The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Glycolytic oligodendrocytes maintain myelin and long-term axonal integrity
Open accessAbstract
Oligodendrocytes, the myelin-forming glial cells of the central nervous system, maintain long-term axonal integrity. However, the underlying support mechanisms are not understood. Here we identify a metabolic component of axon-glia interactions by generating conditional Cox10 (protoheme IX farnesyltransferase) mutant mice, in which oligodendrocytes and Schwann cells fail to assemble stable mitochondrial cytochrome c oxidase (COX, also known as mitochondrial complex IV). In the peripheral nervous system, Cox10 conditional mutants exhibit severe neuropathy with dysmyelination, abnormal Remak bundles, muscle atrophy and paralysis. Notably, perturbing mitochondrial respiration did not cause glial cell death. In the adult central nervous system, we found no signs of demyelination, axonal degeneration or secondary inflammation. Unlike cultured oligodendrocytes, which are sensitive to COX inhibitors, post-myelination oligodendrocytes survive well in the absence of COX activity. More importantly, by in vivo magnetic resonance spectroscopy, brain lactate concentrations in mutants were increased compared with controls, but were detectable only in mice exposed to volatile anaesthetics. This indicates that aerobic glycolysis products derived from oligodendrocytes are rapidly metabolized within white matter tracts. Because myelinated axons can use lactate when energy-deprived, our findings suggest a model in which axon-glia metabolic coupling serves a physiological function.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source doesn’t support the claim as written.
In the citing paper
“However, there is so far no experimental approach to the question of whether oligodendrocytes release lactate or pyruvate (Fünfschilling et al., 2012) for the support of axonal energy metabolism.”
From Downregulated expression of lactate dehydrogenase in adult oligodendrocytes and its implication for the transfer of glycolysis products to axons (2024) · cites this paper as Fünfschilling et al., 2012
Checked by a reasoning model — may be wrong.
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Remyelination is a crucial regenerative process in demyelinating diseases, limiting persisting damage to the CNS. It restores saltatory nerve conduction and ensures trophic support of axons.”
From BCAS1-positive oligodendrocytes enable efficient cortical remyelination in multiple sclerosis (2025) · cites this paper as [3]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Oligodendrocytes with impaired oxidative phosphorylation instead boost aerobic glycolysis, as indicated by increased lactate levels [127].”
From Oligodendrocyte death and myelin loss in the cuprizone model: an updated overview of the intrinsic and extrinsic causes of cuprizone demyelination (2022) · cites this paper as [127]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“This shift of normal myelin turnover to lipid-based ATP generation allows OLs to share more glucose-derived pyruvate/lactate with the axons to support ATP generation and prevent axon degeneration [278,280].”
From Revisiting the Pathogenesis of X-Linked Adrenoleukodystrophy (2025) · cites this paper as [280]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“This led to a working model of glycolytic oligodendrocytes providing direct metabolic support to axons via non-compacted cytoplasmic channels in myelin and monocarboxylate transporters, which preserves functional integrity and axon survival (Amaral et al., 2013;Fünfschilling et al., 2012;Lee et al., 2012).”
From Downregulated expression of lactate dehydrogenase in adult oligodendrocytes and its implication for the transfer of glycolysis products to axons (2024) · cites this paper as Fünfschilling et al., 2012
Experimental — accuracy not yet measured
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“This is compatible with the idea that adult oligodendrocytes become predominantly glycolytic with a reduced rate of oxidative phosphorylation (OXPHOS) (Fünfschilling et al., 2012).”
From Downregulated expression of lactate dehydrogenase in adult oligodendrocytes and its implication for the transfer of glycolysis products to axons (2024) · cites this paper as Fünfschilling et al., 2012
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Our data are thus compatible with a revised working model of Fünfschilling et al. (2012), in which lactate is preferentially produced in astrocytes close to their gap junctions with neighboring cells, and in which myelinic channels funnel astroglial lactate and oligodendroglial pyruvate to the periaxonal space of myelinated internodes.”
From Downregulated expression of lactate dehydrogenase in adult oligodendrocytes and its implication for the transfer of glycolysis products to axons (2024) · cites this paper as Fünfschilling et al., 2012
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“As oligodendrocytes support axonal energy metabolism and neuronal health4–7, we hypothesized that loss of myelin integrity could be an upstream risk factor for neuronal amyloid-β (Aβ) deposition, the central neuropathological hallmark of AD.”
From Myelin dysfunction drives amyloid-β deposition in models of Alzheimer’s disease (2023) · cites this paper as [5]
The cited source says what the claim attributes to it.
In the citing paper
“Oligodendrocyte-specific deletion of Cox10, which encodes a crucial component for cyt c oxidase assembly and is necessary for oxidative phosphorylation, failed to cause demyelination or neurodegeneration even at 14-months of age.”
From Oligodendrocyte death and myelin loss in the cuprizone model: an updated overview of the intrinsic and extrinsic causes of cuprizone demyelination (2022) · cites this paper as [127]
The cited source says what the claim attributes to it.
In the citing paper
“For example, impaired mitochondrial metabolism alone does not induce oligodendrocyte death in vivo [127].”
From Oligodendrocyte death and myelin loss in the cuprizone model: an updated overview of the intrinsic and extrinsic causes of cuprizone demyelination (2022) · cites this paper as [127]
The cited source says what the claim attributes to it.
In the citing paper
“we found that mature oligodendrocytes survive well in Cox10 (protoheme IX farnesyltransferase)-deficient mice, in which oligodendrocytes lack an assembly factor of stable mitochondrial cytochrome c oxidase (COX, mitochondrial complex IV).”
From Downregulated expression of lactate dehydrogenase in adult oligodendrocytes and its implication for the transfer of glycolysis products to axons (2024) · cites this paper as Fünfschilling et al., 2012
The cited source says what the claim attributes to it.
In the citing paper
“This opens the possibility that glycolytic oligodendrocytes, which are suggested to support electrically active axons with an excess of glycolysis products (Fünfschilling et al., 2012;Lee et al., 2012;Saab et al., 2016;Trevisiol et al., 2017) do so primarily by self-made pyruvate.”
From Downregulated expression of lactate dehydrogenase in adult oligodendrocytes and its implication for the transfer of glycolysis products to axons (2024) · cites this paper as Fünfschilling et al., 2012
In the citing paper
“This confirms that axons readily use lactate for ATP generation”
From Oligodendroglial NMDA receptors regulate glucose import and axonal energy metabolism (2016) · cites this paper as Fünfschilling et al., 2012
In the citing paper
“Myelin modulates the speed of neural impulse conduction (Smith and Koles, 1970; Waxman, 1980), provides metabolic support to axons (Fünfschilling et al., 2012), and exhibits adaptive plasticity (Gibson et al., 2014);”
From Mild respiratory COVID can cause multi-lineage neural cell and myelin dysregulation (2022) · cites this paper as Fünfschilling et al., 2012
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Estimation of metabolite concentrations from localized in vivo proton NMR spectra
Provencher, S. W. (1993) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910300604 · Cited by 3,659
Pellerin, L., & Magistretti, P. J. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.22.10625 · Cited by 2,927
Astrocyte-Neuron Lactate Transport Is Required for Long-Term Memory Formation
Suzuki, A., Stern, S. A., Bozdagi, O., Huntley, G. W., Walker, R. H., Magistretti, P. J., & Alberini, C. M. (2011) · Cell · doi:10.1016/j.cell.2011.02.018 · Cited by 1,711
Disruption of Cnp1 uncouples oligodendroglial functions in axonal support and myelination
Lappe-Siefke, C., Goebbels, S., Gravel, M., Nicksch, E., Lee, J., Braun, P. E., Griffiths, I. R., & Nave, K.-A. (2003) · Nature Genetics · doi:10.1038/ng1095 · Cited by 1,036
Self-citationAxonal Swellings and Degeneration in Mice Lacking the Major Proteolipid of Myelin
Griffiths, I., Klugmann, M., Anderson, T., Yool, D., Thomson, C., Schwab, M. H., Schneider, A., Zimmermann, F., McCulloch, M., Nadon, N., et al. (1998) · Science · doi:10.1126/science.280.5369.1610 · Cited by 889
Self-citationEssential Role for TrkB Receptors in Hippocampus-Mediated Learning
Minichiello, L., Korte, M., Wolfer, D., Kühn, R., Unsicker, K., Cestari, V., Rossi-Arnaud, C., Lipp, H.-P., Bonhoeffer, T., & Klein, R. (1999) · Neuron · doi:10.1016/s0896-6273(00)80853-3 · Cited by 799
Myelination and the trophic support of long axons
Nave, K.-A. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2797 · Cited by 648
Self-citationRegulation of Oligodendrocyte Development and Myelination by Glucose and Lactate
Rinholm, J. E., Hamilton, N. B., Kessaris, N., Richardson, W. D., Bergersen, L. H., & Attwell, D. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.3516-10.2011 · Cited by 383
Mitochondrial potassium transport: the K+ cycle
Garlid, K. D., & Paucek, P. (2003) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(03)00108-7 · Cited by 365
Axonal loss and neuroinflammation caused by peroxisome-deficient oligodendrocytes
Kassmann, C. M., Lappe-Siefke, C., Baes, M., Brügger, B., Mildner, A., Werner, H. B., Natt, O., Michaelis, T., Prinz, M., Frahm, J., et al. (2007) · Nature Genetics · doi:10.1038/ng2070 · Cited by 357
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Items 601–700 of 1,000
Acetyl‐CoA production from pyruvate is not necessary for preservation of myelin
Nunes, G. D., Mueller, L. E., Silvestri, N. J., Patel, M. S., Wrabetz, L. G., Feltri, M. L., & Poitelon, Y. (2017) · Glia · doi:10.1002/glia.23184 · Cited by 33
Darbelli, L., Choquet, K., Richard, S., & Kleinman, C. L. (2017) · Scientific Reports · doi:10.1038/s41598-017-06211-1 · Cited by 36
Mitochondrial behavior during axon regeneration/degeneration in vivo
Kiryu‐Seo, S., & Kiyama, H. (2018) · Neuroscience Research · doi:10.1016/j.neures.2018.08.014 · Cited by 38
Manukjan, N., Ahmed, Z., Fulton, D. J., Blankesteijn, W. M., & Foulquier, S. (2020) · Cells · doi:10.3390/cells9061545 · Cited by 35
Models and methods to study Schwann cells
Negro, S., Pirazzini, M., & Rigoni, M. (2022) · Journal of Anatomy · doi:10.1111/joa.13606 · Cited by 36
Molecular Mechanisms of Cellular Senescence in Neurodegenerative Diseases
Lee, H.-J., Yoon, Y.-S., & Lee, S.-J. (2023) · Journal of Molecular Biology · doi:10.1016/j.jmb.2023.168114 · Cited by 36
Hackett, M. J., Borondics, F., Brown, D. S., Hirschmugl, C. J., Smith, S., Paterson, P. G., Nichol, H., Pickering, I. J., & George, G. N. (2013) · ACS Chemical Neuroscience · doi:10.1021/cn4000346 · Cited by 35
Li, T., Giaume, C., & Xiao, L. (2014) · Molecular Neurobiology · doi:10.1007/s12035-013-8625-1 · Cited by 38
Peralta, S., García, S., Yin, H. Y., Arguello, T., Díaz, F., & Moraes, C. T. (2016) · Human Molecular Genetics · doi:10.1093/hmg/ddw167 · Cited by 35
Self-citationDietary influence on central nervous system myelin production, injury, and regeneration
Langley, M. R., Triplet, E. M., & Scarisbrick, I. A. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2020.165779 · Cited by 35
Gorter, R. P., & Baron, W. (2020) · Neuroscience Letters · doi:10.1016/j.neulet.2020.134980 · Cited by 37
Progress in progestin-based therapies for neurological disorders
Sitruk-Ware, R. L., Bonsack, B., Brinton, R. D., Schumacher, M., Kumar, N., Lee, J.-Y., Castelli, V., Corey, S., Coats, A. B., Sadanandan, N., et al. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.12.007 · Cited by 36
Lactate as an Astroglial Signal Augmenting Aerobic Glycolysis and Lipid Metabolism
Horvat, A., Zorec, R., & Vardjan, N. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.735532 · Cited by 42
Maki, T., Takahashi, Y. K., Miyamoto, N., Liang, A. C., Ihara, M., Lo, E. H., & Arai, K. (2015) · Stem Cell Research · doi:10.1016/j.scr.2015.05.001 · Cited by 35
Rinholm, J. E., & Bergersen, L. H. (2012) · Nature · doi:10.1038/487435a · Cited by 35
Neuronal culture microenvironments determine preferences in bioenergetic pathway use
Sünwoldt, J., Bosche, B., Meisel, A., & Mergenthaler, P. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00305 · Cited by 34
Replenishing the Aged Brains: Targeting Oligodendrocytes and Myelination?
Zhang, X., Huang, N., Xiao, L., Wang, F., & Li, T. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.760200 · Cited by 32
Age and Alzheimer’s Disease-Related Oligodendrocyte Changes in Hippocampal Subregions
DeFlitch, L., González‐Fernández, E., Crawley, I., & Kang, S. H. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.847097 · Cited by 34
Metabolic dysregulation in Huntington's disease: Neuronal and glial perspectives
Chang, C., Wu, C.-W., & Chern, Y. (2024) · Neurobiology of Disease · doi:10.1016/j.nbd.2024.106672 · Cited by 37
The Role of Glial Cells in the Pathophysiology of Epilepsy
Onat, F., Andersson, M., & Çarçak, N. (2025) · Cells · doi:10.3390/cells14020094 · Cited by 35
Exosome Circuitry During (De)(Re)Myelination of the Central Nervous System
Domingues, H. S., Falcão, A. M., Pinto, I. M., Salgado, A. J., & Teixeira, F. G. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00483 · Cited by 35
Trevisiol, A., Kusch, K., Steyer, A. M., Gregor, I., Nardis, C., Winkler, U., Köhler, S., Restrepo, A., Möbius, W., Werner, H. B., et al. (2020) · PLoS Biology · doi:10.1371/journal.pbio.3000943 · Cited by 35
Self-citationBhusal, A., Rahman, M. H., Lee, W., Lee, I., & Suk, K. (2020) · Glia · doi:10.1002/glia.23942 · Cited by 34
Defective Oligodendroglial Lineage and Demyelination in Amyotrophic Lateral Sclerosis
Traiffort, É., Morisset‐Lopez, S., Moussaed, M., & Zahaf, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22073426 · Cited by 36
Oligodendrocytes in neurodegenerative diseases
Liu, Y., & Zhou, J. (2013) · Frontiers in Biology · doi:10.1007/s11515-013-1260-4 · Cited by 36
Oertel, F. C., Krämer, J., Motamedi, S., Keihani, A., Zimmermann, H. G., Dimitriou, N. G., Condor-Montes, S., Bereuter, C., Cordano, C., Abdelhak, A., et al. (2023) · Neurology Neuroimmunology & Neuroinflammation · doi:10.1212/nxi.0000000000200092 · Cited by 33
Disease-associated oligodendroglia: a putative nexus in neurodegeneration
Castelo‐Branco, G., Kukanja, P., Guerreiro‐Cacais, A. O., & Kirby, L. A. (2024) · Trends in Immunology · doi:10.1016/j.it.2024.08.003 · Cited by 33
Simoes, R. V., Muñoz‐Moreno, E., Cruz-Lemini, M., Eixarch, E., Bargalló, N., Cortés, M. S., & Gratacós, E. (2016) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2016.09.089 · Cited by 33
Samudyata, S., Castelo‐Branco, G., & Liu, J. (2020) · Glia · doi:10.1002/glia.23820 · Cited by 34
Neuronal activity disrupts myelinated axon integrity in the absence of NKCC1b
Marshall-Phelps, K. L., Kegel, L., Baraban, M., Ruhwedel, T., Almeida, R., Rubio-Brotons, M., Klingseisen, A., Benito-Kwiecinski, S. K., Early, J. J., Bin, J. M., et al. (2020) · The Journal of Cell Biology · doi:10.1083/jcb.201909022 · Cited by 33
Self-citationCellular senescence and failure of myelin repair in multiple sclerosis
Koutsoudaki, P. N., Papadopoulos, D., Passias, P.-G., Koutsoudaki, P., & Gorgoulis, V. G. (2020) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2020.111366 · Cited by 33
What Guides Peripheral Immune Cells into the Central Nervous System?
Greiner, T., & Kipp, M. (2021) · Cells · doi:10.3390/cells10082041 · Cited by 33
Satrústegui, J., & Bak, L. K. (2015) · Neurochemical Research · doi:10.1007/s11064-015-1652-8 · Cited by 33
Verden, D. R., & Macklin, W. B. (2016) · Journal of Neuroscience Research · doi:10.1002/jnr.23923 · Cited by 33
Hyperperfusion of Frontal White and Subcortical Gray Matter in Autism Spectrum Disorder
Peterson, B. S., Zargarian, A., Peterson, J. B., Goh, S., Sawardekar, S., Williams, S., Lythgoe, D. J., Zelaya, F. O., & Bansal, R. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2018.11.026 · Cited by 34
Kikel-Coury, N. L., Brandt, J. P., Correia, I. A., O’Dea, M. R., DeSantis, D. F., Sterling, F., Vaughan, K. T., Ozcebe, S. G., Zorlutuna, P., & Smith, C. J. (2021) · PLoS Biology · doi:10.1371/journal.pbio.3001444 · Cited by 36
Todorova, V., Stauffacher, M. F., Ravotto, L., Nötzli, S., Karademir, D., Ebner, L. J. A., Imsand, C., Merolla, L., Hauck, S. M., Samardzija, M., et al. (2023) · Molecular Neurodegeneration · doi:10.1186/s13024-023-00602-x · Cited by 32
Self-citationKawade, N., & Yamanaka, K. (2023) · FEBS Open Bio · doi:10.1002/2211-5463.13661 · Cited by 35
Astrocytic GLUT1 deletion in adult mice enhances glucose metabolism and resilience to stroke
Thieren, L., Zanker, H. S., Droux, J., Dalvi, U., Wyss, M. T., Waag, R., Germain, P., von Ziegler, L., Looser, Z. J., Hösli, L., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-59400-2 · Cited by 38
Self-citationGroh, J., & Martini, R. (2017) · Glia · doi:10.1002/glia.23162 · Cited by 32
Brain energy metabolism and multiple sclerosis: progress and prospects
Park, S. J., & Choi, J. W. (2020) · Archives of Pharmacal Research · doi:10.1007/s12272-020-01278-3 · Cited by 32
Human torpor: translating insights from nature into manned deep space expedition
Shi, Z., Qin, M., Huang, L., Xu, T., Chen, Y., Hu, Q., Peng, S., Peng, Z., Qu, L., Chen, S., et al. (2020) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/brv.12671 · Cited by 31
GluA2 overexpression in oligodendrocyte progenitors promotes postinjury oligodendrocyte regeneration
Khawaja, R. R., Agarwal, A., Fukaya, M., Jeong, H., Gross, S., González‐Fernández, E., Soboloff, J., Bergles, D. E., & Kang, S. H. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109147 · Cited by 31
Köhler, S., Winkler, U., Junge, T., Lippmann, K., Eilers, J., & Hirrlinger, J. (2022) · Glia · doi:10.1002/glia.24268 · Cited by 33
Hypoxia and myelination deficits in the developing brain
Singh, D. K., Ling, E., & Kaur, C. (2018) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2018.06.012 · Cited by 34
The Astrocyte: Metabolic Hub of the BrainPreprint
Barros, L. F., Schirmeier, S., & Weber, B. (2024) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a041355 · Cited by 34
Autophagy and Cellular Senescence in Alzheimer's Disease: Key Drivers of Neurodegeneration
Hussain, M. S., Agrawal, N., Ilma, B., Rekha, M. M., Nayak, P. P., Kaur, M., Khachi, A., Goyal, K., Rekha, A., Gupta, S., et al. (2025) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.70503 · Cited by 35
Microstructure and Cerebral Blood Flow within White Matter of the Human Brain: A TBSS Analysis
Giezendanner, S., Fisler, M. S., Soravia, L. M., Andreotti, J., Walther, S., Wiest, R., Dierks, T., & Federspiel, A. (2016) · PLoS ONE · doi:10.1371/journal.pone.0150657 · Cited by 31
Novel schizophrenia risk factor pathways regulate FEZ1 to advance oligodendroglia development
Chen, X., Ku, L., Mei, R., Liu, G., Xu, C., Wen, Z., Zhao, X., Wang, F., Xiao, L., & Feng, Y. (2017) · Translational Psychiatry · doi:10.1038/s41398-017-0028-z · Cited by 32
Robinson, R. R., Dietz, A. K., Maroof, A. M., Asmis, R., & Forsthuber, T. G. (2019) · Immunotherapy · doi:10.2217/imt-2018-0153 · Cited by 33
Potential Circadian Rhythms in Oligodendrocytes? Working Together Through Time
Colwell, C. S., & Ghiani, C. A. (2019) · Neurochemical Research · doi:10.1007/s11064-019-02778-5 · Cited by 33
Shinjyo, N., & Kita, K. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.765217 · Cited by 29
van Schaik, P. E. M., Zuhorn, I. S., & Baron, W. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23158418 · Cited by 35
Single-Fluorophore Indicator to Explore Cellular and Sub-cellular Lactate Dynamics
Aburto, C., Galaz, A., Bernier, A., Sandoval, P. Y., Holtheuer-Gallardo, S., Ruminot, I., Soto-Ojeda, I., Hertenstein, H., Schweizer, J., Schirmeier, S., et al. (2022) · ACS Sensors · doi:10.1021/acssensors.2c00731 · Cited by 31
Parvalbumin basket cell myelination accumulates axonal mitochondria to internodes
Kole, K., Voesenek, B. J. B., Brinia, M. E., Petersen, N., & Kole, M. H. P. (2022) · Nature Communications · doi:10.1038/s41467-022-35350-x · Cited by 34
Pan, L., Trimarco, A., Zhang, A. J., Fujimori, K., Urade, Y., Sun, L. O., Taveggia, C., & Zhang, Y. (2023) · eLife · doi:10.7554/elife.77441 · Cited by 34
Multicolor analysis of oligodendrocyte morphology, interactions, and development with Brainbow
Dumas, L., Heitz‐Marchaland, C., Fouquet, S., Suter, U., Livet, J., Moreau‐Fauvarque, C., & Chédotal, A. (2014) · Glia · doi:10.1002/glia.22779 · Cited by 35
Self-citationSzymanski, C. R., Chiha, W., Morellini, N. M., Cummins, N., Bartlett, C. A., Doig, R. O., Savigni, D. L., Payne, S. C., Harvey, A. R., Dunlop, S. A., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0066448 · Cited by 31
Imaging Myelination In Vivo Using Transparent Animal Models
Bin, J. M., & Lyons, D. A. (2016) · Brain Plasticity · doi:10.3233/bpl-160029 · Cited by 31
Pathogenicinflammation in the CNS of mice carrying humanPLP1mutations
Groh, J., Friedman, H. C., Orel, N., Ip, C. W., Fischer, S., Spahn, I., Schäffner, E., Hörner, M., Stadler, D., Buttmann, M., et al. (2016) · Human Molecular Genetics · doi:10.1093/hmg/ddw296 · Cited by 31
Kuboyama, K., Tanga, N., Suzuki, R., Fujikawa, A., & Noda, M. (2017) · PLoS ONE · doi:10.1371/journal.pone.0189164 · Cited by 32
Dissecting human cortical similarity networks across the lifespan
Liang, X., Sun, L., Xia, M., Zhao, T., Gong, G., Li, Q., Liao, X., Cui, Z., Duan, D., Pang, C., et al. (2025) · Neuron · doi:10.1016/j.neuron.2025.06.018 · Cited by 34
Francis, J. S., Markov, V., & Leone, P. (2013) · Journal of Inherited Metabolic Disease · doi:10.1007/s10545-013-9663-6 · Cited by 30
The Mitochondrial m-AAA Protease Prevents Demyelination and Hair Greying
Wang, S., Jacquemyn, J., Murru, S., Martinelli, P., Barth, E., Langer, T., Niessen, C. M., & Rugarli, E. I. (2016) · PLoS Genetics · doi:10.1371/journal.pgen.1006463 · Cited by 29
Doig, R. O., Chiha, W., Giacci, M. K., Yates, N. J., Bartlett, C. A., Smith, N. M., Hodgetts, S. I., Harvey, A. R., & Fitzgerald, M. (2017) · BMC Neuroscience · doi:10.1186/s12868-017-0380-1 · Cited by 30
Patro, N., Naik, A. A., & Patro, I. K. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1065-1 · Cited by 30
Intertwined ROS and Metabolic Signaling at the Neuron-Astrocyte Interface
Vicente‐Gutiérrez, C., Jiménez-Blasco, D., & Quintana–Cabrera, R. (2020) · Neurochemical Research · doi:10.1007/s11064-020-02965-9 · Cited by 31
Depletion and activation of microglia impact metabolic connectivity of the mouse brain
Gnörich, J. S., Reifschneider, A., Wind-Mark, K., Zatcepin, A., Kunte, S. T., Beumers, P., Bartos, L. M., Wiedemann, T., Grosch, M., Xiang, X., et al. (2023) · Journal of Neuroinflammation · doi:10.1186/s12974-023-02735-8 · Cited by 32
Mechanisms of Cortical Differentiation
Adnani, L., Han, S., Li, S., Mattar, P. A., & Schuurmans, C. (2017) · International review of cytology · doi:10.1016/bs.ircmb.2017.07.005 · Cited by 33
Harnisch, K. J., Teuber‐Hanselmann, S., Macha, N., Mairinger, F. D., Fritsche, L., Soub, D., Meinl, E., & Junker, A. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20010154 · Cited by 33
Palhol, J. S. C., Balia, M., Terán, F. S.-R., Labarchède, M., Gontier, É., & Battefeld, A. (2023) · Fluids and Barriers of the CNS · doi:10.1186/s12987-023-00425-4 · Cited by 30
Sullivan, J. M., Bagnell, A. M., Alevy, J., Avila, E. M., Mihaljević, L., Saavedra-Rivera, P. C., Kong, L., Huh, J. S., McCray, B. A., Aisenberg, W. H., et al. (2024) · Science Translational Medicine · doi:10.1126/scitranslmed.adk1358 · Cited by 29
Myelin debris phagocytosis in demyelinating disease
Gao, R., Song, S., Tian, M., Wang, L., Zhang, Y., & Li, X. (2024) · Glia · doi:10.1002/glia.24602 · Cited by 31
CLEC16A in astrocytes promotes mitophagy and limits pathology in a multiple sclerosis mouse model
Kadowaki, A., Wheeler, M. A., Li, Z., Andersen, B. M., Lee, H., Illouz, T., Lee, J.-H., Ndayisaba, A., Zandee, S., Basu, H., et al. (2025) · Nature Neuroscience · doi:10.1038/s41593-025-01875-9 · Cited by 30
Claus, L. M., Philippot, C., Griemsmann, S., Timmermann, A., Jabs, R., Henneberger, C., Kettenmann, H., & Steinhäuser, C. (2016) · Cerebral Cortex · doi:10.1093/cercor/bhw368 · Cited by 29
miR-221-3p Inhibits Schwann Cell Myelination
Zhao, L., Yuan, Y., Li, P., Pan, J., Qin, J., Liu, Y., Zhang, Y., Tian, F., Yu, B., & Zhou, S. (2018) · Neuroscience · doi:10.1016/j.neuroscience.2018.03.019 · Cited by 29
Xu, X., Fan, S., Guo, Y., Tan, R., Zhang, J., Zhang, W., Pan, B., & Kato, N. (2019) · Brain and Behavior · doi:10.1002/brb3.1225 · Cited by 28
Modulation of Neural Activity for Myelination in the Central Nervous System
Choi, E. H., Blasiak, A., Lee, J., & Yang, I. H. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00952 · Cited by 30
Human Oligodendrocytes and Myelin In Vitro to Evaluate Developmental Neurotoxicity
Chesnut, M., Härtung, T., Högberg, H. T., & Pamies, D. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22157929 · Cited by 30
A Prospective Viewpoint on Neurological Diseases and Their Biomarkers
Zehravi, M., Kabir, J., Akter, R., Malik, S., Ashraf, G. M., Tagde, P., Ramproshad, S., Mondal, B., Rahman, M. H., Mohan, A. G., et al. (2022) · Molecules · doi:10.3390/molecules27113516 · Cited by 31
Chen, X., Zhang, W., Li, T., Guo, Y., Tian, Y., Wang, F., Liu, S., Shen, H., Feng, Y., & Xiao, L. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00467 · Cited by 30
Stankoff, B., Poirion, É., Tonietto, M., & Bodini, B. (2018) · Brain Pathology · doi:10.1111/bpa.12641 · Cited by 28
Astrocytes regulate neuronal network activity by mediating synapse remodeling
Kim, N., & Chung, W. (2022) · Neuroscience Research · doi:10.1016/j.neures.2022.09.007 · Cited by 31
Narine, M., Azmi, M. A., Umali, M., Volz, A., & Colognato, H. (2023) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2023.1254303 · Cited by 32
Akter, M., Hasan, M., Ramkrishnan, A. S., Zheng, X., Iqbal, Z., Fu, Z., Lei, Z., Karim, A., & Li, Y. (2023) · eLife · doi:10.7554/elife.85751 · Cited by 28
Lipid metabolism and neuroinflammation: What is the link?
Tiwari, V., & Simons, M. (2025) · The Journal of Experimental Medicine · doi:10.1084/jem.20241232 · Cited by 39
Kusch, K., Uecker, M., Liepold, T., Möbius, W., Hoffmann, C., Neumann, H., Werner, H. B., & Jahn, O. (2017) · Proteomes · doi:10.3390/proteomes5010003 · Cited by 29
Self-citationHeterogeneous populations of neural stem cells contribute to myelin repair
Küry, P., Akkermann, R., & Beyer, F. (2017) · Neural Regeneration Research · doi:10.4103/1673-5374.204999 · Cited by 30
Oheim, M., Schmidt, E. M., & Hirrlinger, J. (2017) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2017.04.011 · Cited by 28
CNP deficiency causes severe hypomyelinating leukodystrophy in humans
AlAbdi, L., Murshedi, F. A., Elmanzalawy, A., Habsi, A. A., Helaby, R., Ganesh, A., Ibrahim, N., Patel, N., & Alkuraya, F. S. (2020) · Human Genetics · doi:10.1007/s00439-020-02144-4 · Cited by 27
Ineichen, B. V., Zhu, K., & Carlström, K. E. (2020) · Journal of Neuroscience Research · doi:10.1002/jnr.24767 · Cited by 29
Neuron‐glia (mis)interactions in brain energy metabolism during aging
Mayorga-Weber, G. A., Rivera, F. J., & Castro, M. A. (2022) · Journal of Neuroscience Research · doi:10.1002/jnr.25015 · Cited by 27
Falkai, P., Rossner, M. J., Raabe, F. J., Wagner, E. M., Keeser, D., Maurus, I., Roell, L., Chang, E., Seitz‐Holland, J., Schulze, T. G., et al. (2023) · Schizophrenia Bulletin · doi:10.1093/schbul/sbad065 · Cited by 30
The appropriation of glucose through primate neurodevelopment
Bauernfeind, A. L., & Babbitt, C. C. (2014) · Journal of Human Evolution · doi:10.1016/j.jhevol.2014.05.016 · Cited by 30
Vectorized nanodelivery systems for ischemic stroke: a concept and a need
da Silva‐Candal, A., Argibay, B., Iglesias‐Rey, R., Osorio, Z. V., Prado, A. V., López‐Arias, E., Castro, E. R., López‐Dequidt, I., Rodríguez‐Yáñez, M., Piñeiro, Y., et al. (2017) · Journal of Nanobiotechnology · doi:10.1186/s12951-017-0264-7 · Cited by 28
Dichloroacetate for Cancer Treatment: Some Facts and Many Doubts
Koltai, T., & Fliegel, L. (2024) · Pharmaceuticals · doi:10.3390/ph17060744 · Cited by 28
An Adult Drosophila Glioma Model for Studying Pathometabolic Pathways of Gliomagenesis
Chi, K.-C., Tsai, W., Wu, C., Lin, T., & Hueng, D. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1392-2 · Cited by 27
Neuron–Oligodendrocyte Communication in Myelination of Cortical GABAergic Cells
Mazuir, E., Fricker, D., & Sol‐Foulon, N. (2021) · Life · doi:10.3390/life11030216 · Cited by 27
Sardella-Silva, G., Mietto, B. S., & Ribeiro‐Resende, V. T. (2021) · Biomolecules · doi:10.3390/biom11121887 · Cited by 27
AGC1 Deficiency: Pathology and Molecular and Cellular Mechanisms of the Disease
Pardo, B., Herrada-Soler, E., Satrústegui, J., Contreras, L., & del Arco, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23010528 · Cited by 31
Metadata
- Authors
- Fünfschilling, U., Supplie, L. M., Mahad, D., Boretius, S., Saab, A. S., Edgar, J., Brinkmann, B. G., Kassmann, C. M., Tzvetanova, I. D., Möbius, W., Diaz, F., Meijer, D., Suter, U., Hamprecht, B., Sereda, M. W., Moraes, C. T., Frahm, J., Goebbels, S., & Nave, K.-A.
- Affiliations
- Max Planck Institute of Experimental Medicine (DE)
- Max Planck Society (DE)
- Newcastle University (GB)
- Erasmus MC (NL)
- ETH Zurich (CH)
- University of Miami (US)
- Corresponding author
- Nave, Klaus-Armin
- ORCID
- Venue
- Nature
- Published
- 2012-04-29
- Volume
- 485
- Issue
- 7399
- Pages
- 517-521
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC3613737
- OpenAlex
- W2085029391
- Cited by
- 1,523
- References
- 33
- Citations by year
- 2026: 121 · 2025: 120 · 2024: 127 · 2023: 107 · 2022: 125 · 2021: 142 · 2020: 121 · 2019: 107 · 2018: 91 · 2017: 128 · 2016: 95 · 2015: 93 · 2014: 64 · 2013: 65 · 2012: 13
- FWCI
- 25.34
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Max Planck Institute for Plasma Physics (submittedVersion)
- ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (submittedVersion)
- GRO (submittedVersion, cc-by)
- Edinburgh Research Explorer (University of Edinburgh) (submittedVersion, other-oa)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Funders
- Wellcome Trust (078415)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Keywords
- oligodendrocytes, myelination, aerobic glycolysis, lactate, mitochondrial cytochrome c oxidase, COX10, axonal integrity, demyelination, Schwann cells, white matter, brain lactate, mitochondrial respiration
- MeSH terms
- Action Potentials, Animals, Axons, Brain, Cell Survival, Electron Transport Complex IV, Demyelinating Diseases, Glycolysis, Membrane Proteins, Mitochondria, Myelin Sheath, Magnetic Resonance Spectroscopy, Oligodendroglia, Protons, Schwann Cells, Time Factors, Cell Respiration, Lactic Acid, Alkyl and Aryl Transferases, Mutant Proteins, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
