Protein misfolding in the endoplasmic reticulum as a conduit to human disease

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Endoplasmic Reticulum Stress Links Obesity, Insulin Action, and Type 2 Diabetes

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THE MAMMALIAN UNFOLDED PROTEIN RESPONSE

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CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulumPreprint

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CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulumPreprint

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From endoplasmic-reticulum stress to the inflammatory response

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ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death

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XBP1 Links ER Stress to Intestinal Inflammation and Confers Genetic Risk for Human Inflammatory Bowel Disease

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1700029I15Rik orchestrates the biosynthesis of acrosomal membrane proteins required for sperm–egg interaction

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The protective role of Nrf2 on cognitive impairment in chronic intermittent hypoxia and sleep fragmentation mice

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The Dynamic Role of Endoplasmic Reticulum Stress in Chronic Liver Disease

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Endoplasmic Reticulum Selective Autophagy Alleviates Anthracycline-Induced Cardiotoxicity

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Tobacco as green bioreactor for therapeutic protein production: latest breakthroughs and optimization strategies

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IL ‐17A contributes to HSV 1 infection‐induced acute lung injury in a mouse model of pulmonary fibrosis

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Development and characterization of BODIPY-derived tracers for fluorescent labeling of the endoplasmic reticulum

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Neuroprotection Effect of Astragaloside IV from 2-DG-Induced Endoplasmic Reticulum Stress

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UFMylation of HRD1 regulates endoplasmic reticulum homeostasis

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Sestrin2 as a gatekeeper of cellular homeostasis: Physiological effects for the regulation of hypoxia‐related diseases

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Iron deficiency promotes aortic media degeneration by activating endoplasmic reticulum stress-mediated IRE1 signaling pathway

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Bip-Yorkie interaction determines oncogenic and tumor-suppressive roles of Ire1/Xbp1s activation

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An ER-targeted “reserve-release” fluorogen for topological quantification of reticulophagy

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Endoplasmic reticulum stress associates with the development of intervertebral disc degeneration

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Hepatotoxic mechanism of cantharidin: insights and strategies for therapeutic intervention

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Hepatotoxic effects of chronic exposure to environmentally relevant concentrations of Di-(2-ethylhexyl) phthalate (DEHP) on crucian carp: Insights from multi-omics analyses

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Hsp90, a team player in protein quality control and the stress response in bacteria

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Nanotechnology‐Mediated Immunomodulation Strategy for Inflammation Resolution

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The Role of Reductive Stress in the Pathogenesis of Endocrine-Related Metabolic Diseases and Cancer

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Mini-review on insulin resistance assessment: Advances in surrogate indices and clinical applications

Moriyama, K. (2025) · World Journal of Clinical Cases · doi:10.12998/wjcc.v13.i29.108380 · Cited by 26

Induction of blood-circulating bile acids supports recovery from myelosuppressive chemotherapy

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ERAP2 is a novel target involved in autophagy and activation of pancreatic stellate cells via UPR signaling pathway

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Targeting UPR branches, a potential strategy for enhancing efficacy of cancer chemotherapy

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Asthma Susceptibility Gene ORMDL3 Promotes Autophagy in Human Bronchial Epithelium

Guo, F., Hao, Y. T., Zhang, L., Croteau‐Chonka, D. C., Thibault, D. M., Kothari, P. H., Li, L., Levy, B. D., Zhou, X., & Raby, B. A. (2022) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2021-0305oc · Cited by 22

An Endoplasmic Reticulum (ER)‐Targeting DNA Nanodevice for Autophagy‐Dependent Degradation of Proteins in Membrane‐Bound Organelles

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Functional study and epigenetic targets analyses of SIRT1 in intramuscular preadipocytes via ChIP-seq and mRNA-seq

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Persistent Endoplasmic Reticulum Stress Stimulated by Peptide Assemblies for Sensitizing Cancer Chemotherapy

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(+)-Catechin ameliorates diabetic nephropathy injury by inhibiting endoplasmic reticulum stress-related NLRP3-mediated inflammation

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Oxidative photocatalysis on membranes triggers non-canonical pyroptosis

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General control nonderepressible 2 deletion predisposes to asparaginase-associated pancreatitis in mice

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Fine-tuning PERK signaling to control cell fate under stress

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The ER Stress Inducer l-Azetidine-2-Carboxylic Acid Elevates the Levels of Phospho-eIF2α and of LC3-II in a Ca2+-Dependent Manner

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Omentin protects H9c2 cells against docetaxel cardiotoxicity

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Dual Targeting of Endoplasmic Reticulum by Redox-Deubiquitination Regulation for Cancer Therapy

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Inositol Requiring Enzyme (IRE), a multiplayer in sensing endoplasmic reticulum stress

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YTHDF1 regulates endoplasmic reticulum stress, NF-κB, MAPK and PI3K-AKT signaling pathways in inflammatory osteoclastogenesis

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Development of a Photoactivatable Phosphine Probe for Induction of Intracellular Reductive Stress with Single‐Cell Precision

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The role of endoplasmic reticulum stress in type 2 diabetes mellitus mechanisms and impact on islet function

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The significance of calcium ions in cerebral ischemia-reperfusion injury: mechanisms and intervention strategies

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Furin-instructed molecular self-assembly actuates endoplasmic reticulum stress-mediated apoptosis for cancer therapy

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Leonurine attenuates cisplatin nephrotoxicity by suppressing the NLRP3 inflammasome, mitochondrial dysfunction, and endoplasmic reticulum stress

Zhang, Q., Sun, Q., Tong, Y., Bi, X., Chen, L., Lü, J., & Ding, W. Q. (2022) · International Urology and Nephrology · doi:10.1007/s11255-021-03093-1 · Cited by 21

Activation of endoplasmic reticulum stress in premature aging via the inner nuclear membrane protein SUN2

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The in vivo drug delivery pattern of the organelle-targeting small molecules

Fang, Z., & Chen, H. (2023) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2023.115020 · Cited by 21

Targeting the organelle for radiosensitization in cancer radiotherapy

Sun, X., Wu, L., Du, L., Xu, W., & Han, M. Y. (2024) · Asian Journal of Pharmaceutical Sciences · doi:10.1016/j.ajps.2024.100903 · Cited by 22

Mechanism of cigarette smoke in promoting small airway remodeling in mice via STAT 3 / PINK 1-Parkin / EMT

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Metabolic syndrome and dermatological diseases: association and treatment

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Stress Coping Strategies in the Heart: An Integrated View

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Defective endoplasmic reticulum export causes proinsulin misfolding in pancreatic β cells

Zhu, R., Li, X., Xu, J., Barrabi, C., Kekulandara, D. N., Woods, J., Chen, X., & Liu, M. R. (2019) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2019.110470 · Cited by 21

Hydroxycamptothecin Inhibits Peritendinous Adhesion via the Endoplasmic Reticulum Stress-Dependent Apoptosis

Yao, Z., Wang, W., Ning, J., Zhang, X., Zheng, W., Qian, Y., & Fan, C. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00967 · Cited by 21

In a search for efficient treatment for amyotrophic lateral sclerosis: Old drugs for new approaches

Kukharsky, M. S., Skvortsova, V. I., Бачурин, С. О., & Buchman, V. L. (2020) · Medicinal Research Reviews · doi:10.1002/med.21725 · Cited by 21

Impact of knockdown LincRNA-Cox2 on apoptosis of macrophage infected with Bacillus Calmette-Guérin

Xu, Y., Yu, J., Ma, C., Gong, Z., Wu, X., & Deng, G. (2020) · Molecular Immunology · doi:10.1016/j.molimm.2020.11.008 · Cited by 21

Berberine Ameliorates Oxygen-glucose Deprivation/Reperfusion-induced Apoptosis by Inhibiting Endoplasmic Reticulum Stress and Autophagy in PC12 Cells

Xie, P., Ren, Z., Lv, J., Hu, Y.-M., Guan, Z., & Yu, W. (2020) · Current Medical Science · doi:10.1007/s11596-020-2286-x · Cited by 21

Integrated signaling system under endoplasmic reticulum stress in eukaryotic microorganisms

Cao, T., Peng, B., Zhou, X., Cai, J., Tang, Y., Luo, J., Xie, H., Zhang, J., & Liu, S. (2021) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-021-11380-1 · Cited by 21

Lauric Acid Induces Apoptosis of Rice Sheath Blight Disease Caused by Rhizoctonia solani by Affecting Fungal Fatty Acid Metabolism and Destroying the Dynamic Equilibrium of Reactive Oxygen Species

Wang, J., Yang, C., Hu, X., Yao, X., Han, L. S., Wu, X., Li, R., Wen, T., & Ming, L. (2022) · Journal of Fungi · doi:10.3390/jof8020153 · Cited by 21

Neuroprotective Potential of Indole-Based Compounds: A Biochemical Study on Antioxidant Properties and Amyloid Disaggregation in Neuroblastoma Cells

Ciaglia, T., Miranda, M. R., Micco, S. D., Vietri, M., Smaldone, G., Musella, S., Sarno, V. D., Auriemma, G., Sardo, C., Moltedo, O., et al. (2024) · Antioxidants · doi:10.3390/antiox13121585 · Cited by 20

Cell Shock Absorption via Stress Relaxation Hydrogel Microspheres for Alleviating Endoplasmic Reticulum Stress in Chondrocytes

Zhao, D., Li, Y., Xiang, L., Saiding, Q., Lin, Z., Cai, Z., Wang, J., & Cui, W. (2025) · Research · doi:10.34133/research.0777 · Cited by 20

Chronic Heat Stress Caused Lipid Metabolism Disorder and Tissue Injury in the Liver of Huso dauricus via Oxidative-Stress-Mediated Ferroptosis

Zhang, Y., Li, Y., Wang, R., Wang, S., Sun, B., Cao, D., Sun, Z., Lv, W., Bo, M., & Zhang, Y. (2025) · Antioxidants · doi:10.3390/antiox14080926 · Cited by 20

The effect of various durations of cigarette smoke exposure on muscle fibre remodeling in rat diaphragms

Zhang, Y., Gao, J., & Luo, Y. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.109053 · Cited by 20

Melatonin ameliorated CUMS-induced depression-like behavior via restoring endoplasmic reticulum stress in rat hippocampus

Wang, S., Xu, X., Ju, X., Wang, S., Li, J., Yan, P., Yu, Z., & Song, M. (2020) · Neuroreport · doi:10.1097/wnr.0000000000001554 · Cited by 20

Aromatic monophenols from cinnamon bark act as proteasome inhibitors by upregulating ER stress, suppressing FoxM1 expression, and inducing apoptosis in prostate cancer cells

Gopalakrishnan, S., & Ismail, A. (2021) · Phytotherapy Research · doi:10.1002/ptr.7236 · Cited by 21

Levels of circulating GRP78 and CHOP in endoplasmic reticulum stress pathways in Chinese type 2 diabetic kidney disease patients

Ma, N., Xu, N., Yin, D., Zheng, P., Liu, W., Wang, G., Hui, Y., Han, G., Yang, C., & Cheng, X. (2021) · Medicine · doi:10.1097/md.0000000000026879 · Cited by 21

The Entropy Perspective on Human Illness and Aging

Wang, Z. (2021) · Engineering · doi:10.1016/j.eng.2021.08.014 · Cited by 20

Phosphorylation at Ser724 of the ER stress sensor IRE1α governs its activation state and limits ER stress–induced hepatosteatosis

Li, Y., Huang, S., Wang, J., Dai, J., Cai, J., Yan, S., Huang, Z., He, S., Wang, P., Liu, J., et al. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.101997 · Cited by 24

iASPP suppression mediates terminal UPR and improves BRAF-inhibitor sensitivity of colon cancers

Zheng, S., Wang, X., Liu, H., Zhao, D. H., Lin, Q., Jiang, Q., Li, L., & Hu, Y. (2022) · Cell Death and Differentiation · doi:10.1038/s41418-022-01086-w · Cited by 20

Mitochondria and Endoplasmic Reticulum Stress in Retinal Organoids from Patients with Vision Loss

Lee, E.-J., Diaz‐Aguilar, M. S., Min, H., Choi, J., Duran, D. A. V., Grandjean, J. M. D., Wiseman, R. L., Kroeger, H., & Lin, J. H. (2022) · American Journal Of Pathology · doi:10.1016/j.ajpath.2022.12.002 · Cited by 21

Neuroprotective role of plumbagin on eye damage induced by high-sucrose diet in adult fruit fly Drosophila melanogaster

Catalani, E., Quondam, S. D., Brunetti, K., Cherubini, A., Bongiorni, S., Taddei, A. R., Zecchini, S., Giovarelli, M., Palma, C. D., Perrotta, C., et al. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115298 · Cited by 20

Surface-Functionalized Halo-Tag Gold Nanoprobes for Live-Cell Long-Term Super-Resolution Imaging of Endoplasmic Reticulum Dynamics

Xu, P., Zhong, S., Wei, Y., Duan, X., Zhang, M., Shen, W., Ma, Y., & Zhang, Y. (2024) · ACS Nano · doi:10.1021/acsnano.4c06138 · Cited by 20

Urinary Angiogenin Reflects the Magnitude of Kidney Injury at the Infrahistologic Level

Tavernier, Q., Mami, I., Rabant, M., Karras, A., Laurent‐Puig, P., Chevet, É., Thervet, É., Anglicheau, D., & Pallet, N. (2016) · Journal of the American Society of Nephrology · doi:10.1681/asn.2016020218 · Cited by 21

Selective Manipulation of Discrete Mannosidase Activities in the Endoplasmic Reticulum by Using Reciprocally Selective Inhibitors

Kuribara, T., Hirano, M., Speciale, G., Williams, S. J., Ito, Y., & Totani, K. (2017) · ChemBioChem · doi:10.1002/cbic.201700081 · Cited by 20

Endoplasmic Reticulum: Target for Next‐Generation Cancer Therapy

Banerjee, S., & Zhang, W. (2018) · ChemBioChem · doi:10.1002/cbic.201800461 · Cited by 20

Expression of genes encoding IGF1, IGF2, and IGFBPs in blood of obese adolescents with insulin resistance

Minchenko, D. O., Tsymbal, D. O., Davydov, V. V., & Minchenko, О. H. (2019) · Endocrine Regulations · doi:10.2478/enr-2019-0005 · Cited by 20

Increased ER Stress After Experimental Ischemic Optic Neuropathy and Improved RGC and Oligodendrocyte Survival After Treatment With Chemical Chaperon

Kumar, V., Mesentier-Louro, L. A., Oh, A. J., Heng, K., Shariati, A., Huang, H., Hu, Y., & Liao, Y. J. (2019) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.18-24890 · Cited by 20

Penehyclidine hydrochloride defends against LPS-induced ALI in rats by mitigating endoplasmic reticulum stress and promoting the Hes1/Notch1 pathway

Weng, J., Chen, M., Lin, Q., Chen, J., Wang, S., & Fang, D. (2019) · Gene · doi:10.1016/j.gene.2019.144095 · Cited by 20

Pathogenic Effects of Impaired Retrieval between the Endoplasmic Reticulum and Golgi Complex

Kokubun, H., Jin, H., & Aoe, T. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20225614 · Cited by 20

Activation of the IRE1α Arm, but not the PERK Arm, of the Unfolded Protein Response Contributes to Fumonisin B1-Induced Hepatotoxicity

Liu, X., Zhang, E., Yin, S., Zhao, C., Fan, L., & Hu, H. (2020) · Toxins · doi:10.3390/toxins12010055 · Cited by 20

Chlamydia pneumoniae infection–induced endoplasmic reticulum stress causes fatty acid–binding protein 4 secretion in murine adipocytes

Walenna, N. F., Kurihara, Y., Chou, B., Ishii, K., Soejima, T., & Hiromatsu, K. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.010683 · Cited by 20

Control of stress-induced apoptosis by freezing tolerance-associated wheat proteins during cryopreservation of rat hepatocytes

Chow‐Shi‐Yée, M., Grondin, M., Ouellet, F., & Averill‐Bates, D. A. (2020) · Cell Stress and Chaperones · doi:10.1007/s12192-020-01115-y · Cited by 20

Role of IRE1α in podocyte proteostasis and mitochondrial health

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4-Methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene, a Major Active Metabolite of Bisphenol A, Triggers Pancreatic β-Cell Death via a JNK/AMPKα Activation-Regulated Endoplasmic Reticulum Stress-Mediated Apoptotic Pathway

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