Signatures of mutational processes in human cancer

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Items 101–200 of 1,099

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2. The whole-genome landscape of medulloblastoma subtypes
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3. Rethinking cancer nanotheranostics
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4. Pan-cancer whole-genome analyses of metastatic solid tumours
   Priestley, Peter, Baber, Jonathan, Lolkema, Martijn P., Steeghs, Neeltje, de Bruijn, Ewart, Shale, Charles, Duyvesteyn, Korneel, Haidari, Susan, van Hoeck, Arne, Onstenk, Wendy et al. · 2019 · Nature
5. RAS-targeted therapies: is the undruggable drugged?
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6. Mutational signatures associated with tobacco smoking in human cancer
   Alexandrov, Ludmil B., Ju, Young Seok, Haase, Kerstin, Van Loo, Peter, Martincorena, Iñigo, Nik-Zainal, Serena, Totoki, Yasushi, Fujimoto, Akihiro, Nakagawa, Hidewaki, Shibata, Tatsuhiro et al. · 2016 · Science
7. Signaling Pathways in Melanogenesis
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8. HRDetect is a predictor of BRCA1 and BRCA2 deficiency based on mutational signatures
   Davies, Helen, Glodzik, Dominik, Morganella, Sandro, Yates, Lucy R, Staaf, Johan, Zou, Xueqing, Ramakrishna, Manasa, Martin, Sancha, Boyault, Sandrine, Sieuwerts, Anieta M et al. · 2017 · Nature Medicine
9. Biological and therapeutic impact of intratumor heterogeneity in cancer evolution
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10. Towards personalized, tumour-specific, therapeutic vaccines for cancer
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11. Oesophageal cancer
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12. The evolutionary history of 2,658 cancers
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13. Mutations driving CLL and their evolution in progression and relapse
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14. Advances in the development of personalized neoantigen-based therapeutic cancer vaccines
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15. Integrative molecular and clinical modeling of clinical outcomes to PD1 blockade in patients with metastatic melanoma
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16. Clock-like mutational processes in human somatic cells
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17. Scalable whole-exome sequencing of cell-free DNA reveals high concordance with metastatic tumors
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18. Clonal evolution in breast cancer revealed by single nucleus genome sequencing
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19. Co-occurring genomic alterations in non-small-cell lung cancer biology and therapy
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20. The role of BCL-2 family proteins in regulating apoptosis and cancer therapy
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21. Intratumor Heterogeneity: The Rosetta Stone of Therapy Resistance
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22. The Where, the When, and the How of Immune Monitoring for Cancer Immunotherapies in the Era of Checkpoint Inhibition
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23. Routine molecular profiling of patients with advanced non-small-cell lung cancer: results of a 1-year nationwide programme of the French Cooperative Thoracic Intergroup (IFCT)
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24. Whole-genome landscape of pancreatic neuroendocrine tumours
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25. Targeting neoantigens to augment antitumour immunity
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26. Tumor cells can follow distinct evolutionary paths to become resistant to epidermal growth factor receptor inhibition
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27. Intratumor heterogeneity in localized lung adenocarcinomas delineated by multiregion sequencing
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28. The role of PD-L1 expression as a predictive biomarker: an analysis of all US Food and Drug Administration (FDA) approvals of immune checkpoint inhibitors
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29. Potential Predictive Value of TP53 and KRAS Mutation Status for Response to PD-1 Blockade Immunotherapy in Lung Adenocarcinoma
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30. Current state of melanoma diagnosis and treatment
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31. Homologous Recombination Deficiency: Exploiting the Fundamental Vulnerability of Ovarian Cancer
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32. Combination cancer immunotherapies tailored to the tumour microenvironment
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33. Actively personalized vaccination trial for newly diagnosed glioblastoma
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34. Tissue-specific mutation accumulation in human adult stem cells during life
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35. Microsatellite Instability as a Biomarker for PD-1 Blockade
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36. Insertion-and-deletion-derived tumour-specific neoantigens and the immunogenic phenotype: a pan-cancer analysis
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37. Homologous-recombination-deficient tumours are dependent on Polθ-mediated repair
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38. Immune and genomic correlates of response to anti-PD-1 immunotherapy in glioblastoma
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39. Pan-cancer genome and transcriptome analyses of 1,699 paediatric leukaemias and solid tumours
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40. Inflammatory microenvironment remodelling by tumour cells after radiotherapy
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41. Small-cell lung cancer: what we know, what we need to know and the path forward
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42. Evolution of Neoantigen Landscape during Immune Checkpoint Blockade in Non–Small Cell Lung Cancer
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43. Integrative Analysis Identifies Four Molecular and Clinical Subsets in Uveal Melanoma
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44. Molecular subtypes of pancreatic cancer
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45. Tumor Mutational Burden and Efficacy of Nivolumab Monotherapy and in Combination with Ipilimumab in Small-Cell Lung Cancer
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46. Therapeutic T cell engineering
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47. Heterogeneity of genomic evolution and mutational profiles in multiple myeloma
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48. Patterns of somatic structural variation in human cancer genomes
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49. Therapy-related clonal hematopoiesis in patients with non-hematologic cancers is common and associated with adverse clinical outcomes
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50. Tumor Mutational Burden as a Predictive Biomarker in Solid Tumors
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51. Clinical Sequencing Defines the Genomic Landscape of Metastatic Colorectal Cancer
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52. Single-cell ChIP-seq reveals cell subpopulations defined by chromatin state
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53. Tumor Cell Biodiversity Drives Microenvironmental Reprogramming in Liver Cancer
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54. The Somatic Genomic Landscape of Chromophobe Renal Cell Carcinoma
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55. Prospective identification of neoantigen-specific lymphocytes in the peripheral blood of melanoma patients
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56. Mechanisms underlying mutational signatures in human cancers
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57. DNA Replication Stress as a Hallmark of Cancer
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58. Cumulative haploinsufficiency and triplosensitivity drive aneuploidy patterns and shape the cancer genome
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59. Non-coding recurrent mutations in chronic lymphocytic leukaemia
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60. Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity
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61. Lung adenocarcinoma promotion by air pollutants
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62. High-intensity sequencing reveals the sources of plasma circulating cell-free DNA variants
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63. The changing therapeutic landscape of head and neck cancer
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64. Impaired HLA Class I Antigen Processing and Presentation as a Mechanism of Acquired Resistance to Immune Checkpoint Inhibitors in Lung Cancer
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65. PD-L1 expression in human cancers and its association with clinical outcomes
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66. Cytosine base editor generates substantial off-target single-nucleotide variants in mouse embryos
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67. Trans-ancestry mutational landscape of hepatocellular carcinoma genomes
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68. HER kinase inhibition in patients with HER2- and HER3-mutant cancers
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69. Mechanisms underlying structural variant formation in genomic disorders
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70. Immune recognition of somatic mutations leading to complete durable regression in metastatic breast cancer
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71. The head and neck cancer immune landscape and its immunotherapeutic implications
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72. Comprehensive Analysis of Hypermutation in Human Cancer
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73. Clonal evolution of glioblastoma under therapy
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74. Pan-cancer analysis of the extent and consequences of intratumor heterogeneity
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75. The landscape of somatic mutation in normal colorectal epithelial cells
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76. A decade of clinical development of PARP inhibitors in perspective
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77. Advances in bladder cancer biology and therapy
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78. The clinical role of the TME in solid cancer
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79. Genomic Hallmarks and Structural Variation in Metastatic Prostate Cancer
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80. Integrated genomic characterization of adrenocortical carcinoma
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81. Lengthening and shortening of plasma DNA in hepatocellular carcinoma patients
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82. Tumor-Specific T Cell Dysfunction Is a Dynamic Antigen-Driven Differentiation Program Initiated Early during Tumorigenesis
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83. Cutaneous melanoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
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84. Pathogenesis of Triple-Negative Breast Cancer
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85. Genomic characterization of metastatic breast cancers
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86. Preleukemic mutations in human acute myeloid leukemia affect epigenetic regulators and persist in remission
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87. Cancer biomarkers: Emerging trends and clinical implications for personalized treatment
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88. Neoantigen vaccine: an emerging tumor immunotherapy
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89. Therapy-Induced Evolution of Human Lung Cancer Revealed by Single-Cell RNA Sequencing
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90. Whole-genome mutational landscape and characterization of noncoding and structural mutations in liver cancer
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91. Direct identification of clinically relevant neoepitopes presented on native human melanoma tissue by mass spectrometry
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92. Improving cancer immunotherapy using nanomedicines: progress, opportunities and challenges
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93. Integrating genomic features for non-invasive early lung cancer detection
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94. Clonal status of actionable driver events and the timing of mutational processes in cancer evolution
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95. The genetics of myelodysplastic syndrome: from clonal haematopoiesis to secondary leukaemia
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96. The emerging complexity of gene fusions in cancer
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97. Challenges and Opportunities for Pancreatic Cancer Immunotherapy
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98. Mechanisms and therapeutic implications of hypermutation in gliomas
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99. High-throughput epitope discovery reveals frequent recognition of neo-antigens by CD4+ T cells in human melanoma
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100. Roles for retrotransposon insertions in human disease
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