Global research challenges and opportunities for mental health and substance-use disorders

Baingana, Florence; al'Absi, Mustafa; Becker, Anne E.; Pringle, Beverly

doi:10.1038/nature16032

Cited by 139Mental Health Treatment and AccessMigration, Health and TraumaGlobal Health and Surgery

Global research challenges and opportunities for mental health and substance-use disorders

Open access

Baingana, Florence, al'Absi, Mustafa, Becker, Anne E., Pringle, Beverly·2015·Nature

DOI 10.1038/nature16032PMC PMC6368440

Open this paper in CoChat — free account Open PDF

Abstract

The research agenda for global mental health and substance-use disorders has been largely driven by the exigencies of high health burdens and associated unmet needs in low- and middle-income countries. Implementation research focused on context-driven adaptation and innovation in service delivery has begun to yield promising results that are improving the quality of, and access to, care in low-resource settings. Importantly, these efforts have also resulted in the development and augmentation of local, in-country research capacities. Given the complex interplay between mental health and substance-use disorders, medical conditions, and biological and social vulnerabilities, a revitalized research agenda must encompass both local variation and global commonalities in the impact of adversities, multi-morbidities and their consequences across the life course. We recommend priorities for research — as well as guiding principles for context-driven, intersectoral, integrative approaches — that will advance knowledge and answer the most pressing local and global mental health questions and needs, while also promoting a health equity agenda and extending the quality, reach and impact of scientific enquiry. This article has not been written or reviewed by Nature editors. Nature accepts no responsibility for the accuracy of the information provided.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1038/nature16032

Cites

65 of 65 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

The lack of valid and pragmatic assessments for implementation-related factors and outcomes has been noted in the health services and implementation science literature and echoed by researchers across health-related interventions.
“Furthermore, the lack of valid and pragmatic assessments for implementation-related factors and outcomes has been noted in the health services and implementation science literature [110, 111] and has been echoed by researchers across health-related interventions [112].”
From Barriers and facilitators to implementation of evidence-based task-sharing mental health interventions in low- and middle-income countries: a systematic review using implementation science frameworks (2022) · cites this paper as [110]
The Health Delivery and Implementation Research section identifies gaps in knowledge about implementing mental-health interventions and calls for better diagnostic assessment and population surveillance. It does not say that valid, pragmatic assessments of implementation-related factors or outcomes are lacking; searches for that claim and for implementation measures found no supporting passage. (LLM, conf=0.73)
Experimental — accuracy not yet measured
There is widespread consensus that integrating mental health services into primary and community healthcare settings and task-sharing are essential for addressing the global treatment gap.
“There is widespread consensus that integrating mental health services into primary and community healthcare settings and task-sharing are essential for addressing the global treatment gap.7,8”
From Digital Technology for Building Capacity of Nonspecialist Health Workers for Task Sharing and Scaling Up Mental Health Care Globally (2019) · cites this paper as [7]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010
Murray, C. J. L., Vos, T., Lozano, R., Naghavi, M., Flaxman, A. D., Michaud, C., Ezzati, M., Shibuya, K., Salomon, J. A., Abdalla, S., et al. (2012) · The Lancet · doi:10.1016/s0140-6736(12)61689-4 · Cited by 8,888 · see citing works
Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010
Vos, T., Flaxman, A. D., Naghavi, M., Lozano, R., Michaud, C., Ezzati, M., Shibuya, K., Salomon, J. A., Abdalla, S., Aboyans, V., et al. (2012) · The Lancet · doi:10.1016/s0140-6736(12)61729-2 · Cited by 8,291 · see citing works
Closing the gap in a generation: health equity through action on the social determinants of health
Marmot, M. G., Friel, S., Bell, R., Houweling, T. A. J., & Taylor, S. A. J. (2008) · The Lancet · doi:10.1016/s0140-6736(08)61690-6 · Cited by 8,238 · see citing works
Global burden of disease attributable to mental and substance use disorders: findings from the Global Burden of Disease Study 2010
Whiteford, H. A., Degenhardt, L., Rehm, J., Baxter, A. J., Ferrari, A. J., Erskine, H. E., Charlson, F. J., Norman, R. E., Flaxman, A. D., Johns, N., et al. (2013) · The Lancet · doi:10.1016/s0140-6736(13)61611-6 · Cited by 6,006 · see citing works
Prevalence, Severity, and Unmet Need for Treatment of Mental Disorders in the World Health Organization World Mental Health Surveys
(2004) · JAMA · doi:10.1001/jama.291.21.2581 · Cited by 3,448 · see citing works
The Self-Medication Hypothesis of Substance Use Disorders: A Reconsideration and Recent Applications
Khantzian, E. J. (1997) · Harvard Review of Psychiatry · doi:10.3109/10673229709030550 · Cited by 3,242 · see citing works
Child and adolescent mental health worldwide: evidence for action
Kieling, C., Baker-Henningham, H., Belfer, M., Conti, G., Ertem, I., Omigbodun, O., Rohde, L. A., Srinath, S., Ulkuer, N., & Rahman, A. (2011) · The Lancet · doi:10.1016/s0140-6736(11)60827-1 · Cited by 2,449 · see citing works
Cannabis use and risk of psychotic or affective mental health outcomes: a systematic review.
Moore, T. H., Zammit, S., Lingford-Hughes, A., Barnes, T. R., Jones, P. B., Burke, M., & Lewis, G. (2007) · The Lancet · doi:10.1016/s0140-6736(07)61162-3 · Cited by 2,224 · see citing works
Grand challenges in global mental health
Collins, P. Y., Patel, V., Joestl, S. S., March, D., Insel, T. R., Daar, A. S., Bordin, I. A., Costello, E. J., Durkin, M., Fairburn, C., et al. (2011) · Nature · doi:10.1038/475027a · Cited by 2,043 · see citing works
Untitled work
(2012) · RePEc: Research Papers in Economics · Cited by 1,951 · see citing works
Resources for mental health: scarcity, inequity, and inefficiency
Saxena, S., Thornicroft, G., Knapp, M., & Whiteford, H. (2007) · The Lancet · doi:10.1016/s0140-6736(07)61239-2 · Cited by 1,789 · see citing works
Use of mental health services for anxiety, mood, and substance disorders in 17 countries in the WHO world mental health surveys
Wang, P. S., Aguilar-Gaxiola, S., Alonso, J., Angermeyer, M. C., Borges, G., Bromet, E. J., Bruffaerts, R., de Girolamo, G., de Graaf, R., Gureje, O., et al. (2007) · The Lancet · doi:10.1016/s0140-6736(07)61414-7 · Cited by 1,655 · see citing works
Cognitive behaviour therapy-based intervention by community health workers for mothers with depression and their infants in rural Pakistan: a cluster-randomised controlled trial
Rahman, A., Malik, A., Sikander, S., Roberts, C., & Creed, F. (2008) · The Lancet · doi:10.1016/s0140-6736(08)61400-2 · Cited by 993 · see citing works
Scale up services for mental disorders: a call for action
(2007) · The Lancet · doi:10.1016/s0140-6736(07)61242-2 · Cited by 835 · see citing works
Neighborhood Effects on the Long-Term Well-Being of Low-Income Adults
Ludwig, J., Duncan, G. J., Gennetian, L. A., Katz, L. F., Kessler, R. C., Kling, J. R., & Sanbonmatsu, L. (2012) · Science · doi:10.1126/science.1224648 · Cited by 747 · see citing works
Scale up of services for mental health in low-income and middle-income countries
Eaton, J., McCay, L., Semrau, M., Chatterjee, S., Baingana, F., Araya, R., Ntulo, C., Thornicroft, G., & Saxena, S. (2011) · The Lancet · doi:10.1016/s0140-6736(11)60891-x · Cited by 698 · see citing works
Self-citation
The epidemiology of dual diagnosis
Kessler, R. C. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.06.034 · Cited by 588 · see citing works
Non-specialist health worker interventions for the care of mental, neurological and substance-abuse disorders in low- and middle-income countries
van Ginneken, N., Tharyan, P., Lewin, S., Rao, G. N., Meera, S., Pian, J., Chandrashekar, S., & Patel, V. (2013) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd009149.pub2 · Cited by 575 · see citing works
Prevalence of attention-deficit hyperactivity disorder in substance use disorder patients: A meta-analysis and meta-regression analysis
van Emmerik-van Oortmerssen, K., van de Glind, G., van den Brink, W., Smit, F., Crunelle, C. L., Swets, M., & Schoevers, R. A. (2012) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2011.12.007 · Cited by 535 · see citing works
Human rights violations of people with mental and psychosocial disabilities: an unresolved global crisis
Drew, N., Funk, M., Tang, S., Lamichhane, J., Chávez, E., Katontoka, S., Pathare, S., Lewis, O., Gostin, L. O., & Saraceno, B. (2011) · The Lancet · doi:10.1016/s0140-6736(11)61458-x · Cited by 438 · see citing works
The mental health workforce gap in low- and middle-income countries: a needs-based approach
Bruckner, T. A., Scheffler, R. M., Shen, G., Yoon, J., Chisholm, D., Morris, J., Fulton, B. D., Dal Poz, M. R., & Saxena, S. (2011) · Bulletin of the World Health Organization · doi:10.2471/blt.10.082784 · Cited by 433 · see citing works
Posttraumatic stress disorder prevalence and risk of recurrence in acute coronary syndrome patients: a meta-analytic review.
Edmondson, D., Richardson, S., Falzon, L., Davidson, K. W., Mills, M. A., & Neria, Y. (2012) · PLoS ONE · doi:10.1371/journal.pone.0038915 · Cited by 400 · see citing works
Acceptability and feasibility of using non-specialist health workers to deliver mental health care: Stakeholder perceptions from the PRIME district sites in Ethiopia, India, Nepal, South Africa, and Uganda
Mendenhall, E., De Silva, M. J., Hanlon, C., Petersen, I., Shidhaye, R., Jordans, M., Luitel, N., Ssebunnya, J., Fekadu, A., Patel, V., et al. (2014) · Social Science & Medicine · doi:10.1016/j.socscimed.2014.07.057 · Cited by 355 · see citing works
Cultural concepts of distress and psychiatric disorders: literature review and research recommendations for global mental health epidemiology
Kohrt, B. A., Rasmussen, A., Kaiser, B. N., Haroz, E. E., Maharjan, S. M., Mutamba, B. B., de Jong, J. T., & Hinton, D. E. (2014) · International Journal of Epidemiology · doi:10.1093/ije/dyt227 · Cited by 355 · see citing works
Mood Disorders and Substance Use Disorder: A Complex Comorbidity
Quello, S. B., Brady, K. T., & Sonne, S. C. (2005) · Science & Practice Perspectives · doi:10.1151/spp053113 · Cited by 326 · see citing works
A randomized controlled trial evaluating the impact of knowledge translation and exchange strategies
Dobbins, M., Hanna, S., Ciliska, D. K., Manske, S., Cameron, R., Mercer, S. L., O’Mara, L., DeCorby, K., & Robeson, P. (2009) · Implementation Science · doi:10.1186/1748-5908-4-61 · Cited by 322 · see citing works
Lay health worker led intervention for depressive and anxiety disorders in India: impact on clinical and disability outcomes over 12 months
Patel, V., Weiss, H. A., Chowdhary, N., Naik, S., Pednekar, S., Chatterjee, S., Bhat, B., Araya, R., King, M., Simon, G., et al. (2011) · British Journal of Psychiatry · doi:10.1192/bjp.bp.111.092155 · Cited by 291 · see citing works
Global mental health: a failure of humanity
Kleinman, A. (2009) · The Lancet · doi:10.1016/s0140-6736(09)61510-5 · Cited by 242 · see citing works
The reality of comorbidity: Depression and drug abuse
Volkow, N. D. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.07.007 · Cited by 213 · see citing works
The Effect of Psychosocial Syndemic Production on 4-Year HIV Incidence and Risk Behavior in a Large Cohort of Sexually Active Men Who Have Sex With Men
Mimiaga, M. J., O'Cleirigh, C., Biello, K. B., Robertson, A. M., Safren, S. A., Coates, T. J., Koblin, B. A., Chesney, M. A., Donnell, D. J., Stall, R. D., et al. (2015) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0000000000000475 · Cited by 201 · see citing works
Attenuated adrenocorticotropic responses to psychological stress are associated with early smoking relapse
al’Absi, M., Hatsukami, D., & Davis, G. L. (2005) · Psychopharmacology · doi:10.1007/s00213-005-2225-3 · Cited by 192 · see citing works
Self-citation
Preparing for Responsible Sharing of Clinical Trial Data
Mello, M. M., Francer, J. K., Wilenzick, M., Teden, P., Bierer, B. E., & Barnes, M. (2013) · New England Journal of Medicine · doi:10.1056/nejmhle1309073 · Cited by 175 · see citing works
Contribution of low- and middle-income countries to research published in leading general psychiatry journals, 2002–2004
Patel, V., & Kim, Y. (2006) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.106.025692 · Cited by 158 · see citing works
Mental and Substance Use Disorders in Sub-Saharan Africa: Predictions of Epidemiological Changes and Mental Health Workforce Requirements for the Next 40 Years
Charlson, F., Diminic, S., Lund, C., Degenhardt, L. J., & Whiteford, H. (2014) · PLoS ONE · doi:10.1371/journal.pone.0110208 · Cited by 156 · see citing works
Stress and Addiction: Biological and Psychological Mechanisms.
Al’Absi, M. (2007) · Cited by 144 · see citing works
Self-citation
The Association between Hypertension and Depression and Anxiety Disorders: Results from a Nationally-Representative Sample of South African Adults
Grimsrud, A., Stein, D. J., Seedat, S., Williams, D. R., & Myer, L. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005552 · Cited by 143 · see citing works
Why mental health matters to global health
Patel, V. (2014) · Transcultural Psychiatry · doi:10.1177/1363461514524473 · Cited by 136 · see citing works
Independent protein-profiling studies show a decrease in apolipoprotein A1 levels in schizophrenia CSF, brain and peripheral tissues
Huang, J. T.-J., Wang, L., Prabakaran, S., Wengenroth, M., Lockstone, H. E., Koethe, D., Gerth, C. W., Gross, S., Schreiber, D., Lilley, K. S., et al. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4002108 · Cited by 133 · see citing works
Scarcity and inequity of mental health research resources in low-and-middle income countries: A global survey
Razzouk, D., Sharan, P., Gallo, C., Gureje, O., Lamberte, E. E., Mari, J. D. J., Mazzotti, G., Patel, V., Swartz, L. M., Olifson, S., et al. (2009) · Health Policy · doi:10.1016/j.healthpol.2009.09.009 · Cited by 131 · see citing works
Cost-Effectiveness of a Primary Care Treatment Program for Depression in Low-Income Women in Santiago, Chile
Araya, R., Flynn, T., Rojas, G., Fritsch, R., & Simon, G. (2006) · American Journal of Psychiatry · doi:10.1176/ajp.2006.163.8.1379 · Cited by 128 · see citing works
Capacity Building in Global Mental Health: Professional Training
Fricchione, G. L., Borba, C. P. C., Alem, A., Shibre, T., Carney, J. R., & Henderson, D. C. (2012) · Harvard Review of Psychiatry · doi:10.3109/10673229.2012.655211 · Cited by 120 · see citing works
Capacity Building in Global Mental Health Research
Thornicroft, G., Cooper, S., Bortel, T. V. V., Kakuma, R., & Lund, C. (2012) · Harvard Review of Psychiatry · doi:10.3109/10673229.2012.649117 · Cited by 118 · see citing works
Classification of mental disorders: a global mental health perspective
Jacob, K. S., & Patel, V. (2014) · The Lancet · doi:10.1016/s0140-6736(13)62382-x · Cited by 117 · see citing works
Dual diagnosis in the suburbs: prevalence, need, and in-patient service use
Wright, S., Gournay, K., Glorney, E., & Thornicroft, G. (2000) · Social Psychiatry and Psychiatric Epidemiology · doi:10.1007/s001270050242 · Cited by 86 · see citing works
The Global Burden of Disease projects: What have we learned about illicit drug use and dependence and their contribution to the global burden of disease?
Degenhardt, L. J., Whiteford, H., & Hall, W. (2013) · Drug and Alcohol Review · doi:10.1111/dar.12088 · Cited by 82 · see citing works
Impaired decision-making in psychopathic heroin addicts
Vassileva, J., Petkova, P., Georgiev, S., Martin, E. M., Tersiyski, R., Raycheva, M. R., Velinov, V. T., & Marinov, P. (2006) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2006.06.015 · Cited by 73 · see citing works
Women's alcohol consumption and risk for alcohol‐exposed pregnancies in Russia
Balachova, T. N., Bonner, B. L., Chaffin, M. J., Bard, D., Isurina, G., Tsvetkova, L., & Volkova, E. (2011) · Addiction · doi:10.1111/j.1360-0443.2011.03569.x · Cited by 70 · see citing works
Non-specialist health worker interventions for mental health care in low- and middle- income countries
van Ginneken, N., Tharyan, P., Lewin, S. A., Rao, G. N., Romeo, R., & Patel, V. (2011) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd009149 · Cited by 69 · see citing works
US medical specialty global health training and the global burden of disease
Kerry, V. B., Walensky, R. P., Tsai, A. C., Bergmark, R. W., Bergmark, B. A., Rouse, C. D., & Bangsberg, D. R. (2013) · Journal of Global Health · doi:10.7189/jogh.03.020406 · Cited by 64 · see citing works
Genetic markers associated with abstinence length in alcohol-dependent subjects treated with acamprosate
Karpyak, V. M., Biernacka, J. M., Geske, J. R., Jenkins, G. D., Cunningham, J. M., Rüegg, J., Kononenko, O., Leontovich, A. A., Abulseoud, O. A., Hall‐Flavin, D. K., et al. (2014) · Translational Psychiatry · doi:10.1038/tp.2014.103 · Cited by 60 · see citing works
The utility of biomarker discovery approaches for the detection of disease mechanisms in psychiatric disorders
Schwarz, E., & Bahn, S. (2008) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707658 · Cited by 59 · see citing works
Peptide YY and ghrelin predict craving and risk for relapse in abstinent smokers
Al’Absi, M., Lemieux, A. M., & Nakajima, M. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.07.018 · Cited by 51 · see citing works
Self-citation
Can China's new mental health law substantially reduce the burden of illness attributable to mental disorders?
Phillips, M. R. (2013) · The Lancet · doi:10.1016/s0140-6736(13)61177-0 · Cited by 50 · see citing works
Decreased frontal N-acetylaspartate levels in adolescents concurrently using both methamphetamine and marijuana
Sung, Y., Carey, P. D., Stein, D. J., Ferrett, H. L., Spottiswoode, B. S., Renshaw, P. F., & Yurgelun-Todd, D. A. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.02.028 · Cited by 45 · see citing works
A Narrative Review of Recent Developments in Knowledge Translation and Implications for Mental Health Care Providers
Goldner, E. M., Jenkins, E., & Fischer, B. (2014) · The Canadian Journal of Psychiatry · doi:10.1177/070674371405900308 · Cited by 27 · see citing works
Managing for Health
Berg, M., Huijsman, R., Hunter, D. J., & Øvretveit, J. (2007) · Routledge eBooks · doi:10.4324/9780203014349 · Cited by 27 · see citing works
Challenges of creating synergy between global mental health and cultural psychiatry
de Jong, J. T. V. M. (2014) · Transcultural Psychiatry · doi:10.1177/1363461514557995 · Cited by 26 · see citing works
Epigenetic biomarkers in psychiatric disorders
Peedicayil, J. (2008) · British Journal of Pharmacology · doi:10.1038/bjp.2008.254 · Cited by 21 · see citing works
Association of depressive symptoms and social support on blood pressure among urban African American women and girls
Wu, C. Y., Prosser, R. A., & Taylor, J. Y. (2010) · Journal of the American Academy of Nurse Practitioners · doi:10.1111/j.1745-7599.2010.00565.x · Cited by 20 · see citing works
Global Health Training in US Graduate Psychiatric Education
Tsai, A. C., Fricchione, G. L., Walensky, R. P., Ng, C., Bangsberg, D. R., & Kerry, V. B. (2014) · Academic Psychiatry · doi:10.1007/s40596-014-0092-0 · Cited by 18 · see citing works
Mental health is integral to public health: a call to scale up evidence-based services and develop mental health research.
Lund, C., Stein, D. J., Corrigall, J., Bradshaw, D., Schneider, M. M., & Flisher, A. J. (2008) · PubMed · Cited by 17 · see citing works
Global priorities of civil society for mental health services: findings from a 53 country survey
Copeland, J. R. M., Thornicroft, G., Bird, V., Bowis, J., & Slade, M. (2014) · World Psychiatry · doi:10.1002/wps.20133 · Cited by 13 · see citing works
Psychiatry
(2014) · Oxford University Press eBooks · doi:10.1093/med/9780199638963.001.0001 · Cited by 9 · see citing works
Research-informed public health
Øvretveit, J. (2007) · Routledge health management series · doi:10.4324/9780203014349.ch6 · Cited by 7 · see citing works
Depression, Diabetic Complications and Disability Among Persons With Comorbid Schizophrenia and Type 2 Diabetes
Lee, A. A., McKibbin, C. L., Bourassa, K. A., Wykes, T. L., & Andren, K. A. K. (2014) · Psychosomatics · doi:10.1016/j.psym.2013.12.015 · Cited by 5 · see citing works

Flagged first, then by citations

1 of the 66 references couldn’t be matched to a known paper.

Research works printed but not linked: 2

[1]Becker AE A. Kleinman. In Psychiatry: Past. Present, and Prospect (eds Bloch S. Green S & Holmes J) (Oxford Univ. Press 2013).
[45]World Health Organization. WHO mhGAP Intervention Guide for Mental. Neurological, and Substance use Disorders in Non-Specialized Health Settings http://www.who.int/mental_health/publications/mhGAP_intervention_guide/en/index.html(WHO 2010) 23741783

Sorted by citations

Barriers and facilitators to implementation of evidence-based task-sharing mental health interventions in low- and middle-income countries: a systematic review using implementation science frameworks
Le, P. D., Eschliman, E. L., Grivel, M. M., Tang, J., Cho, Y. G., Yang, X., Tay, C., Li, T., Bass, J., & Yang, L. H. (2022) · Implementation Science · doi:10.1186/s13012-021-01179-z · Cited by 233 · see citing works
“Furthermore, the lack of valid and pragmatic assessments for implementation-related factors and outcomes has been noted in the health services and implementation science literature [110, 111] and has been echoed by researchers across health-related interventions [112].”
Background
Digital Technology for Building Capacity of Nonspecialist Health Workers for Task Sharing and Scaling Up Mental Health Care Globally
Naslund, J. A., Shidhaye, R., & Patel, V. (2019) · Harvard Review of Psychiatry · doi:10.1097/hrp.0000000000000217 · Cited by 159 · see citing works
A survey on big data-driven digital phenotyping of mental health
Liang, Y., Zheng, X., & Zeng, D. D. (2019) · Information Fusion · doi:10.1016/j.inffus.2019.04.001 · Cited by 154 · see citing works
Assessing the Causal Effects of Human Serum Metabolites on 5 Major Psychiatric Disorders
Yang, J., Yan, B., Zhao, B., Fan, Y., He, X., Yang, L., Ma, Q., Zheng, J., Wang, W., Bai, L., et al. (2019) · Schizophrenia Bulletin · doi:10.1093/schbul/sbz138 · Cited by 143 · see citing works
“Hereby making use of the GDMs and latest GWAS findings on psychiatric disorders, we conducted this twosample (genetic associations with the exposure and outcome are measured in different samples) MR approach to: (1) assess the causal effects of human blood metabolites on 5 major psychiatric disorders, which respective…”
Method
Mental health research in the Arab region: challenges and call for action
Maalouf, F. T., Alamiri, B., Atweh, S., Becker, A. E., Cheour, M., Darwish, H., Ghandour, L. A., Ghuloum, S., Hamzé, M., Karam, E. G., et al. (2019) · The Lancet Psychiatry · doi:10.1016/s2215-0366(19)30124-5 · Cited by 110 · see citing works
Self-citation
Promotion, prevention and treatment interventions for mental health in low- and middle-income countries through a task-shifting approach
Purgato, M., Uphoff, E., Singh, R. K., Pachya, A. T., Abdulmalik, J. O., & van Ginneken, N. (2020) · Epidemiology and Psychiatric Sciences · doi:10.1017/s204579602000061x · Cited by 96 · see citing works
“Unlike HICs, in LMICs, factors as the socioecology of poverty, malnutrition, political conflicts, lack or poor implementation of mental health policy, poor governance in mental health and health systems, and lower priority for mental health influence the epidemiology, outcomes and treatment strategies of mental health…”
Shaping the future of inflammatory bowel disease: a global research agenda for better management and public health response
Solitano, V., Bernstein, C. N., Dotan, I., Dignass, A. U., Domilici, R., Dubinsky, M. C., Gearry, R. B., Hart, A. L., Kaplan, G. G., Ma, C., et al. (2025) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-025-01063-x · Cited by 98 · see citing works
Socioeconomic status, individual behaviors and risk for mental disorders: A Mendelian randomization study
Cai, J., Wei, Z., Chen, M., He, L., Wang, H., Li, M., & Peng, Y. (2022) · European Psychiatry · doi:10.1192/j.eurpsy.2022.18 · Cited by 81 · see citing works
“Mental disorders have become the major contributors to overall morbidity and disability across the globe [1].”
Background
Dual diagnosis of mental illness and substance use disorder and injury in adults recently released from prison: a prospective cohort study
Young, J. T., Heffernan, E., Borschmann, R., Ogloff, J. R. P., Spittal, M. J., Kouyoumdjian, F. G., Preen, D. B., Butler, A., Brophy, L. M., Crilly, J. L., et al. (2018) · The Lancet Public Health · doi:10.1016/s2468-2667(18)30052-5 · Cited by 80 · see citing works
Hippocampal tail volume as a predictive biomarker of antidepressant treatment outcomes in patients with major depressive disorder: a CAN-BIND report
Nogovitsyn, N., Muller, M., de Souza, R. M., Hassel, S., Arnott, S. R., Davis, A. D., Hall, G. B., Harris, J. K., Zamyadi, M., Metzak, P. D., et al. (2019) · Neuropsychopharmacology · doi:10.1038/s41386-019-0542-1 · Cited by 62 · see citing works
A community–based system dynamics approach for understanding factors affecting mental Health and Health seeking behaviors in Beirut and Beqaa regions of Lebanon
Noubani, A., Diaconu, K., Ghandour, L. A., Koussa, M. E., Loffreda, G., & Saleh, S. S. (2020) · Globalization and Health · doi:10.1186/s12992-020-00556-5 · Cited by 58 · see citing works
Global research mapping of substance use disorder and treatment 1971–2017: implications for priority setting
Tran, B. X., Moir, M., Latkin, C. A., Hall, B. J., Nguyen, C. T., Ha, G. H., Nguyen, N. B., Ho, C. S. H., & Ho, R. (2019) · Substance Abuse Treatment Prevention and Policy · doi:10.1186/s13011-019-0204-7 · Cited by 57 · see citing works
“Despite these efforts, gaps in research, training, treatment, service delivery, and capacity building related to substance use disorder are recognized, with greater negative impacts on low-to-middle income countries [20].”
Mental health care and delivery system at Temeke hospital in Dar es Salaam, Tanzania
Ambikile, J. S., & Iseselo, M. K. (2017) · BMC Psychiatry · doi:10.1186/s12888-017-1271-9 · Cited by 51 · see citing works
“Governments in low and middle income countries need to make deliberate efforts to rescue this situation [27].”
BackgroundInfluential
East African HIV care: depression and HIV outcomes
Meffert, S. M., Neylan, T. C., McCulloch, C. E., Maganga, L., Adamu, Y., Kiweewa, F., Maswai, J. K., Owuoth, J., Polyak, C. S., Ake, J. A., et al. (2019) · Cambridge Prisms Global Mental Health · doi:10.1017/gmh.2019.6 · Cited by 49 · see citing works
“Furthermore, studies now advise that co-occurring substance use disorders, do not change the recommendation to treat depression with evidence-based care (Pettinati et al. , 2013; Baingana et al ., 2015; Tolliver & Anton, 2015).”
Cognitive remediation improves executive functions, self-regulation and quality of life in residents of a substance use disorder therapeutic community
Marceau, E. M., Berry, J., Lunn, J., Kelly, P. J., & Solowij, N. (2017) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2017.04.023 · Cited by 48 · see citing works
“Psychiatric comorbidities are common (Baingana et al., 2015), with Borderline Personality Disorder diagnosed in up to 65% of individuals with SUDs (Pennay et al., 2011).”
Regulation of the kynurenine metabolism pathway by Xiaoyao San and the underlying effect in the hippocampus of the depressed rat
Wang, J., Li, X., He, S., Hu, L., Guo, J., Huang, X., Hu, J., Qi, Y.-Q., Chen, B., Shang, D., et al. (2017) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2017.11.037 · Cited by 47 · see citing works
Personality as an intermediate phenotype for genetic dissection of alcohol use disorder
Oreland, L., Lagravinese, G., Toffoletto, S., Nilsson, K. W., Harro, J., Cloninger, C. R., & Comasco, E. (2017) · Journal of Neural Transmission · doi:10.1007/s00702-016-1672-9 · Cited by 47 · see citing works
“To date, there are only four drugs approved by the Food and Drug Administration and four off-label drugs commonly used for AUD, mainly because the putative target(s) and biological underpinnings of AUD are only fragmentarily known (Franck and Jayaram-Lindström 2013; Baingana et al. 2015).”
Background
Mental health training for secondary school teachers in Haiti: a mixed methods, prospective, formative research study of feasibility, acceptability, and effectiveness in knowledge acquisition
Eustache, E., Gerbasi, M. E., Fawzi, M. C. S., Fils-Aimé, J. R., Severe, J., Raviola, G. J., Legha, R. K., Darghouth, S. L., Grelotti, D. J., Thérosmé, T., et al. (2017) · Cambridge Prisms Global Mental Health · doi:10.1017/gmh.2016.29 · Cited by 47 · see citing works
“The health burdens of mental illness in LMICs among children and adolescents are high and youth are especially vulnerable to social structural barriers to care.”
BackgroundInfluentialSelf-citation
Assessing the Mental Health of Brazilian Students Involved in Risky Behaviors
Escobar, D. F. S. S., Noll, P. R. E. S., de Jesus, T. F., & Noll, M. A. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17103647 · Cited by 39 · see citing works
“labor, increased crime, poverty, unemployment, and early mortality, as well as the development of mental health disorders such as depression and schizophrenia [22].”
BackgroundInfluential
Treatments for people living with schizophrenia in Sub‐Saharan Africa: an adapted realist review
Chidarikire, S., Cross, M., Skinner, I., & Cleary, M. L. (2017) · International Nursing Review · doi:10.1111/inr.12391 · Cited by 35 · see citing works
“Very little of the content published in the most reputable psychiatric journals comes from countries outside the developed world and the proportion ‘from low- and middleincome countries is even lower (3.2%)’ (Patel & Kim 2007, p. 77; Baingana et al. 2015).”
BackgroundInfluential
Determinants of substance use among young people attending primary health centers in India
Venkatesh, U., Aparnavi, P., Kaviprawin, M., Durga, R., Pearson, J., Kishore, S., Joshi, H. S., Nair, N., Nisha, B., Agrawal, R., et al. (2024) · Cambridge Prisms Global Mental Health · doi:10.1017/gmh.2024.13 · Cited by 33 · see citing works
“Early substance use can lead to enduring physical, mental and cognitive impacts, elevating the risk of future substance use disorders and associated problems like educational underachieve-ment (Balyakina et al., 2014; Baingana et al., 2015).”
Background
Regulation of the kynurenine/serotonin pathway by berberine and the underlying effect in the hippocampus of the chronic unpredictable mild stress mice
Wang, Q., Sun, Y., Zou, C.-M., Zhang, T.-L., Li, Z., Liu, M., Shi, B.-Y., Shi, S.-S., Yu, C.-Y., & Wei, T. (2022) · Behavioural Brain Research · doi:10.1016/j.bbr.2022.113764 · Cited by 34 · see citing works
Metabolic Enzymes of Cocaine Metabolite Benzoylecgonine
Chen, X., Zheng, X., Zhan, M., Zhou, Z., Zhan, C., & Zheng, F. (2016) · ACS Chemical Biology · doi:10.1021/acschembio.6b00277 · Cited by 32 · see citing works
Clinical Potential of an Enzyme-based Novel Therapy for Cocaine Overdose
Zhang, T., Zheng, X., Zhou, Z., Chen, X., Jin, Z., Deng, J. T., Zhan, C., & Zheng, F. (2017) · Scientific Reports · doi:10.1038/s41598-017-14105-5 · Cited by 31 · see citing works
Sustainable development for global mental health: a typology and systematic evidence mapping of external actors in low-income and middle-income countries
Iemmi, V. (2019) · BMJ Global Health · doi:10.1136/bmjgh-2019-001826 · Cited by 31 · see citing works
“This could favour the establishment of partnerships across sectors while preserving core values in global mental health.”
Reaching into the toolbox: Stem cell models to study neuropsychiatric disorders
Whiteley, J. T., Fernandes, S., Sharma, A., Mendes, A. P. D., Racha, V., Benassi, S. K., & Marchetto, M. C. (2022) · Stem Cell Reports · doi:10.1016/j.stemcr.2021.12.015 · Cited by 30 · see citing works
The ethical, social, and cultural dimensions of screening for mental health in children and adolescents of the developing world
Salamanca‐Buentello, F., Seeman, M. V., Daar, A. S., & Upshur, R. E. G. (2020) · PLoS ONE · doi:10.1371/journal.pone.0237853 · Cited by 30 · see citing works
“Nine of ten C&A with MNSDs in LMICs lack adequate care [17,18].”
Background
Literature on peer-based community physical activity programmes for mental health service users: a scoping review
Tweed, L. M., Rogers, E. N., & Kinnafick, F. (2020) · Health Psychology Review · doi:10.1080/17437199.2020.1715812 · Cited by 31 · see citing works
Oral health interventions for people living with mental disorders: protocol for a realist systematic review
Kenny, A. J., Dickson‐Swift, V., Gussy, M. G., Kidd, S., Cox, D., Masood, M., Azul, D., Chan, C. K. Y., Christian, B., Theobold, J., et al. (2020) · International Journal of Mental Health Systems · doi:10.1186/s13033-020-00357-8 · Cited by 31 · see citing works
Communalistic use of psychoactive plants as a bridge between traditional healing practices and Western medicine: A new path for the Global Mental Health movement
Oña, G., Berrada, A., & Bouso, J. C. (2021) · Transcultural Psychiatry · doi:10.1177/13634615211038416 · Cited by 29 · see citing works
“…another way of colonization (Mills, 2014); as well as the lack of evidence of the efficacy of “evidence-based” practices in LMICs, since most relevant clinical trials were conducted in high-income countries (Baingana et al., 2015; Kieling et al., 2011; Patel & Kim, 2007; Razzouk et al., 2010).”
Background
A systematic review of frameworks for the interrelationships of mental health evidence and policy in low- and middle-income countries
Votruba, N., Ziemann, A., Grant, J., & Thornicroft, G. (2018) · Health Research Policy and Systems · doi:10.1186/s12961-018-0357-2 · Cited by 31 · see citing works
“Other authors focus on setting priorities for research, linking them with principles for context-driven, intersectoral and integrative approaches to change policy and systems in LMICs [146].”
Background
Intervention for alcohol use disorders at an HIV care clinic in Harare: a pilot and feasibility study
Madhombiro, M., Dube, B., Dube, M., Zunza, M., Chibanda, D., Rusakaniko, S., & Seedat, S. (2019) · Addiction Science & Clinical Practice · doi:10.1186/s13722-019-0143-7 · Cited by 25 · see citing works
Toward a Global Roadmap for Precision Medicine in Psychiatry: Challenges and Opportunities
Dalvie, S., Koen, N., McGregor, N. W., O’Connell, K. S., Warnich, L., Ramesar, R., Nievergelt, C. M., & Stein, D. J. (2016) · OMICS A Journal of Integrative Biology · doi:10.1089/omi.2016.0110 · Cited by 27 · see citing works
“In 2010, 7.4% of the total global disease burden was attributable to mental and substance use disorders, and this burden is anticipated to rise (Whiteford et al., 2013), with the highest increases to occur in low- and middle-income countries (LMICs) (Baingana et al., 2015).”
Influential
Factors associated with patient-reported experiences and outcomes of substance use disorder treatment in Cape Town, South Africa
MYERS, B. J., Koch, J. R., Johnson, K., & Harker, N. (2022) · Addiction Science & Clinical Practice · doi:10.1186/s13722-022-00289-3 · Cited by 26 · see citing works
“In this context of scarce treatment resources, every opportunity for SUD treatment requires optimisation through providing appropriate and efective care [21–23].”
Are Computer-Based Treatment Programs Effective at Reducing Symptoms of Substance Misuse and Mental Health Difficulties Within Adults? A Systematic Review
Dugdale, S., Elison, S., Semper, H., Ward, J., & Davies, G. (2019) · Journal of Dual Diagnosis · doi:10.1080/15504263.2019.1652381 · Cited by 26 · see citing works
“Furthermore, these comorbid difficulties may increase risk of relapse, infections and other complications, and social deprivation (Baingana, al ’ Absi, Becker, & Pringle, 2015).”
Background
Diffusion and spillover effects of an evidence-based mental health intervention among peers and caregivers of high risk youth in Sierra Leone: study protocol
Desrosiers, A., Kumar, P., Dayal, A., Alex, L., Akram, A., & Betancourt, T. S. (2020) · BMC Psychiatry · doi:10.1186/s12888-020-02500-8 · Cited by 24 · see citing works
Association between Sleep Duration, Physical Activity, and Mental Health Disorders: A Secondary Analysis of the National Survey of Children’s Health 2017‐2018
Xiang, S., Dong, J., Li, X., & Li, L. (2021) · BioMed Research International · doi:10.1155/2021/5585678 · Cited by 25 · see citing works
“7 percent of the global disability-life years (YLDs) [1].”
Background
Effectiveness of a Cocaine Hydrolase for Cocaine Toxicity Treatment in Male and Female Rats
Zheng, X., Zhou, Z., Zhang, T., Jin, Z., Chen, X., Deng, J. T., Zhan, C., & Zheng, F. (2017) · The AAPS Journal · doi:10.1208/s12248-017-0167-4 · Cited by 24 · see citing works
Silencing synaptic MicroRNA‐411 reduces voluntary alcohol consumption in mice
Most, D., Salem, N. A., Tiwari, G. R., Blednov, Y. A., Mayfield, R. D., & Harris, R. A. (2018) · Addiction Biology · doi:10.1111/adb.12625 · Cited by 22 · see citing works
“Given the genetic complexity of AUD, it is not surprising that only a few pharmacotherapies have been identified for treating dependence and preventing relapse (World Health Organization 2014; Baingana et al. 2015).”
Background
Priorities for addressing substance use disorder in humanitarian settings
Greene, M. C., Haddad, S., Busse, A., Ezard, N., Ventevogel, P., Demis, L. Y., Inoue, S., Gumm, J.-C., Campello, G., Tol, W. A., et al. (2021) · Conflict and Health · doi:10.1186/s13031-021-00407-z · Cited by 20 · see citing works
Advancing Implementation Science Measurement for Global Mental Health Research
Murphy, J., Maulik, P. K., Dobson, K. S., Govia, I., Lam, R. W. M., Mahlke, C., Mueller‐Stierlin, A. S., Petrea, I., Ventura, C. A. A., & Pearson, M. (2022) · The Canadian Journal of Psychiatry · doi:10.1177/07067437221078411 · Cited by 20 · see citing works
“Challenges contributing to the severity and complexity of the mental health implementation gap include social determinants of mental health,(2) the impact of stigma,(3) limited engagement and participation of key stakeholders including service users,(4) and the need for improved mental health measurement and data coll…”
Background
Human rights and mental health in post-apartheid South Africa: lessons from health care professionals working with suicidal inmates in the prison system
Bantjes, J. R., Swartz, L. M., & Niewoudt, P. (2017) · BMC International Health and Human Rights · doi:10.1186/s12914-017-0136-0 · Cited by 21 · see citing works
“This activism and advocacy is arguably part of good mental health practice in all contexts [52, 53], but is possibly especially important in contexts, like South Africa, where resources are scarce [54].”
Background
Causal associations between female reproductive behaviors and psychiatric disorders: a lifecourse Mendelian randomization study
Yu, Y., Hou, L., Wu, Y., Yu, Y., Liu, X., Wu, S., He, Y., Ge, Y., Wei, Y., Qian, F., et al. (2023) · BMC Psychiatry · doi:10.1186/s12888-023-05203-y · Cited by 17 · see citing works
“Psychiatric disorders have become the major contributors to overall morbidity and disability across the globe [1].”
Background
Burden of post-traumatic stress disorder acute exacerbations during the commemorations of the genocide against Tutsis in Rwanda: a cross-sectional study
Kabakambira, J. D., Uwera, G., Hategeka, M., Kayitesi, M. L., Kalala Malu, C. K., & Hategeka, C. (2018) · Pan African Medical Journal · doi:10.11604/pamj.2018.30.216.15663 · Cited by 16 · see citing works
Global Child Mental Health Research: Time for the Children
Weine, S. M., Marques, A. H., Singh, M., & Pringle, B. (2020) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2020.06.015 · Cited by 16 · see citing works
Self-citation
“The Chicken or the Egg”: Barriers and Facilitators to Collaborative Care for People With Comorbidity in a Metropolitan Region of South Australia
Grønkjær, M., de Crespigny, C., Liu, D., Moss, J. R., Cairney, I., Lee, D., Procter, N. G., & Galletly, C. A. (2016) · Issues in Mental Health Nursing · doi:10.1080/01612840.2016.1233596 · Cited by 15 · see citing works
“The health burden of mental health disorders is exacerbated by the growing concurrent problems associated with substance misuse (Baingana et al., 2015).”
BackgroundInfluential
South African service users’ perceptions of patient‐reported outcome and experience measures for adolescent substance use treatment: A qualitative study
MYERS, B. J., Johnson, K., Lucas, W. C., Govender, R., Manderscheid, R., Williams, P. P., & Koch, J. R. (2019) · Drug and Alcohol Review · doi:10.1111/dar.12996 · Cited by 14 · see citing works
Level of khat dependence, use patterns, and psychological correlates in Yemen: a cross-sectional investigation
Nakajima, M., Hoffman, R., & Al’Absi, M. (2017) · Eastern Mediterranean Health Journal · doi:10.26719/2017.23.3.161 · Cited by 14 · see citing works
“The burden of addiction and mental health problems continues to increase globally (1,2).”
BackgroundSelf-citation
Neurological signs as early determinants of dementia and predictors of mortality among older adults in Latin America: a 10/66 study using the NEUROEX assessment
Pasquini, L., Guerra, J. L., Prince, M. J., Chua, K., & Prina, M. A. (2018) · BMC Neurology · doi:10.1186/s12883-018-1167-4 · Cited by 14 · see citing works
Retrospective evaluation of novel serum inflammatory biomarkers in first-episode psychiatric disorders: diagnostic potential and immune dysregulation
(2024) · doi:10.3389/fpsyt.2024.1442954 · Cited by 15 · see citing works
Just-in-time adaptive interventions for adolescent and young adult health and well-being: protocol for a systematic review
Guan, K., Adlung, C., Keijsers, L., Smit, C. R., Vreeker, A., Thalassinou, E., van Roekel, E., de Reuver, M., & Figueroa, C. A. (2024) · BMJ Open · doi:10.1136/bmjopen-2024-083870 · Cited by 13 · see citing works
Prevalence of physical health conditions and health risk behaviours in people with severe mental illness in South Asia: protocol for a cross-sectional study (IMPACT SMI survey)
Zavala, G. A., Prasad-Muliyala, K., Aslam, F., Barua, D., Chowdhury, A. H., Hewitt, C. E., Huque, R., Mansoor, S., Murthy, P., Nizami, A. T., et al. (2020) · BMJ Open · doi:10.1136/bmjopen-2020-037869 · Cited by 13 · see citing works
Global priorities of civil society for mental health services: findings from a 53 country survey
Copeland, J. R. M., Thornicroft, G., Bird, V., Bowis, J., & Slade, M. (2014) · World Psychiatry · doi:10.1002/wps.20133 · Cited by 13 · see citing works
Formative research on a teacher accompaniment model to promote youth mental health in Haiti: Relevance to mental health task-sharing in low-resource school settings
Eustache, E., Gerbasi, M. E., Severe, J., Fils-Aimé, J. R., Fawzi, M. C. S., Raviola, G. J., Darghouth, S. L., Boyd, K., Thérosmé, T., Legha, R. K., et al. (2017) · International Journal of Social Psychiatry · doi:10.1177/0020764017700173 · Cited by 13 · see citing works
Self-citation
An adaptive design to screen, treat, and retain people with opioid use disorders who use methamphetamine in methadone clinics (STAR-OM): study protocol of a clinical trial
Giang, L. M., Trang, N. T., Diệp, N. B., Thuy, D. T. D., Thuy, D. T., Hòe, H. Đ., Vân, H. T. H., Thai, T. T., Nguyen, H. H., Lai, N. L., et al. (2022) · Trials · doi:10.1186/s13063-022-06278-w · Cited by 13 · see citing works
“In low-and-middle-income countries, it is vital to identify cost-effective models of adapted evidence-based practices for addressing substance use disorders [19, 20].”
Background
Cebranopadol reduces cocaine self-administration in male rats: Dose, treatment and safety consideration
Wei, H., Zhang, T., Zhan, C., & Zheng, F. (2020) · Neuropharmacology · doi:10.1016/j.neuropharm.2020.108128 · Cited by 12 · see citing works
Psychosocial and pharmacologic interventions to reduce harmful alcohol use in low- and middle-income countries
Greene, M. C., Kane, J., Alto, M., Giusto, A., Lovero, K., Stockton, M., McClendon, J., Nicholson, T., Wainberg, M. L., Johnson, R. M., et al. (2023) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd013350.pub2 · Cited by 11 · see citing works
Heterogeneous Effects of Obesity on Life Expectancy: A Global Perspective
Bansal, S., & Jin, Y. (2023) · Annual Review of Resource Economics · doi:10.1146/annurev-resource-022823-033521 · Cited by 13 · see citing works
Income Disparity and Mental Wellbeing among Adults in Semi-Urban and Rural Areas in Malaysia: The Mediating Role of Social Capital
Said, M. A., Thangiah, G., Majid, H. A., İsmail, R., Tan, M. P., Rizal, H., Zaidi, M. A. S., Reidpath, D. D., & Su, T. T. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19116604 · Cited by 11 · see citing works
Use of sequence analysis for classifying individual antidepressant trajectories to monitor population mental health
Cherrie, M. P. C., Curtis, S. E., Baranyi, G., McTaggart, S., Cunningham, N., Licence, K. A. M., Dibben, C. J. L., Bambra, C. L., & Pearce, J. R. (2020) · BMC Psychiatry · doi:10.1186/s12888-020-02952-y · Cited by 10 · see citing works
The Development of Bacterial Carboxylesterase Biological Recognition Elements for Cocaine Detection
Mustafa, S. A. (2018) · Molecular Biotechnology · doi:10.1007/s12033-018-0098-z · Cited by 10 · see citing works
Psychoactive substances for the treatment of neuropsychiatric disorders
Zhen, Z., Sun, X., Yuan, S., & Zhang, J. (2024) · Asian Journal of Psychiatry · doi:10.1016/j.ajp.2024.104193 · Cited by 9 · see citing works
Global, regional, and national burden of mental disorders and substance use disorders in older adults from 1990 to 2021: a systematic analysis and future trend prediction study
Gao, Y., Zhou, W., Wang, Q., Zhai, Q., & Zhou, L. (2025) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2025.1638646 · Cited by 10 · see citing works
“Our ﬁ ndings on extreme health burdens in Uganda and Belarus align with Baingana et al. ’ s (23)projection that low-and middle-income countries will experience the steepest rise in mental disease and SUDs burden due to increasing life expectancy, population growth, and under-resourced healthcare…”
Brain Theranostics and Radiotheranostics: Exosomes and Graphenes In Vivo as Novel Brain Theranostics
Suh, M., & Lee, D. S. (2018) · Nuclear Medicine and Molecular Imaging · doi:10.1007/s13139-018-0550-9 · Cited by 8 · see citing works
Perspectives of people experiencing homelessness with recent non-fatal street drug overdose on the Pharmacist and Homeless Outreach Engagement and Non-medical Independent prescribing Rx (PHOENIx) intervention
Farmer, N., McPherson, A., Thomson, J., & Lowrie, R. (2024) · PLoS ONE · doi:10.1371/journal.pone.0302988 · Cited by 8 · see citing works
Epigenetic Drugs for Mood Disorders
Peedicayil, J., & Kumar, A. (2018) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2018.01.005 · Cited by 8 · see citing works
Global mental health and the treatment gap: A human rights and neuroethics concern
Herrera-Ferrá, K. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-815063-4.00009-5 · Cited by 8 · see citing works
Where there is no evidence: implementing family interventions from recommendations in the NICE guideline 11 on challenging behaviour in a South African health service for adults with intellectual disability
Coetzee, O., Swartz, L. M., Capri, C., & Adnams, C. M. (2019) · BMC Health Services Research · doi:10.1186/s12913-019-3999-z · Cited by 7 · see citing works
Effectiveness of eHealth Technology–Based Interventions in Reducing Substance Misuse Among Older Adults: A Systematic Review
Kazemi, D. M., Troutman‐Jordan, M., Whitfield, J. E., & Pappa, E. V. (2021) · Journal of Gerontological Nursing · doi:10.3928/00989134-20210908-04 · Cited by 7 · see citing works
Evaluation of the Antidepressant Activity of Beta vulgaris Alone and in Combination with Fluoxetine in Mice
Invally, M., Kaur, G., & Buttar, H. S. (2016) · Journal of Pharmacology and Toxicology · doi:10.3923/jpt.2017.33.41 · Cited by 7 · see citing works
Health insurance expansion and family violence prevention: A conceptual framework
Letourneau, E. J., Assini‐Meytin, L. C., Nair, R., Stuart, E. A., Decker, M. R., & McGinty, E. B. (2022) · Child Abuse & Neglect · doi:10.1016/j.chiabu.2022.105664 · Cited by 6 · see citing works
Success4life Youth Empowerment for Promoting Well-being and Boosting Mental Health: Protocol for an Experimental Study
Setia, S., Furtner, D., Bendahmane, M., & Tichy, M. L. (2022) · JMIR Research Protocols · doi:10.2196/38463 · Cited by 9 · see citing works
“A bidirectional relationship exists between mental disorders and excessive social media use, substance use, and drug dependence, leading to a vicious cycle impacting youth across all communications and countries [4-7].”
Psychosocial and pharmacologic interventions to reduce harmful alcohol use in low- and middle-income countries
Greene, M. C., Kane, J. C., Johnson, R. M., & Tol, W. A. (2019) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd013350 · Cited by 7 · see citing works
Integrated decision-making model for community-based rehabilitation service utilisation among persons with severe mental illness in China: protocol for a cross-sectional, mixed-methods study
Wang, R., Tang, S., SHAW, I. F., Feng, Z., Chen, Z., Luo, Y., Song, H., Wu, T., Fu, Q., Fu, H., et al. (2018) · BMJ Open · doi:10.1136/bmjopen-2018-021528 · Cited by 6 · see citing works
Antidepressant Potentials of Aqueous Extract of Voacanga africana stept. ex Eliot (Apocynaceae) Stem Bark
Owolabi, T. A., Ezenwa, K. C., Amodu, E., Iyoriobhe, O. C., Okubor, P., Aigbe, D. P., & Okogun, J. I. (2019) · International Journal of Current Microbiology and Applied Sciences · doi:10.20546/ijcmas.2019.812.306 · Cited by 6 · see citing works
“In South Asia, including India, more than 50% of all the mental health related DALYs are related to depression (Baingana et al., 2015).”
Background
Integration of substance use disorder treatment in traditional mental health facilities: Timeseries and cross-sectional evaluations
Garrison, Y. L., Luo, Y., & Sahker, E. (2024) · International Journal of Drug Policy · doi:10.1016/j.drugpo.2023.104312 · Cited by 5 · see citing works
Patterns of Pulmonary Consultation for Veterans with Incident Chronic Obstructive Pulmonary Disease
Núñez, E., Johnson, S. W., Qian, S. X., Powell, W. R., Walkey, A. J., Wiener, R. S., & Rinne, S. T. (2021) · Annals of the American Thoracic Society · doi:10.1513/annalsats.202008-1075rl · Cited by 5 · see citing works
Antidepressant prescriptions and therapy intensification in men and women newly diagnosed with depression in the UK
John, D., Montvida, O., Chin, K. L., Khunti, K. K., & Paul, S. K. (2022) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2022.06.054 · Cited by 5 · see citing works
A Systematic Review and Narrative Synthesis of Interventions to Address Substance Use Disorders and Other Mental Health Disorders in Prison Settings With a Focus on Low- and Middle-Income Countries
Jordan, A. E., Kashino, W., Suhartono, S., Campello, G., & Busse, A. (2023) · Criminal Justice and Behavior · doi:10.1177/00938548231166155 · Cited by 4 · see citing works
“The available evidence-base of efficacious and effective interventions for the treatment of SUDs and other MHDs derives from studies conducted in high-resourced settings (Baingana et al., 2015; Zielinski et al., 2020).”
BackgroundInfluential
Chronic substance use and self-harm in a primary health care setting
Breet, E., Bantjes, J. R., & Lewis, I. (2018) · African Journal of Primary Health Care & Family Medicine · doi:10.4102/phcfm.v10i1.1544 · Cited by 5 · see citing works
A case study of the development of a valid and pragmatic implementation science measure: the Barriers and Facilitators in Implementation of Task-Sharing Mental Health interventions (BeFITS-MH) measure
Yang, L. H., Bass, J. K., Le, P. D., Singh, R., Gurung, D., Velasco, P. R., Grivel, M. M., Susser, E., Cleland, C. M., Alvarado, R., et al. (2024) · BMC Health Services Research · doi:10.1186/s12913-024-11783-6 · Cited by 4 · see citing works
“…a robust understanding of the barriers and facilitators that contribute to implementation success and what these look like across diverse task-sharing mental health interventions and contexts, which is needed to fulfill the promise of task-sharing in addressing the mental health treatment gap [29].”
Background
Associations between greenspace characteristics and population emotion perceptions in three dimensions
Cao, Z., Cao, Y., & Wu, Z. (2023) · Frontiers in Environmental Science · doi:10.3389/fenvs.2023.1228717 · Cited by 5 · see citing works
Understanding African American/Black and Latine young and emerging adults living with HIV: a sequential explanatory mixed methods study focused on self-regulatory resources
Wilton, L., Gwadz, M. V., Cleland, C. M., Campos, S., Munson, M. R., Dorsen, C. G., Serrano, S., Sherpa, D., Saba, S. K., Rosmarin-DeStefano, C. L., et al. (2025) · International Journal for Equity in Health · doi:10.1186/s12939-025-02492-5 · Cited by 4 · see citing works
“We also highlight mental health distress, which commonly co-occurs with, and can be a cause or a consequence of substance use [23, 24].”
Mental Health Promotion Through Collection Of Global Opinion Data
Seeman, N., Fogler, S., & Seeman, M. V. (2016) · Journal of Preventive Medicine And Care · doi:10.14302/issn.2474-3585.jpmc-16-1112 · Cited by 4 · see citing works
Leave no one behind: integrated sexual and reproductive, mental health and psychosocial programming for not in employment, education or training (NEET) adolescents and youth in sub-Saharan Africa
Kumar, M., Mutahi, J., & Kangwana, B. P. (2023) · BMJ Global Health · doi:10.1136/bmjgh-2023-013394 · Cited by 4 · see citing works
“22 23 Several studies have also pointed out issues such as missed opportunities and delays in addressing NEET raised concerns around quality and affordable education in children and youth as promised by countries following global SDG commitment.”
Background
An Empirical Analysis of Structural Neuroimaging Profiles in a Staging Model of Depression
Nogovitsyn, N., Ballester, P. L., Lasby, M., Dunlop, K., Ceniti, A. K., Squires, S. D., Rowe, J., Ho, K. T., Suh, J. S., Hassel, S., et al. (2022) · Journal of Affective Disorders · doi:10.1016/j.jad.2024.01.246 · Cited by 5 · see citing works
Clustering of methamphetamine users based on personality characteristics and self-efficacy in the west of Iran
Jouybari, T. A., Zakiei, A., Salemi, S., Lak, Z., Mohebian, M., Castaldelli-Maia, J. M., Bajoghli, H., Hookari, S., & Kamani, M. (2024) · Scientific Reports · doi:10.1038/s41598-024-66673-y · Cited by 4 · see citing works
Bioculture and the global regulatory gap in neuroscience, neurotechnology, and neuroethics
Herrera-Ferrá, K. (2021) · Developments in neuroethics and bioethics · doi:10.1016/bs.dnb.2021.08.001 · Cited by 4 · see citing works
Development of national capabilities in low and middle income countries for research in child mental health
Polanczyk, G. V. (2016) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-016-0818-5 · Cited by 4 · see citing works
“The challenges and opportunities ahead are significant [3, 12], but the scientific synergies created by networks, mentoring, and research collaborations have huge potentials to promote learning, growth and development, for all parties involved.”
Background
The influence of past experiences, psychological dysfunction, and problematic mentalities: An investigation into the comprehensive nature of drink-driving deterrence
Love, S., Rowland, B., & Larue, G. S. (2025) · Journal of Safety Research · doi:10.1016/j.jsr.2025.06.013 · Cited by 3 · see citing works
Exploring Naturalistic Diffusion of an Evidence-Based Mental Health Intervention across Peer Networks of Youth in Sierra Leone
Desrosiers, A., Bond, L., Hoffman, M., Kumar, P., Schafer, C., Metzger, I. W., Vandi, A., Hinton, M., & Betancourt, T. S. (2023) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph20054059 · Cited by 3 · see citing works
“The key components of personal networks include the following: (1) a focal node (respondent), (2) peers reported by the respondents, and (3) the ties between the respondent and their peers [3].”
SANTÉ PSYCHIQUE, MAL-ÊTRE, DÉPRESSION ET ANXIÉTÉ DES ÉTUDIANTS : DES CHIFFRES ET DES HUMAINS?
Morvan, Y., Frajerman, A., Kern, L., & Chaumette, B. (2019) · Revue québécoise de psychologie · doi:10.7202/1065901ar · Cited by 3 · see citing works
Economic Burden of Mental Disorders in Bangladesh: A Systematic Review and Recommendations for Future ResearchPreprint
Rodela, T. T., Tasnim, S., Mazumder, H., Sharmin, D. F., Faizah, F., Sultana, A., & Hossain, M. M. (2020) · doi:10.31235/osf.io/mq9au · Cited by 3 · see citing works
Cognitive remediation improves executive functions, self-regulation and quality of life in residents of a substance use disorder therapeutic community
Marceau, E. M. (2017) · doi:10.26226/morressier.5971be87d462b80290b532e8 · Cited by 3 · see citing works
Sex differences in the associations of non-medical use of prescription drugs with depressive and anxiety symptoms among undergraduates in China
Hua, Y., Shi, G., Zheng, X., Huang, C., Xu, Y., Huang, G., Wang, W., Lu, C., & Guo, L. (2023) · Journal of Affective Disorders · doi:10.1016/j.jad.2023.04.002 · Cited by 2 · see citing works
Effect of Work-Life Balance, Telecommuting, Job Satisfaction, Sleep Duration, and Stress Management on the Physical and Mental Health of Overseas Workers in Jakarta
Iswahyudi, M. S. (2023) · West Science Interdisciplinary Studies · doi:10.58812/wsis.v1i02.46 · Cited by 2 · see citing works
Assessing the Efficacy of Mental Health Assessment Training for Accredited Social Health Activists Workers in Rural India: A Pilot Study
Kasturkar, P., Sebastian, S. T., Dukare, K. P., Gawai, J. P., Uke, T., & Wanjari, M. B. (2023) · Cureus · doi:10.7759/cureus.37855 · Cited by 2 · see citing works
“Several studies have demonstrated the potential for mHealth technologies to support mental health service delivery in LMICs [15].”
BackgroundInfluential
Menjembatani Kesenjangan dalam Perawatan Kesehatan Mental: Pendekatan Baru untuk Diagnosis, Pengobatan, dan Pengurangan Stigma
Setiawan, C. T., Sijabat, S. G., Ervan, & Habibi, H. (2023) · Jurnal Multidisiplin West Science · doi:10.58812/jmws.v2i08.579 · Cited by 2 · see citing works
Towards Data-Driven Artificial Intelligence Models for Monitoring, Modelling and Predicting Illicit Substance Use
Mbunge, E., Batani, J., Chitungo, I. J. B., Moyo, E., Musuka, G., Muchemwa, B., & Dzinamarira, T. (2024) · Lecture notes in networks and systems · doi:10.1007/978-3-031-54820-8_29 · Cited by 2 · see citing works
A Case Study of the Development of a Valid and Pragmatic Implementation Science Measure: The Barriers and Facilitators in Implementation of Task-Sharing Mental Health Interventions (BeFITS-MH) MeasurePreprint
Yang, L. H., Bass, J. K., Le, P. D., Singh, R., Gurung, D., Velasco, P. R., Grivel, M. M., Susser, E., Cleland, C. M., Alvarado, R., et al. (2024) · Research Square · doi:10.21203/rs.3.rs-3877031/v1 · Cited by 2 · see citing works
“…a robust understanding of the barriers and facilitators that contribute to implementation success and what these look like across diverse task-sharing mental health interventions and contexts, which is needed to ful�ll the promise of task-sharing in addressing the mental health treatment gap (29).”
Background

Research task shifting and youth as drivers of a more global mental health science
Amarasekera, S., Ugo, V., Florez, V., & Patalay, P. (2021) · The Lancet Psychiatry · doi:10.1016/s2215-0366(21)00368-0 · Cited by 2 · see citing works
Research Priorities, Capacity, and Networks in Global Mental Health
Collins, P. Y., Tomlinson, M., Kakuma, R., Awuba, J., & Minas, H. (2013) · Oxford University Press eBooks · doi:10.1093/med/9780199920181.003.0019 · Cited by 16 · see citing works
From delivery science to discovery science: realising the full potential of global mental health
Patel, V. (2016) · Epidemiology and Psychiatric Sciences · doi:10.1017/s2045796016000263 · Cited by 11 · see citing works
Expanding access to mental health care: a missing ingredient
Jack, H. E., Stein, A. L., Newton, C. R. J. C., & Hofman, K. J. (2014) · The Lancet Global Health · doi:10.1016/s2214-109x(14)70029-4 · Cited by 16 · see citing works
Mental Health Research in the Global Era: Training the Next Generation
Sweetland, A. C., Oquendo, M. A., Carlson, C., Magidson, J. F., & Wainberg, M. L. (2015) · Academic Psychiatry · doi:10.1007/s40596-015-0437-3 · Cited by 25 · see citing works

Authors: Baingana, F., al'Absi, M., Becker, A. E., & Pringle, B.
Affiliations: Makerere University (UG)
Harvard University (US)
National Institute of Mental Health (US)
Corresponding author: Baingana, Florence
ORCID: Baingana, Florence
Becker, Anne E.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2015-11-18
Volume: 527
Issue: 7578
Pages: S172-S177
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature16032
PMC: PMC6368440
OpenAlex: W2176845058
Cited by: 138
References: 66
Citations by year: 2026: 11 · 2025: 11 · 2024: 15 · 2023: 17 · 2022: 14 · 2021: 8 · 2020: 14 · 2019: 15 · 2018: 12 · 2017: 12 · 2016: 7 · 2015: 1 · 2014: 1
FWCI: 1.66
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0 (tdm)
creativecommons.org/licenses/by/4.0 (vor)
Locations: Nature (publishedVersion, cc-by)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion, cc-by)
PubMed Central (acceptedVersion, cc-by)
RePEc: Research Papers in Economics (submittedVersion)
Funders: Grand Challenges Canada
National Institute of Mental Health
National Institute on Drug Abuse (R21DA024626, R01DA016351, R01DA027232)
Fogarty International Center
Topics: Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
Social Sciences › Psychology › Clinical Psychology › Migration, Health and Trauma
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Global Health and Surgery
Keywords: global mental health, substance use disorders, low- and middle-income countries, implementation research, service delivery adaptation, research capacity building, multimorbidity, life course, health equity, multisectoral approach, integrative care, access to mental health care
MeSH terms: Delivery of Health Care, Humans, Mental Health, Substance-Related Disorders, Biomedical Research, Internationality

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Global research challenges and opportunities for mental health and substance-use disorders

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks