Cited by 1,630Endoplasmic Reticulum Stress and DiseaseHeat shock proteins researchCellular transport and secretion

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Protein misfolding in the endoplasmic reticulum as a conduit to human disease

Wang, Miao, Kaufman, Randal J.·2016·Nature

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Abstract

In eukaryotic cells, the endoplasmic reticulum is essential for the folding and trafficking of proteins that enter the secretory pathway. Environmental insults or increased protein synthesis often lead to protein misfolding in the organelle, the accumulation of misfolded or unfolded proteins - known as endoplasmic reticulum stress - and the activation of the adaptive unfolded protein response to restore homeostasis. If protein misfolding is not resolved, cells die. Endoplasmic reticulum stress and activation of the unfolded protein response help to determine cell fate and function. Furthermore, endoplasmic reticulum stress contributes to the aetiology of many human diseases.

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Authors: Wang, M., & Kaufman, R. J.
Affiliations: Sanford Burnham Prebys Medical Discovery Institute (US)
Corresponding author: Kaufman, Randal J.
ORCID: Wang, Miao
Kaufman, Randal J.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2016-01
Volume: 529
Issue: 7586
Pages: 326-335
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature17041
OpenAlex: W2263498456
Cited by: 1,630
References: 126
Citations by year: 2026: 127 · 2025: 166 · 2024: 177 · 2023: 180 · 2022: 200 · 2021: 179 · 2020: 185 · 2019: 137 · 2018: 120 · 2017: 113 · 2016: 44
FWCI: 14.97
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Funders: National Institutes of Health
National Cancer Institute (P01CA128814, CA-128814)
National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK103183)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Endoplasmic Reticulum Stress and Disease
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heat shock proteins research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
Keywords: protein misfolding, endoplasmic reticulum stress, unfolded protein response, secretory pathway, protein folding, protein trafficking, cell fate, human disease, ER-associated degradation
MeSH terms: Animals, Disease, Endoplasmic Reticulum, Humans, Proteins, Protein Folding, Unfolded Protein Response, Molecular Targeted Therapy, Endoplasmic Reticulum Stress

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Protein misfolding in the endoplasmic reticulum as a conduit to human disease

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