The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
mTORC1 controls the adaptive transition of quiescent stem cells from G0 to GAlert
Open accessAbstract
A unique property of many adult stem cells is their ability to exist in a non-cycling, quiescent state. Although quiescence serves an essential role in preserving stem cell function until the stem cell is needed in tissue homeostasis or repair, defects in quiescence can lead to an impairment in tissue function. The extent to which stem cells can regulate quiescence is unknown. Here we show that the stem cell quiescent state is composed of two distinct functional phases, G0 and an 'alert' phase we term G(Alert). Stem cells actively and reversibly transition between these phases in response to injury-induced systemic signals. Using genetic mouse models specific to muscle stem cells (or satellite cells), we show that mTORC1 activity is necessary and sufficient for the transition of satellite cells from G0 into G(Alert) and that signalling through the HGF receptor cMet is also necessary. We also identify G0-to-G(Alert) transitions in several populations of quiescent stem cells. Quiescent stem cells that transition into G(Alert) possess enhanced tissue regenerative function. We propose that the transition of quiescent stem cells into G(Alert) functions as an 'alerting' mechanism, an adaptive response that positions stem cells to respond rapidly under conditions of injury and stress, priming them for cell cycle entry.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“inflammatory initiation of a cell cycle–primed Galert state in HSCs and other cells requires activation of mammalian target of rapamycin (Rodgers et al., 2014).”
From PU.1 enforces quiescence and limits hematopoietic stem cell expansion during inflammatory stress (2021) · cites this paper as Rodgers et al., 2014
Experimental — accuracy not yet measuredIn the citing paper
“Likewise, ‘priming’ of activation by systemic signaling factors has been reported to improve regeneration (Rodgers et al., 2014, 2017).”
From Aging induces aberrant state transition kinetics in murine muscle stem cells (2020) · cites this paper as Rodgers et al., 2014
In the citing paper
“Across all clusters, there were no distinct cell-cycle states observed, consistent with reports of the first division occurring ≥24 hours after our 18 h time point (Gilbert et al., 2010; Rodgers et al., 2014) (Fig. S2D).”
From Aging induces aberrant state transition kinetics in murine muscle stem cells (2020) · cites this paper as Rodgers et al., 2014
In the citing paper
“For instance, although we do not observe bistable transcriptional states between the most-quiescent and most-activated cells in our experiments, stable intermediary activation states might exist in vivo (Rodgers et al., 2014).”
From Aging induces aberrant state transition kinetics in murine muscle stem cells (2020) · cites this paper as Rodgers et al., 2014
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Adjusting batch effects in microarray expression data using empirical Bayes methods
Johnson, W. E., Li, C., & Rabinovic, A. (2007) · Biostatistics · doi:10.1093/biostatistics/kxj037 · Cited by 8,658
mTOR Signaling in Growth Control and Disease
Laplante, M., & Sabatini, D. M. (2012) · Cell · doi:10.1016/j.cell.2012.03.017 · Cited by 8,509
KEGG for integration and interpretation of large-scale molecular data sets
Kanehisa, M., Goto, S., Sato, Y., Furumichi, M., & Tanabe, M. (2012) · Nucleic Acids Research · doi:10.1093/nar/gkr988 · Cited by 4,848
Cellular and Molecular Regulation of Muscle Regeneration
CHARGÉ, S. B. P., & Rudnicki, M. A. (2004) · Physiological Reviews · doi:10.1152/physrev.00019.2003 · Cited by 2,691
Pax7 Is Required for the Specification of Myogenic Satellite Cells
Seale, P., Sabourin, L. A., Girgis-Gabardo, A., Mansouri, A., Gruß, P., & Rudnicki, M. A. (2000) · Cell · doi:10.1016/s0092-8674(00)00066-0 · Cited by 2,345
G 1 Events and Regulation of Cell Proliferation
Pardee, A. B. (1989) · Science · doi:10.1126/science.2683075 · Cited by 2,182
Wilson, A., Laurenti, E., Oser, G., van der Wath, R. C., Blanco-Bose, W., Jaworski, M., Offner, S., Dunant, C. F., Eshkind, L., Bockamp, E., et al. (2008) · Cell · doi:10.1016/j.cell.2008.10.048 · Cited by 1,908
Muscle injury activates resident fibro/adipogenic progenitors that facilitate myogenesis
Joe, A. W. B., Yi, L., Natarajan, A., Le Grand, F., So, L., Wang, J., Rudnicki, M. A., & Rossi, F. M. V. (2010) · Nature Cell Biology · doi:10.1038/ncb2015 · Cited by 1,690
Rainer Breitling, A., Armengaud, P., Anna Amtmann, A., & Herzyk, P. (2004) · FEBS Letters · doi:10.1016/j.febslet.2004.07.055 · Cited by 1,478
Uezumi, A., Fukada, S., Yamamoto, N., Takeda, S., & Tsuchida, K. (2010) · Nature Cell Biology · doi:10.1038/ncb2014 · Cited by 1,315
Flagged first, then by citations
Cited by
Sorted by citations
Items 101–200 of 774
A stem cell aging framework, from mechanisms to interventions
Liu, B., Qu, J. T., Zhang, W., Belmonte, J. C. I., & Liu, G. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111451 · Cited by 110
The AMPK/p27Kip1 Axis Regulates Autophagy/Apoptosis Decisions in Aged Skeletal Muscle Stem Cells
White, J. P., Billin, A. N., Campbell, M. E., Russell, A. J., Huffman, K. M., & Kraus, W. E. (2018) · Stem Cell Reports · doi:10.1016/j.stemcr.2018.06.014 · Cited by 104
Mitochondrial Role in Stemness and Differentiation of Hematopoietic Stem Cells
Papa, L., Djedaini, M., & Hoffman, R. (2019) · Stem Cells International · doi:10.1155/2019/4067162 · Cited by 108
Mechano-signaling via Piezo1 prevents activation and p53-mediated senescence of muscle stem cells
Peng, Y., Du, J., Günther, S., Guo, X., Wang, S., Schneider, A., Zhu, L., & Braun, T. W. (2022) · Redox Biology · doi:10.1016/j.redox.2022.102309 · Cited by 109
Huang, X., Pang, M.-J., Li, J.-Y., Chen, H., Sun, J., Song, Y., Ni, H.-J., Ye, S.-Y., Bai, S., Li, T., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-36310-9 · Cited by 115
Ganassi, M., & Zammit, P. S. (2022) · European Journal of Translational Myology · doi:10.4081/ejtm.2022.10064 · Cited by 111
Aging induces aberrant state transition kinetics in murine muscle stem cells
Kimmel, J. C., Hwang, A. B., Scaramozza, A., Marshall, W. F., & Brack, A. S. (2020) · Development · doi:10.1242/dev.183855 · Cited by 95
Li, N., Nakauka‐Ddamba, A., Tobias, J. W., Jensen, S. T., & Lengner, C. J. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.04.049 · Cited by 101
An ERK-Dependent Feedback Mechanism Prevents Hematopoietic Stem Cell Exhaustion
Baumgärtner, C., Toifl, S., Farlik, M., Halbritter, F., Scheicher, R., Fischer, I., Sexl, V., Bock, C., & Baccarini, M. (2018) · Cell stem cell · doi:10.1016/j.stem.2018.05.003 · Cited by 99
Poss, K. D., & Tanaka, E. M. (2024) · Cell stem cell · doi:10.1016/j.stem.2024.07.007 · Cited by 97
FOS licenses early events in stem cell activation driving skeletal muscle regeneration
Almada, A. E., Horwitz, N., Price, F. D., Gonzalez, A. E., Ko, M. Y., Bölükbaşı, Ö. V., Messemer, K. A., Chen, S., Sinha, M., Rubin, L. L., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2020.108656 · Cited by 98
Choi, W., Lee, J.-M., Lee, J.-H., Lee, S. H., & Kim, S. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00914 · Cited by 99
Dayanidhi, S., & Lieber, R. L. (2014) · Muscle & Nerve · doi:10.1002/mus.24441 · Cited by 99
Staufen1 inhibits MyoD translation to actively maintain muscle stem cell quiescence
de Morrée, A., van Velthoven, C. T. J., Gan, Q., Salvi, J. S., Klein, J. D. D., Akimenko, I., Quarta, M., Biressi, S., & Rando, T. A. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1708725114 · Cited by 100
Translational Control in Stem Cells
Tahmasebi, S., Amiri, M., & Sonenberg, N. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2018.00709 · Cited by 94
Adult stem cells and regenerative medicine—a symposium report
Cable, J., Fuchs, E. V., Weissman, I. L., Jasper, H., Glass, D. J., Rando, T. A., Blau, H. M., Debnath, S., Oliva, A. A., Park, S., et al. (2019) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.14243 · Cited by 93
PU.1 enforces quiescence and limits hematopoietic stem cell expansion during inflammatory stress
Chavez, J. S., Rabe, J. L., Loeffler, D., Higa, K. C., Hernandez, G., Mills, T. S., Ahmed, N., Gessner, R. L., Ke, Z., Idler, B. M., et al. (2021) · Journal of Experimental Medicine · doi:10.1084/jem.20201169 · Cited by 91
Quiescence Entry, Maintenance, and Exit in Adult Stem Cells
Mohammad, K., Dakik, P., Medkour, Y., Mitrofanova, D., & Titorenko, V. I. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20092158 · Cited by 94
The mitochondrial protein OPA1 regulates the quiescent state of adult muscle stem cells
Baker, N., Wade, S., Triolo, M., Girgis, J., Chwastek, D., Larrigan, S., Feige, P., Fujita, R., Crist, C. G., Rudnicki, M. A., et al. (2022) · Cell stem cell · doi:10.1016/j.stem.2022.07.010 · Cited by 96
Gasch, C., Ffrench, B., O’Leary, J. J., & Gallagher, M. F. (2017) · Molecular Cancer · doi:10.1186/s12943-017-0601-3 · Cited by 91
DDIT4 Licenses Only Healthy Cells to Proliferate During Injury-induced Metaplasia
Miao, Z., Sun, J.-X., Adkins-Threats, M., Pang, M.-J., Zhao, J.-H., Wang, X., Tang, K.-W., Wang, Z.-N., & Mills, J. C. (2020) · Gastroenterology · doi:10.1053/j.gastro.2020.09.016 · Cited by 90
Nguyen, P. D., Gurevich, D., Sonntag, C., Hersey, L., Alaei, S., Nim, H. T., Siegel, A., Hall, T. E., Rossello, F. J., Boyd, S. E., et al. (2017) · Cell stem cell · doi:10.1016/j.stem.2017.06.003 · Cited by 87
The cell biology of quiescent yeast – a diversity of individual scenarios
Sagot, I., & Laporte, D. (2019) · Journal of Cell Science · doi:10.1242/jcs.213025 · Cited by 90
Hepatocyte Growth Factor Activator: A Proteinase Linking Tissue Injury with Repair
Fukushima, T., Uchiyama, S., Tanaka, H., & Kataoka, H. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19113435 · Cited by 88
Acetylation of PAX7 controls muscle stem cell self-renewal and differentiation potential in mice
Sincennes, M., Brun, C. E., Lin, A. Y., Rosembert, T., Datzkiw, D., Saber, J., Hong, M., Kawabe, Y.-I., & Rudnicki, M. A. (2021) · Nature Communications · doi:10.1038/s41467-021-23577-z · Cited by 92
Mitochondrial Function in Muscle Stem Cell Fates
Bhattacharya, D., & Scimè, A. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00480 · Cited by 95
Dormant Intestinal Stem Cells Are Regulated by PTEN and Nutritional Status
Richmond, C. A., Shah, M. S., Deary, L. T., Trotier, D., Thomas, H. R., Ambruzs, D. M., Jiang, L., Whiles, B. B., Rickner, H., Montgomery, R. K., et al. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.11.035 · Cited by 93
Metabolic regulation of somatic stem cells in vivo
Meacham, C. E., DeVilbiss, A. W., & Morrison, S. J. (2022) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-022-00462-1 · Cited by 85
Chen, Z., Li, L., Wu, W., Liu, Z., Huang, Y., Yang, L., Luo, Q., Chen, J., Hou, Y., & Song, G. (2020) · Theranostics · doi:10.7150/thno.43577 · Cited by 88
Kann, A. P., Hung, M., Wang, W., Nguyen, J., Gilbert, P. M., Wu, Z., & Krauss, R. S. (2022) · Cell stem cell · doi:10.1016/j.stem.2022.04.016 · Cited by 82
Conditional knockin of Dnmt3a R878H initiates acute myeloid leukemia with mTOR pathway involvement
Dai, Y., Wang, Y., Huang, J.-Y., Li, X., Shi, X., Xu, J., Lu, J., Su, X., Yang, Y., Zhang, W., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1703476114 · Cited by 82
Transient HIF2A inhibition promotes satellite cell proliferation and muscle regeneration
Xie, L., Yin, A., Nichenko, A. S., Beedle, A. M., Call, J. A., & Yin, H. (2018) · Journal of Clinical Investigation · doi:10.1172/jci96208 · Cited by 84
Yue, F., Bi, P., Wang, C., Li, J., Liu, X., & Kuang, S. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.11.002 · Cited by 81
The paradox of metabolism in quiescent stem cells
Coller, H. A. (2019) · FEBS Letters · doi:10.1002/1873-3468.13608 · Cited by 82
Muscle Stem Cell Quiescence: Controlling Stemness by Staying Asleep
Ancel, S., Stuelsatz, P., & Feige, J. N. (2021) · Trends in Cell Biology · doi:10.1016/j.tcb.2021.02.006 · Cited by 79
Defining and identifying satellite cell-opathies within muscular dystrophies and myopathies
Ganassi, M., Muntoni, F., & Zammit, P. S. (2021) · Experimental Cell Research · doi:10.1016/j.yexcr.2021.112906 · Cited by 83
Dissecting Murine Muscle Stem Cell Aging through Regeneration Using Integrative Genomic Analysis
Shcherbina, A., Larouche, J., Fraczek, P., Yang, B. A., Brown, L. A., Markworth, J. F., Chung, C. H., Khaliq, M., de Silva, K., Choi, J. J., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.107964 · Cited by 76
Lipid droplet dynamics regulate adult muscle stem cell fate
Yue, F., Oprescu, S. N., Qiu, J., Gu, L., Zhang, L., Chen, J., Narayanan, N., Deng, M., & Kuang, S. (2022) · Cell Reports · doi:10.1016/j.celrep.2021.110267 · Cited by 80
Autophagy in muscle regeneration: potential therapies for myopathies
Chen, W., Chen, Y., Liu, Y., & Wang, X. (2022) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.13000 · Cited by 80
Farup, J., Rahbek, S. K., Knudsen, I. S., de Paoli, F. V., Mackey, A. L., & Vissing, K. (2014) · Amino Acids · doi:10.1007/s00726-014-1810-3 · Cited by 88
Hwang, A. B., & Brack, A. S. (2017) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2017.08.008 · Cited by 83
Stumm, J., Vallecillo-García, P., Hofe-Schneider, S. V., Ollitrault, D., Schrewe, H., Economides, A. N., Marazzi, G., Sassoon, D. A., & Stricker, S. (2018) · Stem Cell Research · doi:10.1016/j.scr.2018.08.010 · Cited by 78
Contribution of muscle satellite cells to sarcopenia
Huo, F., Liu, Q., & Liu, H. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.892749 · Cited by 74
Benjamin, D. I., Both, P., Benjamin, J. S., Nutter, C. W., Tan, J. H., Kang, J., Machado, L. A., Klein, J. D. D., de Morree, A., Kim, S., et al. (2022) · Cell Metabolism · doi:10.1016/j.cmet.2022.04.012 · Cited by 79
Interaction between epigenetic and metabolism in aging stem cells
Brunet, A., & Rando, T. A. (2017) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2016.12.009 · Cited by 79
Mechanisms regulating mammalian spermatogenesis and fertility recovery following germ cell depletion
La, H. M., & Hobbs, R. M. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03201-6 · Cited by 77
The CalcR-PKA-Yap1 Axis Is Critical for Maintaining Quiescence in Muscle Stem Cells
Zhang, L., Noguchi, Y.-T., Nakayama, H., Kaji, T., Tsujikawa, K., Ikemoto‐Uezumi, M., Uezumi, A., Okada, Y., Doi, T., Watanabe, S., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.10.057 · Cited by 74
Distinctive role of inflammation in tissue repair and regeneration
Choi, B., Lee, C., & Yu, J. (2023) · Archives of Pharmacal Research · doi:10.1007/s12272-023-01428-3 · Cited by 77
Sala, D., Cunningham, T. J., Stec, M. J., Etxaniz, U., Nicoletti, C., Dall’Agnese, A., Puri, P., Duester, G., Latella, L., & Sacco, A. (2019) · Nature Communications · doi:10.1038/s41467-019-09746-1 · Cited by 74
Paligenosis: Cellular Remodeling During Tissue Repair
Brown, J. W., Cho, C. J., & Mills, J. C. (2021) · Annual Review of Physiology · doi:10.1146/annurev-physiol-061121-035954 · Cited by 68
Neural Stem Cells and Nutrients: Poised Between Quiescence and Exhaustion
Cavallucci, V., Fidaleo, M., & Pani, G. (2016) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2016.06.007 · Cited by 73
Rao, T. N., Hansen, N., Stetka, J., Luque Paz, D., Kalmer, M., Hilfiker, J., Endele, M., Ahmed, N., Kubovcakova, L., Rybarikova, M., et al. (2021) · Blood · doi:10.1182/blood.2020005563 · Cited by 72
The Renaissance of Cyclin Dependent Kinase Inhibitors
Ettl, T., Schulz, D., & Bauer, R. J. (2022) · Cancers · doi:10.3390/cancers14020293 · Cited by 71
Cell senescence, rapamycin and hyperfunction theory of aging
Blagosklonny, M. V. (2022) · Cell Cycle · doi:10.1080/15384101.2022.2054636 · Cited by 74
Msi RNA-binding proteins control reserve intestinal stem cell quiescence
Yousefi, M., Li, N., Nakauka‐Ddamba, A., Wang, S., Davidow, K. A., Schoenberger, J., Yu, Z., Jensen, S. T., Kharas, M. G., & Lengner, C. J. (2016) · The Journal of Cell Biology · doi:10.1083/jcb.201604119 · Cited by 69
Transcriptional reprogramming in cellular quiescence
Roche, B., Arcangioli, B., & Martienssen, R. A. (2017) · RNA Biology · doi:10.1080/15476286.2017.1327510 · Cited by 69
A latent subset of human hematopoietic stem cells resists regenerative stress to preserve stemness
Kaufmann, K. B., Zeng, A. G. X., Coyaud, E., Garcia-Prat, L., Papalexi, E., Murison, A., Laurent, E. M. N., Chan-Seng-Yue, M., Gan, O. I., Pan, K., et al. (2021) · Nature Immunology · doi:10.1038/s41590-021-00925-1 · Cited by 68
Heterotopic Ossification: Clinical Features, Basic Researches, and Mechanical Stimulations
Xu, Y., Huang, M. H., He, W., He, C., Chen, K., Hou, J., Huang, M., Jiao, Y., Liu, R., Zou, N.-Y., et al. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.770931 · Cited by 74
Ultrafast distant wound response is essential for whole-body regeneration
Fan, Y., Chai, C., Li, P., Zou, X., Ferrell, J. E., & Wang, B. (2023) · Cell · doi:10.1016/j.cell.2023.06.019 · Cited by 68
Systemic cell cycle activation is induced following complex tissue injury in axolotl
Johnson, K. A., Bateman, J., DiTommaso, T., Wong, A. Y. L., & Whited, J. L. (2017) · Developmental Biology · doi:10.1016/j.ydbio.2017.07.010 · Cited by 68
Epigenetic control of adult skeletal muscle stem cell functions
Segalés, J., Perdiguero, E., & Muñoz‐Cánoves, P. (2014) · FEBS Journal · doi:10.1111/febs.13065 · Cited by 66
Evolutionarily divergent mTOR remodels translatome for tissue regeneration
Zhulyn, O., Rosenblatt, H. D., Shokat, L., Dai, S. A., Kuzuoğlu‐Öztürk, D., Zhang, Z., Ruggero, D., Shokat, K. M., & Barna, M. (2023) · Nature · doi:10.1038/s41586-023-06365-1 · Cited by 73
mTOR controls embryonic and adult myogenesis via mTORC1
Rion, N., Castets, P., Lin, S., Enderle, L., Reinhard, J. R., Eickhorst, C., & Rüegg, M. A. (2019) · Development · doi:10.1242/dev.172460 · Cited by 68
Systemic problems: a perspective on stem cell aging and rejuvenation.
Conboy, I. M., Conboy, M. J., & Rebo, J. (2015) · Aging · doi:10.18632/aging.100819 · Cited by 58
Biomaterials for endogenous regenerative medicine: Coaxing stem cell homing and beyond
Wu, R., Xu, X., Wang, J., He, X., Sun, H., & Chen, F. (2018) · Applied Materials Today · doi:10.1016/j.apmt.2018.02.004 · Cited by 67
Just, J., Yan, Y., Farup, J., Sieljacks, P., Sloth, M., Venø, M. T., Gu, T., de Paoli, F. V., Nyengaard, J. R., Bæk, R., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-62456-3 · Cited by 65
Three-dimensional imaging studies in mice identify cellular dynamics of skeletal muscle regeneration
Collins, B. C., Shapiro, J. B., Scheib, M. M., Musci, R. V., Verma, M., & Kardon, G. (2024) · Developmental Cell · doi:10.1016/j.devcel.2024.03.017 · Cited by 73
Dorà, N. J., Hill, R. E., Collinson, J. M., & West, J. D. (2015) · Stem Cell Research · doi:10.1016/j.scr.2015.10.016 · Cited by 64
Differences in muscle satellite cell dynamics during muscle hypertrophy and regeneration
Fukada, S., Higashimoto, T., & Kaneshige, A. (2022) · Skeletal Muscle · doi:10.1186/s13395-022-00300-0 · Cited by 71
Randolph, M. E., & Pavlath, G. K. (2015) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2015.00190 · Cited by 63
Kataoka, H., Kawaguchi, M., Fukushima, T., & Shimomura, T. (2018) · Pathology International · doi:10.1111/pin.12647 · Cited by 63
Sestrins in Physiological Stress Responses
Kim, M., Kowalsky, A. H., & Lee, J. H. (2020) · Annual Review of Physiology · doi:10.1146/annurev-physiol-031620-092317 · Cited by 66
Rando, T. A., Brunet, A., & Goodell, M. A. (2025) · Cell stem cell · doi:10.1016/j.stem.2025.06.004 · Cited by 68
Li, X., & Doetzlhofer, A. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2000417117 · Cited by 60
Advances in understanding the mechanism of zebrafish heart regeneration
Kikuchi, K. (2014) · Stem Cell Research · doi:10.1016/j.scr.2014.07.003 · Cited by 61
Wnt Signaling in Stem Cells and Cancer Stem Cells: A Tale of Two Coactivators
Kahn, M. (2017) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2017.11.007 · Cited by 62
EGFR signaling activates intestinal stem cells by promoting mitochondrial biogenesis and β-oxidation
Zhang, C., Jin, Y., Marchetti, M., Lewis, M. R., Hammouda, O. T., & Edgar, B. A. (2022) · Current Biology · doi:10.1016/j.cub.2022.07.003 · Cited by 59
Brorson, J., Lin, L., Wang, J., Bæk, A., Billeskov, T. B., Thybo, F. F., Just, J., Haskó, J., Ravn, C., Hansen, R. L., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-60627-2 · Cited by 60
Ffrench, B., Gasch, C., O’Leary, J. J., & Gallagher, M. F. (2014) · Molecular Cancer · doi:10.1186/1476-4598-13-262 · Cited by 58
Physiological Signaling and Structure of the HGF Receptor MET
Baldanzi, G., & Graziani, A. (2014) · Biomedicines · doi:10.3390/biomedicines3010001 · Cited by 56
GLI3 regulates muscle stem cell entry into GAlert and self-renewal
Brun, C. E., Sincennes, M., Lin, A. Y., Hall, D. T., Jarassier, W., Feige, P., Grand, F. L., Rudnicki, M. A., & Rudnicki, M. A. (2022) · Nature Communications · doi:10.1038/s41467-022-31695-5 · Cited by 57
Kimmel, J. C., Chang, A. Y., Brack, A. S., & Marshall, W. F. (2018) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1005927 · Cited by 54
Transcriptional and Chromatin Dynamics of Muscle Regeneration after Severe Trauma
Aguilar, C. A., Pop, R., Shcherbina, A., Watts, A., Matheny, R. W., Cacchiarelli, D., Han, W. M., Shin, E.-J., Nakhai, S. A., Jang, Y. C., et al. (2016) · Stem Cell Reports · doi:10.1016/j.stemcr.2016.09.009 · Cited by 53
Giordani, L., Parisi, A., & Grand, F. L. (2017) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2017.08.001 · Cited by 53
The Microenvironment Is a Critical Regulator of Muscle Stem Cell Activation and Proliferation
Nguyen, J. H. V., Chung, J. D., Lynch, G. S., & Ryall, J. G. (2019) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2019.00254 · Cited by 53
Satellite cells and their regulation in livestock
Gonzalez, M. L., Busse, N. I., Waits, C. M., & Johnson, S. (2020) · Journal of Animal Science · doi:10.1093/jas/skaa081 · Cited by 53
Kouri, F. M., Ritner, C., & Stegh, A. H. (2015) · Cell Cycle · doi:10.1080/15384101.2015.1093711 · Cited by 52
Damaged Myofiber-Derived Metabolic Enzymes Act as Activators of Muscle Satellite Cells
Tsuchiya, Y., Kitajima, Y., Masumoto, H., & Ono, Y. (2020) · Stem Cell Reports · doi:10.1016/j.stemcr.2020.08.002 · Cited by 52
Tomasso, A., Koopmans, T., Lijnzaad, P., Bartscherer, K., & Seifert, A. W. (2023) · Science Advances · doi:10.1126/sciadv.adf2331 · Cited by 48
D’Souza, D. M., Zhou, S., Rebalka, I. A., MacDonald, B., Moradi, J., Krause, M. P., Al‐Sajee, D., Punthakee, Z., Tarnopolsky, M. A., & Hawke, T. J. (2016) · Diabetes · doi:10.2337/db15-1577 · Cited by 50
Abreu, P., Mendes, S. V. D., Ceccatto, V. M., & Hirabara, S. M. (2016) · Life Sciences · doi:10.1016/j.lfs.2016.11.016 · Cited by 55
Abreu, P., & Kowaltowski, A. J. (2020) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12601 · Cited by 53
Repairing the lungs one breath at a time: How dedicated or facultative are you?Preprint
Leach, J. P., & Morrisey, E. E. (2018) · Genes & Development · doi:10.1101/gad.319418.118 · Cited by 52
Cardiac aging — Getting to the stem of the problem
Hariharan, N., & Sussman, M. A. (2015) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2015.04.008 · Cited by 48
Progenitor Cell Dysfunctions Underlie Some Diabetic Complications
Rodrigues, M., Wong, V., Rennert, R. C., Davis, C. R., Longaker, M. T., & Gurtner, G. C. (2015) · American Journal Of Pathology · doi:10.1016/j.ajpath.2015.05.003 · Cited by 49
Molecular Regulation of Cellular Quiescence: A Perspective from Adult Stem Cells and Its Niches
So, W., & Cheung, T. H. (2017) · Methods in molecular biology · doi:10.1007/978-1-4939-7371-2_1 · Cited by 49
Wound‐induced cell proliferation during animal regeneration
Ricci, L., & Srivastava, M. (2018) · Wiley Interdisciplinary Reviews Developmental Biology · doi:10.1002/wdev.321 · Cited by 49
Deep Convolutional and Recurrent Neural Networks for Cell Motility Discrimination and Prediction
Kimmel, J. C., Brack, A. S., & Marshall, W. F. (2019) · IEEE Transactions on Computational Biology and Bioinformatics · doi:10.1109/tcbb.2019.2919307 · Cited by 48
Jhaveri, D. J., O’Keeffe, I., Robinson, G. J., Zhao, Q., Zhang, Z. H., Nink, V., Narayanan, R. K., Osborne, G. W., Wray, N. R., & Bartlett, P. F. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.0504-15.2015 · Cited by 48
Neighboring cells override 3D hydrogel matrix cues to drive human MSC quiescence
Ferreira, S. A., Faull, P. A., Seymour, A. J., Yu, T. T. L., Loaiza, S., Auner, H. W., Snijders, A. P., & Gentleman, E. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.05.032 · Cited by 49
Metadata
- Authors
- Rodgers, J. T., King, K. Y., Brett, J. O., Cromie, M. J., Charville, G. W., Maguire, K. K., Brunson, C., Mastey, N., Liu, L., Tsai, C.-R., Goodell, M. A., & Rando, T. A.
- Affiliations
- Stanford Medicine (US)
- Baylor College of Medicine (US)
- VA Palo Alto Health Care System (US)
- Corresponding author
- Rando, Thomas A.
- ORCID
- Venue
- Nature
- Published
- 2014-05-25
- Volume
- 510
- Issue
- 7505
- Pages
- 393-396
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC4065227
- OpenAlex
- W1964204876
- Cited by
- 776
- References
- 35
- Citations by year
- 2026: 48 · 2025: 51 · 2024: 65 · 2023: 93 · 2022: 71 · 2021: 72 · 2020: 64 · 2019: 63 · 2018: 59 · 2017: 80 · 2016: 43 · 2015: 53 · 2014: 14
- FWCI
- 25.82
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- U.S. Department of Veterans Affairs (I01 BX002324)
- China Scholarship Council
- National Institute on Aging (R37AG023806, K99AG041764, R01AG023806, F30AG035521, R01AG047820, P01AG036695)
- National Heart, Lung, and Blood Institute (K08HL098898)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK092883)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR062185)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Keywords
- stem cell quiescence, mTORC1, muscle stem cells, satellite cells, hepatocyte growth factor, tissue regeneration, injury response, cell cycle entry
- MeSH terms
- Mechanistic Target of Rapamycin Complex 1, Animals, Cell Cycle, Cells, Cultured, Gene Expression Regulation, Male, Mice, Inbred C57BL, Regeneration, Resting Phase, Cell Cycle, Muscle, Skeletal, Gene Expression Profiling, Satellite Cells, Skeletal Muscle, Multiprotein Complexes, Mice, TOR Serine-Threonine Kinases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
