The DOI matches its Crossref record; 130 of the 130 references it cites were found in a registry or an index.
The bone marrow niche for haematopoietic stem cells
Open accessAbstract
Niches are local tissue microenvironments that maintain and regulate stem cells. Haematopoiesis provides a model for understanding mammalian stem cells and their niches, but the haematopoietic stem cell (HSC) niche remains incompletely defined and beset by competing models. Recent progress has been made in elucidating the location and cellular components of the HSC niche in the bone marrow. The niche is perivascular, created partly by mesenchymal stromal cells and endothelial cells and often, but not always, located near trabecular bone. Outstanding questions concern the cellular complexity of the niche, the role of the endosteum and functional heterogeneity among perivascular microenvironments.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Non-haematopoietic stromal cells, including osteoblasts and osteoprogenitor cells, promote the maintenance of haematopoietic stem cells.95”
From The costs and benefits of senotherapeutics for human health (2022) · cites this paper as [95]
In the citing paper
“Other cell types that regulate HSC niches include osteoclasts, extracellular matrix, megakaryocytes, and calcium.9”
From Inflammatory bone marrow microenvironment (2019) · cites this paper as [9]
In the citing paper
“Although MSCs are a heterogeneous population and still require better characterization by surface markers, perivascular mesenchymal cells that express CD146 in humans and Cxcl12-green fluorescent protein, Nestin-green fluorescent protein, full-length Leptin receptor, Prx-1-Cre, Osterix-Cre, and inducible Mx-1-Cre in mice generate osteoblastic cells and express factors that promote the maintenance”
From Inflammatory bone marrow microenvironment (2019) · cites this paper as [9]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Targeting Hypoxia-Inducible Factors for the Treatment of Anemia in Chronic Kidney Disease Patients
Locatelli, F., Fishbane, S. N., Block, G. A., & Macdougall, I. C. (2017) · American Journal of Nephrology · doi:10.1159/000455166 · Cited by 4,836
Cytokine-mediated regulation of CXCR4 expression in human neutrophils
Nagase, H., Miyamasu, M., Yamaguchi, M., Imanishi, M., Tsuno, N. H., Matsushima, K., Yamamoto, K., Morita, Y., & Hirai, K. (2002) · Journal of Leukocyte Biology · doi:10.1189/jlb.71.4.711 · Cited by 4,713
A Direct Measurement of the Radiation Sensitivity of Normal Mouse Bone Marrow Cells1
Till, J. E., & McCulloch, E. A. (2010) · Radiation Research · doi:10.1667/rrxx28.1 · Cited by 4,036
A Direct Measurement of the Radiation Sensitivity of Normal Mouse Bone Marrow Cells
Till, J. E., & McCulloch, E. A. (1961) · Radiation Research · doi:10.2307/3570892 · Cited by 3,848
Osteoblastic cells regulate the haematopoietic stem cell niche
Calvi, L. M., Adams, G. B., Weibrecht, K. W., Weber, J. M., Olson, D. P., Knight, M. C., Martin, R. P., Schipani, E., Pajevic, P. D., Bringhurst, F. R., et al. (2003) · Nature · doi:10.1038/nature02040 · Cited by 3,559
Self-citationMesenchymal and haematopoietic stem cells form a unique bone marrow niche
Méndez‐Ferrer, S., Michurina, T. V., Ferraro, F., Mazloom, A. R., MacArthur, B. D., Lira, S. A., Scadden, D. T., Ma’ayan, A., Enikolopov, G., & Frenette, P. S. (2010) · Nature · doi:10.1038/nature09262 · Cited by 3,381
Self-citationKiel, M. J., Yilmaz, Ö. H., Iwashita, T., Yilmaz, O. H., Terhorst, C., & Morrison, S. J. (2005) · Cell · doi:10.1016/j.cell.2005.05.026 · Cited by 3,168
Self-citationIdentification of the haematopoietic stem cell niche and control of the niche size
Zhang, J., Niu, C. S., Ye, L., Huang, H., He, X. C., Tong, W.-G., Ross, J., Haug, J., Johnson, T. J., Feng, J. Q., et al. (2003) · Nature · doi:10.1038/nature02041 · Cited by 2,948
Purification and Characterization of Mouse Hematopoietic Stem Cells
Spangrude, G. J., Heimfeld, S., & Weissman, I. L. (1988) · Science · doi:10.1126/science.2898810 · Cited by 2,908
Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development
Zou, Y.-R., Kottmann, A. H., Kuroda, M., Taniuchi, I., & Littman, D. R. (1998) · Nature · doi:10.1038/31269 · Cited by 2,531
Flagged first, then by citations
Cited by
Sorted by citations
Items 601–700 of 1,005
Bone-marrow mimicking biomaterial niches for studying hematopoietic stem and progenitor cells
Nelson, M. R., & Roy, K. (2016) · Journal of Materials Chemistry B · doi:10.1039/c5tb02644j · Cited by 42
Su, Q., Zhang, B., Zhang, L., Dang, T., Rowley, D. R., Ittmann, M., & Xin, L. (2016) · Oncogene · doi:10.1038/onc.2016.232 · Cited by 41
The Mesenchymal Precursor Cell Marker Antibody STRO-1 Binds to Cell Surface Heat Shock Cognate 70
Fitter, S., Gronthos, S., Ooi, S. S., & Zannettino, A. C. W. (2016) · Stem Cells · doi:10.1002/stem.2560 · Cited by 40
Kong, Y., Wang, Y.-T., Cao, X.-N., Song, Y., Chen, Y., Sun, Y., Wang, Y., Zhang, X., Xu, L., & Huang, X. (2017) · Journal of Translational Medicine · doi:10.1186/s12967-017-1159-y · Cited by 41
Karigane, D., & Takubo, K. (2017) · International Journal of Hematology · doi:10.1007/s12185-017-2261-x · Cited by 40
Therapeutic Antibodies for Myeloid Neoplasms—Current Developments and Future Directions
Schürch, C. M. (2018) · Frontiers in Oncology · doi:10.3389/fonc.2018.00152 · Cited by 42
Spred1 Safeguards Hematopoietic Homeostasis against Diet-Induced Systemic Stress
Tadokoro, Y., Hoshii, T., Yamazaki, S., Eto, K., Ema, H., Kobayashi, M., Ueno, M., Ohta, K., Arai, Y., Hara, E., et al. (2018) · Cell stem cell · doi:10.1016/j.stem.2018.04.002 · Cited by 42
Holzwarth, K., Köhler, R., Philipsen, L., Tokoyoda, K., Ladyhina, V., Wählby, C., Niesner, R. A., & Hauser, A. E. (2018) · Cytometry Part A · doi:10.1002/cyto.a.23526 · Cited by 40
Lee, G., Jeong, S., Lee, H., & Oh, I. (2019) · Scientific Reports · doi:10.1038/s41598-018-36999-5 · Cited by 44
Beta-Adrenergic Signaling in Tumor Immunology and Immunotherapy
Wang, W., & Cao, X. (2019) · Critical Reviews in Immunology · doi:10.1615/critrevimmunol.2019031188 · Cited by 43
Hira, V. V. V., Breznik, B., Vittori, M., de Jong, A. L., Mlakar, J., Oostra, R., Khurshed, M., Molenaar, R. J., Lah, T. T., & Noorden, C. J. F. V. (2019) · Journal of Histochemistry & Cytochemistry · doi:10.1369/0022155419878416 · Cited by 41
EBF1-deficient bone marrow stroma elicits persistent changes in HSC potential
Derecka, M., Herman, J. S., Cauchy, P., Ramamoorthy, S., Lupar, E., Grün, D., & Grosschedl, R. (2020) · Nature Immunology · doi:10.1038/s41590-020-0595-7 · Cited by 40
Controversies on the Consequences of Iron Overload and Chelation in MDS
Vinchi, F., Hell, S., & Platzbecker, U. (2020) · HemaSphere · doi:10.1097/hs9.0000000000000357 · Cited by 43
Role for Leptin and Leptin Receptors in Stem Cells During Health and Diseases
Trinh, T. L. P., & Broxmeyer, H. E. (2021) · Stem Cell Reviews and Reports · doi:10.1007/s12015-021-10132-y · Cited by 46
Bapat, A., Schippel, N., Shi, X., Jasbi, P., Gu, H., Kala, M., Sertil, A., & Sharma, S. (2021) · Experimental Hematology · doi:10.1016/j.exphem.2021.02.012 · Cited by 39
García‐García, A., Klein, T., Born, G., Hilpert, M., Scherberich, A., Lengerke, C., Skoda, R. C., Bourgine, P. E., & Martín, I. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2114227118 · Cited by 41
Genetic and Epigenetic Mechanisms That Maintain Hematopoietic Stem Cell Function
Kosan, C., & Godmann, M. (2015) · Stem Cells International · doi:10.1155/2016/5178965 · Cited by 47
The Role of Inflammation in the Initiation and Progression of Myeloid Neoplasms
Balandrán, J. C., Lasry, A., & Aifantis, I. (2023) · Blood Cancer Discovery · doi:10.1158/2643-3230.bcd-22-0176 · Cited by 44
Regenerating human skeletal muscle forms an emerging niche in vivo to support PAX7 cells
Hicks, M. R., Saleh, K. K., Clock, B., Gibbs, D. E., Yang, M., Younesi, S., Gane, L., Gutierrez-Garcia, V., Xi, H., & Pyle, A. D. (2023) · Nature Cell Biology · doi:10.1038/s41556-023-01271-0 · Cited by 38
Sato, F., Miyaoka, Y., Miyajima, A., & Tanaka, M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0116209 · Cited by 40
Polymeric Electrospinning for Musculoskeletal Regenerative Engineering
Narayanan, N., Jiang, C., Uzunallı, G., Thankappan, S. K., Laurencin, C. T., & Deng, M. (2016) · Regenerative Engineering and Translational Medicine · doi:10.1007/s40883-016-0013-8 · Cited by 40
Behrens, K., Triviai, I., Schwieger, M., Tekin, N. S., Alawi, M., Spohn, M., Indenbirken, D., Ziegler, M., Müller, U., Alexander, W. S., et al. (2016) · Blood · doi:10.1182/blood-2015-09-668129 · Cited by 40
Adamiak, M., Abdelbaset‐Ismail, A., Moore, J. B., Zhao, J. Z., Abdel‐Latif, A., Wysoczynski, M., & Ratajczak, M. Z. (2016) · Stem Cell Reviews and Reports · doi:10.1007/s12015-016-9693-1 · Cited by 40
Nusspaumer, G., Jaiswal, S., Barbero, A., Reinhardt, R., Ishay-Ronen, D., Haumer, A., Lufkin, T., Martín, I., & Zeller, R. (2017) · Stem Cell Reports · doi:10.1016/j.stemcr.2017.08.007 · Cited by 40
Hira, V. V. V., Wormer, J. R., Kakar, H., Breznik, B., van der Swaan, B., Hulsbos, R., Tigchelaar, W., Tonar, Z., Khurshed, M., Molenaar, R. J., et al. (2018) · Journal of Histochemistry & Cytochemistry · doi:10.1369/0022155417749174 · Cited by 42
Addressing the Manufacturing Challenges of Cell-Based Therapies
Fuzeta, M. D. A., Branco, A. D. D. M., Fernandes‐Platzgummer, A., da Silva, C. L., & Cabral, J. M. S. (2019) · Advances in biochemical engineering, biotechnology · doi:10.1007/10_2019_118 · Cited by 42
The vascular niche controls Drosophila hematopoiesis via fibroblast growth factor signaling
Letourneau, M., Morin-Poulard, I., Tian, Y., Vanzo, N. F., & Crozatier, M. (2021) · eLife · doi:10.7554/elife.64672 · Cited by 40
Therapeutic Treatments for Osteoporosis—Which Combination of Pills Is the Best among the Bad?
Tonk, C. H., Shoushrah, S. H., Babczyk, P., Khaldi-Hansen, B. E., Schulze, M., Herten, M., & Tobiasch, E. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031393 · Cited by 44
Reddy, P. N. G., Radu, M., Xu, K., Wood, J. A., Harris, C. E., Chernoff, J., & Williams, D. A. (2016) · Blood · doi:10.1182/blood-2016-01-693572 · Cited by 40
Critical requirement of VEGF-C in transition to fetal erythropoiesis
Fang, S., Nurmi, H. J., Heinolainen, K., Chen, S., Salminen, E., Saharinen, P., Mikkola, H. K. A., & Alitalo, K. K. (2016) · Blood · doi:10.1182/blood-2015-12-687970 · Cited by 40
Sigma‐1 receptor attenuates osteoclastogenesis by promoting ER‐associated degradation of SERCA2
Wei, X., Zheng, Z., Feng, Z., Zheng, L., Tao, S., Zheng, B., Huang, B. H., Zhang, X., Liu, J., Chen, Y., et al. (2022) · EMBO Molecular Medicine · doi:10.15252/emmm.202115373 · Cited by 38
Key Factors for Thymic Function and Development
Shichkin, V. P., & Antica, M. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.926516 · Cited by 42
Hematopoietic Stem Cells and Their Niche in Bone Marrow
Kwon, M., Kim, B. S., Yoon, S., Oh, S., & Lee, D. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25136837 · Cited by 42
Self-organization of the hematopoietic vascular niche and emergent innate immunity on a chip
Georgescu, A., Oved, J. H., Galarraga, J. H., Cantrell, T., Mehta, S., Dulmovits, B. M., Olson, T. S., Fattahi, P., Wang, A., Candarlioglu, P. L., et al. (2024) · Cell stem cell · doi:10.1016/j.stem.2024.11.003 · Cited by 40
Transcription factor‐mediated reprogramming toward hematopoietic stem cells
Ebina, W., & Rossi, D. J. (2015) · The EMBO Journal · doi:10.15252/embj.201490804 · Cited by 41
Prospective isolation of resident adult human mesenchymal stem cell population from multiple organs
Mabuchi, Y., & Matsuzaki, Y. (2015) · International Journal of Hematology · doi:10.1007/s12185-015-1921-y · Cited by 39
Gao, A., Gong, Y., Zhu, C., Yang, W., Li, Q., Zhao, M., Ma, S., Li, J., Hao, S., Cheng, H., et al. (2019) · Haematologica · doi:10.3324/haematol.2018.214593 · Cited by 38
Immune cell regulation of the hair cycle
Wang, E. C. E., & Higgins, C. A. (2020) · Experimental Dermatology · doi:10.1111/exd.14070 · Cited by 40
Cremer, S., Schloss, M. J., Vinegoni, C., Foy, B. H., Zhang, S., Rohde, D., Hulsmans, M., Feruglio, P. F., Schmidt, S., Wojtkiewicz, G. R., et al. (2020) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2019.12.056 · Cited by 40
Deterioration of hematopoietic autophagy is linked to osteoporosis
Yuan, Y., Fang, Y., Zhu, L., Gu, Y., Li, L., Qian, J., Zhao, R., Zhang, P., Li, J., Zhang, H., et al. (2020) · Aging Cell · doi:10.1111/acel.13114 · Cited by 39
The erythroblastic island niche: modeling in health, stress, and disease
May, A., & Forrester, L. M. (2020) · Experimental Hematology · doi:10.1016/j.exphem.2020.09.185 · Cited by 44
Agarwal, P., Li, H., Choi, K., Hueneman, K. M., He, J., Welner, R. S., Starczynowski, D. T., & Bhatia, R. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109386 · Cited by 40
Modelling acute myeloid leukemia (AML): What’s new? A transition from the classical to the modern
Dozzo, A., Galvin, A., Shin, J., Scalia, S., O’Driscoll, C. M., & Ryan, K. B. (2022) · Drug Delivery and Translational Research · doi:10.1007/s13346-022-01189-4 · Cited by 40
Novack, D. V., & Cassat, J. E. (2020) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.4279 · Cited by 37
A Molecular Profile of the Endothelial Cell Response to Ionizing Radiation
Himburg, H. A., Sasine, J. P., Yan, X., Kan, J., Dressman, H. K., & Chute, J. P. (2016) · Radiation Research · doi:10.1667/rr14444.1 · Cited by 38
Live imaging of stem cells: answering old questions and raising new ones
Park, S., Greco, V., & Cockburn, K. (2016) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2016.07.004 · Cited by 36
Modular flow chamber for engineering bone marrow architecture and function
Buduo, C. A. D., Soprano, P. M., Tozzi, L., Marconi, S., Auricchio, F., Kaplan, D. L., & Balduini, A. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.08.006 · Cited by 38
A Chemoattractant-Guided Walk Through Lymphopoiesis
Lim, V., Zehentmeier, S., Fistonich, C., & Pereira, J. P. (2017) · Advances in immunology · doi:10.1016/bs.ai.2017.02.001 · Cited by 40
Efforts to enhance blood stem cell engraftment: Recent insights from zebrafish hematopoiesis
Perlin, J. R., Robertson, A. L., & Zon, L. I. (2017) · The Journal of Experimental Medicine · doi:10.1084/jem.20171069 · Cited by 36
Zhao, D., Liu, L., Chen, Q., Wang, F., Li, Q., Zeng, Q., Huang, J., Luo, M., Li, W., Zheng, Y., et al. (2018) · Stem Cell Research & Therapy · doi:10.1186/s13287-018-0902-5 · Cited by 38
Lack of Adipocytes Alters Hematopoiesis in Lipodystrophic Mice
Wilson, A., Fu, H., Schiffrin, M., Winkler, C., Koufany, M., Jouzeau, J., Bonnet, N., Gilardi, F., Renevey, F., Luther, S. A., et al. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02573 · Cited by 38
Chen, Y., Tang, C. S., Zhang, M., Huang, W., Xu, Y. K., Sun, H.-Y., Yang, F., Song, L., Wang, H., Mu, L., et al. (2019) · Leukemia · doi:10.1038/s41375-019-0458-0 · Cited by 37
Stress and catecholamines modulate the bone marrow microenvironment to promote tumorigenesis
Hanns, P., Paczulla, A., Medinger, M., Konantz, M., & Lengerke, C. (2019) · Cell Stress · doi:10.15698/cst2019.07.192 · Cited by 41
Caloric restriction maintains stem cells through niche and regulates stem cell aging
Maharajan, N., Vijayakumar, K. A., Jang, C. H., & Cho, G. (2019) · Journal of Molecular Medicine · doi:10.1007/s00109-019-01846-1 · Cited by 38
Poirier, Y. P., Belley, M. D., Dewhirst, M. W., Yoshizumic, T. T., & Down, J. D. (2020) · Radiation Research · doi:10.1667/rade-20-00039.1 · Cited by 38
TREM2 acts as a receptor for IL-34 to suppress acute myeloid leukemia in mice
Xie, X., Zhang, W., Xiao, M., Wei, T., Qiu, Y., Qiu, J., Wang, H., Qiu, Z., Zhang, S., Pan, Y., et al. (2023) · Blood · doi:10.1182/blood.2022018619 · Cited by 34
Bone marrow niches orchestrate stem-cell hierarchy and immune tolerance
Furuhashi, K., Kakiuchi, M., Ueda, R., Oda, H., Ummarino, S., Ebralidze, A. K., Bassal, M. A., Chen, M., Sato, T., Lyu, J., et al. (2025) · Nature · doi:10.1038/s41586-024-08352-6 · Cited by 39
Bone marrow microenvironment modulation of acute lymphoblastic leukemia phenotype
Moses, B. S., Slone, W. L., Thomas, P., Evans, R., Piktel, D., Angel, P. M., Walsh, C. M., Cantrell, P. S., Rellick, S. L., Martin, K. H., et al. (2015) · Experimental Hematology · doi:10.1016/j.exphem.2015.09.003 · Cited by 37
Gullo, F., van der Garde, M., Russo, G. L., Pennisi, M. A., Motta, S., Pappalardo, F., & Watt, S. M. (2015) · Bioinformatics · doi:10.1093/bioinformatics/btv172 · Cited by 37
Kwak, H., Salvucci, O., Weigert, R., Martinez-Torrecuadrada, J. L., Henkemeyer, M. J., Poulos, M. G., Butler, J. M., & Tosato, G. (2016) · Journal of Clinical Investigation · doi:10.1172/jci87848 · Cited by 39
Greenberg, J. M., Carballosa, C. M., & Cheung, H. S. (2017) · Stem Cells Translational Medicine · doi:10.1002/sctm.17-0060 · Cited by 38
Chemokines as a Conductor of Bone Marrow Microenvironment in Chronic Myeloid Leukemia
Mukaida, N., Tanabe, Y., & Baba, T. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18081824 · Cited by 38
Geographic clonal tracking in macaques provides insights into HSPC migration and differentiation
Wu, C., Espinoza, D. A., Koelle, S., Potter, E. L., Lu, R., Li, B., Yang, D., Fan, X., Donahue, R. E., Roederer, M., et al. (2017) · The Journal of Experimental Medicine · doi:10.1084/jem.20171341 · Cited by 37
Regulation of unfolded protein response in hematopoietic stem cells
Sigurðsson, V., & Miharada, K. (2018) · International Journal of Hematology · doi:10.1007/s12185-018-2458-7 · Cited by 38
Eltoukhy, H. S., Sinha, G., Moore, C. A., Gergues, M., & Rameshwar, P. (2018) · Biochimie · doi:10.1016/j.biochi.2018.05.018 · Cited by 37
Kim, A., Shim, S., Kim, M., Myung, J. K., & Park, S. (2018) · Scientific Reports · doi:10.1038/s41598-018-27666-w · Cited by 38
Kuroyanagi, G., Adapala, N. S., Yamaguchi, R., Kamiya, N., Deng, Z., Aruwajoye, O. O., Kutschke, M. J., Chen, E. Y., Jo, C.-H., Ren, Y., et al. (2018) · Bone · doi:10.1016/j.bone.2018.08.011 · Cited by 37
A Three-Dimensional Dense Collagen Hydrogel to Model Cancer Cell/Osteoblast Interactions
James-Bhasin, M., Siegel, P. M., & Nazhat, S. N. (2018) · Journal of Functional Biomaterials · doi:10.3390/jfb9040072 · Cited by 37
Adult Cardiac Stem Cell Aging: A Reversible Stochastic Phenomenon?
Cianflone, E., Torella, M., Chimenti, C., Angelis, A. D., Beltrami, A. P., Urbanek, K., Rota, M., & Torella, D. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/5813147 · Cited by 40
Mase, A., Augsburger, J., & Brückner, K. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.630272 · Cited by 34
Bertolin, J., Sánchez, V., Ribera, A., Jaén, M. L., García, M., Pujol, A., Sánchez, X., MUÑOZ, S. A., Marcó, S., Pérez, J., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-25697-y · Cited by 39
Genetic abnormalities associated with acute lymphoblastic leukemia
Yokota, T., & Kanakura, Y. (2016) · Cancer Science · doi:10.1111/cas.12927 · Cited by 37
Lipoprotein lipase regulates hematopoietic stem progenitor cell maintenance through DHA supply
Liu, C., Han, T., Stachura, D. L., Wang, H., Vaisman, B. L., Kim, J., Klemke, R. L., Remaley, A. T., Rana, T. M., Traver, D. J., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-03775-y · Cited by 37
Regulation of Hematopoiesis and Hematological Disease by TGF-β Family Signaling MoleculesPreprint
Naka, K., & Hirao, A. (2017) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a027987 · Cited by 37
Interactions of B-lymphocytes and bone cells in health and disease
Grčević, D., Sanjay, A., & Lorenzo, J. (2023) · Bone · doi:10.1016/j.bone.2021.116296 · Cited by 36
Yuan, Y., Zhou, C., Yang, Q., Ma, S., Wang, X., Guo, X., Ding, Y., Tang, J., Zeng, Y., & Li, D. (2019) · Virus Research · doi:10.1016/j.virusres.2019.197756 · Cited by 36
EphB4 Expressing Stromal Cells Exhibit an Enhanced Capacity for Hematopoietic Stem Cell Maintenance
Nguyen, T. M., Arthur, A., Panagopoulos, R. A., Paton, S., Hayball, J. D., Zannettino, A. C. W., Purton, L. E., Matsuo, K., & Gronthos, S. (2015) · Stem Cells · doi:10.1002/stem.2069 · Cited by 36
Rödling, L., Volz, E. M., Raić, A., Brändle, K., Franzreb, M., & Lee‐Thedieck, C. (2018) · Advanced Healthcare Materials · doi:10.1002/adhm.201701403 · Cited by 36
Role of Schwann cells in cutaneous wound healing
da Silva, W. N., Leonel, C., Prazeres, P. H. D. M., Sena, I. F. G., Guerra, D. A. P., Heller, D., Diniz, I. M. A., Fortuna, V., Mintz, A., & Birbrair, A. (2018) · Wound Repair and Regeneration · doi:10.1111/wrr.12647 · Cited by 36
Cao, D., Song, J., Ling, S., Niu, S., Lu, L., Cui, Z., Li, Y., Hao, S., Zhong, G., Qi, Z., et al. (2019) · The FASEB Journal · doi:10.1096/fj.201802421rr · Cited by 36
Single‐cell transcriptomes of murine bone marrow stromal cells reveal niche‐associated heterogeneity
Addo, R., Heinrich, F., Heinz, G. A., Schulz, D., Sercan-Alp, Ö., Lehmann, K., Tran, C. L., Bardua, M., Matz, M., Löhning, M., et al. (2019) · European Journal of Immunology · doi:10.1002/eji.201848053 · Cited by 36
Budgude, P., Kale, V. P., & Vaidya, A. (2020) · Cell Biology International · doi:10.1002/cbin.11313 · Cited by 36
CD74 is a regulator of hematopoietic stem cell maintenance
Becker-Herman, S., Rozenberg, M., Hillel-Karniel, C., Gil-Yarom, N., Kramer, M. P., Barak, A. F., Sever, L., David, K., Radomir, L., Lewinsky, H., et al. (2021) · PLoS Biology · doi:10.1371/journal.pbio.3001121 · Cited by 35
A systematic dissection of human primary osteoblasts in vivo at single-cell resolution
Gong, Y., Yang, J., Li, X., Zhou, C., Chen, Y., Wang, Z., Qiu, X., Liu, Y., Zhang, H., Greenbaum, J., et al. (2021) · Aging · doi:10.18632/aging.203452 · Cited by 35
Yu, Z., Yang, W., He, X., Chen, C., Li, W., Zhao, L., Liu, L., Liu, J., Xie, L., Zhang, Y., et al. (2021) · Blood · doi:10.1182/blood.2021011644 · Cited by 36
Mesenchymal Stem Cells for Cardiac Repair
Al-Khani, A. M., Khalifa, M., & Haider, K. H. (2022) · Springer eBooks · doi:10.1007/978-981-16-6016-0_11-1 · Cited by 35
Galli, D., Vitale, M., & Vaccarezza, M. (2014) · BioMed Research International · doi:10.1155/2014/762695 · Cited by 36
Role of the reprogramming factor KLF4 in blood formation
Park, C. S., Shen, Y., Lewis, A. H., & Lacorazza, H. D. (2016) · Journal of Leukocyte Biology · doi:10.1189/jlb.1ru1215-539r · Cited by 34
Hypoxia‐inducible micro RNA ‐210 regulates the DIMT 1‐ IRF 4 oncogenic axis in multiple myeloma
Ikeda, S., Kitadate, A., Abe, F., Saitoh, H., Michishita, Y., Hatano, Y., Kawabata, Y., Kitabayashi, A., Teshima, K., Kume, M., et al. (2017) · Cancer Science · doi:10.1111/cas.13183 · Cited by 36
Targeting the bone marrow microenvironment in acute leukemia
Karantanou, C., Godavarthy, P. S., & Krause, D. S. (2018) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.1080/10428194.2018.1434886 · Cited by 38
Bone, inflammation and the bone marrow niche in chronic kidney disease: what do we know?
Mazzaferro, S., Cianciolo, G., Pascalis, A. D., Guglielmo, C., Ureña, P., Bover, J., Tartaglione, L., Pasquali, M., & Manna, G. L. (2018) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfy115 · Cited by 36
Liu, F. D., Tam, K., Pishesha, N., Poon, Z., & Vliet, K. J. V. (2018) · Stem Cell Research & Therapy · doi:10.1186/s13287-018-0982-2 · Cited by 35
Bonilla, X., Vanegas, N.-D. P., & Vernot, J. (2019) · Stem Cells International · doi:10.1155/2019/3864948 · Cited by 36
Ehnert, S., Rinderknecht, H., Aspera-Werz, R. H., Häussling, V., & Nussler, A. K. (2020) · Archives of Toxicology · doi:10.1007/s00204-020-02906-z · Cited by 35
The Versatility of Sirtuin-1 in Endocrinology and Immunology
Rasha, F. A., Mims, B. M., Castro‐Piedras, I., Barnes, B. J., Grisham, M. B., Rahman, R. L., & Pruitt, K. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.589016 · Cited by 35
Stem cell homing in periodontal tissue regeneration
Meng, L., Wei, Y., Liang, Y., Hu, Q. S., & Xie, H. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.1017613 · Cited by 35
Endothelial Progenitor Cells in the Host Defense Response
Shi, X., Seidle, K. A., Simms, K. J., Dong, F., Chilian, W. M., & Zhang, P. (2022) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2022.108315 · Cited by 37
Cellular crosstalk in the bone marrow niche
Huang, Z., Iqbal, Z., Zhao, Z., Liu, J., Alabsi, A. M., Shabbir, M., Mahmood, A., Liang, Y., Li, W., & Deng, Z. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-05900-6 · Cited by 34
Han, Y., Sarkar, H., Xu, Z., Lopez-Darwin, S. L., Wei, Y., Hang, X., Liu, F., Tran, K., Wang, W., Miller, J. M., et al. (2025) · Cell · doi:10.1016/j.cell.2025.08.013 · Cited by 43
Boutter, J., Huang, Y., Marovca, B., Vonderheit, A., Grotzer, M. A., Eckert, C., Cario, G., Wollscheid, B., Horváth, P., Bornhauser, B. C., et al. (2014) · Oncotarget · doi:10.18632/oncotarget.2572 · Cited by 35
Metadata
- Authors
- Morrison, S. J., & Scadden, D. T.
- Affiliations
- Howard Hughes Medical Institute (US)
- Harvard University (US)
- Corresponding author
- Morrison, Sean J.
- Scadden, David T.
- Venue
- Nature
- Published
- 2014-01
- Volume
- 505
- Issue
- 7483
- Pages
- 327-334
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC4514480
- OpenAlex
- W2149053153
- Semantic Scholar
- 63cdd906a38c49f8d452a64cb77d5a597cfbfb38
- Cited by
- 2,451
- References
- 130
- Citations by year
- 2026: 139 · 2025: 176 · 2024: 141 · 2023: 177 · 2022: 194 · 2021: 210 · 2020: 226 · 2019: 225 · 2018: 240 · 2017: 223 · 2016: 225 · 2015: 184 · 2014: 89
- FWCI
- 36.68
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- Howard Hughes Medical Institute
- National Heart, Lung, and Blood Institute (HL096372, R01HL044851, R03HL096372, HL044851, HL097760, R01HL097760)
- National Institute of Biomedical Imaging and Bioengineering (R01EB014703, EB014703)
- Topics
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
- Health Sciences › Medicine › Hematology › Multiple Myeloma Research and Treatments
- Keywords
- hematopoietic stem cells, bone marrow microenvironment, hematopoiesis, perivascular niche, mesenchymal stem cells, endothelial cells, trabecular bone, endosteum, stem cell niche
- MeSH terms
- Animals, Bone and Bones, Bone Marrow, Hematopoietic Stem Cells, Humans, Osteoblasts, Endothelial Cells, Stem Cell Niche, Mesenchymal Stem Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review