The DOI matches its Crossref record; 126 of the 126 references it cites were found in a registry or an index.
From circuits to behaviour in the amygdala
Open accessAbstract
The amygdala has long been associated with emotion and motivation, playing an essential part in processing both fearful and rewarding environmental stimuli. How can a single structure be crucial for such different functions? With recent technological advances that allow for causal investigations of specific neural circuit elements, we can now begin to map the complex anatomical connections of the amygdala onto behavioural function. Understanding how the amygdala contributes to a wide array of behaviours requires the study of distinct amygdala circuits.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“More recently, more in-depth research has illustrated that alterations in the HPA axis have been associated with the process of dealing with stress, especially toxic stress-induced negative health outcomes (83).”
From Epigenetic Modifications in Stress Response Genes Associated With Childhood Trauma (2019) · cites this paper as [83]
Experimental — accuracy not yet measuredIn the citing paper
“A growing appreciation for the complexity of the amygdala complex has resulted in a more nuanced understanding of this region’s role in fear learning, appetitive learning, and value encoding (Janak and Tye, 2015), and it is clear that the amygdala promotes adaptive behavioral responses to both positive and negative environmental stimuli.”
From A framework for understanding the emerging role of corticolimbic-ventral striatal networks in OCD-associated repetitive behaviors (2015) · cites this paper as Janak and Tye, 2015
In the citing paper
“In addition to a role in fear and threat conditioning, the amygdala also regulates anxiety.”
From A framework for understanding the emerging role of corticolimbic-ventral striatal networks in OCD-associated repetitive behaviors (2015) · cites this paper as Janak and Tye, 2015
In the citing paper
“Since the amygdala is central to processing these forms of information (Janak and Tye, 2015), aberrant communication of anxiety-related information from amygdala to VS could mediate anxiety-driven compulsive behavior.”
From A framework for understanding the emerging role of corticolimbic-ventral striatal networks in OCD-associated repetitive behaviors (2015) · cites this paper as Janak and Tye, 2015
In the citing paper
“The BNST and the CeA have been implicated in diverse behavioral functions (Davis et al., 2010, Janak and Tye, 2015, Kim et al., 2013)”
From Dorsal raphe dopamine neurons represent the experience of social isolation (2016) · cites this paper as Janak and Tye, 2015
In the citing paper
“In particular, given its access to primary sensory information, the CeA could orchestrate appropriate behavioral responses to salient stimuli with different valences [88,93].”
From Oxytocin Signaling in the Central Amygdala Modulates Emotion Discrimination in Mice (2019) · cites this paper as [93]
In the citing paper
“Processing of this sensory information in the BLA results in the formation of associations between neutral predictive stimuli and outcomes of positive or negative valence56 via Hebbian mechanisms57-59.”
From Resolving the neural circuits of anxiety (2015) · cites this paper as [56]
In the citing paper
“This interpretation is in part dictated by the individual’s previous experience and includes the assignment of valence to the stimulus via BLA circuits56.”
From Resolving the neural circuits of anxiety (2015) · cites this paper as [56]
In the citing paper
“the valence detection function of BLA projection neurons56 fits within the interpretation circuits described here, helping to determine whether a given stimulus is threatening or appetitive.”
From Resolving the neural circuits of anxiety (2015) · cites this paper as [56]
In the citing paper
“The BLA is critical for associative learning”
From Infraslow histaminergic dynamics govern priming states to gate moment-to-moment memory accessibility (2026) · cites this paper as [30]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Russell, J. A. (1980) · Journal of Personality and Social Psychology · doi:10.1037/h0077714 · Cited by 16,334
LeDoux, J. E. (2000) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.23.1.155 · Cited by 8,444
Fear memories require protein synthesis in the amygdala for reconsolidation after retrieval
Nader, K., Schafe, G. E., & Le Doux, J. E. (2000) · Nature · doi:10.1038/35021052 · Cited by 2,706
Adolphs, R., Tranel, D., Damasio, H., & Damasio, A. (1994) · Nature · doi:10.1038/372669a0 · Cited by 2,360
The role of the amygdala in fear and anxiety
Davis, M. (1992) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.15.030192.002033 · Cited by 2,357
THE AMYGDALA MODULATES THE CONSOLIDATION OF MEMORIES OF EMOTIONALLY AROUSING EXPERIENCES
McGaugh, J. L. (2004) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.27.070203.144157 · Cited by 2,296
THE COMPARATIVE ANATOMY OF THE NERVOUS SYSTEM OF VERTEBRATES INCLUDING MAN
Ariëns, K. C. U., Huber, G. C., & Grosby, E. C. (1936) · The Journal of Nervous and Mental Disease · doi:10.1097/00005053-193611000-00044 · Cited by 2,098
Neurons in medial prefrontal cortex signal memory for fear extinction
Milad, M. R., & Quirk, G. J. (2002) · Nature · doi:10.1038/nature01138 · Cited by 1,836
Phelps, E. A., Delgado, M. R., Nearing, K. I., & LeDoux, J. E. (2004) · Neuron · doi:10.1016/j.neuron.2004.08.042 · Cited by 1,753
Conscious and unconscious emotional learning in the human amygdala
Morris, J. S., Öhman, A., & Dolan, R. J. (1998) · Nature · doi:10.1038/30976 · Cited by 1,665
Research works printed but not linked: 1
- Kim, S.-Y. et al. Diverging neural pathways assemble a behavioural state from separable features in anxiety. Nature 496, 219–223 (2013). · DOI · Paper page
Cited by
Sorted by citations
Items 901–1,000 of 1,002
Prediction errors and valence: From single units to multidimensional encoding in the amygdala
Brockett, A. T., Vázquez, D., & Roesch, M. R. (2021) · Behavioural Brain Research · doi:10.1016/j.bbr.2021.113176 · Cited by 14
“Although some interspecies variation exists, across evolution the anatomical profile of the amygdala is highly conserved, and largely shared across species--from lizards to humans [3].”
BackgroundLal, P., & Kawakami, K. (2022) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2022.837527 · Cited by 17
“Although the amygdala is well known for processing and response to fear stimuli, it is also crucial for a broad range of behaviors such as emotion, cognition, and social behavior (Murray, 2007; Morrison and Salzman, 2010; O’Connell and Hofmann, 2011; Janak and Tye, 2015).”
BackgroundFolorunso, O. O., Harvey, T. L., Brown, S. E., Chelini, G., Berretta, S., & Balu, D. T. (2022) · Neuroscience Letters · doi:10.1016/j.neulet.2022.136958 · Cited by 15
The tricky business of defining brain functions
Rust, N. C., & LeDoux, J. E. (2022) · Trends in Neurosciences · doi:10.1016/j.tins.2022.10.011 · Cited by 15
A postmortem stereological study of the amygdala in Williams syndrome
Lew, C. H., Groeniger, K. M., Bellugi, U., Stefanacci, L., Schumann, C. M., & Semendeferi, K. (2017) · Brain Structure and Function · doi:10.1007/s00429-017-1592-y · Cited by 15
“2005; Murray 2007; Seymour and Dolan 2008; Janak and Tye 2015; but see; Goossens et al.”
BackgroundWide sensory filters underlie performance in memory-based discrimination and generalization
Chen, C., Krueger‐Burg, D., & de Hoz, L. (2019) · PLoS ONE · doi:10.1371/journal.pone.0214817 · Cited by 15
Neprilysin Controls the Synaptic Activity of Neuropeptides in the Intercalated Cells of the Amygdala
Gregoriou, G. C., Patel, S., Winters, B. L., & Bagley, E. E. (2020) · Molecular Pharmacology · doi:10.1124/mol.119.119370 · Cited by 15
“In particular, the amygdala participates in our learned fear responses, our responses to pain, and aspects of drug addiction (Janak and Tye, 2015), and endogenous opioids regulate all of these responses (Lutz andKieffer, 2013; Bodnar, 2018).”
BackgroundMattera, A., Pagani, M., & Baldassarre, G. (2020) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2020.569108 · Cited by 15
“…literature on the neural substrates underlying cued fear conditioning, extinction, and reinstatement revealed a very complex picture, involving many brain areas, such as the amygdala and the mPFC, and both long term potentiation (LTP) and depression (LTD) (Herry et al., 2010; Janak and Tye, 2015).”
BackgroundFunctional MRI of large scale activity in behaving micePreprint
Fonseca, M. S., Bergomi, M. G., Mainen, Z. F., & Shemesh, N. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.04.16.044941 · Cited by 15
“…of multiple reward-related areas such as the amygdala (AMG) and the anterior cingulate area (ACA), known to encode value (Cardinal et al., 2002; Janak & Tye, 2015; Kolling et al., 2016), as well as multiple hypothalamic areas (lateral hypothalamic area, LHA; medial/median preoptic area, MPO,…”
BackgroundLiang, T., Jin, Z., Lin, Y., Chen, Z., Li, Y., Xu, J., Yang, F., & Qin, L. (2025) · Military Medical Research · doi:10.1186/s40779-025-00600-8 · Cited by 15
“Amygdala, a brain region situated in the temporal lobe, includes two major nuclei: the basolateral complex of the amygdala (BLA) and the central nucleus of the amygdala (CeA) [58].”
Prioritization of social information by the basolateral amygdala in rats
Song, Z., Swarna, S., & Manns, J. R. (2021) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2021.107489 · Cited by 14
A 7-Tesla MRI study of the periaqueductal gray: resting state and task activation under threat
Weis, C., Bennett, K. P., Huggins, A. A., Parisi, E. A., Gorka, S. M., & Larson, C. L. (2021) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsab085 · Cited by 13
“While these concepts can be hard to disentangle definitively, the point is the PAGmay not be recruited during the current NPU task because it is not involved in the network of regions responsive to uncertainty or anticipation such as the amygdala, ACC, vmPFC and BNST, (Aupperle and Paulus, 2010; Drabant et al., 2011;…”
BackgroundInfluentialFujita, A., Zhong, L., Antony, M. S., Chamiec-Case, E., Mickelsen, L. E., Kanoski, S. E., Flynn, W. F., & Jackson, A. C. (2021) · Journal of Neuroscience · doi:10.1523/jneurosci.2600-20.2021 · Cited by 15
Kim, D., Jung, H., Shirai, Y., Kim, H., Kim, J., Lim, D., Mori, T., Lee, H., Park, D., Kim, H. Y., et al. (2021) · Biological Psychiatry · doi:10.1016/j.biopsych.2021.12.016 · Cited by 14
Shrinkage of olfactory amygdala connotes cognitive impairment in patients with Parkinson’s disease
Ay, U., Yıldırım, Z., Erdoğdu, E., Kıçık, A., Öztürk-Işık, E., Demıralp, T., & Gurvit, H. I. (2022) · Cognitive Neurodynamics · doi:10.1007/s11571-022-09887-y · Cited by 14
“This appraisal will become the “current value” of the stimulus at stake, transforming it into a conditioned stimulus and determining the decision to approach or avoid during the future exposures (Gallagher and Schoenbaum 1999 ; Janak and Tye 2015; Pessoa 2010).”
BackgroundAssociation between driving a car and retention of brain volume in Japanese older adults
Shimada, H., Bae, S., Harada, K., Makino, K., Chiba, I., Katayama, O., & Lee, S. (2022) · Experimental Gerontology · doi:10.1016/j.exger.2022.112010 · Cited by 15
“The amygdala is a subcortical nucleus with various functions such as emotion recognition, social cognition, and reward learning (Adolphs, 2010; Janak and Tye, 2015).”
Thalamus sends information about arousal but not valence to the amygdala
Leppla, C. A., Keyes, L. R., Glober, G. F., Matthews, G. A., Batra, K., Jay, M., Feng, Y., Chen, H. S., Mills, F., Delahanty, J., et al. (2022) · Psychopharmacology · doi:10.1007/s00213-022-06284-5 · Cited by 16
“For associative conditioning to occur, there must be NMDAR-dependent long-term potentiation in the amygdala (Clem and Huganir, 2010; Janak and Tye, 2015; McKernan and Shinnick-Gallagher, 1997; Rodrigues et al., 2001; Rogan et al., 1997; Rumpel et al., 2005; Tye et al., 2008).”
BackgroundSelf-citationUnbalanced amygdala communication in major depressive disorder
Wen, X., Han, B., Li, H., Dou, F., Wei, G., Hou, G., & Wu, X. (2023) · Journal of Affective Disorders · doi:10.1016/j.jad.2023.02.091 · Cited by 15
Emotional experience elicited by direct electrical stimulation: Case series and literature review
Hao, G., Zhou, X., Yan, H., Wang, X., Qiao, L., Ni, D., Shu, W., & Yu, T. (2023) · Epilepsia Open · doi:10.1002/epi4.12729 · Cited by 14
Brivio, P., Gallo, M. T., Gruca, P., Łasoń, M., Litwa, E., Fumagalli, F., Papp, M., & Calabrese, F. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24087321 · Cited by 14
“Examining the overall effects of NAC or VLX in the different brain regions, we found that the most consistent effects of NAC pretreatment on the response to the ARS, in comparison to the modulation exerted by VLX, were observed in the ventral hippocampus and amygdala, two limbic structures critical for the processing…”
BackgroundZhu, L., Zheng, D., Li, R., Shen, C.-J., Cai, R., Lyu, C., Tang, B., Sun, H. X., Wang, X., Ding, Y., et al. (2023) · Neuroscience Bulletin · doi:10.1007/s12264-023-01081-2 · Cited by 15
“Previous studies have also indicated that the amygdala is a key region for the fear response in both rodents and humans [2, 54].”
BackgroundResultBasolateral amygdala neuropeptide Y system modulates binge ethanol consumption
Robinson, S. L., Bendrath, S. C., Yates, E. M., & Thiele, T. E. (2023) · Neuropsychopharmacology · doi:10.1038/s41386-023-01742-w · Cited by 14
Kaźmierowska, A. M., Kostecki, M., Szczepanik, M., Nikolaev, T., Hamed, A., Michałowski, J. M., Wypych, M., Marchewka, A., & Knapska, E. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2302655120 · Cited by 15
Morphological Features of Human Dendritic Spines
Renner, J., & Rasia‐Filho, A. A. (2023) · Advances in neurobiology · doi:10.1007/978-3-031-36159-3_9 · Cited by 18
Aguirre, C. G., Woo, J. H., Romero-Sosa, J. L., Rivera, Z. M., Tejada, A. N., Munier, J. J., Perez, J., Goldfarb, M., Das, K., Gomez, M., et al. (2023) · Journal of Neuroscience · doi:10.1523/jneurosci.0622-23.2023 · Cited by 14
Liu, H., Lin, J., & Lin, W. (2024) · Frontiers in Psychology · doi:10.3389/fpsyg.2024.1354220 · Cited by 21
“The amygdala is vital for emotion processing, particularly in handling negative emotions like fear, anger, and anxiety (Janak and Tye, 2015).”
BackgroundFunctional connectivity of the amygdala subnuclei in various mood states of bipolar disorder
Krystal, S., Gracia, L., Piguet, C., Henry, C., Alonso, M., Polosan, M., Savatovsky, J., Houenou, J., & Favre, P. (2024) · Molecular Psychiatry · doi:10.1038/s41380-024-02580-y · Cited by 16
Uselman, T. W., Barto, D. R., Jacobs, R. E., & Bearer, E. L. (2020) · NeuroImage · doi:10.1016/j.neuroimage.2020.116975 · Cited by 13
Neuroimaging markers of chronic fatigue in older people: a narrative review
Angioni, D., Giudici, K. V., Montoya-Martínez, M., Rolland, Y., Vellas, B. J., & Barreto, P. D. S. (2020) · Aging Clinical and Experimental Research · doi:10.1007/s40520-020-01666-1 · Cited by 14
Oliveira, V. E. D. M., A, T. R. D. J., & Neumann, I. D. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.906617 · Cited by 13
“The amygdala complex (especially the basolateral amygdala→CeA pathway) has been implicated in processes such as valence encoding (Janak and Tye, 2015) and empathy/emotion recognition (Klein and Gogolla, 2021).”
BackgroundFear Learning: An Evolving Picture for Plasticity at Synaptic Afferents to the Amygdala
Palchaudhuri, S., Osypenko, D., & Schneggenburger, R. (2022) · The Neuroscientist · doi:10.1177/10738584221108083 · Cited by 15
“The amygdala has long been recognized as a brain area that integrates and processes information about sensory cues and that is involved in the execution of defensive or approach behaviors, depending on the valence of the perceived cues (Janak and Tye 2015; Paton and others 2006).”
BackgroundMaurus, I., Röll, L., Keeser, D., Karali, T., Papazov, B., Hasan, A., Schmitt, A., Papazova, I., Lembeck, M., Hirjak, D., et al. (2022) · Schizophrenia · doi:10.1038/s41537-022-00269-1 · Cited by 15
Sedwick, V. M., & Autry, A. E. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104893 · Cited by 15
Chang, M. Y.-H., Liu, S.-W., & Chang, C. (2017) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2017.12.011 · Cited by 14
“By protecting an individual from life-threatening conditions, fear stands its vital role in evolution (Janak & Tye, 2015; LeDoux, 1996; Mineka & Ohman, 2002).”
BackgroundSerfling, G., Buades‐Rotger, M., Harbeck, B., Krämer, U. M., & Brabant, G. E. (2018) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2018.09.007 · Cited by 13
Molecular basis for and chemogenetic modulation of comorbidities in GABRG 2‐deficient epilepsies
Zhang, C., McMahon, B., Dong, H., Warner, T. A., Shen, W., Gallagher, M. J., Macdonald, R. L., & Kang, J. (2019) · Epilepsia · doi:10.1111/epi.15160 · Cited by 15
Brand, R., & Ulrich, L. (2019) · Frontiers in Psychology · doi:10.3389/fpsyg.2019.02901 · Cited by 14
“It is known that amygdalo-subcortical areas contribute especially to negative affective responses (e.g., Janak and Tye, 2015).”
BackgroundXie, Y., Zhang, Y., Hu, T., Zhao, Z., Liu, Q., & Li, H. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.932939 · Cited by 14
“The amygdala, associated with emotion and motivation, plays roles in processing rewarding environmental stimulus (Janak and Tye, 2015).”
BackgroundInnate visual preferences and behavioral flexibility in Drosophila
Grabowska, M. J., Steeves, J. B., Alpay, J., Poll, M. N. V. D., Ertekin, D., & van Swinderen, B. (2018) · Journal of Experimental Biology · doi:10.1242/jeb.185918 · Cited by 13
“However, the valence of stimuli is not necessarily hard-wired (Janak and Tye, 2015).”
BackgroundSoares, J. A. G., Sutley-Koury, S. N., Pomrenze, M. B., & Tucciarone, J. (2025) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2024.1521016 · Cited by 14
“…extended amygdala, i.e., central amygdala (CeA), bed nucleus of stria terminalis (BNST), and NAc integrate stress and reward pathways and are thought to contribute to the negative affective states and reinforcement that maintains opioid dependence (Janak and Tye, 2015; Wilson and McDonald, 2020).”
Prefrontal encoding of an internal model for emotional inference
Gu, X., & Johansen, J. P. (2025) · Nature · doi:10.1038/s41586-025-09001-2 · Cited by 19
“2a and Supplementary Information 3).”
InfluentialResearch progress on the neural circuits mechanisms of anxiety
Gong, W. (2025) · Frontiers in Neural Circuits · doi:10.3389/fncir.2025.1609145 · Cited by 18
“Structurally, the amygdala consists of multiple subdivisions, among which the BLA and CeA are particularly critical for orchestrating different aspects of anxiety-like behaviors (Janak and Tye, 2015).”
Sex Differences in Adolescent Neurobiological Risk for Substance Use and Substance Use Disorders
Dir, A. L., & Hulvershorn, L. A. (2019) · Current Addiction Reports · doi:10.1007/s40429-019-00276-w · Cited by 14
Bigot, M., Vicq, É., Lledo, P., Alonso, M., & Henry, C. (2022) · Scientific Reports · doi:10.1038/s41598-022-10965-8 · Cited by 13
Li, J., Chen, K. M., & Sheets, P. L. (2022) · The Journal of Comparative Neurology · doi:10.1002/cne.25332 · Cited by 11
“…complex (BLA; the primary sensory input zone of the amygdala) and the central amygdala (CeA; the major output structure of the amygdala) (Janak & Tye, 2015; Marek et al., 2013; Neugebauer et al., 2004; Pape & Pare, 2010; This is an open access article under the terms of the Creative Commons…”
BackgroundLi, J., Yu, Y., Su, C.-L., Shen, Y., Chang, C., & Gean, P. (2022) · Neuropsychopharmacology · doi:10.1038/s41386-022-01417-y · Cited by 13
Contributions of human amygdala nuclei to resting-state networks
Elvira, U. K., Seoane, S., Janssen, J., & Janssen, N. (2022) · PLoS ONE · doi:10.1371/journal.pone.0278962 · Cited by 13
Modulation of aversive value coding in the vertebrate and invertebrate brain
Perisse, E., Miranda, M., & Trouche, S. G. (2023) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2023.102696 · Cited by 12
Molecular diversity and functional dynamics in the central amygdala
Yeh, L.-F., Zuo, S., & Liu, P.-W. (2024) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2024.1364268 · Cited by 15
Circuit formation and sensory perception in the mouse olfactory system
Mori, K., & Sakano, H. (2024) · Frontiers in Neural Circuits · doi:10.3389/fncir.2024.1342576 · Cited by 13
“It is assumed that recalled scene-memory further activates specific valence regions in the amygdala, which were connected to the memory engram (Josselyn and Tonegawa, 2020) in the previous experience (Motanis et al., 2014; Janak and Tye, 2015; Jin et al., 2015; East et al., 2021).”
BackgroundZeisler, Z. R., Heslin, K. A., Stoll, F. M., Hof, P. R., Clem, R. L., & Rudebeck, P. H. (2024) · Current Biology · doi:10.1016/j.cub.2024.06.012 · Cited by 14
Posterior Basolateral Amygdala is a Critical Amygdaloid Area for Temporal Lobe Epilepsy
Sun, Y., Hu, B., Tan, L., Lin, L., Cao, S., Wu, T., Wang, H., Yu, B., Wang, Q., Lian, H., et al. (2024) · Advanced Science · doi:10.1002/advs.202407525 · Cited by 13
Sex Differences in Central Amygdala Glutamate Responses to Calcitonin Gene-Related Peptide
Lorsung, R. M., Cramer, N., Alipio, J. B., Ji, Y., Han, S., Masri, R. M., & Keller, A. (2024) · Journal of Neuroscience · doi:10.1523/jneurosci.1898-24.2024 · Cited by 13
Amygdala intercalated cells form an evolutionarily conserved system orchestrating brain networks
Aksoy‐Aksel, A., Ferraguti, F., Holmes, A., Lüthi, A., & Ehrlich, I. (2024) · Nature Neuroscience · doi:10.1038/s41593-024-01836-8 · Cited by 16
“ITC vm/av also exert inhibitory control over BA→nucleus accumbens (NAc) projection neurons 80 , which have a role in positive valence and reward-value processing 2 .”
Cross, E. A., Borland, J. M., Shaughnessy, E. K., Lee, S. D., Vu, V., Sambor, E. A., Meisel, R. L., Huhman, K. L., & Albers, H. E. (2025) · Psychopharmacology · doi:10.1007/s00213-025-06793-z · Cited by 18
“Under - scoring the importance of the MDS, however, recent studies show that the LHb and LS affect behavior through GAB - Aergic inhibition of DA neurons in the VTA (Hu 2016; Li et al. 2022 ).”
InfluentialA brain center that controls consummatory responses
Canovas, J. A., Wang, L., Mohamed, A. A. M., Abbott, L. F., & Zuker, C. S. (2025) · Cell · doi:10.1016/j.cell.2025.08.021 · Cited by 15
Zhou, F., Zhang, R., Yao, S., Dong, D., Feng, P., Kranz, G. S., Feng, T., & Becker, B. (2025) · IEEE Transactions on Affective Computing · doi:10.1109/taffc.2025.3624391 · Cited by 11
“…utilizing network-level information, such as functional connectivity, may better capture attentional and affective changes in dynamic naturalistic environments [34], [35], [36], [37], aligning with the importance of dynamic brain system interactions in animal models [1], [2], [3], [4], [5], [38].”
InfluentialParent, M. B., Ferreira‐Neto, H. C., Kruemmel, A. R., Althammer, F., Patel, A. A., Keo, S., Whitley, K. E., Cox, D. N., & Stern, J. E. (2021) · Behavioural Brain Research · doi:10.1016/j.bbr.2021.113452 · Cited by 11
Amygdala in Action: Functional Connectivity during Approach and Avoidance Behaviors
Leitão, J., Burckhardt, M., & Vuilleumier, P. O. (2021) · Journal of Cognitive Neuroscience · doi:10.1162/jocn_a_01800 · Cited by 16
Crofton, E. J., Zhu, M., Curtis, K. N., Nolan, G. W., O’Buckley, T. K., Morrow, A. L., & Herman, M. A. (2021) · Neuropharmacology · doi:10.1016/j.neuropharm.2021.108912 · Cited by 13
Kaya, B., Geha, P., de Araújo, I. E., Cioffi, I., & Moayedi, M. (2022) · Human Brain Mapping · doi:10.1002/hbm.26104 · Cited by 13
“These networks are involved in mediating the impact of Pavlovian associations on decision-making (Janak & Tye, 2015).”
BackgroundInfluentialZan, G., Wang, Q., Wang, Y.-J., Chen, J.-C., Wu, X. L., Yang, C., Chai, J., Li, M., Liu, Y., Hu, X., et al. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.01.052 · Cited by 13
“The amygdala is another key brain region that is associated with the aversive events in both human and rodents (Zald and Pardo, 1997; Janak and Tye, 2015).”
BackgroundSantiago, A. N., Aoki, C. J., & Sullivan, R. M. (2017) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2016.12.010 · Cited by 14
You, C., Vandegrift, B. J., Zhang, H., Lasek, A. W., Pandey, S. C., & Brodie, M. S. (2018) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.13870 · Cited by 13
de Vliet, L. V., Jastorff, J., Huang, Y., Paesschen, W. V., Vandenbulcke, M., & den Stock, J. V. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.0634-18.2018 · Cited by 13
“This is in line with a functional hypothesis of the amygdala as a personal relevance detector and modulator of brain processes underlying adaptive behavior (Sander et al., 2003; Janak and Tye, 2015).”
ResultParabrachial-to-amygdala control of aversive learning
Nagase, M., Mikami, K., & Watabe, A. M. (2018) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2018.08.005 · Cited by 13
Koizumi, R., Kiyokawa, Y., Tanaka, K., Tanikawa, T., & Takeuchi, Y. (2019) · Journal of Veterinary Medical Science · doi:10.1292/jvms.19-0040 · Cited by 13
Subcortical Volume Correlates of Psychological Distress in Early Adolescence
Broadhouse, K. M., Boyes, A., Winks, N., Dokonal, T., McLoughlin, L. T., Parker, M. J., Beaudequin, D. A., Simcock, G. P., Lagopoulos, J., & Hermens, D. F. (2019) · Developmental Neuroscience · doi:10.1159/000502339 · Cited by 13
Reducing Amygdala Activity and Phobic Fear through Cognitive Top–Down Regulation
Loos, E., Schicktanz, N. S., Fastenrath, M., Coynel, D., Milnik, A., Fehlmann, B., Egli, T., Ehrler, M., Papassotiropoulos, A., & de Quervain, D. J. ‐. (2020) · Journal of Cognitive Neuroscience · doi:10.1162/jocn_a_01537 · Cited by 14
“The amygdala is fundamentally involved in processing emotional stimuli of positive and negative valence (Janak & Tye, 2015), including fear in animals (Fanselow & Gale, 2003; Davis & Whalen, 2001) and humans (Shin & Liberzon, 2010; LeDoux, 2007; Adolphs, Tranel, Damasio, & Damasio, 1995).”
BackgroundElucidating memory in the brain via single‐cell transcriptomics
Sullivan, K. E., Kendrick, R. M., & Cembrowski, M. S. (2020) · Journal of Neurochemistry · doi:10.1111/jnc.15250 · Cited by 11
“Of critical importance to the neuroscience of memory, the hippocampus and the amygdala are brain regions that are conserved in structure and function between mice and humans (Janak & Tye, 2015; Strange et al., 2014).”
BackgroundMolecular taxonomy of the primate amygdala via single-nucleus RNA sequencing analysis
Zhang, L., Cheng, Y., Wu, S., Lu, Y., Xue, Z., Chen, X., Chen, D., Zhang, B., Qiu, Z., & Jiang, H. (2021) · 中国科学通报：英文版 · doi:10.1016/j.scib.2021.01.017 · Cited by 13
Boyle, C. A., Hu, B., Quaintance, K. L., & Lei, S. (2021) · The Journal of Physiology · doi:10.1113/jp281260 · Cited by 12
“The amygdala is an essential brain region involved in modulating defensive (Ressler, 2010; Tye et al. 2011; Dejean et al. 2015; Janak & Tye, 2015) and appetitive (Petrovich, 2011, 2013; Zanchi et al. 2017; Smith & Lawrence, 2018) behaviour, pain (Neugebauer et al. 2004; Veinante et al. 2013;…”
BackgroundYoon, L., Rohrsetzer, F., Battel, L., Anés, M., Manfro, P. H., Rohde, L. A., Viduani, A. C., Zajkowska, Z., Mondelli, V., Kieling, C., et al. (2021) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.13496 · Cited by 13
Altered brain network in first-episode, drug-naive patients with major depressive disorder
Liu, J., Zhu, Q., Zhu, L., Yang, Y. Q., Zhang, Y., Liu, X., Zhang, L., Jia, Y., Peng, Q., Wang, J., et al. (2021) · Journal of Affective Disorders · doi:10.1016/j.jad.2021.10.012 · Cited by 13
Sun, J., Lu, Y., Yang, J., Song, Z., Lu, W., & Wang, J. (2020) · Journal of Molecular Neuroscience · doi:10.1007/s12031-020-01570-3 · Cited by 12
Basolateral and central amygdala orchestrate how we learn whom to trust
Sladky, R., Riva, F., Rosenberger, L. A., van Honk, J., & Lamm, C. (2021) · Communications Biology · doi:10.1038/s42003-021-02815-6 · Cited by 16
Hippocampus Modulates Vocalizations Responses at Early Auditory Centers
Leong, A. T. L., Wong, E. C., Wang, X., & Wu, E. X. (2023) · NeuroImage · doi:10.1016/j.neuroimage.2023.119943 · Cited by 14
Dang, Q., Ma, F., Yuan, Q., Fu, Y., Chen, K., Zhang, Z., Lu, C., & Guo, T. (2023) · Cerebral Cortex · doi:10.1093/cercor/bhad121 · Cited by 14
A view-based decision mechanism for rewards in the primate amygdala
Fabian Grabenhorst, B., Ponce‐Alvarez, A., Battaglia‐Mayer, A., Deco, G., & Schultz, W. (2023) · Neuron · doi:10.1016/j.neuron.2023.08.024 · Cited by 11
“dLA specialization for object valuation aligns with this structure’s rich visual inputs,(30) highly selective object responses,(48) and known function in associating stimuli with value.(45,46) In our model, object values were converted to view-based values through feedforward convergence and integral feedback control…”
BackgroundCue- versus reward-encoding basolateral amygdala projections to nucleus accumbens
He, Y., Huang, Y. H., Schlüter, O. M., & Dong, Y. (2023) · eLife · doi:10.7554/elife.89766 · Cited by 12
“BLA pyramidal neurons heterogeneously respond to US, CS, as well as stimuli with appetitive or aversive valence ( Janak and Tye, 2015 ; O’Neill et al., 2018 ; Gründemann et al., 2019 ).”
BackgroundAn amygdalar oscillator coordinates cellular and behavioral rhythms
Liu, Q., Xiong, J., Kim, D. W., Lee, S., Bell, B. J., Alexandre, C., Blackshaw, S., Latrémolière, A., & Wu, M. N. (2024) · Neuron · doi:10.1016/j.neuron.2024.08.013 · Cited by 12
Gradient descent optimization of acoustic holograms for transcranial focused ultrasound
Sallam, A., Cengiz, C., Pewekar, M. M., Hoffmann, E., Legon, W., Vlaisavljevich, E., & Shahab, S. (2024) · Journal of Applied Physics · doi:10.1063/5.0220486 · Cited by 12
Chen, Y., Huang, J., Zhou, Z., Zhang, J., Jin, C., Zeng, X., Jia, J., & Li, L. (2024) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2024.117411 · Cited by 12
Munguba, H., Srivastava, I., Gutzeit, V. A., Singh, A., Vijay, A., Kristt, M., Arefin, A., Thukral, S., Broichhagen, J., Stujenske, J. M., et al. (2024) · Neuron · doi:10.1016/j.neuron.2025.01.002 · Cited by 13
Amygdalo-cortical dialogue underlies memory enhancement by emotional association
Saito, Y., Osako, Y., Odagawa, M., Oisi, Y., Matsubara, C., Kato, S., Kobayashi, K., Morita, M., Johansen, J. P., & Murayama, M. (2025) · Neuron · doi:10.1016/j.neuron.2025.01.001 · Cited by 14
Cortical representations of affective pain shape empathic fear in male mice
Choi, J., Lee, Y., So, D., Kim, J. Y., Choi, S., Kim, S., & Keum, S. (2025) · Nature Communications · doi:10.1038/s41467-025-57230-w · Cited by 12
“The BLA is considered one of the fundamental neural structures for encoding negative and positive affective valences 69,70 .”
Wang, L., Xiong, X., Liu, J., Liu, R., Liao, J., Fan, L., Lu, S., Wang, W., Zhuo, L., & Li, H. (2025) · Journal of Neurology · doi:10.1007/s00415-025-12934-3 · Cited by 12
“Thus, the amygdala is thought to play a key role in the recognition and processing of emotions (especially negative emotions such as fear), emotional memory, and rewarding stimuli [75, 76].”
Kim, E. S., & Lattal, K. M. (2019) · eNeuro · doi:10.1523/eneuro.0203-19.2019 · Cited by 11
“Appetitive and aversive outcomes, as well as cues that predict them, evoke dopamine efflux to the amygdala where D1- and D2-like receptors are expressed (Hurd et al., 1997; Guarraci et al., 1999, 2000; Weiss et al., 2000; Fotros et al., 2013; Abraham et al., 2014; Janak and Tye, 2015).”
BackgroundEndocrine adaptations across physical and psychological stressors in long-term space flights
Angeloni, D., & Demontis, G. C. (2020) · Current Opinion in Endocrine and Metabolic Research · doi:10.1016/j.coemr.2019.12.005 · Cited by 13
Równiak, M., & Bogus‐Nowakowska, K. (2020) · Journal of Anatomy · doi:10.1111/joa.13148 · Cited by 11
“…the temporal lobe of the brain which is involved in various aspects of emotional behaviour and emotional learning (LeDoux, 2003; Pape & Pare, 2010; Janak & Tye, 2015), particularly fear (LeDoux, 2003; Feinstein et al. 2011), anxiety Correspondence Maciej R owniak, Department of Animal Anatomy and…”
BackgroundThe role of sleep in emotional processing: insights and unknowns from rodent research
Trouche, S. G., Pompili, M. N., & Girardeau, G. (2020) · Current Opinion in Physiology · doi:10.1016/j.cophys.2020.04.003 · Cited by 15
“In particular, the basolateral amygdala (BLA) is where the emotional valence of a stimulus (aversive or appetitive; [12,13]) is associated with a sensory and/or contextual stimulus in conditioning paradigms [14].”
BackgroundNeuronal oscillations and the mouse prefrontal cortex
Jung, F., & Carlén, M. (2021) · International review of neurobiology · doi:10.1016/bs.irn.2020.11.005 · Cited by 12
Lewy bodies in the olfactory system and the hypothalamus
Cersosimo, M. G., Benarroch, E. E., & Raina, G. B. (2021) · Handbook of clinical neurology · doi:10.1016/b978-0-12-819973-2.00016-2 · Cited by 14
Central Nervous System Associated With Light Perception and Physiological Responses of Birds
Kang, S. W. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.723454 · Cited by 17
“The major brain structures associated with positive emotion are the amygdala complex and nucleus accumbens (Janak and Tye, 2015).”
BackgroundHall, N. T., & Hallquist, M. N. (2022) · Psychological Medicine · doi:10.1017/s0033291722000101 · Cited by 12
“While CeN encodes the general affective and motivational significance of emotional events (Balleine & Killcross, 2006; Corbit & Balleine, 2005), BLA is involved in assigning emotional significance to sensory stimuli (Janak & Tye, 2015; Namburi et al., 2015).”
Casey, E., Avale, M. E., Kravitz, A. V., & Rubinstein, M. (2023) · Brain Structure and Function · doi:10.1007/s00429-023-02614-1 · Cited by 12
“2018), connectivity and functions (McCullough et al. 2018; Janak and Tye 2015; Kim et al. 2017).”
Amygdala neurocircuitry at the interface between emotional regulation and narcolepsy with cataplexy
Sardar, H., Goldstein‐Piekarski, A. N., & Giardino, W. J. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1152594 · Cited by 12
“While the AMY has historically been primarily studied in the context of threat avoidance and fear conditioning (LeDoux, 2000; Phelps and LeDoux, 2005), extensive research has linked the AMY not only with negative emotional states of anxiety and aversion, but with positive emotional states of approach and reward as wel…”
BackgroundMucha, M. W., Skrzypiec, A. E., Kolenchery, J. B., Brambilla, V., Patel, S., Labrador-Ramos, A., Kudla, L., Murrall, K., Skene, N., Dymicka-Piekarska, V., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-37688-2 · Cited by 14
“CeA and BNST relay emotionally relevant neural signals to the downstream brain centres responsible for the expression of behavioural reactions (e.g. risk avoidance, low food intake, social avoidance, increase in blood pressure and heart rate) that collectively assemble anxiety-like states 7,8,10 .”
Potentiation of cholinergic and corticofugal inputs to the lateral amygdala in threat learning
Asokan, M. M., Watanabe, Y. L., Kimchi, E. Y., & Polley, D. B. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.113167 · Cited by 15
Learning and Memory in Addiction
Carmack, S. A., Koob, G. F., & Anagnostaras, S. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-809324-5.21101-2 · Cited by 13
Metadata
- Authors
- Janak, P. H., & Tye, K. M.
- Affiliations
- Johns Hopkins University (US)
- Massachusetts Institute of Technology (US)
- Corresponding author
- Janak, Patricia H.
- Tye, Kay M.
- Venue
- Nature
- Published
- 2015-01-14
- Volume
- 517
- Issue
- 7534
- Pages
- 284-292
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC4565157
- OpenAlex
- W1989982790
- Cited by
- 2,011
- References
- 126
- Citations by year
- 2026: 149 · 2025: 193 · 2024: 198 · 2023: 210 · 2022: 207 · 2021: 234 · 2020: 225 · 2019: 172 · 2018: 132 · 2017: 119 · 2016: 114 · 2015: 56
- FWCI
- 13.69
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- DSpace@MIT (Massachusetts Institute of Technology) (submittedVersion, cc-by-nc-sa)
- PMC
- Funders
- New York Stem Cell Foundation
- JPB Foundation
- National Institutes of Health
- National Institute on Alcohol Abuse and Alcoholism (R01AA014925, AA17072, AA014925, P50AA017072, R01AA016835)
- National Institute of Mental Health (R01MH102441, MH102441, R37MH102441)
- National Institute on Drug Abuse (DA015096, R01DA015096, R01DA035943)
- National Institute of Diabetes and Digestive and Kidney Diseases (DP2DK102256)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- amygdala, neural circuits, emotions, motivation, fear, reward, behavioural function, structural connectivity, causal manipulation
- MeSH terms
- Amygdala, Animals, Behavior, Biological Evolution, Fear, Humans, Memory, Neural Pathways, Reward
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
