The bone marrow niche for haematopoietic stem cells

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A Direct Measurement of the Radiation Sensitivity of Normal Mouse Bone Marrow Cells1

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Osteoblastic cells regulate the haematopoietic stem cell niche

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Mesenchymal and haematopoietic stem cells form a unique bone marrow niche

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SLAM Family Receptors Distinguish Hematopoietic Stem and Progenitor Cells and Reveal Endothelial Niches for Stem Cells

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Identification of the haematopoietic stem cell niche and control of the niche size

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Purification and Characterization of Mouse Hematopoietic Stem Cells

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Maintenance of the Hematopoietic Stem Cell Pool by CXCL12-CXCR4 Chemokine Signaling in Bone Marrow Stromal Cell Niches

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Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1

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Self-renewing osteoprogenitors in bone marrow sinusoids can organize a hematopoietic microenvironment

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Conditions controlling the proliferation of haemopoietic stem cells in vitro

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Endothelial and perivascular cells maintain haematopoietic stem cells

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Stem Cells and Niches: Mechanisms That Promote Stem Cell Maintenance throughout Life

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Tie2/Angiopoietin-1 Signaling Regulates Hematopoietic Stem Cell Quiescence in the Bone Marrow Niche

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Hematopoietic Stem Cells Reversibly Switch from Dormancy to Self-Renewal during Homeostasis and Repair

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The stem-cell niche as an entity of action

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Recruitment of Stem and Progenitor Cells from the Bone Marrow Niche Requires MMP-9 Mediated Release of Kit-Ligand

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A Stem Cell Molecular Signature

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Signals from the Sympathetic Nervous System Regulate Hematopoietic Stem Cell Egress from Bone Marrow

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CXCL12 in early mesenchymal progenitors is required for haematopoietic stem-cell maintenance

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Haematopoietic stem cells and early lymphoid progenitors occupy distinct bone marrow niches

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G-CSF induces stem cell mobilization by decreasing bone marrow SDF-1 and up-regulating CXCR4

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Haematopoietic stem cell release is regulated by circadian oscillations

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Arteriolar niches maintain haematopoietic stem cell quiescence

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Direct measurement of local oxygen concentration in the bone marrow of live animals

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Bone progenitor dysfunction induces myelodysplasia and secondary leukaemia

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Hereditary Anemias of the Mouse: A Review for Geneticists

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Live-animal tracking of individual haematopoietic stem/progenitor cells in their niche

Celso, C. L., Fleming, H. E., Wu, J. W., Zhao, C. X., Miake-Lye, S., Fujisaki, J., Côté, D. C., Rowe, D. W., Lin, C. P., & Scadden, D. T. (2008) · Nature · doi:10.1038/nature07434 · Cited by 945

Physiological Migration of Hematopoietic Stem and Progenitor Cells

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The distribution of colony‐forming cells among spleen colonies

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Bone marrow CD169+ macrophages promote the retention of hematopoietic stem and progenitor cells in the mesenchymal stem cell niche

Chow, A. T., Lucas, D., Hidalgo, A., Méndez‐Ferrer, S., Hashimoto, D., Scheiermann, C., Battista, M., Leboeuf, M., Prophete, C., van Rooijen, N., et al. (2011) · The Journal of Experimental Medicine · doi:10.1084/jem.20101688 · Cited by 914

The Essential Functions of Adipo-osteogenic Progenitors as the Hematopoietic Stem and Progenitor Cell Niche

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Regulation of the HIF-1α Level Is Essential for Hematopoietic Stem Cells

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In vivo imaging of specialized bone marrow endothelial microdomains for tumour engraftment

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Stem Cell Factor and Hematopoiesis

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Distribution of hematopoietic stem cells in the bone marrow according to regional hypoxia

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Prospective identification, isolation, and systemic transplantation of multipotent mesenchymal stem cells in murine bone marrow

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c-Myc controls the balance between hematopoietic stem cell self-renewal and differentiation

Wilson, A., Murphy, M. J., Oskarsson, T., Kaloulis, K., Bettess, M. D., Oser, G. M., Pasche, A.-C., Knabenhans, C., MacDonald, H. R., & Trumpp, A. (2004) · Genes & Development · doi:10.1101/gad.313104 · Cited by 823

Molecular cloning and structure of a pre-B-cell growth-stimulating factor.

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Thrombopoietin/MPL Signaling Regulates Hematopoietic Stem Cell Quiescence and Interaction with the Osteoblastic Niche

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Osteopontin, a key component of the hematopoietic stem cell niche and regulator of primitive hematopoietic progenitor cells

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Hematopoiesis is severely altered in mice with an induced osteoblast deficiency

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Bone marrow macrophages maintain hematopoietic stem cell (HSC) niches and their depletion mobilizes HSCs

Winkler, I. G., Sims, N. A., Pettit, A. R., Barbier, V., Nowlan, B., Helwani, F., Poulton, I. J., van Rooijen, N., Alexander, K. A., Raggatt, L. J., et al. (2010) · Blood · doi:10.1182/blood-2009-11-253534 · Cited by 801

Nonmyelinating Schwann Cells Maintain Hematopoietic Stem Cell Hibernation in the Bone Marrow Niche

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Rhythmic Modulation of the Hematopoietic Niche through Neutrophil Clearance

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Stem cell engraftment at the endosteal niche is specified by the calcium-sensing receptor

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Osteoclasts degrade endosteal components and promote mobilization of hematopoietic progenitor cells

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Expression and function of c-kit in hemopoietic progenitor cells.

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Osteopontin is a hematopoietic stem cell niche component that negatively regulates stem cell pool size

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SLAM Family Markers Resolve Functionally Distinct Subpopulations of Hematopoietic Stem Cells and Multipotent Progenitors

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Endothelial Cells Are Essential for the Self-Renewal and Repopulation of Notch-Dependent Hematopoietic Stem Cells

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Engraftment and Reconstitution of Hematopoiesis Is Dependent on VEGFR2-Mediated Regeneration of Sinusoidal Endothelial Cells

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Endogenous Bone Marrow MSCs Are Dynamic, Fate-Restricted Participants in Bone Maintenance and Regeneration

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The journey of developing hematopoietic stem cells

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Myeloproliferative neoplasia remodels the endosteal bone marrow niche into a self-reinforcing leukemic niche

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Uncertainty in the niches that maintain haematopoietic stem cells

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Critical Role of Thrombopoietin in Maintaining Adult Quiescent Hematopoietic Stem Cells

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Analysis of histone 2B-GFP retention reveals slowly cycling hematopoietic stem cells

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Induction of the chemokine stromal-derived factor-1 following DNA damage improves human stem cell function

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Detection of functional haematopoietic stem cell niche using real-time imaging

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Quantitative imaging of haematopoietic stem and progenitor cell localization and hypoxic status in the bone marrow microenvironment

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A Microenvironment-Induced Myeloproliferative Syndrome Caused by Retinoic Acid Receptor γ Deficiency

Walkley, C. R., Olsen, G. H., Dworkin, S., Fabb, S. A., Swann, J. B., McArthur, G. A., Westmoreland, S. V., Chambon, P., Scadden, D. T., & Purton, L. E. (2007) · Cell · doi:10.1016/j.cell.2007.05.014 · Cited by 535

Wnt Signaling in the Niche Enforces Hematopoietic Stem Cell Quiescence and Is Necessary to Preserve Self-Renewal In Vivo

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PDGFRα and CD51 mark human Nestin+ sphere-forming mesenchymal stem cells capable of hematopoietic progenitor cell expansion

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Immune targeting of fibroblast activation protein triggers recognition of multipotent bone marrow stromal cells and cachexia

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Heterogeneity and hierarchy within the most primitive hematopoietic stem cell compartment

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Vascular niche E-selectin regulates hematopoietic stem cell dormancy, self renewal and chemoresistance

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CD169 + macrophages provide a niche promoting erythropoiesis under homeostasis and stress

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Efficient Transplantation via Antibody-Based Clearance of Hematopoietic Stem Cell Niches

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Endochondral ossification is required for haematopoietic stem-cell niche formation

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Depletion of stromal cells expressing fibroblast activation protein-α from skeletal muscle and bone marrow results in cachexia and anemia

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Rb Regulates Interactions between Hematopoietic Stem Cells and Their Bone Marrow Microenvironment

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Haematopoietic stem cells do not asymmetrically segregate chromosomes or retain BrdU

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Human osteoblasts support hematopoiesis through the production of granulocyte colony-stimulating factor.

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CXCR4 is required for the quiescence of primitive hematopoietic cells

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Osteoblasts support B-lymphocyte commitment and differentiation from hematopoietic stem cells

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Angiocrine factors from Akt-activated endothelial cells balance self-renewal and differentiation of haematopoietic stem cells

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Hematopoietic stem cell deficiencies in mice lacking c-Mpl, the receptor for thrombopoietin

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The relative spatial distributions of CFUs and CFUc in the normal mouse femur

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