remyelination is a crucial regenerative process in demyelinating diseases, limiting persisting damage to the CNS. It restores saltatory nerve conduction and ensures trophic support of axons.”
From BCAS1-positive oligodendrocytes enable efficient cortical remyelination in multiple sclerosis (2025) · cites this paper as [3]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Oligodendrocytes with impaired oxidative phosphorylation instead boost aerobic glycolysis, as indicated by increased lactate levels [127].”
From Oligodendrocyte death and myelin loss in the cuprizone model: an updated overview of the intrinsic and extrinsic causes of cuprizone demyelination (2022) · cites this paper as [127]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“This shift of normal myelin turnover to lipid-based ATP generation allows OLs to share more glucose-derived pyruvate/lactate with the axons to support ATP generation and prevent axon degeneration [278,280].”
From Revisiting the Pathogenesis of X-Linked Adrenoleukodystrophy (2025) · cites this paper as [280]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“This led to a working model of glycolytic oligodendrocytes providing direct metabolic support to axons via non-compacted cytoplasmic channels in myelin and monocarboxylate transporters, which preserves functional integrity and axon survival (Amaral et al., 2013;Fünfschilling et al., 2012;Lee et al., 2012).”
From Downregulated expression of lactate dehydrogenase in adult oligodendrocytes and its implication for the transfer of glycolysis products to axons (2024) · cites this paper as Fünfschilling et al., 2012
Experimental — accuracy not yet measured
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“This is compatible with the idea that adult oligodendrocytes become predominantly glycolytic with a reduced rate of oxidative phosphorylation (OXPHOS) (Fünfschilling et al., 2012).”
From Downregulated expression of lactate dehydrogenase in adult oligodendrocytes and its implication for the transfer of glycolysis products to axons (2024) · cites this paper as Fünfschilling et al., 2012
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Our data are thus compatible with a revised working model of Fünfschilling et al. (2012), in which lactate is preferentially produced in astrocytes close to their gap junctions with neighboring cells, and in which myelinic channels funnel astroglial lactate and oligodendroglial pyruvate to the periaxonal space of myelinated internodes.”
From Downregulated expression of lactate dehydrogenase in adult oligodendrocytes and its implication for the transfer of glycolysis products to axons (2024) · cites this paper as Fünfschilling et al., 2012
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“As oligodendrocytes support axonal energy metabolism and neuronal health4–7, we hypothesized that loss of myelin integrity could be an upstream risk factor for neuronal amyloid-β (Aβ) deposition, the central neuropathological hallmark of AD.”
From Myelin dysfunction drives amyloid-β deposition in models of Alzheimer’s disease (2023) · cites this paper as [5]
The cited source says what the claim attributes to it.
In the citing paper
“Oligodendrocyte-specific deletion of Cox10, which encodes a crucial component for cyt c oxidase assembly and is necessary for oxidative phosphorylation, failed to cause demyelination or neurodegeneration even at 14-months of age.”
From Oligodendrocyte death and myelin loss in the cuprizone model: an updated overview of the intrinsic and extrinsic causes of cuprizone demyelination (2022) · cites this paper as [127]
The cited source says what the claim attributes to it.
In the citing paper
“For example, impaired mitochondrial metabolism alone does not induce oligodendrocyte death in vivo [127].”
From Oligodendrocyte death and myelin loss in the cuprizone model: an updated overview of the intrinsic and extrinsic causes of cuprizone demyelination (2022) · cites this paper as [127]
The cited source says what the claim attributes to it.
In the citing paper
“we found that mature oligodendrocytes survive well in Cox10 (protoheme IX farnesyltransferase)-deficient mice, in which oligodendrocytes lack an assembly factor of stable mitochondrial cytochrome c oxidase (COX, mitochondrial complex IV).”
From Downregulated expression of lactate dehydrogenase in adult oligodendrocytes and its implication for the transfer of glycolysis products to axons (2024) · cites this paper as Fünfschilling et al., 2012
The cited source says what the claim attributes to it.
In the citing paper
“This opens the possibility that glycolytic oligodendrocytes, which are suggested to support electrically active axons with an excess of glycolysis products (Fünfschilling et al., 2012;Lee et al., 2012;Saab et al., 2016;Trevisiol et al., 2017) do so primarily by self-made pyruvate.”
From Downregulated expression of lactate dehydrogenase in adult oligodendrocytes and its implication for the transfer of glycolysis products to axons (2024) · cites this paper as Fünfschilling et al., 2012
In the citing paper
“This confirms that axons readily use lactate for ATP generation”
From Oligodendroglial NMDA receptors regulate glucose import and axonal energy metabolism (2016) · cites this paper as Fünfschilling et al., 2012
In the citing paper
“Myelin modulates the speed of neural impulse conduction (Smith and Koles, 1970; Waxman, 1980), provides metabolic support to axons (Fünfschilling et al., 2012), and exhibits adaptive plasticity (Gibson et al., 2014);”
From Mild respiratory COVID can cause multi-lineage neural cell and myelin dysregulation (2022) · cites this paper as Fünfschilling et al., 2012
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Estimation of metabolite concentrations from localized in vivo proton NMR spectra
Provencher, S. W. (1993) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910300604 · Cited by 3,659
Pellerin, L., & Magistretti, P. J. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.22.10625 · Cited by 2,927
Astrocyte-Neuron Lactate Transport Is Required for Long-Term Memory Formation
Suzuki, A., Stern, S. A., Bozdagi, O., Huntley, G. W., Walker, R. H., Magistretti, P. J., & Alberini, C. M. (2011) · Cell · doi:10.1016/j.cell.2011.02.018 · Cited by 1,711
Disruption of Cnp1 uncouples oligodendroglial functions in axonal support and myelination
Lappe-Siefke, C., Goebbels, S., Gravel, M., Nicksch, E., Lee, J., Braun, P. E., Griffiths, I. R., & Nave, K.-A. (2003) · Nature Genetics · doi:10.1038/ng1095 · Cited by 1,036
Self-citationAxonal Swellings and Degeneration in Mice Lacking the Major Proteolipid of Myelin
Griffiths, I., Klugmann, M., Anderson, T., Yool, D., Thomson, C., Schwab, M. H., Schneider, A., Zimmermann, F., McCulloch, M., Nadon, N., et al. (1998) · Science · doi:10.1126/science.280.5369.1610 · Cited by 889
Self-citationEssential Role for TrkB Receptors in Hippocampus-Mediated Learning
Minichiello, L., Korte, M., Wolfer, D., Kühn, R., Unsicker, K., Cestari, V., Rossi-Arnaud, C., Lipp, H.-P., Bonhoeffer, T., & Klein, R. (1999) · Neuron · doi:10.1016/s0896-6273(00)80853-3 · Cited by 799
Myelination and the trophic support of long axons
Nave, K.-A. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2797 · Cited by 648
Self-citationRegulation of Oligodendrocyte Development and Myelination by Glucose and Lactate
Rinholm, J. E., Hamilton, N. B., Kessaris, N., Richardson, W. D., Bergersen, L. H., & Attwell, D. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.3516-10.2011 · Cited by 383
Mitochondrial potassium transport: the K+ cycle
Garlid, K. D., & Paucek, P. (2003) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(03)00108-7 · Cited by 365
Axonal loss and neuroinflammation caused by peroxisome-deficient oligodendrocytes
Kassmann, C. M., Lappe-Siefke, C., Baes, M., Brügger, B., Mildner, A., Werner, H. B., Natt, O., Michaelis, T., Prinz, M., Frahm, J., et al. (2007) · Nature Genetics · doi:10.1038/ng2070 · Cited by 357
Self-citation
Cited by
Sorted by citations
Items 901–1,000 of 1,000
Metabolic pathways in the periphery and brain: Contribution to mental disorders?
Nagalski, A., Koziński, K., & Wisniewska, M. B. (2016) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2016.09.012 · Cited by 14
Minchenberg, S. B., & Massa, P. T. (2017) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2017.10.015 · Cited by 14
Oligodendrocyte Lineage Marker Expression in eGFP-GFAP Transgenic Mice
Behrangi, N., Lorenz, P., & Kipp, M. (2020) · Journal of Molecular Neuroscience · doi:10.1007/s12031-020-01771-w · Cited by 14
Miettinen, A., Zippo, A. G., Patera, A., Bonnin, A., Shahmoradian, S. H., Biella, G. E. M., & Stampanoni, M. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.03.16.435616 · Cited by 17
Matejuk, A., Matejuk, S., Offner, H., & Vandenbark, A. A. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26178314 · Cited by 14
Lee, J. Y., Biemond, M., & Petratos, S. (2015) · Neurodegenerative Disease Management · doi:10.2217/nmt.15.50 · Cited by 14
Beirowski, B. (2022) · Neurobiology of Disease · doi:10.1016/j.nbd.2022.105751 · Cited by 15
Emamnejad, R., Dass, M., Mahlis, M., Bozkurt, S., Ye, S., Pagnin, M., Theotokis, P., Grigoriadis, N., & Petratos, S. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.934971 · Cited by 14
Frankowska, M., Surówka, P., Gawlińska, K., Borczyk, M., Korostyński, M., Filip, M., & Smaga, I. (2024) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2023.1303718 · Cited by 13
Fernandes, M. G. F., Pernin, F., Antel, J. P., & Kennedy, T. E. (2024) · Journal of Neurochemistry · doi:10.1111/jnc.16219 · Cited by 13
The roles of pleiotrophin in brain injuries: a narrative review of the literature
Lei, Y., Zhou, R., Mao, Q., Qiu, X., & Mu, D. (2025) · Annals of Medicine · doi:10.1080/07853890.2025.2452353 · Cited by 13
Regional analysis of myelin basic protein across postnatal brain development of C57BL/6J mice
Ozarkar, S., Patel, R. K. R., Vulli, T., Friar, C. A., Burette, A. C., & Philpot, B. D. (2025) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2025.1535745 · Cited by 15
Overview of Lipid Biomarkers in Amyotrophic Lateral Sclerosis (ALS)
Trostchansky, A. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-21735-8_18 · Cited by 13
Grinspan, J. B. (2020) · Neurochemical Research · doi:10.1007/s11064-020-02980-w · Cited by 13
Roy, S., Sharma, B., Mazid, M. I., Akhand, M. R. N., Das, M., Marufatuzzahan, M., Chowdhury, T. A., Azim, K. F., & Hasan, M. (2021) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2021.104451 · Cited by 14
Lazari, A., Salvan, P., Verhagen, L., Cottaar, M., Papp, D., van der Werf, O. J., Gavine, B., Kolasinski, J., Webster, M., Stagg, C. J., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-31687-5 · Cited by 14
Tan, X., Liu, X., Liu, E., Liu, M., Mu, S., Hang, Z., Han, W., Wang, T., Zhang, Y., Zhang, J., et al. (2022) · Brain Structure and Function · doi:10.1007/s00429-022-02563-1 · Cited by 13
DCC/netrin-1 regulates cell death in oligodendrocytes after brain injury
Díaz, M. M., Tsenkina, Y., Arizanovska, D., Mehlen, P., & Liebl, D. J. (2022) · Cell Death and Differentiation · doi:10.1038/s41418-022-01091-z · Cited by 13
Uranova, N. A., Vikhreva, O. V., Рахманова, В. И., & Orlovskaya, D. D. (2017) · S S Korsakov Journal of Neurology and Psychiatry · doi:10.17116/jnevro20171179176-81 · Cited by 13
Experimental autoimmune encephalomyelitis from a tissue energy perspective
Desai, R. A., & Smith, K. J. (2017) · F1000Research · doi:10.12688/f1000research.11839.1 · Cited by 13
Azam, A. A., Ismail, I. S., Shaikh, M. F., Shaari, K., & Abas, F. (2019) · Europe PMC (PubMed Central) · doi:10.22038/ajp.2018.11787 · Cited by 13
Pathophysiology and principles of management of the diabetic foot
Armstrong, D. G., Fisher, T. K., Lepow, B. D., White, M. L., & Mills, J. L. (2011) · University of Adelaide Press eBooks · doi:10.1017/upo9781922064004.027 · Cited by 14
Multiple Sclerosis and Other Acquired Demyelinating Diseases of the Central Nervous SystemPreprint
Kornberg, M. D., & Calabresi, P. A. (2024) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a041374 · Cited by 17
Reduced myelin contributes to cognitive impairment in patients with monogenic small vessel disease
Denecke, J., Dewenter, A., Lee, J., Franzmeier, N., Valentim, C., Kopczak, A., Dichgans, M., Pirpamer, L., Gesierich, B. G., Duering, M., et al. (2025) · Alzheimer s & Dementia · doi:10.1002/alz.70127 · Cited by 13
The Influence of Schwann Cell Metabolism and Dysfunction on Axon Maintenance
Follis, R. M., Prabhu, V. V., & Carter, B. D. (2025) · Glia · doi:10.1002/glia.70071 · Cited by 14
Myelin sheaths in the central nervous system can withstand damage and dynamically remodel
Arafa, D., van de Korput, J., Braaker, P. N., Higgins, K. P., Meijns, N., Marshall-Phelps, K. L., Meng, J., Soong, D. Y. H., Scalia, E., Lathem, K., et al. (2026) · Science · doi:10.1126/science.adr4661 · Cited by 15
Moore, E. E., Liu, D., Bown, C. W., Kresge, H. A., Gupta, D. K., Pechman, K. R., Mendes, L. A., Davis, L. T., Gifford, K. A., Anderson, A. W., et al. (2020) · Brain Imaging and Behavior · doi:10.1007/s11682-020-00398-0 · Cited by 14
Murray, C. J., Vecchiarelli, H. A., & Tremblay, M. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2023.1119552 · Cited by 12
Lotun, A., Li, D., Xu, H., Su, Q., Tuncer, S., Sanmiguel, J. C., Mooney, M., Baer, C. E., Ulbrich, R., Eyles, S. J., et al. (2023) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2023.102460 · Cited by 12
Adult‐onset depletion of sulfatide leads to axonal degeneration with relative myelin sparing
Dustin, E., McQuiston, A. R., Honke, K., Palavicini, J. P., Han, X., & Dupree, J. L. (2023) · Glia · doi:10.1002/glia.24423 · Cited by 11
Cell-type specific differences in promoter activity of the ALS-linked C9orf72 mouse ortholog
Langseth, A. J., Kim, J., Ugolino, J., Shah, Y., Hwang, H., Wang, J., Bergles, D. E., & Brown, S. P. (2017) · Scientific Reports · doi:10.1038/s41598-017-05864-2 · Cited by 13
TDP-43 proteinopathy in oligodendrocytes revealed using an induced pluripotent stem cell model
Barton, S. K., Magnani, D., James, O. G., Livesey, M. R., Selvaraj, B. T., James, O. T., Perkins, E., Gregory, J. M., Cleary, E. M., Ausems, C. R. M., et al. (2021) · Brain Communications · doi:10.1093/braincomms/fcab255 · Cited by 12
Shackleford, G., Marziali, L. N., Sasaki, Y., Claessens, A., Ferri, C., Weinstock, N. I., Rossor, A. M., Silvestri, N. J., Wilson, E. R., Hurley, E. L., et al. (2022) · PLoS Genetics · doi:10.1371/journal.pgen.1010477 · Cited by 13
Glial TGFβ activity promotes neuron survival in peripheral nerves
Lassetter, A. P., Corty, M. M., Barría, R., Sheehan, A. E., Hill, J. Q., Aicher, S. A., Fox, A. N., & Freeman, M. R. (2022) · The Journal of Cell Biology · doi:10.1083/jcb.202111053 · Cited by 10
Wootla, B., Watzlawik, J. O., Đenić, A., & Rodriguez, M. (2013) · Expert Review of Clinical Immunology · doi:10.1586/eci.13.37 · Cited by 12
Zhang, M., Ma, Z., Qin, H., & Yao, Z. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-9820-7 · Cited by 12
Taking Advantage of Nature’s Gift: Can Endogenous Neural Stem Cells Improve Myelin Regeneration?
Akkermann, R., Jadasz, J. J., Azim, K., & Küry, P. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17111895 · Cited by 12
Cassoli, J. S., Brandão‐Teles, C., Santana, A. G., Souza, G. H. M. F., & Martins‐de‐Souza, D. (2017) · PROTEOMICS · doi:10.1002/pmic.201700209 · Cited by 12
Axons hooked to Schwann cell metabolism
Tzvetanova, I. D., & Nave, K. (2014) · Nature Neuroscience · doi:10.1038/nn.3825 · Cited by 12
Self-citationRevisiting the Pathogenesis of X-Linked Adrenoleukodystrophy
Bougnères, P., & Le Stunff, C. (2025) · Genes · doi:10.3390/genes16050590 · Cited by 11
Lactate lactylation in neural pathophysiology: Bridging metabolism and neurodegeneration
Cao, M., Yin, Z., Hu, W., Luo, Y., Wang, Q., & Dong, P. (2025) · Neuroscience · doi:10.1016/j.neuroscience.2025.08.048 · Cited by 12
Herbal nanoparticles: a targeted approach for neurodegenerative disorder treatment
Panda, P., & Mohapatra, R. (2024) · Journal of drug targeting · doi:10.1080/1061186x.2024.2391913 · Cited by 11
Lv, Y., Ji, L., Dai, H., Qiu, S., Wang, Y., Teng, C., Yu, B., Mi, D., & Yao, C. (2024) · Experimental Neurology · doi:10.1016/j.expneurol.2024.114966 · Cited by 12
Siems, S. B., Gargareta, V., Schadt, L. C., Gastaldi, V. D., Jung, R. B., Piepkorn, L., Casaccia, P., Sun, T., Jahn, O., & Werner, H. B. (2024) · Glia · doi:10.1002/glia.24614 · Cited by 12
Yanai, H., Adachi, H., Hakoshima, M., & Katsuyama, H. (2024) · Molecules · doi:10.3390/molecules29245936 · Cited by 11
Shan, F., Yao, X., Zhang, Q., Li, R., Kong, L., Zheng, Q., Zhang, N., & Wang, Y. (2025) · Research · doi:10.34133/research.0825 · Cited by 12
Jo, Y. R., Kim, H. R., Jang, S. Y., Go, H., Song, M., Park, D. K., Oh, Y., Jo, J.-Y., Shin, Y. K., Lee, S. J., et al. (2020) · The FASEB Journal · doi:10.1096/fj.202001366rr · Cited by 10
Voon, N. S., Manan, H. A., & Yahya, N. A. (2022) · Strahlentherapie und Onkologie · doi:10.1007/s00066-022-01905-6 · Cited by 11
Wen, L., Yu, T.-H., Ma, Y.-Z., Ma, Y., Ao, T.-R., Javed, R., Ten, H., Matsuno, A., & Ao, Q. (2022) · Neural Regeneration Research · doi:10.4103/1673-5374.350214 · Cited by 11
Merour, E., Hmidan, H., Marie, C., Helou, P.-H., Lu, H., Potel, A., Huré, J.-B., Clavairoly, A., Shih, Y. P., Goudarzi, S., et al. (2022) · eLife · doi:10.7554/elife.80273 · Cited by 11
ELBini-Dhouib, I., & Neili, N.-E. (2023) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2023.02.066 · Cited by 11
Edgar, J. M., & Griffiths, I. R. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-396460-1.00007-x · Cited by 13
Self-citationClinical implications of myelin regeneration in the central nervous system
McMurran, C. E., Kodali, S., Young, A. M. H., & Franklin, R. J. M. (2017) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2018.1421458 · Cited by 11
Jarjour, A. A., Velichkova, A. N., Boyd, A. L., Lord, K. M., Torsney, C., Henderson, D. J., & ffrench‐Constant, C. (2020) · Glia · doi:10.1002/glia.23809 · Cited by 14
Guo, Y., Wu, H., Dong, D., Zhou, F., Li, Z., Zhao, L., & Long, Z. (2022) · Neurobiology of Stress · doi:10.1016/j.ynstr.2022.100511 · Cited by 15
Preparation and Immunostaining of Myelinating Organotypic Cerebellar Slice Cultures
Thétiot, M., Ronzano, R., Aigrot, M., Lubetzki, C., & Desmazières, A. (2019) · Journal of Visualized Experiments · doi:10.3791/59163 · Cited by 22
Pericytes in Multiple Sclerosis
Rivera, F. J., Hinrichsen, B., & Silva, M. E. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-16908-4_8 · Cited by 11
Oligodendroglial Heterogeneity in Neuropsychiatric Disease
Bøstrand, S. M. K., & Williams, A. (2021) · Life · doi:10.3390/life11020125 · Cited by 11
Bao, M., Li, X., Sun, Q.-Q., He, Y., Yin, Y.-J., Li, S.-H., Du, R.-Y., Ma, G.-X., Feng, C.-Y., Han, B., et al. (2026) · Neuron · doi:10.1016/j.neuron.2026.02.032 · Cited by 10
Nsiah, N. Y., & Inman, D. M. (2022) · Cells · doi:10.3390/cells11233756 · Cited by 10
Bioenergetics of Axon Integrity and Its Regulation by Oligodendrocytes and Schwann Cells
Mishra, S. K., & Tiwari, S. P. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-03950-x · Cited by 10
Increased White Matter Aerobic Glycolysis in Multiple Sclerosis
Brier, M. R., Judge, B., Ying, C., Salter, A. R., An, H., Patel, A., Wang, Q., Wang, Y., Cross, A. H., Naismith, R. T., et al. (2024) · Annals of Neurology · doi:10.1002/ana.27165 · Cited by 11
Glial Cells and Aging: From the CNS to the Cerebellum
Sala, G. L., & Farini, D. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26157553 · Cited by 12
Mechanisms of myelin repair, MRI techniques and therapeutic opportunities in multiple sclerosis
Sommer, R. C., Hata, J., Rimkus, C. D. M., da Costa, B. K., Nakahara, J., & Sato, D. K. (2021) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2021.103407 · Cited by 10
Smaga, I. (2022) · Cells · doi:10.3390/cells11030540 · Cited by 11
Tran, N. T., Muccini, A. M., Hale, N., Tolcos, M., Snow, R. J., Walker, D. W., & Ellery, S. J. (2023) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2023.1154772 · Cited by 11
Huang, H., Teng, P., Mei, R., Yang, A., Zhang, Z., Zhao, X., & Qiu, M. S. (2017) · Scientific Reports · doi:10.1038/s41598-017-00407-1 · Cited by 10
Vikhreva, O. V., Рахманова, В. И., Orlovskaya, D. D., & Uranova, N. A. (2018) · S S Korsakov Journal of Neurology and Psychiatry · doi:10.17116/jnevro20181185169 · Cited by 10
He, S., Zhao, Y., Fan, Y., Zhao, X., Yu, J., Xie, J., Wang, C., & Su, J. (2019) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph16071091 · Cited by 10
da Rosa, P. M., Meira-Martins, L. A., Souza, D. O., Bobermin, L. D., Quincozes‐Santos, A., & Leite, M. C. (2019) · Molecular Biology Reports · doi:10.1007/s11033-019-04930-4 · Cited by 9
Mitochondrial Dynamics in Physiology and Pathology of Myelinated Axons
Sui, Y., Nguyen, H. B., Thai, T. Q., Ikenaka, K., & Ohno, N. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-981-32-9636-7_10 · Cited by 10
Gallyas Silver Impregnation of Myelinated Nerve Fibers
Joseph, S., Werner, H. B., & Stegmüller, J. (2019) · BIO-PROTOCOL · doi:10.21769/bioprotoc.3436 · Cited by 9
Hamashima, T., Ishii, Y., Nguyen, L. Q., Okuno, N., Sang, Y., Matsushima, T., Kurashige, Y., Takebayashi, H., Mori, H., Fujimori, T., et al. (2020) · Neuroscience · doi:10.1016/j.neuroscience.2020.04.001 · Cited by 11
Perić, M., Nikolic, L. M., Anđjus, P. R., & Bataveljić, D. (2021) · European Journal of Neuroscience · doi:10.1111/ejn.15451 · Cited by 11
Oligodendrocytes, BK channels and remyelination
Rupnik, M., Baker, D., & Selwood, D. L. (2021) · F1000Research · doi:10.12688/f1000research.53422.1 · Cited by 9
Yamanaka, K., Nakamura, K., Shibahara, T., Takashima, M., Takaki, H., Hidaka, M., Komori, M., Yoshikawa, Y., Wakisaka, Y., Ago, T., et al. (2022) · Glia · doi:10.1002/glia.24292 · Cited by 10
Septins in the glial cells of the nervous system
Patzig, J., Dworschak, M. S., Martens, A., & Werner, H. B. (2013) · Biological Chemistry · doi:10.1515/hsz-2013-0240 · Cited by 10
Oligodendrocytes follow blood vessel trails in the brain
Dejana, E., & Betsholtz, C. (2016) · Science · doi:10.1126/science.aaf1139 · Cited by 11
The Signaling of Neuregulin-Epidermal Growth Factor Receptors and Its Impact on the Nervous System
Tagliaferro, M., & Ponti, D. (2023) · Neuroglia · doi:10.3390/neuroglia4040018 · Cited by 9
Gupta, S. J., Churchward, M. A., Todd, K. G., & Winship, I. R. (2025) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2025.1549433 · Cited by 10
Is age-related myelinodegenerative change an initial risk factor of neurodegenerative diseases?
Wu, S., & Chen, J. (2025) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-24-00848 · Cited by 9
Vervust, W., Safaei, S., Witschas, K., Leybaert, L., & Ghysels, A. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2422437122 · Cited by 10
Lei, H.-P., Yang, X., Hu, Y., Wu, L.-N., Wei, A., Yu, L., Liu, T., Ji, X., Liu, J., Jin, H. J., et al. (2025) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2025.120548 · Cited by 9
Astrocytes as Therapeutic Targets in Neurodegenerative Disorders
Salas, I. H., Alfonso-Triguero, M., Castro, B. D., Elazar, N., Escartin, C., Akl, C. F., Hill, S. A., Quintana, F. J., & Arranz, A. M. (2025) · Journal of Neuroscience · doi:10.1523/jneurosci.1379-25.2025 · Cited by 10
Brain Energy Metabolism: Conserved Functions of Glycolytic Glial Cells
Trevisiol, A., & Nave, K. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.08.010 · Cited by 9
Self-citationEffects on Glial Cell Glycolysis in Schizophrenia: An Advanced Aging Phenotype?
Zuccoli, G. S., Guest, P. C., & Martins‐de‐Souza, D. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-25650-0_2 · Cited by 9
Combination of Probiotics and Natural Compounds to Treat Multiple Sclerosis via Warburg Effect
Ravi, A. K., & Muthukrishnan, S. (2021) · Advanced Pharmaceutical Bulletin · doi:10.34172/apb.2022.057 · Cited by 10
Murlanova, K., Jouroukhin, Y., Huseynov, S., Pletniková, O., Morales, M. J., Guan, Y., Baraban, J. M., Bergles, D. E., & Pletnikov, M. V. (2022) · Glia · doi:10.1002/glia.24169 · Cited by 9
Stanescu, S., Bravo‐Alonso, I., Bélanger-Quintana, A., Pérez, B., Medina-Díaz, M., Ruiz‐Sala, P., Flores, N. P., Buenache, R., Arrieta, F., & Rodríguez‐Pombo, P. (2022) · Orphanet Journal of Rare Diseases · doi:10.1186/s13023-022-02389-4 · Cited by 9
Disease Modifying Strategies in Multiple Sclerosis: New Rays of Hope to Combat Disability?
Bellanca, C. M., Augello, E., Mariottini, A., Bonaventura, G., Cognata, V. L., Benedetto, G. D., Cantone, A. F., Attaguile, G. A., Mauro, R. D., Cantarella, G., et al. (2024) · Current Neuropharmacology · doi:10.2174/1570159x22666240124114126 · Cited by 10
Monocarboxylate Transporter 1 in Brain Diseases and Cancers
Sun, Y., Sun, J., He, Z., Wang, G., Wang, Y., Zhao, D., Wang, Z., Luo, C., Tian, C., & Jiang, Q. (2019) · Current Drug Metabolism · doi:10.2174/1389200220666191021103018 · Cited by 9
Chen, Y., Zhang, Z.-K., Yong He, A., & Zhou, C. (2020) · Cerebral Cortex · doi:10.1093/cercor/bhaa060 · Cited by 11
miR-142-3p regulates cortical oligodendrocyte gene co-expression networks associated with tauopathy
Hinman, J. D., Ngo, K. J., Kim, D., Chen, C.-D., Abraham, C. R., Ghanbari, M., Ikram, M. A., Kushner, S. A., Kawaguchi, R., Coppola, G., et al. (2020) · Human Molecular Genetics · doi:10.1093/hmg/ddaa252 · Cited by 11
Valori, C. F., & Neumann, M. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.724891 · Cited by 9
Monitoring recovery after CNS demyelination, a novel tool to de-risk pro-remyelinating strategies
Henriet, E., Martin, E., Jubin, P., Langui, D., Mannioui, A., Stankoff, B., Lubetzki, C., Khakhalin, A. S., & Zalc, B. (2023) · Brain · doi:10.1093/brain/awad051 · Cited by 9
Martinović, K., Bauer, J., Kunze, M., Berger, J., & Forss‐Petter, S. (2023) · Acta Neuropathologica Communications · doi:10.1186/s40478-023-01595-w · Cited by 10
Remyelination in Multiple Sclerosis: What do we know and Where are we Going?
Williams, A. (2015) · Neurodegenerative Disease Management · doi:10.2217/nmt.14.40 · Cited by 10
Yu, L., Chen, Z., Zhou, X.-L., Teng, F., Bai, Q., Li, L., Li, Y., Liu, Y., Zeng, Q., Wang, Y., et al. (2024) · Journal of Pineal Research · doi:10.1111/jpi.12998 · Cited by 8
Que, X., Zhang, T., Liu, X. Y., Yin, Y., Xia, X., Gong, P., Song, W., Qin, Q., Xu, Q., & Tang, Y. (2025) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2025.102732 · Cited by 8
Kennedy, L., Morland, C., Narum, M., Bergersen, L. H., & Rinholm, J. E. (2025) · eneuro · doi:10.1523/eneuro.0563-24.2025 · Cited by 8
Metadata
- Authors
- Fünfschilling, U., Supplie, L. M., Mahad, D., Boretius, S., Saab, A. S., Edgar, J., Brinkmann, B. G., Kassmann, C. M., Tzvetanova, I. D., Möbius, W., Diaz, F., Meijer, D., Suter, U., Hamprecht, B., Sereda, M. W., Moraes, C. T., Frahm, J., Goebbels, S., & Nave, K.-A.
- Affiliations
- Max Planck Institute of Experimental Medicine (DE)
- Max Planck Society (DE)
- Newcastle University (GB)
- Erasmus MC (NL)
- ETH Zurich (CH)
- University of Miami (US)
- Corresponding author
- Nave, Klaus-Armin
- ORCID
- Venue
- Nature
- Published
- 2012-04-29
- Volume
- 485
- Issue
- 7399
- Pages
- 517-521
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC3613737
- OpenAlex
- W2085029391
- Cited by
- 1,523
- References
- 33
- Citations by year
- 2026: 121 · 2025: 120 · 2024: 127 · 2023: 107 · 2022: 125 · 2021: 142 · 2020: 121 · 2019: 107 · 2018: 91 · 2017: 128 · 2016: 95 · 2015: 93 · 2014: 64 · 2013: 65 · 2012: 13
- FWCI
- 25.34
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Max Planck Institute for Plasma Physics (submittedVersion)
- ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (submittedVersion)
- GRO (submittedVersion, cc-by)
- Edinburgh Research Explorer (University of Edinburgh) (submittedVersion, other-oa)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Funders
- Wellcome Trust (078415)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Keywords
- oligodendrocytes, myelination, aerobic glycolysis, lactate, mitochondrial cytochrome c oxidase, COX10, axonal integrity, demyelination, Schwann cells, white matter, brain lactate, mitochondrial respiration
- MeSH terms
- Action Potentials, Animals, Axons, Brain, Cell Survival, Electron Transport Complex IV, Demyelinating Diseases, Glycolysis, Membrane Proteins, Mitochondria, Myelin Sheath, Magnetic Resonance Spectroscopy, Oligodendroglia, Protons, Schwann Cells, Time Factors, Cell Respiration, Lactic Acid, Alkyl and Aryl Transferases, Mutant Proteins, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
