The DOI matches its Crossref record; 126 of the 126 references it cites were found in a registry or an index.
From circuits to behaviour in the amygdala
Open accessAbstract
The amygdala has long been associated with emotion and motivation, playing an essential part in processing both fearful and rewarding environmental stimuli. How can a single structure be crucial for such different functions? With recent technological advances that allow for causal investigations of specific neural circuit elements, we can now begin to map the complex anatomical connections of the amygdala onto behavioural function. Understanding how the amygdala contributes to a wide array of behaviours requires the study of distinct amygdala circuits.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“More recently, more in-depth research has illustrated that alterations in the HPA axis have been associated with the process of dealing with stress, especially toxic stress-induced negative health outcomes (83).”
From Epigenetic Modifications in Stress Response Genes Associated With Childhood Trauma (2019) · cites this paper as [83]
Experimental — accuracy not yet measuredIn the citing paper
“A growing appreciation for the complexity of the amygdala complex has resulted in a more nuanced understanding of this region’s role in fear learning, appetitive learning, and value encoding (Janak and Tye, 2015), and it is clear that the amygdala promotes adaptive behavioral responses to both positive and negative environmental stimuli.”
From A framework for understanding the emerging role of corticolimbic-ventral striatal networks in OCD-associated repetitive behaviors (2015) · cites this paper as Janak and Tye, 2015
In the citing paper
“In addition to a role in fear and threat conditioning, the amygdala also regulates anxiety.”
From A framework for understanding the emerging role of corticolimbic-ventral striatal networks in OCD-associated repetitive behaviors (2015) · cites this paper as Janak and Tye, 2015
In the citing paper
“Since the amygdala is central to processing these forms of information (Janak and Tye, 2015), aberrant communication of anxiety-related information from amygdala to VS could mediate anxiety-driven compulsive behavior.”
From A framework for understanding the emerging role of corticolimbic-ventral striatal networks in OCD-associated repetitive behaviors (2015) · cites this paper as Janak and Tye, 2015
In the citing paper
“The BNST and the CeA have been implicated in diverse behavioral functions (Davis et al., 2010, Janak and Tye, 2015, Kim et al., 2013)”
From Dorsal raphe dopamine neurons represent the experience of social isolation (2016) · cites this paper as Janak and Tye, 2015
In the citing paper
“In particular, given its access to primary sensory information, the CeA could orchestrate appropriate behavioral responses to salient stimuli with different valences [88,93].”
From Oxytocin Signaling in the Central Amygdala Modulates Emotion Discrimination in Mice (2019) · cites this paper as [93]
In the citing paper
“Processing of this sensory information in the BLA results in the formation of associations between neutral predictive stimuli and outcomes of positive or negative valence56 via Hebbian mechanisms57-59.”
From Resolving the neural circuits of anxiety (2015) · cites this paper as [56]
In the citing paper
“This interpretation is in part dictated by the individual’s previous experience and includes the assignment of valence to the stimulus via BLA circuits56.”
From Resolving the neural circuits of anxiety (2015) · cites this paper as [56]
In the citing paper
“the valence detection function of BLA projection neurons56 fits within the interpretation circuits described here, helping to determine whether a given stimulus is threatening or appetitive.”
From Resolving the neural circuits of anxiety (2015) · cites this paper as [56]
In the citing paper
“The BLA is critical for associative learning”
From Infraslow histaminergic dynamics govern priming states to gate moment-to-moment memory accessibility (2026) · cites this paper as [30]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Russell, J. A. (1980) · Journal of Personality and Social Psychology · doi:10.1037/h0077714 · Cited by 16,334
LeDoux, J. E. (2000) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.23.1.155 · Cited by 8,444
Fear memories require protein synthesis in the amygdala for reconsolidation after retrieval
Nader, K., Schafe, G. E., & Le Doux, J. E. (2000) · Nature · doi:10.1038/35021052 · Cited by 2,706
Adolphs, R., Tranel, D., Damasio, H., & Damasio, A. (1994) · Nature · doi:10.1038/372669a0 · Cited by 2,360
The role of the amygdala in fear and anxiety
Davis, M. (1992) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.15.030192.002033 · Cited by 2,357
THE AMYGDALA MODULATES THE CONSOLIDATION OF MEMORIES OF EMOTIONALLY AROUSING EXPERIENCES
McGaugh, J. L. (2004) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.27.070203.144157 · Cited by 2,296
THE COMPARATIVE ANATOMY OF THE NERVOUS SYSTEM OF VERTEBRATES INCLUDING MAN
Ariëns, K. C. U., Huber, G. C., & Grosby, E. C. (1936) · The Journal of Nervous and Mental Disease · doi:10.1097/00005053-193611000-00044 · Cited by 2,098
Neurons in medial prefrontal cortex signal memory for fear extinction
Milad, M. R., & Quirk, G. J. (2002) · Nature · doi:10.1038/nature01138 · Cited by 1,836
Phelps, E. A., Delgado, M. R., Nearing, K. I., & LeDoux, J. E. (2004) · Neuron · doi:10.1016/j.neuron.2004.08.042 · Cited by 1,753
Conscious and unconscious emotional learning in the human amygdala
Morris, J. S., Öhman, A., & Dolan, R. J. (1998) · Nature · doi:10.1038/30976 · Cited by 1,665
Flagged first, then by citations
Research works printed but not linked: 1
- Kim, S.-Y. et al. Diverging neural pathways assemble a behavioural state from separable features in anxiety. Nature 496, 219–223 (2013). · DOI · Paper page
Cited by
Sorted by citations
Items 401–500 of 1,002
Baribeau, D. A., Dupuis, A., Paton, T., Scherer, S. W., Schachar, R. J., Arnold, P. D., Szatmári, P., Nicolson, R., Georgiades, S., Crosbie, J., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-10821-0 · Cited by 51
TMEM16A expression in cholinergic neurons of the medial habenula mediates anxiety‐related behaviors
Cho, C., Lee, S.-J., Kim, A., Yarishkin, O. V., Ryoo, K., Lee, Y., Jung, H., Yang, E., Lee, D. Y., Lee, B., et al. (2019) · EMBO Reports · doi:10.15252/embr.201948097 · Cited by 43
“The amygdala, innervated by multiple input pathways, has been established as one of the major regions involved in anxiety [2].”
Quattrini, G., Pievani, M., Jovicich, J., Aiello, M., Bargalló, N., Barkhof, F., Bartrés‐Faz, D., Beltramello, A., Pizzini, F. B., Blin, O., et al. (2020) · NeuroImage · doi:10.1016/j.neuroimage.2020.116932 · Cited by 44
“Within the limbic system, the amygdalar sub-circuit includes the orbitofrontal cortex and the anterior cingulate cortex, and is mainly related to emotional processes (particularly fear-related behavior, such as fear conditioning and recognition of fearful stimuli) and reward-related mechanisms (Benarroch, 2015; Janak…”
BackgroundIdentification of amygdala-expressed genes associated with autism spectrum disorder
Herrero, M. J., Velmeshev, D., Hernandez‐Pineda, D., Sethi, S., Sorrells, S. F., Banerjee, P., Sullivan, C. A. W., Gupta, A. R., Kriegstein, A. R., & Corbin, J. G. (2020) · Molecular Autism · doi:10.1186/s13229-020-00346-1 · Cited by 45
Zhang, X., Feng, C., Pei, L., Zhang, Y.-N., Chen, L., Wei, X., Zhou, J. J., Yong, Y., & Wang, K. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.657507 · Cited by 44
“The amygdaloid complex (also known as the amygdala) is an important part of the limbic system because it is critical in regulating emotion and motivation (Janak and Tye, 2015).”
BackgroundA corticoamygdalar pathway controls reward devaluation and depression using dynamic inhibition code
Yuan, Z., Qi, Z., Wang, R., Cui, Y., An, S., Wu, G., Feng, Q., Lin, R., Dai, R., Li, A., et al. (2023) · Neuron · doi:10.1016/j.neuron.2023.08.022 · Cited by 45
Miedl, S. F., Blechert, J., Klackl, J., Wiggert, N., Reichenberger, J., Derntl, B., & Wilhelm, F. H. (2016) · NeuroImage · doi:10.1016/j.neuroimage.2016.02.027 · Cited by 43
“…to positive and negative facial expressions (Derntl et al., 2009; Fitzgerald et al., 2006; Tettamanti et al., 2012), thereby acting as a relevance detector (Sander et al., 2003) with a relatively close link to overt behavior and psychophysiological responses (for review see Janak and Tye, 2015).”
BackgroundChildhood maltreatment and risk for suicide attempts in major depression: a sex-specific approach
Goldberg, X., Serra-Blasco, M., Vicent-Gil, M., Aguilar, E., Ros, L., Arias, B., Courtet, P., Palao, D. J., & Cardoner, N. (2019) · European Journal of Psychotraumatology · doi:10.1080/20008198.2019.1603557 · Cited by 48
“…differences are evident in these processes, specifically those including the involvement of the amygdala in emotional and behavioural responses (Janak & Tye, 2015) and the presence of sex-hormone receptors (Bender et al., 2017; Engman, Linnman, Van Dijk, & Milad, 2016), which may confer girls…”
BackgroundMechanisms of competitive selection: A canonical neural circuit framework
Mysore, S. P., & Kothari, N. B. (2020) · eLife · doi:10.7554/elife.51473 · Cited by 43
“…Tobler et al., 2009 ; O’Neill and Schultz, 2010 ; Levy and Glimcher, 2012 ; Raghuraman and Padoa-Schioppa, 2014 ; Monosov, 2017 ; Chen and Stuphorn, 2018 ), and stimulus valence ( Paton et al., 2006 ; Belova et al., 2007 ; Morrison and Salzman, 2009 ; Shabel and Janak, 2009 ; Janak and Tye, 2015 ).”
Shi, Y., Wu, X., Zhou, J., Cui, W., Wang, J., Hu, Q., Zhang, S., Han, L., Zhou, M., Luo, J., et al. (2022) · Advanced Science · doi:10.1002/advs.202104112 · Cited by 42
The mouse brain after foot shock in four dimensions: Temporal dynamics at a single-cell resolution
Bonapersona, V., Schuler, H., Damsteegt, R., Adolfs, Y., Pasterkamp, R. J., van den Heuvel, M. P., Joëls, M., & Sarabdjitsingh, R. A. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2114002119 · Cited by 45
“Previous rodent studies have established that even small areas, such as the basolateral amygdala (BLA), have a heterogeneous cellular composition (3) and contribute to a wide array of behaviors (4), presumably linked to long-range connectivity (3).”
Yu, H., Chen, L., Lei, H., Pi, G., Xiong, R., Jiang, T., Wu, D., Sun, F., Gao, Y., Li, Y., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-33139-6 · Cited by 46
Ozdemir, D., Allain, F., Kieffer, B. L., & Darcq, E. (2023) · Neuropharmacology · doi:10.1016/j.neuropharm.2023.109524 · Cited by 45
“Amygdalar circuitries The amygdala is a key brain center involved in mood regulation and negative affect (Janak and Tye, 2015; Phelps and LeDoux, 2005).”
BackgroundWang, H., Wang, Q., Cui, L., Feng, X., Dong, P., Tan, L., Lin, L., Lian, H., Cao, S.-X., Huang, H., et al. (2024) · Nature Neuroscience · doi:10.1038/s41593-023-01562-7 · Cited by 46
Li, D., Li, Y., Zhu, Z.-Y., Zhang, F., Zhao, Q., Jiang, J.-H., Shen, B., Tang, Y., & Xu, G. (2025) · Neuron · doi:10.1016/j.neuron.2025.04.019 · Cited by 42
“The BLA processes inputs from both external and internal sources, transmitting signals to the CeA, 39,40 which evaluates and integrates these inputs to guide behavior and physiological responses.”
Qin, X., Liu, X.-X., Wang, Y., Wang, D., Song, Y., Zou, J., Pan, H., Zhai, X.-Z., Zhang, Y.-M., Zhang, Y.-B., et al. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.119959 · Cited by 46
Emerging role of astrocytes in oxytocin-mediated control of neural circuits and brain functions
Baudon, A., Creusot, E. C., Althammer, F., Schaaf, C. P., & Charlet, A. (2022) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2022.102328 · Cited by 44
“, 2017), which are thought to have antagonistic functions, at least in fear, anxiety (Janak and Tye, 2015) and pain expression (Wilson and Murphy, 2009).”
BackgroundZheng, L., Miao, M., & Gan, Y. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104721 · Cited by 41
Abraham, E., Hendler, T., Zagoory-Sharon, O., & Feldman, R. (2019) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2018.02.001 · Cited by 38
The dynamic nature of fear engrams in the basolateral amygdala
Davis, P. W., & Reijmers, L. G. J. E. (2017) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2017.12.004 · Cited by 43
“The BLA contains a large variety of different interneurons and projection neurons that differ in their synaptic connectivity within BLA microcircuits as well as with other brain regions (Janak and Tye, 2015; Tovote et al., 2015; Orsini and Maren, 2012; Duvarci and Pare, 2014).”
BackgroundInfluentialValence Encoding Signals in the Human Amygdala and the Willingness to Eat
Tiedemann, L. J., Alink, A., Beck, J., Büchel, C., & Brassen, S. (2020) · Journal of Neuroscience · doi:10.1523/jneurosci.2382-19.2020 · Cited by 43
“The amygdala with its reciprocal connections to the sensory, prefrontal, and reward systems (Sah et al., 2003; Janak and Tye, 2015) is a key region in valence assignment (Sergerie et al.”
BackgroundOverview of the central amygdala role in feeding behaviour
Izadi, M. S., & Radahmadi, M. (2021) · British Journal Of Nutrition · doi:10.1017/s0007114521002312 · Cited by 42
“As part of the brain’s limbic system, it is located bilaterally in the medial temporal lobes of the brain(34).”
BackgroundAvoidance of learnt fear: Models, potential mechanisms, and future directions
Wong, A. H. K., Wirth, F. M., & Pittig, A. (2022) · Behaviour Research and Therapy · doi:10.1016/j.brat.2022.104056 · Cited by 43
Crimmins, B. E., Lingawi, N. W., Chieng, B. C. H., Leung, B. K., Maren, S., & Laurent, V. (2022) · Neuropsychopharmacology · doi:10.1038/s41386-022-01427-w · Cited by 41
The interhemispheric amygdala-accumbens circuit encodes negative valence in mice
Tian, Z., Song, J., Zhao, X., Zhou, Y., Chen, X., Le, Q., Wang, F., Ma, L., & Liu, X. (2024) · Science · doi:10.1126/science.adp7520 · Cited by 50
Failing as doorman and disc jockey at the same time: Amygdalar dysfunction in Parkinson's disease
Diederich, N. J., Goldman, J. G., Stebbins, G. T., & Goetz, C. G. (2015) · Movement Disorders · doi:10.1002/mds.26460 · Cited by 41
“The most widely accepted concept proposes a subdivision into two major parts: the large laterobasal amygdalar complex (LBA) composed of the lateral (LA), basal (BA) and basomedial (BM) cell groups and the centromedial complex composed of the corticomedial nuclei (CMA) and the central nuclei (Ce), divided into medial a…”
BackgroundInfluentialCarlisi, C. O., & Robinson, O. J. (2018) · Brain and Neuroscience Advances · doi:10.1177/2398212818774223 · Cited by 48
“Indeed, across a range of paradigms in rodents, the PFC has been shown to play a regulatory role over BLA activation during fear expression, social interaction and anxiety-related behaviours (Bickart et al., 2014; Bremner, 2004; Davis, 1998; Felix-Ortiz et al., 2013; Janak and Tye, 2015; Kling and Steklis, 1976).”
BackgroundBerret, E., Kintscher, M., Palchaudhuri, S., Tang, W., Osypenko, D., Kochubey, O., & Schneggenburger, R. (2019) · Science · doi:10.1126/science.aaw0474 · Cited by 42
RetractedShvachiy, L., Geraldes, V., Amaro-Leal, Â., & Rocha, I. (2020) · Neurotoxicity Research · doi:10.1007/s12640-020-00162-8 · Cited by 41
Long, K. L. P., Chao, L. L., Kazama, Y., An, A., Hu, K. Y., Peretz, L., Muller, D. C. Y., Roan, V. D., Misra, R., Toth, C., et al. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01745-5 · Cited by 41
“These associations are fitting, as the hippocampus has been implicated in approach/ avoidance conflict and anxiety [73–75], while the amygdala and CA hippocampal subregions contribute to associative fear learning and spatial memory, respectively [76, 77].”
BackgroundAdolescence and “Late Blooming” Synapses of the Prefrontal Cortex
Delevich, K., Thomas, A. W., & Wilbrecht, L. (2018) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2018.83.037507 · Cited by 46
Subcortical brain structures and the risk of dementia in the Rotterdam Study
van der Velpen, I. F., Vlasov, V., Evans, T. E., Ikram, M. K., Gutman, B. A., Roshchupkin, G. V., Adams, H. H. H., Vernooij, M. W., & Ikram, M. A. (2022) · Alzheimer s & Dementia · doi:10.1002/alz.12690 · Cited by 40
Neuronal cell types, projections, and spatial organization of the central amygdala
O’Leary, T. P., Kendrick, R. M., Bristow, B. N., Sullivan, K. E., Wang, L., Clements, J., Lemire, A. L., & Cembrowski, M. S. (2022) · iScience · doi:10.1016/j.isci.2022.105497 · Cited by 42
“How a single brain region can support such a diverse repertoire of functions and behaviors remains unknown.(8)”
BackgroundNeural Activity Patterns Underlying Spatial Coding in the Hippocampus
Sosa, M., Gillespie, A. K., & Frank, L. M. (2016) · Current topics in behavioral neurosciences · doi:10.1007/7854_2016_462 · Cited by 43
“CA1 also communicates bidirectionally with the amygdala (Pitkanen et al. 2000; Pikkarainen et al. 1999), which has been long been implicated in emotional forms of learning and conditioned fear memory (Gallagher and Chiba 1996; Paz and Pare 2013; Duvarci and Pare 2014; Janak and Tye 2015).”
BackgroundManuel, A. L., Murray, N. W. G., & Piguet, O. (2019) · Scientific Reports · doi:10.1038/s41598-019-55157-z · Cited by 40
Tesli, N., van der Meer, D., Rokicki, J., Storvestre, G. B., Røsæg, C., Jensen, A., Hjell, G., Bell, C., Fischer-Vieler, T., Tesli, M., et al. (2020) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-020-01098-y · Cited by 40
Li, G., Hu, Y., Zhang, W., Ding, Y., Wang, Y., Wang, J., He, Y., Lv, G., von Deneen, K. M., Zhao, Y., et al. (2020) · Addiction Biology · doi:10.1111/adb.12974 · Cited by 40
Cortico-subcortical interactions in overlapping communities of edge functional connectivity
Chumin, E. J., Faskowitz, J., Esfahlani, F. Z., Jo, Y., Merritt, H., Tanner, J., Cutts, S. A., Pope, M., Betzel, R. F., & Sporns, O. (2022) · NeuroImage · doi:10.1016/j.neuroimage.2022.118971 · Cited by 44
“other subcortical structures (thalamus, amygdala, hippocampus) have roles in emotional, memory, and sensorimotor functions through various subcortical and cortico-subcortical circuits (Child and Benarroch, 2013; Choi et al., 2017; Janak and Tye, 2015; Nakajima and Halassa, 2017; Sherman, 2017).”
BackgroundHigher-Order Inputs Involved in Appetite Control
Azevedo, E. P., Ivan, V. J., Friedman, J. M., & Stern, S. A. (2021) · Biological Psychiatry · doi:10.1016/j.biopsych.2021.07.015 · Cited by 43
Soumiya, H., Godai, A., Araiso, H., Mori, S., Furukawa, S., & Fukumitsu, H. (2016) · PLoS ONE · doi:10.1371/journal.pone.0158583 · Cited by 39
Guo, C., Moses‐Kolko, E. L., Phillips, M. L., Swain, J. E., & Hipwell, A. E. (2018) · Cognitive Affective & Behavioral Neuroscience · doi:10.3758/s13415-017-0516-x · Cited by 41
“…supports the crucial role of amygdala related FC in maternal caregiving (Atzil et al., 2011), social affiliation (Atzil et al., 2011; Bickart, Dickerson, & Barrett, 2014; Porges, 2007), and also the expression of anxiety symptoms (Janak & Tye, 2015; M. J. Kim et al., 2011; Sylvester et al., 2012).”
BackgroundNeural and Endocrine Correlates of Early Life Abuse in Youth With Depression and Obesity
Sun, K., Watson, K. T., Angal, S., Bakkila, B. F., Gorelik, A. J., Leslie, S. M., Rasgon, N., & Singh, M. K. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00721 · Cited by 39
“We observed less negative amygdala-precuneus connectivity in high abuse compared to low abuse youth with depression and obesity, which may result in impaired emotion processing and regulation (61, 62), problems with self-reflection (63, 64), and lower self-esteem in these youth (65).”
BackgroundZhang, R., Zhang, L., Wei, S., Wang, P., Jiang, X., Tang, Y., & Wang, F. (2021) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2020.585664 · Cited by 42
“The amygdala, which consists of paired structures located in each hemisphere of the brain, is an important region associated with emotional and cognitive processing (Strobel et al., 2014; Janak and Tye, 2015; Yang and Wang, 2017).”
BackgroundWu, X., Ding, Z., Fan, T., Wang, K., Li, S., Zhao, J., & Zhu, W. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.943067 · Cited by 41
“There are as high as 80% of neurons in the BLA are glutamatergic, and the high local concentrations of excitatory neurotransmitter glutamate are associated with impaired BBB (Sharp et al., 2003; De Bock et al., 2013; Janak and Tye, 2015; Vazana et al., 2016).”
BackgroundFunctional connectivity of amygdala subnuclei in PTSD: a narrative review
Haris, E. M., Bryant, R. A., Williamson, T., & Korgaonkar, M. S. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02291-w · Cited by 38
“Yet this disregards its composition as a region comprised of multiple structurally and functionally heterogenous subnuclei across species [11, 12].”
BackgroundJackson, A. D., Cohen, J. L., Phensy, A. J., Chang, E. F., Dawes, H. E., & Sohal, V. S. (2024) · Neuron · doi:10.1016/j.neuron.2023.12.017 · Cited by 39
“13,14 18 Although these studies high-light a role for vHC-BLA interactions in anxiety, little is known about the specific underlying neural activity patterns.”
A neural mechanism for learning from delayed postingestive feedback
Zimmerman, C. A., Bolkan, S. S., Pan-Vazquez, A., Wu, B., Keppler, E., Meares-Garcia, J. B., Guthman, E. M., Fetcho, R. N., McMannon, B., Lee, J., et al. (2025) · Nature · doi:10.1038/s41586-025-08828-z · Cited by 49
Advances in understanding meso‐cortico‐limbic‐striatal systems mediating risky reward seeking
Piantadosi, P. T., Halladay, L. R., Radke, A. K., & Holmes, A. (2021) · Journal of Neurochemistry · doi:10.1111/jnc.15342 · Cited by 45
“…distinct projection populations that contribute differently to positive and negative valence behaviors exist in the BLA (Beyeler et al., 2016, 2018; Kim, Zhang, et al., 2017; Shen et al., 2019) and other amygdala subregions (Hardaway et al., 2019; Janak & Tye, 2015; Miller et al., 2019).”
BackgroundAcoustic developmental programming: a mechanistic and evolutionary framework
Mariette, M. M., Clayton, D. F., & Buchanan, K. L. (2021) · Trends in Ecology & Evolution · doi:10.1016/j.tree.2021.04.007 · Cited by 40
Instrumental aversion coding in the basolateral amygdala and its reversion by a benzodiazepine
Jean-Richard-dit-Bressel, P., Tran, J., Didachos, A., & McNally, G. P. (2021) · Neuropsychopharmacology · doi:10.1038/s41386-021-01176-2 · Cited by 41
Ding, X., Lin, Y., Chen, C., Yan, B., Liu, Q., Zheng, H. W., Wu, Y., & Zhou, C. (2023) · Biological Psychiatry · doi:10.1016/j.biopsych.2023.03.015 · Cited by 38
Liang, J., Chen, L., Li, Y., Chen, Y., Yuan, L., Qiu, Y., Ma, S., Fan, F., & Cheng, Y. (2024) · Schizophrenia Bulletin · doi:10.1093/schbul/sbae063 · Cited by 42
Reward Network Immediate Early Gene Expression in Mood Disorders
Manning, C., WILLIAMS, E. S., & Robison, A. J. (2017) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2017.00077 · Cited by 37
“While general BLA activity and BLA projections to many other brain regions regulate fear-related learning and behavior, glutamatergic inputs from BLA onto NAc MSNs increases reward seeking and supports positive reinforcement (Ambroggi et al., 2008; Stuber et al., 2011; Janak and Tye, 2015).”
BackgroundSerine Racemase and D-serine in the Amygdala Are Dynamically Involved in Fear Learning
Balu, D. T., Presti, K. T., Huang, C. C., Muszynski, K., Radzishevsky, I. S., Wolosker, H., Guffanti, G., Ressler, K. J., & Coyle, J. T. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.08.012 · Cited by 38
“There are at least two subpopulations of neurons within the CeL that express distinct markers and have opposing functions (14, 45, 46).”
BackgroundIncreased Grik4 Gene Dosage Causes Imbalanced Circuit Output and Human Disease-Related Behaviors
Arora, V., Pecoraro, V., Aller, M. I., Román, C., Paternain, A. V., & Lerma, J. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.05.086 · Cited by 36
Llorente, R., Marraudino, M., Carrillo, B., Bonaldo, B., Simon‐Areces, J., Abellanas-Pérez, P., Rivero-Aguilar, M., Fernández‐García, J. M., Pinos, H., García‐Segura, L. M., et al. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00537 · Cited by 38
“The hippocampus and the amygdala are two anatomically and functionally interconnected brain regions that participate in the regulation of stress responses (1, 2), fear (3–5), emotions (6–8), learning (9), and memory (8, 10).”
BackgroundValence processing in the PFC: Reconciling circuit-level and systems-level views
Coley, A. A., Padilla-Coreano, N., Patel, R. R., & Tye, K. M. (2021) · International review of neurobiology · doi:10.1016/bs.irn.2020.12.002 · Cited by 39
Self-citationNovel Perspectives on the Development of the Amygdala in Rodents
Aerts, T., & Seuntjens, E. (2021) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2021.786679 · Cited by 36
Methylglyoxal in the Brain: From Glycolytic Metabolite to Signalling Molecule
Yang, Z., Zhang, W., Han, L., & Cai, S. (2022) · Molecules · doi:10.3390/molecules27227905 · Cited by 36
“Sugars are produced from metabolised glucose and then react covalently with proteins to pr duce AGEs, which can impact protein function [23].”
Cerebellar contribution to the regulation of defensive states
da Silva, G. N., Seiffert, N., & Tovote, P. (2023) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2023.1160083 · Cited by 37
“The amygdala, with its lateral (LA), basolateral (BLA), and central nuclei (CEA) has long been known as a central player in innate and learned defensiveness, and aversive emotions such as fear and anxiety.”
BackgroundInfluentialAn active inference perspective for the amygdala complex
Sladky, R., Kargl, D., Haubensak, W. E., & Lamm, C. (2023) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2023.11.004 · Cited by 41
“The amygdala comprises several smaller subnuclei [10].”
Enhanced Pavlovian aversive conditioning to positive emotional stimuli.
Stussi, Y., Pourtois, G., & Sander, D. (2018) · Journal of Experimental Psychology General · doi:10.1037/xge0000424 · Cited by 41
“…and positive stimulus’ values has been shown to rely on overlapping brain structures (e.g., Canli, Sivers, Whitfield, Gotlib, & Gabrieli, 2002; Janak & Tye, 2015; Jin, Zelano, Got-tfried, & Mohanty, 2015; Namburi et al., 2015; Paton, Belova, Morrison, & Salzman, 2006; Seymour, Daw, Dayan,…”
A Non-Canonical Cortico-Amygdala Inhibitory Loop
Bertero, A., Feyen, P., Zurita, H., & Apicella, A. J. (2019) · Journal of Neuroscience · doi:10.1523/jneurosci.1515-19.2019 · Cited by 38
“Previous studies have extensively characterized the neuronal circuits underlying fear conditioning (Janak and Tye, 2015).”
BackgroundFear-Related Signals in the Primary Visual Cortex
Li, Z., Yan, A., Guo, K., & Li, W. (2019) · Current Biology · doi:10.1016/j.cub.2019.09.063 · Cited by 36
“The amygdala, which is indispensable in fear learning [21], is directly connected with visual areas, including V1, forming a closed loop [22, 23].”
Threat imminence dictates the role of the bed nucleus of the stria terminalis in contextual fear
Goode, T. D., Acca, G. M., & Maren, S. (2019) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2019.107116 · Cited by 36
Han, S. D., Lamar, M., Fleischman, D. A., Kim, N., Bennett, D. A., Lewis, T. T., Arfanakis, K., & Barnes, L. L. (2020) · Brain Imaging and Behavior · doi:10.1007/s11682-020-00365-9 · Cited by 38
Emotional behavior and brain anatomy of the mdx52 mouse model of Duchenne muscular dystrophy
Saoudi, A., Zarrouki, F., Sebrié, C., Izabelle, C., Goyenvalle, A., & Vaillend, C. (2021) · Disease Models & Mechanisms · doi:10.1242/dmm.049028 · Cited by 38
“This might include alteration of sensory inputs processing, impairment of CSUS association by neurons of the lateral amygdala, altered specificity of the activation of BLA fear neurons by the lateral amyglada and/or impaired plasticity of BLA networks (Herry et al., 2008; Janak and Tye, 2015; Wallace and Rosen, 2001).”
BackgroundMineur, Y. S., Garcia‐Rivas, V., Thomas, M. A., Soares, A. R., McKee, S. A., & Picciotto, M. R. (2022) · Psychopharmacology · doi:10.1007/s00213-022-06120-w · Cited by 34
“Importantly, the basolateral amygdala (BLA) underlies the complex control of behaviors that are related to both aversive (stress) and rewarding (acute alcohol intake) stimuli (Baxter and Murray 2002; Janak and Tye 2015; Crouse et al.”
BackgroundNeural Control of Sexually Dimorphic Social Behavior: Connecting Development to Adulthood
McCarthy, M. M. (2023) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-121522-110856 · Cited by 40
The emotion paradox in the aging body and brain
Mather, M. (2024) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.15138 · Cited by 38
The human medial amygdala: structure, diversity, and complexity of dendritic spines
Dall’Oglio, A., Dutra, A. C. L., Moreira, J. E., & Rasia‐Filho, A. A. (2015) · Journal of Anatomy · doi:10.1111/joa.12358 · Cited by 37
“…in the subcortical part of the dorsomedial pole of the tempo- ral lobe, rostral to the hippocampus, and close to the infe- rior margins of the claustrum, putamen, and globus pallidus (Brodal, 1981; Everitt, 1995; de Olmos, 2004; Yilmazer-Hanke, 2012; Dall’Oglio et al. 2013; Janak & Tye, 2015).”
BackgroundLooking at the face and seeing the whole body. Neural basis of combined face and body expressions
Solanas, M. P., Zhan, M., Vaessen, M. J., Hortensius, R., Engelen, T., & de Gelder, B. (2017) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsx130 · Cited by 38
“One possible explanation for this effect, as previously suggested in the literature (Rudrauf et al., 2008; Janak and Tye, 2015; de Borst and de Gelder, 2016), could be that conflicting information leads to concurrent reciprocal inhibition of subcortical structures, like the amygdala, consequently…”
BackgroundPatel, A. G., Biso, G. M. N. R., & Fowler, J. B. (2019) · StatPearls · Cited by 36
Miro1-dependent mitochondrial dynamics in parvalbumin interneurons
Kontou, G., Antonoudiou, P., Podpolny, M., Arancibia‐Cárcamo, I. L., Higgs, N., Szulc, B. R., López‐Doménech, G., Salinas, P. C., Mann, E. O., & Kittler, J. T. (2021) · eLife · doi:10.7554/elife.65215 · Cited by 37
Roseboom, P. H., Mueller, S. A. L., Oler, J. A., Fox, A. S., Riedel, M. K., Elam, V. R., Olsen, M. E., Gomez, J. L., Boehm, M. A., DiFilippo, A. H., et al. (2021) · Molecular Therapy · doi:10.1016/j.ymthe.2021.04.021 · Cited by 36
“Many rodent studies have demonstrated 272 that these amygdala subregions are involved in modulating anxiety-related behavior.(60-67) For 273”
BackgroundRodier, J.-A., Mclain, C., Minerva, A. R., Rashford, R. L., Bennett, S. N., Rogers, F. D., & Peña, C. J. (2023) · Journal of Neuroscience · doi:10.1523/jneurosci.0016-23.2023 · Cited by 40
Brain activation elicited by acute stress: An ALE meta-analysis
Qiu, Y., Fan, Z., Zhong, M., Yang, J., Wu, K., Hu, H., Zhang, R., Guo, Y. Q., Lee, T. M. C., & Huang, R. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.11.020 · Cited by 37
Manohar, S., Chen, G., Ding, D., Liu, L., Wang, J., Chen, Y., Chen, L., & Salvi, R. (2022) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2022.871223 · Cited by 37
Fear extinction relies on ventral hippocampal safety codes shaped by the amygdala
Nguyen, R., Koukoutselos, K., Forro, T., & Ciocchi, S. (2023) · Science Advances · doi:10.1126/sciadv.adg4881 · Cited by 36
“Furthermore, Ext-TRAPed mice showed higher tdTomato labeling in the amygdala ( 43 ) and paraventricular thalamus ( 44 ) — regions linked to emotional valence, as well as the claustrum that may support attentional processes ( 45 ) and the nucleus reuniens that plays a role in spatial navigation and…”
BackgroundSun, X., Le, L., Song, Y., Wu, T., Zheng, T., Hao, J., Cao, J., & Gao, C. (2022) · Cell Reports · doi:10.1016/j.celrep.2023.112719 · Cited by 35
Fear and Reward Circuit Alterations in Pediatric CRPS
Simons, L. E., Erpelding, N., Hernandez, J. M., Serrano, P. V., Zhang, K., Lebel, A., Sethna, N. F., Berde, C. B., Prabhu, S. P., Becerra, L. R., et al. (2016) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2015.00703 · Cited by 35
Evidence for GABA‐A receptor dysregulation in gambling disorder: correlation with impulsivity
Mick, I., Ramos, A. C., Myers, J., Stokes, P. R. A., Chandrasekera, S., Erritzøe, D., Méndez, M. A., Gunn, R. N., Rabiner, E. A., Searle, G. E., et al. (2016) · Addiction Biology · doi:10.1111/adb.12457 · Cited by 35
“The amygdala is a key region involved in a number of processes such as emotional processing, fear, reward valence and neuropsychiatric disorders including addiction and anxiety (Elman et al. 2012; Janak and Tye 2015; van Holst et al. 2012).”
Time‐dependent neuronal changes associated with craving in opioid dependence: an fMRI study
Murphy, A., Lubman, D. I., McKie, S., Bijral, P., Peters, L., Faiz, Q., Holmes, S. E., Anderson, I. M., Deakin, J. F. W., & Elliott, R. (2017) · Addiction Biology · doi:10.1111/adb.12554 · Cited by 35
“This finding is in agreement with evidence demonstrating the amygdala to be important for Pavlovian-conditioned behaviour and motivation (Janak & Tye 2015).”
ResultImplicit aversive memory under anaesthesia in animal models: a narrative review
Samuel, N., Taub, A. H., Paz, R., & Raz, A. (2018) · British Journal of Anaesthesia · doi:10.1016/j.bja.2018.05.046 · Cited by 35
The role of vasopressin in olfactory and visual processing
Wacker, D. W., & Ludwig, M. (2018) · Cell and Tissue Research · doi:10.1007/s00441-018-2867-1 · Cited by 37
“The amygdala and related bed nucleus of the stria terminalis (BSt) are multi-faceted interconnected structures with a number of reciprocal connections with olfactory processing areas and other brain regions (Janak and Tye 2015; Pitkanen 2000; Swanson and Petrovich 1998).”
BackgroundCorticolimbic Mechanisms of Behavioral Inhibition under Threat of Punishment
Verharen, J. P. H., van den Heuvel, M. W., Luijendijk, M. C. M., Vanderschuren, L. J. M. J., & Adan, R. A. H. (2019) · Journal of Neuroscience · doi:10.1523/jneurosci.2814-18.2019 · Cited by 34
“Adaptive inhibition of behavior is thought to rely on functional activity in a network of regions including the prefrontal cortex (PFC), ventral striatum, and amygdala, which has been implicated in the processing of emotionally relevant cues, the selection of appropriate behavioral strategies and the transmission of s…”
BackgroundResultBas‐Hoogendam, J. M., van Steenbergen, H., van der Wee, N. J. A., & Westenberg, P. M. (2020) · NeuroImage Clinical · doi:10.1016/j.nicl.2020.102247 · Cited by 37
Beneath the surface: hyper-connectivity between caudate and salience regions in ADHD fMRI at rest
Damiani, S., Tarchi, L., Scalabrini, A., Marini, S., Provenzani, U., Rocchetti, M., Oliva, F., & Politi, P. (2020) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-020-01545-0 · Cited by 35
Zhang, P., Wu, G., Yu, F., Liu, Y., Li, M., Zheng, W., Ding, H., Li, X.-S., Wang, H., Jin, M., et al. (2020) · Obesity · doi:10.1002/oby.22839 · Cited by 36
“Specifically, abnormal functional alterations in amygdala would impair the ability of responding to cues in the face of changing reward value, including food-related rewards (41).”
BackgroundNonhuman Primate Models to Explore Mechanisms Underlying Early-Life Temperamental Anxiety
Kenwood, M. M., & Kalin, N. H. (2020) · Biological Psychiatry · doi:10.1016/j.biopsych.2020.08.028 · Cited by 35
“This simplified circuit diagram depicts general organizational principles that have been characterized in rodent models (58,90,91,96).”
BackgroundYu, H., Villanueva, N., Bittar, T. P., Arsenault, E., Labonté, B., & Huan, T. (2020) · Analytica Chimica Acta · doi:10.1016/j.aca.2020.09.051 · Cited by 36
The Raphe Dopamine System: Roles in Salience Encoding, Memory Expression, and Addiction
Lin, R., Liang, J., & Luo, M. (2021) · Trends in Neurosciences · doi:10.1016/j.tins.2021.01.002 · Cited by 36
Phillips, R. D., De Bellis, M. D., Brumback, T., Clausen, A. N., Clarke-Rubright, E. K., Haswell, C. C., & Morey, R. A. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01275-0 · Cited by 35
Long-Range GABAergic Projections of Cortical Origin in Brain Function
Urrutia-Piñones, J., Morales-Moraga, C., Sanguinetti, N. K., Escobar, A. P., & Chiu, C. Q. (2022) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2022.841869 · Cited by 36
Limoges, A., Yarur, H. E., & Tejeda, H. A. (2022) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2022.963691 · Cited by 35
“Outputs of the BLA include the CeA, BNST, lateral hypothalamus (LH), nucleus accumbens, ventral tegmental area, and the BLA’s reciprocal connections with the mPFC and ventral hippocampus (Pape and Pare, 2010; Janak and Tye, 2015; Hintiryan et al., 2021; Murray and Fellows, 2022).”
BackgroundCustomizable, wireless and implantable neural probe design and fabrication via 3D printing
Parker, K. E., Lee, J., Kim, J. R., Kawakami, C., Kim, C. Y., Qazi, R., Jang, K., Jeong, J., & McCall, J. G. (2022) · Nature Protocols · doi:10.1038/s41596-022-00758-8 · Cited by 36
“This protocol comprises three procedures: (1) probe fabrication, (2) wireless module preparation and (3) implantation for in vivo assays.”
MethodNielsen, B., Rampin, O., Meunier, N., & Bombail, V. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00226 · Cited by 33
“These odors are referred to as semiochemicals (Law and Regnier, 1971; Regnier, 1971), and consist of two major groups: pheromones [Karlson and Lüscher, 1959a; originally named ectohormones by Bethe (1932)] for intraspecific interactions, and allelochemics (Whittaker, 1970) for interactions between organisms of differe…”
BackgroundBallerini, A., Tondelli, M., Talami, F., Molinari, M. A., Micalizzi, E., Giovannini, G., Turchi, G., Malagoli, M., Genovese, M., Meletti, S., et al. (2022) · Brain Communications · doi:10.1093/braincomms/fcac225 · Cited by 34
“13 Due to the small size of the amygdala, no prior studies focused on changes of amygdala subnuclei in patients with TLE.”
Stolicyn, A., Lyall, L. M., Lyall, D. M., Høier, N. K., Adams, M. J., Shen, X., Cole, J. H., McIntosh, A. M., Whalley, H. C., & Smıth, D. J. (2023) · SLEEP · doi:10.1093/sleep/zsad274 · Cited by 36
“Finally, the amygdala has critical roles in emotion and motivation [81], and higher amygdala volume has been identified in bipolar disorder [82], as well as genetic variants associated with risk for bipolar disorder [83].”
BackgroundDeconstructing the neural circuit underlying social hierarchy in mice
Xin, Q., Zheng, D., Zhou, T., Xu, J., Ni, Z., & Hu, H. (2024) · Neuron · doi:10.1016/j.neuron.2024.11.007 · Cited by 39
Metadata
- Authors
- Janak, P. H., & Tye, K. M.
- Affiliations
- Johns Hopkins University (US)
- Massachusetts Institute of Technology (US)
- Corresponding author
- Janak, Patricia H.
- Tye, Kay M.
- Venue
- Nature
- Published
- 2015-01-14
- Volume
- 517
- Issue
- 7534
- Pages
- 284-292
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC4565157
- OpenAlex
- W1989982790
- Cited by
- 2,011
- References
- 126
- Citations by year
- 2026: 149 · 2025: 193 · 2024: 198 · 2023: 210 · 2022: 207 · 2021: 234 · 2020: 225 · 2019: 172 · 2018: 132 · 2017: 119 · 2016: 114 · 2015: 56
- FWCI
- 13.69
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- DSpace@MIT (Massachusetts Institute of Technology) (submittedVersion, cc-by-nc-sa)
- PMC
- Funders
- New York Stem Cell Foundation
- JPB Foundation
- National Institutes of Health
- National Institute on Alcohol Abuse and Alcoholism (R01AA014925, AA17072, AA014925, P50AA017072, R01AA016835)
- National Institute of Mental Health (R01MH102441, MH102441, R37MH102441)
- National Institute on Drug Abuse (DA015096, R01DA015096, R01DA035943)
- National Institute of Diabetes and Digestive and Kidney Diseases (DP2DK102256)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- amygdala, neural circuits, emotions, motivation, fear, reward, behavioural function, structural connectivity, causal manipulation
- MeSH terms
- Amygdala, Animals, Behavior, Biological Evolution, Fear, Humans, Memory, Neural Pathways, Reward
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
