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mTORC1 controls the adaptive transition of quiescent stem cells from G0 to GAlert
Open accessAbstract
A unique property of many adult stem cells is their ability to exist in a non-cycling, quiescent state. Although quiescence serves an essential role in preserving stem cell function until the stem cell is needed in tissue homeostasis or repair, defects in quiescence can lead to an impairment in tissue function. The extent to which stem cells can regulate quiescence is unknown. Here we show that the stem cell quiescent state is composed of two distinct functional phases, G0 and an 'alert' phase we term G(Alert). Stem cells actively and reversibly transition between these phases in response to injury-induced systemic signals. Using genetic mouse models specific to muscle stem cells (or satellite cells), we show that mTORC1 activity is necessary and sufficient for the transition of satellite cells from G0 into G(Alert) and that signalling through the HGF receptor cMet is also necessary. We also identify G0-to-G(Alert) transitions in several populations of quiescent stem cells. Quiescent stem cells that transition into G(Alert) possess enhanced tissue regenerative function. We propose that the transition of quiescent stem cells into G(Alert) functions as an 'alerting' mechanism, an adaptive response that positions stem cells to respond rapidly under conditions of injury and stress, priming them for cell cycle entry.
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“inflammatory initiation of a cell cycle–primed Galert state in HSCs and other cells requires activation of mammalian target of rapamycin (Rodgers et al., 2014).”
From PU.1 enforces quiescence and limits hematopoietic stem cell expansion during inflammatory stress (2021) · cites this paper as Rodgers et al., 2014
Experimental — accuracy not yet measuredIn the citing paper
“Likewise, ‘priming’ of activation by systemic signaling factors has been reported to improve regeneration (Rodgers et al., 2014, 2017).”
From Aging induces aberrant state transition kinetics in murine muscle stem cells (2020) · cites this paper as Rodgers et al., 2014
In the citing paper
“Across all clusters, there were no distinct cell-cycle states observed, consistent with reports of the first division occurring ≥24 hours after our 18 h time point (Gilbert et al., 2010; Rodgers et al., 2014) (Fig. S2D).”
From Aging induces aberrant state transition kinetics in murine muscle stem cells (2020) · cites this paper as Rodgers et al., 2014
In the citing paper
“For instance, although we do not observe bistable transcriptional states between the most-quiescent and most-activated cells in our experiments, stable intermediary activation states might exist in vivo (Rodgers et al., 2014).”
From Aging induces aberrant state transition kinetics in murine muscle stem cells (2020) · cites this paper as Rodgers et al., 2014
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Cites
Adjusting batch effects in microarray expression data using empirical Bayes methods
Johnson, W. E., Li, C., & Rabinovic, A. (2007) · Biostatistics · doi:10.1093/biostatistics/kxj037 · Cited by 8,658
mTOR Signaling in Growth Control and Disease
Laplante, M., & Sabatini, D. M. (2012) · Cell · doi:10.1016/j.cell.2012.03.017 · Cited by 8,509
KEGG for integration and interpretation of large-scale molecular data sets
Kanehisa, M., Goto, S., Sato, Y., Furumichi, M., & Tanabe, M. (2012) · Nucleic Acids Research · doi:10.1093/nar/gkr988 · Cited by 4,848
Cellular and Molecular Regulation of Muscle Regeneration
CHARGÉ, S. B. P., & Rudnicki, M. A. (2004) · Physiological Reviews · doi:10.1152/physrev.00019.2003 · Cited by 2,691
Pax7 Is Required for the Specification of Myogenic Satellite Cells
Seale, P., Sabourin, L. A., Girgis-Gabardo, A., Mansouri, A., Gruß, P., & Rudnicki, M. A. (2000) · Cell · doi:10.1016/s0092-8674(00)00066-0 · Cited by 2,345
G 1 Events and Regulation of Cell Proliferation
Pardee, A. B. (1989) · Science · doi:10.1126/science.2683075 · Cited by 2,182
Wilson, A., Laurenti, E., Oser, G., van der Wath, R. C., Blanco-Bose, W., Jaworski, M., Offner, S., Dunant, C. F., Eshkind, L., Bockamp, E., et al. (2008) · Cell · doi:10.1016/j.cell.2008.10.048 · Cited by 1,908
Muscle injury activates resident fibro/adipogenic progenitors that facilitate myogenesis
Joe, A. W. B., Yi, L., Natarajan, A., Le Grand, F., So, L., Wang, J., Rudnicki, M. A., & Rossi, F. M. V. (2010) · Nature Cell Biology · doi:10.1038/ncb2015 · Cited by 1,690
Rainer Breitling, A., Armengaud, P., Anna Amtmann, A., & Herzyk, P. (2004) · FEBS Letters · doi:10.1016/j.febslet.2004.07.055 · Cited by 1,478
Uezumi, A., Fukada, S., Yamamoto, N., Takeda, S., & Tsuchida, K. (2010) · Nature Cell Biology · doi:10.1038/ncb2014 · Cited by 1,315
Flagged first, then by citations
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Items 201–300 of 774
Midbrain tectal stem cells display diverse regenerative capacities in zebrafish
Lindsey, B. W., Aitken, G., Tang, J., Khabooshan, M. A., Douek, A. M., Vandestadt, C., & Kaslin, J. (2019) · Scientific Reports · doi:10.1038/s41598-019-40734-z · Cited by 48
Sestrin is a key regulator of stem cell function and lifespan in response to dietary amino acids
Lu, J., Temp, U., Müller-Hartmann, A., Eßer, J., Grönke, S., & Partridge, L. (2020) · Nature Aging · doi:10.1038/s43587-020-00001-7 · Cited by 46
The mechanosensitive ion channel PIEZO1 promotes satellite cell function in muscle regeneration
Hirano, K., Tsuchiya, M., Shiomi, A., Takabayashi, S., Suzuki, M., Ishikawa, Y., Kawano, Y., Takabayashi, Y., Nishikawa, K., Nagao, K., et al. (2022) · Life Science Alliance · doi:10.26508/lsa.202201783 · Cited by 49
Thomas, P. D., & Kahn, M. (2016) · Cell Biology and Toxicology · doi:10.1007/s10565-016-9318-0 · Cited by 48
Bridges, C. R., Tan, M. C., Premarathne, S., Nanayakkara, D. M., Bellette, B., Zencak, D., Domingo, D., Gécz, J., Murtaza, M., Jolly, L. A., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-00149-0 · Cited by 47
CCRK is a novel signalling hub exploitable in cancer immunotherapy
Mok, M. T. S., Zhou, J., Tang, W., Zeng, X., Oliver, A. W., Ward, S. E., & Cheng, A. S. L. (2018) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2018.01.008 · Cited by 48
Magnusson, J. P., & Frisén, J. (2016) · Development · doi:10.1242/dev.133975 · Cited by 46
p110α of PI3K is necessary and sufficient for quiescence exit in adult muscle satellite cells
Wang, G., Zhu, H., Situ, C., Han, L., Yu, Y., Cheung, T. H., Liu, K., & Wu, Z. (2018) · The EMBO Journal · doi:10.15252/embj.201798239 · Cited by 49
Enhancer selection dictates gene expression responses in remote organs during tissue regeneration
Sun, F., Ou, J., Shoffner, A. R., Luan, Y., Yang, H., Song, L., Safi, A., Cao, J., Yue, F., Crawford, G. E., et al. (2022) · Nature Cell Biology · doi:10.1038/s41556-022-00906-y · Cited by 49
The effect of extracellular acidosis on the behaviour of mesenchymal stem cells in vitro
Istituto Ortopedico Rizzoli, O. P. A. R. M. U., Massa, A., Perut, F., Chano, T., Woloszyk, A., Mitsiadis, T. A., Avnet, S., & Baldini, N. (2017) · European Cells and Materials · doi:10.22203/ecm.v033a19 · Cited by 45
Masamoto, Y., Arai, S., Sato, T., Kubota, N., Takamoto, I., Kadowaki, T., & Kurokawa, M. (2017) · Stem Cells · doi:10.1002/stem.2640 · Cited by 49
The Skeletal Muscle Emerges as a New Disease Target in Amyotrophic Lateral Sclerosis
Pikatza‐Menoio, O., Elicegui, A., Bengoetxea, X., Naldaiz‐Gastesi, N., de Munaín, A. L., Gereñu, G., Gil-Bea, F. J., & Alonso‐Martín, S. (2021) · Journal of Personalized Medicine · doi:10.3390/jpm11070671 · Cited by 50
He, L., Ding, Y., Zhao, Y. F., So, K. K. H., Peng, X. L., Li, Y., Yuan, J., He, Z., Chen, X., Sun, H., et al. (2021) · Stem Cell Reports · doi:10.1016/j.stemcr.2021.08.011 · Cited by 45
Hormones, Metabolism and the Benefits of Exercise
(2017) · Research and Perspectives in Endocrine Interactions · doi:10.1007/978-3-319-72790-5 · Cited by 44
Decoding the stem cell quiescence cycle – lessons from yeast for regenerative biology
Dhawan, J., & Laxman, S. (2015) · Journal of Cell Science · doi:10.1242/jcs.177758 · Cited by 45
Bowers, S., Kemp, S. S., Aguera, K. N., Koller, G. M., Forgy, J. C., & Davis, G. E. (2020) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.120.314517 · Cited by 44
Neural Stem Cell Activation and the Role of Protein Synthesis
Baser, A., Skabkin, M. A., & Martín-Villalba, A. (2017) · Brain Plasticity · doi:10.3233/bpl-160038 · Cited by 43
TNNT1 facilitates proliferation of breast cancer cells by promoting G1/S phase transition
Shi, Y., Zhao, Y., Zhang, Y., AiErken, N., Shao, N., Ye, R., Lin, Y., & Wang, S. (2018) · Life Sciences · doi:10.1016/j.lfs.2018.07.034 · Cited by 42
Differentiation reveals latent features of aging and an energy barrier in murine myogenesis
Kimmel, J. C., Yi, N., Roy, M., Hendrickson, D. G., & Kelley, D. R. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109046 · Cited by 42
Delaney, S. P., Julian, L. M., & Stanford, W. L. (2014) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2014.00069 · Cited by 40
Mikkelsen, U. R., Dideriksen, K., Andersen, M., Boesen, A., Malmgaard-Clausen, N. M., Sørensen, I. J., Schjerling, P., Kjær, M., & Holm, L. (2015) · Arthritis Research & Therapy · doi:10.1186/s13075-015-0758-3 · Cited by 45
Beyond Genetics: The Role of Metabolism in Photoreceptor Survival, Development and Repair
Hanna, J., David, L. A., Touahri, Y., Fleming, T., Screaton, R. A., & Schuurmans, C. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.887764 · Cited by 45
Lysosomes at the Crossroads of Cell Metabolism, Cell Cycle, and Stemness
Nowosad, A., & Besson, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23042290 · Cited by 39
Endo, T. (2023) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2023.09.048 · Cited by 44
Retinal cell death dependent reactive proliferative gliosis in the mouse retina
Pasha, S. P. B. S., Münch, R., Schäfer, P., Oertel, P., Sykes, A. M., Zhu, Y., & Karl, M. (2017) · Scientific Reports · doi:10.1038/s41598-017-09743-8 · Cited by 40
Gulaia, V. S., Kumeiko, V. V., Shved, N. A., Cicinskas, E., Александрович, Р. С., Ruzov, A. S., & Kagansky, A. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00388 · Cited by 39
Bohin, N., McGowan, K., Keeley, T. M., Carlson, E. A., Yan, K. S., & Samuelson, L. C. (2020) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2020.05.013 · Cited by 43
MiRNAs and Muscle Regeneration: Therapeutic Targets in Duchenne Muscular Dystrophy
Aránega, A. E., Lozano-Velasco, E., Rodríguez-Outeiriño, L., de Acuña, F. R., Franco, D., & Hernández‐Torres, F. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22084236 · Cited by 44
Jensen, J. B., Dollerup, O. L., Møller, A. B., Billeskov, T. B., Dalbram, E., Chubanava, S., Damgaard, M. V., Dellinger, R. W., Trošt, K., Moritz, T., et al. (2022) · JCI Insight · doi:10.1172/jci.insight.158314 · Cited by 39
Lees-Shepard, J. B., Stoessel, S. J., Chandler, J., Bouchard, K., Bento, P., Apuzzo, L. N., Devarakonda, P. M., Hunter, J. W., & Goldhamer, D. J. (2022) · Journal of Clinical Investigation · doi:10.1172/jci153795 · Cited by 41
mTOR pathway occupies a central role in the emergence of latent cancer cells
Aleksandrova, K. V., Vorobev, M. L., & Suvorova, I. I. (2024) · Cell Death and Disease · doi:10.1038/s41419-024-06547-3 · Cited by 39
Protein Supplementation Does Not Affect Myogenic Adaptations to Resistance Training
Reidy, P. T., Fry, C. S., Igbinigie, S. N., Deer, R., Jennings, K., Cope, M. B., Mukherjea, R., Volpi, E., & Rasmussen, B. B. (2017) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000001224 · Cited by 44
Alternative Polyadenylation in Stem Cell Self-Renewal and Differentiation
Sommerkamp, P., Cabezas‐Wallscheid, N., & Trumpp, A. (2021) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2021.04.006 · Cited by 40
Metformin delays satellite cell activation and maintains quiescence
Pavlidou, T., Marinkovic, M., Rosina, M., Fuoco, C., Vumbaca, S., Gargioli, C., Castagnoli, L., & Cesareni, G. (2019) · Stem Cells International · doi:10.1155/2019/5980465 · Cited by 38
Dunaway, S., Rothaus, A., Zhang, Y., Kadekaro, A. L., Andl, T., & Andl, C. D. (2019) · International Journal of Oral Science · doi:10.1038/s41368-019-0061-2 · Cited by 40
Hallmarks of cancer and hallmarks of aging
Blagosklonny, M. V. (2022) · Aging · doi:10.18632/aging.204082 · Cited by 43
It is not all about regeneration: Planarians striking power to stand starvation
Felix, D. A., Gutiérrez‐Gutiérrez, Ó., Espada, L., Thems, A., & González‐Estévez, C. (2018) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2018.04.010 · Cited by 43
Anti-aging: senolytics or gerostatics (unconventional view)
Blagosklonny, M. V. (2021) · Oncotarget · doi:10.18632/oncotarget.28049 · Cited by 38
HES1 protein oscillations are necessary for neural stem cells to exit from quiescence
Marinopoulou, E., Biga, V., Sabherwal, N., Miller, A., Desai, J., Adamson, A. D., & Papalopulu, N. (2021) · iScience · doi:10.1016/j.isci.2021.103198 · Cited by 33
Chan, K. S. (2015) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-15-0183 · Cited by 39
Zhang, S., Yang, F., Huang, Y., He, L., Li, Y., Wan, Y. C. E., Ding, Y., Chan, K. M., Xie, T., Sun, H., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-40465-w · Cited by 36
Yeast quiescence exit swiftness is influenced by cell volume and chronological age
Laporte, D., Jimenez, L., Gouleme, L., & Sagot, I. (2018) · Microbial Cell · doi:10.15698/mic2018.02.615 · Cited by 37
Akt1 deficiency diminishes skeletal muscle hypertrophy by reducing satellite cell proliferation
Moriya, N., & Miyazaki, M. (2018) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00336.2017 · Cited by 39
Role of Metabolic Stress and Exercise in Regulating Fibro/Adipogenic Progenitors
Collao, N., Farup, J., & Lisio, M. D. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00009 · Cited by 39
Wu, C., Satomi, Y., & Walsh, K. X. (2017) · BMC Genomics · doi:10.1186/s12864-017-3548-2 · Cited by 40
Non-equivalence of nuclear import among nuclei in multinucleated skeletal muscle cells
Cutler, A. A., Jackson, J., Corbett, A. H., & Pavlath, G. K. (2018) · Journal of Cell Science · doi:10.1242/jcs.207670 · Cited by 36
Activation of PASK by mTORC1 is required for the onset of the terminal differentiation program
Kikani, C. K., Wu, X., Fogarty, S., Kang, S. A., Dephoure, N., Gygi, S. P., Sabatini, D. M., & Rutter, J. P. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1804013116 · Cited by 35
Donega, V., Burm, S. M., van Strien, M. E., van Bodegraven, E. J., Paliukhovich, I., Geut, H., van de Berg, W. D. J., Li, K. W., Smit, A. B., Başak, O., et al. (2019) · Acta Neuropathologica Communications · doi:10.1186/s40478-019-0736-0 · Cited by 36
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Collins, B. C., & Kardon, G. (2021) · Development · doi:10.1242/dev.199861 · Cited by 40
Plasticity of the Muscle Stem Cell Microenvironment
Dinulović, I., Furrer, R., & Handschin, C. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-69194-7_8 · Cited by 37
GILZ-dependent modulation of mTORC1 regulates spermatogonial maintenance
La, H. M., Chan, A.-L., Legrand, J. M. D., Rossello, F. J., Gangemi, C. G., Papa, A., Cheng, Q., Morand, E. F., & Hobbs, R. M. (2018) · Development · doi:10.1242/dev.165324 · Cited by 36
Millward, D. J. (2021) · Nutrients · doi:10.3390/nu13030729 · Cited by 44
Mater, D. V., Añó, L., Blum, J. M., Webster, M. T., Huang, W., Williams, N. T., Ma, Y., Cardona, D. M., Fan, C., & Kirsch, D. G. (2014) · Cancer Research · doi:10.1158/0008-5472.can-14-2527 · Cited by 35
Protein Availability and Satellite Cell Dynamics in Skeletal Muscle
Shamim, B., Hawley, J. A., & CAMERA, D. M. (2018) · Sports Medicine · doi:10.1007/s40279-018-0883-7 · Cited by 42
Kim, K. M., Yoo, G. D., Heo, W., Oh, H. T., Park, J., Shin, S., Do, Y., Jeong, M. G., Hwang, E. S., & Hong, J. (2023) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.13348 · Cited by 36
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Alhaddad, L., Chuprov‐Netochin, R. N., Pustovalova, M. V., Osipov, A. N., & Leonov, S. V. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24021228 · Cited by 34
Psat1-generated α-ketoglutarate and glutamine promote muscle stem cell activation and regenerationPreprint
Ciuffoli, V., Feng, X., Jiang, K., Acevedo-Luna, N., Ko, K. D., Wang, A. H. J., Riparini, G., Khateb, M., Glancy, B. C., Dell’Orso, S., et al. (2024) · Genes & Development · doi:10.1101/gad.351428.123 · Cited by 38
Cellular enlargement - A new hallmark of aging?
Davies, D., van den Handel, K., Bharadwaj, S., & Lengefeld, J. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.1036602 · Cited by 32
Pericyte response to contraction mode-specific resistance exercise training in human skeletal muscle
Farup, J., Lisio, M. D., Rahbek, S. K., Bjerre, J., Vendelbo, M. H., Boppart, M. D., & Vissing, K. (2015) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01108.2014 · Cited by 37
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Borok, M. J., Didier, N., Gattazzo, F., Ozturk, T., Corneau, A., Rouard, H., & Relaix, F. (2021) · Cells · doi:10.3390/cells10040744 · Cited by 33
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Zhang, Q., Han, W., Wu, R., Deng, S., Meng, J., Yang, Y., Li, L., Sun, M., Ai, H., Chen, Y., et al. (2024) · Cell Discovery · doi:10.1038/s41421-024-00712-w · Cited by 36
Parallels between wound healing, epimorphic regeneration and solid tumors
Wong, A. Y. L., & Whited, J. L. (2020) · Development · doi:10.1242/dev.181636 · Cited by 31
Fukada, S., & Ito, N. (2021) · Experimental Cell Research · doi:10.1016/j.yexcr.2021.112907 · Cited by 32
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La, H. M., Liao, J., Legrand, J. M. D., Rossello, F. J., Chan, A.-L., Vaghjiani, V., Cain, J. E., Papa, A., Lee, T., & Hobbs, R. M. (2022) · Nature Communications · doi:10.1038/s41467-022-30130-z · Cited by 34
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Kotsaris, G., Qazi, T. H., Bucher, C. H., Zahid, H., Pöhle‐Kronawitter, S., Ugorets, V., Jarassier, W., Börno, S. T., Timmermann, B., Giesecke‐Thiel, C., et al. (2023) · npj Regenerative Medicine · doi:10.1038/s41536-023-00291-6 · Cited by 31
Wang, X., Seekaew, P., Gao, X., & Chen, J. (2016) · eneuro · doi:10.1523/eneuro.0162-16.2016 · Cited by 31
Cochard, L. M., Levros, L.-C., Joppé, S. E., Pratesi, F., Aumont, A., & Fernandes, K. J. L. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.621076 · Cited by 31
Sugamori, Y., Mise‐Omata, S., Maeda, C., Aoki, S., Tabata, Y., Murali, R., Yasuda, H., Udagawa, N., Suzuki, H., Honma, M., et al. (2016) · BioEssays · doi:10.1002/bies.201600104 · Cited by 32
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Gidfar, S., Milani, F. Y., Milani, B. Y., Shen, X., Eslani, M., Putra, I., Huvard, M. J., Sagha, H. M., & Djalilian, A. R. (2017) · Scientific Reports · doi:10.1038/srep40308 · Cited by 31
Nieto-González, J. L., Gómez‐Sánchez, L., Mavillard, F., Linares‐Clemente, P., Rivero, M., Valenzuela-Villatoro, M., Muñoz‐Bravo, J. L., Pardal, R., & Fernández‐Chacón, R. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1817183116 · Cited by 31
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Price, F. D., Matyas, M. N., Gehrke, A. R., Chen, W., Wolin, E., Holton, K. M., Gibbs, R. M., Lee, A. E., Singu, P. S., Sakakeeny, J. S., et al. (2024) · Nature Biotechnology · doi:10.1038/s41587-024-02344-7 · Cited by 29
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Lund-Ricard, Y., Cormier, P., Morales, J., & Boutet, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21082718 · Cited by 30
Robinson, D. C. L., Ritso, M., Nelson, G. M., Mokhtari, Z., Nakka, K. K., Bandukwala, H., Goldman, S. R., Park, P. J., Mounier, R., Chazaud, B., et al. (2020) · Developmental Cell · doi:10.1016/j.devcel.2021.02.025 · Cited by 29
Firearms-related skeletal muscle trauma: pathophysiology and novel approaches for regeneration
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Thomas, A. C. Q., Brown, A., Hatt, A. A., Manta, K., Costa‐Parke, A., Kamal, M. J., Joanisse, S., McGlory, C., Phillips, S. M., Kumbhare, D. A., et al. (2022) · The FASEB Journal · doi:10.1096/fj.202200398rr · Cited by 29
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Sala, L., Kumar, M., Prajapat, M. K., Chandrasekhar, S., Cosby, R. L., Rocca, G. L., Macfarlan, T. S., Awasthi, P., Chari, R., Kruhlak, M. J., et al. (2023) · Nature Structural & Molecular Biology · doi:10.1038/s41594-023-01151-z · Cited by 30
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Artoni, F., Kreipke, R. E., Palmeira, O., Dixon, C., Goldberg, Z. H., & Ruohola‐Baker, H. (2017) · eLife · doi:10.7554/elife.27842 · Cited by 29
Chang, C., Liu, F., Militi, S., Hester, S. S., Nibhani, R., Deng, S., Dunford, J. E., Rendek, A., Soonawalla, Z. F., Fischer, R., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-47680-z · Cited by 31
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Cho, C. J., Brown, J. W., & Mills, J. C. (2024) · The EMBO Journal · doi:10.1038/s44318-024-00099-0 · Cited by 31
Fromer, M. W., Chang, S., Hagaman, A. L. R., Koko, K. R., Nolan, R. S., Zhang, P., Brown, S. A., Carpenter, J. P., & Caputo, F. J. (2017) · Journal of Vascular Surgery · doi:10.1016/j.jvs.2017.05.094 · Cited by 29
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Fu, X., He, Q., Tao, Y., Wang, M., Wang, W., Wang, Y., Yu, Q. C., Zhang, F., Zhang, X., Chen, Y., et al. (2021) · Science China Life Sciences · doi:10.1007/s11427-021-2007-8 · Cited by 30
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Fu, X., Zhuang, C., & Hu, P. (2022) · Cell Regeneration · doi:10.1186/s13619-022-00142-7 · Cited by 32
Oderberg, I. M., & Goessling, W. (2023) · JCI Insight · doi:10.1172/jci.insight.163929 · Cited by 30
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Murley, A., Popovici, A. C., Hu, X., Lund, A., Wickham, K., Durieux, J., Joe, L. K., Koronyo, E., Zhang, H., Genuth, N. R., et al. (2025) · Cell · doi:10.1016/j.cell.2025.03.009 · Cited by 31
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Coppin, E., Florentin, J., Vasamsetti, S. B., Arunkumar, A., Sembrat, J., Rojas, M. M., & Dutta, P. (2018) · Immunology and Cell Biology · doi:10.1111/imcb.12035 · Cited by 28
Zhou, S., Han, L., Weng, M., Zhu, H., Heng, Y., Wang, G., Shen, Z., Chen, X., Fu, X., Zhang, M., et al. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2021093118 · Cited by 33
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Balnis, J., Drake, L. A., Singer, D. V., Vincent, C. E., Korponay, T. C., D’Armiento, J., Lee, C. G., Elias, J. A., Singer, H. A., & Jaitovich, A. (2022) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2021-0351oc · Cited by 27
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Peng, J., Han, L., Liu, B., Song, J., Wang, Y., Wang, K., Guo, Q., Liu, X., Li, Y., Zhang, J., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-42837-8 · Cited by 28
Zhao, Y.-C., & Gao, B. (2024) · European Journal of Applied Physiology · doi:10.1007/s00421-024-05549-5 · Cited by 33
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Fan, Y., Richelme, S., Avazeri, É., Audebert, S., Helmbacher, F., Dono, R., & Maina, F. (2015) · PLoS Genetics · doi:10.1371/journal.pgen.1005533 · Cited by 27
Ikonomi, N., Werle, S. D., Schwab, J. D., & Kestler, H. A. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00848 · Cited by 29
Metadata
- Authors
- Rodgers, J. T., King, K. Y., Brett, J. O., Cromie, M. J., Charville, G. W., Maguire, K. K., Brunson, C., Mastey, N., Liu, L., Tsai, C.-R., Goodell, M. A., & Rando, T. A.
- Affiliations
- Stanford Medicine (US)
- Baylor College of Medicine (US)
- VA Palo Alto Health Care System (US)
- Corresponding author
- Rando, Thomas A.
- ORCID
- Venue
- Nature
- Published
- 2014-05-25
- Volume
- 510
- Issue
- 7505
- Pages
- 393-396
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC4065227
- OpenAlex
- W1964204876
- Cited by
- 776
- References
- 35
- Citations by year
- 2026: 48 · 2025: 51 · 2024: 65 · 2023: 93 · 2022: 71 · 2021: 72 · 2020: 64 · 2019: 63 · 2018: 59 · 2017: 80 · 2016: 43 · 2015: 53 · 2014: 14
- FWCI
- 25.82
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- U.S. Department of Veterans Affairs (I01 BX002324)
- China Scholarship Council
- National Institute on Aging (R37AG023806, K99AG041764, R01AG023806, F30AG035521, R01AG047820, P01AG036695)
- National Heart, Lung, and Blood Institute (K08HL098898)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK092883)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR062185)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Keywords
- stem cell quiescence, mTORC1, muscle stem cells, satellite cells, hepatocyte growth factor, tissue regeneration, injury response, cell cycle entry
- MeSH terms
- Mechanistic Target of Rapamycin Complex 1, Animals, Cell Cycle, Cells, Cultured, Gene Expression Regulation, Male, Mice, Inbred C57BL, Regeneration, Resting Phase, Cell Cycle, Muscle, Skeletal, Gene Expression Profiling, Satellite Cells, Skeletal Muscle, Multiprotein Complexes, Mice, TOR Serine-Threonine Kinases
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