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Translation of Cellular Senescence to Novel Therapeutics: Insights From Alternative Tools and Models

Inci, Nurcan, Kamali, Dilanur, Akyildiz, Erdogan Oguzhan, Tahir Turanli, Eda, Bozaykut, Perinur·2022·Frontiers in Aging
DOI 10.3389/fragi.2022.828058PMC PMC9261353
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Abstract

Increasing chronological age is the greatest risk factor for human diseases. Cellular senescence (CS), which is characterized by permanent cell-cycle arrest, has recently emerged as a fundamental mechanism in developing aging-related pathologies. During the aging process, senescent cell accumulation results in senescence-associated secretory phenotype (SASP) which plays an essential role in tissue dysfunction. Although discovered very recently, senotherapeutic drugs have been already involved in clinical studies. This review gives a summary of the molecular mechanisms of CS and its role particularly in the development of cardiovascular diseases (CVD) as the leading cause of death. In addition, it addresses alternative research tools including the nonhuman and human models as well as computational techniques for the discovery of novel therapies. Finally, senotherapeutic approaches that are mainly classified as senolytics and senomorphics are discussed.

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  • According to the antagonistic pleiotropy theory, senescence is a conserved mechanism that confers early-life benefits, notably tumor suppression and wound healing, while contributing to age-related decline later in life.

    “According to the antagonistic pleiotropy theory, senescence is a conserved mechanism that confers early-life benefits, notably tumor suppression and wound healing, while contributing to age-related decline later in life132.”

    From Emerging strategies in senotherapeutics: from broad-spectrum senolysis to precision reprogramming (2026) · cites this paper as [132]

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Research works printed but not linked: 200

  1. Adamus, 2014, P16INK4A Influences the Aging Phenotype in the Living Skin Equivalent, J. Invest. Dermatol., 134, 1131, 10.1038/jid.2013.468 · DOI
  2. Akiguchi, 2017, SAMP8 Mice as a Neuropathological Model of Accelerated Brain Aging and Dementia: Toshio Takeda's Legacy and Future Directions, Neuropathology, 37, 293, 10.1111/neup.12373 · DOI
  3. Alessio, 2021, Different Stages of Quiescence, Senescence, and Cell Stress Identified by Molecular Algorithm Based on the Expression of Ki67, Rps6, and Beta-Galactosidase Activity, Ijms, 22, 3102, 10.3390/ijms22063102 · DOI
  4. Andziak, 2006, Disparate Patterns of Age-Related Changes in Lipid Peroxidation in Long-Lived Naked Mole-Rats and Shorter-Lived Mice, Aging Cell, 5, 525, 10.1111/j.1474-9726.2006.00246.x · DOI
  5. Antonioli, 2019, Individual Response to mTOR Inhibition in Delaying Replicative Senescence of Mesenchymal Stromal Cells, PLoS One, 14, e0204784, 10.1371/journal.pone.0204784 · DOI
  6. Assmus, 2003, HMG-CoA Reductase Inhibitors Reduce Senescence and Increase Proliferation of Endothelial Progenitor Cells via Regulation of Cell Cycle Regulatory Genes, Circ. Res., 92, 1049, 10.1161/01.RES.0000070067.64040.7C · DOI
  7. Avivi, 2005, Increased Blood Vessel Density Provides the Mole Rat Physiological Tolerance to its Hypoxic Subterranean Habitat, FASEB J., 19, 1314, 10.1096/fj.04-3414fje · DOI
  8. Azpurua, 2012, Long-Lived Cancer-Resistant Rodents as New Model Species for Cancer Research, Front. Gene, 3, 319, 10.3389/fgene.2012.00319 · DOI
  9. Balistreri, 2021, Is it the Time of Seno-Therapeutics Application in Cardiovascular Pathological Conditions Related to Ageing?, Curr. Res. Pharmacol. Drug Discov., 2, 100027, 10.1016/J.CRPHAR.2021.100027 · DOI
  10. Barkauskas, 2017, Lung Organoids: Current Uses and Future Promise, Dev., 144, 986, 10.1242/dev.140103 · DOI
  11. Barouch, 2006, Cardiac Myocyte Apoptosis Is Associated with Increased DNA Damage and Decreased Survival in Murine Models of Obesity, Circ. Res., 98, 119, 10.1161/01.RES.0000199348.10580.1D · DOI · Paper page
  12. Barros, 2021, Vascular Aging in Rodent Models: Contrasting Mechanisms Driving the Female and Male Vascular Senescence, Front. Aging, 2, 1, 10.3389/fragi.2021.727604 · DOI
  13. Basatemur, 2019, Vascular Smooth Muscle Cells in Atherosclerosis, Nat. Rev. Cardiol., 16, 727, 10.1038/s41569-019-0227-9 · DOI · Paper page
  14. Baumann, 2016, Senescence and Reprogramming Go Hand-In-Hand, Nat. Rev. Mol. Cel. Biol., 18, 4, 10.1038/nrm.2016.165 · DOI · Paper page
  15. Benjamin, 2019, Heart Disease and Stroke Statistics-2019 Update: A Report from the American Heart Association, Circulation, 139, e56, 10.1161/CIR.0000000000000659 · DOI · Paper page
  16. Bennett, 2016, New Tools for Studying Microglia in the Mouse and Human CNS, Proc. Natl. Acad. Sci. U.S.A., 113, E1738, 10.1073/pnas.1525528113 · DOI · Paper page
  17. Bergmann, 2009, Evidence for Cardiomyocyte Renewal in Humans, Science, 324, 98, 10.1126/science.1164680 · DOI · Paper page
  18. Bergmann, 2015, Dynamics of Cell Generation and Turnover in the Human Heart, Cell, 161, 1566, 10.1016/J.CELL.2015.05.026 · DOI
  19. Blagosklonny, 2013, Aging Is Not Programmed, Cell Cycle, 12, 3736, 10.4161/cc.27188 · DOI
  20. Bock, 2021, The Organoid Cell Atlas, Nat. Biotechnol., 39, 10.1038/s41587-020-00762-x · DOI · Paper page
  21. Bodnar, 1998, Extension of Life-Span by Introduction of Telomerase into Normal Human Cells, Science, 279, 349, 10.1126/science.279.5349.349 · DOI · Paper page
  22. Boe, 2013, Plasminogen Activator Inhibitor-1 Antagonist TM5441 Attenuates Nω -Nitro- L-Arginine Methyl Ester-Induced Hypertension and Vascular Senescence, Circulation, 128, 2318, 10.1161/CIRCULATIONAHA.113.003192 · DOI
  23. Bozaykut, 2019, Aging and Cardiovascular Diseases: The Role of Cellular Senescence, 207, 10.1007/978-981-13-8273-4_10 · DOI
  24. Bozaykut, 2021, Cellular Stress Responses of Long-Lived and Cancer-Resistant Naked Mole-Rats, Turkish J. Biochem., 46, 205, 10.1515/tjb-2020-0480 · DOI
  25. Bozaykut, High‐Throughput Profiling Reveals Perturbation of Endoplasmic Reticulum Stress‐Related Genes in Atherosclerosis Induced by High‐Cholesterol Diet and the Protective Role of Vitamin E, BioFactors, 46, 653, 10.1002/BIOF.1635 · DOI
  26. Bozaykut, HSP70 Inhibition Leads to the Activation of Proteasomal System under Mild Hyperthermia Conditions in Young and Senescent Fibroblasts, Oxidative Med. Cell Longevity, 2020, 1, 10.1155/2020/9369524 · DOI
  27. Buffenstein, 2008, Negligible Senescence in the Longest Living Rodent, the Naked Mole-Rat: Insights from a Successfully Aging Species, J. Comp. Physiol. B, 178, 439, 10.1007/s00360-007-0237-5 · DOI · Paper page
  28. Cafueri, 2012, Endothelial and Smooth Muscle Cells from Abdominal Aortic Aneurysm Have Increased Oxidative Stress and Telomere Attrition, PLOS ONE, 7, e35312, 10.1371/journal.pone.0035312 · DOI
  29. Calcinotto, 2019, Cellular Senescence: Aging, Cancer, and Injury, Physiol. Rev., 99, 1047, 10.1152/physrev.00020.2018 · DOI · Paper page
  30. Calvert, 2011, Leukocyte Telomere Length Is Associated with High-Risk Plaques on Virtual Histology Intravascular Ultrasound and Increased Proinflammatory Activity, Atvb, 31, 2157, 10.1161/ATVBAHA.111.229237 · DOI
  31. Camozzi, 2014, Diverse Lamin-dependent Mechanisms Interact to Control Chromatin Dynamics, Nucleus, 5, 427, 10.4161/nucl.36289 · DOI
  32. Campisi, 2018, Cellular Senescence, Aging, and Cancer, Innov. Aging, 2, 798, 10.1093/geroni/igy023.2963 · DOI
  33. Campisi, 2007, Cellular Senescence: when Bad Things Happen to Good Cells, Nat. Rev. Mol. Cel Biol., 8, 729, 10.1038/nrm2233 · DOI · Paper page
  34. Cánepa, 2007, INK4 Proteins, a Family of Mammalian CDK Inhibitors with Novel Biological Functions, Tbmb, 59, 419, 10.1080/15216540701488358 · DOI
  35. Cevenini, 2008, Human Models of Aging and Longevity, Expert Opin. Biol. Ther., 8, 1393, 10.1517/14712598.8.9.1393 · DOI
  36. Chen, 2018, Senescence Chips for Ultrahigh-Throughput Isolation and Removal of Senescent Cells, Aging Cell, 17, e12722, 10.1111/acel.12722 · DOI
  37. Chien, 2011, Control of the Senescence-Associated Secretory Phenotype by NF-Κb Promotes Senescence and Enhances Chemosensitivity, Genes Dev., 25, 2125, 10.1101/GAD.17276711 · DOI · Paper page
  38. Childs, 2016, Senescent Intimal Foam Cells Are Deleterious at All Stages of Atherosclerosis, Science, 354, 472, 10.1126/SCIENCE.AAF6659 · DOI · Paper page
  39. Childs, 2015, Cellular Senescence in Aging and Age-Related Disease: From Mechanisms to Therapy, Nat. Med., 21, 1424, 10.1038/nm.4000 · DOI · Paper page
  40. Chimenti, 2003, Senescence and Death of Primitive Cells and Myocytes Lead to Premature Cardiac Aging and Heart Failure, Circ. Res., 93, 604, 10.1161/01.RES.0000093985.76901.AF · DOI · Paper page
  41. Cianflone, 2020, Targeting Cardiac Stem Cell Senescence to Treat Cardiac Aging and Disease, Cells, 9, 1558, 10.3390/cells9061558 · DOI
  42. Cudejko, 2011, p16INK4a Deficiency Promotes IL-4-Induced Polarization and Inhibits Proinflammatory Signaling in Macrophages, Blood, 118, 2556, 10.1182/BLOOD-2010-10-313106 · DOI
  43. da Costa, 2016, A Synopsis on Aging-Theories, Mechanisms and Future Prospects, Ageing Res. Rev., 29, 90, 10.1016/j.arr.2016.06.005 · DOI
  44. Di Leonardo, 1994, DNA Damage Triggers a Prolonged P53-Dependent G1 Arrest and Long-Term Induction of Cip1 in Normal Human Fibroblasts, Genes Dev., 8, 2540, 10.1101/gad.8.21.2540 · DOI · Paper page
  45. Diekmann, 2016, A Three-Dimensional Skin Equivalent Reflecting Some Aspects Ofin Vivoaged Skin, Exp. Dermatol., 25, 56, 10.1111/exd.12866 · DOI
  46. Domankevich, 2018, Resistance to DNA Damage and Enhanced DNA Repair Capacity in the Hypoxia-Tolerant Blind Mole Rat Spalax Carmeli, J. Exp. Biol., 221, 10.1242/JEB.174540 · DOI
  47. Dzal, 2015, Oxygen in Demand: How Oxygen Has Shaped Vertebrate Physiology, Comp. Biochem. Physiol. A: Mol. Integr. Physiol., 186, 4, 10.1016/j.cbpa.2014.10.029 · DOI
  48. Edrey, 2012, Sustained High Levels of Neuregulin-1 in the Longest-Lived Rodents; A Key Determinant of Rodent Longevity, Aging Cell, 11, 213, 10.1111/j.1474-9726.2011.00772.x · DOI
  49. Edrey, 2011, Successful Aging and Sustained Good Health in the Naked Mole Rat: A Long-Lived Mammalian Model for Biogerontology and Biomedical Research, ILAR J., 52, 41, 10.1093/ilar.52.1.41 · DOI
  50. Eijkelenboom, 2013, FOXOs: Signalling Integrators for Homeostasis Maintenance, Nat. Rev. Mol. Cel. Biol., 14, 83, 10.1038/nrm3507 · DOI
  51. Ellison-Hughes, 2020, First Evidence that Senolytics Are Effective at Decreasing Senescent Cells in Humans, EBioMedicine, 56, 102473, 10.1016/j.ebiom.2019.09.053 · DOI
  52. Engeland, 20172018, Cell Cycle Arrest through Indirect Transcriptional Repression by P53: I Have a DREAM, Cell Death Differ., 25, 114, 10.1038/cdd.2017.172 · DOI
  53. Faulkes, 2019, Cardiac Metabolomic Profile of the Naked Mole-Rat-Glycogen to the Rescue, Biol. Lett., 15, 20190710, 10.1098/rsbl.2019.0710 · DOI
  54. Fischer, 2017, Cell Cycle Transcription Control: DREAM/MuvB and RB-E2f Complexes, Crit. Rev. Biochem. Mol. Biol., 52, 638, 10.1080/10409238.2017.1360836 · DOI · Paper page
  55. Florido, 2011, Aging and Adipose Tissue, 119, 10.1016/B978-0-12-378638-8.00005-1 · DOI
  56. Foo, 2019, Premature Aging Syndromes: From Patients to Mechanism, J. Dermatol. Sci., 96, 58, 10.1016/j.jdermsci.2019.10.003 · DOI
  57. Fuhrmann-Stroissnigg, 2017, Identification of HSP90 Inhibitors as a Novel Class of Senolytics, Nat. Commun., 8, 10.1038/s41467-017-00314-z · DOI · Paper page
  58. Funk, 1997, Inhibition of CDK Activity and PCNA-Dependent DNA Replication by P21 Is Blocked by Interaction with the HPV-16 E7 Oncoprotein, Genes Dev., 11, 2090, 10.1101/gad.11.16.2090 · DOI
  59. Galluzzi, 2018, Molecular Mechanisms of Cell Death: Recommendations of the Nomenclature Committee on Cell Death 2018, Cel. Death Differ., 25, 486, 10.1038/s41418-017-0012-4 · DOI · Paper page
  60. Galvis, 2019, A Dynamical Systems Model for the Measurement of Cellular Senescence, J. R. Soc. Interf., 16, 20190311, 10.1098/rsif.2019.0311 · DOI
  61. Giaimo, 2012, Is Cellular Senescence an Example of Antagonistic Pleiotropy?, Aging Cell, 11, 378, 10.1111/J.1474-9726.2012.00807.X · DOI
  62. Gire, 2014, Genomic Surveillance Elucidates Ebola Virus Origin and Transmission During the 2014 Outbreak, Science, 345, 1369, 10.1126/science.1259657 · DOI
  63. Gire, 2015, Senescence from G2 Arrest, Revisited, Cell Cycle, 14, 297, 10.1080/15384101.2014.1000134 · DOI · Paper page
  64. Goodrich, 1991, The Retinoblastoma Gene Product Regulates Progression Through the G1 Phase of the Cell Cycle, Cell, 67, 293, 10.1016/0092-8674(91)90181-w · DOI
  65. Gorbunova, 2012, Cancer Resistance in the Blind Mole Rat Is Mediated by Concerted Necrotic Cell Death Mechanism, Proc. Natl. Acad. Sci. U.S.A., 109, 19392, 10.1073/pnas.1217211109 · DOI
  66. Grimes, 2012, Getting to the Heart of the Matter: Age-Related Changes in Diastolic Heart Function in the Longest-Lived Rodent, the Naked Mole Rat, Journals Gerontol. Ser. A: Biol. Sci. Med. Sci., 384, 10.1093/gerona/glr222 · DOI
  67. Grimes, 2014, And the Beat Goes on: Maintained Cardiovascular Function During Aging in the Longest-Lived Rodent, the Naked Mole-Rat, Am. J. Physiology-Heart Circulatory Physiol., 307, H284, 10.1152/ajpheart.00305.2014 · DOI
  68. Grootaert, 2021, Vascular Smooth Muscle Cells in Atherosclerosis: Time for a Re-Assessment, Cardiovasc. Res., 117, 2326, 10.1093/cvr/cvab046 · DOI
  69. Guiley, 2015, Structural Mechanisms of DREAM Complex Assembly and Regulation, Genes Dev., 29, 961, 10.1101/GAD.257568.114 · DOI
  70. Hamczyk, Aging in the Cardiovascular System: Lessons from Hutchinson-Gilford Progeria Syndrome, Annu. Rev. Physiol., 80, 27, 10.1146/annurev-physiol-021317-121454 · DOI
  71. Hamczyk, Vascular Smooth Muscle-Specific Progerin Expression Accelerates Atherosclerosis and Death in a Mouse Model of Hutchinson-Gilford Progeria Syndrome, Circulation, 138, 266, 10.1161/CIRCULATIONAHA.117.030856 · DOI · Paper page
  72. Han, 2018, β-Hydroxybutyrate Prevents Vascular Senescence Through hnRNP A1-Mediated Upregulation of Oct4, Mol. Cel., 71, 1064, 10.1016/j.molcel.2018.07.036 · DOI
  73. Harley, 1990, Telomeres Shorten During Ageing of Human Fibroblasts, Nature, 345, 458, 10.1038/345458A0 · DOI · Paper page
  74. Hayflick, 1961, The Serial Cultivation of Human Diploid Cell Strains, Exp. Cel. Res., 25, 585, 10.1016/0014-4827(61)90192-6 · DOI · Paper page
  75. He, 2020, Gut Stem Cell Aging Is Driven by mTORC1 via a P38 MAPK-P53 Pathway, Nat. Commun., 11, 10.1038/s41467-019-13911-x · DOI
  76. He, 2017, Senescence in Health and Disease, Cell, 169, 1000, 10.1016/j.cell.2017.05.015 · DOI · Paper page
  77. Hernandez-Segura, 2018, Hallmarks of Cellular Senescence, Trends Cel. Biol., 28, 436, 10.1016/j.tcb.2018.02.001 · DOI · Paper page
  78. Hinze, 2018, Endocytosis in Proliferating, Quiescent and Terminally Differentiated Cells, J. Cel. Sci., 131, jcs216804, 10.1242/jcs.216804 · DOI
  79. Hu, 2019, Vascular Smooth Muscle Cells Contribute to Atherosclerosis Immunity, Front. Immunol., 10, 1101, 10.3389/fimmu.2019.01101 · DOI
  80. Hu, 2018, Opportunities for Organoids as New Models of Aging, J. Cel. Biol., 217, 39, 10.1083/jcb.201709054 · DOI
  81. Hubbard, 2014, Small Molecule SIRT1 Activators for the Treatment of Aging and Age-Related Diseases, Trends Pharmacol. Sci., 35, 146, 10.1016/j.tips.2013.12.004 · DOI
  82. Igarashi, 2016, mTORC1 and SIRT1 Cooperate to Foster Expansion of Gut Adult Stem Cells During Calorie Restriction, Cell, 166, 436, 10.1016/j.cell.2016.05.044 · DOI
  83. Igarashi, 2019, NAD+ Supplementation Rejuvenates Aged Gut Adult Stem Cells, Aging Cell, 18, e12935, 10.1111/acel.12935 · DOI · Paper page
  84. Imai, 2014, Crosstalk Between the Rb Pathway and AKT Signaling Forms a Quiescence-Senescence Switch, Cel. Rep., 7, 194, 10.1016/j.celrep.2014.03.006 · DOI · Paper page
  85. Jackson, 2021, Attenuating Senescence and Dead Cells Accumulation as Heart Failure Therapy: Break the Communication Networks, Int. J. Cardiol., 334, 72, 10.1016/J.IJCARD.2021.03.061 · DOI
  86. Kang, 2019, Senolytics and Senostatics: A Two-Pronged Approach to Target Cellular Senescence for Delaying Aging and Age-Related Diseases, Mol. Cell, 42, 821, 10.14348/molcells.2019.0298 · DOI
  87. Karin, 2021, Senescent Cell Accumulation Mechanisms Inferred from Parabiosis, GeroScience, 43, 329, 10.1007/s11357-020-00286-x · DOI · Paper page
  88. Kastenhuber, 2017, Putting P53 in Context, Cell, 170, 1062, 10.1016/j.cell.2017.08.028 · DOI · Paper page
  89. Katsuumi, 2018, Catecholamine-Induced Senescence of Endothelial Cells and Bone Marrow Cells Promotes Cardiac Dysfunction in Mice, Int. Heart J., 59, 837, 10.1536/IHJ.17-313 · DOI
  90. Kim, 2019, Senotherapeutics: Emerging Strategy for Healthy Aging and Age-Related Disease, BMB Rep., 52, 47, 10.5483/BMBRep.2019.52.1.293 · DOI
  91. Kirkland, 2017, Cellular Senescence: A Translational Perspective, EBioMedicine, 21, 21, 10.1016/j.ebiom.2017.04.013 · DOI · Paper page
  92. Kirkwood, 2015, Deciphering Death: a Commentary on Gompertz (1825) ‘On the Nature of the Function Expressive of the Law of Human Mortality, and on a New Mode of Determining the Value of Life Contingencies', Phil. Trans. R. Soc. B, 370, 20140379, 10.1098/rstb.2014.0379 · DOI
  93. Kirschner, 2020, Functional Heterogeneity in Senescence, Biochem. Soc. Trans., 48, 765, 10.1042/BST20190109 · DOI
  94. Kobashigawa, 2019, Stress-induced Cellular Senescence Contributes to Chronic Inflammation and Cancer Progression, Therm. Med., 35, 41, 10.3191/thermalmed.35.41 · DOI · Paper page
  95. Komaravolu, 2019, ApoER2 (Apolipoprotein E Receptor-2) Deficiency Accelerates Smooth Muscle Cell Senescence via Cytokinesis Impairment and Promotes Fibrotic Neointima after Vascular Injury, Atvb, 39, 2132, 10.1161/ATVBAHA.119.313194 · DOI
  96. Korenjak, 2005, E2F-Rb Complexes Regulating Transcription of Genes Important for Differentiation and Development, Curr. Opin. Genet. Development, 15, 520, 10.1016/j.gde.2005.07.001 · DOI
  97. Kotake, 2011, Long Non-coding RNA ANRIL Is Required for the PRC2 Recruitment to and Silencing of p15INK4B Tumor Suppressor Gene, Oncogene, 30, 1956, 10.1038/onc.2010.568 · DOI · Paper page
  98. Kuilman, 2010, The Essence of Senescence: Figure 1, Genes Dev., 24, 2463, 10.1101/GAD.1971610 · DOI · Paper page
  99. Kuilman, 2008, Oncogene-Induced Senescence Relayed by an Interleukin-Dependent Inflammatory Network, Cell, 133, 1019, 10.1016/j.cell.2008.03.039 · DOI · Paper page
  100. Kumari, 2021, Mechanisms of Cellular Senescence: Cell Cycle Arrest and Senescence Associated Secretory Phenotype, Front. Cel. Dev. Biol., 9, 1, 10.3389/fcell.2021.645593 · DOI · Paper page
  101. Kuro-o, 2011, Klotho and the Aging Process, Korean J. Intern. Med., 26, 113, 10.3904/kjim.2011.26.2.113 · DOI
  102. Kyuragi, 2015, BubR1 Insufficiency Inhibits Neointimal Hyperplasia Through Impaired Vascular Smooth Muscle Cell Proliferation in Mice, Atvb, 35, 341, 10.1161/ATVBAHA.114.304737 · DOI
  103. Laberge, 2013, Mitochondrial DNA Damage Induces Apoptosis in Senescent Cells, Cell Death Dis., 4, e727, 10.1038/cddis.2013.199 · DOI · Paper page
  104. Labinskyy, 2006, Comparison of Endothelial Function, O2−· and H2O2 Production, and Vascular Oxidative Stress Resistance Between the Longest-Living Rodent, the Naked Mole Rat, and Mice, Am. J. Physiology-Heart Circulatory Physiol., 291, H2698, 10.1152/ajpheart.00534.2006 · DOI
  105. Lai, 1999, RBP1 Recruits Both Histone Deacetylase-Dependent and -Independent Repression Activities to Retinoblastoma Family Proteins, Mol. Cel. Biol., 19, 6632, 10.1128/MCB.19.10.6632 · DOI
  106. Lamming, 2013, Rapalogs and mTOR Inhibitors as Anti-Aging Therapeutics, J. Clin. Invest., 123, 980, 10.1172/JCI64099 · DOI · Paper page
  107. Lewis, 2016, The Naked Mole-Rat, 179, 10.1016/B978-0-12-411596-5.00006-X · DOI
  108. Li, 2018, The cGAS-cGAMP-STING Pathway Connects DNA Damage to Inflammation, Senescence, and Cancer, J. Exp. Med., 215, 1287, 10.1084/JEM.20180139 · DOI · Paper page
  109. Li, 2021, SIRT6 in Senescence and Aging-Related Cardiovascular Diseases, Front. Cel. Dev. Biol., 9, 1, 10.3389/fcell.2021.641315 · DOI
  110. Li, 2015, Regulation of the Cell Cycle, 165, 10.1016/B978-1-4557-4066-6.00011-1 · DOI
  111. Liu, 2020, Inflammageing in the Cardiovascular System: Mechanisms, Emerging Targets, and Novel Therapeutic Strategies, Clin. Sci., 134, 2243, 10.1042/CS20191213 · DOI
  112. Liu, 2017, Anti-Aging Implications of Astragalus Membranaceus (Huangqi): A Well-Known Chinese Tonic, Aging Dis., 8, 868, 10.14336/AD.2017.0816 · DOI
  113. Liu, 2015, Simvastatin Suppresses Breast Cancer Cell Proliferation Induced by Senescent Cells, Sci. Rep., 5, 17895, 10.1038/srep17895 · DOI · Paper page
  114. Liu, 2019, A Tale of the Good and Bad: Cell Senescence in Bone Homeostasis and Disease, Int. Rev. Cel. Mol. Biol., 346, 97, 10.1016/bs.ircmb.2019.03.005 · DOI
  115. Lopez-Soler, 2001, A Role for Nuclear Lamins in Nuclear Envelope Assembly, J. Cel. Biol., 154, 61, 10.1083/jcb.200101025 · DOI
  116. Lowe, 2004, Intrinsic Tumour Suppression, Nature, 432, 307, 10.1038/nature03098 · DOI
  117. Lozano-Torres, 2019, The Chemistry of Senescence, Nat. Rev. Chem., 3, 426, 10.1038/s41570-019-0108-0 · DOI · Paper page
  118. Manov, 2013, Pronounced Cancer Resistance in a Subterranean Rodent, the Blind Mole-Rat, Spalax: In Vivo and in Vitroevidence, BMC Biol., 11, 10.1186/1741-7007-11-91 · DOI
  119. Mao, 2012, Replicatively Senescent Cells Are Arrested in G1 and G2 Phases N-Acetylcysteine Treatment Reduces Age-Related Hearing Loss and Memory Impairment in the Senescence-Accelerated Prone 8 (SAMP8) Mouse Model, Agingaging Dis., 49, 431, 10.18632/aging.100467.Marie10.14336/AD.2017.0930 · DOI
  120. Marie, 2018, N-Acetylcysteine Treatment Reduces Age-Related Hearing Loss and Memory Impairment in the Senescence-Accelerated Prone 8 (SAMP8) Mouse Model, Aging Dis, 9, 10.14336/AD.2017.0930 · DOI
  121. Massó, 2015, Secreted and Transmembrane αKlotho Isoforms Have Different Spatio-Temporal Profiles in the Brain During Aging and Alzheimer's Disease Progression, PLoS One, 10, e0143623, 10.1371/journal.pone.0143623 · DOI
  122. Matsumoto, 2007, Aging-Associated Vascular Phenotype in Mutant Mice with Low Levels of BubR1, Stroke, 38, 1050, 10.1161/01.STR.0000257967.86132.01 · DOI · Paper page
  123. McHugh, 2017, Senescence and Aging: Causes, Consequences, and Therapeutic Avenues, J. Cel. Biol., 217, 65, 10.1083/jcb.201708092 · DOI · Paper page
  124. Mendelsohn, 2018, Cellular Senescence as the Key Intermediate in Tau-Mediated Neurodegeneration, Rejuvenation Res., 21, 572, 10.1089/rej.2018.2155 · DOI
  125. Mihaylova, 2018, Fasting Activates Fatty Acid Oxidation to Enhance Intestinal Stem Cell Function During Homeostasis and Aging, Cell Stem Cell, 22, 769, 10.1016/j.stem.2018.04.001 · DOI · Paper page
  126. Minamino, 2002, Endothelial Cell Senescence in Human Atherosclerosis, Circulation, 105, 1541, 10.1161/01.CIR.0000013836.85741.17 · DOI · Paper page
  127. Moir, 2001, The Structure and Function of Nuclear Lamins: Implications for Disease, Cmls, Cel. Mol. Life Sci., 58, 1748, 10.1007/PL00000814 · DOI
  128. Mounkes, 2004, Aging and Nuclear Organization: Lamins and Progeria, Curr. Opin. Cel. Biol., 16, 322, 10.1016/j.ceb.2004.03.009 · DOI
  129. Moutsatsou, 2019, Automation in Cell and Gene Therapy Manufacturing: From Past to Future, Biotechnol. Lett., 41, 1245, 10.1007/S10529-019-02732-Z · DOI
  130. Müller, 2012, The CHR Promoter Element Controls Cell Cycle-Dependent Gene Transcription and Binds the DREAM and MMB Complexes, Nucleic Acids Res., 40, 1561, 10.1093/NAR/GKR793 · DOI
  131. Münger, 2002, Human Papillomavirus Immortalization and Transformation Functions, Virus. Res., 89, 213, 10.1016/s0168-1702(02)00190-9 · DOI
  132. Nabirotchkin, 2020, Next-Generation Drug Repurposing Using Human Genetics and Network Biology, Curr. Opin. Pharmacol., 51, 78, 10.1016/j.coph.2019.12.004 · DOI
  133. Nakamura, 2008, Both telomeric and Non-Telomeric DNA Damage Are Determinants of Mammalian Cellular Senescence, Epigenetics & Chromatin, 1, 6, 10.1186/1756-8935-1-6 · DOI · Paper page
  134. Nakamura, 2018, Autophagy and Longevity, Mol. Cell, 41, 65, 10.14348/molcells.2018.2333 · DOI
  135. Niedzielska, 2016, Oxidative Stress in Neurodegenerative Diseases, Mol. Neurobiol., 53, 4094, 10.1007/s12035-015-9337-5 · DOI · Paper page
  136. Nielsen, 2001, Rb Targets Histone H3 Methylation and HP1 to Promoters, Nature, 412, 561, 10.1038/35087620 · DOI
  137. Ock, 2016, Deletion of IGF-1 Receptors in Cardiomyocytes Attenuates Cardiac Aging in Male Mice, Endocrinology, 157, 336, 10.1210/en.2015-1709 · DOI
  138. Odeh, 2020, Downregulation of the Inflammatory Network in Senescent Fibroblasts and Aging Tissues of the Long‐Lived and Cancer‐Resistant Subterranean Wild Rodent, Spalax, Aging Cell, 19, e13045, 10.1111/acel.13045 · DOI
  139. Odile Damour, 2014, Adipose-Derived Stem Cells Promote Skin Homeostasis and Prevent its Senescence in an In Vitro Skin Model, J. Stem Cel Res Ther, 4, 10.4172/2157-7633.1000194 · DOI
  140. Okouchi, 2019, The Effect of Carbohydrate-Restricted Diets on the Skin Aging of Mice, J. Nutr. Sci. Vitaminol, 65, S67, 10.3177/jnsv.65.S67 · DOI
  141. Ortega, 2002, Cyclin Dependent Kinases, INK4 Inhibitors and Cancer, Biochim. Biophys. Acta (Bba) - Rev. Cancer, 1602, 73, 10.1016/S0304-419X(02)00037-9 · DOI
  142. Ovadya, 2018, Strategies Targeting Cellular Senescence, J. Clin. Invest., 128, 1247, 10.1172/JCI95149 · DOI · Paper page
  143. Paoli, 2014, Ketogenic Diet in Neuromuscular and Neurodegenerative Diseases, Biomed. Res. Int., 2014, 1, 10.1155/2014/474296 · DOI
  144. Pauty, 2021, A 3D Tissue Model-On-A-Chip for Studying the Effects of Human Senescent Fibroblasts on Blood Vessels, Biomater. Sci., 9, 199, 10.1039/d0bm01297a · DOI
  145. Pentinmikko, 2019, Notum Produced by Paneth Cells Attenuates Regeneration of Aged Intestinal Epithelium, Nature, 571, 398, 10.1038/s41586-019-1383-0 · DOI · Paper page
  146. Pinto, 2010, Lack of Sexual Dimorphism in Femora of the Eusocial and Hypogonadic Naked Mole-Rat: A Novel Animal Model for the Study of Delayed Puberty on the Skeletal System, Bone, 46, 112, 10.1016/j.bone.2009.08.060 · DOI
  147. Prata, 2018, Senescent Cell Clearance by the Immune System: Emerging Therapeutic Opportunities, Semin. Immunol., 40, 101275, 10.1016/j.smim.2019.04.003 · DOI · Paper page
  148. Prokocimer, 2013, Hutchinson-Gilford Progeria Syndrome Through the Lens of Transcription, Aging Cell, 12, 533, 10.1111/acel.12070 · DOI
  149. Puente, 2014, The Oxygen-Rich Postnatal Environment Induces Cardiomyocyte Cell-Cycle Arrest Through DNA Damage Response, Cell, 157, 565, 10.1016/J.CELL.2014.03.032 · DOI
  150. Pushpakom, 2019, Drug Repurposing: Progress, Challenges and Recommendations, Nat. Rev. Drug Discov., 18, 41, 10.1038/nrd.2018.168 · DOI · Paper page
  151. Regnault, 2021, Cell Senescence: Basic Mechanisms and the Need for Computational Networks in Vascular Ageing, Cardiovasc. Res., 117, 1841, 10.1093/CVR/CVAA318 · DOI
  152. Ribas, 2017, Biomechanical Strain Exacerbates Inflammation on a Progeria-on-a-Chip Model, Small, 13, 1603737, 10.1002/SMLL.201603737 · DOI
  153. Rodgers, 2019, Cardiovascular Risks Associated with Gender and Aging, Jcdd, 6, 19, 10.3390/jcdd6020019 · DOI
  154. Rodrigues, 2021, Hallmarks of Aging and Immunosenescence: Connecting the Dots, Cytokine Growth Factor. Rev., 59, 9, 10.1016/j.cytogfr.2021.01.006 · DOI
  155. Roos, 2016, Chronic Senolytic Treatment Alleviates Established Vasomotor Dysfunction in Aged or Atherosclerotic Mice, Aging Cell, 15, 973, 10.1111/acel.12458 · DOI · Paper page
  156. Ruby, 2018, Naked Mole-Rat Mortality Rates Defy Gompertzian Laws by Not Increasing with Age, Elife, 7, e31157, 10.7554/eLife.31157 · DOI
  157. Sadasivam, 2012, The MuvB Complex Sequentially Recruits B-Myb and FoxM1 to Promote Mitotic Gene Expression, Genes Dev., 26, 474, 10.1101/GAD.181933.111 · DOI
  158. Sano, 2007, p53-Induced Inhibition of Hif-1 Causes Cardiac Dysfunction During Pressure Overload, Nature, 446, 444, 10.1038/nature05602 · DOI
  159. Schafer, 2016, Exercise Prevents Diet-Induced Cellular Senescence in Adipose Tissue, Diabetes, 65, 1606, 10.2337/db15-0291 · DOI · Paper page
  160. Schmidt, 2017, Hypoxia Tolerance, Longevity and Cancer-Resistance in the Mole Rat Spalax - A Liver Transcriptomics Approach, Sci. Rep., 7, 10.1038/s41598-017-13905-z · DOI
  161. Sedivy, 2013, Death by Transposition - The Enemy Within?, Bioessays, 35, 1035, 10.1002/BIES.201300097 · DOI
  162. Seluanov, 2009, Hypersensitivity to Contact Inhibition Provides a Clue to Cancer Resistance of Naked Mole-Rat, Proc. Natl. Acad. Sci. U.S.A., 106, 19352, 10.1073/pnas.0905252106 · DOI
  163. Shaker, 2021, Klotho Inhibits Neuronal Senescence in Human Brain Organoids, Npj Aging Mech. Dis., 7, 18, 10.1038/s41514-021-00070-x · DOI
  164. Shams, 2005, Oxygen and Carbon Dioxide Fluctuations in Burrows of Subterranean Blind Mole Rats Indicate Tolerance to Hypoxic-Hypercapnic Stresses, Comp. Biochem. Physiol. Part A: Mol. Integr. Physiol., 142, 376, 10.1016/j.cbpa.2005.09.003 · DOI
  165. Sharpless, 2006, The Mighty Mouse: Genetically Engineered Mouse Models in Cancer Drug Development, Nat. Rev. Drug Discov., 5, 741, 10.1038/nrd2110 · DOI
  166. Sharpless, 2015, Forging a Signature of In Vivo Senescence, Nat. Rev. Cancer, 15, 397, 10.1038/nrc3960 · DOI · Paper page
  167. Shay, 1991, A Role for Both RB and P53 in the Regulation of Human Cellular Senescence*1, Exp. Cel. Res., 196, 33, 10.1016/0014-4827(91)90453-2 · DOI · Paper page
  168. Shay, 2019, Telomeres and Telomerase: Three Decades of Progress, Nat. Rev. Genet., 20, 299, 10.1038/s41576-019-0099-1 · DOI · Paper page
  169. Si, 2014, Dietary Antiaging Phytochemicals and Mechanisms Associated with Prolonged Survival, J. Nutr. Biochem., 25, 581, 10.1016/j.jnutbio.2014.02.001 · DOI
  170. Simian, 2017, Organoids: A Historical Perspective of Thinking in Three Dimensions, J. Cel. Biol., 216, 31, 10.1083/jcb.201610056 · DOI · Paper page
  171. Soto-Gamez, 2017, Therapeutic Interventions for Aging: The Case of Cellular Senescence, Drug Discov. Today, 22, 786, 10.1016/j.drudis.2017.01.004 · DOI · Paper page
  172. Stoll, 2016, Naked Mole-Rats Maintain Healthy Skeletal Muscle and Complex IV Mitochondrial Enzyme Function into Old Age, Aging, 8, 3468, 10.18632/aging.101140 · DOI
  173. Stoneman, 2007, Monocyte/macrophage Suppression in CD11b Diphtheria Toxin Receptor Transgenic Mice Differentially Affects Atherogenesis and Established Plaques, Circ. Res., 100, 884, 10.1161/01.RES.0000260802.75766.00 · DOI · Paper page
  174. Storer, 2013, Senescence Is a Developmental Mechanism that Contributes to Embryonic Growth and Patterning, Cell, 155, 1119, 10.1016/j.cell.2013.10.041 · DOI · Paper page
  175. Sung, 2020, SRT1720‐Induced Activation of SIRT1 Alleviates Vascular Smooth Muscle Cell Senescence Through PKA‐Dependent Phosphorylation of AMPKα at Ser485, FEBS Open Bio, 10, 1316, 10.1002/2211-5463.12895 · DOI
  176. Suram, 2012, Oncogene-Induced Telomere Dysfunction Enforces Cellular Senescence in Human Cancer Precursor Lesions, EMBO J., 31, 2839, 10.1038/emboj.2012.132 · DOI · Paper page
  177. Tacutu, 2011, Molecular Links Between Cellular Senescence, Longevity and Age-Related Diseases - A Systems Biology Perspective, Aging, 3, 1178, 10.18632/aging.100413 · DOI
  178. Takahashi, 2007, Irreversibility of Cellular Senescence: Dual Roles of p16INK4a/Rb-Pathway in Cell Cycle Control, Cell Div, 2, 10.1186/1747-1028-2-10 · DOI
  179. Tang, 2020, Cardiomyocyte Senescence and Cellular Communications within Myocardial Microenvironments, Front. Endocrinol., 11, 280, 10.3389/fendo.2020.00280 · DOI
  180. Taylor, 20132013, Statins for the Primary Prevention of Cardiovascular Disease, Cochrane Database Syst. Rev., 2021, CD004816, 10.1002/14651858.CD004816.pub5 · DOI · Paper page
  181. Torrens-Mas, 2021, Organoids: An Emerging Tool to Study Aging Signature Across Human Tissues. Modeling Aging with Patient-Derived Organoids, Ijms, 22, 10547, 10.3390/ijms221910547 · DOI
  182. Tuttle, 2020, Cellular Senescence and Chronological Age in Various Human Tissues: A Systematic Review and Meta‐Analysis, Aging Cell, 19, 1, 10.1111/acel.13083 · DOI · Paper page
  183. Uchida, 2018, Epigenetic Silencing of Lgr5 Induces Senescence of Intestinal Epithelial Organoids During the Process of Aging, Npj Aging Mech. Dis., 4, 10.1038/s41514-018-0031-5 · DOI
  184. van Deursen, 2019, Senolytic Therapies for Healthy Longevity, Science, 364, 636, 10.1126/science.aaw1299 · DOI · Paper page
  185. Vandel, 2001, Transcriptional Repression by the Retinoblastoma Protein Through the Recruitment of a Histone Methyltransferase, Mol. Cel. Biol., 21, 6484, 10.1128/MCB.21.19.6484-6494.2001 · DOI
  186. Villa-Bellosta, 2013, Defective Extracellular Pyrophosphate Metabolism Promotes Vascular Calcification in a Mouse Model of Hutchinson-Gilford Progeria Syndrome that Is Ameliorated on Pyrophosphate Treatment, Circulation, 127, 2442, 10.1161/CIRCULATIONAHA.112.000571 · DOI
  187. Virani, 2020, Heart Disease and Stroke Statistics-2020 Update: A Report from the American Heart Association, Circulation, 141, 10.1161/CIR.0000000000000757 · DOI · Paper page
  188. Wei, 2014, Vascular Smooth Muscle Cell Culture in Microfluidic Devices, Biomicrofluidics, 46504, 1, 10.1063/1.4893914 · DOI
  189. Westhoff, 2008, Hypertension Induces Somatic Cellular Senescence in Rats and Humans by Induction of Cell Cycle Inhibitor P16 INK4a, Hypertension, 52, 123, 10.1161/HYPERTENSIONAHA.107.099432 · DOI · Paper page
  190. Wijshake, 2012, Reduced Life- and Healthspan in Mice Carrying a Mono-Allelic BubR1 MVA Mutation, PLOS Genet., 8, e1003138, 10.1371/JOURNAL.PGEN.1003138 · DOI
  191. Wu, 1995, In Vivo Association of E2F and DP Family Proteins, Mol. Cel. Biol., 15, 2536, 10.1128/MCB.15.5.2536 · DOI
  192. Wu, 2020, Organ-on-a-Chip: Recent Breakthroughs and Future Prospects, Biomed. Eng. Online, 19, 1, 10.1186/s12938-020-0752-0 · DOI
  193. Xu, 2020, SIRT1 Is Downregulated by Autophagy in Senescence and Ageing, Nat. Cel. Biol., 22, 1170, 10.1038/s41556-020-00579-5 · DOI
  194. Yanai, 2018, The Role of Cellular Senescence in Aging Through the Prism of Koch-Like Criteria, Ageing Res. Rev., 41, 18, 10.1016/j.arr.2017.10.004 · DOI · Paper page
  195. Yang, 2008, Cyclin-Dependent Kinase Inhibitor p16INK4a and Telomerase May Co-Modulate Endothelial Progenitor Cells Senescence, Ageing Res. Rev., 7, 137, 10.1016/J.ARR.2008.02.001 · DOI
  196. Yu, 2002, Regulation of APC-Cdc20 by the Spindle Checkpoint, Curr. Opin. Cel. Biol., 14, 706, 10.1016/S0955-0674(02)00382-4 · DOI
  197. Yu, 2017, Chimeric Antigen Receptor T Cells: A Novel Therapy for Solid Tumors, J. Hematol. Oncol., 10, 1, 10.1186/S13045-017-0444-9 · DOI
  198. Zhang, 2000, Exit from G1 and S Phase of the Cell Cycle Is Regulated by Repressor Complexes Containing HDAC-Rb-hSWI/SNF and Rb-hSWI/SNF, Cell, 101, 79, 10.1016/S0092-8674(00)80625-X · DOI · Paper page
  199. Zhao, 2021, Transposon-Triggered Innate Immune Response Confers Cancer Resistance to the Blind Mole Rat, Nat. Immunol., 22, 1219, 10.1038/S41590-021-01027-8 · DOI · Paper page
  200. Zhao, 2018, Naked Mole Rats Can Undergo Developmental, Oncogene-Induced and DNA Damage-Induced Cellular Senescence, PNAS, 115, 1801, 10.1073/pnas.1721160115 · DOI

Cited by

Sorted by citations

Metadata

Authors
Inci, N., Kamali, D., Akyildiz, E. O., Tahir Turanli, E., & Bozaykut, P.
Venue
Frontiers in Aging
Publisher
Frontiers Media SA
Published
2022-06-01
Volume
3
ISSN
2673-6217
DOI
10.3389/fragi.2022.828058
PMC
PMC9261353
Cited by
13
References
62
Licence
creativecommons.org/licenses/by/4.0/ (vor)

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