Protein misfolding in the endoplasmic reticulum as a conduit to human disease

Control of inositol 1,4,5-trisphosphate-induced Ca2+ release by cytosolic Ca2+

Bootman, M. D., Missiaen, L., Parys, J. B., SMEDT, H. D., & Casteels, R. (1995) · Biochemical Journal · doi:10.1042/bj3060445 · Cited by 5,131

The unfolded protein response: controlling cell fate decisions under ER stress and beyond

Hetz, C. A. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3270 · Cited by 4,223

Endoplasmic Reticulum Stress Links Obesity, Insulin Action, and Type 2 Diabetes

Özcan, U., Cao, Q., Yilmaz, E., Lee, A.-H., Iwakoshi, N. N., Özdelen, E., Tuncman, G., Görgün, C., Glimcher, L. H., & Hotamisligil, G. S. (2004) · Science · doi:10.1126/science.1103160 · Cited by 3,844

THE MAMMALIAN UNFOLDED PROTEIN RESPONSE

Schröder, M., & Kaufman, R. J. (2005) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.73.011303.074134 · Cited by 3,099

CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulumPreprint

Marciniak, S. J., Yun, C. Y., Oyadomari, S., Novoa, I., Zhang, Y., Jungreis, R., Nagata, K., Harding, H. P., & Ron, D. (2004) · Genes & Development · doi:10.1101/gad.1250704 · Cited by 2,066

CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulumPreprint

Zinszner, H., Kuroda, M., Wang, X., Batchvarova, N., Lightfoot, R. T., Remotti, H. E., Stevens, J. L., & Ron, D. (1998) · Genes & Development · doi:10.1101/gad.12.7.982 · Cited by 2,039

From endoplasmic-reticulum stress to the inflammatory response

Zhang, K., & Kaufman, R. J. (2008) · Nature · doi:10.1038/nature07203 · Cited by 2,010

Reactive Oxygen Species Promote TNFα-Induced Death and Sustained JNK Activation by Inhibiting MAP Kinase Phosphatases

Kamata, H., Honda, S.-I., Maeda, S., Chang, L., Hirata, H., & Karin, M. (2005) · Cell · doi:10.1016/j.cell.2004.12.041 · Cited by 1,792

ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death

Han, J., Back, S. H., Hur, J., Lin, Y.-H., Gildersleeve, R., Shan, J., Yuan, C. L., Krokowski, D., Wang, S., Hatzoglou, M., et al. (2013) · Nature Cell Biology · doi:10.1038/ncb2738 · Cited by 1,691

XBP1 Links ER Stress to Intestinal Inflammation and Confers Genetic Risk for Human Inflammatory Bowel Disease

Kaser, A., Lee, A., Franke, A., Glickman, J. N., Zeißig, S., Tilg, H., Nieuwenhuis, E. E. S., Higgins, D. E., Schreiber, S., Glimcher, L. H., et al. (2008) · Cell · doi:10.1016/j.cell.2008.07.021 · Cited by 1,465

The PERK pathway: beneficial or detrimental for neurodegenerative diseases and tumor growth and cancer

Talukdar, G., Orr, H. T., & Lei, Z. (2023) · Human Molecular Genetics · doi:10.1093/hmg/ddad103 · Cited by 12

The Emerging Role of Sigma Receptors in Pain Medicine

Pergolizzi, J. V., & Varrassi, G. (2023) · Cureus · doi:10.7759/cureus.42626 · Cited by 11

Endoplasmic reticulum stress: a vital process and potential therapeutic target in chronic obstructive pulmonary disease

Peng, H., Zhou, Q., Liu, J., Wang, Y., Mu, K., & Zhang, L. (2023) · Inflammation Research · doi:10.1007/s00011-023-01786-0 · Cited by 11

Lithium ameliorates spinal cord injury through endoplasmic reticulum stress-regulated autophagy and alleviated apoptosis through IRE1 and PERK/eIF2α signaling pathways

Wang, F., Zhang, C., Zhang, Q., Li, J., Xue, Y., He, X., & Li, F. (2023) · Journal of Neurorestoratology · doi:10.1016/j.jnrt.2023.100081 · Cited by 12

Kaempferol attenuates particle-induced osteogenic impairment by regulating ER stress via the IRE1α–XBP1s pathway

Yu, X., Ren, Z., Wang, Y., Yuan, G., Hu, J., Song, L., Pan, C., Feng, K., Liu, Y., Shao, L., et al. (2024) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2024.107394 · Cited by 11

Homeostatic interplay between FoxO proteins and ER proteostasis in cancer and other diseases

González-Quiroz, M., Urra, H., Limia, C. M., & Hetz, C. A. (2018) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2018.01.011 · Cited by 11

Fluorescent detection of peroxynitrite during antibody-dependent cellular phagocytosis

Rane, D., Carlson, E. J., Yin, Y., & Peterson, B. R. (2020) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/bs.mie.2020.04.001 · Cited by 11

Cellular senescence and tumor promotion: Role of the Unfolded Protein Response

Pluquet, O., & Abbadie, C. (2021) · Advances in cancer research · doi:10.1016/bs.acr.2021.01.001 · Cited by 12

Insights into Exosome in the Intervertebral Disc: Emerging Role for Disc Homeostasis and Normal Function

Zhao, X., Xu, B., Duan, W., Chang, L., Tan, R., Sun, Z., & Ye, Z. (2022) · International Journal of Medical Sciences · doi:10.7150/ijms.75285 · Cited by 11

Nrf2 dictates the neuronal survival and differentiation of embryonic zebrafish harboring compromised alanyl-tRNA synthetase

Jin, B., Xie, L., Zhan, D., Zhou, L., Feng, Z. W., He, J., Qin, J., Zhao, C., Luo, L., & Li, L. (2022) · Development · doi:10.1242/dev.200342 · Cited by 10

Geniposide attenuates spermatogenic dysfunction via inhibiting endoplasmic reticulum stress in male mice

Chi, Y.-N., Ye, R.-J., Yang, J., Hai, D.-M., Liu, N., Ren, J.-W., Du, J., Lan, X., Yu, J., & Ma, L. (2022) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2022.110144 · Cited by 10

Molecular and Functional Characteristics of Airway Epithelium under Chronic Hypoxia

Wong, S. L., Kardia, E., Vijayan, A., Umashankar, B., Pandžić, E., Zhong, L., Jaffé, A., & Waters, S. A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24076475 · Cited by 11

Ajugol's upregulation of TFEB-mediated autophagy alleviates endoplasmic reticulum stress in chondrocytes and retards osteoarthritis progression in a mouse model

Wu, J., Yu, H., Jin, Y., Wang, J., Zhou, L., Cheng, T., Zhang, Z., Lin, B., Miao, J., & Lin, Z. (2023) · Chinese Medicine · doi:10.1186/s13020-023-00824-7 · Cited by 10

Protein aggregation and biomolecular condensation in hypoxic environments (Review)

Li, C., Hao, B., Yang, H., Wang, K., Fan, L., & Xiao, W. (2024) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2024.5357 · Cited by 10

SEC16A Variants Predispose to Chronic Pancreatitis by Impairing ER‐to‐Golgi Transport and Inducing ER Stress

Wang, M., Wang, Y., Masson, E., Wang, Y., Yu, D. S., Qian, Y., Tang, X., Deng, S., Hu, L., Wang, L., et al. (2024) · Advanced Science · doi:10.1002/advs.202402550 · Cited by 10

Multidimensional Investigations of Single Molecule Unfolding of Bovine Serum Albumin Using Plasmonic Nanopores

Zhou, J., Gao, C., Ding, Y., Nie, Z., Xu, M., Fu, P., He, B., Wang, S., Xia, X., & Wang, K. (2025) · Nano Letters · doi:10.1021/acs.nanolett.5c01214 · Cited by 10

The hepatitis B virus surface antigen: An evolved perfection and its unresolved mysteries

Bell, J. T., & Zhang, X. (2025) · Virology · doi:10.1016/j.virol.2025.110527 · Cited by 10

Advancing nephroprotective strategies: the role of naringenin in preventing gentamicin-induced nephrotoxicity

Bwambale, W., Oka, V. O., Onaadepo, O., Etukudo, E. M., Owu, D. U., Nkanu, E. E., Shehu, U. U., Bwambale, F., & Geoffrey, A. (2025) · Discover Medicine · doi:10.1007/s44337-025-00315-8 · Cited by 10

Identification of an endoplasmic reticulum stress-related signature associated with clinical prognosis and immune therapy in glioma

Li, L., Yang, Z., Zheng, Y., Chen, Z., Yue, X., Bian, E., & Zhao, B. (2022) · BMC Neurology · doi:10.1186/s12883-022-02709-y · Cited by 10

Identifying a Novel Endoplasmic Reticulum‐Related Prognostic Model for Hepatocellular Carcinomas

Ding, F., Li, J., Zhang, Y., Wang, C., & Yu, Y. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/8248355 · Cited by 10

TMAO to the rescue of pathogenic protein variants

Kumari, K., Singh, K. S., Singh, K., Bakhshi, R., & Singh, L. R. (2022) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2022.130214 · Cited by 10

Endoplasmic Reticulum Stress-Related Signature for Predicting Prognosis and Immune Features in Hepatocellular Carcinoma

Zhang, G., & Sun, J. (2022) · Journal of Immunology Research · doi:10.1155/2022/1366508 · Cited by 10

Diagnostic Potential of microRNAs in Extracellular Vesicles Derived from Bronchoalveolar Lavage Fluid for Pneumonia—A Preliminary Report

Sun, Y., Xian, Y., Duan, Z., Wan, Z., Li, J., Liao, Y., Bi, X., Wang, L., 吴忠道, & Zhang, K. (2022) · Cells · doi:10.3390/cells11192961 · Cited by 10

Molecular Mechanism Underlying Role of the XBP1s in Cardiovascular Diseases

Liu, S., Ding, H., Li, Y.-N., & Zhang, X. (2022) · Journal of Cardiovascular Development and Disease · doi:10.3390/jcdd9120459 · Cited by 7

Protective effect of saffron carotenoids against amyloid b eta‐induced neurotoxicity in differentiated PC12 cells via the unfolded protein response and autophagy

Sanjari‐Pour, M., Faridi, N., Wang, P., & Bathaie, S. Z. (2023) · Phytotherapy Research · doi:10.1002/ptr.7773 · Cited by 10

Protein homeostasis in the aged and diseased heart

Mainali, N., Ayyadevara, S., Ganne, A., Reis, R. J. S., & Mehta, J. L. (2023) · The Journal of Cardiovascular Aging · doi:10.20517/jca.2023.4 · Cited by 10

Hydroquinone‐induced endoplasmic reticulum stress affects TK6 cell autophagy and apoptosis via ATF6‐mTOR

Li, B., Yang, H., Wu, H., Wang, H., Ye, Z., Yao, W., Chen, Y., & Tang, H. (2023) · Environmental Toxicology · doi:10.1002/tox.23814 · Cited by 10

Naphthyridine-Based Electron Push–Pull-Type Amine-Reactive Fluorescent Probe for Sensing Amines and Proteins in Aqueous Media

Umeno, T., Muroi, L., Kayama, Y., Usui, K., Hamada, K., Mizutani, A., & Karasawa, S. (2023) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.3c00220 · Cited by 10

Population pharmacokinetic model for oral ORIN1001 in Chinese patients with advanced solid tumors

Li, X., Bo, Y., Zeng, Q., Diao, L., Greene, S., Patterson, J. B., Liu, L., & Yang, F. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1322557 · Cited by 10

Fluoride exposure during puberty induces testicular impairment via ER stress-triggered apoptosis in mice

Wang, R., Gong, W., Jiang, Y., Yin, Q., Wang, Z., Wu, J., Zhang, M., Li, M., Liu, Y., Wang, J., et al. (2024) · Food and Chemical Toxicology · doi:10.1016/j.fct.2024.114773 · Cited by 10

PAT exposure caused human hepatocytes apoptosis and induced mice subacute liver injury by activating oxidative stress and the ERS-associated PERK pathway

Zhang, H., Tang, M., Liu, Q., Wu, D., Sun, B., Dong, J., Guan, L., Luo, J., & Zeng, M. (2024) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2024.177003 · Cited by 10

Plasminogen Tochigi mice exhibit phenotypes similar to wild-type mice under experimental thrombotic conditions

Tashima, Y., Banno, F., Kita, T., Matsuda, Y., Yanamoto, H., & Miyata, T. (2017) · PLoS ONE · doi:10.1371/journal.pone.0180981 · Cited by 10

Coordinating Organismal Metabolism During Protein Misfolding in the ER Through the Unfolded Protein Response.

Chandrahas, V. K., Han, J., & Kaufman, R. (2018) · Current Topics in Microbiology and Immunology · doi:10.1007/82_2017_41 · Cited by 11

Immobilization stress induces XBP1 splicing in the mouse brain

Hosoi, T., Kimura, H., Yamawaki, Y., Mori, K., & Ozawa, K. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.11.167 · Cited by 10

Saved by the Matrix: UPR Independent Survival under ER Stress

Koopman, M., Hetz, C. A., & Nollen, E. A. A. (2019) · Cell · doi:10.1016/j.cell.2019.11.012 · Cited by 10

Cucurbitacin E Induces Autophagy-Involved Apoptosis in Intestinal Epithelial Cells

Song, H., Sui, H., Zhang, Q., Wang, P., & Wang, F. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.01020 · Cited by 10

Polybrominated diphenyl ethers quinone-induced intracellular protein oxidative damage triggers ubiquitin-proteasome and autophagy-lysosomal system activation in LO2 cells

Wang, Y., Xu, L., Lü, P., Fang, C., Qi, Q., Lv, X., Liu, Z., Yang, B. V., Song, E., & Song, Y. (2021) · Chemosphere · doi:10.1016/j.chemosphere.2021.130034 · Cited by 10

miR-1307 promotes hepatocarcinogenesis by CALR-OSTC-endoplasmic reticulum protein folding pathway

Xie, S., Jiang, X., Qin, R., Song, S., Lu, Y., Wang, L., Chen, Y., & Lu, D. (2021) · iScience · doi:10.1016/j.isci.2021.103271 · Cited by 10

PKA/ATGL signaling pathway is involved in ER stress-mediated lipolysis in adipocytes of grass carp (Ctenopharyngodon idella)

Ji, S., Sun, J. H., Bian, C., Huang, X., & Ji, H. (2022) · Fish Physiology and Biochemistry · doi:10.1007/s10695-021-01032-6 · Cited by 10

Development of a Photoactivatable Phosphine Probe for Induction of Intracellular Reductive Stress with Single‐Cell Precision

Tirla, A., & Rivera‐Fuentes, P. (2016) · Angewandte Chemie · doi:10.1002/ange.201608779 · Cited by 10

Two common human CLDN5 alleles encode different open reading frames but produce one protein isoform

Cornely, R. M., Schlingmann, B., Shepherd, W. S., Chandler, J. D., Neujahr, D. C., & Koval, M. H. (2017) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13342 · Cited by 10

Development of AD-Like Pathology in Skeletal Muscle

Chen, X., Miller, N. M., Afghah, Z., & Geiger, J. D. (2019) · Journal of Parkinson’s Disease and Alzheimer’s Disease · doi:10.13188/2376-922x.1000028 · Cited by 10

Autoantibodies in the pathogenesis of idiopathic inflammatory myopathies: Does the endoplasmic reticulum stress response have a role?

Corona-Sánchez, E. G., Martínez-García, E. A., Lujano-Benítez, A. V., Pizano-Martínez, Ó., Guerra-Durán, I. A., Chavarría-Ávila, E., Aguilar-Vázquez, A., Martín-Márquez, B. T., Arellano-Arteaga, K. J., Armendáriz‐Borunda, J., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.940122 · Cited by 10

Mechanisms of Hypercapnia-Induced Endoplasmic Reticulum Dysfunction

Kryvenko, V., & Vadász, I. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.735580 · Cited by 9

The IRE1α pathway in glomerular diseases: The unfolded protein response and beyond

Navarro‐Betancourt, J. R., & Cybulsky, A. V. (2022) · Frontiers in Molecular Medicine · doi:10.3389/fmmed.2022.971247 · Cited by 9

Hhatl ameliorates endoplasmic reticulum stress through autophagy by associating with LC3

Shi, X., Yao, J., Huang, Y., Wang, Y., Jiang, X. J., Wang, Z., Zhang, M., Zhang, Y., & Liu, X. (2024) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2024.107335 · Cited by 9

Chemical Study of High-Mannose-Type Glycan-Related Proteins to Understand Their Functions at the Molecular Level

Kuribara, T., Hirose, M., Tajima, N., & Totani, K. (2024) · Trends in Glycoscience and Glycotechnology · doi:10.4052/tigg.2039.7e · Cited by 9

Precisely Designed Calcium-Based Nanomaterials: From Regulation of Cellular Ca 2+ Homeostasis to Cancer Therapy

Chen, L., Ye, Y., Meng, R.-Y., Xia, H., Chen, B., Wang, S., Kankala, R. K., & Chen, A. (2024) · ACS Materials Letters · doi:10.1021/acsmaterialslett.4c01432 · Cited by 9

Modulation of Orosomucoid-like Protein 3 Activity in the Management of Inflammatory Bowel Disease

Maličević, U., Rai, V., Škrbić, R., & Agrawal, D. K. (2024) · Journal of Biotechnology and Biomedicine · doi:10.26502/jbb.2642-91280167 · Cited by 9

DEPTOR attenuates asthma progression by suppressing endoplasmic reticulum stress through SOD1

Wang, H., Zhang, L., & Shang, Y. (2024) · Biology Direct · doi:10.1186/s13062-024-00557-z · Cited by 9

PAMK Ameliorates Non-Alcoholic Steatohepatitis and Associated Anxiety/Depression-like Behaviors Through Restoring Gut Microbiota and Metabolites in Mice

Yang, J., Ou, W., Lin, G., Wang, Y., Chen, D., Zeng, Z., Chen, Z., Lu, X., Wu, A., Lin, C., et al. (2024) · Nutrients · doi:10.3390/nu16223837 · Cited by 9

Research progress of effective components of traditional Chinese medicine in intervening apoptosis of renal tubular epithelial cells in diabetic kidney disease

Gong, Y. (2025) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2025.119874 · Cited by 9

Endoplasmic reticulum stress regulates swainsonine-induced the autophagy in renal tubular epithelial cells through UPR signaling pathway

Tang, L., Zhang, S., Zhai, Y., Wu, K., Wang, P., Liu, Y., Zhang, C., Yin, H., Tian, Y., Zhao, B., et al. (2025) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2025.179616 · Cited by 9

Adipocyte-driven unfolded protein response is a shared transcriptomic signature of metastatic prostate carcinoma cells

Herroon, M. K., Mecca, S., Haimbaugh, A. S., Garmo, L. C., Rajagurubandara, E. N., Todi, S. V., Baker, T. R., & Podgorski, I. (2021) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2021.119101 · Cited by 9

Fatty acids impact sarcomere integrity through myristoylation and ER homeostasis

Tang, H., Cui, M., & Han, M. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109539 · Cited by 9

The role of amyloid β in the pathological mechanism of GNE myopathy

Zhang, T., Shang, R., & Miao, J. (2022) · Neurological Sciences · doi:10.1007/s10072-022-06301-7 · Cited by 10

Novel Loss-of-Function Variant in HNF1a Induces β-Cell Dysfunction through Endoplasmic Reticulum Stress

Chen, Y.-L., Jia, J., Zhao, Q. C., Zhang, Y., Huang, B., Wang, L., Tian, J., Huang, C., Li, M., & Li, X. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232113022 · Cited by 9

Cudraflavone B induces human glioblastoma cells apoptosis via ER stress-induced autophagy

Pan, J., Zhao, R., Dong, C., Yang, J., Zhang, R., Sun, M., Ahmad, N., Zhou, Y., & Liu, Y. (2023) · BMC Neuroscience · doi:10.1186/s12868-023-00778-4 · Cited by 9

The Role of Non-coding RNAs in Methamphetamine-Induced Neurotoxicity

Xu, L., Li, L., Chen, Q., Huang, Y., Chen, X., & Qiao, D. (2023) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-023-01323-x · Cited by 9

Porcine Epidemic Diarrhea Virus and Its nsp14 Suppress ER Stress Induced GRP78

Zeng, W., Ren, J., Yang, G., Jiang, C., Dong, L., Sun, Q., Hu, Y., Li, W., & He, Q. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24054936 · Cited by 9

Physical Exercise Decreases Endoplasmic Reticulum Stress in Central and Peripheral Tissues of Rodents: A Systematic Review

Fernandes, M. S. D. S., Bădicu, G., Santos, G. C. J., Filgueira, T. O., Henrique, R. D. S., de Souza, R. F., Aidar, F. J., Souto, F. O., Brum, P. C., & Lagranha, C. J. (2023) · European Journal of Investigation in Health Psychology and Education · doi:10.3390/ejihpe13060082 · Cited by 9

Unraveling the roles of endoplasmic reticulum-associated degradation in metabolic disorders

Luo, H., Jiao, Q., Shen, C., Shao, C., Xie, J., Chen, Y., Feng, X. L., & Zhang, X. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1123769 · Cited by 9

BCL-3 Promotes Intracerebral Hemorrhage Progression by Increasing Blood–Brain Barrier Permeability, Inflammation, and Cell Apoptosis via Endoplasmic Reticulum Stress

Yin, H., Ran, Z., Luo, T., Jin, Z., & Ma, J. (2023) · Mediators of Inflammation · doi:10.1155/2023/1420367 · Cited by 9

Post-ovulatory aging affects mitochondria, spindle and protein metabolism in mouse oocytes

Zhang, C., Dong, X., Yuan, X., Song, J., Wang, J., Yin, X., Hou, Z., Cheng, L., Ma, S., Chen, Z., et al. (2023) · Reproduction · doi:10.1530/rep-23-0130 · Cited by 9

NRF2 signaling cascade in amyotrophic lateral sclerosis: bridging the gap between promise and reality

Tarot, P., Lasbleiz, C., & Liévens, J.-C. (2023) · Neural Regeneration Research · doi:10.4103/1673-5374.385283 · Cited by 9

Dynamic changes in endoplasmic reticulum morphology and its contact with the plasma membrane in motor neurons in response to nerve injury

Elgendy, M., Tamada, H., Taira, T., Iio, Y., Kawamura, A., Kunogi, A., Mizutani, Y., & Kiyama, H. (2024) · Cell and Tissue Research · doi:10.1007/s00441-024-03858-x · Cited by 9

IRE1α recognizes a structural motif in cholera toxin to activate an unfolded protein response

Simpson, M. S., Luca, H. E. D., Cauthorn, S., Luong, P., Udeshi, N. D., Svinkina, T., Schmieder, S. S., Carr, S. A., Grey, M. J., & Lencer, W. I. (2024) · The Journal of Cell Biology · doi:10.1083/jcb.202402062 · Cited by 9

The Interplay Between Endoplasmic Reticulum Stress and Oxidative Stress in Chondrocyte Catabolism

Kim, Y. J., Han, J., & Han, S. W. (2024) · Cartilage · doi:10.1177/19476035241245803 · Cited by 9

The ER Stress Induced in Human Neuroblastoma Cells Can Be Reverted by Lumacaftor, a CFTR Corrector

Pecoraro, M., Serra, A., Pascale, M. C., & Franceschelli, S. (2024) · Current Issues in Molecular Biology · doi:10.3390/cimb46090553 · Cited by 9

Elevation of liver endoplasmic reticulum stress in a modified choline-deficient l -amino acid-defined diet-fed non-alcoholic steatohepatitis mouse model

Muraki, Y., Makita, Y., Yamasaki, M., Amano, Y., & Matsuo, T. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.03.072 · Cited by 9

When nature’s robots go rogue: exploring protein homeostasis dysfunction and the implications for understanding human aging disease pathologies

Reisz, J. A., Barrett, A. S., Nemkov, T. G., Hansen, K. C., & D’Alessandro, A. (2018) · Expert Review of Proteomics · doi:10.1080/14789450.2018.1453362 · Cited by 11

Effect of liraglutide on endoplasmic reticulum stress in the renal tissue of type 2 diabetic rats

Zhao, X.-Y., Yu, T., Liu, S., Liu, Y.-J., Liu, J., & Qin, J. (2020) · World Journal of Diabetes · doi:10.4239/wjd.v11.i12.611 · Cited by 9

Endoplasmic reticulum stress and muscle dysfunction in congenital lipodystrophies

Campos, J. T. A. D. M., de Medeiros, J. L. D., de Melo, M. E. C., da Silva, M. A., de Sena, M. O., Sarmento, A. S. C., Agnez‐Lima, L. F., Fregonezi, G., & Lima, J. G. (2021) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2021.166120 · Cited by 9

The Epstein-Barr Virus Lytic Protein BMLF1 Induces Upregulation of GRP78 Expression through ATF6 Activation

Chen, L.-W., Wang, S.-S., Hung, C., Hung, Y.-H., Lin, C., & Chang, P. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22084024 · Cited by 9

Combination of Palmitic Acid and Methylseleninic Acid Induces Mitochondria-Dependent Apoptosis via Attenuation of the IRE1α Arm and Enhancement of CHOP in Hepatoma

Zhang, H., Zheng, Y., Han, D., Lu, J., Yin, S., Hu, H., & Zhao, C. (2021) · ACS Omega · doi:10.1021/acsomega.1c00959 · Cited by 9

Small molecule-mediated induction of endoplasmic reticulum stress in cancer cells

Pandey, S., Sharma, V. K., Biswas, A., Lahiri, M., & Basu, S. (2021) · RSC Medicinal Chemistry · doi:10.1039/d1md00095k · Cited by 9

The PERK/ATF4/CHOP signaling branch of the unfolded protein response mediates cisplatin-induced ototoxicity in hair cells

Qu, Y., Zong, S., Wang, Z., Du, P., Wen, Y., Li, H., Wu, N., & Xiao, H. (2022) · Drug and Chemical Toxicology · doi:10.1080/01480545.2022.2039181 · Cited by 9

A new adenine nucleotide transporter located in the ER is essential for maintaining the growth of Toxoplasma gondii

Li, S., Qian, J., Xu, M., Yang, J., He, Z., Zhao, T., Zhao, J., & Fang, R. (2022) · PLoS Pathogens · doi:10.1371/journal.ppat.1010665 · Cited by 9

The role and mechanism of unfolded protein response signaling pathway in methylmercury‐induced apoptosis of mouse spermatocytes germ cell‐2 cells

Zhang, X., Hao, H., Ma, K., Pang, H., Li, X., Tian, T., Hou, S., Ning, X., Wu, H., Hou, Q., et al. (2022) · Environmental Toxicology · doi:10.1002/tox.23684 · Cited by 9

Wolfram syndrome 1b mutation suppresses Mauthner-cell axon regeneration via ER stress signal pathway

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Iannotti, M. J., MacArthur, R., Jones, R. C., Tao, D., Singeç, I., Michael, S., & Inglese, J. (2019) · ACS Chemical Biology · doi:10.1021/acschembio.9b00001 · Cited by 9

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Huang, Y., Xu, Z., Yan, Y., Li, C., Yan, J., Wei, Y., Li, J., Zhang, L., Zhang, N., Bachert, C., et al. (2025) · Clinical & Experimental Allergy · doi:10.1111/cea.70107 · Cited by 8

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