The DOI matches its Crossref record; 126 of the 126 references it cites were found in a registry or an index.
From circuits to behaviour in the amygdala
Open accessAbstract
The amygdala has long been associated with emotion and motivation, playing an essential part in processing both fearful and rewarding environmental stimuli. How can a single structure be crucial for such different functions? With recent technological advances that allow for causal investigations of specific neural circuit elements, we can now begin to map the complex anatomical connections of the amygdala onto behavioural function. Understanding how the amygdala contributes to a wide array of behaviours requires the study of distinct amygdala circuits.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“More recently, more in-depth research has illustrated that alterations in the HPA axis have been associated with the process of dealing with stress, especially toxic stress-induced negative health outcomes (83).”
From Epigenetic Modifications in Stress Response Genes Associated With Childhood Trauma (2019) · cites this paper as [83]
Experimental — accuracy not yet measuredIn the citing paper
“A growing appreciation for the complexity of the amygdala complex has resulted in a more nuanced understanding of this region’s role in fear learning, appetitive learning, and value encoding (Janak and Tye, 2015), and it is clear that the amygdala promotes adaptive behavioral responses to both positive and negative environmental stimuli.”
From A framework for understanding the emerging role of corticolimbic-ventral striatal networks in OCD-associated repetitive behaviors (2015) · cites this paper as Janak and Tye, 2015
In the citing paper
“In addition to a role in fear and threat conditioning, the amygdala also regulates anxiety.”
From A framework for understanding the emerging role of corticolimbic-ventral striatal networks in OCD-associated repetitive behaviors (2015) · cites this paper as Janak and Tye, 2015
In the citing paper
“Since the amygdala is central to processing these forms of information (Janak and Tye, 2015), aberrant communication of anxiety-related information from amygdala to VS could mediate anxiety-driven compulsive behavior.”
From A framework for understanding the emerging role of corticolimbic-ventral striatal networks in OCD-associated repetitive behaviors (2015) · cites this paper as Janak and Tye, 2015
In the citing paper
“The BNST and the CeA have been implicated in diverse behavioral functions (Davis et al., 2010, Janak and Tye, 2015, Kim et al., 2013)”
From Dorsal raphe dopamine neurons represent the experience of social isolation (2016) · cites this paper as Janak and Tye, 2015
In the citing paper
“In particular, given its access to primary sensory information, the CeA could orchestrate appropriate behavioral responses to salient stimuli with different valences [88,93].”
From Oxytocin Signaling in the Central Amygdala Modulates Emotion Discrimination in Mice (2019) · cites this paper as [93]
In the citing paper
“Processing of this sensory information in the BLA results in the formation of associations between neutral predictive stimuli and outcomes of positive or negative valence56 via Hebbian mechanisms57-59.”
From Resolving the neural circuits of anxiety (2015) · cites this paper as [56]
In the citing paper
“This interpretation is in part dictated by the individual’s previous experience and includes the assignment of valence to the stimulus via BLA circuits56.”
From Resolving the neural circuits of anxiety (2015) · cites this paper as [56]
In the citing paper
“the valence detection function of BLA projection neurons56 fits within the interpretation circuits described here, helping to determine whether a given stimulus is threatening or appetitive.”
From Resolving the neural circuits of anxiety (2015) · cites this paper as [56]
In the citing paper
“The BLA is critical for associative learning”
From Infraslow histaminergic dynamics govern priming states to gate moment-to-moment memory accessibility (2026) · cites this paper as [30]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Russell, J. A. (1980) · Journal of Personality and Social Psychology · doi:10.1037/h0077714 · Cited by 16,334
LeDoux, J. E. (2000) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.23.1.155 · Cited by 8,444
Fear memories require protein synthesis in the amygdala for reconsolidation after retrieval
Nader, K., Schafe, G. E., & Le Doux, J. E. (2000) · Nature · doi:10.1038/35021052 · Cited by 2,706
Adolphs, R., Tranel, D., Damasio, H., & Damasio, A. (1994) · Nature · doi:10.1038/372669a0 · Cited by 2,360
The role of the amygdala in fear and anxiety
Davis, M. (1992) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.15.030192.002033 · Cited by 2,357
THE AMYGDALA MODULATES THE CONSOLIDATION OF MEMORIES OF EMOTIONALLY AROUSING EXPERIENCES
McGaugh, J. L. (2004) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.27.070203.144157 · Cited by 2,296
THE COMPARATIVE ANATOMY OF THE NERVOUS SYSTEM OF VERTEBRATES INCLUDING MAN
Ariëns, K. C. U., Huber, G. C., & Grosby, E. C. (1936) · The Journal of Nervous and Mental Disease · doi:10.1097/00005053-193611000-00044 · Cited by 2,098
Neurons in medial prefrontal cortex signal memory for fear extinction
Milad, M. R., & Quirk, G. J. (2002) · Nature · doi:10.1038/nature01138 · Cited by 1,836
Phelps, E. A., Delgado, M. R., Nearing, K. I., & LeDoux, J. E. (2004) · Neuron · doi:10.1016/j.neuron.2004.08.042 · Cited by 1,753
Conscious and unconscious emotional learning in the human amygdala
Morris, J. S., Öhman, A., & Dolan, R. J. (1998) · Nature · doi:10.1038/30976 · Cited by 1,665
Research works printed but not linked: 1
- Kim, S.-Y. et al. Diverging neural pathways assemble a behavioural state from separable features in anxiety. Nature 496, 219–223 (2013). · DOI · Paper page
Cited by
Sorted by citations
Items 501–600 of 1,002
Amygdala and Emotion: The Bright Side of It
Weymar, M., & Schwabe, L. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00224 · Cited by 41
“Especially, pleasant cues (e.g., Sabatinelli et al., 2007; Costa et al., 2010; Janak and Tye, 2015) have been shown to activate a neural circuit, including the amygdala, medial prefrontal cortex and the nucleus accumbens, that contributes more to reward-seeking behavior (e.g., Russo and Nestler,…”
BackgroundInfluentialHeitmann, C. Y., Feldker, K., Neumeister, P., Brinkmann, L., Schrammen, E., Zwitserlood, P., & Straube, T. (2017) · NeuroImage Clinical · doi:10.1016/j.nicl.2017.01.020 · Cited by 34
“Whole-brain analysis revealed additional activations in temporal lobe (BA13) and parahippocampal gyrus.”
BackgroundMorphological and physiological properties of CCK/CB1R-expressing interneurons in the basal amygdala
Rovira-Esteban, L., Péterfi, Z., Vikór, A., Máté, Z., Szabó, G., & Hájos, N. (2017) · Brain Structure and Function · doi:10.1007/s00429-017-1417-z · Cited by 34
“The amygdala is a complex structure that plays an essential role in several higher order cognitive functions, including fear memory processes, decision making, and social interactions (Davis 1992; LeDoux 2000; Janak and Tye 2015).”
BackgroundOn the Origins of Adaptive Behavioral Complexity: Developmental Channeling of Structural Trade-offs
Duckworth, R. A., Potticary, A. L., & Badyaev, A. V. (2017) · Advances in the study of behavior · doi:10.1016/bs.asb.2017.10.001 · Cited by 32
“For example, the amygdala mediates value 8 Ren ee A. Duckworth et al. judgments of external stimuli (Janak & Tye, 2015), the hypothalamus mediates reactions to stress and can impair performance in the prefrontal cortex (specifically in relation to executive functions; Phelps, Lempert, &…”
BackgroundKerem, L., Hadjikhani, N. K., Holsen, L. M., Lawson, E. A., & Plessow, F. (2019) · International Journal of Obesity · doi:10.1038/s41366-019-0489-7 · Cited by 35
“The amygdala, a brain region involved in salience and stimulus-reward learning (68) was also found in our study to have attenuated functional connectivity with the VTA following the administration of oxytocin.”
ResultMéquinion, M., Foldi, C. J., & Andrews, Z. B. (2020) · Frontiers in Nutrition · doi:10.3389/fnut.2019.00190 · Cited by 34
“One important regionmay be the amygdala given its roles in emotional learning, cue-predicted learning, anxiety, reward processing, and motivation (145).”
BackgroundZhou, C., Wu, Y., Ding, X., Shi, N., Cai, Y., & Pan, Z. Z. (2020) · Journal of Neuroscience · doi:10.1523/jneurosci.1259-19.2020 · Cited by 35
“…SIRT2, and SIRT6 in the central nucleus of the amygdala (CeA), a key brain structure that regulates emotion-related behaviors (Gilpin et al., 2015; Janak and Tye, 2015; Neugebauer, 2015; Thompson and Neugebauer, 2017; Babaev et al., 2018), in the development of chronic pain-induced emotional…”
BackgroundBrehl, A.-K., Kohn, N., Schene, A. H., & Fernández, G. (2020) · Psychological Medicine · doi:10.1017/s0033291720000410 · Cited by 39
“In order to adapt behavioural responses adequately, information regarding positive or negative valence of sensory stimuli is (re)transmitted from the basolateral amygdala to diverse cortical regions, especially the midline and orbital prefrontal cortices, for further processing (Janak & Tye, 2015).”
BackgroundUnrelenting Fear Under Stress: Neural Circuits and Mechanisms for the Immediate Extinction Deficit
Maren, S. (2022) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2022.888461 · Cited by 37
Chen, L., Nagaraja, C., Daniels, S. R., Fisk, Z. A., Dvorak, R., Meyerdirk, L. K., Steiner, J. A., Galvis, M. L. E., Henderson, M. X., Rousseaux, M. W. C., et al. (2022) · eLife · doi:10.7554/elife.78055 · Cited by 33
“The amygdala is a key limbic structure for emotion regulation (Janak and Tye, 2015).”
BackgroundBarroca, N. C. B., Santa, G. D., Suchecki, D., Garcia‐Cairasco, N., & Umeoka, E. H. D. L. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104771 · Cited by 38
The hippocampus associated GABAergic neural network impairment in early-stage of Alzheimer's disease
Tang, Y., Yan, Y., Mao, J., Ni, J., & Qing, H. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.101865 · Cited by 34
Mesial temporal lobe epilepsy diminishes functional connectivity during emotion perception
Steiger, B. K., Muller, A. M., Spirig, E., Toller, G., & Jokeit, H. (2017) · Epilepsy Research · doi:10.1016/j.eplepsyres.2017.05.004 · Cited by 35
Yeh, Y., Lin, C.-W., Hsu, W.-C., Kuo, W., & Chan, Y. (2015) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2015.05.010 · Cited by 38
“With regard to emotions, the amygdala has been regarded as an essential part in processing both fearful and rewarding environmental stimuli (Janak and Tye, 2015).”
BackgroundBidirectional Influence of Limbic GIRK Channel Activation on Innate Avoidance Behavior
Vo, B. N., Marron Fernandez de Velasco, E., Rose, T. R., Oberle, H., Luo, H., Hopkins, C. R., & Wickman, K. (2021) · The Journal of Neuroscience · doi:10.1523/jneurosci.2787-20.2021 · Cited by 33
“1I,J), which shares reciprocal connections with the vHPC and other brain regions implicated in anxiety and avoidance behavior (Calhoon and Tye, 2015; Janak and Tye, 2015). c-Fos labeling in the lateral (LA) subregion of the BLA complex was not significantly impacted by EPM exposure (p = 0.2468;…”
BackgroundInfluentialA revisit of the amygdala theory of autism: Twenty years after
Wang, S., & Li, X. (2023) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2023.108519 · Cited by 38
Peng, X., Mao, Y., Tai, Y., Luo, B., Dai, Q., Wang, X., Wang, H., Liang, Y., Guan, R., Liu, C., et al. (2023) · Environmental Health Perspectives · doi:10.1289/ehp12532 · Cited by 36
“23,56,57 The amygdala circuitry that contributes to associative auditory fear learning has been extensively investigated, 25,55,58 – 62 although to date no studies have examined the involvement of these circuits in noise-evoked anxiety.”
Zhang, Z.-Q., Li, J., Ge, S.-T., Ma, T., Li, F., Junliang, L., Si, S., Cui, Z., Jin, Y., & Jin, X.-H. (2024) · Frontiers in Public Health · doi:10.3389/fpubh.2023.1281689 · Cited by 34
Fear Erasure Facilitated by Immature Inhibitory Neuron Transplantation
Yang, W., Liu, T., Cao, J.-W., Chen, X.-F., Liu, X., Wang, M., Su, X., Zhang, S., Qiu, B., Hu, W., et al. (2016) · Neuron · doi:10.1016/j.neuron.2016.11.018 · Cited by 33
“Based on current knowledge of the overall function and architecture of BLA and CeA microcircuits (Duvarci and Pare, 2014; Janak and Tye, 2015), we focused on circuitry characterization in BLA.”
MethodFrom Architecture to Evolution: Multisensory Evidence of Decentralized Emotion
Kryklywy, J. H., Ehlers, M. R., Anderson, A. K., & Todd, R. M. (2020) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2020.08.002 · Cited by 30
“Valenced sensory signals project to structures mediating modality-general representations of affect, including vmPFC/OFC, amygdala, ACC, and insular cortex [12,87,113], where dominant inputs are cortico-cortico projections rather than raw sensation [112,137].”
BackgroundShared yet dissociable neural codes across eye gaze, valence and expectation
Pryluk, R., Shohat, Y., Morozov, A., Friedman, D., Taub, A. H., & Paz, R. (2020) · Nature · doi:10.1038/s41586-020-2740-8 · Cited by 36
McCullough, K. M., Chatzinakos, C., Hartmann, J., Missig, G., Neve, R. L., Fenster, R. J., Carlezon, W. A., Daskalakis, N. P., & Ressler, K. J. (2020) · Nature Communications · doi:10.1038/s41467-020-18985-6 · Cited by 32
“A main effect of CS number was found indicating decreased freezing responses with repeated CS presentation (two-way RM ANOVA: F(30, 540)= 5.”
Ko, M. J., Chiang, T., Mukadam, A. A., Mulia, G. E., Gutridge, A. M., Lin, A., Chester, J. A., & van Rijn, R. M. (2021) · Science Signaling · doi:10.1126/scisignal.aba0245 · Cited by 34
“7 of 13 brain regions and circuits involved in memory retrieval, locomotion, decision making, reward, and mood (52).”
BackgroundRecent advances in dopamine D 2 receptor ligands in the treatment of neuropsychiatric disorders
Jůza, R., Musílek, K., Mezeiová, E., Soukup, O., & Korábečný, J. (2022) · Medicinal Research Reviews · doi:10.1002/med.21923 · Cited by 34
In vivo diagnosis of TDP-43 proteinopathies: in search of biomarkers of clinical use
López‐Carbonero, J. I., García-Toledo, I., Fernández-Hernández, L., Bascuñana, P., Moreno, M., Matías‐Guiu, J. A., & Corrochano, S. (2024) · Translational Neurodegeneration · doi:10.1186/s40035-024-00419-8 · Cited by 35
“The amygdala is a key structure for behavior, expression and interpretation of emotions, and eating habits [40], all of which are potentially impaired in FTD and FTD-ALS [41], and it is not surprising that the amygdala and other limbic regions (such as the insular cortex and the hippocampus) are…”
BackgroundDamme, K. S. F., Young, C. B., & Nusslock, R. (2017) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsx017 · Cited by 35
“In addition to playing a central role in threat-processing and aversive learning (Janak and Tye, 2015), the amygdala has also been implicated in reward learning, appetitive motivation and goal-directed behavior (Wassum and Izquierdo, 2015).”
BackgroundInfluentialEnhanced processing of untrustworthiness in natural faces with neutral expressions.
Lischke, A., Junge, M., Hamm, A. O., & Weymar, M. (2017) · Emotion · doi:10.1037/emo0000318 · Cited by 33
Vega-Torres, J. D., Haddad, E., Lee, J. B., Kalyan-Masih, P., Maldonado, W. I., Pérez, L. L., Vázquez, D. M. P., Torres, Y. A., Santiago, J. M., Obenaus, A., et al. (2018) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2018.01.011 · Cited by 33
Yu, Z., Swiercz, A. P., Moshfegh, C. M., Hopkins, L. S., Wiaderkiewicz, J., Speth, R. C., Park, J., & Marvar, P. J. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.05.027 · Cited by 32
Morgan, A., Kondev, V., Bedse, G., Báldi, R., Marcus, D. J., & Patel, S. (2019) · Neurobiology of Stress · doi:10.1016/j.ynstr.2019.100190 · Cited by 32
“(Zhang and Rosenkranz, 2012; Janak and Tye, 2015; Felix-Ortiz et al., 2016) and increases in activity after chronic stress (Zhang et al.”
BackgroundRovira-Esteban, L., Gunduz‐Cinar, O., Bukalo, O., Limoges, A., Brockway, E. T., Müller, K., Fenno, L. E., Kim, Y. S., Ramakrishnan, C., Andrási, T., et al. (2019) · eNeuro · doi:10.1523/eneuro.0220-19.2019 · Cited by 34
“The amygdala is comprised of an assortment of cells which differ in their neurochemical identity and efferent and afferent connectivity, but the functional contribution of specific neuronal subpopulations to fear and extinction remains to be fully elucidated (Janak and Tye, 2015).”
BackgroundHuang, S.-H., Liu, W.-Z., Qin, X., Guo, C.-Y., Xiong, Q.-C., Wang, Y., Hu, P., Pan, B., & Zhang, W.-H. (2021) · Neuroscience Bulletin · doi:10.1007/s12264-021-00762-0 · Cited by 33
Transcriptomics reveals amygdala neuron regulation by fasting and ghrelin thereby promoting feeding
Peters, C., He, S., Fermani, F., Lim, H., Ding, W., Mayer, C., & Klein, R. (2023) · Science Advances · doi:10.1126/sciadv.adf6521 · Cited by 29
“Here, we focus on the central amygdala (CeA), an evolutionarily ancient subcortical structure that controls emotional processing and promotes defensive and appetitive behaviors (Janak and Tye, 2015), including food intake and reward processing (Cai et al.”
Lai, T. T., Gericke, B., Feja, M., Conoscenti, M. A., Zelikowsky, M., & Richter, F. (2023) · npj Parkinson s Disease · doi:10.1038/s41531-023-00547-4 · Cited by 34
Weiwei, Z., Yan, Y., Gu, X., In-young, K. S., Ryan, C., Modupe, L., Dix Thomas, A., Wei, L., & Ping, Y. S. (2020) · Aging and Disease · doi:10.14336/ad.2019.0507 · Cited by 31
“Basic research suggests that neuronal circuits involving BLA affect different anxious behaviors [41].”
BackgroundInvestigating the Subcortical Route to the Amygdala Across Species and in Disordered Fear Responses
McFadyen, J. (2019) · Journal of Experimental Neuroscience · doi:10.1177/1179069519846445 · Cited by 32
Palermo, S., Morese, R., Zibetti, M., Dematteis, F., Sirgiovanni, S., Stanziano, M., Valentini, M. C., & Lopiano, L. (2017) · Journal of Advanced Research · doi:10.1016/j.jare.2017.09.004 · Cited by 30
Sahafi, O. H., Sardari, M., Alijanpour, S., & Rezayof, A. (2023) · Brain Sciences · doi:10.3390/brainsci13050815 · Cited by 33
“The amygdaloid complex is involved in emotional and motivational behaviors as well as in processing fearful and rewarding environmental stimuli [80].”
BackgroundThe human social cognitive network contains multiple regions within the amygdala
Edmonds, D., Salvo, J. J., Anderson, N. L., Lakshman, M., Yang, Q., Kay, K., Zelano, C., & Braga, R. M. (2024) · Science Advances · doi:10.1126/sciadv.adp0453 · Cited by 35
“The amygdala is a complex structure that contains multiple nuclei with distinct roles and connections ( 10 , 87 , 126 ).”
InfluentialAfferent and efferent projections of the anterior cortical amygdaloid nucleus in the mouse
Cádiz‐Moretti, B., Abellán‐Álvaro, M., Pardo‐Bellver, C., Martínez‐Garciá, F., & Lanuza, E. (2017) · The Journal of Comparative Neurology · doi:10.1002/cne.24248 · Cited by 30
“The discovery of the critical role of the basolateral and central amygdaloid nuclei in fear learning has led to an extensive research focused on these areas (Janak & Tye, 2015), while the chemosensory structures of the amygdala have received much less attention.”
Functional roles of orexin/hypocretin receptors in reward circuit
Haghparast, A., Fatahi, Z., Arezoomandan, R., Karimi, S., Taslimi, Z., & Zarrabian, S. (2017) · Progress in brain research · doi:10.1016/bs.pbr.2017.08.005 · Cited by 32
“…learning and role for the projections from the BLA in mediating fear and anxiety behaviors are well established, these effects appear to be mediated distinctly from those BLA projections to the NAc, as the BLA–NAc microcircuit is involved in reward and reinforcement drive (Janak and Tye, 2015).”
BackgroundGuthman, E. M., Garcia, J. D., Ma, M., Chu, P., Baca, S. M., Smith, K. R., Restrepo, D., & Huntsman, M. M. (2020) · eLife · doi:10.7554/elife.50601 · Cited by 35
“The BLA is key in the formation of these associations (Duvarci and Pare, 2014; Janak and Tye, 2015).”
BackgroundFedele, T., Tzovara, A., Steiger, B. K., Hilfiker, P., Grünwald, T., Stieglitz, L. H., Jokeit, H., & Sarnthein, J. (2020) · NeuroImage · doi:10.1016/j.neuroimage.2020.116705 · Cited by 31
“, 2014), or aversive learning (Janak and Tye, 2015), rely on neural responses within the amygdala.”
BackgroundSchmitt, A., Upadhyay, N., Martin, J. A., Vega, S. R., Strüder, H. K., & Boecker, H. (2020) · Neural Plasticity · doi:10.1155/2020/7905387 · Cited by 34
“Based on initial work reporting exercise-induced alterations in the ARN [7–9] and the integral role of the amygdala within this network [11], we predicted exercise-induced changes in amygdalar-ARN rs-FC which are (a) exercise intensity dependent and (b) linked with a positive mood.”
BackgroundWorkman, C. I., Yoder, K. J., & Decety, J. (2020) · AJOB Neuroscience · doi:10.1080/21507740.2020.1811798 · Cited by 32
Voxel-Based Meta-Analysis of Gray Matter Abnormalities in Multiple System Atrophy
Lin, J., Xu, X., Hou, Y., Yang, J., & Shang, H. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.591666 · Cited by 31
“The amygdala is also an important structure that plays a role in cognitive-affective network (Janak and Tyke, 2015).”
BackgroundEngaging endogenous opioid circuits in pain affective processes
Kimmey, B. A., McCall, N. M., Wooldridge, L. M., Satterthwaite, T. D., & Corder, G. F. (2020) · Journal of Neuroscience Research · doi:10.1002/jnr.24762 · Cited by 31
“Furthermore, the BLA integrates with higher order corticostriatal circuits (Burgos-Robles et al., 2017; Janak & Tye, 2015; Ji et al., 2010; Ramirez et al., 2015), whereas the CeA largely influences descending nociception-control circuits, such as the ventrolateral periaqueductal gray (PAG, Fox &…”
BackgroundKim, D. J., Jassar, H., Lim, M., Nascimento, T. D., & DaSilva, A. F. M. (2021) · Journal of Pain Research · doi:10.2147/jpr.s296540 · Cited by 31
Inhibitory Circuits in the Basolateral Amygdala in Aversive Learning and Memory
Perumal, M. B., & Sah, P. (2021) · Frontiers in Neural Circuits · doi:10.3389/fncir.2021.633235 · Cited by 31
“The development of genetically driven markers and opto/chemo genetic tools to control and manipulate targeted population of neurons is now rapidly advancing our understanding of processing within the BLA (Janak and Tye, 2015; Mobbs et al., 2019).”
BackgroundChen, L., Huang, S., Yang, C., Wu, F., Zheng, Q., He, Y., Yan, J., Luo, Y., & Galaj, E. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.686845 · Cited by 31
“One potential target is the amygdala, a brain region involved in associative learning between environment cues and appetitive stimuli (Janak and Tye, 2015).”
BackgroundMazzitelli, M., Marshall, K., Pham, A., Ji, G., & Neugebauer, V. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.668337 · Cited by 30
Inagaki, M., Inoue, K., Tanabe, S., Kimura, K., Takada, M., & Fujita, I. (2022) · Cerebral Cortex · doi:10.1093/cercor/bhac109 · Cited by 29
“Assuming local inhibition within the amygdala (Ehrlich et al. 2009; Janak and Tye 2015), fast subcortical excitation could initiate early suppression in another group of amygdala neurons.”
Poggi, G., Albiez, J., & Pryce, C. R. (2022) · Neurobiology of Stress · doi:10.1016/j.ynstr.2022.100451 · Cited by 31
“Integration of these studies with human findings is facilitated by taking account of the structural-functional analogy between primate bidirectional ACC-AMY pathways and rodent medial prefrontal cortex (mPFC, prelimbic (PrL) and infralimbic (IL) cortices)-AMY pathways (Janak and Tye, 2015; Laubach et al., 2018).”
BackgroundLiu, L., Lyu, T., Fu, M.-Y., Wang, L., Chen, Y., Hong, J., Chen, Q.-Y., Zhu, Y., Tan, Z., Liu, D., et al. (2022) · NeuroImage Clinical · doi:10.1016/j.nicl.2022.103168 · Cited by 33
“AMYG is a crucial part of the limbic system and is well-known for emotional processing (Janak and Tye, 2015; Marek et al., 2013).”
Meng, X., Grandjean, J., Sbrini, G., Schipper, P., Hofwijks, N., Stoop, J., Calabrese, F., & Homberg, J. R. (2022) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.2c00448 · Cited by 32
“Besides, amygdala plays a key role in emotional processing 16 including anxiety, fear learning, and memory 17,18 with γ -aminobutyric acid-ergic (GABAergic) interneurons serving critically for some inhibitory circuits.”
On the role of epigenetic modifications of HPA axis in posttraumatic stress disorder and resilience
Khan, Z., Messiri, N. E., Iqbal, E., Hassan, H., Tanweer, M. S., Sadia, S. R., Taj, M., Zaidi, U., Yusuf, K., Syed, N. I., et al. (2025) · Journal of Neurophysiology · doi:10.1152/jn.00345.2024 · Cited by 32
Liu, N., Liu, Q., Yang, Z., Xu, J., Fu, G., Zhou, Y., Li, H., Wang, Y., Liu, L., & Qian, Q. (2022) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14032 · Cited by 29
An amygdala-to-cingulate cortex circuit for conflicting choices in chronic pain
Valentinova, K., Acuña, M. A., Ntamati, N. R., Nevian, N. E., & Nevian, T. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.113125 · Cited by 33
Domin, H., & Śmiałowska, M. (2024) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105748 · Cited by 31
Melara, R. D., Ruglass, L. M., Fertuck, E. A., & Hien, D. A. (2018) · Biological Psychology · doi:10.1016/j.biopsycho.2018.01.017 · Cited by 33
Advancing clinical neuroscience through enhanced tools: Pediatric social anxiety as an example
Smith, A. R., Kircanski, K., Brotman, M. A., Quyen, B., Subar, A. R., Silk, J. S., Engel, S. G., Crosby, R. D., Harrewijn, A., White, L. K., et al. (2019) · Depression and Anxiety · doi:10.1002/da.22937 · Cited by 32
“It is important to extend EEG using techniques such as functional magnetic resonance imaging (fMRI) with better spatial resolution, since functioning of two adjacent brain areas can have opposite effects on defensive behaviors (Janak & Tye, 2015).”
MethodHühne-Landgraf, A., Volkmann, P., Stephan, M., Rossner, M. J., & Landgraf, D. (2020) · Genes Brain & Behavior · doi:10.1111/gbb.12661 · Cited by 32
“For instance, anxiety patients often show a hyperexcitability in the basolateral amygdala as a response to negative stimuli.(58,59) The exposure to an open field arena can trigger the expression of the neuronal activity marker gene in the anterior part of the BLA in mice.”
BackgroundMorphofunctional Alterations of the Hypothalamus and Social Behavior in Autism Spectrum Disorders
Carìa, A., Ciringione, L., & de Falco, S. (2020) · Brain Sciences · doi:10.3390/brainsci10070435 · Cited by 31
“Stimulation of amygdaloid OXT receptors is then assumed to inhibit these efferences’ activity so as to decrease aversive responses to socially-relevant stimuli [20,124,125], which would be increased in case of diminished amygdala activation.”
BackgroundCortical and Thalamic Interaction with Amygdala-to-Accumbens Synapses
Xia, S.-H., Yu, J. J., Huang, X., Sesack, S. R., Huang, Y. H., Schlüter, O. M., Cao, J., & Dong, Y. (2020) · Journal of Neuroscience · doi:10.1523/jneurosci.1121-20.2020 · Cited by 33
“…on the projections from the medial prefrontal cortex (mPFCp) and paraventricular nucleus of the thalamus (PVTp; Stevenson and Gratton, 2003; Mashhoon et al., 2010; Janak and Tye, 2015; Abivardi and Bach, 2017; Kerestes et al., 2017; Millan et al., 2017; Otis et al., 2019; Zhou and Zhu, 2019).”
BackgroundInfluentialFish as a model in social neuroscience: conservation and diversity in the social brain network
Ogawa, S., Pfaff, D. W., & Parhar, I. S. (2021) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/brv.12689 · Cited by 32
“Importantly, at least 10 groups of nerve cells, located in the pallial and subpallial regions (collectively named the amygdala), survived during evolution, and are crucial for social functions in tetrapods (Moreno & González, 2007; Maximino et al., 2013; Janak & Tye, 2015).”
BackgroundKerem, L., Water, A. L. V. D., Kuhnle, M. C., Harshman, S. G., Hauser, K., Eddy, K. T., Becker, K. R., Misra, M., Micali, N., Thomas, J. J., et al. (2021) · Journal of Clinical Child & Adolescent Psychology · doi:10.1080/15374416.2021.1894944 · Cited by 33
“We also detected trend-level differences in fMRI activation in the amygdala, a brain region critically involved in saliency and stimulus-reward learning (Janak & Tye, 2015).”
de Abreu, M. S., Giacomini, A. C. V. V., Demin, K. A., Galstyan, D. S., Zabegalov, K. N., Kolesnikova, T. O., Amstislavskaya, T. G., Strekalova, T. V., Petersen, E. V., & Kalueff, A. V. (2021) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2021.173205 · Cited by 31
Neural substrates of human fear generalization: A 7T-fMRI investigation
Huggins, A. A., Tomas, C. W., Parisi, E. A., Bennett, K. P., Miskovic, V., & Larson, C. L. (2021) · NeuroImage · doi:10.1016/j.neuroimage.2021.118308 · Cited by 31
Zhao, M., Zhu, Z., Li, H., Wang, W., Cheng, S., Qin, X., Wu, H., Liu, D., & Pan, F. (2021) · Journal of Affective Disorders · doi:10.1016/j.jad.2021.09.101 · Cited by 30
Raine, P. J., & Rao, H. (2022) · Brain Imaging and Behavior · doi:10.1007/s11682-022-00659-0 · Cited by 30
“It is however centrally involved in aversive association learning as well as reward learning (Janak & Tye, 2015; Wassum & Izquierdo, 2015).”
BackgroundKuniishi, H., Nakatake, Y., Sekiguchi, M., & Yamada, M. (2022) · Neuropsychopharmacology · doi:10.1038/s41386-022-01358-6 · Cited by 32
“In particular, the OFC sends a dense projection to the amygdala, which is a key structure for the generation of emotion and social cognition [19, 31, 40, 41].”
BackgroundPrefrontal circuits guiding social preference: Implications in autism spectrum disorder
Fortier, A. V., Meisner, O. C., Nair, A. R., & Chang, S. W. C. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104803 · Cited by 31
“Subcortically, the amygdala and NAc, both of which are largely conserved across our model species, play a critical role in social processing as well as both general and social reward processing (Janak and Tye, 2015; Balsters et al., 2020).”
BackgroundCraske, M. G., Herzallah, M. M., Nusslock, R., & Patel, V. (2023) · Nature Mental Health · doi:10.1038/s44220-022-00012-w · Cited by 31
“These paradigms probe circuits such as the cortico-amygdala circuit, which supports vigilance for, and responses to, threatening stimuli 12–14 .”
A single-cell atlas of the rat amygdala reveals molecular signatures of cocaine addiction
Zhou, J., de Guglielmo, G., Ho, A. J., Kallupi, M., Pokhrel, N. P., Li, H.-R., Chitre, A. S., Munro, D. B., Mohammadi, P., Carrette, L. L. G., et al. (2023) · Nature Neuroscience · doi:10.1038/s41593-023-01454-w · Cited by 33
“While the behavioral function and connectivity of the amygdala have been established 1 , the role of distinct neuronal and non-neuronal cell subpopulations in addiction remains unclear.”
BackgroundPatel, R., Girard, T. A., Pukay‐Martin, N. D., & Monson, C. M. (2016) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2016.02.003 · Cited by 30
Hu, Y., Moore, M., Bertels, Z., Phan, K. L., Dolcos, F., & Dolcos, S. M. (2017) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2017.11.008 · Cited by 34
“The AMY is an almond-shaped region located deep within each hemisphere of the medial temporal lobe (Janak and Tye, 2015).”
Serotonergic neuromodulation of synaptic plasticity
Higa, G. S. V., Viana, F. J. C., Francis-Oliveira, J., Cruvinel, E., Franchin, T. S., Marcourakis, T., Ulrich, H., & De Pasquale, R. (2024) · Neuropharmacology · doi:10.1016/j.neuropharm.2024.110036 · Cited by 29
Neumeister, P., Feldker, K., Heitmann, C. Y., Buff, C., Brinkmann, L., Bruchmann, M., & Straube, T. (2018) · Psychological Medicine · doi:10.1017/s0033291717002513 · Cited by 28
Extended‐amygdala intrinsic functional connectivity networks: A population study
Berry, S. C., Wise, R. G., Lawrence, A. D., & Lancaster, T. M. (2020) · Human Brain Mapping · doi:10.1002/hbm.25314 · Cited by 29
“Whist amygdala structural connections to lateral temporal regions are well characterised (Folloni et al., 2019; Janak & Tye, 2015; Klingler & Gloor, 1960), this is not the case for the BST and it has been suggested that BST-temporal pole connectivity may even be unique to humans (Avery et al.,…”
BackgroundNoritake, A., Ninomiya, T., & Isoda, M. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.02.018 · Cited by 29
Incentive disengagement and the adaptive significance of frustrative nonreward
Papini, M. R., Guarino, S., Hagen, C. W., & Torres, C. (2022) · Learning & Behavior · doi:10.3758/s13420-022-00519-3 · Cited by 29
“The dorso-medial telencephalon is considered homologous to parts of the mammalian amygdala (North-cutt, 2006), which is central to an understanding of fear and avoidance conditioning in mammals (Cain, 2019; Janak & Tye, 2015).”
BackgroundSubcortico-amygdala pathway processes innate and learned threats
Khalil, V., Faress, I., Mermet-Joret, N., Kerwin, P., Yonehara, K., & Nabavi, S. (2023) · eLife · doi:10.7554/elife.85459 · Cited by 28
“The LT-BLA pathway typically has been evaluated in relation to associative learnings (Janak and Tye, 2015; Tye et al., 2008), especially associative learned threats (Barsy et al.”
BackgroundPre-pubertal stress and brain development in rodents
Brydges, N. M. (2015) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2015.08.003 · Cited by 29
Yeh, L.-F., Watanabe, M., Cuevas, J. N. S., & Johansen, J. P. (2017) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2017.09.006 · Cited by 31
Beyond Emotions: Oscillations of the Amygdala and Their Implications for Electrical Neuromodulation
Schönfeld, L.-M., & Wojtecki, L. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00366 · Cited by 29
Kobrzycka, A. T., Napora, P., Pearson, B. L., Pierzchała, K., Szewczyk, R., & Wieczorek, M. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1544-y · Cited by 28
Amygdala subnucleus volumes in psychosis high-risk state and first-episode psychosis
Armio, R.-L., Laurikainen, H., Ilonen, T., Walta, M., Salokangas, R. K. R., Koutsouleris, N., Hietala, J. A., & Tuominen, L. J. (2019) · Schizophrenia Research · doi:10.1016/j.schres.2019.10.014 · Cited by 32
Kim, S.-R., & Kim, S. (2021) · Molecules and Cells · doi:10.14348/molcells.2021.0006 · Cited by 29
“Together, these studies suggest that glutamatergic and GABAergic BNST neurons might be oppositely regulated by motivationally salient stimuli, and can exert opposite influences on multiple behaviors (Bromberg-Martin et al., 2010; Janak and Tye, 2015).”
BackgroundYang, J., Palaniyappan, L. K., Xi, C., Cheng, Y., Fan, Z., Chen, C., Zhang, M., Pan, Y., Tao, H., Ouyang, X., et al. (2022) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2022.02.003 · Cited by 30
Kupferschmidt, D. A., Cummings, K. A., Joffe, M. E., MacAskill, A. F., Malik, R., Sánchez-Bellot, C., Tejeda, H. A., & Yarur, H. E. (2022) · Journal of Neuroscience · doi:10.1523/jneurosci.1136-22.2022 · Cited by 28
“…are thought to support the learning, expression, and updating of affective associations (e.g., aversive threat memory) (Sotres-Bayon et al., 2012; Janak and Tye, 2015), whereas vHPC inputs are thought to convey context, or state information on which associations can be formed (Gershman et al.,…”
BackgroundOverview on Research and Clinical Applications of Optogenetics
Towne, C. L., & Thompson, K. R. (2016) · Current Protocols in Pharmacology · doi:10.1002/cpph.13 · Cited by 29
Przybysz, K. R., Werner, D. F., & Diaz, M. R. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.01.036 · Cited by 29
Butler, R. K., Ehling, S., Barbar, M., Thomas, J., Hughes, M. A., Smith, C. E., Pogorelov, V. M., Aryal, D. K., Wetsel, W. C., & Lascelles, B. D. X. (2017) · Neuroscience Letters · doi:10.1016/j.neulet.2017.09.025 · Cited by 30
The Computational Complexity of Valuation and Motivational Forces in Decision-Making Processes
Redish, A. D., Schultheiss, N. W., & Carter, E. C. (2015) · Current topics in behavioral neurosciences · doi:10.1007/7854_2015_375 · Cited by 28
“Anatomically, this system depends on associations made within the amygdala (LeDoux 2000; Janak and Tye 2015) driving species-specific behaviors in the periaqueductal gray (Bandler and Shipley 1994; McNally et al. 2011), as well as simple approach/avoidance behaviors involving the shell of the…”
BackgroundBaumgartner, J. N., Quintana, D., Leija, L., Schuster, N. M., Bruno, K. A., Castellanos, J. P., & Case, L. K. (2021) · Journal of Pain · doi:10.1016/j.jpain.2021.07.009 · Cited by 33
Han, R.-W., Zhang, Z., Chen, J., Hu, Z.-Y., & Pan, B. (2024) · Nature Communications · doi:10.1038/s41467-024-47966-2 · Cited by 33
“The “ winner-takes-all ” strategy, alongside the extensive reciprocal inhibition among topographically and functionally divergent BLA PNs 27,30,32,59 – 62 , may allow for the integration of information from various sources with varying emotional valences within the BLA 9,12,13 .”
BackgroundAn Honest Reckoning With the Amygdala and Mental Illness
Fox, A. S., & Shackman, A. J. (2024) · American Journal of Psychiatry · doi:10.1176/appi.ajp.20240941 · Cited by 32
Spalek, K., Coynel, D., Freytag, V., Hartmann, F., Heck, A., Milnik, A., de Quervain, D. J. ‐., & Papassotiropoulos, A. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.20 · Cited by 27
Gage, M., Putra, M. R. E., Wachter, L., Dishman, K., Gard, M., Gomez-Estrada, C., & Thippeswamy, T. (2021) · Antioxidants · doi:10.3390/antiox11010061 · Cited by 28
“The AMY consists of a number of interconnected nuclei [142].”
BackgroundA neuronal social trait space for first impressions in the human amygdala and hippocampus
Cao, R., Lin, C., Hodge, J., Li, X., Todorov, A. T., Brandmeir, N. J., & Wang, S. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01583-x · Cited by 27
“A future study with more precise localization of the recording locations is needed to further elucidate the roles of different subregions of the amygdala and hippocampus in encoding social traits, especially given the revised views of the amygdala and hippocampal circuits [40, 41] and in the context of mesial temporal…”
Background
Metadata
- Authors
- Janak, P. H., & Tye, K. M.
- Affiliations
- Johns Hopkins University (US)
- Massachusetts Institute of Technology (US)
- Corresponding author
- Janak, Patricia H.
- Tye, Kay M.
- Venue
- Nature
- Published
- 2015-01-14
- Volume
- 517
- Issue
- 7534
- Pages
- 284-292
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC4565157
- OpenAlex
- W1989982790
- Cited by
- 2,011
- References
- 126
- Citations by year
- 2026: 149 · 2025: 193 · 2024: 198 · 2023: 210 · 2022: 207 · 2021: 234 · 2020: 225 · 2019: 172 · 2018: 132 · 2017: 119 · 2016: 114 · 2015: 56
- FWCI
- 13.69
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- DSpace@MIT (Massachusetts Institute of Technology) (submittedVersion, cc-by-nc-sa)
- PMC
- Funders
- New York Stem Cell Foundation
- JPB Foundation
- National Institutes of Health
- National Institute on Alcohol Abuse and Alcoholism (R01AA014925, AA17072, AA014925, P50AA017072, R01AA016835)
- National Institute of Mental Health (R01MH102441, MH102441, R37MH102441)
- National Institute on Drug Abuse (DA015096, R01DA015096, R01DA035943)
- National Institute of Diabetes and Digestive and Kidney Diseases (DP2DK102256)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- amygdala, neural circuits, emotions, motivation, fear, reward, behavioural function, structural connectivity, causal manipulation
- MeSH terms
- Amygdala, Animals, Behavior, Biological Evolution, Fear, Humans, Memory, Neural Pathways, Reward
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
