The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake
Open accessAbstract
How adult tissue stem and niche cells respond to the nutritional state of an organism is not well understood. Here we find that Paneth cells, a key constituent of the mammalian intestinal stem-cell (ISC) niche, augment stem-cell function in response to calorie restriction. Calorie restriction acts by reducing mechanistic target of rapamycin complex 1 (mTORC1) signalling in Paneth cells, and the ISC-enhancing effects of calorie restriction can be mimicked by rapamycin. Calorie intake regulates mTORC1 in Paneth cells, but not ISCs, and forced activation of mTORC1 in Paneth cells during calorie restriction abolishes the ISC-augmenting effects of the niche. Finally, increased expression of bone stromal antigen 1 (Bst1) in Paneth cells—an ectoenzyme that produces the paracrine factor cyclic ADP ribose—mediates the effects of calorie restriction and rapamycin on ISC function. Our findings establish that mTORC1 non-cell-autonomously regulates stem-cell self-renewal, and highlight a significant role of the mammalian intestinal niche in coupling stem-cell function to organismal physiology.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“DR increases intestinal and muscle stem functions through cell-extrinsic mechanisms”
From The Hallmarks of Aging (2013) · cites this paper as Yilmaz et al., 2012
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“mTORC1 inhibition with rapamycin, which can postpone aging by improving proteostasis (see section on Loss of Proteostasis) and by affecting energy sensing (see section on Deregulated Nutrient-sensing), may also improve stem cell function in the epidermis, in the hematopoietic system, and in the intestine”
From The Hallmarks of Aging (2013) · cites this paper as Yilmaz et al., 2012
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“Rapamycin also increases the self-renewal capacity of mouse intestinal stem cells, via a non-cell autonomous mechanism mediated by inhibition of mTORC1 in the adjacent Paneth cells 96.”
From Targeting the biology of aging with mTOR inhibitors (2023) · cites this paper as [96]
In the citing paper
“mTOR, a potent activator of protein translation and inhibitor of autophagy, has been shown to regulate the self-renewal and differentiation of HSCs and intestinal stem cells79,80.”
From Stem cell aging: mechanisms, regulators and therapeutic opportunities (2014) · cites this paper as [79]
In the citing paper
“CR can also enhance or maintain stem cell function during aging by increasing the expression of brain-derived neurotrophic factor in the brain and reducing the mTOR complex 1 (mTORC1) pathway in intestine79,112.”
From Stem cell aging: mechanisms, regulators and therapeutic opportunities (2014) · cites this paper as [79]
In the citing paper
“CR can also enhance or maintain stem cell function during aging by increasing the expression of brain-derived neurotrophic factor in the brain and reducing the mTOR complex 1 (mTORC1) pathway in intestine79,112.”
From Stem cell aging: mechanisms, regulators and therapeutic opportunities (2014) · cites this paper as [79]
In the citing paper
“Paneth cells, found in close association with intestinal stem cells in humans and mice, are an important source of niche factors, including epidermal growth factor, Wnt3A and Notch ligand79,156, although the effect of aging on their activity is yet to be elucidated.”
From Stem cell aging: mechanisms, regulators and therapeutic opportunities (2014) · cites this paper as [79]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche
Sato, T., Vries, R. G., Snippert, H. J., van de Wetering, M., Barker, N., Stange, D. E., van Es, J. H., Abo, A., Kujala, P., Peters, P. J., et al. (2009) · Nature · doi:10.1038/nature07935 · Cited by 7,204
Identification of stem cells in small intestine and colon by marker gene Lgr5
Barker, N., van Es, J. H., Kuipers, J., Kujala, P., van den Born, M., Cozijnsen, M., Haegebarth, A., Korving, J., Begthel, H., Peters, P. J., et al. (2007) · Nature · doi:10.1038/nature06196 · Cited by 5,687
Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts
Sato, T., van Es, J. H., Snippert, H. J., Stange, D. E., Vries, R. G., van den Born, M., Barker, N., Shroyer, N. F., van de Wetering, M., & Clevers, H. (2011) · Nature · doi:10.1038/nature09637 · Cited by 2,510
Prolonged Rapamycin Treatment Inhibits mTORC2 Assembly and Akt/PKB
Sarbassov, D. D., Ali, S. M., Sengupta, S., Sheen, J.-H., Hsu, P. P., Bagley, A. F., Markhard, A. L., & Sabatini, D. M. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.03.029 · Cited by 2,365
Self-citationSnippert, H. J., van der Flier, L. G., Sato, T., van Es, J. H., van den Born, M., Kroon-Veenboer, C., Barker, N., Klein, A. M., van Rheenen, J., Simons, B. D., et al. (2010) · Cell · doi:10.1016/j.cell.2010.09.016 · Cited by 1,951
Bmi1 is expressed in vivo in intestinal stem cells
Sangiorgi, E., & Capecchi, M. R. (2008) · Nature Genetics · doi:10.1038/ng.165 · Cited by 1,245
Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells
Yilmaz, Ö. H., Valdez, R., Theisen, B. K., Guo, W., Ferguson, D. O., Wu, H., & Morrison, S. J. (2006) · Nature · doi:10.1038/nature04703 · Cited by 1,113
Self-citationTranscription Factor Achaete Scute-Like 2 Controls Intestinal Stem Cell Fate
van der Flier, L. G., van Gijn, M. E., Hatzis, P., Kujala, P., Haegebarth, A., Stange, D. E., Begthel, H., van den Born, M., Guryev, V., Oving, I. M., et al. (2009) · Cell · doi:10.1016/j.cell.2009.01.031 · Cited by 752
Interconversion Between Intestinal Stem Cell Populations in Distinct Niches
Takeda, N., Jain, R., LeBoeuf, M. R., Wang, Q., Lu, M. M., & Epstein, J. A. (2011) · Science · doi:10.1126/science.1213214 · Cited by 742
Prominin 1 marks intestinal stem cells that are susceptible to neoplastic transformation
Zhu, L., Gibson, P., Currle, D. S., Tong, Y., Richardson, R. J., Bayazitov, I. T., Poppleton, H., Zakharenko, S. S., Ellison, D. W., & Gilbertson, R. J. (2008) · Nature · doi:10.1038/nature07589 · Cited by 690
Cited by
Sorted by citations
Items 401–500 of 751
Babaei‐Jadidi, R., Kashfi, H., Alelwani, W., Bakhtiari, A. K., Kattan, S. W., Mansouri, O. A., Mukherjee, A., Lobo, D. N., & Nateri, A. S. (2022) · Oncogenesis · doi:10.1038/s41389-021-00376-1 · Cited by 20
Regulation and functions of cell division in the intestinal tissue
Guevara-Garcia, A., Soleilhac, M., Minc, N., & Delacour, D. (2023) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2023.01.004 · Cited by 20
Acarbose suppresses symptoms of mitochondrial disease in a mouse model of Leigh syndrome
Bitto, A., Grillo, A. S., Ito, T. K., Stanaway, I. B., Nguyen, B., Ying, K., Tung, H., Smith, K., Tran, N., Velikanje, G., et al. (2023) · Nature Metabolism · doi:10.1038/s42255-023-00815-w · Cited by 20
Microphysiological systems for human aging research
Park, S., Laskow, T. C., Chen, J., Guha, P., Dawn, B., & Kim, D. (2024) · Aging Cell · doi:10.1111/acel.14070 · Cited by 21
Dietary Walnuts Protect Against Obesity-Driven Intestinal Stem Cell Decline and Tumorigenesis
Guan, F., Tabrizian, T., Novaj, A., Nakanishi, M., Rosenberg, D. W., & Huffman, D. M. (2018) · Frontiers in Nutrition · doi:10.3389/fnut.2018.00037 · Cited by 19
Prolonged Fasting/Refeeding Promotes Hematopoietic Stem Cell Regeneration and Rejuvenation
Mendelsohn, A. R., & Larrick, J. W. (2014) · Rejuvenation Research · doi:10.1089/rej.2014.1595 · Cited by 19
High-Fat Diet and Colorectal Cancer: Myths and Facts
Karunanithi, S., & Levi, L. (2018) · Future Oncology · doi:10.2217/fon-2017-0578 · Cited by 19
Göttert, S., Orberg, E. T., Fan, K., Heinrich, P., Matthe, D. M., Khalid, O., Klostermeier, L., Suriano, C., Strieder, N., Gebhard, C., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-65180-6 · Cited by 22
Filippello, A., Mauro, S. D., Scamporrino, A., Torrisi, S. A., Leggio, G. M., Pino, A. D., Scicali, R., Marco, M. D., Malaguarnera, R., Purrello, F., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23147751 · Cited by 17
HNF4α Acts as Upstream Functional Regulator of Intestinal Wnt3 and Paneth Cell Fate
Jones, C. M., Avino, M., Giroux, V., & Boudreau, F. (2022) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2022.11.010 · Cited by 21
Barnett, B. G., Wesselowski, S. R., Gordon, S. G., Saunders, A. B., Promislow, D., Schwartz, S. M., Chou, L., Evans, J. B., Kaeberlein, M. R., & Creevy, K. E. (2023) · Frontiers in Veterinary Science · doi:10.3389/fvets.2023.1168711 · Cited by 17
Cui, C., Wang, X., Zheng, Y., Li, L., Wang, F., Wei, H., & Peng, J. (2023) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2023.115457 · Cited by 18
Polyploidy and mTOR signaling: a possible molecular link
Choudhury, D., Ghosh, D., Mondal, M., Singha, D., Pothuraju, R., & Malakar, P. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-024-01526-9 · Cited by 20
Bolick, D. T., Chen, T., Alves, L. A. D. O., Tong, Y., Wu, D., Joyner, L. T., Oriá, R. B., Guerrant, R. L., & Fu, Z. (2014) · PLoS ONE · doi:10.1371/journal.pone.0106902 · Cited by 18
Yu, T., Yang, H., Lu, X.-J., Xia, Z., Ouyang, H., Shan, T., Huang, C., & Chen, Q. (2016) · Medical Science Monitor · doi:10.12659/msm.897270 · Cited by 18
Zhang, J., Ye, J., Ren, Y., Zuo, J., Dai, W., He, Y., Tan, M., Wu, S., & Yuan, Y. (2018) · Immunotherapy · doi:10.2217/imt-2018-0122 · Cited by 18
Choi, S., & Snider, A. J. (2019) · International review of cytology · doi:10.1016/bs.ircmb.2019.07.001 · Cited by 17
Neuronal innervation of the intestinal crypt
ten Hove, A. S., Seppen, J., & de Jonge, W. J. (2020) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00239.2020 · Cited by 21
Metabolic Teamwork in the Stem Cell Niche
Roper, J., & Yilmaz, Ö. H. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.04.019 · Cited by 18
Self-citationBerberine enhances the function of intestinal stem cells in healthy and radiation-injured mice
Tu, S., Huang, Y., Tian, H., Xu, L., Wang, X., Huang, L., Lei, X., Xu, Z., & Liu, D. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.112278 · Cited by 17
Coleman, A. E., Creevy, K. E., Anderson, R. M., Reed, M. J., Fajt, V. R., Aicher, K. M., Atiee, G. F., Barnett, B. G., Baumwart, R. D., Boudreau, B., et al. (2025) · GeroScience · doi:10.1007/s11357-024-01484-7 · Cited by 20
Real Time Analysis of Metabolic Profile in Ex Vivo Mouse Intestinal Crypt Organoid Cultures
Bas, T., & Augenlicht, L. H. (2014) · Journal of Visualized Experiments · doi:10.3791/52026 · Cited by 17
Isoprenaline protects intestinal stem cells from chemotherapy‐induced damage
Zeng, H., Li, H., Yue, M., Fan, Y., Cheng, J., Wu, X., Xu, R., Yang, W., Li, M., Tang, J., et al. (2019) · British Journal of Pharmacology · doi:10.1111/bph.14883 · Cited by 16
CD157 enhances malignant pleural mesothelioma aggressiveness and predicts poor clinical outcome
Ortolan, E., Giacomino, A., Martinetto, F., Morone, S., Buono, N. L., Ferrero, E., Scagliotti, G. V., Novello, S., Orecchia, S., Ruffini, E., et al. (2014) · Oncotarget · doi:10.18632/oncotarget.2186 · Cited by 17
CD157: From Myeloid Cell Differentiation Marker to Therapeutic Target in Acute Myeloid Leukemia
Yakymiv, Y., Augeri, S., Fissolo, G., Peola, S., Bracci, C., Binaschi, M., Bellarosa, D., Pellacani, A. U. E., Ferrero, E., Ortolan, E., et al. (2019) · Cells · doi:10.3390/cells8121580 · Cited by 17
Transient Inhibition of mTORC1 Signaling Ameliorates Irradiation-Induced Liver Damage
Yang, W., Shao, L., Zhu, S., Li, H., Zhang, X., Ding, C., Wu, X., Xu, R., Yue, M., Tang, J., et al. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00228 · Cited by 18
Deng, Q., Wang, Y., Wang, X., Wang, Q., Yi, Z., Xia, J., Hu, Y.-Y., Zhang, Y., Wang, J., Wang, L., et al. (2021) · Journal of Animal Science · doi:10.1093/jas/skab002 · Cited by 16
Role of Diet in Stem and Cancer Stem Cells
Puca, F., Fedele, M., Rasio, D., & Battista, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23158108 · Cited by 17
Modulation of stem cell fate in intestinal homeostasis, injury and repair
Wang, Z., Qu, Y.-J., & Cui, M. (2023) · World Journal of Stem Cells · doi:10.4252/wjsc.v15.i5.354 · Cited by 18
Hegab, A. E., Ozaki, M., Meligy, F. Y., Nishino, M., Kagawa, S., Ishii, M., & Betsuyaku, T. (2018) · Journal of Tissue Engineering and Regenerative Medicine · doi:10.1002/term.2792 · Cited by 17
Life style factors, tumor cell plasticity and cancer stem cells
Chiodi, I., & Mondello, C. (2020) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2020.108308 · Cited by 17
A two-front nutritional environment fuels colorectal cancer: perspectives for dietary intervention
Alderweireldt, E., Grootaert, C., Wever, O. D., & Camp, J. V. (2021) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2021.11.002 · Cited by 16
Beyond growth signaling: Paneth cells metabolically support ISCs
Dayton, T. L., & Clevers, H. C. (2017) · Cell Research · doi:10.1038/cr.2017.59 · Cited by 18
CD157 at the intersection between leukocyte trafficking and epithelial ovarian cancer invasion
Buono, N. L. (2014) · Frontiers in bioscience · doi:10.2741/4213 · Cited by 16
Assays for NAD+-Dependent Reactions and NAD+ Metabolites
Schultz, M. B., Lu, Y. R., Braidy, N., & Sinclair, D. A. (2018) · Methods in molecular biology · doi:10.1007/978-1-4939-8588-3_6 · Cited by 15
Drosophila Gut—A Nexus Between Dietary Restriction and Lifespan
Lian, T., Wu, Q., Hodge, B. A., Wilson, K. A., Yu, G., & Yang, M. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19123810 · Cited by 17
Dietary nutrition regulates intestinal stem cell homeostasis
Ma, N., Chen, X., Liu, C., Sun, Y., Johnston, L. J., & Ma, X. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2087052 · Cited by 16
Thyroid hormone signaling in the intestinal stem cells and their niche
Giolito, M. V., & Plateroti, M. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04503-y · Cited by 17
Control of Paneth cell function by HuR regulates gut mucosal growth by altering stem cell activity
Xiao, L., Warner, B., Mallard, C. G., Chung, H. K., Shetty, A. C., Brantner, C. A., Rao, J. N., Yochum, G. S., Koltun, W. A., To, K. B., et al. (2023) · Life Science Alliance · doi:10.26508/lsa.202302152 · Cited by 15
Metabolic and immunologic control of intestinal cell function by mTOR
Fritsch, S. D., & Weichhart, T. (2020) · International Immunology · doi:10.1093/intimm/dxaa015 · Cited by 15
The impact of ageing on lipid-mediated regulation of adult stem cell behavior and tissue homeostasis
Demarco, R. S., Clémot, M., & Jones, D. L. (2020) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2020.111278 · Cited by 16
Niku, M., Pajari, A., Sarantaus, L., Päivärinta, E., Storvik, M., Heiman-Lindh, A., Suokas, S., Nyström, M., & Mutanen, M. L. (2016) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2016.09.016 · Cited by 15
Peña‐Villalobos, I., Casanova-Maldonado, I., Lois, P., Sabat, P., & Palma, V. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2018.01821 · Cited by 17
Metabolic Effects of Caloric Restriction
Lamming, D. W., & Anderson, R. M. (2014) · Wiley eBooks · doi:10.1002/9780470015902.a0021316.pub2 · Cited by 15
Self-citationThe metabolic impact of bacterial infection in the gut
Chaukimath, P., Frankel, G. M., & Visweswariah, S. S. (2022) · FEBS Journal · doi:10.1111/febs.16562 · Cited by 14
Adaptations to chronic rapamycin in mice
Dodds, S. G., Livi, C. B., Parihar, M., Hsu, H.-K., Benavides, A. D., Morris, J., Javors, M. A., Strong, R., Christy, B. A., Hasty, P., et al. (2016) · Pathobiology of Aging & Age-related Diseases · doi:10.3402/pba.v6.31688 · Cited by 15
Recruitment of endogenous CNS stem cells for regeneration in demyelinating disease
Murphy, N. A., & Franklin, R. J. M. (2017) · Progress in brain research · doi:10.1016/bs.pbr.2016.12.013 · Cited by 14
Chewing the Fat with Microbes: Lipid Crosstalk in the Gut
Lemons, J. M. S., & Liu, L. (2022) · Nutrients · doi:10.3390/nu14030573 · Cited by 14
Screening of Intestinal Crypt Organoids: A Simple Readout for Complex Biology
Ley, S., Galuba, O., Salathe, A., Mélin, N., Aebi, A., Pikiolek, M., Knehr, J., Carbone, W., Beibel, M., Nigsch, F., et al. (2017) · SLAS DISCOVERY · doi:10.1177/2472555216683651 · Cited by 14
Trentesaux, C., Striedinger, K., Pomerantz, J. H., & Klein, O. D. (2020) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2020.01.004 · Cited by 15
CD157 and Brain Immune System in (Patho)physiological Conditions: Focus on Brain Plasticity
Lopatina, O. L., Komleva, Y. K., Malinovskaya, N. A., Panina, Y. A., Morgun, A. V., & Salmina, A. B. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.585294 · Cited by 14
The Paneth Cell, Caloric Restriction, and Intestinal Integrity
Clevers, H. C. (2012) · New England Journal of Medicine · doi:10.1056/nejmcibr1208353 · Cited by 14
Pani, G. (2023) · Cancers · doi:10.3390/cancers15092583 · Cited by 16
Dietary regulation of intestinal stem cells in health and disease
Fan, H., Wu, J., Yang, K., Xiong, C., Xiong, S., Wu, X., Fang, Z., Zhu, J., & Huang, J. (2023) · International Journal of Food Sciences and Nutrition · doi:10.1080/09637486.2023.2262780 · Cited by 13
The Use of Calorie Restriction Mimetics to Study Aging
Kitada, M., & Koya, D. (2013) · Methods in molecular biology · doi:10.1007/978-1-62703-556-9_8 · Cited by 14
The eroding chromatin landscape of aging stem cells
Shi, C., Wang, L., & Sen, P. (2020) · Translational Medicine of Aging · doi:10.1016/j.tma.2020.08.002 · Cited by 14
Metabolic Regulation of Stem Cells in Aging
Keller, A. R., Temple, T., Sayanjali, B., & Mihaylova, M. M. (2021) · Current Stem Cell Reports · doi:10.1007/s40778-021-00186-6 · Cited by 14
Weagley, J. S., Zaydman, M. A., Venkatesh, S., Sasaki, Y., Damaraju, N., Yenkin, A. L., Buchser, W., Rodionov, D. A., Osterman, A. L., Ahmed, T., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.110738 · Cited by 13
Tabrizian, T., Wang, D., Guan, F., Hu, Z., Beck, A. P., Delahaye, F., & Huffman, D. M. (2017) · Endocrine Related Cancer · doi:10.1530/erc-16-0536 · Cited by 13
Ferrero, E., Buono, N. L., Morone, S., Parrotta, R., Mancini, C., Brusco, A., Giacomino, A., Augeri, S., Rosal‐Vela, A., García‐Rodríguez, S., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-16184-w · Cited by 13
Bitto, A., Tatom, N., Krivak, T., Grotz, P., & Kaeberlein, M. R. (2021) · Frontiers in Aging · doi:10.3389/fragi.2021.738512 · Cited by 15
Ramos, F. J., & Kaeberlein, M. R. (2012) · Nature · doi:10.1038/486477a · Cited by 14
Visualization of Stem Cell Niche by Fluorescence Lifetime Imaging Microscopy
Okkelman, I. A., Puschhof, J., Papkovsky, D. B., & Dmitriev, R. I. (2020) · Methods in Molecular Biology · doi:10.1007/978-1-0716-0747-3_5 · Cited by 15
Lipoic acid functions in Paneth cells to prevent human intestinal stem cell aging
Zhang, Z., Wan, Q., Zhu, Y., Ye, J., Fu, F., Fan, X., Chen, H., Ren, G., Jiang, W., Guo, X., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-61070-z · Cited by 14
Nutritional interventions for spinal cord injury: preclinical efficacy and molecular mechanisms
Campos, J., Silva, N. A., & Salgado, A. J. (2021) · Nutrition Reviews · doi:10.1093/nutrit/nuab068 · Cited by 12
Translation of Cellular Senescence to Novel Therapeutics: Insights From Alternative Tools and Models
Inci, N., Kamali, D., Akyildiz, E. O., Tahir Turanli, E., & Bozaykut, P. (2022) · Frontiers in Aging · doi:10.3389/fragi.2022.828058 · Cited by 13
Yokoyama, S. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1197265 · Cited by 11
Ayansola, H., Mayorga, E. J., & Jin, Y. (2024) · Biomedicines · doi:10.3390/biomedicines12030668 · Cited by 12
King, S. L., & Dekaney, C. M. (2013) · Current Opinion in Gastroenterology · doi:10.1097/mog.0b013e32835cf253 · Cited by 12
Inoue, T., Nakamura, Y., Tanaka, S., Kohro, T., Li, L. X., Huang, L., Yao, J., Kawamura, S., Inoue, R., Nishi, H., et al. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.993698 · Cited by 12
Role of Wnt signaling in the maintenance and regeneration of the intestinal epithelium
Gasnier, M., Lim, H. Y. G., & Barker, N. (2023) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2023.01.001 · Cited by 14
Chronic Mechanistic Target of Rapamycin Inhibition: Preventing Cancer to Delay Aging, or Vice Versa?
Sharp, Z. D., Curiel, T. J., & Livi, C. B. (2013) · Interdisciplinary topics in gerontology and geriatrics · doi:10.1159/000343625 · Cited by 11
Regulation of Small Intestinal Epithelial Homeostasis by Tsc2-mTORC1 Signaling.
Setiawan, J., Kotani, T., Konno, T., Saito, Y., Murata, Y., Noda, T., & Matozaki, T. (2019) · Europe PMC (PubMed Central) · Cited by 12
Metabolism and Sex Differentiation in Animals from a Starvation Perspective
Sakae, Y., & Tanaka, M. (2021) · Sexual Development · doi:10.1159/000515281 · Cited by 13
Wen, P., Sun, P., & Xi, R. (2010) · Springer eBooks · doi:10.1007/978-90-481-9075-1_3 · Cited by 12
Drosophila activins adapt gut size to food intake and promote regenerative growth
Christensen, C., Laurichesse, Q., Loudhaief, R., Colombani, J., & Andersen, D. S. (2024) · Nature Communications · doi:10.1038/s41467-023-44553-9 · Cited by 11
Şensoy, E. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e31998 · Cited by 11
Fatty acid metabolism: The crossroads in intestinal homeostasis and tumor
Lu, Y., Chen, L., Lin, Y., Zhang, Y., Wang, Y., Yu, W., Ren, F., & Guo, H. (2025) · Metabolism · doi:10.1016/j.metabol.2025.156273 · Cited by 11
Genetically encoded fluorescent reporter for polyamines
Sharma, P., Kim, C. Y., Keys, H. R., Imada, S., Joseph, A. B., Ferro, L. S., Kunchok, T., Anderson, R., Sun, Y., Yilmaz, Ö. H., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-60147-z · Cited by 11
Self-citationMultifactorial causation of early onset colorectal cancer
Lazarova, D. L., & Bordonaro, M. (2021) · Journal of Cancer · doi:10.7150/jca.63676 · Cited by 11
Ma, L., Chen, Y., You, Z.-J., Jiang, Z., Fang, Y., & Dong, L. (2022) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2022.109133 · Cited by 11
Zhang, L., He, Y., Dong, L., Liu, C., Su, L. C., Guo, R., Luo, Q., Gan, B., Cao, F., Wang, Y., et al. (2023) · Cell Proliferation · doi:10.1111/cpr.13427 · Cited by 11
Intestinal epithelial autophagy is required for the regenerative benefit of calorie restriction
Williams, P. A., Naughton, K. E., Simon, L. A., Soto, G. E., Parham, L. R., Ma, X., Danan, C. H., Hu, W., Friedman, E. S., McMillan, E. A., et al. (2023) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00248.2022 · Cited by 11
Guse, A. H. (2023) · Cells · doi:10.3390/cells12040675 · Cited by 11
Polyamines sustain epithelial regeneration in aged intestines by modulating protein homeostasis
Minetti, A., Omrani, O., Brenner, C., Cansiz, F., Imada, S., Rösler, J., Khawaled, S., Allies, G., Meckelmann, S. W., Gebert, N., et al. (2025) · Nature Cell Biology · doi:10.1038/s41556-025-01804-9 · Cited by 11
Self-citationAutophagy at the crossroads of metabolism and cellular defense
Begun, J., & Xavier, R. J. (2013) · Current Opinion in Gastroenterology · doi:10.1097/mog.0b013e328365d34d · Cited by 10
Ye, J., Yuan, K., Dai, W., Sun, K., Li, G., Tan, M., Wu, S., & Yuan, Y. (2018) · International Immunopharmacology · doi:10.1016/j.intimp.2018.12.002 · Cited by 10
RTB101 and immune function in the elderly: Interpreting an unsuccessful clinical trial
Kaeberlein, M. R. (2020) · Translational Medicine of Aging · doi:10.1016/j.tma.2020.01.002 · Cited by 10
Signaling Network Centered on mTORC1 Dominates Mammalian Intestinal Stem Cell Ageing
Liang, S., Zhou, J., & Wang, X. (2020) · Stem Cell Reviews and Reports · doi:10.1007/s12015-020-10073-y · Cited by 10
Paneth cells drive intestinal stem cell competition and clonality in aging and calorie restriction
Annunziata, F., Rasa, S. M. M., Křepelová, A., Lu, J. N., Minetti, A., Omrani, O., Nunna, S., Adam, L., Käppel, S., & Neri, F. (2022) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2022.151282 · Cited by 10
Low temperature and mTOR inhibition favor stem cell maintenance in human keratinocyte cultures
Nanba, D., Sakabe, J., Mosig, J., Brouard, M., Toki, F., Shimokawa, M., Kamiya, M., Braschler, T. M., Azzabi, F., Lathion, S., et al. (2023) · EMBO Reports · doi:10.15252/embr.202255439 · Cited by 9
Advanced Progression for the Heterogeneity and Homeostasis of Intestinal Stem Cells
Sun, M., Tan, Z., Lin, K., Li, X., Zhu, J., Zhan, L., & Zheng, H. (2023) · Stem Cell Reviews and Reports · doi:10.1007/s12015-023-10578-2 · Cited by 10
Fetal-like reversion in the regenerating intestine is regulated by mesenchymal AsporinPreprint
Iqbal, S., Andersson, S., Nestaite, E., Pentinmikko, N., Kumar, A. A., Borshagovski, D., Webb, A., Saarinen, T., Juuti, A., Ori, A., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.06.24.449590 · Cited by 10
Self-citationIsotani, R., Igarashi, M., Miura, M., Naruse, K., Kuranami, S., Katoh, M., Nomura, S., & Yamauchi, T. (2024) · eLife · doi:10.7554/elife.95267 · Cited by 10
Senolytic CAR T cells reverse aging-associated defects in intestinal regeneration and fitnessPreprint
Eskiocak, O., Chowdhury, S., Shah, V., Nnuji-John, E., Chung, C., Boyer, J. A., Harris, A. S., Habel, J., Sadelain, M., Beyaz, S., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.03.19.585779 · Cited by 10
Building better barriers: how nutrition and undernutrition impact pediatric intestinal health
Andres, S. F., Zhang, Y., Kuhn, M. R., & Scottoline, B. P. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1192936 · Cited by 11
Bone marrow stromal cell antigen-1 deficiency protects from acute kidney injury
Inoue, T., Umene, R., Sung, S. J., Tanaka, S., Huang, L., Yao, J., Hashimoto, N., Wu, C.-H., Nakamura, Y., Nishino, T., et al. (2023) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00175.2023 · Cited by 9
Bao, L., Fu, L., Su, Y. P., Chen, Z., Peng, Z., Sun, L., Gonzalez, F. J., Wu, C., Zhang, H., Shi, B., et al. (2024) · International Journal of Biological Sciences · doi:10.7150/ijbs.94297 · Cited by 11
Intestinal stem cells in intestinal homeostasis and colorectal tumorigenesis
Shi, G., Yang, L., Shen, H., He, Q., & Zhu, P. (2024) · Life Medicine · doi:10.1093/lifemedi/lnae042 · Cited by 9
Lauder, E., Kiledal, E. A., Maneix, L., Furnholm, T., Santibanez, A., Zhao, D., Sun, Y., Dick, G. J., & Reddy, P. R. (2025) · Blood · doi:10.1182/blood.2024025924 · Cited by 9
Metadata
- Authors
- Yilmaz, Ö. H., Katajisto, P., Lamming, D. W., Gültekin, Y., Bauer-Rowe, K. E., Sengupta, S., Birsoy, K., Dursun, A., Yilmaz, V. O., Selig, M., Nielsen, G. P., Mino-Kenudson, M., Zukerberg, L. R., Bhan, A. K., Deshpande, V., & Sabatini, D. M.
- Affiliations
- Harvard University (US)
- Broad Institute (US)
- Corresponding author
- Sabatini, David M.
- ORCID
- Venue
- Nature
- Published
- 2012-05-20
- Volume
- 486
- Issue
- 7404
- Pages
- 490-495
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC3387287
- OpenAlex
- W2113486346
- Cited by
- 753
- References
- 33
- Citations by year
- 2026: 38 · 2025: 45 · 2024: 44 · 2023: 58 · 2022: 53 · 2021: 75 · 2020: 69 · 2019: 54 · 2018: 63 · 2017: 56 · 2016: 39 · 2015: 39 · 2014: 52 · 2013: 47 · 2012: 19
- FWCI
- 20.17
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
- RePEc: Research Papers in Economics (submittedVersion)
- DSpace@MIT (Massachusetts Institute of Technology) (submittedVersion, cc-by-nc)
- Funders
- Howard Hughes Medical Institute
- National Institute on Aging (F32AG032833)
- National Cancer Institute (T32CA09216, CA129105, CA103866, R01CA103866, R01CA129105, T32CA009216)
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK043351)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Keywords
- mTORC1, Paneth cells, intestinal stem cells, intestinal stem cell niche, caloric restriction, BST1, cyclic ADP-ribose, paracrine signaling, stem cell self-renewal, intestinal regeneration, nutritional status, rapamycin, lifespan
- MeSH terms
- Mechanistic Target of Rapamycin Complex 1, Animals, Energy Intake, Cell Count, Cell Division, Female, Intestines, Longevity, Male, Proteins, Regeneration, Stem Cells, Signal Transduction, Antigens, CD, Paneth Cells, Paracrine Communication, Sirolimus, Caloric Restriction, ADP-ribosyl Cyclase, Cyclic ADP-Ribose, Multiprotein Complexes, Mice, Stem Cell Niche, TOR Serine-Threonine Kinases, GPI-Linked Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
