Protein misfolding in the endoplasmic reticulum as a conduit to human disease

Control of inositol 1,4,5-trisphosphate-induced Ca2+ release by cytosolic Ca2+

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The unfolded protein response: controlling cell fate decisions under ER stress and beyond

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Endoplasmic Reticulum Stress Links Obesity, Insulin Action, and Type 2 Diabetes

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THE MAMMALIAN UNFOLDED PROTEIN RESPONSE

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CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulumPreprint

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CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulumPreprint

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From endoplasmic-reticulum stress to the inflammatory response

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Reactive Oxygen Species Promote TNFα-Induced Death and Sustained JNK Activation by Inhibiting MAP Kinase Phosphatases

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ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death

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XBP1 Links ER Stress to Intestinal Inflammation and Confers Genetic Risk for Human Inflammatory Bowel Disease

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Methamphetamine induces GSDME-dependent cell death in hippocampal neuronal cells through the endoplasmic reticulum stress pathway

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Derlin-3 Is Required for Changes in ERAD Complex Formation under ER Stress

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NRF2‐mediated SIRT3 induction protects hepatocytes from ER stress‐induced liver injury

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Urinary ERdj3 and mesencephalic astrocyte-derived neutrophic factor identify endoplasmic reticulum stress in glomerular disease

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Melatonin attenuates diabetic cardiomyopathy by increasing autophagy of cardiomyocytes via regulation of VEGF-B/GRP78/PERK signaling pathway

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Calcium Deregulation in Neurodegeneration and Neuroinflammation in Parkinson’s Disease: Role of Calcium-Storing Organelles and Sodium–Calcium Exchanger

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Human protein secretory pathway genes are expressed in a tissue-specific pattern to match processing demands of the secretome

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Protein biosynthesis, a target of sorafenib, interferes with the unfolded protein response (UPR) and ferroptosis in hepatocellular carcinoma cells

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Cellular Stress Responses and Gut Microbiota in Inflammatory Bowel Disease

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Levels of glial cell line‐derived neurotrophic factor are decreased, but fibroblast growth factor 2 and cerebral dopamine neurotrophic factor are increased in the hippocampus in Parkinson’s disease

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Connecting cancer relapse with senescence

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Endoplasmic reticulum stress, a new wrestler, in the pathogenesis of idiopathic pulmonary fibrosis.

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Widespread occurrence of microRNA-mediated target cleavage on membrane-bound polysomes

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Targeting unfolded protein response: a new horizon for disease control

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Effects of Polyphenols in Aging and Neurodegeneration Associated with Oxidative Stress

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Ectopic clotting factor VIII expression and misfolding in hepatocytes as a cause for hepatocellular carcinoma

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Increasing Stress to Induce Apoptosis in Pancreatic Cancer via the Unfolded Protein Response (UPR)

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Curcumin and analogues against head and neck cancer: From drug delivery to molecular mechanisms

Zhao, C., Zhou, X., Cao, Z., Ye, L., Cao, Y., & Pan, J. (2023) · Phytomedicine · doi:10.1016/j.phymed.2023.154986 · Cited by 37

Unfolded Protein Response of the Endoplasmic Reticulum in Tumor Progression and Immunogenicity

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The PPP1R15 Family of eIF2-alpha Phosphatase Targeting Subunits (GADD34 and CReP)

Hicks, D., Giresh, K., Wrischnik, L. A., & Weiser, D. C. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242417321 · Cited by 41

Modulation of Molecular Chaperones in Huntington’s Disease and Other Polyglutamine Disorders

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Protective Effects of Olive Leaf Extract on Acrolein-Exacerbated Myocardial Infarction via an Endoplasmic Reticulum Stress Pathway

Xu, Y., Wu, L., Chen, A., Xu, C., & Feng, Q. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19020493 · Cited by 36

Increased sensitivity to apoptosis upon endoplasmic reticulum stress-induced activation of the unfolded protein response in chemotherapy-resistant malignant pleural mesothelioma

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Three branches to rule them all? UPR signalling in response to chemically versus misfolded proteins‐induced ER stress

Bergmann, T. J., & Molinari, M. (2018) · Biology of the Cell · doi:10.1111/boc.201800029 · Cited by 36

Impact of the Reticular Stress and Unfolded Protein Response on the inflammatory response in endometrial stromal cells

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4-Sodium phenyl butyric acid has both efficacy and counter-indicative effects in the treatment of Col4a1 disease

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KSHV activates unfolded protein response sensors but suppresses downstream transcriptional responses to support lytic replication

Johnston, B. P., Pringle, E. S., & McCormick, C. (2019) · PLoS Pathogens · doi:10.1371/journal.ppat.1008185 · Cited by 36

InP/ZnS Quantum Dots Cause Inflammatory Response in Macrophages Through Endoplasmic Reticulum Stress and Oxidative stress

Chen, S., Chen, Y., Chen, Y., & Yao, Z. (2019) · International Journal of Nanomedicine · doi:10.2147/ijn.s218748 · Cited by 36

The Impact of the ER Unfolded Protein Response on Cancer Initiation and Progression: Therapeutic Implications

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ADAR1-Dependent RNA Editing Promotes MET and iPSC Reprogramming by Alleviating ER Stress

Guallar, D., Fuentes-Iglesias, A., Souto, Y., Ameneiro, C., Freire-Agulleiro, Ó., Pardavila, J. Á., Escudero, A., Garcia‐Outeiral, V., Moreira, T., Sáenz, C., et al. (2020) · Cell stem cell · doi:10.1016/j.stem.2020.04.016 · Cited by 36

Unfolded protein response in cardiovascular disease

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Research on endoplasmic reticulum–targeting fluorescent probes and endoplasmic reticulum stress–mediated nanoanticancer strategies: A review

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Bushen Jieyu Tiaochong Formula reduces apoptosis of granulosa cells via the PERK-ATF4-CHOP signaling pathway in a rat model of polycystic ovary syndrome with chronic stress

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Endoplasmic Reticulum Stress and Pathogenesis of Vascular Calcification

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Cold exposure‐induced endoplasmic reticulum stress regulates autophagy through the SIRT2/FoxO1 signaling pathway

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Light activation of iridium(III) complexes driving ROS production and DNA damage enhances anticancer activity in A549 cells

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Most cancers carry a substantial deleterious load due to Hill-Robertson interference

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Organellar Calcium Handling in the Cellular Reticular NetworkPreprint

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Axon injury induced endoplasmic reticulum stress and neurodegeneration

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Spliced XBP1 Levels Determine Sensitivity of Multiple Myeloma Cells to Proteasome Inhibitor Bortezomib Independent of the Unfolded Protein Response Mediator GRP78

Borjan, B., Kern, J., Steiner, N., Gunsilius, E., Wolf, D. G. F., & Untergasser, G. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2019.01530 · Cited by 35

Translational Control of Secretory Proteins in Health and Disease

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NF-κB Activation Accounts for the Cytoprotective Effects of PERK Activation on Oligodendrocytes during EAE

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Interaction of HSPA5 (Grp78, BIP) with negatively charged phospholipid membranes via oligomerization involving the N-terminal end domain

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Matrix Metalloproteinase-11 Promotes Early Mouse Mammary Gland Tumor Growth through Metabolic Reprogramming and Increased IGF1/AKT/FoxO1 Signaling Pathway, Enhanced ER Stress and Alteration in Mitochondrial UPR

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Multi-omics reveals the anticancer mechanism of asparagus saponin-asparanin A on endometrial cancer Ishikawa cells

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Paeonol for the Treatment of Atherosclerotic Cardiovascular Disease: A Pharmacological and Mechanistic Overview

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The Mitochondrial‐Associated Endoplasmic Reticulum Membrane and Its Role in Diabetic Nephropathy

Ni, L., & Cheng, Y. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/8054817 · Cited by 35

Protein Aggregation in the ER: Calm behind the Storm

Li, H., & Sun, S. (2021) · Cells · doi:10.3390/cells10123337 · Cited by 36

Selective Histone Deacetylase 6 Inhibitor 23BB Alleviated Rhabdomyolysis-Induced Acute Kidney Injury by Regulating Endoplasmic Reticulum Stress and Apoptosis

Feng, Y., Huang, R., Guo, F., Liang, Y., Xiang, J., Song, L., Shi, M., Li, L., Liu, J., Feng, Y., et al. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00274 · Cited by 35

Protein quality control and aggregation in the endoplasmic reticulum: From basic to bedside

Chen, G., Wei, T., Ju, F., & Li, H. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1156152 · Cited by 36

Lipid disequilibrium disrupts ER proteostasis by impairing ERAD substrate glycan trimming and dislocation

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Mechanisms of cell death induction by food-borne mycotoxins

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A Non-structural 1 Protein G53D Substitution Attenuates a Clinically Tested Live Dengue Vaccine

Choy, M. M. J., Ng, D. H. L., Siriphanitchakorn, T., Ng, W. C., Sundstrom, K. B., Tan, H. C., Zhang, S. L.-X., Chan, K. W. K., Manuel, M., Kini, R. M., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.107617 · Cited by 34

Pectin lyase enhances cotton resistance to Verticillium wilt by inducing cell apoptosis of Verticillium dahliae

Zhang, J., Yu, X., Zhang, C., Zhang, Q., Sun, Y., Zhu, H., & Tang, C. (2020) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2020.124029 · Cited by 34

Folate enzyme MTHFD2 links one-carbon metabolism to unfolded protein response in glioblastoma

Zhu, Z., Kiang, K. M. Y., Li, N., Liu, J., Zhang, P., Jin, L., He, X., Zhang, S., & Leung, G. (2022) · Cancer Letters · doi:10.1016/j.canlet.2022.215903 · Cited by 34

Formaldehyde Is a Potent Proteotoxic Stressor Causing Rapid Heat Shock Transcription Factor 1 Activation and Lys48-Linked Polyubiquitination of Proteins

Ortega-Atienza, S., Rubiś, B., McCarthy, C., & Zhitkovich, A. (2016) · American Journal Of Pathology · doi:10.1016/j.ajpath.2016.06.022 · Cited by 34

Therapeutics for APOL1 nephropathies: putting out the fire in the podocyte

Heymann, J. A. W., Winkler, C. A., Hoek, M., Suszták, K., & Kopp, J. B. (2016) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfw402 · Cited by 34

Retinal Damage in Amyotrophic Lateral Sclerosis: Underlying Mechanisms

Soldatov, V. O., Kukharsky, M. S., Белых, А. Е., Sobolev, A., & Deykin, A. V. (2021) · Eye and Brain · doi:10.2147/eb.s299423 · Cited by 35

Molecular mechanisms of Na,K-ATPase dysregulation driving alveolar epithelial barrier failure in severe COVID-19

Kryvenko, V., & Vadász, I. (2021) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00056.2021 · Cited by 34

Liquid-liquid phase separation in Alzheimer’s disease

Fu, Q., Zhang, B., Chen, X., & Chu, L. (2024) · Journal of Molecular Medicine · doi:10.1007/s00109-023-02407-3 · Cited by 33

Proteomics reveals changes in hepatic proteins during chicken embryonic development: an alternative model to study human obesity

Peng, M., Li, S., He, Q., Zhao, J., Li, L., & Ma, H. (2018) · BMC Genomics · doi:10.1186/s12864-017-4427-6 · Cited by 33

PARK7 modulates autophagic proteolysis through binding to the N-terminally arginylated form of the molecular chaperone HSPA5

Lee, D., Kim, D.-H., Kim, S. T., Jeong, S., Kim, J. L., Shim, S. M., Heo, A. J., Song, X., Guo, Z. S., Bartlett, D. L., et al. (2018) · Autophagy · doi:10.1080/15548627.2018.1491212 · Cited by 33

Binding to an Unusual Inactive Kinase Conformation by Highly Selective Inhibitors of Inositol-Requiring Enzyme 1α Kinase-Endoribonuclease

Colombano, G., Caldwell, J., Matthews, T. P., Bhatia, C., Joshi, A., McHardy, T., Mok, N. Y., Newbatt, Y. M., Pickard, L., Strover, J., et al. (2019) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.8b01721 · Cited by 33

The Integrated UPR and ERAD in Oligodendrocytes Maintain Myelin Thickness in Adults by Regulating Myelin Protein Translation

Wu, S., Stone, S., Nave, K., & Lin, W. (2020) · Journal of Neuroscience · doi:10.1523/jneurosci.0604-20.2020 · Cited by 33

Anthocyanins from Hibiscus syriacus L. Inhibit NLRP3 Inflammasome in BV2 Microglia Cells by Alleviating NF‐κB‐ and ER Stress‐Induced Ca2+ Accumulation and Mitochondrial ROS Production

Molagoda, I. M. N., Lee, K. T., Choi, Y. H., Jayasingha, J. A. C. C., & Kim, G. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/1246491 · Cited by 33

How Cells Deal with the Fluctuating Environment: Autophagy Regulation under Stress in Yeast and Mammalian Systems

Lei, Y., Huang, Y. J., Wen, X., Yin, Z., Zhang, Z., & Klionsky, D. J. (2022) · Antioxidants · doi:10.3390/antiox11020304 · Cited by 36

Maternal hypothyroidism causes oxidative stress and endoplasmic reticulum stress in the maternal-fetal interface of rats

Cordeiro, J. M. D. A., Santos, L. C., de Oliveira, L. S., Santos, B. R., Santos, E. O., Barbosa, E. M., de Macêdo, I. O., de Freitas, G. J. C., Santos, D. A., de Lavor, M. S. L., et al. (2022) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2022.08.033 · Cited by 33

Stress responses to warming in Japanese flounder (Paralichthys olivaceus) from different environmental scenarios

Han, P., Qiao, Y., He, J., & Wang, X. (2023) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2023.165341 · Cited by 33

Progressing neurobiological strategies against proteostasis failure: Challenges in neurodegeneration

Amanullah, A., Upadhyay, A., Joshi, V., Mishra, R., Jana, N. R., & Mishra, A. (2017) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2017.08.005 · Cited by 34

4-Phenylbutyrate suppresses the unfolded protein response without restoring protein folding in Saccharomyces cerevisiae

Mai, C. T., Le, Q. G., Ishiwata‐Kimata, Y., Takagi, H., Kohno, K., & Kimata, Y. (2018) · FEMS Yeast Research · doi:10.1093/femsyr/foy016 · Cited by 33

SIRT6 deficiency in endothelial cells exacerbates oxidative stress by enhancing HIF1α accumulation and H3K9 acetylation at the Ero1α promoter

Guo, Z., Yu, X., Zhao, S., Zhong, X., Huang, D., Feng, R., Li, P., Fang, Z., Hu, Y., Zhang, Z., et al. (2023) · Clinical and Translational Medicine · doi:10.1002/ctm2.1377 · Cited by 35

PM2.5 triggers autophagic degradation of Caveolin-1 via endoplasmic reticulum stress (ERS) to enhance the TGF-β1/Smad3 axis promoting pulmonary fibrosis

Liu, H., Lai, W., Nie, H., Shi, Y., Zhu, L., Yang, L., Tian, L., Li, K., Bian, L., Xi, Z., et al. (2023) · Environment International · doi:10.1016/j.envint.2023.108290 · Cited by 33

Prodigiosin: unveiling the crimson wonder – a comprehensive journey from diverse bioactivity to synthesis and yield enhancement

Lu, Y., Liu, D., Jiang, R., Li, Z., & Gao, X. (2024) · Frontiers in Microbiology · doi:10.3389/fmicb.2024.1412776 · Cited by 32

Bushen-Yizhi formula ameliorates cognitive dysfunction through SIRT1/ER stress pathway in SAMP8 mice

Zhang, S., Xu, T., Li, L., Xu, Y., Qu, Z.-L., Wang, X.-C., Huang, S., Luo, Y., Luo, N., Lü, P., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.17638 · Cited by 32

Elucidation of stable intermediates in urea-induced unfolding pathway of human carbonic anhydrase IX

Prakash, A., Dixit, G., Meena, N. K., Singh, R., Vishwakarma, P., Mishra, S., & Lynn, A. M. (2017) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2017.1355847 · Cited by 32

Synthesis of indocyanine green functionalized comblike poly(aspartic acid) derivatives for enhanced cancer cell ablation by targeting the endoplasmic reticulum

Wan, J., Sun, L., Wu, P., Wang, F., Guo, J., Cheng, J., & Wang, C. (2018) · Polymer Chemistry · doi:10.1039/c7py01994g · Cited by 32

Both thapsigargin- and tunicamycin-induced endoplasmic reticulum stress increases expression of Hrd1 in IRE1-dependent fashion

Dibdiaková, K., Saksonova, S., Pilchová, I., Klacanova, K., Tatarková, Z., & Račay, P. (2018) · Neurological Research · doi:10.1080/01616412.2018.1547856 · Cited by 32

Current approach and novel perspectives in nasopharyngeal carcinoma: the role of targeting proteasome dysregulation as a molecular landmark in nasopharyngeal cancer

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Effects of the maternal gut microbiome and gut-placental axis on melatonin efficacy in alleviating cadmium-induced fetal growth restriction

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Therapeutic potential of endoplasmic reticulum stress inhibitors in the treatment of diabetic peripheral neuropathy

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Protein Folding and the Challenges of Maintaining Endoplasmic Reticulum Proteostasis in Idiopathic Pulmonary Fibrosis

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Mechanisms of protection of retinal pigment epithelial cells from oxidant injury by humanin and other mitochondrial-derived peptides: Implications for age-related macular degeneration

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Modeling complex age-related eye disease

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The role of taurine through endoplasmic reticulum in physiology and pathology

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Deoxycholic acid supplementation impairs glucose homeostasis in mice

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Dietary Methionine Restriction Upregulates Endogenous H 2 S via miR‐328‐3p: A Potential Mechanism to Improve Liver Protein Metabolism Efficiency in a Mouse Model of High‐fat‐diet‐induced Obesity

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MiR-17-5p-mediated endoplasmic reticulum stress promotes acute myocardial ischemia injury through targeting Tsg101

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Myocilin-associated Glaucoma: A Historical Perspective and Recent Research Progress.

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Radioresistance of Human Cancers: Clinical Implications of Genetic Expression Signatures

de Mey, S., Dufait, I., & Ridder, M. D. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.761901 · Cited by 33

The respiratory cytotoxicity of typical organophosphorus flame retardants on five different respiratory tract cells: Which are the most sensitive one?

Chen, J., Li, G., Yu, H., Liu, H., & An, T. (2022) · Environmental Pollution · doi:10.1016/j.envpol.2022.119564 · Cited by 31

A heat shock protein-inhibiting molecular photothermal agent for mild-temperature photothermal therapy

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Pharmacological Regulation of Endoplasmic Reticulum Structure and Calcium Dynamics: Importance for Neurodegenerative Diseases

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Role of the ER-induced UPR pathway, apoptosis, and autophagy in colorectal cancer

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Integrated Stress Responses to Bacterial Pathogenesis Patterns

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Emerging Roles for Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) in Pancreatic Beta Cells and Diabetes

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Lithocholic acid activates mTOR signaling inducing endoplasmic reticulum stress in placenta during intrahepatic cholestasis of pregnancy

Sheng, C., Xiaojun, L., Hai-zhen, W., Fu, L., Shaozhen, L., Su, Z., Weiliang, H., Chunhong, J., Wang, Y., Wu, F., et al. (2018) · Life Sciences · doi:10.1016/j.lfs.2018.12.050 · Cited by 31

Potential benefit of manipulating protein quality control systems in neurodegenerative diseases

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Potential targets for the treatment of MI: GRP75-mediated Ca2+ transfer in MAM

Zhang, C., Liu, B., Sheng, J., Wang, J., Zhu, W., Xie, C., Zhou, X., Zhang, Y., Meng, Q., & Li, Y. (2024) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2024.176530 · Cited by 30

What Is Next in This “Age” of Heme-Driven Pathology and Protection by Hemopexin? An Update and Links with Iron

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Mapping Keratoconus Molecular Substrates by Multiplexed High-Resolution Proteomics of Unpooled Corneas

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Endoplasmic Reticulum Stress in Disease

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Endoplasmic Reticulum Stress in Disease Pathogenesis

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Cellular Mechanisms of Endoplasmic Reticulum Stress Signaling in Health and Disease

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Protein Folding in the Endoplasmic Reticulum and the Unfolded Protein Response

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