Cited by 2,451Hematopoietic Stem Cell TransplantationMesenchymal stem cell researchMultiple Myeloma Research and Treatments

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The bone marrow niche for haematopoietic stem cells

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Morrison, Sean J., Scadden, David T.·2014·Nature

DOI 10.1038/nature12984PMC PMC4514480

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Abstract

Niches are local tissue microenvironments that maintain and regulate stem cells. Haematopoiesis provides a model for understanding mammalian stem cells and their niches, but the haematopoietic stem cell (HSC) niche remains incompletely defined and beset by competing models. Recent progress has been made in elucidating the location and cellular components of the HSC niche in the bone marrow. The niche is perivascular, created partly by mesenchymal stromal cells and endothelial cells and often, but not always, located near trabecular bone. Outstanding questions concern the cellular complexity of the niche, the role of the endosteum and functional heterogeneity among perivascular microenvironments.

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Authors: Morrison, S. J., & Scadden, D. T.
Affiliations: Howard Hughes Medical Institute (US)
Harvard University (US)
Corresponding author: Morrison, Sean J.
Scadden, David T.
ORCID: Morrison, Sean J.
Scadden, David T.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2014-01
Volume: 505
Issue: 7483
Pages: 327-334
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature12984
PMC: PMC4514480
OpenAlex: W2149053153
Semantic Scholar: 63cdd906a38c49f8d452a64cb77d5a597cfbfb38
Cited by: 2,451
References: 130
Citations by year: 2026: 139 · 2025: 176 · 2024: 141 · 2023: 177 · 2022: 194 · 2021: 210 · 2020: 226 · 2019: 225 · 2018: 240 · 2017: 223 · 2016: 225 · 2015: 184 · 2014: 89
FWCI: 36.68
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Funders: Howard Hughes Medical Institute
National Heart, Lung, and Blood Institute (HL096372, R01HL044851, R03HL096372, HL044851, HL097760, R01HL097760)
National Institute of Biomedical Imaging and Bioengineering (R01EB014703, EB014703)
Topics: Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
Health Sciences › Medicine › Hematology › Multiple Myeloma Research and Treatments
Keywords: hematopoietic stem cells, bone marrow microenvironment, hematopoiesis, perivascular niche, mesenchymal stem cells, endothelial cells, trabecular bone, endosteum, stem cell niche
MeSH terms: Animals, Bone and Bones, Bone Marrow, Hematopoietic Stem Cells, Humans, Osteoblasts, Endothelial Cells, Stem Cell Niche, Mesenchymal Stem Cells

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The bone marrow niche for haematopoietic stem cells

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