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Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia
Open accessAbstract
In acute myeloid leukaemia (AML), the cell of origin, nature and biological consequences of initiating lesions, and order of subsequent mutations remain poorly understood, as AML is typically diagnosed without observation of a pre-leukaemic phase. Here, highly purified haematopoietic stem cells (HSCs), progenitor and mature cell fractions from the blood of AML patients were found to contain recurrent DNMT3A mutations (DNMT3A(mut)) at high allele frequency, but without coincident NPM1 mutations (NPM1c) present in AML blasts. DNMT3A(mut)-bearing HSCs showed a multilineage repopulation advantage over non-mutated HSCs in xenografts, establishing their identity as pre-leukaemic HSCs. Pre-leukaemic HSCs were found in remission samples, indicating that they survive chemotherapy. Therefore DNMT3A(mut) arises early in AML evolution, probably in HSCs, leading to a clonally expanded pool of pre-leukaemic HSCs from which AML evolves. Our findings provide a paradigm for the detection and treatment of pre-leukaemic clones before the acquisition of additional genetic lesions engenders greater therapeutic resistance.
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“Recent studies in patients with AML have confirmed the functional importance and clinical significance of preleukemic stem cell populations as the cellular origin of leukemia-initiating cells in human disease27, 48.”
From Minimal PU.1 reduction induces a preleukemic state and promotes development of acute myeloid leukemia (2015) · cites this paper as [48]
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“DNMT3A is also recurrently mutated in blood diseases such as acute myeloid leukemia (AML; ref. 9) and myelodysplastic syndromes (MDS; ref. 10) where it functions as an initiating mutation (11).”
From Txnip Enhances Fitness of Dnmt3a -Mutant Hematopoietic Stem Cells via p21 (2022) · cites this paper as [11]
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“In later studies, DNA sequencing of HSCs from AML patients in remission revealed that stem cells with only a single driver mutation were often present, suggesting that pre-malignant clonal hematopoiesis was a generalizable finding in AML 23–25.”
From Clonal hematopoiesis in human aging and disease (2019) · cites this paper as [24]
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Genetic Alterations during Colorectal-Tumor Development
Vogelstein, B., Fearon, E. R., Hamilton, S. R., Kern, S. E., Preisinger, A. C., Leppert, M., de Vries-Smits, A. M. M., & Bos, J. L. (1988) · New England Journal of Medicine · doi:10.1056/nejm198809013190901 · Cited by 6,704
Genomic and Epigenomic Landscapes of Adult De Novo Acute Myeloid Leukemia
The Cancer Genome Atlas Research Network (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1301689 · Cited by 5,078
Mutational landscape and significance across 12 major cancer types
Kandoth, C., McLellan, M. D., Vandin, F., Ye, K., Niu, B., Lu, C., Xie, M., Zhang, Q., McMichael, J. F., Wyczalkowski, M. A., et al. (2013) · Nature · doi:10.1038/nature12634 · Cited by 4,419
Greaves, M., & Maley, C. C. (2012) · Nature · doi:10.1038/nature10762 · Cited by 3,162
Distant metastasis occurs late during the genetic evolution of pancreatic cancer
Yachida, S., Jones, S., Bozic, I., Antal, T., Leary, R., Fu, B., Kamiyama, M., Hruban, R. H., Eshleman, J. R., Nowak, M. A., et al. (2010) · Nature · doi:10.1038/nature09515 · Cited by 2,502
Hu, Y., & Smyth, G. K. (2009) · Journal of Immunological Methods · doi:10.1016/j.jim.2009.06.008 · Cited by 2,084
Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing
Ding, L., Ley, T. J., Larson, D. E., Miller, C. A., Koboldt, D. C., Welch, J. S., Ritchey, J. K., Young, M. A., Lamprecht, T., McLellan, M. D., et al. (2012) · Nature · doi:10.1038/nature10738 · Cited by 1,993
Prognostic Relevance of Integrated Genetic Profiling in Acute Myeloid Leukemia
Patel, J. P., Gönen, M., Figueroa, M. E., Fernandez, H. F., Sun, Z., Racevskis, J., Vlierberghe, P. V., Dolgalev, I., Thomas, S., Aminova, O., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1112304 · Cited by 1,990
DNMT3A Mutations in Acute Myeloid Leukemia
Ley, T. J., Ding, L., Walter, M. J., McLellan, M. D., Lamprecht, T., Larson, D. E., Kandoth, C., Payton, J. E., Baty, J., Welch, J., et al. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa1005143 · Cited by 1,983
The patterns and dynamics of genomic instability in metastatic pancreatic cancer
Campbell, P. J., Yachida, S., Mudie, L. J., Stephens, P. J., Pleasance, E. D., Stebbings, L. A., Morsberger, L. A., Latimer, C., McLaren, S., Lin, M.-L., et al. (2010) · Nature · doi:10.1038/nature09460 · Cited by 1,317
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Benetatos, L., & Vartholomatos, G. (2016) · Annals of Hematology · doi:10.1007/s00277-016-2636-8 · Cited by 29
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Sandén, C., Lilljebjörn, H., Orsmark‐Pietras, C., Henningsson, R., Saba, K. H., Landberg, N., Thorsson, H., von Palffy, S., Peña‐Martínez, P., Högberg, C., et al. (2020) · Nature Communications · doi:10.1038/s41467-019-14106-0 · Cited by 30
Desai, R. H., Zandvakili, N., & Bohlander, S. K. (2022) · Cancers · doi:10.3390/cancers14092182 · Cited by 37
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Winter, D. R., Jung, S., & Amit, I. (2015) · Nature reviews. Immunology · doi:10.1038/nri3884 · Cited by 30
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Kikushige, Y., & Miyamoto, T. (2014) · International Journal of Hematology · doi:10.1007/s12185-014-1651-6 · Cited by 29
Regain control of p53: Targeting leukemia stem cells by isoform-specific HDAC inhibition
Kuo, Y., Qi, J., & Cook, G. (2016) · Experimental Hematology · doi:10.1016/j.exphem.2016.02.007 · Cited by 31
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Zeng, Z., Konopleva, M. Y., & Andreeff, M. (2017) · Methods in molecular biology · doi:10.1007/978-1-4939-7142-8_5 · Cited by 28
Imi, T., Katagiri, T., Hosomichi, K., Zaimoku, Y., Việt, N. H., Nakagawa, N., Tajima, A., Yoshizato, T., Ogawa, S., & Nakao, S. (2018) · Blood Advances · doi:10.1182/bloodadvances.2017013953 · Cited by 30
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Malcovati, L., & Cazzola, M. (2016) · British Journal of Haematology · doi:10.1111/bjh.14215 · Cited by 29
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Kosan, C., Heidel, F. H., Godmann, M., & Bierhoff, H. (2018) · Cells · doi:10.3390/cells7120237 · Cited by 29
Cao, X., Cai, H., Mao, Y., Wu, Q., Zhang, L., Zhou, D., & Li, J. (2018) · Cancer Cell International · doi:10.1186/s12935-018-0716-7 · Cited by 27
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Jiang, P., Wang, H., Zheng, J., Han, Y., Huang, H., & Qian, P. (2019) · Blood Science · doi:10.1097/bs9.0000000000000018 · Cited by 29
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Goyama, S., Shrestha, M., Schibler, J., Rosenfeldt, L., Miller, W., O'Brien, E., Mizukawa, B., Kitamura, T., Palumbo, J., & Mulloy, J. (2016) · Oncogene · doi:10.1038/onc.2016.416 · Cited by 23
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Basilico, S., & Göttgens, B. (2017) · Journal of Molecular Medicine · doi:10.1007/s00109-017-1535-3 · Cited by 30
Ganguly, B. B., Banerjee, D., & Agarwal, M. B. (2017) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2017.10.001 · Cited by 26
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Han, G., Cui, M., Lu, P., Zhang, T., Yin, R., Hu, J., Chai, J., Wang, J., Gao, K., Liu, W., et al. (2024) · Cell stem cell · doi:10.1016/j.stem.2024.09.008 · Cited by 28
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Yang, L., Liu, Y., Zhang, N., Ding, X., Zhang, W., Shen, K., Huang, L., Zhou, J., Cui, S., Zhu, Z., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.16449 · Cited by 28
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Allegra, A., Caserta, S., Mirabile, G., & Gangemi, S. (2023) · Cells · doi:10.3390/cells12192392 · Cited by 30
Herbrich, S. M., Anandhan, S., Andrewes, S. W., Chaib, M., Nagarajan, A., Guan, B., Tang, D. N., Gandhi, N., Gilliam, J., Radovich, M., et al. (2025) · Cancer Cell · doi:10.1016/j.ccell.2025.09.011 · Cited by 31
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Perner, F., & Armstrong, S. A. (2020) · Cells · doi:10.3390/cells9122721 · Cited by 25
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Cai, Q., Jeannet, R., Hua, W.-K., Cook, G., Zhang, B., Qi, J., Liu, H., Li, L., Chen, C., Marcucci, G., et al. (2016) · Blood · doi:10.1182/blood-2016-01-693119 · Cited by 25
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Zeng, A. G. X., Nagree, M. S., Jakobsen, N. A., Shah, S., Murison, A., Cheong, J.-G., Turkalj, S., Lim, I., Jin, L.-Q., Araújo, J., et al. (2023) · bioRxiv · doi:10.1101/2023.09.11.557271 · Cited by 15
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Datar, G. K., Khabusheva, E., Anand, A., Beale, J., Sadek, M., Chen, C.-W. D., Potolitsyna, E., de Alcântara-Contessoto, N. S., Liu, G., Fuente, J. D. L., et al. (2025) · Cell · doi:10.1016/j.cell.2025.10.010 · Cited by 28
Kim, T., Yoshida, K., Kim, Y. K., Tyndel, M. S., Park, H. J., Choi, S., Ahn, J., Jung, S.-H., Yang, D.-H., Lee, J.-J., et al. (2015) · Leukemia · doi:10.1038/leu.2015.264 · Cited by 24
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Wingert, S., & Rieger, M. A. (2016) · Experimental Hematology · doi:10.1016/j.exphem.2016.04.006 · Cited by 25
Bera, R., Chiu, M.-C., Huang, Y., Liang, D., Lee, Y., & Shih, L. (2018) · Neoplasia · doi:10.1016/j.neo.2018.08.013 · Cited by 27
IL1RL1 is dynamically expressed on Cbfb-MYH11+ leukemia stem cells and promotes cell survival
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Balagopal, V., Hantel, A., Kadri, S., Steinhardt, G., Zhen, C. J., Kang, W., Wanjari, P., Ritterhouse, L. L., Stock, W., & Segal, J. P. (2019) · PLoS ONE · doi:10.1371/journal.pone.0224097 · Cited by 24
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Chu, X., Zhong, L., Dan, W., Wang, X., Zhang, Z., Liu, Z., Lu, Y., Shao, X., Zhou, Z., Chen, S., et al. (2022) · Cell Communication and Signaling · doi:10.1186/s12964-022-00978-1 · Cited by 24
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Tremblay, C. S., & Curtis, D. J. (2014) · Current Opinion in Hematology · doi:10.1097/moh.0000000000000058 · Cited by 24
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Post-transcriptional regulation in hematopoiesis: RNA binding proteins take control
de Rooij, L. P. M. H., Chan, D. C. H., Chahi, A. K., & Hope, K. J. (2018) · Biochemistry and Cell Biology · doi:10.1139/bcb-2017-0310 · Cited by 23
Aivalioti, M. M., Bartholdy, B. A., Pradhan, K., Bhagat, T. D., Zintiridou, A., Jeong, J. J., Thiruthuvanathan, V. J., Pujato, M., Paranjpe, A., Zhang, C., et al. (2022) · Blood Cancer Discovery · doi:10.1158/2643-3230.bcd-21-0226 · Cited by 22
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Nowak, D., Liem, N. L. M., Mossner, M., Klaumuenzer, M., Papa, R. A., Nowak, V., Jann, J. C., Akagi, T., Kawamata, N., Okamoto, R., et al. (2014) · Experimental Hematology · doi:10.1016/j.exphem.2014.09.007 · Cited by 22
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Benard, B. A., Gentles, A. J., Köhnke, T., Majeti, R., & Thomas, D. (2019) · Leukemia · doi:10.1038/s41375-019-0387-y · Cited by 23
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Lemonnier, F., & Mak, T. W. (2017) · The Journal of Pathology · doi:10.1002/path.4920 · Cited by 22
Mirzaei, A., Mohammadi, S., Ghaffari, S. H., Nikbakht, M., Bashash, D., Alimoghaddam, K., & Ghavamzadeh, A. (2017) · Europe PMC (PubMed Central) · doi:10.22034/apjcp.2017.18.6.1707 · Cited by 22
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Self-citationGhia, E. M., Rassenti, L. Z., Neuberg, D. S., Blanco, A., Yousif, F., Smith, E. N., McPherson, J. D., Hudson, T. J., Harismendy, O., Frazer, K. A., et al. (2019) · Blood · doi:10.1182/blood-2018-09-873695 · Cited by 22
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Metadata
- Authors
- Shlush, L. I., Zandi, S., Mitchell, A., Chen, W. C., Brandwein, J. M., Gupta, V., Kennedy, J. A., Schimmer, A. D., Schuh, A. C., Yee, K. W., McLeod, J. L., Doedens, M., Medeiros, J. J. F., Marke, R., Kim, H. J., Lee, K., McPherson, J. D., Hudson, T. J., Pan-Leukemia Gene Panel Consortium, T. H., Brown, A. M. K., Yousif, F., Trinh, Q. M., Stein, L. D., Minden, M. D., Wang, J. C. Y., & Dick, J. E.
- Affiliations
- University Health Network (CA)
- Chonnam National University (KR)
- Ontario Institute for Cancer Research (CA)
- Corresponding author
- Dick, John E.
- ORCID
- Venue
- Nature
- Published
- 2014-02-12
- Volume
- 506
- Issue
- 7488
- Pages
- 328-333
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC4991939
- OpenAlex
- W2076031927
- Cited by
- 1,443
- References
- 53
- Citations by year
- 2026: 50 · 2025: 48 · 2024: 75 · 2023: 95 · 2022: 94 · 2021: 110 · 2020: 136 · 2019: 131 · 2018: 139 · 2017: 160 · 2016: 153 · 2015: 159 · 2014: 88
- FWCI
- 132.63
- Type
- journal article
- Language
- en
- Update notices
- correction (2014-04-16)
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- Funders
- Hospital for Sick Children
- Canadian Institutes of Health Research (105367_1)
- National Cancer Institute (R21CA152613)
- Topics
- Health Sciences › Medicine › Hematology › Acute Myeloid Leukemia Research
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinoids in leukemia and cellular processes
- Keywords
- acute myeloid leukemia, DNMT3A mutation, NPM1 mutation, clonal evolution, treatment resistance, relapse, clonal expansion, chemotherapy remission, tumor heterogeneity, xenografts, mutation order, hematopoiesis
- MeSH terms
- DNA Methyltransferase 3A, Nucleophosmin, Animals, Cell Differentiation, Cell Division, Clone Cells, DNA (Cytosine-5-)-Methyltransferases, Female, Hematopoiesis, Hematopoietic Stem Cells, Humans, Isocitrate Dehydrogenase, Mutation, Neoplasm Transplantation, Nuclear Proteins, Remission Induction, T-Lymphocytes, Neoplastic Stem Cells, Leukemia, Myeloid, Acute, Mice, SCID, Mice, Inbred NOD, Drug Resistance, Neoplasm, Cell Lineage, Mice, Heterografts
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