Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia

Genetic Alterations during Colorectal-Tumor Development

Vogelstein, B., Fearon, E. R., Hamilton, S. R., Kern, S. E., Preisinger, A. C., Leppert, M., de Vries-Smits, A. M. M., & Bos, J. L. (1988) · New England Journal of Medicine · doi:10.1056/nejm198809013190901 · Cited by 6,704

Genomic and Epigenomic Landscapes of Adult De Novo Acute Myeloid Leukemia

The Cancer Genome Atlas Research Network (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1301689 · Cited by 5,078

Mutational landscape and significance across 12 major cancer types

Kandoth, C., McLellan, M. D., Vandin, F., Ye, K., Niu, B., Lu, C., Xie, M., Zhang, Q., McMichael, J. F., Wyczalkowski, M. A., et al. (2013) · Nature · doi:10.1038/nature12634 · Cited by 4,419

Clonal evolution in cancer

Greaves, M., & Maley, C. C. (2012) · Nature · doi:10.1038/nature10762 · Cited by 3,162

Distant metastasis occurs late during the genetic evolution of pancreatic cancer

Yachida, S., Jones, S., Bozic, I., Antal, T., Leary, R., Fu, B., Kamiyama, M., Hruban, R. H., Eshleman, J. R., Nowak, M. A., et al. (2010) · Nature · doi:10.1038/nature09515 · Cited by 2,502

ELDA: Extreme limiting dilution analysis for comparing depleted and enriched populations in stem cell and other assays

Hu, Y., & Smyth, G. K. (2009) · Journal of Immunological Methods · doi:10.1016/j.jim.2009.06.008 · Cited by 2,084

Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing

Ding, L., Ley, T. J., Larson, D. E., Miller, C. A., Koboldt, D. C., Welch, J. S., Ritchey, J. K., Young, M. A., Lamprecht, T., McLellan, M. D., et al. (2012) · Nature · doi:10.1038/nature10738 · Cited by 1,993

Prognostic Relevance of Integrated Genetic Profiling in Acute Myeloid Leukemia

Patel, J. P., Gönen, M., Figueroa, M. E., Fernandez, H. F., Sun, Z., Racevskis, J., Vlierberghe, P. V., Dolgalev, I., Thomas, S., Aminova, O., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1112304 · Cited by 1,990

DNMT3A Mutations in Acute Myeloid Leukemia

Ley, T. J., Ding, L., Walter, M. J., McLellan, M. D., Lamprecht, T., Larson, D. E., Kandoth, C., Payton, J. E., Baty, J., Welch, J., et al. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa1005143 · Cited by 1,983

The patterns and dynamics of genomic instability in metastatic pancreatic cancer

Campbell, P. J., Yachida, S., Mudie, L. J., Stephens, P. J., Pleasance, E. D., Stebbings, L. A., Morsberger, L. A., Latimer, C., McLaren, S., Lin, M.-L., et al. (2010) · Nature · doi:10.1038/nature09460 · Cited by 1,317

DNMT3A Mutation-Induced CDK1 Overexpression Promotes Leukemogenesis by Modulating the Interaction between EZH2 and DNMT3A

Yang, Y., Dai, Y., Yang, X., Wu, S., & Wang, Y. (2021) · Biomolecules · doi:10.3390/biom11060781 · Cited by 21

Comparison of high‐resolution melting analysis with direct sequencing for the detection of recurrent mutations in DNA methyltransferase 3 A and isocitrate dehydrogenase 1 and 2 genes in acute myeloid leukemia patients

Górniak, P., Ejduk, A., Borg, K., Makuch‐Łasica, H., Nowak, G., Lech‐Marańda, E., Prochorec‐Sobieszek, M., Warzocha, K., & Juszczyński, P. (2015) · European Journal Of Haematology · doi:10.1111/ejh.12566 · Cited by 22

Commentary: The multistage model of carcinogenesis, Peto's paradox and evolution

Nunney, L. (2015) · International Journal of Epidemiology · doi:10.1093/ije/dyv201 · Cited by 21

Efficient combinatorial adaptor-mediated targeting of acute myeloid leukemia with CAR T-cells

Volta, L. G., Myburgh, R., Pellegrino, C. E., Koch, C., Maurer, M., Manfredi, F., Hofstetter, M., Kaiser, A., Schneiter, F., Müller, J., et al. (2024) · Leukemia · doi:10.1038/s41375-024-02409-1 · Cited by 20

Human DNA (cytosine-5)-methyltransferases: a functional and structural perspective for epigenetic cancer therapy

Rondelet, G., & Wouters, J. (2017) · Biochimie · doi:10.1016/j.biochi.2017.06.003 · Cited by 21

Off to a Bad Start: Cancer Initiation by Pluripotency Regulator PRDM14

Tracey, L. J., & Justice, M. J. (2019) · Trends in Genetics · doi:10.1016/j.tig.2019.04.004 · Cited by 21

Effect of DNMT3A variant allele frequency and double mutation on clinicopathologic features of patients with de novo AML

Narayanan, D., Pozdnyakova, O., Hasserjian, R. P., Patel, S. S., & Weinberg, O. K. (2021) · Blood Advances · doi:10.1182/bloodadvances.2021004250 · Cited by 20

Comprehensive analysis of genetic factors predicting overall survival in Myelodysplastic syndromes

Maurya, N., Mohanty, P., Dhangar, S., Panchal, P., Jijina, F. F., Mathan, S. L. P., Shanmukhaiah, C., Madkaikar, M. R., & Vundinti, B. R. (2022) · Scientific Reports · doi:10.1038/s41598-022-09864-9 · Cited by 22

Loss of Dnmt3a increases self-renewal and resistance to pegIFN-α in JAK2 -V617F–positive myeloproliferative neoplasms

Usart, M., Stetka, J., Paz, D. L., Hansen, N., Kimmerlin, Q., Fonseca, T. A., Lock, M., Kubovčáková, L., Karjalainen, R., Hao-Shen, H., et al. (2024) · Blood · doi:10.1182/blood.2023020270 · Cited by 22

The genome-wide molecular signature of transcription factors in leukemia

Prange, K. H. M., Singh, A. A., & Martens, J. H. A. (2014) · Experimental Hematology · doi:10.1016/j.exphem.2014.04.012 · Cited by 19

Ultimate Precision: Targeting Cancer but Not Normal Self-replication

Velcheti, V., Schrump, D. S., & Saunthararajah, Y. (2018) · American Society of Clinical Oncology Educational Book · doi:10.1200/edbk_199753 · Cited by 20

DNMT3A mutations are over-represented in young adults with NPM1 mutated AML and prompt a distinct co-mutational pattern

Cappelli, L. V., Meggendorfer, M., Dicker, F., Jeromin, S., Hütter, S., Kern, W., Haferlach, T., Haferlach, C., & Höllein, A. (2019) · Leukemia · doi:10.1038/s41375-019-0502-0 · Cited by 20

From Clonal Hematopoiesis to Therapy-Related Myeloid Neoplasms: The Silent Way of Cancer Progression

Gurnari, C., Fabiani, E., Falconi, G., Travaglini, S., Ottone, T., Cristiano, A., & Voso, M. T. (2021) · Biology · doi:10.3390/biology10020128 · Cited by 22

Cell origin–dependent cooperativity of mutant Dnmt3a and Npm1 in clonal hematopoiesis and myeloid malignancy

SanMiguel, J. M., Eudy, E., Loberg, M. A., Miles, L. A., Stearns, T. M., Mistry, J. J., Rauh, M. J., Levine, R. L., & Trowbridge, J. J. (2022) · Blood Advances · doi:10.1182/bloodadvances.2022006968 · Cited by 19

Stat5-deficient hematopoiesis is permissive for Myc-induced B-cell leukemogenesis

Wang, Z., Medrzycki, M., Bunting, S. T., & Bunting, K. D. (2015) · Oncotarget · doi:10.18632/oncotarget.5009 · Cited by 20

Dnmt3a deletion cooperates with the Flt3/ITD mutation to drive leukemogenesis in a murine model

Poitras, J. L., Heiser, D., Li, L., Nguyen, B., Nagai, K., Duffield, A. S., Gamper, C. J., & Small, D. (2016) · Oncotarget · doi:10.18632/oncotarget.11986 · Cited by 20

Clonal Hematopoiesis and Premalignant DiseasesPreprint

Kaner, J. D., Desai, P. M., Mencia-Trinchant, N., Guzmán, M. L., Roboz, G. J., & Hassane, D. C. (2019) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a035675 · Cited by 20

Epigenetic dysregulation in acute myeloid leukemia

Schrezenmeier, J., & Huntly, B. J. P. (2025) · Seminars in Hematology · doi:10.1053/j.seminhematol.2025.06.003 · Cited by 21

Joint representation and visualization of derailed cell states with Decipher

Nazaret, A., Fan, J. L., Lavallée, V., Burdziak, C., Cornish, A. E., Kiseliovas, V., Bowman, R. L., Masilionis, I., Chun, J., Eisman, S. E., et al. (2025) · Genome biology · doi:10.1186/s13059-025-03682-8 · Cited by 16

Stem cell mutations can be detected in myeloma patients years before onset of secondary leukemias

Sridharan, A., Schinke, C., Georgiev, G. I., Ferreira, M. D. S., Thiruthuvanathan, V. J., MacArthur, I. C., Bhagat, T. D., Choudhary, G. S., Aluri, S., Chen, J., et al. (2019) · Blood Advances · doi:10.1182/bloodadvances.2019000731 · Cited by 19

Taking the road less traveled – the therapeutic potential of CBP/β-catenin antagonists

Kahn, M. (2021) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2021.1992386 · Cited by 19

Human acute myeloid leukemia stem cells: evolution of concept

Shin, D. (2022) · Blood Research · doi:10.5045/br.2022.2021221 · Cited by 21

Targeting inflammation in lower-risk MDS

Gonzalez‐Lugo, J. D., & Verma, A. K. (2022) · Hematology · doi:10.1182/hematology.2022000350 · Cited by 19

Epigenetic Modification of Cytosines in Hematopoietic Differentiation and Malignant Transformation

An, J., & Ko, M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24021727 · Cited by 21

Transforming the Niche: The Emerging Role of Extracellular Vesicles in Acute Myeloid Leukaemia Progression

Mendes, M., Monteiro, A. C., Neto, E., Barrias, C. C., Simões, M. S., Duarte, D., & Caires, H. R. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25084430 · Cited by 19

MicroRNA-551b is highly expressed in hematopoietic stem cells and a biomarker for relapse and poor prognosis in acute myeloid leukemia

de Leeuw, D. C., Verhagen, H. J. M. P., Denkers, F., Kavelaars, F. G., Valk, P. J. M., Schuurhuis, G. J., Ossenkoppele, G. J., & Smit, L. (2015) · Leukemia · doi:10.1038/leu.2015.160 · Cited by 19

Sequential analysis of 18 genes in polycythemia vera and essential thrombocythemia reveals an association between mutational status and clinical outcome

Paz, D. L., Chauveau, A., Boyer, F., Buors, C., Samaison, L., Cottin, L., Seegers, V., Férec, C., Maréchal, C. L., Guéguen, P., et al. (2016) · Genes Chromosomes and Cancer · doi:10.1002/gcc.22437 · Cited by 21

Residual disease detection using targeted parallel sequencing predicts relapse in cytogenetically normal acute myeloid leukemia

Gaksch, L., Kashofer, K., Heitzer, E., Quehenberger, F., Daga, S., Hofer, S., Halbwedl, I., Graf, R., Krisper, N., Höefler, G., et al. (2017) · American Journal of Hematology · doi:10.1002/ajh.24922 · Cited by 19

Mutation profiling of 16 candidate genes in de novo acute myeloid leukemia patients

Zhang, Y., Wang, F., Chen, X., Liu, W., Fang, J., Wang, M., Teng, W., Cao, P., & Liu, H. (2018) · Frontiers of Medicine · doi:10.1007/s11684-018-0616-1 · Cited by 19

Cell-intrinsic depletion of Aml1-ETO-expressing pre-leukemic hematopoietic stem cells by K-Ras activating mutation

Genua, C. D., Norfo, R., Rodríguez-Meira, A., Wen, W. X., Drissen, R., Booth, C. A. G., Povinelli, B. J., Repapi, E., Gray, N., Carrelha, J., et al. (2019) · Haematologica · doi:10.3324/haematol.2018.205351 · Cited by 18

Hematopoietic stem cells: self-renewal and expansion

Li, Z., He, X., & Li, L. (2019) · Current Opinion in Hematology · doi:10.1097/moh.0000000000000506 · Cited by 20

Single-cell sequencing in hematology

Brierley, C. K., & Mead, A. J. (2019) · Current Opinion in Oncology · doi:10.1097/cco.0000000000000613 · Cited by 19

Oncogenic N-Ras Mitigates Oxidative Stress–Induced Apoptosis of Hematopoietic Stem Cells

Ney, G. M., Yang, K. B., Ng, V., Liu, L., Zhao, M., Kuk, W., Alaka, L., Sampang, L., Ross, A., Jones, M. A., et al. (2021) · Cancer Research · doi:10.1158/0008-5472.can-20-0118 · Cited by 19

Epigenetic Control of Haematopoietic Stem Cell Aging and Its Clinical Implications

Choudry, F., & Frontini, M. (2015) · Stem Cells International · doi:10.1155/2016/5797521 · Cited by 19

CD82 supports survival of childhood acute myeloid leukemia cells via activation of Wnt/β-catenin signaling pathway

Ji, H., Chen, L., Xing, Y., Li, S., Dai, J., Zhao, P., & Wang, Y. (2019) · Pediatric Research · doi:10.1038/s41390-019-0370-3 · Cited by 19

Whole-genome analysis reveals unexpected dynamics of mutant subclone development in a patient with JAK2-V617F-positive chronic myeloid leukemia

Sloma, I., Mitjavila‐Garcia, M. T., Feraud, O., Griscelli, F., Oudrhiri, N., Marsafy, S. E., Gobbo, E., Divers, D., Proust, A., Smadja, D. M., et al. (2017) · Experimental Hematology · doi:10.1016/j.exphem.2017.05.007 · Cited by 19

CML - Not only BCR-ABL1 matters

Rinke, J., Hochhaus, A., & Ernst, T. (2020) · Best Practice & Research Clinical Haematology · doi:10.1016/j.beha.2020.101194 · Cited by 18

Integrative Genomic Analysis Reveals Cancer-Associated Gene Mutations in Chronic Myeloid Leukemia Patients with Resistance or Intolerance to Tyrosine Kinase Inhibitor

Wu, W., Xu, N., Zhou, X., Liu, L., Tan, Y., Luo, J. D., Huang, J., Qin, J., Wang, J., Li, Z., et al. (2020) · OncoTargets and Therapy · doi:10.2147/ott.s257661 · Cited by 17

Targeting stem cells in myelodysplastic syndromes and acute myeloid leukemia

Woll, P. S., Yoshizato, T., Hellström‐Lindberg, E., Fioretos, T., Ebert, B. L., & Jacobsen, S. E. W. (2022) · Journal of Internal Medicine · doi:10.1111/joim.13535 · Cited by 15

Human ASXL1-Mutant Hematopoiesis Is Driven by a Truncated Protein Associated with Aberrant Deubiquitination of H2AK119

Köhnke, T., Nuno, K. A., Alder, C. C., Gars, E. J., Phan, P., Fan, A. C., & Majeti, R. (2024) · Blood Cancer Discovery · doi:10.1158/2643-3230.bcd-23-0235 · Cited by 23

Measurable residual disease monitoring by ddPCR in the early posttransplant period complements the traditional MFC method to predict relapse after HSCT in AML/MDS: a multicenter retrospective study

Chen, W., Huang, J., Zhao, Y., Huang, L., Yuan, Z., Xu, X., Xu, X., Shi, J., Luo, Y., Yu, J., et al. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-05114-w · Cited by 18

Distribution of mutations in DNMT3A gene and the suitability of mutations in R882 codon for MRD monitoring in patients with AML

Ježíšková, I., Musilová, M., Čulen, M., Foltánková, V., Dvořáková, D., Mayer, J., & Ráčil, Z. (2015) · International Journal of Hematology · doi:10.1007/s12185-015-1856-3 · Cited by 18

New Strategies in Acute Myelogenous Leukemia: Leukemogenesis and Personalized Medicine

Gojo, I., & Karp, J. E. (2014) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-14-0900 · Cited by 18

MDS Is a Stem Cell Disorder After All

Jaiswal, S., & Ebert, B. L. (2014) · Cancer Cell · doi:10.1016/j.ccr.2014.06.001 · Cited by 18

Mechanisms underlying the heterogeneity of myelodysplastic syndromes

Dussiau, C., & Fontenay, M. (2017) · Experimental Hematology · doi:10.1016/j.exphem.2017.10.004 · Cited by 19

The rocky road to personalized medicine in acute myeloid leukaemia

Brinda, B. J., Khan, I., Parkin, B. L., & Koenig, H. (2018) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.13478 · Cited by 18

Tracking preleukemic cells in vivo to reveal the sequence of molecular events in radiation leukemogenesis

Verbiest, T., Finnon, R., Brown, N., Cruz-Garcia, L., Finnon, P., O’Brien, G., Ross, E., Bouffler, S. D., Scudamore, C. L., & Badie, C. (2018) · Leukemia · doi:10.1038/s41375-018-0085-1 · Cited by 18

Gata2 deficiency delays leukemogenesis while contributing to aggressive leukemia phenotype in Cbfb-MYH11 knockin mice

Saida, S., Zhen, T., Kim, E., Yu, K., Lopez, G., McReynolds, L. J., & Liu, P. (2019) · Leukemia · doi:10.1038/s41375-019-0605-7 · Cited by 18

Defining minimal residual disease in acute myeloid leukemia: which platforms are ready for “prime time”?

Grimwade, D. J., & Freeman, S. D. (2014) · Hematology · doi:10.1182/asheducation.v2014.1.222.3884425 · Cited by 17

Genetic mutations in epigenetic modifiers as therapeutic targets in acute myeloid leukemia

Nebbioso, A., Benedetti, R., Conte, M., Iside, C., & Altucci, L. (2015) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2015.1051728 · Cited by 18

RNA modification in normal hematopoiesis and hematologic malignancies

Chen, X., Yuan, Y., Zhou, F., Li, L., Pu, J., & Jiang, X. (2024) · MedComm · doi:10.1002/mco2.787 · Cited by 17

Should minimal residual disease guide therapy in AML?

Paietta, E. M. (2015) · Best Practice & Research Clinical Haematology · doi:10.1016/j.beha.2015.10.006 · Cited by 17

Identification of the global miR-130a targetome reveals a role for TBL1XR1 in hematopoietic stem cell self-renewal and t(8;21) AML

Krivdova, G., Voisin, V., Schoof, E. M., Marhon, S. A., Murison, A., McLeod, J. L., Gabra, M., Zeng, A. G. X., Aigner, S., Yee, B. A., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.110481 · Cited by 17

A patent review of pharmaceutical and therapeutic applications of oxadiazole derivatives for the treatment of chronic diseases (2013–2021)

Hassan, A., Khan, A. H., Saleem, F., Ahmad, H., & Khan, K. M. (2022) · Expert Opinion on Therapeutic Patents · doi:10.1080/13543776.2022.2116312 · Cited by 17

Cellular Reprogramming Allows Generation of Autologous Hematopoietic Progenitors From AML Patients That Are Devoid of Patient-Specific Genomic Aberrations

Salci, K. R., Lee, J., Laronde, S., Dingwall, S., Kushwah, R., Fiebig‐Comyn, A., Leber, B. F., Foley, R., Cin, A. D., & Bhatia, M. (2015) · Stem Cells · doi:10.1002/stem.1994 · Cited by 17

Mouse acute leukemia develops independent of self-renewal and differentiation potentials in hematopoietic stem and progenitor cells.

Dong, F., Bai, H.-T., Wang, X.-F., Zhang, S.-S., Wang, Z., Xie, M., Zhang, S., Wang, J., Sha, H., Cheng, T., et al. (2019) · Blood Advances · doi:10.1182/bloodadvances.2018022400 · Cited by 17

Differential response to cytotoxic therapy explains treatment dynamics of acute myeloid leukaemia patients: insights from a mathematical modelling approach

Hoffmann, H., Thiede, C., Glauche, I., Bornhaeuser, M., & Roeder, I. (2020) · Journal of The Royal Society Interface · doi:10.1098/rsif.2020.0091 · Cited by 17

Preleukemic and leukemic evolution at the stem cell level

Stauber, J., Greally, J. M., & Steidl, U. G. (2020) · Blood · doi:10.1182/blood.2019004397 · Cited by 20

Beyond regulations at DNA levels: A review of epigenetic therapeutics targeting cancer stem cells

Zhang, S., Gong, Y., Li, C., Yang, W., & Li, L. (2020) · Cell Proliferation · doi:10.1111/cpr.12963 · Cited by 18

Physioxia-induced downregulation of Tet2 in hematopoietic stem cells contributes to enhanced self-renewal

Aljoufi, A., Zhang, C., Ropa, J. P., Chang, W., Palam, L. R., Cooper, S. H., Ramdas, B., Capitano, M. L., Broxmeyer, H. E., & Kapur, R. (2022) · Blood · doi:10.1182/blood.2022015499 · Cited by 20

Premalignant cell dynamics in indolent B-cell malignancies

Milpied, P., Nadel, B., & Roulland, S. (2015) · Current Opinion in Hematology · doi:10.1097/moh.0000000000000159 · Cited by 19

Clinical characteristics and prognosis of acute myeloid leukemia associated with DNA-methylation regulatory gene mutations

Ryotokuji, T., Yamaguchi, H., Ueki, T., Usuki, K., Kurosawa, S., Kobayashi, Y., Kawata, E., Tajika, K., Gomi, S., Kanda, J., et al. (2016) · Haematologica · doi:10.3324/haematol.2016.143073 · Cited by 17

Full-length mutation search of the TP53 gene in acute myeloid leukemia has increased significance as a prognostic factor

Terada, K., Yamaguchi, H., Ueki, T., Usuki, K., Kobayashi, Y., Tajika, K., Gomi, S., Kurosawa, S., Miyadera, K., Tokura, T., et al. (2017) · Annals of Hematology · doi:10.1007/s00277-017-3143-2 · Cited by 17

Preleukemic and second-hit mutational events in an acute myeloid leukemia patient with a novel germline RUNX1 mutation

Ng, I. K., Lee, J., Ng, C., Kosmo, B., Chiu, L., Seah, E., Mok, M. M. H., Tan, K. M. L., Osato, M., Chng, W. J., et al. (2018) · Biomarker Research · doi:10.1186/s40364-018-0130-2 · Cited by 17

The Making of Leukemia

González‐Herrero, I., Rodríguez-Hernández, G., Luengas‐Martinez, A., Isidro-Hernández, M., Jiménez, R., Cenador, M. B. G., García‐Criado, F. J., Sánchez-Garcı́a, I., & Vicente‐Dueñas, C. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19051494 · Cited by 18

Restricted cell cycle is essential for clonal evolution and therapeutic resistance of pre-leukemic stem cells

Tremblay, C. S., Saw, J., Chiu, S. K., Wong, N. C., Tsyganov, K., Ghotb, S., Graham, A. N., Yan, F., Guirguis, A. A., Sonderegger, S., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-06021-7 · Cited by 17

The Impact of the Cellular Origin in Acute Myeloid Leukemia: Learning From Mouse Models

Fisher, J. N., Kalleda, N., Stavropoulou, V., & Schwaller, J. (2019) · HemaSphere · doi:10.1097/hs9.0000000000000152 · Cited by 19

Single cell RNA sequencing improves the next generation of approaches to AML treatment: challenges and perspectives

Khosroabadi, Z., Azaryar, S., Dianat‐Moghadam, H., Amoozgar, Z., & Sharifi, M. (2025) · Molecular Medicine · doi:10.1186/s10020-025-01085-w · Cited by 18

Super enhancers: Pathogenic roles and potential therapeutic targets for acute myeloid leukemia (AML)

Cao, Z., Shu, Y., Wang, J., Wang, C., Feng, T., Li, Y., Shao, J., & Zou, L. (2022) · Genes & Diseases · doi:10.1016/j.gendis.2022.01.006 · Cited by 16

Multi-target measurable residual disease assessed by error-corrected sequencing in patients with acute myeloid leukemia: An ALFA study

Hirsch, P., Lambert, J., Bucci, M., Deswarte, C., Boudry, A., Lambert, J., Fenwarth, L., Micol, J., Terré, C., Celli‐Lebras, K., et al. (2024) · Blood Cancer Journal · doi:10.1038/s41408-024-01078-8 · Cited by 16

Contrasting Roles for C/EBPα and Notch in Irradiation-Induced Multipotent Hematopoietic Progenitor Cell Defects

Fleenor, C. J., Rozhok, A. I., Zaberezhnyy, V., Mathew, D., Kim, J., Tan, A. C., Bernstein, I. D., & DeGregori, J. V. (2014) · Stem Cells · doi:10.1002/stem.1936 · Cited by 17

The routes for transformation of follicular lymphoma

Okosun, J., Montoto, S., & Fitzgibbon, J. (2016) · Current Opinion in Hematology · doi:10.1097/moh.0000000000000255 · Cited by 16

Clonal hematopoiesis: a “CHIP” off the old block

Lichtman, M. A. (2015) · Blood · doi:10.1182/blood-2015-05-644690 · Cited by 16

Epigenetically induced ectopic expression of UNCX impairs the proliferation and differentiation of myeloid cells

Daniele, G., Simonetti, G., Fusilli, C., Iacobucci, I., Lonoce, A., Palazzo, A. J., Lomiento, M., Mammoli, F., Marsano, R. M., Marasco, E., et al. (2017) · Haematologica · doi:10.3324/haematol.2016.163022 · Cited by 16

Gene Mutations as Emerging Biomarkers and Therapeutic Targets for Relapsed Acute Myeloid Leukemia

Aziz, H., Ping, C. Y., Alias, H., Mutalib, N. A., & Jamal, R. A. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00897 · Cited by 16

Harnessing the potential of epigenetic therapies for childhood acute myeloid leukemia

Newcombe, A., Gibson, B. E. S., & Keeshan, K. (2018) · Experimental Hematology · doi:10.1016/j.exphem.2018.03.008 · Cited by 16

Clonal approaches to understanding the impact of mutations on hematologic disease development

Nangalia, J., Mitchell, E., & Green, A. R. (2019) · Blood · doi:10.1182/blood-2018-11-835405 · Cited by 19

Analysis of the clinical impact of NPM1 mutant allele burden in a large cohort of younger adult patients with acute myeloid leukaemia

Linch, D. C., Hills, R. K., Burnett, A. K., Russell, N. H., & Gale, R. E. (2019) · British Journal of Haematology · doi:10.1111/bjh.16239 · Cited by 16

Effects of signaling pathway inhibitors on hematopoietic stem cells

Jiang, Y., Xu, Z., Ma, N., Yin, L., Hao, C., & Li, J. (2020) · Molecular Medicine Reports · doi:10.3892/mmr.2020.11647 · Cited by 16

Posttransplant blockade of CXCR4 improves leukemia complete remission rates and donor stem cell engraftment without aggravating GVHD

Su, L., Fang, M.-H., Zou, J., Gao, S., Gu, X.-Y., Meng, X., Wang, X., Hu, Z., & Yang, Y. (2021) · Cellular and Molecular Immunology · doi:10.1038/s41423-021-00775-9 · Cited by 17

Molecular Pathways in Clonal Hematopoiesis: From the Acquisition of Somatic Mutations to Transformation into Hematologic Neoplasm

Gaulin, C., Kelemen, K., & Yi, C. A. (2022) · Life · doi:10.3390/life12081135 · Cited by 16

Abnormal RNA splicing and genomic instability after induction of DNMT3A mutations by CRISPR/Cas9 gene editing

Banaszak, L. G., Giudice, V., Zhao, X., Wu, Z., Gao, S., Hosokawa, K. T., Keyvanfar, K., Townsley, D. M., Gutierrez‐Rodrigues, F., Ibanez, M. D. P. F., et al. (2018) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2017.12.002 · Cited by 17

Durable remission with ruxolitinib in a chronic neutrophilic leukemia patient harboring a truncation and membrane proximal CSF3R compound mutation

Hinze, A., Rinke, J., Hochhaus, A., & Ernst, T. (2020) · Annals of Hematology · doi:10.1007/s00277-020-04152-w · Cited by 16

Mitochondria in Cancer Stem Cells: From an Innocent Bystander to a Central Player in Therapy Resistance

Garimella, S. V., Gampa, S. C., & Chaturvedi, P. (2023) · Stem Cells and Cloning Advances and Applications · doi:10.2147/sccaa.s417842 · Cited by 16

Chromatin Dynamics during Differentiation of Myeloid Cells

Schönheit, J., Leutz, A., & Rosenbauer, F. (2014) · Journal of Molecular Biology · doi:10.1016/j.jmb.2014.08.015 · Cited by 15

The AML Salad Bowl

Duque‐Afonso, J., & Cleary, M. L. (2014) · Cancer Cell · doi:10.1016/j.ccr.2014.03.002 · Cited by 15

The Genomic and Epigenomic Landscapes of AML

Mazzarella, L., Riva, L., Luzi, L., Ronchini, C., & Pelicci, P. G. (2014) · Seminars in Hematology · doi:10.1053/j.seminhematol.2014.08.007 · Cited by 15

Regulation of Hematopoietic Stem Cell Self-Renewal and Leukemia Maintenance by the PI3K-mTORC1 Pathway

Ghosh, J., & Kapur, R. (2016) · Current Stem Cell Reports · doi:10.1007/s40778-016-0067-z · Cited by 15

Preleukemia and Leukemia-Initiating Cell Activity in inv(16) Acute Myeloid Leukemia

Pulikkan, J. A., & Castilla, L. H. (2018) · Frontiers in Oncology · doi:10.3389/fonc.2018.00129 · Cited by 15

Murine models based on acute myeloid leukemia-initiating stem cells xenografting

Mambet, C., Chivu‐Economescu, M., Matei, L., Necula, L. G., Dragu, D., Bleoţu, C., & Diaconu, C. C. (2018) · World Journal of Stem Cells · doi:10.4252/wjsc.v10.i6.57 · Cited by 15

Escape hematopoiesis by HLA-B5401-lacking hematopoietic stem progenitor cells in men with acquired aplastic anemia

El‐Badry, M., Mizumaki, H., Hosokawa, K. T., Espinoza, J. L., Nakagawa, N., Chonabayashi, K., Yoshida, Y., Katagiri, T., Hosomichi, K., Zaimoku, Y., et al. (2019) · Haematologica · doi:10.3324/haematol.2018.210856 · Cited by 15

Single-Cell Epigenomics in Cancer: Charting a Course to Clinical Impact

Bond, D. R., Uddipto, K., Enjeti, A. K., & Lee, H. J. (2020) · Epigenomics · doi:10.2217/epi-2020-0046 · Cited by 15

All-trans retinoic acid in non-promyelocytic acute myeloid leukemia: driver lesion dependent effects on leukemic stem cells

Nguyen, C. H., Grandits, A. M., Purton, L. E., Sill, H., & Wieser, R. (2020) · Cell Cycle · doi:10.1080/15384101.2020.1810402 · Cited by 17

Targeted Therapies for the Evolving Molecular Landscape of Acute Myeloid Leukemia

Ahmadmehrabi, K., Haque, A. R., Aleem, A., Griffiths, E. A., & Roloff, G. W. (2021) · Cancers · doi:10.3390/cancers13184646 · Cited by 14

Persistence of pre-leukemic clones during first remission and risk of relapse in acute myeloid leukemia

Rothenberg‐Thurley, M., Amler, S., Göerlich, D., Köhnke, T., Konstandin, N. P., Schneider, S., Sauerland, M. C., Herold, T., Hubmann, M., Ksienzyk, B., et al. (2017) · Leukemia · doi:10.1038/leu.2017.350 · Cited by 15

DNMT3A: the DioNysian MonsTer of acute myeloid leukaemia

O’Brien, E. C., Brewin, J. N., & Chevassut, T. J. T. (2014) · Therapeutic Advances in Hematology · doi:10.1177/2040620714554538 · Cited by 15

New Insights in AML Biology From Genomic Analysis

Perry, A. M., & Attar, E. C. (2014) · Seminars in Hematology · doi:10.1053/j.seminhematol.2014.08.005 · Cited by 15

Frequent reconstitution of IDH2R140Q mutant clonal multilineage hematopoiesis following chemotherapy for acute myeloid leukemia

Wiseman, D. H., Williams, E. L., Wilks, D. P., Leong, H. S., Somerville, T. D. D., Dennis, M. W., Struys, E. A., Bakkali, A., Salomons, G. S., & Somervaille, T. C. P. (2016) · Leukemia · doi:10.1038/leu.2016.93 · Cited by 15

Heterogeneous leukemia stem cells in myeloid blast phase chronic myeloid leukemia

Kinstrie, R., Karamitros, D., Goardon, N., Morrison, H., Hamblin, M., Robinson, L., Clark, R. E., Copland, M., & Vyas, P. (2016) · Blood Advances · doi:10.1182/bloodadvances.2016000810 · Cited by 15

GATA2 Inhibition Sensitizes Acute Myeloid Leukemia Cells to Chemotherapy

Li, Y., Sun, H., Cao, Y., Xuan, B., Fan, Y., Sheng, H., & Zhuang, W. (2017) · PLoS ONE · doi:10.1371/journal.pone.0170630 · Cited by 15

Persistence of leukaemic ancestors

Potter, N. E., & Greaves, M. F. (2014) · Nature · doi:10.1038/nature13056 · Cited by 7

DNMT3a Mutations Define a Pre-Leukemic Stem Cell Reservoir In Human Acute Myeloid Leukemia

Shlush, L. I., Zandi, S., Mitchell, A., Chen, W. C., Jessica, M., Doedens, M., Medeiros, J. J. F., Marke, R., John, M. J., Hudson, T. J., et al. (2013) · Blood · doi:10.1182/blood.v122.21.487.487 · Cited by 4

Abstract 3303: Clonal evolution of pre-leukemic hematopoietic stem cells precedes human acute myeloid leukemia

Jan, M., Snyder, T. M., Corces, M. R., Weissman, I. L., Quake, S. R., & Majeti, R. (2012) · Cancer Research · doi:10.1158/1538-7445.am2012-3303

Clonal evolution of pre-leukemic hematopoietic stem cells precedes human acute myeloid leukemia

Majeti, R. (2014) · Best Practice & Research Clinical Haematology · doi:10.1016/j.beha.2014.10.003 · Cited by 32

Abstract SY35-01: Clonal evolution of pre-leukemic hematopoietic stem cells precedes human acute myeloid leukemia

Jan, M., Snyder, T. M., Corces, M. R., Quake, S. R., Weissman, I. L., & Majeti, R. (2012) · Cancer Research · doi:10.1158/1538-7445.am2012-sy35-01 · Cited by 2