Cited by 2,451Hematopoietic Stem Cell TransplantationMesenchymal stem cell researchMultiple Myeloma Research and Treatments

The DOI matches its Crossref record; 130 of the 130 references it cites were found in a registry or an index.

The bone marrow niche for haematopoietic stem cells

Open access

Morrison, Sean J., Scadden, David T.·2014·Nature

DOI 10.1038/nature12984PMC PMC4514480

Open this paper in CoChat — free account

Abstract

Niches are local tissue microenvironments that maintain and regulate stem cells. Haematopoiesis provides a model for understanding mammalian stem cells and their niches, but the haematopoietic stem cell (HSC) niche remains incompletely defined and beset by competing models. Recent progress has been made in elucidating the location and cellular components of the HSC niche in the bone marrow. The niche is perivascular, created partly by mesenchymal stromal cells and endothelial cells and often, but not always, located near trabecular bone. Outstanding questions concern the cellular complexity of the niche, the role of the endosteum and functional heterogeneity among perivascular microenvironments.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1038/nature12984

Cites

130 of 130 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Targeting Hypoxia-Inducible Factors for the Treatment of Anemia in Chronic Kidney Disease Patients
Locatelli, F., Fishbane, S. N., Block, G. A., & Macdougall, I. C. (2017) · American Journal of Nephrology · doi:10.1159/000455166 · Cited by 4,836
Cytokine-mediated regulation of CXCR4 expression in human neutrophils
Nagase, H., Miyamasu, M., Yamaguchi, M., Imanishi, M., Tsuno, N. H., Matsushima, K., Yamamoto, K., Morita, Y., & Hirai, K. (2002) · Journal of Leukocyte Biology · doi:10.1189/jlb.71.4.711 · Cited by 4,713
A Direct Measurement of the Radiation Sensitivity of Normal Mouse Bone Marrow Cells1
Till, J. E., & McCulloch, E. A. (2010) · Radiation Research · doi:10.1667/rrxx28.1 · Cited by 4,036
A Direct Measurement of the Radiation Sensitivity of Normal Mouse Bone Marrow Cells
Till, J. E., & McCulloch, E. A. (1961) · Radiation Research · doi:10.2307/3570892 · Cited by 3,848
Osteoblastic cells regulate the haematopoietic stem cell niche
Calvi, L. M., Adams, G. B., Weibrecht, K. W., Weber, J. M., Olson, D. P., Knight, M. C., Martin, R. P., Schipani, E., Pajevic, P. D., Bringhurst, F. R., et al. (2003) · Nature · doi:10.1038/nature02040 · Cited by 3,559
Self-citation
Mesenchymal and haematopoietic stem cells form a unique bone marrow niche
Méndez‐Ferrer, S., Michurina, T. V., Ferraro, F., Mazloom, A. R., MacArthur, B. D., Lira, S. A., Scadden, D. T., Ma’ayan, A., Enikolopov, G., & Frenette, P. S. (2010) · Nature · doi:10.1038/nature09262 · Cited by 3,381
Self-citation
SLAM Family Receptors Distinguish Hematopoietic Stem and Progenitor Cells and Reveal Endothelial Niches for Stem Cells
Kiel, M. J., Yilmaz, Ö. H., Iwashita, T., Yilmaz, O. H., Terhorst, C., & Morrison, S. J. (2005) · Cell · doi:10.1016/j.cell.2005.05.026 · Cited by 3,168
Self-citation
Identification of the haematopoietic stem cell niche and control of the niche size
Zhang, J., Niu, C. S., Ye, L., Huang, H., He, X. C., Tong, W.-G., Ross, J., Haug, J., Johnson, T. J., Feng, J. Q., et al. (2003) · Nature · doi:10.1038/nature02041 · Cited by 2,948
Purification and Characterization of Mouse Hematopoietic Stem Cells
Spangrude, G. J., Heimfeld, S., & Weissman, I. L. (1988) · Science · doi:10.1126/science.2898810 · Cited by 2,908
Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development
Zou, Y.-R., Kottmann, A. H., Kuroda, M., Taniuchi, I., & Littman, D. R. (1998) · Nature · doi:10.1038/31269 · Cited by 2,531

Flagged first, then by citations

Show all 130 references

Sorted by citations

Items 401–500 of 1,005

Smart Hydrogels for the Augmentation of Bone Regeneration by Endogenous Mesenchymal Progenitor Cell Recruitment
Lienemann, P. S., Vallmajó-Martín, Q., Papageorgiou, P., Blache, U., Metzger, S., Kivelio, A., Milleret, V., Sala, A., Hoehnel, S., Roch, A., et al. (2020) · Advanced Science · doi:10.1002/advs.201903395 · Cited by 66
Foxp3+ Regulatory T Cells in Bone and Hematopoietic Homeostasis
Fischer, L., Herkner, C., Kitte, R., Dohnke, S., Riewaldt, J., Kretschmer, K., & Garbe, A. I. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00578 · Cited by 64
VEGF-C protects the integrity of the bone marrow perivascular niche in mice
Fang, S., Chen, S., Nurmi, H. J., Leppänen, V., Jeltsch, M., Scadden, D. T., Silberstein, L., Mikkola, H. K. A., & Alitalo, K. K. (2020) · Blood · doi:10.1182/blood.2020005699 · Cited by 64
Self-citation
The CXCL12 Crossroads in Cancer Stem Cells and Their Niche
López-Gil, J. C., Martín-Hijano, L., Hermann, P. C., & Sáinz, B. (2021) · Cancers · doi:10.3390/cancers13030469 · Cited by 68
Emerging Non-Canonical Functions and Regulation by p53: p53 and Stemness
Olivos, D. J., & Mayo, L. D. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17121982 · Cited by 67
Understanding Hematopoietic Stem Cell Development through Functional Correlation of Their Proliferative Status with the Intra-aortic Cluster Architecture
Batsivari, A., Александрович, Р. С., Souilhol, C., Binagui-Casas, A., Hills, D., Zhao, S., Travers, P. J., & Medvinsky, A. (2017) · Stem Cell Reports · doi:10.1016/j.stemcr.2017.04.003 · Cited by 65
Atorvastatin enhances bone marrow endothelial cell function in corticosteroid-resistant immune thrombocytopenia patients
Kong, Y., Cao, X.-N., Zhang, X., Shi, M.-M., Lai, Y., Wang, Y., Xu, L., Chang, Y., & Huang, X. (2017) · Blood · doi:10.1182/blood-2017-09-807248 · Cited by 65
Stereotactic Ablative Radiation Therapy Induces Systemic Differences in Peripheral Blood Immunophenotype Dependent on Irradiated Site
McGee, H. M., Daly, M. E., Azghadi, S., STEWART, S. L., Oesterich, L. G., Schlom, J., Donahue, R. N., Schoenfeld, J. D., Chen, Q., Rao, S. S. D., et al. (2018) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2018.04.038 · Cited by 70
Imaging the Vascular Bone Marrow Niche During Inflammatory Stress
Vandoorne, K., Rohde, D., Kim, H.-Y., Courties, G., Wojtkiewicz, G. R., Honold, L., Hoyer, F. F., Frodermann, V., Nayar, R., Hérisson, F., et al. (2018) · Circulation Research · doi:10.1161/circresaha.118.313302 · Cited by 65
Harnessing organs-on-a-chip to model tissue regeneration
Tavakol, D. N., Fleischer, S., & Vunjak‐Novakovic, G. (2021) · Cell stem cell · doi:10.1016/j.stem.2021.05.008 · Cited by 68
The Immune Landscape of Osteosarcoma: Implications for Prognosis and Treatment Response
Cascini, C., & Chiodoni, C. (2021) · Cells · doi:10.3390/cells10071668 · Cited by 63
Immunometabolism in heart failure
Andreadou, I., Ghigo, A., Nikolaou, P., Świrski, F. K., Thackeray, J. T., Heusch, G., & Vilahur, G. (2025) · Nature Reviews Cardiology · doi:10.1038/s41569-025-01165-8 · Cited by 76
Regulation and consequences of monocytosis
Dutta, P., & Nahrendorf, M. (2014) · Immunological Reviews · doi:10.1111/imr.12219 · Cited by 66
Tunneling nanotubes mediate the transfer of stem cell marker CD133 between hematopoietic progenitor cells
Reichert, D., Scheinpflug, J., Karbanová, J., Freund, D., Bornhäuser, M., & Corbeil, D. (2016) · Experimental Hematology · doi:10.1016/j.exphem.2016.07.006 · Cited by 64
The aging hematopoietic stem cell niche: Phenotypic and functional changes and mechanisms that contribute to hematopoietic aging
Latchney, S. E., & Calvi, L. M. (2016) · Seminars in Hematology · doi:10.1053/j.seminhematol.2016.10.001 · Cited by 70
The Role of Nrf2 in the Response to Normal Tissue Radiation Injury
Cameron, B. D., Sekhar, K. R., Ofori, M., & Freeman, M. L. (2018) · Radiation Research · doi:10.1667/rr15059.1 · Cited by 63
Immune-Based Therapies in Acute Leukemia
Witkowski, M. T., Lasry, A., Carroll, W. L., & Aifantis, I. (2019) · Trends in cancer · doi:10.1016/j.trecan.2019.07.009 · Cited by 65
Hematopoietic Stem/Progenitor Cells and the Pathogenesis of HIV/AIDS
Tsukamoto, T. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.00060 · Cited by 63
AKR1C3 is a biomarker of sensitivity to PR-104 in preclinical models of T-cell acute lymphoblastic leukemia
Manesh, D. M., El‐Hoss, J., Evans, K., Richmond, J., Toscan, C. E., Bracken, L. S., Hedrick, A., Sutton, R., Marshall, G. M., Wilson, W. R., et al. (2015) · Blood · doi:10.1182/blood-2014-12-618900 · Cited by 63
Inflammation as a Keystone of Bone Marrow Stroma Alterations in Primary Myelofibrosis
Desterke, C., Martinaud, C., Ruzehaji, N., & Bousse‐Kerdilès, M. L. (2015) · Mediators of Inflammation · doi:10.1155/2015/415024 · Cited by 67
Regulating dynamic signaling between hematopoietic stem cells and niche cells via a hydrogel matrix
Mahadik, B. P., Bharadwaj, N. A., Ewoldt, R. H., & Harley, B. A. C. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.02.013 · Cited by 63
Here, There, and Anywhere? Arguments for and against the Physical Plasma Cell Survival Niche
Wilmore, J. R., & Allman, D. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1700461 · Cited by 63
Hematological alterations in protein malnutrition
Santos, E. W., de Oliveira, D. C., Silva, G. B., Tsujita, M., Beltran, J. S. D. O., Hastreiter, A. A., Fock, R. A., & Borelli, P. (2017) · Nutrition Reviews · doi:10.1093/nutrit/nux041 · Cited by 63
3D Immunocompetent Organ‐on‐a‐Chip Models
Maharjan, S., Cecen, B., & Zhang, Y. S. (2020) · Small Methods · doi:10.1002/smtd.202000235 · Cited by 62
Group 2 innate lymphoid cells support hematopoietic recovery under stress conditions
Sudo, T., Motomura, Y., Okuzaki, D., Hasegawa, T., Yokota, T., Kikuta, J., Ao, T., Mizuno, H., Matsui, T., Motooka, D., et al. (2021) · The Journal of Experimental Medicine · doi:10.1084/jem.20200817 · Cited by 61
Estrogen Receptor Functions and Pathways at the Vascular Immune Interface
Dama, A., Baggio, C., Boscaro, C., Albiero, M., & Cignarella, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22084254 · Cited by 62
Thrombopoietin/TGF-β1 Loop Regulates Megakaryocyte Extracellular Matrix Component Synthesis
Abbonante, V., Buduo, C. A. D., Gruppi, C., Malara, A., Gianelli, U., Celesti, G., Anselmo, A., Laghi, L., Vercellino, M., Visai, L., et al. (2016) · Stem Cells · doi:10.1002/stem.2285 · Cited by 69
The importance of hypoxia and extra physiologic oxygen shock/stress for collection and processing of stem and progenitor cells to understand true physiology/pathology of these cells ex vivo
Broxmeyer, H. E., O’Leary, H. A., Huang, X., & Mantel, C. (2015) · Current Opinion in Hematology · doi:10.1097/moh.0000000000000144 · Cited by 65
Uncovering the emergence of HSCs in the human fetal bone marrow by single-cell RNA-seq analysis
Zheng, Z., He, H., Tang, X. T., Zhang, H., Gou, F., Yang, H. Q., Cao, J., Shi, S., Yang, Z., Sun, G., et al. (2022) · Cell stem cell · doi:10.1016/j.stem.2022.10.005 · Cited by 61
Vascular control of the Drosophila haematopoietic microenvironment by Slit/Robo signalling
Morin-Poulard, I., Sharma, A., Louradour, I., Vanzo, N. F., Vincent, A., & Crozatier, M. (2016) · Nature Communications · doi:10.1038/ncomms11634 · Cited by 61
Bone Density Loss Is Associated With Blood Cell Counts
Valderrábano, R. J., Lui, L., Lee, J. S., Cummings, S. R., ORWOLL, E. S., Hoffman, A. R., & Wu, J. Y. (2016) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.3000 · Cited by 61
One-Dimensional Hydroxyapatite Nanostructures with Tunable Length for Efficient Stem Cell Differentiation Regulation
Ma, B., Zhang, S., Liu, F., Duan, J., Wang, S., Han, J., Sang, Y., Yu, X., Li, D., Tang, W., et al. (2017) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.7b13313 · Cited by 61
Leukemia-Initiating Cells in T-Cell Acute Lymphoblastic Leukemia
Tan, S. H., Bertulfo, F. C., & Sanda, T. (2017) · Frontiers in Oncology · doi:10.3389/fonc.2017.00218 · Cited by 61
Adrenergic Modulation of Hematopoiesis
Maestroni, G. J. M. (2019) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-019-09840-7 · Cited by 61
The frontier of live tissue imaging across space and time
Huang, Q., Garrett, A., Bose, S., Blocker, S. J., Rios, A. C., Clevers, H. C., & Shen, X. (2021) · Cell stem cell · doi:10.1016/j.stem.2021.02.010 · Cited by 60
Current insights into the bone marrow niche: From biology in vivo to bioengineering ex vivo
Xiao, Y., McGuinness, C. S., Doherty-Boyd, W. S., Salmerón‐Sánchez, M., Donnelly, H., & Dalby, M. J. (2022) · Biomaterials · doi:10.1016/j.biomaterials.2022.121568 · Cited by 65
Macrophages: Key regulators of steady-state and demand-adapted hematopoiesis
McCabe, A. F., & MacNamara, K. C. (2016) · Experimental Hematology · doi:10.1016/j.exphem.2016.01.003 · Cited by 62
Pericytes, integral components of adult hematopoietic stem cell niches
da Bandeira, D. S., Casamitjana, J., & Crisan, M. (2016) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2016.11.006 · Cited by 62
Osteocyte regulation of bone and blood
Pajevic, P. D., & Krause, D. S. (2018) · Bone · doi:10.1016/j.bone.2018.02.012 · Cited by 63
Bone Marrow Adipocytes: The Enigmatic Components of the Hematopoietic Stem Cell Niche
Cuminetti, V., & Arranz, L. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8050707 · Cited by 62
Longitudinal Cytokine Profiling Identifies GRO‐α and EGF as Potential Biomarkers of Disease Progression in Essential Thrombocythemia
Øbro, N. F., Grinfeld, J., Belmonte, M., Irvine, M., Shepherd, M. S., Rao, T. N., Karow, A., Riedel, L. M., Harris, O. B., Baxter, E. J., et al. (2020) · HemaSphere · doi:10.1097/hs9.0000000000000371 · Cited by 58
Macrophages Orchestrate Hematopoietic Programs and Regulate HSC Function During Inflammatory Stress
Seyfried, A. N., Maloney, J., & MacNamara, K. C. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01499 · Cited by 61
Bone Marrow-Derived Mesenchymal Stromal Cells: A Novel Target to Optimize Hematopoietic Stem Cell Transplantation Protocols in Hematological Malignancies and Rare Genetic Disorders
Crippa, S., Santi, L., Bosotti, R., Porro, G., & Bernardo, M. E. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm9010002 · Cited by 59
Multiple myeloma hinders erythropoiesis and causes anaemia owing to high levels of CCL3 in the bone marrow microenvironment
Liu, L., Yu, Z., Cheng, H., Mao, X., Sui, W., Deng, S., Wei, X., Lv, J., Du, C., Xu, J., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-77450-y · Cited by 59
Aging is associated with functional and molecular changes in distinct hematopoietic stem cell subsets
Su, T.-Y., Hauenstein, J., Somuncular, E., Dumral, Ö., Leonard, E., Gustafsson, C., Tzortzis, E., Forlani, A., Johansson, A., Qian, H., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-52318-1 · Cited by 66
The hematopoietic system in the context of regenerative medicine
Porada, C. D., Atala, A., & Almeida-Porada, G. D. (2015) · Methods · doi:10.1016/j.ymeth.2015.08.015 · Cited by 61
M1 and M2 macrophages differentially regulate hematopoietic stem cell self-renewal and ex vivo expansion
Luo, Y., Shao, L., Chang, J., Feng, W., Liu, Y. L., Cottler‐Fox, M., Emanuel, P. D., Hauer‐Jensen, M., Bernstein, I. D., Liu, L., et al. (2018) · Blood Advances · doi:10.1182/bloodadvances.2018015685 · Cited by 59
Pro-inflammatory cytokine blockade attenuates myeloid expansion in a murine model of rheumatoid arthritis
Hernandez, G., Mills, T. S., Rabe, J. L., Chavez, J. S., Kuldanek, S., Kirkpatrick, G., Noetzli, L., Jubair, W. K., Zanche, M., Myers, J. R., et al. (2020) · Haematologica · doi:10.3324/haematol.2018.197210 · Cited by 58
Targeting mesenchymal stromal cells plasticity to reroute acute myeloid leukemia course
Borella, G., Ros, A. D., Borile, G., Porcù, E., Tregnago, C., Benetton, M., Marchetti, A., Bisio, V., Montini, B., Michielotto, B., et al. (2021) · Blood · doi:10.1182/blood.2020009845 · Cited by 58
The Molecular Signature of the Stroma Response in Prostate Cancer-Induced Osteoblastic Bone Metastasis Highlights Expansion of Hematopoietic and Prostate Epithelial Stem Cell Niches
Özdemir, B. C., Hensel, J., Secondini, C., Wetterwald, A., Schwaninger, R., Fleischmann, A., Raffelsberger, W., Poch, O., Delorenzi, M., Temanni, R., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0114530 · Cited by 59
Matrix metalloproteinases in stem cell mobilization
Klein, G., Schmal, O., & Aicher, W. K. (2015) · Matrix Biology · doi:10.1016/j.matbio.2015.01.011 · Cited by 58
Differences in Cell Cycle Status Underlie Transcriptional Heterogeneity in the HSC Compartment
Lauridsen, F. K. B., Jensen, T. L., Rapin, N., Aslan, D., Wilhelmson, A. S., Pundhir, S., Rehn, M., Paul, F., Giladi, A., Hasemann, M. S., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.06.057 · Cited by 56
Transmissible ER stress reconfigures the AML bone marrow compartment
Doron, B., Abdelhamed, S., Butler, J. T., Hashmi, S. K., Horton, T. M., & Kurre, P. (2018) · Leukemia · doi:10.1038/s41375-018-0254-2 · Cited by 59
Potential therapeutic roles of stem cells in ischemia-reperfusion injury
Barzegar, M., Kaur, G., Gavins, F. N. E., Wang, Y., Boyer, C. J., & Alexander, J. S. (2019) · Stem Cell Research · doi:10.1016/j.scr.2019.101421 · Cited by 60
Protein quality control through endoplasmic reticulum-associated degradation maintains haematopoietic stem cell identity and niche interactions
Xu, L., Liu, X., Peng, F., Zhang, W., Zheng, L., Ding, Y., Gu, T., Lv, K., Wang, J., Ortinau, L. C., et al. (2020) · Nature Cell Biology · doi:10.1038/s41556-020-00581-x · Cited by 57
Developmental low-dose exposure to bisphenol A induces chronic inflammation, bone marrow fibrosis and reduces bone stiffness in female rat offspring only
Lind, T., Lejonklou, M. H., Dunder, L., Kushnir, M. M., Öhman‐Mägi, C., Larsson, S., Melhus, H., & Lind, P. (2019) · Environmental Research · doi:10.1016/j.envres.2019.108584 · Cited by 56
The Impact of Exercise on Immunity, Metabolism, and Atherosclerosis
Meyer-Lindemann, U., Moggio, A., Dutsch, A., Kessler, T., & Sager, H. B. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043394 · Cited by 62
Harnessing the Stem Cell Niche in Regenerative Medicine: Innovative Avenue to Combat Neurodegenerative Diseases
Velikic, G. S., Maric, D. M., Marić, D., Šupić, G., Puletić, M., Dulić, O., & Vojvodić, D. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25020993 · Cited by 63
Endoplasmic reticulum (ER) protein degradation by ER-associated degradation and ER-phagy
Wu, S. A., Li, Z. J., & Qi, L. (2025) · Trends in Cell Biology · doi:10.1016/j.tcb.2025.01.002 · Cited by 57
Wnt Signaling in Hematological Malignancies
Grainger, S. J., Traver, D. J., & Willert, K. (2017) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2017.11.002 · Cited by 56
Bone marrow lympho-myeloid malfunction in obesity requires precursor cell-autonomous TLR4
Liu, A., Chen, M., Kumar, R. J., Stefanović-Račić, M., O'Doherty, R. M., Ding, Y., Jahnen‐Dechent, W., & Borghesi, L. (2018) · Nature Communications · doi:10.1038/s41467-018-03145-8 · Cited by 59
Lysosomal Acid Lipase: From Cellular Lipid Handler to Immunometabolic Target
Gomaraschi, M., Bonacina, F., & Norata, G. D. (2019) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2018.12.006 · Cited by 58
Osteomacs interact with megakaryocytes and osteoblasts to regulate murine hematopoietic stem cell function
Mohamad, S. F., Xu, L., Ghosh, J., Childress, P. J., Abeysekera, I., Himes, E. R., Wu, H., Alvarez, M. B., Davis, K. M., Aguilar-Perez, A., et al. (2017) · Blood Advances · doi:10.1182/bloodadvances.2017011304 · Cited by 56
DNA Damage Response in Hematopoietic Stem Cell Ageing
Li, T., Zhou, Z., Ju, Z., & Wang, Z. (2016) · Genomics Proteomics & Bioinformatics · doi:10.1016/j.gpb.2016.04.002 · Cited by 56
Mesenchymal stromal/stem cells in drug therapy: New perspective
Sherman, L. S., Shaker, M., Mariotti, V., & Rameshwar, P. (2016) · Cytotherapy · doi:10.1016/j.jcyt.2016.09.007 · Cited by 58
Stromal Gli2 activity coordinates a niche signaling program for mammary epithelial stem cells
Zhao, C., Cai, S., Shin, K., Lim, A. Y.-L., Tomer Kalisky, C., Lu, W.-J., Clarke, M. F., & Beachy, P. A. (2017) · Science · doi:10.1126/science.aal3485 · Cited by 55
Highly multiplexed proteomic assessment of human bone marrow in acute myeloid leukemia
Çelik, H., Lindblad, K. E., Popescu, B. O., Gui, G., Goswami, M., Valdez, J., DeStefano, C. B., Lai, C., Thompson, J., Ghannam, J. Y., et al. (2020) · Blood Advances · doi:10.1182/bloodadvances.2019001124 · Cited by 56
Functional Niche Competition Between Normal Hematopoietic Stem and Progenitor Cells and Myeloid Leukemia Cells
Glait‐Santar, C., Desmond, R. G., Feng, X., Bat, T., Chen, J., Heuston, E. F., Mizukawa, B. E., Mulloy, J. C., Bodine, D. M., Larochelle, A., et al. (2015) · Stem Cells · doi:10.1002/stem.2208 · Cited by 55
Association between an Impaired Bone Marrow Vascular Microenvironment and Prolonged Isolated Thrombocytopenia after Allogeneic Hematopoietic Stem Cell Transplantation
Kong, Y., Hu, Y., Zhang, X., Wang, Y., Mo, X., Zhang, Y., Wang, Y., Han, W., Xu, L., Chang, Y., et al. (2014) · Transplantation and Cellular Therapy · doi:10.1016/j.bbmt.2014.04.015 · Cited by 55
JAK2V617F-mutant megakaryocytes contribute to hematopoietic stem/progenitor cell expansion in a model of murine myeloproliferation
Zhan, H., Ma, Y., Lin, C. H. S., & Kaushansky, K. (2016) · Leukemia · doi:10.1038/leu.2016.114 · Cited by 57
The Role of Extracellular Vesicle and Tunneling Nanotube-Mediated Intercellular Cross-Talk Between Mesenchymal Stem Cells and Human Peripheral T Cells
Matula, Z., Németh, A., Lőrincz, P., Szepesi, Á., Brózik, A., Buzás, E. I., Lőw, P., Német, K., Uher, F., & Urbán, V. S. (2016) · Stem Cells and Development · doi:10.1089/scd.2016.0086 · Cited by 55
Thyroid hormone receptor beta and NCOA4 regulate terminal erythrocyte differentiation
Gao, X., Lee, H., Li, W., Platt, R. J., Barrasa, M. I., Ma, Q., Elmes, R. R., Rosenfeld, M. G., & Lodish, H. F. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1711058114 · Cited by 55
Effects of Iron Overload and Oxidative Damage on the Musculoskeletal System in the Space Environment: Data from Spaceflights and Ground-Based Simulation Models
Yang, J., Zhang, G., Dong, D., & Shang, P. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19092608 · Cited by 54
“Caught in the net”: the extracellular matrix of the bone marrow in normal hematopoiesis and leukemia
Zanetti, C., & Krause, D. S. (2020) · Experimental Hematology · doi:10.1016/j.exphem.2020.07.010 · Cited by 51
Hepatic stellate and endothelial cells maintain hematopoietic stem cells in the developing liver
Lee, Y., Leslie, J. S., Yang, Y., & Ding, L. (2020) · The Journal of Experimental Medicine · doi:10.1084/jem.20200882 · Cited by 61
The Role of Notch and Wnt Signaling in MSC Communication in Normal and Leukemic Bone Marrow Niche
Kamga, P. T., Bazzoni, R., Collo, G. D., Cassaro, A., Tanasi, I., Russignan, A., Tecchio, C., & Krampera, M. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.599276 · Cited by 57
Cellular Senescence and Inflammaging in the Bone: Pathways, Genetics, Anti-Aging Strategies and Interventions
Lawrence, M., Goyal, A., Pathak, S., & Ganguly, P. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25137411 · Cited by 60
Nanotopography – potential relevance in the stem cell niche
Turner, L.-A., & Dalby, M. J. (2014) · Biomaterials Science · doi:10.1039/c4bm00155a · Cited by 53
New agents in HSC mobilization
Domingues, M. J., Nilsson, S. K., & Cao, B. (2016) · International Journal of Hematology · doi:10.1007/s12185-016-2156-2 · Cited by 54
Elements of the niche for adult stem cell expansion
Redondo, P. A., Pavlou, M., Loizidou, M., & Cheema, U. (2017) · Journal of Tissue Engineering · doi:10.1177/2041731417725464 · Cited by 55
Aging- and Senescence-associated Changes of Mesenchymal Stromal Cells in Myelodysplastic Syndromes
Mattiucci, D., Maurizi, G., Leoni, P., & Poloni, A. (2018) · Cell Transplantation · doi:10.1177/0963689717745890 · Cited by 55
Adipocytes in hematopoiesis and acute leukemia: friends, enemies, or innocent bystanders?
Zinngrebe, J., Debatin, K., & Fischer‐Posovszky, P. (2020) · Leukemia · doi:10.1038/s41375-020-0886-x · Cited by 64
Bone marrow adipose tissue: Role in bone remodeling and energy metabolism
Tencerová, M., Ferenčáková, M., & Kassem, M. S. (2021) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2021.101545 · Cited by 55
A PPARγ transcriptional cascade directs adipose progenitor cell-niche interaction and niche expansion
Jiang, Y., Berry, D. C., Jo, A.-Y., Tang, W., Arpke, R. W., Kyba, M., & Graff, J. M. (2017) · Nature Communications · doi:10.1038/ncomms15926 · Cited by 55
Poor graft function after allogeneic hematopoietic stem cell transplantation—an old complication with new insights☆
Kong, Y. (2018) · Seminars in Hematology · doi:10.1053/j.seminhematol.2018.08.004 · Cited by 55
Monocyte and Macrophage Dynamics in the Cardiovascular System
Fayad, Z. A., Świrski, F. K., Calcagno, C., Robbins, C. S., Mulder, W. J. M., & Kovacic, J. C. (2018) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2018.08.2150 · Cited by 53
Chronic viral infections persistently alter marrow stroma and impair hematopoietic stem cell fitness
Isringhausen, S., Mun, Y., Kovtonyuk, L. V., Kräutler, N. J., Suessbier, U., Gomariz, Á., Spaltro, G., Helbling, P. M., Wong, H. C., Nagasawa, T., et al. (2021) · The Journal of Experimental Medicine · doi:10.1084/jem.20192070 · Cited by 48
Blood on the tracks: hematopoietic stem cell-endothelial cell interactions in homing and engraftment
Perlin, J. R., Sporrij, A., & Zon, L. I. (2017) · Journal of Molecular Medicine · doi:10.1007/s00109-017-1559-8 · Cited by 52
Advances, challenges, and opportunities in extracellular RNA biology: insights from the NIH exRNA Strategic Workshop
Li, K. V., Rodosthenous, R. S., Kashanchi, F., Gingeras, T., Gould, S. J., Kuo, L. S., Kurre, P., Lee, H., Leonard, J. N., Liu, H., et al. (2018) · JCI Insight · doi:10.1172/jci.insight.98942 · Cited by 51
The CXCL12gamma chemokine immobilized by heparan sulfate on stromal niche cells controls adhesion and mediates drug resistance in multiple myeloma
Ren, Z., Lantermans, H. C., Kuil, A., Kraan, W., Arenzana‐Seisdedos, F., Kersten, M. J., Spaargaren, M., & Pals, S. T. (2021) · Journal of Hematology & Oncology · doi:10.1186/s13045-021-01031-3 · Cited by 52
The osteoblastic niche in the context of multiple myeloma
Toscani, D., Bolzoni, M., Accardi, F., Aversa, F., & Giuliani, N. (2015) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12578 · Cited by 52
Vascular Platform to Define Hematopoietic Stem Cell Factors and Enhance Regenerative Hematopoiesis
Poulos, M. G., Crowley, M. J. P., Gutkin, M. C., Ramalingam, P., Schachterle, W., Thomas, J., Elemento, O., & Butler, J. M. (2015) · Stem Cell Reports · doi:10.1016/j.stemcr.2015.08.018 · Cited by 52
Adult Stem Cell Responses to Nanostimuli
Tsimbouri, P. M. (2015) · Journal of Functional Biomaterials · doi:10.3390/jfb6030598 · Cited by 57
A T Cell View of the Bone Marrow
Bonomo, A. C., Monteiro, A. C., Gonçalves-Silva, T., Cordeiro-Spinetti, E., Galvani, R. G. A., & Balduíno, A. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00184 · Cited by 54
Environmental and human relevant PFOS and PFOA doses alter human mesenchymal stem cell self-renewal, adipogenesis and osteogenesis
Liu, S., Yang, R., Yin, N., Wang, Y., & Faiola, F. (2018) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2018.11.064 · Cited by 55
A Human Hematopoietic Niche Model Supporting Hematopoietic Stem and Progenitor Cells In Vitro
Braham, M. V. J., Yim, A. S. P. L., Mateos, J. G., Minnema, M. C., Dhert, W. J. A., Öner, F. C., Robin, C., & Alblas, J. (2019) · Advanced Healthcare Materials · doi:10.1002/adhm.201801444 · Cited by 56
Multiple functions of DYRK2 in cancer and tissue development
Yoshida, S., & Yoshida, K. (2019) · FEBS Letters · doi:10.1002/1873-3468.13601 · Cited by 52
Fat for fuel: lipid metabolism in haematopoiesis
Pernes, G., Flynn, M., Lancaster, G. I., & Murphy, A. J. (2019) · Clinical & Translational Immunology · doi:10.1002/cti2.1098 · Cited by 53
Bone marrow Tregs mediate stromal cell function and support hematopoiesis via IL-10
Camacho, V., Matkins, V. R., Patel, S. B., Lever, J. M., Yang, Z., Li, Y., Landuyt, A. E., Dean, E. C., George, J. F., Yang, H. H., et al. (2020) · JCI Insight · doi:10.1172/jci.insight.135681 · Cited by 54
Skeletal Stem/Progenitor Cells in Periosteum and Skeletal Muscle Share a Common Molecular Response to Bone Injury
Julien, A., Perrin, S., Martínez‐Sarrà, E., Kanagalingam, A., Carvalho, C., Luka, M., Ménager, M. M., & Colnot, C. (2020) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.4616 · Cited by 56

Authors: Morrison, S. J., & Scadden, D. T.
Affiliations: Howard Hughes Medical Institute (US)
Harvard University (US)
Corresponding author: Morrison, Sean J.
Scadden, David T.
ORCID: Morrison, Sean J.
Scadden, David T.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2014-01
Volume: 505
Issue: 7483
Pages: 327-334
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature12984
PMC: PMC4514480
OpenAlex: W2149053153
Semantic Scholar: 63cdd906a38c49f8d452a64cb77d5a597cfbfb38
Cited by: 2,451
References: 130
Citations by year: 2026: 139 · 2025: 176 · 2024: 141 · 2023: 177 · 2022: 194 · 2021: 210 · 2020: 226 · 2019: 225 · 2018: 240 · 2017: 223 · 2016: 225 · 2015: 184 · 2014: 89
FWCI: 36.68
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Funders: Howard Hughes Medical Institute
National Heart, Lung, and Blood Institute (HL096372, R01HL044851, R03HL096372, HL044851, HL097760, R01HL097760)
National Institute of Biomedical Imaging and Bioengineering (R01EB014703, EB014703)
Topics: Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
Health Sciences › Medicine › Hematology › Multiple Myeloma Research and Treatments
Keywords: hematopoietic stem cells, bone marrow microenvironment, hematopoiesis, perivascular niche, mesenchymal stem cells, endothelial cells, trabecular bone, endosteum, stem cell niche
MeSH terms: Animals, Bone and Bones, Bone Marrow, Hematopoietic Stem Cells, Humans, Osteoblasts, Endothelial Cells, Stem Cell Niche, Mesenchymal Stem Cells

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The bone marrow niche for haematopoietic stem cells

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks