Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia

Genetic Alterations during Colorectal-Tumor Development

Vogelstein, B., Fearon, E. R., Hamilton, S. R., Kern, S. E., Preisinger, A. C., Leppert, M., de Vries-Smits, A. M. M., & Bos, J. L. (1988) · New England Journal of Medicine · doi:10.1056/nejm198809013190901 · Cited by 6,704

Genomic and Epigenomic Landscapes of Adult De Novo Acute Myeloid Leukemia

The Cancer Genome Atlas Research Network (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1301689 · Cited by 5,078

Mutational landscape and significance across 12 major cancer types

Kandoth, C., McLellan, M. D., Vandin, F., Ye, K., Niu, B., Lu, C., Xie, M., Zhang, Q., McMichael, J. F., Wyczalkowski, M. A., et al. (2013) · Nature · doi:10.1038/nature12634 · Cited by 4,419

Clonal evolution in cancer

Greaves, M., & Maley, C. C. (2012) · Nature · doi:10.1038/nature10762 · Cited by 3,162

Distant metastasis occurs late during the genetic evolution of pancreatic cancer

Yachida, S., Jones, S., Bozic, I., Antal, T., Leary, R., Fu, B., Kamiyama, M., Hruban, R. H., Eshleman, J. R., Nowak, M. A., et al. (2010) · Nature · doi:10.1038/nature09515 · Cited by 2,502

ELDA: Extreme limiting dilution analysis for comparing depleted and enriched populations in stem cell and other assays

Hu, Y., & Smyth, G. K. (2009) · Journal of Immunological Methods · doi:10.1016/j.jim.2009.06.008 · Cited by 2,084

Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing

Ding, L., Ley, T. J., Larson, D. E., Miller, C. A., Koboldt, D. C., Welch, J. S., Ritchey, J. K., Young, M. A., Lamprecht, T., McLellan, M. D., et al. (2012) · Nature · doi:10.1038/nature10738 · Cited by 1,993

Prognostic Relevance of Integrated Genetic Profiling in Acute Myeloid Leukemia

Patel, J. P., Gönen, M., Figueroa, M. E., Fernandez, H. F., Sun, Z., Racevskis, J., Vlierberghe, P. V., Dolgalev, I., Thomas, S., Aminova, O., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1112304 · Cited by 1,990

DNMT3A Mutations in Acute Myeloid Leukemia

Ley, T. J., Ding, L., Walter, M. J., McLellan, M. D., Lamprecht, T., Larson, D. E., Kandoth, C., Payton, J. E., Baty, J., Welch, J., et al. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa1005143 · Cited by 1,983

The patterns and dynamics of genomic instability in metastatic pancreatic cancer

Campbell, P. J., Yachida, S., Mudie, L. J., Stephens, P. J., Pleasance, E. D., Stebbings, L. A., Morsberger, L. A., Latimer, C., McLaren, S., Lin, M.-L., et al. (2010) · Nature · doi:10.1038/nature09460 · Cited by 1,317

Epigenetics in Hematological Malignancies

Cruz-Rodríguez, N., Cómbita, A. L., & Zabaleta, J. (2018) · Methods in molecular biology · doi:10.1007/978-1-4939-8751-1_5 · Cited by 16

Expression of CD25 fluctuates in the leukemia-initiating cell population of CD25-positive AML

Kageyama, Y., Miwa, H., Arakawa, R., Tawara, I., Ohishi, K., Masuya, M., Nakase, K., & Katayama, N. (2018) · PLoS ONE · doi:10.1371/journal.pone.0209295 · Cited by 16

The Changing Landscape of Treatment in Acute Myeloid Leukemia

Koenig, K. L., Mims, A. S., Levis, M. J., & Horowitz, M. M. (2020) · American Society of Clinical Oncology Educational Book · doi:10.1200/edbk_279129 · Cited by 15

The small inhibitor WM-1119 effectively targets KAT6A-rearranged AML, but not KMT2A-rearranged AML, despite shared KAT6 genetic dependency

Sheridan, M., Maqbool, M. A., Largeot, A., Clayfield, L., Xu, J., Moncaut, N., Sellers, R., Whittle, J., Paggetti, J., Iqbal, M., et al. (2024) · Journal of Hematology & Oncology · doi:10.1186/s13045-024-01610-0 · Cited by 14

Genomic mutation patterns and prognostic value in de novo and secondary acute myeloid leukemia: A multicenter study from China

Dou, X., Dan, C., Zhang, D., Zhou, H., He, R., Zhou, G., Zhu, Y., Fu, N., Niu, B., Xu, S., et al. (2024) · International Journal of Cancer · doi:10.1002/ijc.35125 · Cited by 14

Quantitative detection of DNMT3A R882H mutation in acute myeloid leukemia

Berenstein, R., Blau, I. W., Suckert, N., Baldus, C. D., Pezzutto, A., Dörken, B., & Blau, O. (2015) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-015-0173-2 · Cited by 14

Azacitidine combined with the selective FLT3 kinase inhibitor crenolanib disrupts stromal protection and inhibits expansion of residual leukemia-initiating cells in FLT3-ITD AML with concurrent epigenetic mutations

Garz, A.-K., Wolf, S., Grath, S., Gaidzik, V. I., Habringer, S., Vick, B., Rudelius, M., Ziegenhain, C., Herold, S., Weickert, M., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.21877 · Cited by 15

Revisiting CLEC 12A as leukaemic stem cell marker in AML : highlighting the necessity of precision diagnostics in patients eligible for targeted therapy

Bill, M., Aggerholm, A., Kjeldsen, E., Roug, A. S., Hokland, P., & Nederby, L. (2018) · British Journal of Haematology · doi:10.1111/bjh.15711 · Cited by 14

Targeted sequencing aids in identifying clonality in chronic myelomonocytic leukemia

Hwang, S. M., Kim, S., Nam, Y., Kim, J., Kim, S., Ahn, Y., Park, Y., Yoon, S., Shin, S., Kwon, S., et al. (2019) · Leukemia Research · doi:10.1016/j.leukres.2019.106190 · Cited by 14

Clonal hierarchy of main molecular lesions in acute myeloid leukaemia

Herudková, Z., Čulen, M., Folta, A., Ježíšková, I., Černá, J., Loja, T., Tom, N., Šmejkal, J., Semerád, L., Dvořáková, D., et al. (2019) · British Journal of Haematology · doi:10.1111/bjh.16341 · Cited by 15

Identification of relapse‐associated gene mutations by next‐generation sequencing in low‐risk acute myeloid leukaemia patients

Prieto-Conde, I., Jiménez, C., García‐Álvarez, M., Ramos, F., Medina, A., Cuello, R., Balanzategui, A., Alonso, J. M., Sarasquete, M. E., Queizán, J. A., et al. (2020) · British Journal of Haematology · doi:10.1111/bjh.16420 · Cited by 14

Epigenetic landscape analysis of lncRNAs in acute myeloid leukemia with DNMT3A mutations

Dai, Y., Hu, F., He, S., & Wang, Y. (2020) · Annals of Translational Medicine · doi:10.21037/atm.2020.02.143 · Cited by 13

Novel Gene Signature Reveals Prognostic Model in Acute Myeloid Leukemia

Qu, Y., Zhang, S., Qu, Y., Guo, H., Wang, S., Wang, X., Huang, T., & Zhou, H. (2020) · Frontiers in Genetics · doi:10.3389/fgene.2020.566024 · Cited by 14

Studying clonal evolution of myeloid malignancies using induced pluripotent stem cells

Doulatov, S. R., & Papapetrou, E. P. (2020) · Current Opinion in Hematology · doi:10.1097/moh.0000000000000620 · Cited by 15

Allogeneic hematopoietic stem cell transplantation could improve the survival of acute myeloid leukemia patients with ASXL1 mutations

Zhou, L., An, J., Hou, C. J., Ding, Z., Qiu, H., Tang, X., Sun, A., Chen, S., Xu, Y., Liu, T., et al. (2021) · Hematology · doi:10.1080/16078454.2021.1905356 · Cited by 14

Understanding Normal and Pathological Hematopoietic Stem Cell Biology Using Mathematical Modelling

Brunetti, M., Mackey, M. C., & Craig, M. (2021) · Current Stem Cell Reports · doi:10.1007/s40778-021-00191-9 · Cited by 17

DNA Methylation and Intra-Clonal Heterogeneity: The Chronic Myeloid Leukemia Model

Lebecque, B., Bourgne, C., Vidal, V., & Berger, M. G. (2021) · Cancers · doi:10.3390/cancers13143587 · Cited by 15

Leukemic Stem Cell: A Mini-Review on Clinical Perspectives

Barreto, I. V., Pessoa, F. M. C. D. P., Machado, C. B., Pantoja, L. D. C., Ribeiro, R. M., Lopes, G. S., de Moraes, M. E. A., de Moraes, M. O., de Souza, L. E. B., Burbano, R. M. R., et al. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.931050 · Cited by 14

The Concept of Cancer Stem Cells: Elaborating on ALDH1B1 as an Emerging Marker of Cancer Progression

Tsochantaridis, I., Roupas, A., Mohlin, S., Pappa, A., & Voulgaridou, G.-P. (2023) · Life · doi:10.3390/life13010197 · Cited by 14

Molecular Pathogenesis of Peripheral T Cell Lymphoma

Sakata‐Yanagimoto, M., & Chiba, S. (2015) · Current Hematologic Malignancy Reports · doi:10.1007/s11899-015-0289-7 · Cited by 14

I Walk the Line: How to Tell MDS From Other Bone Marrow Failure Conditions

Gondek, L. P., & Dezern, A. E. (2014) · Current Hematologic Malignancy Reports · doi:10.1007/s11899-014-0224-3 · Cited by 14

Cancer stem cells and tumor immunoediting: putting two and two together

Bhatia, A., & Kumar, Y. (2016) · Expert Review of Clinical Immunology · doi:10.1586/1744666x.2016.1159133 · Cited by 14

Clonal analysis of stem cells in differentiation and disease

Colom, B., & Jones, P. H. (2016) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2016.07.002 · Cited by 13

Cellular and molecular architecture of hematopoietic stem cells and progenitors in genetic models of bone marrow failure

Heidemann, S. C., Bursic, B., Zandi, S., Li, H., Abelson, S., Klaassen, R. J., Abish, S. B., Rayar, M. S., Breakey, V. R., Moshiri, H., et al. (2020) · JCI Insight · doi:10.1172/jci.insight.131018 · Cited by 15

Epigenetics in a Spectrum of Myeloid Diseases and Its Exploitation for Therapy

Maher, M., Diesch, J., Pannérer, M.-M. L., & Buschbeck, M. (2021) · Cancers · doi:10.3390/cancers13071746 · Cited by 14

Human haematopoietic stem cells remember inflammatory stress

Zeng, A. G. X., Nagree, M. S., Jakobsen, N. A., Shah, S., Varesi, A., Kang, J. R. W., Murison, A., Cheong, J.-G., Turkalj, S., Zhang, X., et al. (2026) · Nature · doi:10.1038/s41586-026-10522-7 · Cited by 10

Put in a “Ca2+ll” to Acute Myeloid Leukemia

Lewuillon, C., Laguillaumie, M.-O., Quesnel, B., Idziorek, T., Touil, Y. S., & Lemonnier, L. (2022) · Cells · doi:10.3390/cells11030543 · Cited by 16

Crosstalk between DNA methylation and hypoxia in acute myeloid leukaemia

Humphries, S., Bond, D. R., Germon, Z. P., Keely, S., Enjeti, A. K., Dun, M. D., & Lee, H. J. (2023) · Clinical Epigenetics · doi:10.1186/s13148-023-01566-x · Cited by 15

Interventional probability of causation (IPoC) with epidemiological and partial mechanistic evidence: benzene vs. formaldehyde and acute myeloid leukemia (AML)

Cox, L. A., Thompson, W. J., & Mundt, K. A. (2024) · Critical Reviews in Toxicology · doi:10.1080/10408444.2024.2337435 · Cited by 15

In vivo models of subclonal oncogenesis and dependency in hematopoietic malignancy

Bowman, R. L., Dunbar, A. J., Mishra, T., Xiao, W., Waarts, M., Maestre, I. F., Eisman, S. E., Cai, L., Mowla, S., Shah, N., et al. (2024) · Cancer Cell · doi:10.1016/j.ccell.2024.10.009 · Cited by 14

Novel single-cell technologies in acute myeloid leukemia research

Gupta, S. D., & Sachs, Z. (2017) · Translational research · doi:10.1016/j.trsl.2017.07.007 · Cited by 14

Immune modulation by a cellular network of mesenchymal stem cells and breast cancer cell subsets: Implication for cancer therapy

Eltoukhy, H. S., Sinha, G., Moore, C. A., Sandiford, O. A., & Rameshwar, P. (2017) · Cellular Immunology · doi:10.1016/j.cellimm.2017.07.011 · Cited by 13

Pilot Study of an Integrative New Tool for Studying Clinical Outcome Discrimination in Acute Leukemia

Garay, M. J. G., Niño-Joya, A. F., Bolaños, N. I., Abenoza, L., Quintero, G., Ibarra, H., González, J. M., Akle, V., & Garavito-Aguilar, Z. V. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.00245 · Cited by 13

High expression of miR-25 predicts favorable chemotherapy outcome in patients with acute myeloid leukemia

Niu, M., Yuan, F., Zhang, N., Shao, T., Zhang, H., Wang, R., Yao, Y., Yao, R., Wu, Q., Cao, J., et al. (2019) · Cancer Cell International · doi:10.1186/s12935-019-0843-9 · Cited by 13

The lysine methyltransferase SMYD2 is required for normal lymphocyte development and survival of hematopoietic leukemias

Brown, M. A., Edwards, M. A., Alshiraihi, I., Geng, H., Dekker, J. D., & Tucker, H. O. (2020) · Genes and Immunity · doi:10.1038/s41435-020-0094-8 · Cited by 12

Evolving insights on histone methylome regulation in human acute myeloid leukemia pathogenesis and targeted therapy

Boila, L. D., & Sengupta, A. (2020) · Experimental Hematology · doi:10.1016/j.exphem.2020.09.189 · Cited by 12

Mitochondrial calcium homeostasis in hematopoietic stem cell: Molecular regulation of quiescence, function, and differentiation

Bonora, M., Kahsay, A., & Pinton, P. (2021) · International review of cytology · doi:10.1016/bs.ircmb.2021.05.003 · Cited by 16

Validation, Implementation, and Clinical Impact of the Oncomine Myeloid Targeted-Amplicon DNA and RNA Ion Semiconductor Sequencing Assay

Ferrone, C. K., Wong, H., Semenuk, L., Werunga, B., Snetsinger, B., Zhang, X., Zhang, G. Y., Lui, J., Richard‐Carpentier, G., Crocker, S. F., et al. (2021) · Journal of Molecular Diagnostics · doi:10.1016/j.jmoldx.2021.07.010 · Cited by 13

Next Generation Risk Markers in Preventive Cardio-oncology

Lamberg, M., Rossman, A., Bennett, A., Painter, S., Goodman, R. E., MacLeod, J., Maddula, R., Rayan, D., Doshi, K., Bick, A. G., et al. (2022) · Current Atherosclerosis Reports · doi:10.1007/s11883-022-01021-x · Cited by 11

The spectrum of somatic mutations in large granular lymphocyte leukemia, rheumatoid arthritis, and Felty's syndrome

Savola, P., Bhattacharya, D., & Huuhtanen, J. (2022) · Seminars in Hematology · doi:10.1053/j.seminhematol.2022.07.004 · Cited by 14

Hedgehog/GLI signaling in hematopoietic development and acute myeloid leukemia—From bench to bedside

Tesanovic, S., Krenn, P. W., & Aberger, F. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.944760 · Cited by 14

Biology of peripheral T cell lymphomas – Not otherwise specified: Is something finally happening?

Maura, F., Dodero, A., Carniti, C., & Bolli, N. (2016) · Pathogenesis · doi:10.1016/j.pathog.2016.02.002 · Cited by 13

Feasibility of BAALC gene expression for detection of minimal residual disease and risk stratification in normal karyotype acute myeloid leukaemia

Weber, S., Haferlach, T., Alpermann, T., Perglerová, K., Schnittger, S., Haferlach, C., & Kern, W. (2016) · British Journal of Haematology · doi:10.1111/bjh.14343 · Cited by 13

Monitoring therapy responses at the leukemic subclone level by ultra-deep amplicon resequencing in acute myeloid leukemia

Ojamies, P., Kontro, M., Edgren, H., Ellonen, P., Lagström, S., Almusa, H., Miettinen, T., Eldfors, S., Tamborero, D., Wennerberg, K., et al. (2016) · Leukemia · doi:10.1038/leu.2016.286 · Cited by 13

The Multi-kinase Inhibitor Debio 0617B Reduces Maintenance and Self-renewal of Primary Human AML CD34+ Stem/Progenitor Cells

Murone, M., Radpour, R., Attinger, A., Chessex, A. V., Huguenin, A.-L., Schürch, C., Banz, Y., Sengupta, S., Aguet, M., Rigotti, S., et al. (2017) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-16-0889 · Cited by 13

Cell-lineage level–targeted sequencing to identify acute myeloid leukemia with myelodysplasia-related changes

Yokoyama, K., Shimizu, E., Yokoyama, N., Nakamura, S., Kasajima, R., Ogawa, M., Takei, T., Ito, M., Kobayashi, A., Yamaguchi, R., et al. (2018) · Blood Advances · doi:10.1182/bloodadvances.2017010744 · Cited by 13

Molecular mechanisms for stemness maintenance of acute myeloid leukemia stem cells

Wang, J., Wang, P., Zhang, T., Gao, Z., Wang, J., Feng, M., Yin, R. L., & Zhang, H. (2019) · Blood Science · doi:10.1097/bs9.0000000000000020 · Cited by 15

Recent progress on targeting leukemia stem cells

Ma, X., Wei, L., Lei, Z., Chen, Y., Ding, Z., & Chen, Z. (2021) · Drug Discovery Today · doi:10.1016/j.drudis.2021.05.009 · Cited by 13

Cell Biology Meets Cell Metabolism: Energy Production Is Similar in Stem Cells and in Cancer Stem Cells in Brain and Bone Marrow

Noorden, C. J. F. V., Breznik, B., Novak, M., van Dijck, A. J., Tanan, S., Vittori, M., Bogataj, U., Bakker, N., Khoury, J. D., Molenaar, R. J., et al. (2021) · Journal of Histochemistry & Cytochemistry · doi:10.1369/00221554211054585 · Cited by 15

Cytosine modifications in myeloid malignancies

Meldi, K. M., & Figueroa, M. E. (2015) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2015.05.002 · Cited by 13

Single cell mutational profiling delineates clonal trajectories in myeloid malignanciesPreprint

Miles, L. A., Bowman, R. L., Merlinsky, T. R., Csete, I. S., Ooi, A. T., Durruthy-Durruthy, R., Bowman, M., Famulare, C. A., Patel, M. A., Méndez, P., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.02.07.938860 · Cited by 14

The Crossroads of Clonal Evolution, Differentiation Hierarchy, and Ontogeny in Leukemia Development

Sturgeon, C. M., Wagenblast, E., Izzo, F., & Papapetrou, E. P. (2024) · Blood Cancer Discovery · doi:10.1158/2643-3230.bcd-24-0235 · Cited by 12

Nucleophosmin1 and isocitrate dehydrogenase 1 and 2 as measurable residual disease markers in acute myeloid leukemia

Kövy, P., Őrfi, Z., Bors, A., Kozma, A., Gopcsa, L., Dolgos, J., Lovas, N., Harasztdombi, J., Lakatos, V., Király, Á., et al. (2021) · PLoS ONE · doi:10.1371/journal.pone.0253386 · Cited by 12

Leukemic progenitor compartment serves as a prognostic measure of cancer stemness in patients with acute myeloid leukemia

Boyd, A. L., Lu, J., Hollands, C. G., Alsostovar, L., Murali, S., Reid, J. C., Ye, W., Vandersluis, S., Johnson, P. M., Elrafie, A., et al. (2023) · Cell Reports Medicine · doi:10.1016/j.xcrm.2023.101108 · Cited by 12

Biomarkers in acute myeloid leukemia: From state of the art in risk classification to future challenges of RNA editing as disease predictor and therapy target

Quattrocchi, A., Cappelli, L. V., Simone, G. D., Marinis, E. D., Gentile, M., Gasperi, T., Pulsoni, A., Ascenzi, P., & Nervi, C. (2023) · Aspects of Molecular Medicine · doi:10.1016/j.amolm.2023.100023 · Cited by 12

BCL7A inhibits the progression and drug-resistance in acute myeloid leukemia

Li, T., Gao, R., Xu, K., Pan, P., Chen, C., Wang, D., Zhang, K., Qiao, J., & Gu, Y. (2024) · Drug Resistance Updates · doi:10.1016/j.drup.2024.101120 · Cited by 12

Learning the cellular origins across cancers using single-cell chromatin landscapes

Bairakdar, M. D., Lee, W., Giotti, B., Kumar, A., Štancl, P., Wagenblast, E., Hambardzumyan, D., Polak, P. P., Karlić, R., & Tsankov, A. M. (2025) · Nature Communications · doi:10.1038/s41467-025-63957-3 · Cited by 13

The potential role of liver stem cells in initiation of primary liver cancer

Zhi, X., Xiong, J., Zi, X., & Hu, Y. (2016) · Hepatology International · doi:10.1007/s12072-016-9730-9 · Cited by 12

Higher-Level Pathway Objectives of Epigenetic Therapy: A Solution to the p53 Problem in Cancer

Velcheti, V., Radivoyevitch, T., & Saunthararajah, Y. (2017) · American Society of Clinical Oncology Educational Book · doi:10.1200/edbk_174175 · Cited by 12

DNMT3Aco-mutation is required forFLT3-ITDas an adverse prognostic indicator in intermediate-risk cytogenetic group AML

Ma, J., Dunlap, J. B., Paliga, A., Traer, E. A., Press, R. D., Shen, L., & Fan, G. (2017) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.1080/10428194.2017.1397659 · Cited by 12

Management of AML Beyond “3 + 7” in 2019

Canaani, J. (2019) · Clinical Hematology International · doi:10.2991/chi.d.190316.001 · Cited by 12

Phase I Trial of Lithium and Tretinoin for Treatment of Relapsed and Refractory Non-promyelocytic Acute Myeloid Leukemia

Ueda, M., Stefan, T., Stetson, L. C., Ignatz-Hoover, J. J., Tomlinson, B. K., Creger, R. J., Cooper, B., Lazarus, H. M., Lima, M. J. G. D., Wald, D. N., et al. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.00327 · Cited by 12

Clonal Expansion of Stem/Progenitor Cells in Cancer, Fibrotic Diseases, and Atherosclerosis, and CD47 Protection of Pathogenic Cells

Majeti, R., Jamieson, C. H. M., Pang, W. W., Jaiswal, S., Leeper, N. J., Wernig, G., & Weissman, I. L. (2022) · Annual Review of Medicine · doi:10.1146/annurev-med-042420-104436 · Cited by 12

Preferential Self-interaction of DNA Methyltransferase DNMT3A Subunits Containing the R882H Cancer Mutation Leads to Dominant Changes of Flanking Sequence Preferences

Mack, A., Emperle, M., Schnee, P., Adam, S., Pleiss, J., Bashtrykov, P., & Jeltsch, A. (2022) · Journal of Molecular Biology · doi:10.1016/j.jmb.2022.167482 · Cited by 12

Ribosome changes reprogram translation for chemosurvival in G0 leukemic cells

Datta, C., Truesdell, S. S., Wu, K. Q., Bukhari, S. I. A., Ngue, H., Buchanan, B., Tonquèze, O. L., Lee, S., Kollu, S., Granovetter, M. A., et al. (2022) · Science Advances · doi:10.1126/sciadv.abo1304 · Cited by 15

Persistent IDH mutations are not associated with increased relapse or death in patients with IDH-mutated acute myeloid leukemia undergoing allogeneic hematopoietic cell transplant with post-transplant cyclophosphamide

Ravindra, N., Dillon, L. W., Gui, G., Smith, M., Gondek, L. P., Jones, R. J., Corner, A., Hourigan, C. S., & Ambinder, A. J. (2024) · Bone Marrow Transplantation · doi:10.1038/s41409-023-02189-9 · Cited by 12

Back to Biology: New Insights on Inheritance in Myeloproliferative Disorders

Braunstein, E. M., & Moliterno, A. R. (2014) · Current Hematologic Malignancy Reports · doi:10.1007/s11899-014-0232-3 · Cited by 12

Overview: Cancer Stem Cell and Tumor Environment

Minami, Y. (2015) · Oncology · doi:10.1159/000431060 · Cited by 12

Epigenetic perturbations in aging stem cells

Krauss, S. R., & de Haan, G. (2016) · Mammalian Genome · doi:10.1007/s00335-016-9645-8 · Cited by 14

Canonical WNT Signaling Pathway is Altered in Mesenchymal Stromal Cells From Acute Myeloid Leukemia Patients And Is Implicated in BMP4 Down-Regulation

Azevedo, P., Oliveira, N., Corrêa, S., Castelo-Branco, M. T. L., Abdelhay, E. S. F. W., & Binato, R. (2019) · Translational Oncology · doi:10.1016/j.tranon.2019.01.003 · Cited by 12

Tumor heterogeneity of acute myeloid leukemia: insights from single-cell sequencing

Chen, A., Hu, S., & Wang, Q. (2019) · Blood Science · doi:10.1097/bs9.0000000000000015 · Cited by 12

Transplantation in Acute Myeloid Leukemia

Zuckerman, T., & Rowe, J. M. (2014) · Hematology/Oncology Clinics of North America · doi:10.1016/j.hoc.2014.08.016 · Cited by 12

Mutations in epigenetic modifiers in acute myeloid leukemia and their clinical utility

Hou, H., & Tien, H. (2016) · Expert Review of Hematology · doi:10.1586/17474086.2016.1144469 · Cited by 13

Somatic mutations in murine models of leukemia and lymphoma: Disease specificity and clinical relevance

Goldberg, L., Gough, S. M., Lee, F., Dang, C., Walker, R. L., Zhu, Y. J., Bilke, S., Pineda, M. A., Onozawa, M., Chung, Y. J., et al. (2017) · Genes Chromosomes and Cancer · doi:10.1002/gcc.22451 · Cited by 12

The impact of DNMT3A variant allele frequency and two different comutations on patients with de novo cytogenetically normal acute myeloid leukemia

Chen, X., Tian, C., Hao, Z., Pan, L., Hong, M., Wei, W., Muyey, D. M., Wang, H., & Chen, X. (2023) · Cancer Medicine · doi:10.1002/cam4.5764 · Cited by 11

Clinical and Therapeutic Implications of Clonal Hematopoiesis

Petrone, G. E. M., Turker, I., Natarajan, P., & Bolton, K. L. (2024) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev-genom-120722-100409 · Cited by 11

Persistent postremission clonal hematopoiesis shapes the relapse trajectories of acute myeloid leukemia

Chow, R. D.-W., Velu, P., Deihimi, S., Belman, J., Youn, A., Shah, N., Luger, S. M., Carroll, M. P., Morrissette, J. J. D., & Bowman, R. L. (2025) · Blood Advances · doi:10.1182/bloodadvances.2024015149 · Cited by 12

Concise Review: Induced Pluripotent Stem Cells as New Model Systems in Oncology

Laplane, L., Beke, A., Vainchenker, W., & Solary, É. (2015) · Stem Cells · doi:10.1002/stem.2099 · Cited by 11

Is lineage decision-making restricted during tumoral reprograming of haematopoietic stem cells?

Brown, G., & Sánchez-Garcı́a, I. (2015) · Oncotarget · doi:10.18632/oncotarget.6145 · Cited by 12

Leukemia Stem Cells in the Pathogenesis, Progression, and Treatment of Acute Myeloid Leukemia

Joshi, K., Zhang, L., Breslin, P., & Zhang, J. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-981-13-7342-8_5 · Cited by 14

Atypical CML- the role of morphology and precision genomics

Lasho, T. L. (2019) · Best Practice & Research Clinical Haematology · doi:10.1016/j.beha.2019.101133 · Cited by 11

Oncogene-Induced Reprogramming in Acute Lymphoblastic Leukemia: Towards Targeted Therapy of Leukemia-Initiating Cells

Fregona, V., Bayet, M., & Gerby, B. (2021) · Cancers · doi:10.3390/cancers13215511 · Cited by 15

Introducing minimal residual disease in acute myeloid leukemia

Ofran, Y., & Rowe, J. M. (2015) · Current Opinion in Hematology · doi:10.1097/moh.0000000000000113 · Cited by 11

Reduced DNA methylation and hydroxymethylation in patients with systemic mastocytosis

Leoni, C., Montagner, S., Dehò, L., D’Antuono, R., MATTEIS, G. D., Marzano, A. V., Merante, S., Orlandi, E. M., Zanotti, R., & Monticelli, S. (2015) · European Journal Of Haematology · doi:10.1111/ejh.12537 · Cited by 11

Cancer Stem Cells as a Target Population for Drug Discovery

Bouvard, C., Barefield, C., & Zhu, S. (2014) · Future Medicinal Chemistry · doi:10.4155/fmc.14.106 · Cited by 10

Impact of genomics in the clinical management of patients with cytogenetically normal acute myeloid leukemia

Falini, B., & Martelli, M. P. (2015) · Best Practice & Research Clinical Haematology · doi:10.1016/j.beha.2015.10.005 · Cited by 11

Clinicopathologic Effect of DNMT3A Mutation in Adult T-Cell Acute Lymphoblastic Leukemia

Aref, S., Menshawy, N. E., El-Ghonemy, M. S., Abouzeid, T., & ElBaiomy, M. A. (2015) · Clinical Lymphoma Myeloma & Leukemia · doi:10.1016/j.clml.2015.11.003 · Cited by 12

Altered neutrophil immunophenotypes in childhood B-cell precursor acute lymphoblastic leukemia

Oliveira, E., Bacelar, T. D. S., Ciudad, J., Ribeiro, M. C. M., Garcia, D. R. N., Sędek, Ł., Maia, S. F., Aranha, D., Machado, I. C., Ikeda, A., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.8369 · Cited by 11

Novel Mitochondrial Mechanisms of Cytarabine Resistance in Primary AML Cells

Schimmer, A. D. (2017) · Cancer Discovery · doi:10.1158/2159-8290.cd-17-0476 · Cited by 12

Measurement of Residual Disease in Acute Myeloid Leukemia

Vedula, R. S., & Lindsley, R. C. (2017) · Current Hematologic Malignancy Reports · doi:10.1007/s11899-017-0428-4 · Cited by 11

Loss of DNA methyltransferase activity in primed human ES cells triggers increased cell-cell variability and transcriptional repression

Tsankov, A. M., Wadsworth, M. H., Akopian, V., Charlton, J., Allon, S. J., Arczewska, A., Mead, B. E., Drake, R. S., Smith, Z. D., Mikkelsen, T. S., et al. (2019) · Development · doi:10.1242/dev.174722 · Cited by 10

Mutations predictive of hyperactive Ras signaling correlate with inferior survival across high-risk pediatric acute leukemia

Ney, G. M., Anderson, B., Bender, J. D., Kumar‐Sinha, C., Wu, Y., Vats, P., Cieslik, M. P., Robinson, D. R., Li, Q., Chinnaiyan, A. M., et al. (2020) · Translational Pediatrics · doi:10.21037/tp.2019.12.03 · Cited by 9

Modeling low-dose radiation-induced acute myeloid leukemia in male CBA/H mice

Stouten, S., Lunel, S. M. V., Finnon, R., Badie, C., & Dekkers, F. (2020) · Radiation and Environmental Biophysics · doi:10.1007/s00411-020-00880-9 · Cited by 14

Mayo Clinic experience with 1123 adults with acute myeloid leukemia

Begna, K. H., Ali, W. R., Gangat, N., Elliott, M. A., Al‐Kali, A., Litzow, M. R., Hook, C. C., Wolanskyj, A. P., Hogan, W. J., Patnaik, M. M., et al. (2021) · Blood Cancer Journal · doi:10.1038/s41408-021-00435-1 · Cited by 11

Pseudo-mutant P53 is a unique phenotype of DNMT3A-mutated pre-leukemia

Tuval, A., Brilon, Y., Azogy, H., Moskovitz, Y., Biezuner, T., Leshkowitz, D., Salame, T. M., Minden, M. D., Tal, P., Rotter, V., et al. (2022) · Haematologica · doi:10.3324/haematol.2021.280329 · Cited by 12

Targeted Therapy of FLT3 in Treatment of AML—Current Status and Future Directions

Engen, C., Wergeland, L., Skavland, J., & Gjertsen, B. T. (2014) · Journal of Clinical Medicine · doi:10.3390/jcm3041466 · Cited by 11

Charting single-cell lineages with synthetic and natural barcodes

Rodriguez-Fraticelli, A., & Parreno, V. (2026) · Nature Reviews Genetics · doi:10.1038/s41576-026-00943-5 · Cited by 11

Symptomatic Heart Failure and Clonal Hematopoiesis–Related Mutations in Patients With Acute Myeloid Leukemia

Kang, Y. M., Lefebvre, B., Martí-Pàmies, Í., Gill, S. I., Doucette, A. G., Denduluri, S., Smith, A. M., McCurdy, S. R., Luger, S. M., Carver, J. R., et al. (2024) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2024.06.033 · Cited by 10

DNA methylation drives hematopoietic stem cell aging phenotypes after proliferative stress

Yanai, H., McNeely, T. L., Ayyar, S., Leone, M., Zong, L., Park, B., & Beerman, I. (2024) · GeroScience · doi:10.1007/s11357-024-01360-4 · Cited by 14

Clonal hematopoiesis landscape in frequent blood donors

Karpova, D., Encabo, H. H., Donato, E., Calderazzo, S., Scherer, M., Llorian, M., Leppä, A., Würth, R., Stelmach, P., Papazoglou, D., et al. (2025) · Blood · doi:10.1182/blood.2024027999 · Cited by 15

Persistence of leukaemic ancestors

Potter, N. E., & Greaves, M. F. (2014) · Nature · doi:10.1038/nature13056 · Cited by 7

DNMT3a Mutations Define a Pre-Leukemic Stem Cell Reservoir In Human Acute Myeloid Leukemia

Shlush, L. I., Zandi, S., Mitchell, A., Chen, W. C., Jessica, M., Doedens, M., Medeiros, J. J. F., Marke, R., John, M. J., Hudson, T. J., et al. (2013) · Blood · doi:10.1182/blood.v122.21.487.487 · Cited by 4

Abstract 3303: Clonal evolution of pre-leukemic hematopoietic stem cells precedes human acute myeloid leukemia

Jan, M., Snyder, T. M., Corces, M. R., Weissman, I. L., Quake, S. R., & Majeti, R. (2012) · Cancer Research · doi:10.1158/1538-7445.am2012-3303

Clonal evolution of pre-leukemic hematopoietic stem cells precedes human acute myeloid leukemia

Majeti, R. (2014) · Best Practice & Research Clinical Haematology · doi:10.1016/j.beha.2014.10.003 · Cited by 32

Abstract SY35-01: Clonal evolution of pre-leukemic hematopoietic stem cells precedes human acute myeloid leukemia

Jan, M., Snyder, T. M., Corces, M. R., Quake, S. R., Weissman, I. L., & Majeti, R. (2012) · Cancer Research · doi:10.1158/1538-7445.am2012-sy35-01 · Cited by 2