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Ultrafast endocytosis at mouse hippocampal synapses
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To sustain neurotransmission, synaptic vesicles and their associated proteins must be recycled locally at synapses. Synaptic vesicles are thought to be regenerated approximately 20 s after fusion by the assembly of clathrin scaffolds or in approximately 1 s by the reversal of fusion pores via 'kiss-and-run' endocytosis. Here we use optogenetics to stimulate cultured hippocampal neurons with a single stimulus, rapidly freeze them after fixed intervals and examine the ultrastructure using electron microscopy--'flash-and-freeze' electron microscopy. Docked vesicles fuse and collapse into the membrane within 30 ms of the stimulus. Compensatory endocytosis occurs within 50 to 100 ms at sites flanking the active zone. Invagination is blocked by inhibition of actin polymerization, and scission is blocked by inhibiting dynamin. Because intact synaptic vesicles are not recovered, this form of recycling is not compatible with kiss-and-run endocytosis; moreover, it is 200-fold faster than clathrin-mediated endocytosis. It is likely that 'ultrafast endocytosis' is specialized to restore the surface area of the membrane rapidly.
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“Several recent studies suggest that synaptic vesicle endocytosis is mediated by clathrin-independent ultrafast endocytosis at mammalian central synapses and is tightly coupled to exocytosis in time and space5–9.”
From Membrane compression by synaptic vesicle exocytosis triggers ultrafast endocytosis (2023) · cites this paper as [5]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
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“Thus, the actin ring surrounding the active zone is likely essential for ultrafast endocytosis5.”
From Membrane compression by synaptic vesicle exocytosis triggers ultrafast endocytosis (2023) · cites this paper as [5]
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“Indeed, ultrafast endocytosis initiates as fast as 20–50 ms after exocytosis and completes within 100 ms5–7.”
From Membrane compression by synaptic vesicle exocytosis triggers ultrafast endocytosis (2023) · cites this paper as [5]
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“In this pathway, endocytic invaginations always form at the edge of the active zone5–7.”
From Membrane compression by synaptic vesicle exocytosis triggers ultrafast endocytosis (2023) · cites this paper as [5]
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“Following exocytosis, synaptic vesicles are recovered through clathrin-mediated, ultrafast, bulk, or kiss-and-run endocytic pathways.”
From Molecular Physiology of the Neuronal Synapse (2026) · cites this paper as [32]
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“Ultrafast endocytosis occurs rapidly, within 50–100 milliseconds following stimulation, capturing approximately four vesicles at the very edge of the active zone [32]. This mechanism is specialized for rapidly restoring the surface area of the presynaptic membrane and is kinetically distinct from both kiss-and-run and clathrin-mediated endocytosis [33].”
From Molecular Physiology of the Neuronal Synapse (2026) · cites this paper as [32]
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In the citing paper
“Several recent studies suggest that synaptic vesicle endocytosis is mediated by clathrin-independent ultrafast endocytosis at mammalian central synapses and is tightly coupled to exocytosis in time and space5–9.”
From Membrane compression by synaptic vesicle exocytosis triggers ultrafast endocytosis (2023) · cites this paper as [5]
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“Consistent with our previous work5, treatment with DMSO (control) did not affect ultrafast endocytosis, while Latrunculin A treatment completely blocked it (Fig. 2c, d; more micrographs in Supplementary Fig. 4).”
From Membrane compression by synaptic vesicle exocytosis triggers ultrafast endocytosis (2023) · cites this paper as [5]
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“Importantly, the timing and the location of endocytic pit formation quantitatively recapitulates endocytic events observed by ultrastructural analysis5,6.”
From Membrane compression by synaptic vesicle exocytosis triggers ultrafast endocytosis (2023) · cites this paper as [5]
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“Filamentous actin (F-actin) is essential for the initiation of ultrafast endocytosis5.”
From Membrane compression by synaptic vesicle exocytosis triggers ultrafast endocytosis (2023) · cites this paper as [5]
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“When neurons are treated with Latrunculin A, which sequesters monomeric actin (G-actin) and perturbs F-actin formation12,13, ultrafast endocytosis fails completely, with no induction of membrane pit formation5.”
From Membrane compression by synaptic vesicle exocytosis triggers ultrafast endocytosis (2023) · cites this paper as [5]
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“Interestingly, ultrafast endocytosis is compensatory - the membrane area of endocytic vesicles is roughly equal to the total surface area of synaptic vesicles exocytosed5,6”
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“Kiss-and-run is a rapid mechanism that involves a transient opening of a fusion pore, allowing for neurotransmitter release without full collapse of the SV into the plasma membrane [30]. The vesicle is then rapidly retrieved, often within approximately one second [31,32].”
From Molecular Physiology of the Neuronal Synapse (2026) · cites this paper as [32]
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“Key proteins involved include clathrin itself and dynamin, which mediates the scission of the budding vesicle from the plasma membrane [32].”
From Molecular Physiology of the Neuronal Synapse (2026) · cites this paper as [32]
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Citations
Cites
Computer Visualization of Three-Dimensional Image Data Using IMOD
Kremer, J. R., Mastronarde, D. N., & McIntosh, J. R. (1996) · Journal of Structural Biology · doi:10.1006/jsbi.1996.0013 · Cited by 5,530
Molecular mechanism and physiological functions of clathrin-mediated endocytosis
McMahon, H. T., & Boucrot, E. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3151 · Cited by 2,223
Heuser, J. E., & Reese, T. S. (1973) · The Journal of Cell Biology · doi:10.1083/jcb.57.2.315 · Cited by 2,147
Germline Transmission and Tissue-Specific Expression of Transgenes Delivered by Lentiviral Vectors
Lois, C., Hong, E. J., Pease, S., Brown, E. J., & Baltimore, D. (2002) · Science · doi:10.1126/science.1067081 · Cited by 1,992
Dynasore, a Cell-Permeable Inhibitor of Dynamin
Macia, E., Ehrlich, M., Massol, R., Boucrot, E., Brunner, C., & Kirchhausen, T. (2006) · Developmental Cell · doi:10.1016/j.devcel.2006.04.002 · Cited by 1,958
TrakEM2 Software for Neural Circuit Reconstruction
Cardona, A., Saalfeld, S., Schindelin, J., Arganda‐Carreras, I., Preibisch, S., Longair, M., Tomančák, P., Hartenstein, V., & Douglas, R. J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0038011 · Cited by 1,009
Gunaydin, L. A., Yizhar, O., Berndt, A., Sohal, V. S., Deisseroth, K., & Hegemann, P. (2010) · Nature Neuroscience · doi:10.1038/nn.2495 · Cited by 757
Latrunculins: Novel Marine Toxins That Disrupt Microfilament Organization in Cultured Cells
Spector, I., Shochet, N. R., Kashman, Y., & Groweiss, A. (1983) · Science · doi:10.1126/science.6681676 · Cited by 750
Granseth, B., Odermatt, B., Royle, S. J., & Lagnado, L. (2006) · Neuron · doi:10.1016/j.neuron.2006.08.029 · Cited by 686
Varoqueaux, F., Sigler, A., Rhee, J.-S., Brose, N., Enk, C., Reim, K., & Rosenmund, C. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.122623799 · Cited by 619
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Plattner, H. (2015) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/brv.12218 · Cited by 27
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Ding, B., Tian, Y., Pan, Y., Shan, Y., Cai, M., Xu, H., Sun, Y., & Wang, H. (2015) · Nanoscale · doi:10.1039/c5nr01020a · Cited by 26
Lasič, E., Stenovec, M., Kreft, M., Robinson, P. J., & Zorec, R. (2017) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2017.06.022 · Cited by 26
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Araújo, S. J., Ulloa, F., Cotrufo, T., Ricolo, D., & Soriano, E. (2018) · Neural Regeneration Research · doi:10.4103/1673-5374.228710 · Cited by 26
Caputo, M., Gubar, O. S., Tóth, P., Vitale, N., Gasman, S., & Ory, S. (2025) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2025.110441 · Cited by 25
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Wu, X., Subramanian, S., Zhang, Y., Shi, B., Xia, J., Li, T., Guo, X., El‐Hassar, L., Szigeti‐Buck, K., Henao‐Mejia, J., et al. (2021) · Neuron · doi:10.1016/j.neuron.2021.01.006 · Cited by 25
Cole, A. A., & Reese, T. S. (2023) · Journal of Neuroscience · doi:10.1523/jneurosci.2195-22.2023 · Cited by 26
Nicholson-Fish, J. C., Cousin, M. A., & Smillie, K. J. (2015) · Neurochemical Research · doi:10.1007/s11064-015-1663-5 · Cited by 25
Hayashida, M., Tanifuji, S., Ma, H., Murakami, N., & Mochida, S. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.5028-14.2015 · Cited by 25
Beske, P. H., Bradford, A. B., Grynovicki, J. O., Glotfelty, E. J., Hoffman, K. M., Hubbard, K., Tuznik, K. M., & McNutt, P. M. (2015) · Toxicological Sciences · doi:10.1093/toxsci/kfv254 · Cited by 25
Mahapatra, S., Fan, F., & Lou, X. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1520937113 · Cited by 25
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Li, X., Qin, L., Li, Y., Yu, H., Zhang, Z., Tao, C.-L., Liu, Y., Xue, Y., Zhang, X., Xu, Z., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.06.006 · Cited by 25
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Kyung, J. W., Bae, J. R., Kim, D.-H., Song, W. K., & Kim, S. H. (2016) · Scientific Reports · doi:10.1038/srep31997 · Cited by 25
Pan, J., Peng, J., Li, X., Wang, H., Rong, X., & Peng, Y. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03232-y · Cited by 24
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Tran, V., Silva, M., & Marty, A. (2023) · iScience · doi:10.1016/j.isci.2023.106366 · Cited by 24
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Zhao, X., Yang, S., Kargbo-Hill, S. E., Clark, B., Manning, L., & Colón‐Ramos, D. A. (2023) · PLoS Biology · doi:10.1371/journal.pbio.3002030 · Cited by 26
Dani, N., Zhu, H., & Broadie, K. S. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.1484-14.2014 · Cited by 24
Poudel, K. R., Dong, Y., Yu, H., Su, X. A., Ho, T. T. G., Liu, Y., Schulten, K. J., & Bai, J. (2016) · Molecular Biology of the Cell · doi:10.1091/mbc.e16-04-0264 · Cited by 24
Upscaling X-ray nanoimaging to macroscopic specimens
Du, M., Di, Z. W., Gürsoy, D., Xian, R. P., Kozorovitskiy, Y., & Jacobsen, C. J. (2021) · Journal of Applied Crystallography · doi:10.1107/s1600576721000194 · Cited by 24
Nakakubo, Y., Abe, S., Yoshida, T., Takami, C., Isa, M., Wojcik, S. M., Brose, N., Takamori, S., & Hori, T. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.108040 · Cited by 23
Li, T.-N., Chen, Y.-J., Lu, T.-Y., Wang, Y.-T., Lin, H.-C., & Yao, C. (2020) · eLife · doi:10.7554/elife.60125 · Cited by 23
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Keine, C., Al-Yaari, M., Radulović, T., Thomas, C. I., Ramos, P. V., Guerrero‐Given, D., Ranjan, M., Taschenberger, H., Kamasawa, N., & Young, S. M. (2022) · eLife · doi:10.7554/elife.81505 · Cited by 23
Uchida, N., Ryu, Y., Takagi, Y., Yoshizawa, K., Suzuki, K., Anraku, Y., Ajioka, I., Shimokawa, N., Takagi, M., Hoshino, N., et al. (2023) · Journal of the American Chemical Society · doi:10.1021/jacs.2c12348 · Cited by 23
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Morton, A., Marland, J. R. K., & Cousin, M. A. (2015) · Journal of Neurochemistry · doi:10.1111/jnc.13132 · Cited by 23
The intravesicular cocktail and its role in the regulation of exocytosis
Estévez‐Herrera, J., González‐Santana, A., Baz‐Dávila, R., Machado, J. D., & Borges, R. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13609 · Cited by 23
Local protein dynamics during microvesicle exocytosis in neuroendocrine cells
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Cheung, G. T. Y., & Cousin, M. A. (2019) · Journal of Neurochemistry · doi:10.1111/jnc.14862 · Cited by 23
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Okamoto, Y., Lipstein, N., Hua, Y., Lin, K., Brose, N., Sakaba, T., & Midorikawa, M. (2016) · eLife · doi:10.7554/elife.14643 · Cited by 22
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Seitz, K. J., & Rizzoli, S. O. (2019) · Scientific Reports · doi:10.1038/s41598-019-44262-8 · Cited by 22
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Chen, Y., Hu, S., Wu, X., Xie, Z., Wang, Y., Wang, B., Li, X., Pei, Y., Gu, Y., Huang, K., et al. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2111051119 · Cited by 22
Adaptor protein-3 produces synaptic vesicles that release phasic dopamine
Jain, S., Yee, A. G., Maas, J., Gierok, S., Xu, H., Stansil, J. A., Eriksen, J., Nelson, A., Silm, K., Ford, C., et al. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2309843120 · Cited by 22
Balancing presynaptic release and endocytic membrane retrieval at hair cell ribbon synapses
Pangršič, T., & Vogl, C. (2018) · FEBS Letters · doi:10.1002/1873-3468.13258 · Cited by 22
Nanomachinery Organizing Release at Neuronal and Ribbon Synapses
Chakrabarti, R., & Wichmann, C. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20092147 · Cited by 22
Membrane Curvature, Trans-Membrane Area Asymmetry, Budding, Fission and Organelle Geometry
Aa, M., Mironov, A., Derganc, J., & Beznoussenko, G. V. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21207594 · Cited by 22
Mem3DG: Modeling membrane mechanochemical dynamics in 3D using discrete differential geometry
Zhu, C., Lee, C. T., & Rangamani, P. (2022) · Biophysical Reports · doi:10.1016/j.bpr.2022.100062 · Cited by 22
Resolving presynaptic structure by electron tomography
Perkins, G. A., Jackson, D., & Spirou, G. A. (2015) · Synapse · doi:10.1002/syn.21813 · Cited by 21
Trans-Membrane Area Asymmetry Controls the Shape of Cellular Organelles
Beznoussenko, G. V., Pilyugin, S. S., Geerts, W. J. C., Kozlov, M. M., Burger, K. N. J., Luini, A., Derganc, J., & Aa, M. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms16035299 · Cited by 21
Roy, R. D., Stefan, M. I., & Rosenmund, C. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00141 · Cited by 21
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Picco, A., & Kaksonen, M. (2018) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2018.06.005 · Cited by 21
Jin, Y.-H., Wu, X.-S., Shi, B., Zhang, Z., Guo, X., Gan, L., Chen, Z., & Wu, L. (2019) · Journal of Neuroscience · doi:10.1523/jneurosci.0182-19.2019 · Cited by 21
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Shin, W., Zucker, B., Kundu, N., Lee, S. H., Shi, B., Chan, C. Y., Guo, X., Harrison, J. T., Turechek, J. M., Hinshaw, J. E., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-31286-4 · Cited by 20
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Muth, S., Moschref, F., Freckmann, L., Mutschall, S., García-Plaza, I. H., Bahr, J. N., Petrović, A., Do, T. T., Schwarze, V., Archit, A., et al. (2025) · Molecular Biology of the Cell · doi:10.1091/mbc.e24-11-0519 · Cited by 20
Romeu, A., & Arola, L. (2014) · BMC Research Notes · doi:10.1186/1756-0500-7-188 · Cited by 20
Silbern, I., Pan, K., Fiošins, M., Bonn, S., Rizzoli, S. O., Fornasiero, E. F., Urlaub, H., & Jahn, R. (2021) · Molecular & Cellular Proteomics · doi:10.1016/j.mcpro.2021.100061 · Cited by 20
Ibghi, M., Kbiach, M. L. E., Leblad, B. R., Aboualaalaa, H., Hervé, F., Sibat, M., Chair, A., Masseret, E., Maamour, N., Daoudi, M., et al. (2022) · Environmental Monitoring and Assessment · doi:10.1007/s10661-022-10426-9 · Cited by 20
Perrais, D. (2022) · Bioscience Reports · doi:10.1042/bsr20211227 · Cited by 20
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Stevenson, N. L., White, I. J., McCormack, J. J., Robinson, C., Cutler, D. F., & Nightingale, T. D. (2017) · Journal of Cell Science · doi:10.1242/jcs.200840 · Cited by 19
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Santos, M., Foss, S., Park, C. K., & Voglmaier, S. M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0109824 · Cited by 18
Hirama, T., & Fairn, G. D. (2018) · Communicative & Integrative Biology · doi:10.1080/19420889.2018.1444306 · Cited by 18
Imler, E., Pyon, J. S., Kindelay, S. M., Torvund, M., Zhang, Y.-Q., Chandra, S. S., & Zinsmaier, K. E. (2019) · eLife · doi:10.7554/elife.46607 · Cited by 17
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Self-citationSposini, S., Rosendale, M., Claverie, L., Van, T. N. N., Jullié, D., & Perrais, D. (2020) · Nature Protocols · doi:10.1038/s41596-020-0371-z · Cited by 17
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Blumrich, E., Nicholson-Fish, J. C., Pronot, M., Davenport, E. C., Kurian, D., Cole, A. R., Smillie, K. J., & Cousin, M. A. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112633 · Cited by 16
Song, D., Yuan, L., Cui, N., Feng, C., Meng, L., Wang, X., Xiang, M., Liu, D., Wang, C., Zhang, Z., et al. (2023) · Journal of Neurochemistry · doi:10.1111/jnc.15974 · Cited by 16
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Piccini, A., Castroflorio, E., Valente, P., Guarnieri, F. C., Aprile, D., Michetti, C., Bramini, M., Giansante, G., Pinto, B., Savardi, A., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.11.073 · Cited by 15
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Metadata
- Authors
- Watanabe, S., Rost, B. R., Camacho-Pérez, M., Davis, M. W., Söhl-Kielczynski, B., Rosenmund, C., & Jorgensen, E. M.
- Affiliations
- Howard Hughes Medical Institute (US)
- Charité – Universitätsmedizin Berlin (DE)
- Corresponding author
- Rosenmund, Christian
- Venue
- Nature
- Published
- 2013-12-04
- Volume
- 504
- Issue
- 7479
- Pages
- 242-247
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC3957339
- OpenAlex
- W2093450191
- Cited by
- 607
- References
- 54
- Citations by year
- 2026: 26 · 2025: 40 · 2024: 44 · 2023: 47 · 2022: 53 · 2021: 44 · 2020: 53 · 2019: 62 · 2018: 51 · 2017: 54 · 2016: 36 · 2015: 58 · 2014: 38 · 2013: 1
- FWCI
- 25.72
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- DZNE Pub (submittedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institute of Neurological Disorders and Stroke (R37NS034307, NS034307, R01NS034307)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Keywords
- synaptic vesicle recycling, clathrin-mediated endocytosis, dynamin, actin polymerization, hippocampal synapses, neurotransmission, membrane internalization, active zone, optogenetic stimulation
- MeSH terms
- Actins, Action Potentials, Animals, Endocytosis, Exocytosis, Hippocampus, Membrane Fusion, Microscopy, Electron, Synaptic Transmission, Rhodopsin, Synapses, Synaptic Vesicles, Time Factors, Dynamins, Mice
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