The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake
Open accessAbstract
How adult tissue stem and niche cells respond to the nutritional state of an organism is not well understood. Here we find that Paneth cells, a key constituent of the mammalian intestinal stem-cell (ISC) niche, augment stem-cell function in response to calorie restriction. Calorie restriction acts by reducing mechanistic target of rapamycin complex 1 (mTORC1) signalling in Paneth cells, and the ISC-enhancing effects of calorie restriction can be mimicked by rapamycin. Calorie intake regulates mTORC1 in Paneth cells, but not ISCs, and forced activation of mTORC1 in Paneth cells during calorie restriction abolishes the ISC-augmenting effects of the niche. Finally, increased expression of bone stromal antigen 1 (Bst1) in Paneth cells—an ectoenzyme that produces the paracrine factor cyclic ADP ribose—mediates the effects of calorie restriction and rapamycin on ISC function. Our findings establish that mTORC1 non-cell-autonomously regulates stem-cell self-renewal, and highlight a significant role of the mammalian intestinal niche in coupling stem-cell function to organismal physiology.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“DR increases intestinal and muscle stem functions through cell-extrinsic mechanisms”
From The Hallmarks of Aging (2013) · cites this paper as Yilmaz et al., 2012
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“mTORC1 inhibition with rapamycin, which can postpone aging by improving proteostasis (see section on Loss of Proteostasis) and by affecting energy sensing (see section on Deregulated Nutrient-sensing), may also improve stem cell function in the epidermis, in the hematopoietic system, and in the intestine”
From The Hallmarks of Aging (2013) · cites this paper as Yilmaz et al., 2012
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“Rapamycin also increases the self-renewal capacity of mouse intestinal stem cells, via a non-cell autonomous mechanism mediated by inhibition of mTORC1 in the adjacent Paneth cells 96.”
From Targeting the biology of aging with mTOR inhibitors (2023) · cites this paper as [96]
In the citing paper
“mTOR, a potent activator of protein translation and inhibitor of autophagy, has been shown to regulate the self-renewal and differentiation of HSCs and intestinal stem cells79,80.”
From Stem cell aging: mechanisms, regulators and therapeutic opportunities (2014) · cites this paper as [79]
In the citing paper
“CR can also enhance or maintain stem cell function during aging by increasing the expression of brain-derived neurotrophic factor in the brain and reducing the mTOR complex 1 (mTORC1) pathway in intestine79,112.”
From Stem cell aging: mechanisms, regulators and therapeutic opportunities (2014) · cites this paper as [79]
In the citing paper
“CR can also enhance or maintain stem cell function during aging by increasing the expression of brain-derived neurotrophic factor in the brain and reducing the mTOR complex 1 (mTORC1) pathway in intestine79,112.”
From Stem cell aging: mechanisms, regulators and therapeutic opportunities (2014) · cites this paper as [79]
In the citing paper
“Paneth cells, found in close association with intestinal stem cells in humans and mice, are an important source of niche factors, including epidermal growth factor, Wnt3A and Notch ligand79,156, although the effect of aging on their activity is yet to be elucidated.”
From Stem cell aging: mechanisms, regulators and therapeutic opportunities (2014) · cites this paper as [79]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche
Sato, T., Vries, R. G., Snippert, H. J., van de Wetering, M., Barker, N., Stange, D. E., van Es, J. H., Abo, A., Kujala, P., Peters, P. J., et al. (2009) · Nature · doi:10.1038/nature07935 · Cited by 7,204
Identification of stem cells in small intestine and colon by marker gene Lgr5
Barker, N., van Es, J. H., Kuipers, J., Kujala, P., van den Born, M., Cozijnsen, M., Haegebarth, A., Korving, J., Begthel, H., Peters, P. J., et al. (2007) · Nature · doi:10.1038/nature06196 · Cited by 5,687
Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts
Sato, T., van Es, J. H., Snippert, H. J., Stange, D. E., Vries, R. G., van den Born, M., Barker, N., Shroyer, N. F., van de Wetering, M., & Clevers, H. (2011) · Nature · doi:10.1038/nature09637 · Cited by 2,510
Prolonged Rapamycin Treatment Inhibits mTORC2 Assembly and Akt/PKB
Sarbassov, D. D., Ali, S. M., Sengupta, S., Sheen, J.-H., Hsu, P. P., Bagley, A. F., Markhard, A. L., & Sabatini, D. M. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.03.029 · Cited by 2,365
Self-citationSnippert, H. J., van der Flier, L. G., Sato, T., van Es, J. H., van den Born, M., Kroon-Veenboer, C., Barker, N., Klein, A. M., van Rheenen, J., Simons, B. D., et al. (2010) · Cell · doi:10.1016/j.cell.2010.09.016 · Cited by 1,951
Bmi1 is expressed in vivo in intestinal stem cells
Sangiorgi, E., & Capecchi, M. R. (2008) · Nature Genetics · doi:10.1038/ng.165 · Cited by 1,245
Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells
Yilmaz, Ö. H., Valdez, R., Theisen, B. K., Guo, W., Ferguson, D. O., Wu, H., & Morrison, S. J. (2006) · Nature · doi:10.1038/nature04703 · Cited by 1,113
Self-citationTranscription Factor Achaete Scute-Like 2 Controls Intestinal Stem Cell Fate
van der Flier, L. G., van Gijn, M. E., Hatzis, P., Kujala, P., Haegebarth, A., Stange, D. E., Begthel, H., van den Born, M., Guryev, V., Oving, I. M., et al. (2009) · Cell · doi:10.1016/j.cell.2009.01.031 · Cited by 752
Interconversion Between Intestinal Stem Cell Populations in Distinct Niches
Takeda, N., Jain, R., LeBoeuf, M. R., Wang, Q., Lu, M. M., & Epstein, J. A. (2011) · Science · doi:10.1126/science.1213214 · Cited by 742
Prominin 1 marks intestinal stem cells that are susceptible to neoplastic transformation
Zhu, L., Gibson, P., Currle, D. S., Tong, Y., Richardson, R. J., Bayazitov, I. T., Poppleton, H., Zakharenko, S. S., Ellison, D. W., & Gilbertson, R. J. (2008) · Nature · doi:10.1038/nature07589 · Cited by 690
Cited by
Sorted by citations
Items 201–300 of 751
TSC2/mTORC1 signaling controls Paneth and goblet cell differentiation in the intestinal epithelium
Zhou, Y., Rychahou, P. G., Wang, Q., Weiss, H. L., & Evers, B. M. (2015) · Cell Death and Disease · doi:10.1038/cddis.2014.588 · Cited by 72
Transit-Amplifying Cells Coordinate Changes in Intestinal Epithelial Cell-Type Composition
Sanman, L. E., Chen, I. W., Bieber, J. M., Steri, V., Trentesaux, C., Hann, B. C., Klein, O. D., Wu, L. F., & Altschuler, S. J. (2021) · Developmental Cell · doi:10.1016/j.devcel.2020.12.020 · Cited by 66
Reactive Oxygen Species in intestinal stem cell metabolism, fate and function
Morris, O., & Jasper, H. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.02.015 · Cited by 70
The role of mTOR in age-related diseases
Chrienová, Ž., Nepovimová, E., & Kuča, K. (2021) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.1080/14756366.2021.1955873 · Cited by 72
Aging of intestinal stem cells
Nalapareddy, K., Zheng, Y., & Geiger, H. (2022) · Stem Cell Reports · doi:10.1016/j.stemcr.2022.02.003 · Cited by 70
eRapa Restores a Normal Life Span in a FAP Mouse Model
Hasty, P., Livi, C. B., Dodds, S. G., Jones, D., Strong, R., Javors, M. A., Fischer, K. E., Sloane, L. B., Murthy, K., Hubbard, G. B., et al. (2013) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-13-0299 · Cited by 69
LRRK2 but not ATG16L1 is associated with Paneth cell defect in Japanese Crohn’s disease patients
Liu, T., Naito, T., Liu, Z., VanDussen, K. L., Haritunians, T., Li, D., Endo, K., Kawai, Y., Nagasaki, M., Kinouchi, Y., et al. (2017) · JCI Insight · doi:10.1172/jci.insight.91917 · Cited by 69
DNA Methylation Analysis Validates Organoids as a Viable Model for Studying Human Intestinal Aging
Lewis, S., Nachun, D. C., Martı́n, M. G., Horvath, S., Coppola, G., & Jones, D. L. (2019) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2019.11.013 · Cited by 70
Miao, Z., Adkins-Threats, M., Burclaff, J., Osaki, L. H., Sun, J.-X., Kefalov, Y., He, Z., Wang, Z.-N., & Mills, J. C. (2020) · Cell stem cell · doi:10.1016/j.stem.2020.03.006 · Cited by 71
Evaluation of off-label rapamycin use to promote healthspan in 333 adults
Kaeberlein, T. L., Green, A. S., Haddad, G., Hudson, J., Isman, A., Nyquist, A., Rosen, B. S., Suh, Y., Zalzala, S., Zhang, X., et al. (2023) · GeroScience · doi:10.1007/s11357-023-00818-1 · Cited by 66
Genetic Pathways of Aging and Their Relevance in the Dog as a Natural Model of Human Aging
Sándor, S., & Kubinyi, E. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.00948 · Cited by 68
Glutamine and alanyl-glutamine promote crypt expansion and mTOR signaling in murine enteroids
Moore, S. R., Guedes, M. M., Costa, T. B., Vallance, J. E., Maier, E. A., Betz, K., Aihara, E., Mahé, M. M., Lima, A. Â. M., Oriá, R. B., et al. (2015) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00422.2014 · Cited by 66
Hallmarks of intestinal stem cells
Baulies, A., Angelis, N., & Li, V. S. W. (2020) · Development · doi:10.1242/dev.182675 · Cited by 71
Ageing in the brain: mechanisms and rejuvenating strategies
Gaspar-Silva, F., Trigo, D., & Magalhães, J. (2023) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-023-04832-6 · Cited by 88
Nutritional Regulation of Intestinal Stem Cells
Alonso, S., & Yilmaz, Ö. H. (2018) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-082117-051644 · Cited by 66
Self-citationDistinct germline progenitor subsets defined through Tsc2–mTORC1 signaling
Hobbs, R. M., La, H. M., Mäkelä, J., Kobayashi, T., Noda, T., & Pandolfi, P. P. (2015) · EMBO Reports · doi:10.15252/embr.201439379 · Cited by 65
Zullo, A., Simone, E., Grimaldi, M., Musto, V., & Mancini, F. P. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19040928 · Cited by 67
de Cavanagh, E. M. V., Inserra, F., & Ferder, L. (2015) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00459.2014 · Cited by 66
Caloric Restriction Promotes Structural and Metabolic Changes in the Skin
Forni, M. F., Peloggia, J., Braga, T. T., Chinchilla, J. E. O., Shinohara, J. S., Navas, C. A., Câmara, N. O. S., & Kowaltowski, A. J. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.08.052 · Cited by 64
CD38 Is Expressed on Inflammatory Cells of the Intestine and Promotes Intestinal Inflammation
Schneider, M., Schumacher, V., Lischke, T., Lücke, K., Meyer-Schwesinger, C., Velden, J., Koch-Nolte, F., & Mittrücker, H.-W. (2015) · PLOS ONE · doi:10.1371/journal.pone.0126007 · Cited by 62
The Mechanism of Stem Cell Aging
Mi, L., Hu, J., Li, N., Gao, J., Huo, R., Peng, X., Zhang, N., Liu, Y., Zhao, H., Liu, R., et al. (2022) · Stem Cell Reviews and Reports · doi:10.1007/s12015-021-10317-5 · Cited by 64
Brain response to calorie restriction
Fusco, S., & Pani, G. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-1223-y · Cited by 68
Cellular shape reinforces niche to stem cell signaling in the small intestine
Pentinmikko, N., Lozano, R., Scharaw, S., Andersson, S., Englund, J. I., Castillo‐Azofeifa, D., Gallagher, A. P., Broberg, M. E., Song, K.-Y., Sola-Carvajal, A., et al. (2022) · Science Advances · doi:10.1126/sciadv.abm1847 · Cited by 59
Self-citationYY1 is indispensable for Lgr5 + intestinal stem cell renewal
Perekatt, A. O., Valdez, M. J., Davila, M., Hoffman, A., Bonder, E. M., Gao, N., & Verzi, M. P. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1400128111 · Cited by 61
Glucose and amino acid in enterocyte absorption metabolism and maturation
Yang, H. (2018) · Frontiers in bioscience · doi:10.2741/4669 · Cited by 61
Regeneration, rejuvenation, and replacement: turning back the clock on tissue aging
Rando, T. A., & Jones, D. L. (2021) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a040907 · Cited by 63
Yang, H., & Yamashita, Y. M. (2015) · Development · doi:10.1242/dev.122663 · Cited by 55
Cellular Mechanisms of Somatic Stem Cell Aging
Jung, Y., & Brack, A. S. (2014) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/b978-0-12-416022-4.00014-7 · Cited by 63
Mi, W., Ye, Q., Liu, S., & She, Q. (2015) · Oncotarget · doi:10.18632/oncotarget.3920 · Cited by 61
Spatial discordances between mRNAs and proteins in the intestinal epithelium
Harnik, Y., Buchauer, L., Ben‐Moshe, S., Averbukh, I., Levin, Y., Savidor, A., Eilam, R., Moor, A. E., & Itzkovitz, S. (2021) · Nature Metabolism · doi:10.1038/s42255-021-00504-6 · Cited by 56
Gancz, D., & Gilboa, L. (2013) · Development · doi:10.1242/dev.093773 · Cited by 60
CD157: From immunoregulatory protein to potential therapeutic target
Ortolan, E., Augeri, S., Fissolo, G., Musso, I., & Funaro, A. (2018) · Immunology Letters · doi:10.1016/j.imlet.2018.06.007 · Cited by 59
B cells as a critical node in the microbiota–host immune system network
Slack, E. M. C., Balmer, M. L., & Macpherson, A. J. (2014) · Immunological Reviews · doi:10.1111/imr.12179 · Cited by 66
CD38, CD157, and RAGE as Molecular Determinants for Social Behavior
Higashida, H., Hashii, M., Tanaka, Y., Matsukawa, S., Higuchi, Y., Gabata, R., Tsubomoto, M., Seishima, N., Teramachi, M., Kamijima, T., et al. (2019) · Cells · doi:10.3390/cells9010062 · Cited by 58
Beyond the Niche: Tissue-Level Coordination of Stem Cell Dynamics
O’Brien, L. E., & Bilder, D. H. (2013) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-101512-122319 · Cited by 60
Bruens, L., Ellenbroek, S. I. J., Suijkerbuijk, S. J. E., Azkanaz, M., Hale, A. J., Toonen, P. W., Flanagan, D. J., Sansom, O. J., Snippert, H. J. G., & van Rheenen, J. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.107937 · Cited by 58
Wilson, K. A., Chamoli, M., Hilsabeck, T. A. U., Pandey, M., Bansal, S., Chawla, G., & Kapahi, P. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2021.08.018 · Cited by 57
Inflammation-induced epigenetic imprinting regulates intestinal stem cells
Zhao, D., Ravikumar, V., Leach, T. J., Kraushaar, D. C., Lauder, E., Li, L., Sun, Y., Oravecz-Wilson, K. I., Keller, E. T., Chen, F., et al. (2024) · Cell stem cell · doi:10.1016/j.stem.2024.08.006 · Cited by 58
Dietary Regulation of Adult Stem Cells
Mana, M., Kuo, E. Y.-S., & Yilmaz, Ö. H. (2017) · Current Stem Cell Reports · doi:10.1007/s40778-017-0072-x · Cited by 57
Self-citationAn immunohistochemical, enzymatic, and behavioral study of CD157/BST-1 as a neuroregulator
Higashida, H., Liang, M., Yoshihara, T., Akther, S., Fakhrul, A. A. K. M., Михайлович, Ч. С., Nam, T., Kim, U., Kasai, S., Nishimura, T., et al. (2017) · BMC Neuroscience · doi:10.1186/s12868-017-0350-7 · Cited by 56
Hattori, T., Kaji, M., Ishii, H., Jureepon, R., Takarada-Iemata, M., Minh Ta, H., Manh Le, T., Konno, A., Hirai, H., Shiraishi, Y., et al. (2017) · Glia · doi:10.1002/glia.23139 · Cited by 53
Akagi, K., Wilson, K. A., Katewa, S. D., Ortega, M., Simons, J., Hilsabeck, T. A. U., Kapuria, S., Sharma, A., Jasper, H., & Kapahi, P. (2018) · PLoS Genetics · doi:10.1371/journal.pgen.1007777 · Cited by 53
Microbial Metabolites and Intestinal Stem Cells Tune Intestinal Homeostasis
Xing, P. Y., Pettersson, S., & Kundu, P. (2020) · PROTEOMICS · doi:10.1002/pmic.201800419 · Cited by 55
The microRNA miR-235 couples blast-cell quiescence to the nutritional state
Hidefumi, K., Fukuyama, M., Aya, K., Kontani, K., & Katada, T. (2013) · Nature · doi:10.1038/nature12117 · Cited by 52
Luo, M.-J., Rao, S., Tan, Y., Yin, H., Hu, X., Zhang, Y., Liu, Y.-W., Yue, T., Chen, L.-J., Li, L., et al. (2020) · Theranostics · doi:10.7150/thno.44115 · Cited by 54
Brandt, M., Grazioso, T. P., Fawal, M.-A., Tummala, K. S., Torres-Ruiz, R., Rodríguez, S., Perna, C., & Djouder, N. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.11.006 · Cited by 53
LKB1 Represses ATOH1 via PDK4 and Energy Metabolism and Regulates Intestinal Stem Cell Fate
Gao, Y., Yan, Y., Tripathi, S., Pentinmikko, N., Amaral, A. I., Päivinen, P., Domènech‐Moreno, E., Andersson, S., Wong, I. P. L., Clevers, H. C., et al. (2020) · Gastroenterology · doi:10.1053/j.gastro.2019.12.033 · Cited by 52
Self-citationEnzymology of extracellular NAD metabolism
Gasparrini, M., Sorci, L., & Raffaelli, N. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03742-1 · Cited by 55
Mitochondrial regulation in stem cells
Wang, Y., Barthez, M., & Chen, D. (2023) · Trends in Cell Biology · doi:10.1016/j.tcb.2023.10.003 · Cited by 56
Nutrient availability links mitochondria, apoptosis, and obesity
Pintus, F., Floris, G., & Rufini, A. (2012) · Aging · doi:10.18632/aging.100505 · Cited by 51
Intermittent Fasting: Physiological Implications on Outcomes in Mice and Men
Lee, J. H., Verma, N., Thakkar, N., Yeung, C., & Sung, H. (2020) · Physiology · doi:10.1152/physiol.00030.2019 · Cited by 55
Urbauer, E., Rath, E., & Haller, D. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.602814 · Cited by 55
Lipid and glucose metabolism in senescence
Liu, B., Meng, Q., Gao, X., Sun, H., Xu, Z., Wang, Y., & Zhou, H. (2023) · Frontiers in Nutrition · doi:10.3389/fnut.2023.1157352 · Cited by 54
Gałat, A. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-1206-z · Cited by 48
Interleukin‑22 regulates the homeostasis of the intestinal epithelium during inflammation
Zhang, X., Liu, S., Wang, Y., Hu, H., Li, L., Wu, Y., Cao, D., Cai, Y., Zhang, J., & Zhang, X. (2019) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2019.4092 · Cited by 51
Attia, S. L., Feenstra, M. E., Swain, N., Cuesta, M., & Bandsma, R. (2017) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0000000000001629 · Cited by 53
Stem Cell Intrinsic Hexosamine Metabolism Regulates Intestinal Adaptation to Nutrient Content
Mattila, J., Kokki, K., Hietakangas, V., & Boutros, M. (2018) · Developmental Cell · doi:10.1016/j.devcel.2018.08.011 · Cited by 49
Bonfini, A., Dobson, A. J., Duneau, D., Revah, J., Liu, X., Houtz, P., & Buchon, N. (2021) · eLife · doi:10.7554/elife.64125 · Cited by 46
Glycolytic Regulation of Intestinal Stem Cell Self-Renewal and Differentiation
Li, C., Zhou, Y., Wei, R., Napier, D. L., Sengoku, T., Alstott, M. C., Liu, J., Wang, C., Zaytseva, Y. Y., Weiss, H. L., et al. (2022) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2022.12.012 · Cited by 53
New tricks for an old dog: ribosome biogenesis contributes to stem cell homeostasis
Brombin, A., Joly, J., & Jamen, F. (2015) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2015.07.006 · Cited by 50
mTOR signalling, embryogenesis and the control of lung development
Land, S. C., Scott, C. L., & Walker, D. J. (2014) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2014.09.023 · Cited by 50
ERα promotes murine hematopoietic regeneration through the Ire1α-mediated unfolded protein response
Chapple, R. H., Hu, T., Tseng, Y.-J., Liu, L., Kitano, A., Luu, V., Hoegenauer, K. A., Iwawaki, T., Li, Q., & Nakada, D. (2018) · eLife · doi:10.7554/elife.31159 · Cited by 54
Dietary Factors in the Control of Gut Homeostasis, Intestinal Stem Cells, and Colorectal Cancer
Francescangeli, F., Angelis, M. L. D., & Zeuner, A. (2019) · Nutrients · doi:10.3390/nu11122936 · Cited by 51
Li, S., Lu, C., Diem, E. C., Li, W., Guderian, M., Lindenberg, M., Kruse, F., Büettner, M., Floess, S., Winny, M. R., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-31725-2 · Cited by 48
The force is strong with this one: metabolism (Over)powers stem cell fate
Wei, P., Dove, K. K., Bensard, C., Schell, J. C., & Rutter, J. (2018) · Trends in Cell Biology · doi:10.1016/j.tcb.2018.02.007 · Cited by 47
Complementary intestinal mucosa and microbiota responses to caloric restriction
Duszka, K., Ellero‐Simatos, S., Ow, G. S., Defernez, M., Paramalingam, E., Tett, A., Shi, Y., König, J. S., Narbad, A., Kuznetsov, V. A., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-29815-7 · Cited by 48
von Frieling, J., Faisal, M. N., Sporn, F., Pfefferkorn, R., Nolte, S. S., Sommer, F., Rosenstiel, P. C., & Roeder, T. (2020) · PLoS Genetics · doi:10.1371/journal.pgen.1008789 · Cited by 47
Nutritional Control of Intestinal Stem Cells in Homeostasis and Tumorigenesis
Calibasi‐Kocal, G., Mashinchian, O., Başbınar, Y., Ellidokuz, E., Cheng, C., & Yilmaz, Ö. H. (2020) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2020.11.003 · Cited by 47
Self-citationSphyris, N., Hodder, M. C., & Sansom, O. J. (2021) · Cancers · doi:10.3390/cancers13051000 · Cited by 49
A single cell survey of the microbial impacts on the mouse small intestinal epithelium
Tsang, D. K. L., Wang, R. J., De, O., Ayyaz, A., Foerster, E. G., Bayer, G., Goyal, S., Trcka, D., Ghoshal, B., Wrana, J. L., et al. (2022) · Gut Microbes · doi:10.1080/19490976.2022.2108281 · Cited by 46
Defining hierarchies of stemness in the intestine: evidence from biomarkers and regulatory pathways
Gracz, A. D., & Magness, S. T. (2014) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00066.2014 · Cited by 48
Type 1 Diabetes and Dysfunctional Intestinal Homeostasis
D’Addio, F., & Fiorina, P. (2016) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2016.04.005 · Cited by 48
Farhadipour, M., Arnauts, K., Clarysse, M., Thijs, T., Liszt, K. I., der Schueren, B. V., Ceulemans, L. J., Deleus, E., Lannoo, M., Ferrante, M., et al. (2023) · iScience · doi:10.1016/j.isci.2023.108517 · Cited by 47
Lipid Metabolism Greases the Stem Cell Engine
Folmes, C. D. L., Park, S., & Terzic, A. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.01.010 · Cited by 45
Intestinal renewal across the animal kingdom: comparing stem cell activity in mouse and Drosophila
Zwick, R. K., Ohlstein, B., & Klein, O. D. (2018) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00353.2018 · Cited by 44
Identifying key regulators of the intestinal stem cell niche
Duckworth, C. A. (2021) · Biochemical Society Transactions · doi:10.1042/bst20210223 · Cited by 47
Wang, G., Chen, L., Qin, S., Zhang, T., Yao, J., Yi, Y., & Deng, L. (2022) · Advances in Nutrition · doi:10.1093/advances/nmac055 · Cited by 45
Remodelling of the intestinal ecosystem during caloric restriction and fasting
Ducarmon, Q. R., Grundler, F., Maho, Y. L., de Toledo, F. W., Zeller, G., Habold, C., & Mesnage, R. (2023) · Trends in Microbiology · doi:10.1016/j.tim.2023.02.009 · Cited by 51
Chagin, A. S., & Newton, P. T. (2019) · Pediatric Research · doi:10.1038/s41390-019-0722-z · Cited by 45
Bayer, F., Dremova, O., Khuu, M. P., Mammadova, K., Pontarollo, G., Kiouptsi, K., Soshnikova, N. V., May‐Simera, H., Endres, K., & Reinhardt, C. (2021) · Nutrients · doi:10.3390/nu13072198 · Cited by 47
Dietary and metabolic effects on intestinal stem cells in health and disease
Shay, J. E. S., & Yilmaz, Ö. H. (2024) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-024-00980-7 · Cited by 47
Self-citationShushimita, S., de Bruijn, M. J. W., de Bruin, R. W. F., IJzermans, J. N. M., Hendriks, R. W., & Dor, F. J. M. F. (2014) · PLoS ONE · doi:10.1371/journal.pone.0087772 · Cited by 43
Ling, C., Versloot, C. J., Kvissberg, M. E. A., Hu, G., Swain, N., Horcas‐Nieto, J. M., Miraglia, E., Thind, M. K., Farooqui, A., Gerding, A., et al. (2023) · EBioMedicine · doi:10.1016/j.ebiom.2023.104809 · Cited by 43
Influence of Growth Hormone and Glutamine on Intestinal Stem Cells: A Narrative Review
Chen, Y., Tsai, Y., Tseng, B.-J., & Tseng, S. (2019) · Nutrients · doi:10.3390/nu11081941 · Cited by 42
Restoring aged stem cell functionality: Current progress and future directions
Spehar, K., Pan, A., & Beerman, I. (2020) · Stem Cells · doi:10.1002/stem.3234 · Cited by 46
Short Bowel Syndrome: A Paradigm for Intestinal Adaptation to Nutrition?
Beyec, J. L., Billiauws, L., Bado, A., Joly, F., & Gall, M. L. (2020) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-011720-122203 · Cited by 42
Hou, Q., Dong, Y., Huang, J., Liao, C., Lei, J., Wang, Y., Lai, Y., Bian, Y., He, Y., Sun, J., et al. (2020) · Communications Biology · doi:10.1038/s42003-020-01347-9 · Cited by 42
Immunosenescence: a product of the environment?
Su, D.-M., Aw, D., & Palmer, D. B. (2013) · Current Opinion in Immunology · doi:10.1016/j.coi.2013.05.018 · Cited by 41
Melnik, B. C. (2021) · Biomolecules · doi:10.3390/biom11030404 · Cited by 47
Bischof, E. Y., Siow, R. C. M., Zhavoronkov, A. A., & Kaeberlein, M. R. (2021) · The Lancet Healthy Longevity · doi:10.1016/s2666-7568(20)30068-4 · Cited by 40
Enteroendocrine cells regulate intestinal homeostasis and epithelial function
Nwako, J. G., & McCauley, H. A. (2024) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2024.112339 · Cited by 49
Intermittent fasting triggers interorgan communication to suppress hair follicle regeneration
Chen, H., Liu, C., Cui, S., Xia, Y., Zhang, K., Cheng, H., Peng, J., Yu, X., Li, L., Yu, H., et al. (2024) · Cell · doi:10.1016/j.cell.2024.11.004 · Cited by 41
The ADP-ribosyl cyclases - the current evolutionary state of the ARCs
Enza, M. F. (2014) · Frontiers in bioscience · doi:10.2741/4262 · Cited by 40
Filippello, A., Mauro, S. D., Scamporrino, A., Malaguarnera, R., Torrisi, S. A., Leggio, G. M., Pino, A. D., Scicali, R., Purrello, F., & Piro, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22136660 · Cited by 40
Cdk5rap3 is essential for intestinal Paneth cell development and maintenance
Quintero, M. K., Liu, S. M., Xia, Y., Huang, Y., Zou, Y., Li, G., Hu, L., Singh, N., Blumberg, R. S., Cai, Y., et al. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-03401-8 · Cited by 39
Yang, Z., Dong, P., Fu, X., Li, Q., Ma, S., Wu, D., Kang, N., Liu, X., Li, Y., & Xiao, R. (2015) · Stem Cells · doi:10.1002/stem.2063 · Cited by 40
Calorie restriction and NAD+/sirtuin counteract the hallmarks of aging
Michán, S. (2014) · Frontiers in bioscience · doi:10.2741/4283 · Cited by 40
Is Rapamycin a Dietary Restriction Mimetic?
Unnikrishnan, A., Kurup, K., Salmon, A. B., & Richardson, A. G. (2019) · The Journals of Gerontology Series A · doi:10.1093/gerona/glz060 · Cited by 37
Liang, S., Guo, X.-K., Ou, J., Huang, R., Xue, Q., Zhang, B., Chung, Y., Wu, W., Dong, C., Yang, X., et al. (2019) · Cell Host & Microbe · doi:10.1016/j.chom.2019.03.012 · Cited by 40
IFN-γ mediates Paneth cell death via suppression of mTOR
Araujo, A. M., Safronova, A., Burger, E., López-Yglesias, A. H., Giri, S., Camanzo, E., Martin, A. T., Grivennikov, S. I., & Yarovinsky, F. (2021) · eLife · doi:10.7554/elife.60478 · Cited by 41
Metadata
- Authors
- Yilmaz, Ö. H., Katajisto, P., Lamming, D. W., Gültekin, Y., Bauer-Rowe, K. E., Sengupta, S., Birsoy, K., Dursun, A., Yilmaz, V. O., Selig, M., Nielsen, G. P., Mino-Kenudson, M., Zukerberg, L. R., Bhan, A. K., Deshpande, V., & Sabatini, D. M.
- Affiliations
- Harvard University (US)
- Broad Institute (US)
- Corresponding author
- Sabatini, David M.
- ORCID
- Venue
- Nature
- Published
- 2012-05-20
- Volume
- 486
- Issue
- 7404
- Pages
- 490-495
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC3387287
- OpenAlex
- W2113486346
- Cited by
- 753
- References
- 33
- Citations by year
- 2026: 38 · 2025: 45 · 2024: 44 · 2023: 58 · 2022: 53 · 2021: 75 · 2020: 69 · 2019: 54 · 2018: 63 · 2017: 56 · 2016: 39 · 2015: 39 · 2014: 52 · 2013: 47 · 2012: 19
- FWCI
- 20.17
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
- RePEc: Research Papers in Economics (submittedVersion)
- DSpace@MIT (Massachusetts Institute of Technology) (submittedVersion, cc-by-nc)
- Funders
- Howard Hughes Medical Institute
- National Institute on Aging (F32AG032833)
- National Cancer Institute (T32CA09216, CA129105, CA103866, R01CA103866, R01CA129105, T32CA009216)
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK043351)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Keywords
- mTORC1, Paneth cells, intestinal stem cells, intestinal stem cell niche, caloric restriction, BST1, cyclic ADP-ribose, paracrine signaling, stem cell self-renewal, intestinal regeneration, nutritional status, rapamycin, lifespan
- MeSH terms
- Mechanistic Target of Rapamycin Complex 1, Animals, Energy Intake, Cell Count, Cell Division, Female, Intestines, Longevity, Male, Proteins, Regeneration, Stem Cells, Signal Transduction, Antigens, CD, Paneth Cells, Paracrine Communication, Sirolimus, Caloric Restriction, ADP-ribosyl Cyclase, Cyclic ADP-Ribose, Multiprotein Complexes, Mice, Stem Cell Niche, TOR Serine-Threonine Kinases, GPI-Linked Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
