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Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia
Open accessAbstract
In acute myeloid leukaemia (AML), the cell of origin, nature and biological consequences of initiating lesions, and order of subsequent mutations remain poorly understood, as AML is typically diagnosed without observation of a pre-leukaemic phase. Here, highly purified haematopoietic stem cells (HSCs), progenitor and mature cell fractions from the blood of AML patients were found to contain recurrent DNMT3A mutations (DNMT3A(mut)) at high allele frequency, but without coincident NPM1 mutations (NPM1c) present in AML blasts. DNMT3A(mut)-bearing HSCs showed a multilineage repopulation advantage over non-mutated HSCs in xenografts, establishing their identity as pre-leukaemic HSCs. Pre-leukaemic HSCs were found in remission samples, indicating that they survive chemotherapy. Therefore DNMT3A(mut) arises early in AML evolution, probably in HSCs, leading to a clonally expanded pool of pre-leukaemic HSCs from which AML evolves. Our findings provide a paradigm for the detection and treatment of pre-leukaemic clones before the acquisition of additional genetic lesions engenders greater therapeutic resistance.
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“Recent studies in patients with AML have confirmed the functional importance and clinical significance of preleukemic stem cell populations as the cellular origin of leukemia-initiating cells in human disease27, 48.”
From Minimal PU.1 reduction induces a preleukemic state and promotes development of acute myeloid leukemia (2015) · cites this paper as [48]
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“DNMT3A is also recurrently mutated in blood diseases such as acute myeloid leukemia (AML; ref. 9) and myelodysplastic syndromes (MDS; ref. 10) where it functions as an initiating mutation (11).”
From Txnip Enhances Fitness of Dnmt3a -Mutant Hematopoietic Stem Cells via p21 (2022) · cites this paper as [11]
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“In later studies, DNA sequencing of HSCs from AML patients in remission revealed that stem cells with only a single driver mutation were often present, suggesting that pre-malignant clonal hematopoiesis was a generalizable finding in AML 23–25.”
From Clonal hematopoiesis in human aging and disease (2019) · cites this paper as [24]
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Cites
Genetic Alterations during Colorectal-Tumor Development
Vogelstein, B., Fearon, E. R., Hamilton, S. R., Kern, S. E., Preisinger, A. C., Leppert, M., de Vries-Smits, A. M. M., & Bos, J. L. (1988) · New England Journal of Medicine · doi:10.1056/nejm198809013190901 · Cited by 6,704
Genomic and Epigenomic Landscapes of Adult De Novo Acute Myeloid Leukemia
The Cancer Genome Atlas Research Network (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1301689 · Cited by 5,078
Mutational landscape and significance across 12 major cancer types
Kandoth, C., McLellan, M. D., Vandin, F., Ye, K., Niu, B., Lu, C., Xie, M., Zhang, Q., McMichael, J. F., Wyczalkowski, M. A., et al. (2013) · Nature · doi:10.1038/nature12634 · Cited by 4,419
Greaves, M., & Maley, C. C. (2012) · Nature · doi:10.1038/nature10762 · Cited by 3,162
Distant metastasis occurs late during the genetic evolution of pancreatic cancer
Yachida, S., Jones, S., Bozic, I., Antal, T., Leary, R., Fu, B., Kamiyama, M., Hruban, R. H., Eshleman, J. R., Nowak, M. A., et al. (2010) · Nature · doi:10.1038/nature09515 · Cited by 2,502
Hu, Y., & Smyth, G. K. (2009) · Journal of Immunological Methods · doi:10.1016/j.jim.2009.06.008 · Cited by 2,084
Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing
Ding, L., Ley, T. J., Larson, D. E., Miller, C. A., Koboldt, D. C., Welch, J. S., Ritchey, J. K., Young, M. A., Lamprecht, T., McLellan, M. D., et al. (2012) · Nature · doi:10.1038/nature10738 · Cited by 1,993
Prognostic Relevance of Integrated Genetic Profiling in Acute Myeloid Leukemia
Patel, J. P., Gönen, M., Figueroa, M. E., Fernandez, H. F., Sun, Z., Racevskis, J., Vlierberghe, P. V., Dolgalev, I., Thomas, S., Aminova, O., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1112304 · Cited by 1,990
DNMT3A Mutations in Acute Myeloid Leukemia
Ley, T. J., Ding, L., Walter, M. J., McLellan, M. D., Lamprecht, T., Larson, D. E., Kandoth, C., Payton, J. E., Baty, J., Welch, J., et al. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa1005143 · Cited by 1,983
The patterns and dynamics of genomic instability in metastatic pancreatic cancer
Campbell, P. J., Yachida, S., Mudie, L. J., Stephens, P. J., Pleasance, E. D., Stebbings, L. A., Morsberger, L. A., Latimer, C., McLaren, S., Lin, M.-L., et al. (2010) · Nature · doi:10.1038/nature09460 · Cited by 1,317
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Xu, J., Zhang, W., Yan, X., Lin, X., Li, W., Mi, J., Li, J., Zhu, J., Zhu, C. H., & Chen, S. (2016) · Journal of Hematology & Oncology · doi:10.1186/s13045-016-0337-3 · Cited by 39
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Hartmann, L., & Metzeler, K. H. (2019) · Genes Chromosomes and Cancer · doi:10.1002/gcc.22756 · Cited by 42
Nagy, Á. M., Ősz, Á., Budczies, J., Krizsán, S., Szombath, G., Demeter, J., Bödör, C., & Győrffy, B. (2019) · Journal of Advanced Research · doi:10.1016/j.jare.2019.05.006 · Cited by 39
Niu, X., Rothe, K., Chen, M., Grasedieck, S., Li, R., Nam, S.-E., Zhang, X., Novakovskiy, G., Ahn, Y.-H., Maksakova, I. A., et al. (2021) · Blood · doi:10.1182/blood.2020007651 · Cited by 39
Giacomo, D. D., Starza, R. L., Gorello, P., Pellanera, F., Atak, Z. K., Keersmaecker, K. D., Pierini, V., Harrison, C. J., Arniani, S., Moretti, M., et al. (2021) · Blood · doi:10.1182/blood.2020010510 · Cited by 39
Multistep tumorigenesis in peripheral T cell lymphoma
Sakata‐Yanagimoto, M. (2015) · International Journal of Hematology · doi:10.1007/s12185-015-1738-8 · Cited by 38
Wei, A. H., Tan, P. T., Perruzza, S., Govindaraj, C., Fleming, S. A., McManus, J. F., Avery, S., Patil, S. S., Stevenson, W. S., Plebanski, M., et al. (2015) · British Journal of Haematology · doi:10.1111/bjh.13281 · Cited by 38
Benoit, Y. D., Guezguez, B., Boyd, A. L., & Bhatia, M. (2014) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-13-2491 · Cited by 40
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Celik, H., Kramer, A. C., & Challen, G. A. (2016) · International Journal of Hematology · doi:10.1007/s12185-016-1957-7 · Cited by 39
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Werstein, B., Dunlap, J. B., Cascio, M. J., Ohgami, R. S., Fan, G., Press, R. D., & Raess, P. W. (2019) · Journal of Molecular Diagnostics · doi:10.1016/j.jmoldx.2019.11.004 · Cited by 38
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Lewis, A. C., & Kats, L. M. (2021) · EMBO Molecular Medicine · doi:10.15252/emmm.202012670 · Cited by 36
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Veschi, V., Turdo, A., Modica, C., Verona, F., Franco, S. D., Gaggianesi, M., Tirrò, E., Bella, S. D., Iacono, M. L., Pantina, V. D., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-36922-1 · Cited by 37
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Carroll, D. W., & Clair, D. K. S. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7326 · Cited by 36
Alteraciones moleculares en leucemia mieloide aguda y sus implicaciones clínicas y terapéuticas
Infante, M. S., Piris, M. A., & Hernández‐Rivas, J. (2018) · Medicina Clínica · doi:10.1016/j.medcli.2018.05.002 · Cited by 39
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Gu, R., Yang, X. W., & Wei, H. (2018) · Biomarker Research · doi:10.1186/s40364-018-0146-7 · Cited by 37
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Castelli, G., Pelosi, E., & Testa, U. (2019) · Cancers · doi:10.3390/cancers11020260 · Cited by 39
Kim, R., Bergugnat, H., Larcher, L., Duchmann, M., Passet, M., Gachet, S., Cuccuini, W., Lafage‐Pochitaloff, M., Pastoret, C., Grardel, N., et al. (2023) · Blood Cancer Discovery · doi:10.1158/2643-3230.bcd-22-0154 · Cited by 39
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Knapp, D. J. H. F., Hammond, C. A., Miller, P. H., Rabu, G. M., Beer, P. A., Řičicová, M., Lecault, V., Costa, D. D., VanInsberghe, M. A., Cheung, A. M. S., et al. (2017) · Stem Cell Reports · doi:10.1016/j.stemcr.2016.12.003 · Cited by 42
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Monné, M., Marobbio, C. M. T., Agrimi, G., Palmieri, L., & Palmieri, F. (2022) · IUBMB Life · doi:10.1002/iub.2658 · Cited by 34
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Falini, B., Sportoletti, P., Brunetti, L., & Martelli, M. P. (2015) · British Journal of Haematology · doi:10.1111/bjh.13409 · Cited by 38
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Medinger, M., Lengerke, C., & Passweg, J. R. (2016) · Europe PMC (PubMed Central) · Cited by 36
Biechonski, S., Olender, L., Zipin‐Roitman, A., Yassin, M., Aqaqe, N., Marcu‐Malina, V., Rall-Scharpf, M., Trottier, M., Meyn, M. S., Wiesmüller, L., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-24440-w · Cited by 36
Bewersdorf, J. P., Ardasheva, A., Podoltsev, N. A., Singh, A., Biancon, G., Halene, S., & Zeidan, A. M. (2019) · Blood Reviews · doi:10.1016/j.blre.2019.100587 · Cited by 37
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Lee, M. K. S., Dragoljevic, D., Veiga, C. B., Wang, N., Yvan‐Charvet, L., & Murphy, A. J. (2020) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2020.02.005 · Cited by 37
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Self-citationTremblay, C. S., Chiu, S. K., Saw, J., McCalmont, H., Litalien, V., Boyle, J. A., Sonderegger, S., Chau, N., Evans, K., Cerruti, L., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-20091-6 · Cited by 37
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Congrains, A., Bianco, J., Rosa, R. G., Mancuso, R. I., & Saad, S. T. O. (2021) · Materials · doi:10.3390/ma14030569 · Cited by 40
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Kikushige, Y. (2021) · Cancer Science · doi:10.1111/cas.15042 · Cited by 36
Kawashima, N., Ishikawa, Y., Kim, J. H., Ushijima, Y., Akashi, A., Yamaguchi, Y., Hattori, H., Nakashima, M., Ikeno, S., Kihara, R., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-29304-6 · Cited by 38
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Natarajan, P. (2022) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.122.318181 · Cited by 35
Xue, L., Pulikkan, J. A., Valk, P. J. M., & Castilla, L. H. (2014) · Blood · doi:10.1182/blood-2013-12-541730 · Cited by 35
van Neerven, S. M., Tieken, M., Vermeulen, L., & Bijlsma, M. F. (2015) · Molecular & Cellular Oncology · doi:10.1080/23723556.2015.1098791 · Cited by 37
Harada, H., & Harada, Y. (2015) · Cancer Science · doi:10.1111/cas.12614 · Cited by 37
Beer, P. A., Knapp, D. J. H. F., Miller, P. H., Kannan, N., Sloma, I., Heel, K., Babovic, S., Bulaeva, E., Rabu, G. M., Terry, J., et al. (2014) · Blood · doi:10.1182/blood-2014-06-581173 · Cited by 34
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Goswami, M., McGowan, K. S., Lu, K. Y., Jain, N. A., Candia, J., Hensel, N. F., Tang, J., Calvo, K. R., Battiwalla, M., Barrett, A. J., et al. (2015) · Bone Marrow Transplantation · doi:10.1038/bmt.2014.326 · Cited by 34
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Dulphy, N., Chrétien, A.-S., Khaznadar, Z., Fauriat, C., Nanbakhsh, A., Caignard, A., Chouaı̈b, S., Olive, D., & Toubert, A. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00094 · Cited by 39
Li, X.-Y., Yang, X. F., Zhao, Q.-D., Han, Z.-P., Liang, L., Pan, X.-R., Zhu, J.-N., Li, R., Wu, M., & Wei, L. (2016) · Cancer Letters · doi:10.1016/j.canlet.2016.10.044 · Cited by 34
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Konieczny, J., & Arranz, L. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19092567 · Cited by 34
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Jamrog, L. A., Chemin, G., Fregona, V., Coster, L., Pasquet, M., Oudinet, C., Rouquié, N., Prade, N., Lagarde, S., Cresson, C., et al. (2018) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.1721678115 · Cited by 29
Chen, L., Fan, X., Zhu, J., Chen, X., Liu, Y., & Zhou, H. (2020) · RNA Biology · doi:10.1080/15476286.2020.1726637 · Cited by 34
MDMX acts as a pervasive preleukemic-to-acute myeloid leukemia transition mechanism
Ueda, K., Kumari, R., Schwenger, E., Wheat, J. C., Bohorquez, O., Narayanagari, S.-R., Taylor, S. J., Carvajal, L. A., Pradhan, K., Bartholdy, B., et al. (2021) · Cancer Cell · doi:10.1016/j.ccell.2021.02.006 · Cited by 34
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Feldman, T., Bercovich, A., Moskovitz, Y., Chapal-Ilani, N., Mitchell, A., Medeiros, J. J. F., Biezuner, T., Kaushansky, N., Minden, M. D., Gupta, V. K., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-22803-y · Cited by 34
Self-citationMitchell, K., & Steidl, U. G. (2019) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a036251 · Cited by 37
Schwede, M., Jahn, K., Kuipers, J., Miles, L. A., Bowman, R. L., Robinson, T. M., Furudate, K., Uryu, H., Tanaka, T. N., Sasaki, Y., et al. (2024) · Leukemia · doi:10.1038/s41375-024-02211-z · Cited by 34
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Hahn, C. N., Ross, D. M., Feng, J., Beligaswatte, A. M., Hiwase, D., Parker, W. T., Ho, M., Zawitkowski, M., Ambler, K., Cheetham, G., et al. (2015) · Leukemia · doi:10.1038/leu.2015.67 · Cited by 33
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Thoms, J. A. I., Beck, D., & Pimanda, J. E. (2019) · Genes Chromosomes and Cancer · doi:10.1002/gcc.22794 · Cited by 33
Silzle, T., Blum, S., Schuler, E., Kaivers, J., Rudelius, M., Hildebrandt, B., Gattermann, N., Haas, R. R., & Germing, U. (2019) · Blood Cancer Journal · doi:10.1038/s41408-019-0223-7 · Cited by 33
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Ishii, H., & Yano, S. (2022) · Cancers · doi:10.3390/cancers14112806 · Cited by 33
Wu, D., Luo, X., Feurstein, S. K., Kesserwan, C. A., Mohan, S., Álvarez, D. E. P., & Godley, L. A. (2020) · Haematologica · doi:10.3324/haematol.2018.214221 · Cited by 33
Aging, clonal hematopoiesis and preleukemia: not just bad luck?
Shlush, L. I., Zandi, S., Itzkovitz, S., & Schuh, A. C. (2015) · International Journal of Hematology · doi:10.1007/s12185-015-1870-5 · Cited by 36
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Furness, C. L., Mansur, M. B., Weston, V., Ermini, L., van Delft, F. W., Jenkinson, S., Gale, R. E., Harrison, C. J., Pombo‐de‐Oliveira, M. S., Sánchez-Martín, M., et al. (2018) · Leukemia · doi:10.1038/s41375-018-0046-8 · Cited by 32
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Chen, S., Gao, R., Yao, C., Kobayashi, M., Liu, S. Z., Yöder, M. C., Broxmeyer, H. E., Kapur, R., Boswell, H. S., Mayo, L. D., et al. (2017) · Leukemia · doi:10.1038/leu.2017.325 · Cited by 33
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Ly, M., Rentas, S., Vujovic, A., Wong, N., Moreira, S., Xu, J., Holzapfel, N. T., Bhatia, S., Tran, D., Minden, M. D., et al. (2019) · Cancer Research · doi:10.1158/0008-5472.can-19-0274 · Cited by 34
Self-citationHassan, N., Yi, H., Malik, B., Gaspard-Boulinc, L., Samaraweera, S. E., Casolari, D. A., Seneviratne, J. A., Balachandran, A., Chew, T., Duly, A. M. P., et al. (2024) · Blood · doi:10.1182/blood.2024024072 · Cited by 30
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Ford, A. M., Mansur, M. B., Furness, C. L., van Delft, F. W., Okamura, J., Suzuki, T., Kobayashi, H., Kaneko, Y., & Greaves, M. F. (2015) · Leukemia · doi:10.1038/leu.2015.132 · Cited by 32
Malmberg, E. D., Ståhlman, S., Rehammar, A., Samuelsson, T., Alm, S. J., Kristiansson, E., Abrahamsson, J., Garelius, H. G., Pettersson, L., Ehinger, M., et al. (2016) · European Journal Of Haematology · doi:10.1111/ejh.12780 · Cited by 31
Sasaki, T., Rivera‐Mulia, J. C., Vera, D. L., Zimmerman, J., Das, S., Padget, M. R., Nakamichi, N., Chang, B. H., Tyner, J. W., Druker, B. J., et al. (2017) · Experimental Hematology · doi:10.1016/j.exphem.2017.04.004 · Cited by 30
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Kuo, F. C., & Dong, F. (2015) · Current Hematologic Malignancy Reports · doi:10.1007/s11899-015-0256-3 · Cited by 30
Nybakken, G. E., Canaani, J., Roy, D., Morrissette, J. D., Watt, C. D., Shah, N. P., Smith, C. C., Bagg, A., Carroll, M. P., & Perl, A. E. (2015) · Leukemia · doi:10.1038/leu.2015.320 · Cited by 31
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Roloff, G. W., Lai, C., Hourigan, C. S., & Dillon, L. W. (2017) · Journal of Clinical Medicine · doi:10.3390/jcm6090087 · Cited by 32
Teixeira, A., Carreira, L., Abalde‐Cela, S., Sampaio‐Marques, B., Areias, A. C., Ludovico, P., & Diéguez, L. (2023) · Cancers · doi:10.3390/cancers15051362 · Cited by 37
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Damm, F., Markus, B., Thol, F. R., Morgan, M. A., Göhring, G., Schlegelberger, B., Krauter, J., Heuser, M., Bernard, O., & Ganser, A. (2014) · Genes Chromosomes and Cancer · doi:10.1002/gcc.22191 · Cited by 28
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Al‐Mawali, A., Pinto, A. D., & Al‐Zadjali, S. (2017) · Acta Haematologica · doi:10.1159/000480448 · Cited by 29
Paietta, E. M. (2018) · Blood · doi:10.1182/blood-2018-01-828145 · Cited by 29
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Metadata
- Authors
- Shlush, L. I., Zandi, S., Mitchell, A., Chen, W. C., Brandwein, J. M., Gupta, V., Kennedy, J. A., Schimmer, A. D., Schuh, A. C., Yee, K. W., McLeod, J. L., Doedens, M., Medeiros, J. J. F., Marke, R., Kim, H. J., Lee, K., McPherson, J. D., Hudson, T. J., Pan-Leukemia Gene Panel Consortium, T. H., Brown, A. M. K., Yousif, F., Trinh, Q. M., Stein, L. D., Minden, M. D., Wang, J. C. Y., & Dick, J. E.
- Affiliations
- University Health Network (CA)
- Chonnam National University (KR)
- Ontario Institute for Cancer Research (CA)
- Corresponding author
- Dick, John E.
- ORCID
- Venue
- Nature
- Published
- 2014-02-12
- Volume
- 506
- Issue
- 7488
- Pages
- 328-333
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC4991939
- OpenAlex
- W2076031927
- Cited by
- 1,443
- References
- 53
- Citations by year
- 2026: 50 · 2025: 48 · 2024: 75 · 2023: 95 · 2022: 94 · 2021: 110 · 2020: 136 · 2019: 131 · 2018: 139 · 2017: 160 · 2016: 153 · 2015: 159 · 2014: 88
- FWCI
- 132.63
- Type
- journal article
- Language
- en
- Update notices
- correction (2014-04-16)
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- Funders
- Hospital for Sick Children
- Canadian Institutes of Health Research (105367_1)
- National Cancer Institute (R21CA152613)
- Topics
- Health Sciences › Medicine › Hematology › Acute Myeloid Leukemia Research
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinoids in leukemia and cellular processes
- Keywords
- acute myeloid leukemia, DNMT3A mutation, NPM1 mutation, clonal evolution, treatment resistance, relapse, clonal expansion, chemotherapy remission, tumor heterogeneity, xenografts, mutation order, hematopoiesis
- MeSH terms
- DNA Methyltransferase 3A, Nucleophosmin, Animals, Cell Differentiation, Cell Division, Clone Cells, DNA (Cytosine-5-)-Methyltransferases, Female, Hematopoiesis, Hematopoietic Stem Cells, Humans, Isocitrate Dehydrogenase, Mutation, Neoplasm Transplantation, Nuclear Proteins, Remission Induction, T-Lymphocytes, Neoplastic Stem Cells, Leukemia, Myeloid, Acute, Mice, SCID, Mice, Inbred NOD, Drug Resistance, Neoplasm, Cell Lineage, Mice, Heterografts
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