The DOI matches its Crossref record; 130 of the 130 references it cites were found in a registry or an index.
The bone marrow niche for haematopoietic stem cells
Open accessAbstract
Niches are local tissue microenvironments that maintain and regulate stem cells. Haematopoiesis provides a model for understanding mammalian stem cells and their niches, but the haematopoietic stem cell (HSC) niche remains incompletely defined and beset by competing models. Recent progress has been made in elucidating the location and cellular components of the HSC niche in the bone marrow. The niche is perivascular, created partly by mesenchymal stromal cells and endothelial cells and often, but not always, located near trabecular bone. Outstanding questions concern the cellular complexity of the niche, the role of the endosteum and functional heterogeneity among perivascular microenvironments.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Non-haematopoietic stromal cells, including osteoblasts and osteoprogenitor cells, promote the maintenance of haematopoietic stem cells.95”
From The costs and benefits of senotherapeutics for human health (2022) · cites this paper as [95]
In the citing paper
“Other cell types that regulate HSC niches include osteoclasts, extracellular matrix, megakaryocytes, and calcium.9”
From Inflammatory bone marrow microenvironment (2019) · cites this paper as [9]
In the citing paper
“Although MSCs are a heterogeneous population and still require better characterization by surface markers, perivascular mesenchymal cells that express CD146 in humans and Cxcl12-green fluorescent protein, Nestin-green fluorescent protein, full-length Leptin receptor, Prx-1-Cre, Osterix-Cre, and inducible Mx-1-Cre in mice generate osteoblastic cells and express factors that promote the maintenance”
From Inflammatory bone marrow microenvironment (2019) · cites this paper as [9]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Targeting Hypoxia-Inducible Factors for the Treatment of Anemia in Chronic Kidney Disease Patients
Locatelli, F., Fishbane, S. N., Block, G. A., & Macdougall, I. C. (2017) · American Journal of Nephrology · doi:10.1159/000455166 · Cited by 4,836
Cytokine-mediated regulation of CXCR4 expression in human neutrophils
Nagase, H., Miyamasu, M., Yamaguchi, M., Imanishi, M., Tsuno, N. H., Matsushima, K., Yamamoto, K., Morita, Y., & Hirai, K. (2002) · Journal of Leukocyte Biology · doi:10.1189/jlb.71.4.711 · Cited by 4,713
A Direct Measurement of the Radiation Sensitivity of Normal Mouse Bone Marrow Cells1
Till, J. E., & McCulloch, E. A. (2010) · Radiation Research · doi:10.1667/rrxx28.1 · Cited by 4,036
A Direct Measurement of the Radiation Sensitivity of Normal Mouse Bone Marrow Cells
Till, J. E., & McCulloch, E. A. (1961) · Radiation Research · doi:10.2307/3570892 · Cited by 3,848
Osteoblastic cells regulate the haematopoietic stem cell niche
Calvi, L. M., Adams, G. B., Weibrecht, K. W., Weber, J. M., Olson, D. P., Knight, M. C., Martin, R. P., Schipani, E., Pajevic, P. D., Bringhurst, F. R., et al. (2003) · Nature · doi:10.1038/nature02040 · Cited by 3,559
Self-citationMesenchymal and haematopoietic stem cells form a unique bone marrow niche
Méndez‐Ferrer, S., Michurina, T. V., Ferraro, F., Mazloom, A. R., MacArthur, B. D., Lira, S. A., Scadden, D. T., Ma’ayan, A., Enikolopov, G., & Frenette, P. S. (2010) · Nature · doi:10.1038/nature09262 · Cited by 3,381
Self-citationKiel, M. J., Yilmaz, Ö. H., Iwashita, T., Yilmaz, O. H., Terhorst, C., & Morrison, S. J. (2005) · Cell · doi:10.1016/j.cell.2005.05.026 · Cited by 3,168
Self-citationIdentification of the haematopoietic stem cell niche and control of the niche size
Zhang, J., Niu, C. S., Ye, L., Huang, H., He, X. C., Tong, W.-G., Ross, J., Haug, J., Johnson, T. J., Feng, J. Q., et al. (2003) · Nature · doi:10.1038/nature02041 · Cited by 2,948
Purification and Characterization of Mouse Hematopoietic Stem Cells
Spangrude, G. J., Heimfeld, S., & Weissman, I. L. (1988) · Science · doi:10.1126/science.2898810 · Cited by 2,908
Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development
Zou, Y.-R., Kottmann, A. H., Kuroda, M., Taniuchi, I., & Littman, D. R. (1998) · Nature · doi:10.1038/31269 · Cited by 2,531
Cited by
Sorted by citations
Items 201–300 of 1,005
Mahadik, B. P., Pedrón, S., Skertich, L. J., & Harley, B. A. C. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2015.07.042 · Cited by 119
Endothelial-to-haematopoietic transition: an update on the process of making blood
Ottersbach, K. (2019) · Biochemical Society Transactions · doi:10.1042/bst20180320 · Cited by 116
Mok, K., Saxena, N., Heitman, N., Grisanti, L., Srivastava, D., Muraro, M. J., Jacob, T., Sennett, R., Wang, Z., Su, Y., et al. (2018) · Developmental Cell · doi:10.1016/j.devcel.2018.11.034 · Cited by 110
Osteoclasts protect bone blood vessels against senescence through the angiogenin/plexin-B2 axis
Liu, X., Chai, Y., Liu, G., Su, W., Guo, Q., Lv, X., Gao, P., Yu, B., Ferbeyre, G., Cao, X., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-22131-1 · Cited by 116
Liu, F., Li, D., Yu, Y. Y. L., Kang, I., Cha, M., Kim, J. Y., Park, C., Watson, D. K., Wang, T., & Choi, K. (2015) · EMBO Reports · doi:10.15252/embr.201439939 · Cited by 117
Chasing the recipe for a pro-regenerative immune system
Godwin, J. W., Pinto, A. R., & Rosenthal, N. A. (2016) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2016.08.008 · Cited by 117
von der Heide, E. K., Neumann, M., Vosberg, S., James, A. R., Schroeder, M. P., Ortiz-Tánchez, J., Isaakidis, K., Schlee, C., Luther, M., Jöhrens, K., et al. (2016) · Leukemia · doi:10.1038/leu.2016.324 · Cited by 114
Origin and differentiation trajectories of fibroblastic reticular cells in the splenic white pulp
Cheng, H., Onder, L., Novković, M., Soneson, C., Lütge, M., Pikor, N. B., Scandella, E., Robinson, M. D., Miyazaki, J., Tersteegen, A., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-09728-3 · Cited by 111
Regulating trained immunity with nanomedicine
van Leent, M. M. T., Priem, B., Schrijver, D. P., de Dreu, A., Hofstraat, S. R. J., Zwolsman, R. C., Beldman, T. J., Netea, M. G., & Mulder, W. J. M. (2022) · Nature Reviews Materials · doi:10.1038/s41578-021-00413-w · Cited by 117
Limited rejuvenation of aged hematopoietic stem cells in young bone marrow niche
Kuribayashi, W., Oshima, M., Itokawa, N., Koide, S., Nakajima-Takagi, Y., Yamashita, M., Yamazaki, S., Rahmutulla, B., Miura, F., Ito, T., et al. (2021) · Journal of Experimental Medicine · doi:10.1084/jem.20192283 · Cited by 111
Interleukin-1β suppression dampens inflammatory leucocyte production and uptake in atherosclerosis
Hettwer, J., Hinterdobler, J., Miritsch, B., Deutsch, M.-A., Li, X., Mauersberger, C., Moggio, A., Braster, Q., Gram, H., Robertson, A. A. B., et al. (2021) · Cardiovascular Research · doi:10.1093/cvr/cvab337 · Cited by 118
Structure and Functions of Blood Vessels and Vascular Niches in Bone
Ramasamy, S. K. (2017) · Stem Cells International · doi:10.1155/2017/5046953 · Cited by 125
Zhang, S., Ma, B., Liu, F., Duan, J., Wang, S., Qiu, J., Li, D., Sang, Y., Liu, C., Liu, D., et al. (2018) · Nano Letters · doi:10.1021/acs.nanolett.7b04747 · Cited by 110
Jasso, G. J., Jaiswal, A., Varma, M., Laszewski, T., Grauel, A. L., Omar, A. S., Silva, N., Dranoff, G., Porter, J. A., Mansfield, K. G., et al. (2022) · PLoS Biology · doi:10.1371/journal.pbio.3001532 · Cited by 114
Liu, H., Cheng, J., Chen, F., Bai, D., Shao, C., Wang, J., Xi, P., & Zeng, Z. (2014) · Nanoscale · doi:10.1039/c4nr00355a · Cited by 110
Ginaldi, L., & Martinis, M. D. (2016) · Current Medicinal Chemistry · doi:10.2174/0929867323666160907162546 · Cited by 111
Tissue-specific immunopathology during malaria infection
Coban, C., Lee, M. S. J., & Ishii, K. J. (2018) · Nature reviews. Immunology · doi:10.1038/nri.2017.138 · Cited by 111
Bone Metastasis: Find Your Niche and Fit in
Zhang, W., Bado, I., Wang, H., Lo, H.-C., & Zhang, X. H.-F. (2019) · Trends in cancer · doi:10.1016/j.trecan.2018.12.004 · Cited by 110
Sun, C., Wang, L., Wang, H., Huang, T., Yao, W., Li, J., & Zhang, X. (2020) · Stem Cell Research & Therapy · doi:10.1186/s13287-020-01660-4 · Cited by 108
The hematopoietic stem-cell niche in health and leukemia
Sánchez‐Aguilera, A., & Méndez‐Ferrer, S. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2306-y · Cited by 119
Buduo, C. A. D., Currao, M., Pecci, A., Kaplan, D. L., Balduini, C. L., & Balduini, A. (2016) · Haematologica · doi:10.3324/haematol.2016.146746 · Cited by 106
Modifiable Cardiovascular Risk, Hematopoiesis, and Innate Immunity
Schloss, M. J., Świrski, F. K., & Nahrendorf, M. (2020) · Circulation Research · doi:10.1161/circresaha.120.315936 · Cited by 114
Sepsis promotes splenic production of a protective platelet pool with high CD40 ligand expression
Valet, C., Magnen, M., Qiu, L., Cleary, S. J., Wang, K. M., Ranucci, S., Grockowiak, É., Boudra, R., Conrad, C., Seo, Y., et al. (2022) · Journal of Clinical Investigation · doi:10.1172/jci153920 · Cited by 108
Regulation of leucocyte homeostasis in the circulation
Scheiermann, C., Frenette, P. S., & Hidalgo, A. (2015) · Cardiovascular Research · doi:10.1093/cvr/cvv099 · Cited by 108
Hardwiring Stem Cell Communication through Tissue Structure
Xin, T., Greco, V., & Myung, P. S. (2016) · Cell · doi:10.1016/j.cell.2016.02.041 · Cited by 106
The Components of Bone and What They Can Teach Us about Regeneration
Le, B. Q., Nurcombe, V., Cool, S. M., van Blitterswijk, C., de Boer, J., & LaPointe, V. L. S. (2017) · Materials · doi:10.3390/ma11010014 · Cited by 113
Mitochondrial Role in Stemness and Differentiation of Hematopoietic Stem Cells
Papa, L., Djedaini, M., & Hoffman, R. (2019) · Stem Cells International · doi:10.1155/2019/4067162 · Cited by 108
The neurotrophic factor receptor RET drives haematopoietic stem cell survival and function
Fonseca‐Pereira, D., Arroz‐Madeira, S., Rodrigues-Campos, M., Barbosa, I. A. M., Domingues, R. G., Bento, T., Almeida, A. R. M., Ribeiro, H., Potocnik, A. J., Enomoto, H., et al. (2014) · Nature · doi:10.1038/nature13498 · Cited by 103
Chen, X., Deng, H., Churchill, M., Luchsinger, L. L., Du, X., Chu, T. H., Friedman, R. A., Middelhoff, M. A., Ding, H., Tailor, Y. H., et al. (2017) · Cell stem cell · doi:10.1016/j.stem.2017.11.003 · Cited by 103
A hostel for the hostile: the bone marrow niche in hematologic neoplasms
Krause, D. S., & Scadden, D. T. (2015) · Haematologica · doi:10.3324/haematol.2014.113852 · Cited by 104
Self-citationTo wake up cancer stem cells, or to let them sleep, that is the question
Takeishi, S., & Nakayama, K. I. (2016) · Cancer Science · doi:10.1111/cas.12958 · Cited by 103
Prospective Isolation and Characterization of Genetically and Functionally Distinct AML Subclones
de Boer, B., Prick, J. C. M., Pruis, M. G. M., Keane, P., Imperato, M. R., Jaques, J., Brouwers-Vos, A. Z., Hogeling, S. M., Woolthuis, C. M., Nijk, M. T., et al. (2018) · Cancer Cell · doi:10.1016/j.ccell.2018.08.014 · Cited by 101
Acute Myeloid Leukemia and the Bone Marrow Niche—Take a Closer Look
Behrmann, L., Wellbrock, J., & Fiedler, W. (2018) · Frontiers in Oncology · doi:10.3389/fonc.2018.00444 · Cited by 108
Secreted protein Del-1 regulates myelopoiesis in the hematopoietic stem cell niche
Mitroulis, I., Chen, L., Singh, R. P., Kourtzelis, I., Economopoulou, M., Kajikawa, T., Troullinaki, M., Ziogas, A., Ruppova, K., Hosur, K. B., et al. (2017) · Journal of Clinical Investigation · doi:10.1172/jci92571 · Cited by 101
Louradour, I., Sharma, A., Morin-Poulard, I., Letourneau, M., Vincent, A., Crozatier, M., & Vanzo, N. F. (2017) · eLife · doi:10.7554/elife.25496 · Cited by 101
The role of interferon-gamma in hematopoietic stem cell development, homeostasis, and disease
Morales-Mantilla, D. E., & King, K. Y. (2018) · Current Stem Cell Reports · doi:10.1007/s40778-018-0139-3 · Cited by 99
Golan, K., Singh, A. K., Kollet, O., Bertagna, M., Althoff, M. J., Khatib-Massalha, E., Petrovich-Kopitman, E., Wellendorf, A. M., Massalha, H., Levin-Zaidman, S., et al. (2020) · Blood · doi:10.1182/blood.2020005399 · Cited by 99
Engineering a haematopoietic stem cell niche by revitalizing mesenchymal stromal cells
Nakahara, F., Borger, D. K., Wei, Q., Pinho, S., Maryanovich, M., Zahalka, A. H., Suzuki, M., Cruz, C. D., Wang, Z., Xu, C., et al. (2019) · Nature Cell Biology · doi:10.1038/s41556-019-0308-3 · Cited by 99
Identification of Meflin as a Potential Marker for Mesenchymal Stromal Cells
Maeda, K., Enomoto, A., Hara, A., Asai, N., Kobayashi, T., Horinouchi, A., Maruyama, S., Ishikawa, Y., Nishiyama, T., Kiyoi, H., et al. (2016) · Scientific Reports · doi:10.1038/srep22288 · Cited by 99
Zhang, J., & Link, D. C. (2016) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2877 · Cited by 99
Guo, B., Huang, X.-X., Cooper, S., & Broxmeyer, H. (2017) · Nature Medicine · doi:10.1038/nm.4298 · Cited by 90
Granulocyte-derived TNFα promotes vascular and hematopoietic regeneration in the bone marrow
Bowers, E., Slaughter, A., Frenette, P. S., Kuick, R. D., Pello, Ó. M., & Lucas, D. (2017) · Nature Medicine · doi:10.1038/nm.4448 · Cited by 98
Extracellular vesicles in the hematopoietic microenvironment
Butler, J. T., Abdelhamed, S., & Kurre, P. (2018) · Haematologica · doi:10.3324/haematol.2017.183335 · Cited by 100
A Multi-Niche Microvascularized Human Bone-Marrow-on-a-Chip
Nelson, M. R., Ghoshal, D., Mejías, J. C., Rubio, D. A. F., Keith, E., & Roy, K. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2021.120683 · Cited by 105
Cellular players of hematopoietic stem cell mobilization in the bone marrow niche
Tay, J., Lévesque, J.-P., & Winkler, I. G. (2016) · International Journal of Hematology · doi:10.1007/s12185-016-2162-4 · Cited by 107
Bone Marrow Niches of Hematopoietic Stem and Progenitor Cells
Kandarakov, O. F., Belyavsky, A. V., & Semenova, E. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23084462 · Cited by 107
Role of Microenvironment in Resistance to Therapy in AML
Tabe, Y., & Konopleva, M. Y. (2015) · Current Hematologic Malignancy Reports · doi:10.1007/s11899-015-0253-6 · Cited by 101
Bone marrow as a metastatic niche for disseminated tumor cells from solid tumors
Shiozawa, Y., Eber, M. R., Berry, J. E., & Taichman, R. S. (2015) · BoneKEy Reports · doi:10.1038/bonekey.2015.57 · Cited by 98
Engineering the hematopoietic stem cell niche: Frontiers in biomaterial science
Choi, J. S., Mahadik, B. P., & Harley, B. A. C. (2015) · Biotechnology Journal · doi:10.1002/biot.201400758 · Cited by 98
Q&A: Mesenchymal stem cells — where do they come from and is it important?
Murray, I. R., & Péault, B. (2015) · BMC Biology · doi:10.1186/s12915-015-0212-7 · Cited by 97
Stem cells and the circadian clock
Weger, M., Diotel, N., Dorsemans, A.-C., Dickmeis, T., & Weger, B. D. (2017) · Developmental Biology · doi:10.1016/j.ydbio.2017.09.012 · Cited by 101
Kokkaliaris, K. D., Kunz, L., Cabezas‐Wallscheid, N., Christodoulou, C., Renders, S., Camargo, F. D., Trumpp, A., Scadden, D. T., & Schroeder, T. (2020) · Blood · doi:10.1182/blood.2020006574 · Cited by 93
Self-citationNicolay, N. H., Perez, R. L., Saffrich, R., & Huber, P. E. (2015) · Oncotarget · doi:10.18632/oncotarget.4358 · Cited by 98
Berry, D. C., Jiang, Y., & Graff, J. M. (2016) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2016.05.001 · Cited by 100
Dual cholinergic signals regulate daily migration of hematopoietic stem cells and leukocytes
García‐García, A., Korn, C., García-Fernández, M., Domingues, O., Villadiego, J., Martín-Pérez, D., Isern, J., Bejarano-García, J. A., Zimmer, J., Pérez‐Simón, J. A., et al. (2018) · Blood · doi:10.1182/blood-2018-08-867648 · Cited by 100
PEG/HA Hybrid Hydrogels for Biologically and Mechanically Tailorable Bone Marrow Organoids
Vallmajó-Martín, Q., Broguière, N., Millan, C., Zenobi‐Wong, M., & Ehrbar, M. (2020) · Advanced Functional Materials · doi:10.1002/adfm.201910282 · Cited by 99
Nahrendorf, M., & Swirski, F. K. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehv453 · Cited by 95
Bone marrow endothelial dysfunction promotes myeloid cell expansion in cardiovascular disease
Rohde, D., Vandoorne, K., Lee, I., Grune, J., Zhang, S., McAlpine, C. S., Schloss, M. J., Nayar, R., Courties, G., Frodermann, V., et al. (2021) · Nature Cardiovascular Research · doi:10.1038/s44161-021-00002-8 · Cited by 100
Self-citationAging-induced IL27Ra signaling impairs hematopoietic stem cells
He, H., Xu, P., Zhang, X., Liao, M., Dong, Q., Cong, T., Tang, B., Yang, X., Ye, M., Chang, Y., et al. (2020) · Blood · doi:10.1182/blood.2019003910 · Cited by 94
Schulenburg, A., Blatt, K., Cerny‐Reiterer, S., Sadovnik, I., Herrmann, H., Marian, B., Grunt, T. W., Zielinski, C. C., & Valent, P. (2015) · Journal of Hematology & Oncology · doi:10.1186/s13045-015-0113-9 · Cited by 95
Factors Affecting Early Antibody Secreting Cell Maturation Into Long-Lived Plasma Cells
Nguyen, D. C., Joyner, C. J., Sanz, I., & Lee, F. E.-H. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02138 · Cited by 97
Skeletal interoception in bone homeostasis and pain
Lv, X., Gao, F., & Cao, X. (2022) · Cell Metabolism · doi:10.1016/j.cmet.2022.09.025 · Cited by 94
Hematopoietic stem cell fate through metabolic control
Ito, K., & Ito, K. (2018) · Experimental Hematology · doi:10.1016/j.exphem.2018.05.005 · Cited by 98
Tajer, P., Pike‐Overzet, K., Arias, S., Havenga, M. J. E., & Staal, F. J. T. (2019) · Cells · doi:10.3390/cells8020169 · Cited by 98
PU.1 enforces quiescence and limits hematopoietic stem cell expansion during inflammatory stress
Chavez, J. S., Rabe, J. L., Loeffler, D., Higa, K. C., Hernandez, G., Mills, T. S., Ahmed, N., Gessner, R. L., Ke, Z., Idler, B. M., et al. (2021) · Journal of Experimental Medicine · doi:10.1084/jem.20201169 · Cited by 91
“, 2020), and signals generated from the bone marrow (BM) niche (Morrison and Scadden, 2014).”
BackgroundAngiocrine signals regulate quiescence and therapy resistance in bone metastasis
Singh, A., Veeriah, V., Xi, P., Labella, R., Chen, J., Romeo, S. G., Ramasamy, S. K., & Kusumbe, A. P. (2019) · JCI Insight · doi:10.1172/jci.insight.125679 · Cited by 93
Bakhtiyari, M., Liaghat, M., Aziziyan, F., Shapourian, H., Yahyazadeh, S., Alipour, M., Shahveh, S., Maleki‐Sheikhabadi, F., Halimi, H., Forghaniesfidvajani, R., et al. (2023) · Cell Communication and Signaling · doi:10.1186/s12964-023-01282-2 · Cited by 93
Niwa, O., Barcellos‐Hoff, M. H., Globus, R. K., Harrison, J. D., Hendry, J. H., Jacob, P., Martin, M. T., Seed, T. M., Shay, J. W., Story, M. D., et al. (2015) · Annals of the ICRP · doi:10.1177/0146645315595585 · Cited by 91
Niche derived netrin-1 regulates hematopoietic stem cell dormancy via its receptor neogenin-1
Renders, S., Svendsen, A. F., Panten, J., Rama, N., Maryanovich, M., Sommerkamp, P., Ladel, L., Redavid, A. R., Gibert, B., Lazare, S., et al. (2021) · Nature Communications · doi:10.1038/s41467-020-20801-0 · Cited by 97
Mesenchymal stem cell aging: Mechanisms and influences on skeletal and non-skeletal tissues
Liu, H., Xia, X., & Li, B. (2015) · Experimental Biology and Medicine · doi:10.1177/1535370215591828 · Cited by 91
Foxp3+ regulatory T cells maintain the bone marrow microenvironment for B cell lymphopoiesis
Pierini, A., Nishikii, H., Baker, J. B., Kimura, T., Kwon, H.-S., Pan, Y., Chen, Y., Álvarez, M., Strober, W. A., Velardi, A., et al. (2017) · Nature Communications · doi:10.1038/ncomms15068 · Cited by 87
Glucocorticoids Regulate Bone Marrow B Lymphopoiesis After Stroke
Courties, G., Frodermann, V., Honold, L., Zheng, Y. Z., Hérisson, F., Schloss, M. J., Sun, Y., Présumey, J., Sévère, N., Engblom, C., et al. (2019) · Circulation Research · doi:10.1161/circresaha.118.314518 · Cited by 87
Self-citationWilson, A., Webster, A., & Genever, P. G. (2019) · Regenerative Medicine · doi:10.2217/rme-2018-0145 · Cited by 87
Aleman, J., George, S. K., Herberg, S., Devarasetty, M., Porada, C. D., Skardal, A., & Almeida-Porada, G. D. (2019) · Small · doi:10.1002/smll.201902971 · Cited by 86
Regulation of stress-induced hematopoiesis
Zhao, J. L., & Baltimore, D. (2015) · Current Opinion in Hematology · doi:10.1097/moh.0000000000000149 · Cited by 97
Long Non-coding RNAs in Myeloid Malignancies
Zimța, A., Tomuleasa, C., Sahnoune, I., Calin, G. A., & Berindan‐Neagoe, I. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.01048 · Cited by 87
The extracellular matrix of hematopoietic stem cell niches
Lee‐Thedieck, C., Schertl, P., & Klein, G. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.114069 · Cited by 96
Origin of Cardiomyocytes in the Adult Heart
Leri, A., Rota, M., Pasqualini, F. S., Goichberg, P., & Anversa, P. (2014) · Circulation Research · doi:10.1161/circresaha.116.303595 · Cited by 89
Hypoxia and Bone Metastatic Disease
Johnson, R. W., Sowder, M. E., & Giaccia, A. J. (2017) · Current Osteoporosis Reports · doi:10.1007/s11914-017-0378-8 · Cited by 92
Naderi, E. H., Skah, S., Ugland, H. G., Myklebost, O., Sandnes, D., Torgersen, M. L., Josefsen, D., Ruud, E., Naderi, S., & Blomhoff, H. K. (2015) · Molecular Cancer · doi:10.1186/s12943-014-0278-9 · Cited by 85
Isolation and functional assessment of mouse skeletal stem cell lineage
Gulati, G. S., Murphy, M. P., Marecic, O., Lopez, M., Brewer, R. E., Koepke, L. S., Manjunath, A., Ransom, R. C., Salhotra, A., Weissman, I. L., et al. (2018) · Nature Protocols · doi:10.1038/nprot.2018.041 · Cited by 88
Multiple faces of succinate beyond metabolism in blood
Grimolizzi, F., & Arranz, L. (2018) · Haematologica · doi:10.3324/haematol.2018.196097 · Cited by 85
Neutrophils as regulators of the hematopoietic niche
Cossío, I., Lucas, D., & Hidalgo, A. (2019) · Blood · doi:10.1182/blood-2018-10-844571 · Cited by 88
Vascular Niche in Lung Alveolar Development, Homeostasis, and Regeneration
Mammoto, A., & Mammoto, T. (2019) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2019.00318 · Cited by 85
Liu, W., Chen, W., Xie, M., Chen, C., Shao, Z., Zhang, Y., Zhao, H., Song, Q., Hu, H., Xing, X., et al. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01457-w · Cited by 85
Mechanisms of marrow adiposity and its implications for skeletal health
Veldhuis-Vlug, A. G., & Rosen, C. J. (2017) · Metabolism · doi:10.1016/j.metabol.2016.11.013 · Cited by 71
3D models of the hematopoietic stem cell niche under steady-state and active conditions
Rödling, L., Schwedhelm, I., Kraus, S., Bieback, K., Hansmann, J., & Lee‐Thedieck, C. (2017) · Scientific Reports · doi:10.1038/s41598-017-04808-0 · Cited by 90
A gelatin hydrogel to study endometrial angiogenesis and trophoblast invasion
Zambuto, S. G., Clancy, K. B. H., & Harley, B. A. C. (2019) · Interface Focus · doi:10.1098/rsfs.2019.0016 · Cited by 83
Blood Vessels and Vascular Niches in Bone Development and Physiological Remodeling
Hendriks, M., & Ramasamy, S. K. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.602278 · Cited by 84
The journey from stem cell to macrophage
Pittet, M. J., Nahrendorf, M., & Świrski, F. K. (2014) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12393 · Cited by 89
Linkage between the mechanisms of thrombocytopenia and thrombopoiesis
Eto, K., & Kunishima, S. (2016) · Blood · doi:10.1182/blood-2015-07-607903 · Cited by 83
The stem cell division theory of cancer
López‐Lázaro, M. (2018) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2018.01.010 · Cited by 91
Winter, S., Shoaie, S., Kordasti, S. Y., & Platzbecker, U. (2020) · Journal of Clinical Oncology · doi:10.1200/jco.19.01823 · Cited by 82
Huang, C., Ness, V. P., Yang, X., Chen, H., Luo, J., Brown, E. B., & Zhang, X. (2015) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2460 · Cited by 83
Horiguchi, H., Kobune, M., Kikuchi, S., Yoshida, M., Murata, M., Murase, K., Iyama, S., Takada, K., Sato, T., Ono, K., et al. (2016) · Haematologica · doi:10.3324/haematol.2015.134932 · Cited by 89
Molecular mechanisms underlying lineage bias in aging hematopoiesis
Elias, H. K., Bryder, D., & Park, C. Y. (2016) · Seminars in Hematology · doi:10.1053/j.seminhematol.2016.11.002 · Cited by 80
Inflammatory bone marrow microenvironment
Leimkühler, N. B., & Schneider, R. K. (2019) · Hematology · doi:10.1182/hematology.2019000045 · Cited by 82
Numerous niches for hematopoietic stem cells remain empty during homeostasis
Shimoto, M., Sugiyama, T., & Nagasawa, T. (2017) · Blood · doi:10.1182/blood-2016-09-740563 · Cited by 82
Environmental Optimization Enables Maintenance of Quiescent Hematopoietic Stem Cells Ex Vivo
Kobayashi, H., Morikawa, T., Okinaga, A., Hamano, F., Hashidate‐Yoshida, T., Watanuki, S., Hishikawa, D., Shindou, H., Arai, F., Kabe, Y., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.06.008 · Cited by 87
Li, R., Lin, S., Zhu, M., Deng, Y., Chen, X., Wei, K., Xu, J., Li, G., & Bian, L. (2019) · Science Advances · doi:10.1126/sciadv.aaw3896 · Cited by 82
Metadata
- Authors
- Morrison, S. J., & Scadden, D. T.
- Affiliations
- Howard Hughes Medical Institute (US)
- Harvard University (US)
- Corresponding author
- Morrison, Sean J.
- Scadden, David T.
- Venue
- Nature
- Published
- 2014-01
- Volume
- 505
- Issue
- 7483
- Pages
- 327-334
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC4514480
- OpenAlex
- W2149053153
- Semantic Scholar
- 63cdd906a38c49f8d452a64cb77d5a597cfbfb38
- Cited by
- 2,451
- References
- 130
- Citations by year
- 2026: 139 · 2025: 176 · 2024: 141 · 2023: 177 · 2022: 194 · 2021: 210 · 2020: 226 · 2019: 225 · 2018: 240 · 2017: 223 · 2016: 225 · 2015: 184 · 2014: 89
- FWCI
- 36.68
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- Howard Hughes Medical Institute
- National Heart, Lung, and Blood Institute (HL096372, R01HL044851, R03HL096372, HL044851, HL097760, R01HL097760)
- National Institute of Biomedical Imaging and Bioengineering (R01EB014703, EB014703)
- Topics
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
- Health Sciences › Medicine › Hematology › Multiple Myeloma Research and Treatments
- Keywords
- hematopoietic stem cells, bone marrow microenvironment, hematopoiesis, perivascular niche, mesenchymal stem cells, endothelial cells, trabecular bone, endosteum, stem cell niche
- MeSH terms
- Animals, Bone and Bones, Bone Marrow, Hematopoietic Stem Cells, Humans, Osteoblasts, Endothelial Cells, Stem Cell Niche, Mesenchymal Stem Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
